quinisocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	3153	86-80-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

quinisocaine hydrochloride
dimethisoquin
quinisocain
quinisocaine
quinoleine
dimethisoquin hydrochloride
dimethisoquin HCl

Molecular weight: 272.39
Formula: C17H24N2O
CLOGP: 4.82
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 25.36
ALOGS: -3.62
ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D04AB05	DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use
MeSH PA	D000777	Anesthetics
MeSH PA	D000779	Anesthetics, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.0	Basic
pKa2	5.2	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.47		CHEMBL

External reference:

ID	Source
D06661	KEGG_DRUG
CHEBI:93295	CHEBI
CHEMBL127643	ChEMBL_ID
CHEMBL1533364	ChEMBL_ID
C009146	MESH_SUPPLEMENTAL_RECORD_UI
2773-92-4	SECONDARY_CAS_RN
DB13683	DRUGBANK_ID
001374	NDDF
004576	NDDF
26379008	SNOMEDCT_US
734652004	SNOMEDCT_US
C0058202	UMLSCUI
367	INN_ID
6857	PUBCHEM_CID
772EN3BH6I	UNII

Pharmaceutical products:

None