dimethicone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3152 9006-65-9

Description:

MoleculeDescription

Synonyms:

  • simethicone
  • dimethicone
  • Silicone Fluid 350
  • polydimethylsiloxane
  • dimeticone
  • dimethicone 410
A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.
  • Molecular weight:
  • Formula: C6H18Si2(C2H6O2Si)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 26, 1997 FDA MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2101.99 9.33 2266 169494 143407 63173855
Toxicity to various agents 911.40 9.33 2042 169718 245208 63072054
Drug abuse 677.81 9.33 906 170854 71612 63245650
Cardio-respiratory arrest 370.11 9.33 617 171143 59342 63257920
Milk-alkali syndrome 324.51 9.33 111 171649 717 63316545
Liver injury 274.56 9.33 545 171215 59975 63257287
Alcohol interaction 262.67 9.33 129 171631 2280 63314982
Intentional overdose 242.14 9.33 585 171175 73567 63243695
Drug ineffective 228.01 9.33 1777 169983 1042988 62274274
Macular degeneration 192.40 9.33 281 171479 24095 63293167
Suspected suicide 168.87 9.33 141 171619 6427 63310835
Overdose 161.41 9.33 678 171082 114400 63202862
Suicide attempt 154.17 9.33 437 171323 60481 63256781
Hypocalcaemia 135.92 9.33 279 171481 31434 63285828
Hypomania 121.16 9.33 115 171645 6215 63311047
Coma 120.59 9.33 416 171344 63948 63253314
Alcohol poisoning 119.92 9.33 71 171689 1848 63315414
Pneumonia aspiration 111.09 9.33 271 171489 34269 63282993
Jaundice cholestatic 108.84 9.33 116 171644 7208 63310054
Schizophrenia 104.81 9.33 132 171628 9820 63307442
Hepatotoxicity 101.91 9.33 274 171486 36767 63280495
Gastrooesophageal reflux disease 98.43 9.33 515 171245 95124 63222138
Recalled product 95.85 9.33 55 171705 1348 63315914
Alcohol abuse 95.42 9.33 64 171696 2082 63315180
Exposure to toxic agent 92.93 9.33 94 171666 5493 63311769
Product dose omission issue 92.73 9.33 324 171436 233989 63083273
Alcohol use 92.44 9.33 62 171698 2017 63315245
Psoriatic arthropathy 85.51 9.33 480 171280 91040 63226222
Respiratory arrest 84.35 9.33 236 171524 32409 63284853
Facet joint syndrome 74.96 9.33 125 171635 12013 63305249
Lip dry 72.14 9.33 141 171619 15329 63301933
Peripheral venous disease 72.10 9.33 141 171619 15336 63301926
Device expulsion 71.96 9.33 6 171754 34916 63282346
Rash 67.00 9.33 1091 170669 559780 62757482
Nasal obstruction 66.08 9.33 47 171713 1684 63315578
Diarrhoea 66.02 9.33 2459 169301 712907 62604355
Abdominal pain 64.92 9.33 1135 170625 292321 63024941
Hypercalcaemia 63.82 9.33 195 171565 28127 63289135
Asphyxia 63.53 9.33 81 171679 6100 63311162
Vaginal flatulence 61.46 9.33 59 171701 3234 63314028
Somnolence 60.41 9.33 744 171016 177941 63139321
Nephrocalcinosis 59.92 9.33 37 171723 1041 63316221
Gastrointestinal toxicity 59.29 9.33 88 171672 7653 63309609
Neurologic neglect syndrome 58.99 9.33 53 171707 2668 63314594
Injection site erythema 57.32 9.33 85 171675 83089 63234173
Proctitis 55.45 9.33 71 171689 5370 63311892
Methaemoglobinaemia 54.47 9.33 48 171712 2355 63314907
Drug hypersensitivity 54.16 9.33 558 171202 310129 63007133
Calcium ionised decreased 54.08 9.33 23 171737 286 63316976
Carotid artery thrombosis 53.93 9.33 51 171709 2743 63314519
Injection site pain 53.67 9.33 176 171584 129624 63187638
Deep vein thrombosis postoperative 53.47 9.33 104 171656 11265 63305997
Wheezing 50.43 9.33 436 171324 95159 63222103
Throat clearing 50.25 9.33 46 171714 2373 63314889
Injection site reaction 49.59 9.33 51 171709 58473 63258789
Lupus vulgaris 48.60 9.33 70 171690 5924 63311338
Segmental diverticular colitis 48.06 9.33 18 171742 156 63317106
Pedal pulse abnormal 47.27 9.33 18 171742 164 63317098
Pruritus 46.13 9.33 694 171066 360759 62956503
Blood calcium decreased 45.27 9.33 166 171594 26285 63290977
Headache 44.12 9.33 1341 170419 631900 62685362
Nicotine dependence 43.43 9.33 26 171734 691 63316571
Injection site swelling 43.16 9.33 39 171721 47533 63269729
Adjustment disorder 43.15 9.33 48 171712 3130 63314132
Intentional product misuse 42.78 9.33 297 171463 60620 63256642
Pulmonary toxicity 42.66 9.33 85 171675 9370 63307892
Pain 42.16 9.33 1609 170151 739019 62578243
Postmortem blood drug level abnormal 41.52 9.33 20 171740 338 63316924
Full blood count abnormal 40.68 9.33 182 171578 31535 63285727
Hypophosphataemic osteomalacia 40.58 9.33 17 171743 203 63317059
Alcoholism 40.58 9.33 36 171724 1782 63315480
Asthma-chronic obstructive pulmonary disease overlap syndrome 40.51 9.33 38 171722 2023 63315239
Psychotic disorder 40.39 9.33 157 171603 25555 63291707
Dehydration 39.91 9.33 675 171085 172679 63144583
Frequent bowel movements 39.84 9.33 145 171615 22877 63294385
Injection site pruritus 39.73 9.33 38 171722 45078 63272184
Rheumatic fever 39.51 9.33 225 171535 42886 63274376
Myelosuppression 39.48 9.33 8 171752 23695 63293567
No adverse event 38.70 9.33 33 171727 41372 63275890
Off label use 38.64 9.33 1464 170296 672998 62644264
Autoimmune disorder 38.45 9.33 118 171642 17059 63300203
Therapeutic product effect decreased 38.30 9.33 336 171424 192851 63124411
Herpes zoster 38.25 9.33 106 171654 82356 63234906
Constipation 38.17 9.33 836 170924 224107 63093155
Blood alcohol increased 37.83 9.33 23 171737 629 63316633
Tetany 37.62 9.33 36 171724 1965 63315297
Radiculopathy 37.17 9.33 76 171684 8535 63308727
Multiple sclerosis relapse 36.98 9.33 46 171714 48432 63268830
Dyspepsia 36.90 9.33 431 171329 101765 63215497
Total lung capacity increased 36.85 9.33 38 171722 2272 63314990
Colitis 36.10 9.33 240 171520 48288 63268974
Personality disorder 36.09 9.33 60 171700 5751 63311511
Cardiac arrest 35.99 9.33 396 171364 92149 63225113
Chronic sinusitis 35.31 9.33 95 171665 12748 63304514
Flatulence 35.08 9.33 186 171574 34516 63282746
Joint swelling 34.95 9.33 650 171110 327016 62990246
Victim of sexual abuse 34.32 9.33 22 171738 662 63316600
Feeding intolerance 34.21 9.33 23 171737 751 63316511
Blood bilirubin increased 34.14 9.33 194 171566 36946 63280316
Vomiting 34.13 9.33 1845 169915 557772 62759490
Dyspnoea 34.09 9.33 1453 170307 659860 62657402
Rib deformity 33.62 9.33 16 171744 263 63316999
Chemical submission 33.46 9.33 16 171744 266 63316996
Female genital tract fistula 32.97 9.33 67 171693 7492 63309770
Hypercholesterolaemia 32.48 9.33 129 171631 21205 63296057
Hypersensitivity 32.34 9.33 577 171183 292108 63025154
Joint range of motion decreased 31.55 9.33 172 171588 32256 63285006
Cholelithiasis 31.34 9.33 215 171545 43710 63273552
Small intestinal obstruction 31.31 9.33 115 171645 18222 63299040
Wrong technique in product usage process 30.53 9.33 78 171682 62262 63255000
Prescribed overdose 30.48 9.33 177 171583 33976 63283286
Salivary gland calculus 30.33 9.33 13 171747 165 63317097
Angioedema 30.23 9.33 52 171708 47913 63269349
Skin haemorrhage 30.14 9.33 77 171683 10017 63307245
Injection site bruising 29.69 9.33 42 171718 41868 63275394
Sputum purulent 29.33 9.33 24 171736 1063 63316199
Therapy cessation 28.80 9.33 24 171736 30433 63286829
Drug resistance 28.73 9.33 13 171747 22920 63294342
Rheumatoid nodule 28.14 9.33 6 171754 17149 63300113
Therapy interrupted 27.81 9.33 28 171732 32427 63284835
Head banging 27.60 9.33 16 171744 400 63316862
Myocardial infarction 27.48 9.33 158 171602 99735 63217527
Large intestine polyp 27.29 9.33 65 171695 8092 63309170
Arteriosclerosis coronary artery 27.24 9.33 66 171694 8307 63308955
Bursitis 26.84 9.33 182 171578 36859 63280403
Fibromyalgia 26.77 9.33 334 171426 80086 63237176
Arthralgia 26.61 9.33 1265 170495 568445 62748817
Arteriovenous fistula occlusion 26.27 9.33 15 171745 364 63316898
Shunt stenosis 26.18 9.33 17 171743 523 63316739
Amnesia 25.98 9.33 247 171513 55338 63261924
Colitis ulcerative 25.79 9.33 139 171621 25952 63291310
Anaphylactic reaction 25.70 9.33 92 171668 66008 63251254
Adjustment disorder with depressed mood 25.60 9.33 73 171687 10131 63307131
COVID-19 25.49 9.33 190 171570 112913 63204349
Drug eruption 25.46 9.33 24 171736 28670 63288592
Decreased appetite 25.46 9.33 873 170887 250179 63067083
Blood cholesterol increased 25.34 9.33 376 171384 93656 63223606
Infection 25.23 9.33 452 171308 228721 63088541
Calciphylaxis 25.09 9.33 36 171724 3036 63314226
Eating disorder 25.05 9.33 110 171650 18906 63298356
Anti-cyclic citrullinated peptide antibody 24.97 9.33 56 171704 6702 63310560
Swollen joint count increased 24.85 9.33 175 171585 35879 63281383
Sinus congestion 24.77 9.33 106 171654 18017 63299245
Haemorrhoids 24.67 9.33 122 171638 22028 63295234
Multiple drug therapy 24.48 9.33 39 171721 3607 63313655
Hyperhidrosis 24.37 9.33 181 171579 107655 63209607
Musculoskeletal disorder 23.90 9.33 13 171747 20631 63296631
Substance abuse 23.87 9.33 45 171715 4762 63312500
Sedation complication 23.87 9.33 87 171673 13735 63303527
Sinusitis 23.41 9.33 452 171308 226201 63091061
Crohn's disease 23.17 9.33 45 171715 4868 63312394
C-reactive protein abnormal 23.14 9.33 208 171552 45888 63271374
Injection site rash 23.04 9.33 11 171749 18798 63298464
Injury 23.02 9.33 301 171459 72946 63244316
Hypercalciuria 23.01 9.33 13 171747 309 63316953
Blue toe syndrome 22.70 9.33 14 171746 393 63316869
Hypoparathyroidism 22.69 9.33 17 171743 661 63316601
Ill-defined disorder 22.65 9.33 129 171631 81626 63235636
Secondary immunodeficiency 22.51 9.33 23 171737 1360 63315902
Incorrect route of product administration 22.41 9.33 139 171621 27313 63289949
Synovitis 22.40 9.33 363 171397 186555 63130707
Peripheral swelling 22.37 9.33 548 171212 265394 63051868
Coordination abnormal 22.37 9.33 85 171675 13688 63303574
Vaginal discharge 22.30 9.33 65 171695 9133 63308129
Nasal polyps 22.27 9.33 50 171710 5989 63311273
Hypokalaemia 21.66 9.33 398 171362 103406 63213856
Obesity 21.60 9.33 147 171613 29805 63287457
Drug ineffective for unapproved indication 21.40 9.33 37 171723 34026 63283236
Drug reaction with eosinophilia and systemic symptoms 21.03 9.33 37 171723 33799 63283463
Abortion spontaneous 20.90 9.33 62 171698 47133 63270129
Heavy menstrual bleeding 20.86 9.33 11 171749 17762 63299500
Drug intolerance 20.83 9.33 656 171104 308005 63009257
Hemiplegia 20.82 9.33 64 171696 9259 63308003
Panniculitis 20.82 9.33 3 171757 11382 63305880
Oedema peripheral 20.73 9.33 665 171095 188846 63128416
Product quality issue 20.72 9.33 41 171719 35824 63281438
Hypophosphataemia 20.65 9.33 73 171687 11353 63305909
Night sweats 20.43 9.33 212 171548 48602 63268660
Blood glucose increased 20.18 9.33 138 171622 83618 63233644
Post procedural diarrhoea 20.16 9.33 15 171745 577 63316685
Bradycardia 20.04 9.33 116 171644 73111 63244151
Stress fracture 20.01 9.33 57 171703 7906 63309356
Abdominal rigidity 19.98 9.33 26 171734 1998 63315264
Weight increased 19.91 9.33 545 171215 260247 63057015
Hepatocellular injury 19.83 9.33 27 171733 27354 63289908
Substance use disorder 19.38 9.33 10 171750 197 63317065
Congestive hepatopathy 19.11 9.33 31 171729 2911 63314351
Infusion related reaction 19.02 9.33 512 171248 245009 63072253
Gastrointestinal sounds abnormal 18.98 9.33 37 171723 4014 63313248
Skin necrosis 18.95 9.33 7 171753 13943 63303319
Sneezing 18.65 9.33 98 171662 18120 63299142
Paraesthesia oral 18.64 9.33 102 171658 19154 63298108
Lymph node palpable 18.56 9.33 8 171752 103 63317159
Intestinal obstruction 18.47 9.33 145 171615 30754 63286508
Hypomagnesaemia 18.37 9.33 137 171623 28600 63288662
Creatinine renal clearance decreased 18.29 9.33 90 171670 16218 63301044
Affect lability 18.26 9.33 69 171691 11082 63306180
Device malfunction 18.25 9.33 13 171747 17844 63299418
Red blood cell sedimentation rate abnormal 18.20 9.33 16 171744 19766 63297496
Protein C increased 18.03 9.33 8 171752 111 63317151
Urine calcium/creatinine ratio increased 17.96 9.33 8 171752 112 63317150
Lower respiratory tract infection 17.89 9.33 251 171509 132056 63185206
Coronary artery disease 17.87 9.33 38 171722 32339 63284923
Myocarditis 17.84 9.33 65 171695 10260 63307002
Abdominal distension 17.68 9.33 331 171429 86284 63230978
Respiratory tract congestion 17.63 9.33 95 171665 17737 63299525
Pneumothorax spontaneous 17.60 9.33 16 171744 818 63316444
Gonorrhoea 17.59 9.33 8 171752 118 63317144
X-ray abnormal 17.49 9.33 55 171705 8055 63309207
Renal tubular necrosis 17.43 9.33 71 171689 11807 63305455
Treatment failure 17.32 9.33 408 171352 198635 63118627
Road traffic accident 17.22 9.33 163 171597 36469 63280793
Loss of personal independence in daily activities 17.21 9.33 174 171586 97116 63220146
Sleep disorder due to a general medical condition 17.21 9.33 72 171688 12116 63305146
Blindness 17.17 9.33 20 171740 21679 63295583
Metabolic alkalosis 16.90 9.33 30 171730 3031 63314231
Rhinorrhoea 16.81 9.33 260 171500 65317 63251945
Acquired haemophilia 16.52 9.33 17 171743 1014 63316248
Product storage error 16.49 9.33 10 171750 14946 63302316
Sensory loss 16.47 9.33 63 171697 10175 63307087
Breast cancer 16.47 9.33 71 171689 48312 63268950
Device difficult to use 16.43 9.33 7 171753 12789 63304473
Tinnitus 16.37 9.33 46 171714 35582 63281680
Osteoarthritis 16.35 9.33 355 171405 94988 63222274
Peripheral pulse decreased 16.33 9.33 6 171754 49 63317213
Weight decreased 16.29 9.33 910 170850 275888 63041374
Maternal exposure during pregnancy 15.99 9.33 463 171297 219599 63097663
Cholestasis 15.86 9.33 35 171725 29399 63287863
Injection site haemorrhage 15.65 9.33 26 171734 24288 63292974
Procedural pain 15.64 9.33 106 171654 21463 63295799
Hospitalisation 15.54 9.33 151 171609 84930 63232332
Type 2 diabetes mellitus 15.53 9.33 251 171509 63617 63253645
Fanconi syndrome 15.52 9.33 19 171741 1373 63315889
Impaired quality of life 15.50 9.33 9 171751 13774 63303488
Nephroangiosclerosis 15.49 9.33 8 171752 158 63317104
Depressed level of consciousness 15.48 9.33 245 171515 61833 63255429
Metamyelocyte count increased 15.42 9.33 9 171751 228 63317034
Skin ulcer 15.38 9.33 62 171698 42983 63274279
Dry mouth 15.36 9.33 296 171464 77567 63239695
Musculoskeletal pain 15.32 9.33 342 171418 91935 63225327
Sarcoidosis 15.08 9.33 48 171712 7074 63310188
Fluid retention 15.05 9.33 97 171663 59589 63257673
Victim of chemical submission 14.89 9.33 12 171748 520 63316742
Mydriasis 14.88 9.33 68 171692 11888 63305374
Inappropriate antidiuretic hormone secretion 14.85 9.33 12 171748 15450 63301812
Discoloured vomit 14.79 9.33 15 171745 879 63316383
Hyperparathyroidism secondary 14.72 9.33 19 171741 1448 63315814
Injection site urticaria 14.71 9.33 10 171750 14063 63303199
Obstructive airways disorder 14.57 9.33 101 171659 20598 63296664
Tendonitis 14.55 9.33 19 171741 19596 63297666
Cardiac failure congestive 14.48 9.33 170 171590 92263 63224999
Gastrointestinal disorder 14.38 9.33 259 171501 130980 63186282
Device dislocation 14.32 9.33 30 171730 25675 63291587
Bronchopulmonary aspergillosis 14.21 9.33 3 171757 8632 63308630
Helicobacter infection 14.21 9.33 340 171420 92445 63224817
Foetal death 14.11 9.33 6 171754 10974 63306288
Ulcer 14.11 9.33 31 171729 26076 63291186
Poisoning deliberate 14.10 9.33 64 171696 11154 63306108
Motor dysfunction 13.99 9.33 62 171698 10699 63306563
Premature delivery 13.98 9.33 39 171721 30242 63287020
Blood pressure fluctuation 13.98 9.33 71 171689 46246 63271016
Substance dependence 13.94 9.33 8 171752 196 63317066
Device issue 13.90 9.33 27 171733 23754 63293508
Drug use disorder 13.84 9.33 37 171723 4947 63312315
Gastrointestinal procedural complication 13.83 9.33 8 171752 199 63317063
Irritability 13.77 9.33 42 171718 31652 63285610
Noninfectious peritonitis 13.70 9.33 7 171753 135 63317127
Homicide 13.66 9.33 10 171750 375 63316887
Accidental exposure to product 13.64 9.33 34 171726 27371 63289891
Burning sensation 13.43 9.33 89 171671 54318 63262944
Flushing 13.40 9.33 134 171626 74953 63242309
Gastric dilatation 13.40 9.33 14 171746 850 63316412
C-reactive protein 13.31 9.33 36 171724 4846 63312416
Gluten sensitivity 13.29 9.33 12 171748 608 63316654
Renal impairment 13.26 9.33 164 171596 88191 63229071
Osteomalacia 13.25 9.33 13 171747 732 63316530
Alcoholic 12.99 9.33 5 171755 47 63317215
Bronchitis 12.93 9.33 249 171511 124686 63192576
Intestinal fibrosis 12.92 9.33 7 171753 153 63317109
Spinal cord injury lumbar 12.81 9.33 5 171755 49 63317213
Product prescribing error 12.79 9.33 33 171727 26256 63291006
Intentional product use issue 12.76 9.33 444 171316 127448 63189814
Hyperparathyroidism 12.75 9.33 25 171735 2724 63314538
Low turnover osteopathy 12.57 9.33 32 171728 4153 63313109
Shunt occlusion 12.57 9.33 12 171748 653 63316609
Leukopenia 12.55 9.33 141 171619 77149 63240113
Intermenstrual bleeding 12.54 9.33 3 171757 7923 63309339
Poliomyelitis 12.47 9.33 5 171755 53 63317209
Periarticular disorder 12.47 9.33 5 171755 53 63317209
Retinitis 12.44 9.33 41 171719 6155 63311107
Induced abortion failed 12.38 9.33 8 171752 244 63317018
Hyperphosphataemia 12.37 9.33 22 171738 2226 63315036
Pathological fracture 12.33 9.33 52 171708 8782 63308480
Oncocytoma 12.23 9.33 4 171756 22 63317240
Illness 12.23 9.33 80 171680 48979 63268283
Labelled drug-drug interaction medication error 12.13 9.33 11 171749 13388 63303874
Psoriasis 12.10 9.33 164 171596 86793 63230469
Toxic epidermal necrolysis 12.04 9.33 113 171647 25221 63292041
Surgery 12.04 9.33 53 171707 35859 63281403
Heart rate increased 11.96 9.33 181 171579 94057 63223205
Hypermagnesaemia 11.88 9.33 14 171746 972 63316290
Electrocardiogram ST segment elevation 11.77 9.33 30 171730 3897 63313365
Myelocyte count increased 11.77 9.33 9 171751 361 63316901
Disease progression 11.70 9.33 248 171512 122510 63194752
Rectal haemorrhage 11.66 9.33 192 171568 48838 63268424
Eye injury 11.59 9.33 25 171735 2914 63314348
Blood ethanol increased 11.55 9.33 6 171754 120 63317142
Therapeutic reaction time decreased 11.54 9.33 22 171738 2348 63314914
Neuralgia 11.52 9.33 34 171726 25892 63291370
Product substitution issue 11.36 9.33 16 171744 15980 63301282
Breast cancer female 11.28 9.33 12 171748 13547 63303715
Hepatic function abnormal 11.17 9.33 57 171703 37085 63280177
Swelling 11.17 9.33 620 171140 274758 63042504
Congenital knee deformity 11.16 9.33 5 171755 71 63317191
Injection site warmth 10.99 9.33 15 171745 15180 63302082
Therapy non-responder 10.98 9.33 276 171484 75625 63241637
Rhinovirus infection 10.97 9.33 32 171728 4497 63312765
Rash pruritic 10.97 9.33 106 171654 59693 63257569
Hip fracture 10.94 9.33 125 171635 29349 63287913
Erythema multiforme 10.93 9.33 7 171753 10162 63307100
Self-injurious ideation 10.93 9.33 23 171737 2636 63314626
Anti-erythropoietin antibody positive 10.88 9.33 9 171751 405 63316857
Fungal infection 10.86 9.33 57 171703 36817 63280445
Vision blurred 10.84 9.33 179 171581 91745 63225517
Postmortem blood drug level 10.84 9.33 6 171754 137 63317125
Red blood cell sedimentation rate increased 10.82 9.33 72 171688 43910 63273352
Arthritis 10.82 9.33 235 171525 115686 63201576
Congenital umbilical hernia 10.81 9.33 8 171752 305 63316957
Insomnia 10.80 9.33 474 171286 214778 63102484
Throat tightness 10.80 9.33 33 171727 24854 63292408
Neoplasm malignant 10.80 9.33 126 171634 29735 63287527
Joint injury 10.79 9.33 125 171635 29447 63287815
Fear of injection 10.79 9.33 3 171757 7161 63310101
Blood urea increased 10.77 9.33 114 171646 26265 63290997
Amputation 10.71 9.33 7 171753 218 63317044
Parathyroid gland enlargement 10.65 9.33 4 171756 35 63317227
Anal incontinence 10.62 9.33 68 171692 13508 63303754
Tenosynovitis 10.61 9.33 13 171747 13782 63303480
Delirium 10.61 9.33 194 171566 50347 63266915
Failure to thrive 10.54 9.33 43 171717 7155 63310107
Oropharyngeal pain 10.50 9.33 186 171574 94301 63222961
Wound infection 10.43 9.33 96 171664 21314 63295948
Sleep apnoea syndrome 10.38 9.33 42 171718 29091 63288171
Tardive dyskinesia 10.37 9.33 5 171755 8497 63308765
Contraindicated product administered 10.37 9.33 482 171278 217166 63100096
Respiratory rate increased 10.35 9.33 13 171747 13635 63303627
Oedema 10.26 9.33 341 171419 97281 63219981
Depression 10.21 9.33 431 171329 196061 63121201
Gangrene 10.12 9.33 38 171722 6085 63311177
Malabsorption 10.09 9.33 29 171731 4043 63313219
Feeling abnormal 10.08 9.33 315 171445 148077 63169185
Impaired work ability 10.07 9.33 20 171740 17455 63299807
Dysarthria 10.06 9.33 167 171593 42544 63274718
Pharyngitis 10.02 9.33 25 171735 20118 63297144
Gastrointestinal stoma complication 10.01 9.33 18 171742 1837 63315425
Oral candidiasis 10.01 9.33 100 171660 22698 63294564
Anti-saccharomyces cerevisiae antibody test positive 10.01 9.33 4 171756 42 63317220
Jaundice acholuric 10.00 9.33 5 171755 92 63317170
Joint stiffness 9.97 9.33 164 171596 41705 63275557
Oxygen saturation decreased 9.96 9.33 174 171586 88411 63228851
Faecalith 9.95 9.33 3 171757 12 63317250
Pharyngo-oesophageal diverticulum 9.95 9.33 3 171757 12 63317250
Complication of device insertion 9.94 9.33 4 171756 7560 63309702
Blood pressure systolic abnormal 9.90 9.33 13 171747 13373 63303889
Screaming 9.86 9.33 25 171735 3237 63314025
Gastroenteritis radiation 9.85 9.33 9 171751 463 63316799
Acute respiratory failure 9.72 9.33 139 171621 34346 63282916
Somnambulism 9.66 9.33 35 171725 5508 63311754
Neuroleptic malignant syndrome 9.66 9.33 11 171749 12045 63305217
Anti-cyclic citrullinated peptide antibody positive 9.61 9.33 240 171520 115972 63201290
Skin exfoliation 9.60 9.33 167 171593 42935 63274327
Lower limb fracture 9.57 9.33 104 171656 24117 63293145
Diverticular perforation 9.54 9.33 26 171734 3516 63313746
Blood ethanol 9.53 9.33 4 171756 48 63317214
Blood creatinine increased 9.53 9.33 308 171452 87536 63229726
Sinus disorder 9.51 9.33 105 171655 24448 63292814
Liver function test increased 9.51 9.33 51 171709 32760 63284502
Abscess soft tissue 9.46 9.33 6 171754 177 63317085
Duodenitis 9.46 9.33 27 171733 3748 63313514
Caesarean section 9.39 9.33 20 171740 17012 63300250
Blood calcium increased 9.37 9.33 50 171710 9300 63307962
Haematotoxicity 9.35 9.33 7 171753 9369 63307893

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2918.65 10.14 2234 86508 96862 34771327
Completed suicide 1887.59 10.14 1732 87010 96436 34771753
Toxicity to various agents 1492.21 10.14 2163 86579 198199 34669990
Cardio-respiratory arrest 400.27 10.14 591 88151 54682 34813507
Alcohol abuse 337.34 10.14 186 88556 4504 34863685
Intentional overdose 332.11 10.14 478 88264 43196 34824993
Alcohol interaction 327.17 10.14 156 88586 2757 34865432
Drug ineffective 248.27 10.14 492 88250 456259 34411930
Overdose 226.69 10.14 623 88119 90436 34777753
Suspected suicide 215.47 10.14 140 88602 4608 34863581
Intentional product misuse 193.77 10.14 385 88357 45226 34822963
Alcohol poisoning 190.72 10.14 117 88625 3476 34864713
Milk-alkali syndrome 187.53 10.14 67 88675 538 34867651
Suicide attempt 159.93 10.14 325 88417 38791 34829398
Drug dependence 155.40 10.14 245 88497 23972 34844217
Substance abuse 138.69 10.14 131 88611 7510 34860679
Exposure to toxic agent 112.17 10.14 85 88657 3590 34864599
Asphyxia 97.84 10.14 103 88639 6732 34861457
Alcohol use 91.51 10.14 72 88670 3216 34864973
Off label use 82.60 10.14 676 88066 418848 34449341
Respiratory depression 74.87 10.14 142 88600 16103 34852086
Poisoning deliberate 73.38 10.14 95 88647 7749 34860440
Coma 70.11 10.14 265 88477 45413 34822776
Blood alcohol increased 68.58 10.14 36 88706 787 34867402
Shunt stenosis 67.43 10.14 35 88707 747 34867442
Myocardial infarction 66.56 10.14 129 88613 120956 34747233
Substance use disorder 61.87 10.14 33 88709 746 34867443
Hypercalcaemia 61.38 10.14 127 88615 15341 34852848
Respiratory arrest 60.09 10.14 182 88560 27861 34840328
Product use in unapproved indication 55.62 10.14 136 88606 117363 34750826
Blood mercury abnormal 54.47 10.14 21 88721 213 34867976
5-hydroxyindolacetic acid in urine increased 52.56 10.14 21 88721 236 34867953
Treatment failure 50.19 10.14 28 88714 46669 34821520
Nasal polyps 47.51 10.14 44 88698 2459 34865730
Fractional exhaled nitric oxide increased 46.88 10.14 31 88711 1051 34867138
Aggression 44.11 10.14 206 88536 38758 34829431
Methaemoglobinaemia 42.64 10.14 49 88693 3532 34864657
Drug hypersensitivity 41.50 10.14 89 88653 80440 34787749
Cardiac arrest 41.29 10.14 399 88343 95760 34772429
Drug resistance 40.98 10.14 8 88734 25919 34842270
Calciphylaxis 39.53 10.14 28 88714 1064 34867125
Drug use disorder 38.02 10.14 50 88692 4141 34864048
Intentional product use issue 37.90 10.14 271 88471 59545 34808644
Prescription drug used without a prescription 37.32 10.14 36 88706 2118 34866071
Diarrhoea 37.06 10.14 1271 87471 388641 34479548
Alcohol withdrawal syndrome 35.98 10.14 30 88712 1456 34866733
Antineutrophil cytoplasmic antibody positive 35.28 10.14 23 88719 761 34867428
Product dose omission issue 34.10 10.14 172 88570 119539 34748650
Poisoning 33.73 10.14 87 88655 12139 34856050
Incorrect route of product administration 33.36 10.14 98 88644 14747 34853442
Therapeutic product effect decreased 32.99 10.14 24 88718 34719 34833470
Alcohol intolerance 32.93 10.14 18 88724 428 34867761
Hungry bone syndrome 32.46 10.14 11 88731 74 34868115
Drug ineffective for unapproved indication 32.27 10.14 10 88732 23705 34844484
Interstitial lung disease 32.11 10.14 74 88668 65208 34802981
Granulomatous pneumonitis 31.92 10.14 9 88733 29 34868160
Hyperparathyroidism secondary 30.61 10.14 28 88714 1540 34866649
Plantar fasciitis 30.48 10.14 32 88710 2084 34866105
Chronic sinusitis 30.25 10.14 33 88709 2246 34865943
Small intestinal obstruction 29.54 10.14 94 88648 14772 34853417
Ex-drug abuser 29.48 10.14 12 88730 142 34868047
Intentional self-injury 29.14 10.14 89 88653 13682 34854507
Proctalgia 28.84 10.14 52 88690 5671 34862518
Drug withdrawal syndrome 27.92 10.14 112 88630 19722 34848467
Low density lipoprotein decreased 27.52 10.14 23 88719 1120 34867069
Miosis 27.50 10.14 69 88673 9466 34858723
Rheumatoid arthritis 27.43 10.14 34 88708 38204 34829985
Respiratory symptom 27.37 10.14 28 88714 1769 34866420
Mydriasis 27.06 10.14 58 88684 7179 34861010
Shunt occlusion 26.28 10.14 20 88722 850 34867339
Pouchitis 25.67 10.14 18 88724 673 34867516
Drug intolerance 25.09 10.14 73 88669 59497 34808692
Accidental death 24.96 10.14 31 88711 2425 34865764
Myoglobin blood increased 24.29 10.14 34 88708 2989 34865200
Ileus 23.89 10.14 94 88648 16405 34851784
Hypocalcaemia 23.62 10.14 123 88619 24166 34844023
Nephrogenic systemic fibrosis 23.60 10.14 39 88703 3966 34864223
Sensation of foreign body 23.41 10.14 32 88710 2751 34865438
Rash 22.84 10.14 413 88329 222339 34645850
Open reduction of fracture 22.70 10.14 9 88733 99 34868090
Oesophageal perforation 22.61 10.14 21 88721 1178 34867011
Dehydration 22.24 10.14 458 88284 129511 34738678
Angioedema 22.13 10.14 38 88704 37336 34830853
Alcoholism 21.84 10.14 32 88710 2933 34865256
Myelosuppression 21.50 10.14 11 88731 19254 34848935
Soft tissue mass 21.47 10.14 19 88723 1000 34867189
Disease progression 21.18 10.14 174 88568 107903 34760286
Atypical fracture 21.15 10.14 9 88733 120 34868069
Multimorbidity 20.73 10.14 18 88724 924 34867265
Cardiac failure 20.69 10.14 141 88601 91107 34777082
Metabolic alkalosis 20.39 10.14 22 88720 1479 34866710
Blood parathyroid hormone increased 20.23 10.14 22 88720 1492 34866697
Foetal alcohol syndrome 20.14 10.14 9 88733 136 34868053
Drug screen positive 20.09 10.14 36 88706 3907 34864282
Condition aggravated 19.80 10.14 356 88386 191840 34676349
Foetal exposure during pregnancy 19.71 10.14 42 88700 38059 34830130
Calcinosis 19.58 10.14 16 88726 755 34867434
Depressed level of consciousness 19.48 10.14 180 88562 42661 34825528
Enterocolonic fistula 19.41 10.14 8 88734 98 34868091
Growth hormone deficiency 19.34 10.14 11 88731 283 34867906
Anal inflammation 19.34 10.14 20 88722 1280 34866909
Musculoskeletal stiffness 19.08 10.14 58 88684 46622 34821567
Synovitis 19.01 10.14 6 88736 14060 34854129
Opiates positive 18.98 10.14 14 88728 567 34867622
Anaphylactic reaction 18.98 10.14 33 88709 32268 34835921
Haematopoietic stem cell mobilisation 18.62 10.14 9 88733 164 34868025
Pulmonary vasculitis 18.60 10.14 14 88728 585 34867604
N-telopeptide urine increased 18.15 10.14 6 88736 37 34868152
Blood ethanol 17.95 10.14 8 88734 120 34868069
Colitis 17.87 10.14 160 88582 37590 34830599
Joint swelling 17.64 10.14 85 88657 59805 34808384
SARS-CoV-2 test negative 17.58 10.14 17 88725 1003 34867186
Hypophosphatasia 17.50 10.14 6 88736 42 34868147
Gastrointestinal obstruction 17.47 10.14 16 88726 881 34867308
Chest pain 17.44 10.14 222 88520 126540 34741649
Brain natriuretic peptide increased 17.43 10.14 42 88700 5617 34862572
Erythema 17.36 10.14 143 88599 88637 34779552
Enterocolitis bacterial 17.28 10.14 11 88731 349 34867840
Nerve degeneration 17.05 10.14 9 88733 199 34867990
Hepatic neoplasm 17.03 10.14 23 88719 1954 34866235
Type 2 diabetes mellitus 16.67 10.14 10 88732 16022 34852167
Injection site erythema 16.41 10.14 10 88732 15889 34852300
Weight increased 16.36 10.14 154 88588 92879 34775310
Secretion discharge 16.27 10.14 42 88700 5863 34862326
Vascular device infection 16.18 10.14 34 88708 4151 34864038
Electrocardiogram QT prolonged 16.14 10.14 167 88575 40785 34827404
Psoriasis 16.02 10.14 48 88694 38764 34829425
Intestinal obstruction 15.98 10.14 106 88636 22716 34845473
Bladder cancer 15.77 10.14 11 88731 16267 34851922
Metabolic acidosis 15.76 10.14 175 88567 43505 34824684
Renal impairment 15.55 10.14 159 88583 94354 34773835
Renal tubular dysfunction 15.46 10.14 11 88731 421 34867768
Sleep disorder due to a general medical condition 15.28 10.14 38 88704 5183 34863006
Tachycardia 15.24 10.14 301 88441 84471 34783718
Dextrocardia 15.14 10.14 7 88735 115 34868074
Therapy partial responder 15.13 10.14 3 88739 9613 34858576
Abdominal distension 15.00 10.14 220 88522 58272 34809917
Urogenital fistula 14.94 10.14 3 88739 0 34868189
Accident at work 14.85 10.14 14 88728 800 34867389
Homicide 14.84 10.14 15 88727 934 34867255
Diabetes mellitus 14.71 10.14 65 88677 46808 34821381
Impaired driving ability 14.66 10.14 25 88717 2608 34865581
Wrong technique in product usage process 14.50 10.14 45 88697 35941 34832248
Bone density decreased 14.47 10.14 21 88721 1908 34866281
Arthropathy 14.47 10.14 29 88713 26878 34841311
Therapy non-responder 14.37 10.14 51 88691 39095 34829094
Fatty liver alcoholic 14.31 10.14 6 88736 77 34868112
Respiratory tract infection bacterial 14.25 10.14 20 88722 1762 34866427
Multiple organ dysfunction syndrome 14.22 10.14 125 88617 76441 34791748
Physical assault 14.20 10.14 16 88726 1129 34867060
Withdrawal syndrome 14.20 10.14 66 88676 12389 34855800
Red blood cell count decreased 14.13 10.14 124 88618 28966 34839223
Blood pressure diastolic increased 14.11 10.14 36 88706 4989 34863200
Crohn's disease 14.05 10.14 27 88715 3090 34865099
Headache 13.74 10.14 396 88346 200239 34667950
Infection 13.73 10.14 156 88586 90759 34777430
Dizziness 13.57 10.14 437 88305 218084 34650105
Substance-induced mood disorder 13.41 10.14 6 88736 91 34868098
Sensorimotor disorder 13.00 10.14 10 88732 432 34867757
Accident 12.99 10.14 35 88707 5012 34863177
Peripheral swelling 12.90 10.14 128 88614 76413 34791776
Visceral oedema 12.90 10.14 6 88736 100 34868089
Macrognathia 12.86 10.14 3 88739 3 34868186
Neuroleptic malignant syndrome 12.80 10.14 16 88726 17918 34850271
Cirrhosis alcoholic 12.61 10.14 13 88729 829 34867360
Central nervous system mass 12.60 10.14 7 88735 172 34868017
Bilirubin conjugated abnormal 12.58 10.14 6 88736 106 34868083
Gastrointestinal sounds abnormal 12.58 10.14 21 88721 2154 34866035
Blood calcium increased 12.52 10.14 28 88714 3566 34864623
Wall motion score index abnormal 12.49 10.14 7 88735 175 34868014
Abscess intestinal 12.47 10.14 18 88724 1628 34866561
Femur fracture 12.34 10.14 47 88695 8077 34860112
Therapy interrupted 12.31 10.14 10 88732 13687 34854502
Amnesia 12.27 10.14 112 88630 26451 34841738
Drug reaction with eosinophilia and systemic symptoms 12.12 10.14 43 88699 32969 34835220
Product prescribing error 12.08 10.14 25 88717 22902 34845287
Blood albumin decreased 12.02 10.14 67 88675 13505 34854684
Myocardial fibrosis 11.99 10.14 15 88727 1182 34867007
Drug eruption 11.99 10.14 20 88722 19878 34848311
Frequent bowel movements 11.91 10.14 64 88678 12723 34855466
Blood ethanol increased 11.86 10.14 10 88732 493 34867696
Postmortem blood drug level 11.84 10.14 7 88735 194 34867995
Delirium tremens 11.81 10.14 11 88731 619 34867570
Shunt aneurysm 11.79 10.14 4 88738 27 34868162
Colitis ulcerative 11.73 10.14 77 88665 16443 34851746
Acute myocardial infarction 11.68 10.14 84 88658 53635 34814554
Psychiatric disorder prophylaxis 11.66 10.14 5 88737 68 34868121
Calcification metastatic 11.66 10.14 3 88739 6 34868183
Behavioural addiction 11.60 10.14 5 88737 69 34868120
Respiratory tract infection viral 11.59 10.14 22 88720 2495 34865694
Premature baby 11.58 10.14 20 88722 19613 34848576
Coma scale abnormal 11.55 10.14 29 88713 3979 34864210
Mean cell haemoglobin 11.55 10.14 4 88738 29 34868160
Necrotising ulcerative gingivostomatitis 11.53 10.14 5 88737 70 34868119
Urticaria 11.51 10.14 102 88640 62275 34805914
Neuritis 11.49 10.14 13 88729 921 34867268
Cerebrovascular accident 11.48 10.14 149 88593 84662 34783527
Blood immunoglobulin E increased 11.41 10.14 22 88720 2524 34865665
Immune reconstitution inflammatory syndrome 11.38 10.14 4 88738 8755 34859434
Chronic respiratory failure 11.37 10.14 16 88726 1413 34866776
Product quality issue 11.34 10.14 16 88726 17019 34851170
Arthralgia 11.29 10.14 337 88405 169704 34698485
Bronchial obstruction 11.27 10.14 17 88725 1599 34866590
Amphetamines positive 11.23 10.14 7 88735 214 34867975
SARS-CoV-2 antibody test positive 11.19 10.14 9 88733 415 34867774
Systemic inflammatory response syndrome 11.19 10.14 40 88702 6669 34861520
Injection site bruising 11.18 10.14 4 88738 8659 34859530
Hepatocellular injury 11.06 10.14 25 88717 22186 34846003
Diabetic ketoacidosis 10.98 10.14 18 88724 18014 34850175
Psoriatic arthropathy 10.94 10.14 21 88721 19777 34848412
Hepatic fibrosis 10.92 10.14 31 88711 4576 34863613
Carcinoid tumour of the small bowel 10.86 10.14 7 88735 227 34867962
Hepatic function abnormal 10.84 10.14 67 88675 44296 34823893
Drug abuser 10.76 10.14 28 88714 3926 34864263
Airway remodelling 10.73 10.14 7 88735 232 34867957
Flatulence 10.63 10.14 91 88651 21107 34847082
Injection site pain 10.55 10.14 57 88685 38948 34829241
Tendonitis 10.53 10.14 5 88737 9135 34859054
Pancytopenia 10.51 10.14 174 88568 94983 34773206
Exostosis 10.44 10.14 31 88711 4692 34863497
Road traffic accident 10.43 10.14 78 88664 17372 34850817
Atopy 10.39 10.14 7 88735 245 34867944
Knee arthroplasty 10.38 10.14 3 88739 7441 34860748
Superinfection 10.37 10.14 21 88721 2498 34865691
Cytomegalovirus infection 10.31 10.14 33 88709 26102 34842087
Alcoholic liver disease 10.23 10.14 10 88732 598 34867591
Lymphoma 10.20 10.14 10 88732 12497 34855692

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3836.00 9.47 3947 207742 241820 79290879
Drug abuse 3303.26 9.47 3021 208668 159670 79373029
Toxicity to various agents 2311.90 9.47 4060 207629 417480 79115219
Cardio-respiratory arrest 765.42 9.47 1174 210515 107336 79425363
Milk-alkali syndrome 500.46 9.47 175 211514 1245 79531454
Alcohol interaction 494.52 9.47 247 211442 4627 79528072
Intentional overdose 451.28 9.47 919 210770 105041 79427658
Drug ineffective 428.35 9.47 1459 210230 1079454 78453245
Suspected suicide 351.37 9.47 262 211427 10314 79522385
Alcohol abuse 319.23 9.47 191 211498 5172 79527527
Overdose 308.17 9.47 1132 210557 183074 79349625
Alcohol poisoning 256.99 9.47 160 211529 4661 79528038
Exposure to toxic agent 198.75 9.47 177 211512 8981 79523718
Intentional product misuse 198.67 9.47 630 211059 94535 79438164
Suicide attempt 175.83 9.47 552 211137 82380 79450319
Coma 168.54 9.47 619 211070 100030 79432669
Alcohol use 150.11 9.47 115 211574 4716 79527983
Respiratory arrest 139.86 9.47 402 211287 57148 79475551
Asphyxia 139.77 9.47 164 211525 11556 79521143
Liver injury 129.47 9.47 387 211302 56227 79476472
Drug dependence 118.29 9.47 304 211385 40465 79492234
Substance abuse 115.20 9.47 141 211548 10385 79522314
Hypercalcaemia 115.08 9.47 290 211399 38140 79494559
Hypocalcaemia 110.15 9.47 337 211352 49587 79483112
Hypomania 107.81 9.47 116 211573 7428 79525271
Product dose omission issue 99.38 9.47 331 211358 247206 79285493
Methaemoglobinaemia 94.85 9.47 94 211595 5463 79527236
Myocardial infarction 93.33 9.47 220 211469 183909 79348790
Blood alcohol increased 92.70 9.47 52 211637 1243 79531456
Shunt stenosis 89.23 9.47 52 211637 1339 79531360
Off label use 89.01 9.47 1787 209902 905428 78627271
Facet joint syndrome 81.98 9.47 124 211565 11178 79521521
Drug hypersensitivity 80.25 9.47 465 211224 298451 79234248
Schizophrenia 79.22 9.47 145 211544 15295 79517404
Lip dry 78.10 9.47 144 211545 15274 79517425
Gastrooesophageal reflux disease 78.04 9.47 509 211180 103737 79428962
Jaundice cholestatic 77.90 9.47 121 211568 11163 79521536
Substance use disorder 73.56 9.47 40 211649 898 79531801
Pneumonia aspiration 71.16 9.47 359 211330 66608 79466091
Nasal polyps 70.42 9.47 92 211597 7235 79525464
Poisoning deliberate 69.31 9.47 154 211535 18674 79514025
Drug resistance 68.96 9.47 14 211675 42199 79490500
Peripheral venous disease 67.66 9.47 138 211551 15771 79516928
Cardiac arrest 66.38 9.47 724 210965 171372 79361327
Myelosuppression 64.52 9.47 14 211675 40282 79492417
Rheumatic fever 64.27 9.47 194 211495 28331 79504368
Chronic sinusitis 61.43 9.47 118 211571 12908 79519791
Injection site erythema 59.39 9.47 72 211617 78125 79454574
Incorrect route of product administration 58.58 9.47 215 211474 34714 79497985
Nasal obstruction 57.54 9.47 47 211642 2117 79530582
Neurologic neglect syndrome 56.85 9.47 53 211636 2854 79529845
Nephrocalcinosis 56.22 9.47 40 211649 1462 79531237
Drug ineffective for unapproved indication 54.90 9.47 34 211655 51204 79481495
Deep vein thrombosis postoperative 53.93 9.47 100 211589 10652 79522047
Angioedema 53.63 9.47 74 211615 75961 79456738
Blood mercury abnormal 53.56 9.47 21 211668 213 79532486
Small intestinal obstruction 52.77 9.47 176 211513 27096 79505603
Rash 52.77 9.47 1152 210537 577206 78955493
Calciphylaxis 52.18 9.47 57 211632 3713 79528986
5-hydroxyindolacetic acid in urine increased 51.49 9.47 21 211668 238 79532461
Injection site pain 50.45 9.47 176 211513 129662 79403037
Blood calcium decreased 50.15 9.47 192 211497 31627 79501072
Anaphylactic reaction 50.07 9.47 91 211598 83652 79449047
Throat clearing 49.25 9.47 47 211642 2607 79530092
Recalled product 49.18 9.47 31 211658 923 79531776
Carotid artery thrombosis 49.09 9.47 50 211639 3003 79529696
Calcium ionised decreased 48.74 9.47 26 211663 561 79532138
Segmental diverticular colitis 48.39 9.47 18 211671 156 79532543
Device expulsion 48.04 9.47 6 211683 25855 79506844
Diarrhoea 47.85 9.47 2823 208866 877666 78655033
Hepatotoxicity 46.85 9.47 264 211425 51088 79481611
Pedal pulse abnormal 46.49 9.47 18 211671 176 79532523
Postmortem blood drug level abnormal 46.11 9.47 26 211663 628 79532071
Headache 45.49 9.47 1355 210334 652417 78880282
Drug use disorder 45.34 9.47 82 211607 8569 79524130
Wheezing 43.68 9.47 488 211201 116176 79416523
Abdominal pain 43.66 9.47 1348 210341 388221 79144478
Swollen joint count increased 42.63 9.47 146 211543 22781 79509918
Pruritus 42.30 9.47 765 210924 393883 79138816
Feeding intolerance 41.98 9.47 27 211662 833 79531866
Injection site swelling 41.85 9.47 38 211651 47094 79485605
Full blood count abnormal 41.61 9.47 215 211474 40259 79492440
Coronary artery disease 41.09 9.47 69 211620 65405 79467294
Sleep disorder due to a general medical condition 40.93 9.47 106 211583 14171 79518528
Intentional product use issue 40.32 9.47 597 211092 151515 79381184
Injection site bruising 40.20 9.47 30 211659 40972 79491727
Injection site reaction 39.97 9.47 52 211637 54733 79477966
Product use in unapproved indication 38.85 9.47 451 211238 249908 79282791
Vomiting 38.25 9.47 2146 209543 663682 78869017
Adjustment disorder 38.09 9.47 50 211639 3950 79528749
Alcoholism 37.75 9.47 48 211641 3675 79529024
Total lung capacity increased 37.61 9.47 38 211651 2260 79530439
Joint range of motion decreased 37.18 9.47 181 211508 33101 79499598
Autoimmune disorder 36.50 9.47 112 211577 16500 79516199
Somnolence 36.49 9.47 861 210828 238120 79294579
Injection site pruritus 36.47 9.47 35 211654 42248 79490451
Dyspnoea 36.28 9.47 1883 209806 855142 78677557
Hypophosphataemic osteomalacia 35.80 9.47 18 211671 342 79532357
Personality disorder 35.77 9.47 61 211628 6085 79526614
Hungry bone syndrome 35.36 9.47 15 211674 189 79532510
Respiratory depression 35.09 9.47 156 211533 27474 79505225
Metabolic alkalosis 35.07 9.47 51 211638 4438 79528261
Drug eruption 34.92 9.47 39 211650 43896 79488803
Hepatocellular injury 34.90 9.47 45 211644 47548 79485151
Drug reaction with eosinophilia and systemic symptoms 34.78 9.47 74 211615 64170 79468529
Hyperparathyroidism secondary 34.71 9.47 39 211650 2621 79530078
Wrong technique in product usage process 34.50 9.47 92 211597 73783 79458916
Shunt occlusion 34.50 9.47 30 211659 1474 79531225
Dehydration 34.25 9.47 882 210807 247305 79285394
Chemical submission 33.95 9.47 17 211672 320 79532379
Colitis 33.80 9.47 320 211369 72987 79459712
Pain 33.75 9.47 1526 210163 702276 78830423
Rib deformity 33.39 9.47 15 211674 219 79532480
Frequent bowel movements 32.54 9.47 160 211529 29379 79503320
Rheumatoid nodule 32.50 9.47 4 211685 17434 79515265
Herpes zoster 32.37 9.47 132 211557 92951 79439748
Lupus vulgaris 32.14 9.47 42 211647 3304 79529395
Arthralgia 32.01 9.47 1218 210471 570585 78962114
Poisoning 30.83 9.47 141 211548 25131 79507568
Mydriasis 30.77 9.47 110 211579 17533 79515166
Renal impairment 30.35 9.47 270 211419 157513 79375186
Infection 29.98 9.47 456 211233 241256 79291443
Depressed level of consciousness 29.92 9.47 390 211299 96262 79436437
Intentional self-injury 29.79 9.47 167 211522 32252 79500447
Therapeutic product effect decreased 29.54 9.47 285 211404 163578 79369121
Aggression 29.53 9.47 234 211455 50724 79481975
Cholelithiasis 29.53 9.47 240 211449 52424 79480275
Macular degeneration 29.48 9.47 81 211608 11215 79521484
Multiple sclerosis relapse 29.23 9.47 49 211640 46484 79486215
Interstitial lung disease 29.20 9.47 177 211512 112423 79420276
Disease progression 29.02 9.47 331 211358 184031 79348668
Amnesia 28.94 9.47 275 211414 62782 79469917
Alcohol withdrawal syndrome 28.87 9.47 31 211658 1980 79530719
Erythema 28.82 9.47 418 211271 222872 79309827
Therapy cessation 28.08 9.47 35 211654 37527 79495172
Nicotine dependence 28.07 9.47 22 211667 933 79531766
Haemorrhoids 28.07 9.47 152 211537 28976 79503723
Nephrogenic systemic fibrosis 28.07 9.47 55 211634 6105 79526594
Psychotic disorder 27.89 9.47 197 211492 41205 79491494
X-ray abnormal 27.83 9.47 53 211636 5760 79526939
Arteriosclerosis coronary artery 27.66 9.47 107 211582 17709 79514990
Tetany 27.39 9.47 35 211654 2693 79530006
Asthma-chronic obstructive pulmonary disease overlap syndrome 27.23 9.47 38 211651 3183 79529516
Abdominal rigidity 26.96 9.47 37 211652 3051 79529648
Accidental death 26.85 9.47 44 211645 4247 79528452
Blood ethanol 26.84 9.47 12 211677 173 79532526
Bursitis 26.80 9.47 175 211514 35669 79497030
Victim of sexual abuse 26.71 9.47 17 211672 515 79532184
Granulomatous pneumonitis 26.55 9.47 10 211679 90 79532609
Arteriovenous fistula occlusion 26.14 9.47 17 211672 535 79532164
Stress fracture 26.13 9.47 55 211634 6425 79526274
Dyspepsia 25.89 9.47 419 211270 108268 79424431
Vaginal flatulence 25.79 9.47 33 211656 2542 79530157
Prescription drug used without a prescription 25.72 9.47 42 211647 4043 79528656
Joint swelling 25.66 9.47 577 211112 288069 79244630
Adjustment disorder with depressed mood 25.58 9.47 67 211622 9019 79523680
Road traffic accident 25.58 9.47 201 211488 43463 79489236
Low density lipoprotein decreased 25.31 9.47 23 211666 1198 79531501
Rhinorrhoea 25.26 9.47 311 211378 75763 79456936
Opiates positive 25.02 9.47 21 211668 983 79531716
Neuroleptic malignant syndrome 24.73 9.47 22 211667 27537 79505162
Hepatic function abnormal 24.59 9.47 105 211584 73002 79459697
Drug intolerance 24.32 9.47 525 211164 263594 79269105
Gonorrhoea 24.15 9.47 12 211677 222 79532477
Low turnover osteopathy 24.03 9.47 28 211661 1958 79530741
Product prescribing error 23.94 9.47 52 211637 44761 79487938
Blood parathyroid hormone increased 23.86 9.47 37 211652 3408 79529291
Haematotoxicity 23.64 9.47 6 211683 15513 79517186
Inappropriate antidiuretic hormone secretion 23.62 9.47 21 211668 26292 79506407
Bone marrow failure 23.60 9.47 64 211625 51043 79481656
Musculoskeletal disorder 23.30 9.47 14 211675 21434 79511265
Pouchitis 23.24 9.47 20 211669 969 79531730
Flatulence 23.04 9.47 193 211496 42531 79490168
Gastrointestinal sounds abnormal 22.94 9.47 47 211642 5388 79527311
Skin haemorrhage 22.89 9.47 77 211612 11904 79520795
Anti-cyclic citrullinated peptide antibody 22.83 9.47 49 211640 5803 79526896
Salivary gland calculus 22.74 9.47 12 211677 253 79532446
Vision blurred 22.72 9.47 176 211513 105722 79426977
Therapy interrupted 22.60 9.47 30 211659 31311 79501388
Weight increased 22.57 9.47 562 211127 276824 79255875
Peripheral swelling 22.55 9.47 544 211145 269073 79263626
Amphetamines positive 22.51 9.47 13 211676 329 79532370
Treatment failure 22.39 9.47 318 211371 170168 79362531
Cytomegalovirus infection 22.35 9.47 50 211639 42594 79490105
Postmortem blood drug level 22.30 9.47 13 211676 335 79532364
Cardiac failure congestive 22.27 9.47 256 211433 142146 79390553
Fibromyalgia 22.22 9.47 265 211424 64075 79468624
Affect lability 22.08 9.47 73 211616 11186 79521513
Homicide 22 9.47 21 211668 1165 79531534
Multiple drug therapy 21.81 9.47 39 211650 4039 79528660
Leukopenia 21.69 9.47 201 211488 116312 79416387
Product storage error 21.61 9.47 8 211681 16218 79516481
Abortion spontaneous 21.53 9.47 28 211661 29479 79503220
Sputum purulent 21.52 9.47 22 211667 1327 79531372
Tendonitis 21.41 9.47 19 211670 23811 79508888
Fluid retention 21.25 9.47 104 211585 69705 79462994
Venoocclusive liver disease 21.22 9.47 3 211686 11768 79520931
Red blood cell sedimentation rate abnormal 20.99 9.47 15 211674 20948 79511751
Therapy partial responder 20.89 9.47 10 211679 17387 79515312
Bladder cancer 20.86 9.47 13 211676 19513 79513186
Alcohol intolerance 20.70 9.47 14 211675 471 79532228
Blindness 20.64 9.47 27 211662 28356 79504343
Hypophosphataemia 20.62 9.47 106 211583 19807 79512892
Post transplant lymphoproliferative disorder 20.48 9.47 3 211686 11461 79521238
Blood ethanol increased 20.45 9.47 16 211673 677 79532022
Antineutrophil cytoplasmic antibody positive 20.29 9.47 21 211668 1285 79531414
Helicobacter infection 20.22 9.47 278 211411 69426 79463273
Psoriatic arthropathy 20.21 9.47 305 211384 77694 79455005
Open reduction of fracture 20.11 9.47 11 211678 250 79532449
Abdominal distension 20.09 9.47 437 211252 119213 79413486
Blood bilirubin increased 19.97 9.47 266 211423 65966 79466733
Sinus congestion 19.97 9.47 105 211584 19791 79512908
Injury 19.68 9.47 302 211387 77194 79455505
Thrombocytopenia 19.58 9.47 545 211144 264714 79267985
Sedation complication 19.54 9.47 88 211601 15581 79517118
Condition aggravated 19.45 9.47 1110 210579 500014 79032685
Device malfunction 19.39 9.47 17 211672 21431 79511268
Head banging 19.32 9.47 14 211675 527 79532172
Cerebral haemorrhage 19.29 9.47 83 211606 57590 79475109
Neutropenia 19.27 9.47 599 211090 287111 79245588
Coordination abnormal 19.23 9.47 94 211595 17218 79515481
Injection site rash 19.11 9.47 12 211677 17942 79514757
Hyperhidrosis 19.05 9.47 285 211404 151207 79381492
COVID-19 19.02 9.47 299 211390 157375 79375324
Intestinal obstruction 18.94 9.47 186 211503 42834 79489865
Proctalgia 18.87 9.47 64 211625 9937 79522762
Device difficult to use 18.86 9.47 6 211683 13379 79519320
Hyperparathyroidism 18.76 9.47 32 211657 3192 79529507
Anal inflammation 18.72 9.47 21 211668 1409 79531290
Multimorbidity 18.61 9.47 21 211668 1418 79531281
Eating disorder 18.61 9.47 106 211583 20591 79512108
Blood cholesterol increased 18.56 9.47 319 211370 83401 79449298
Cardiac failure 18.55 9.47 294 211395 154548 79378151
Paraesthesia oral 18.51 9.47 105 211584 20366 79512333
Miosis 18.46 9.47 87 211602 15702 79516997
Pancytopenia 18.45 9.47 319 211370 165426 79367273
Diabetes mellitus 18.40 9.47 127 211562 78263 79454436
Infusion related reaction 18.31 9.47 468 211221 229769 79302930
Failure to thrive 18.28 9.47 71 211618 11773 79520926
Blue toe syndrome 18.21 9.47 14 211675 577 79532122
Night sweats 18.18 9.47 215 211474 51880 79480819
Sleep apnoea syndrome 18.13 9.47 44 211645 36434 79496265
Therapeutic reaction time decreased 18.11 9.47 33 211656 3468 79529231
Red blood cell sedimentation rate increased 18.02 9.47 62 211627 45880 79486819
Substance dependence 17.90 9.47 13 211676 491 79532208
Ileus 17.82 9.47 125 211564 26086 79506613
Bradycardia 17.75 9.47 253 211436 135304 79397395
Multiple organ dysfunction syndrome 17.72 9.47 219 211470 120027 79412672
Cerebral infarction 17.67 9.47 62 211627 45614 79487085
Visual acuity reduced 17.63 9.47 32 211657 29437 79503262
Electrocardiogram QRS complex prolonged 17.59 9.47 66 211623 10767 79521932
Obesity 17.54 9.47 156 211533 34969 79497730
Procedural pain 17.44 9.47 113 211576 22971 79509728
Acute graft versus host disease 17.40 9.47 3 211686 10164 79522535
N-telopeptide urine increased 17.36 9.47 6 211683 41 79532658
Intramedullary rod insertion 17.35 9.47 9 211680 183 79532516
Hypokalaemia 17.33 9.47 503 211186 143537 79389162
Colitis ulcerative 17.19 9.47 154 211535 34588 79498111
Nephroangiosclerosis 17.14 9.47 11 211678 338 79532361
Gastrointestinal disorder 17.10 9.47 225 211464 121980 79410719
Insomnia 17.01 9.47 508 211181 244662 79288037
Injection site haemorrhage 16.91 9.47 30 211659 27840 79504859
Feeling abnormal 16.89 9.47 309 211380 158890 79373809
Product quality issue 16.82 9.47 41 211648 33899 79498800
Neuralgia 16.81 9.47 40 211649 33344 79499355
Victim of chemical submission 16.80 9.47 13 211676 541 79532158
Urine calcium/creatinine ratio increased 16.50 9.47 8 211681 140 79532559
Breast cancer female 16.40 9.47 5 211684 11456 79521243
Haematopoietic stem cell mobilisation 16.35 9.47 9 211680 207 79532492
Death 16.33 9.47 1730 209959 564784 78967915
Vascular device infection 16.19 9.47 62 211627 10214 79522485
Blood pressure fluctuation 16.15 9.47 108 211581 67037 79465662
Hypoparathyroidism 15.89 9.47 17 211672 1081 79531618
Enterocolonic fistula 15.72 9.47 8 211681 156 79532543
Proctitis 15.69 9.47 45 211644 6387 79526312
Oesophageal perforation 15.53 9.47 20 211669 1551 79531148
Delirium tremens 15.49 9.47 14 211675 724 79531975
Sensory loss 15.49 9.47 72 211617 12919 79519780
Protein C increased 15.47 9.47 7 211682 104 79532595
Hypophosphatasia 15.47 9.47 6 211683 59 79532640
Hip arthroplasty 15.45 9.47 154 211535 35602 79497097
Diplopia 15.38 9.47 42 211647 33424 79499275
Soft tissue mass 15.32 9.47 18 211671 1270 79531429
Lymph node palpable 15.19 9.47 8 211681 168 79532531
Cholestasis 15.08 9.47 79 211610 52030 79480669
Granuloma skin 15.07 9.47 3 211686 9171 79523528
Impaired work ability 15.07 9.47 18 211671 19663 79513036
Growth hormone deficiency 15.04 9.47 11 211678 420 79532279
Ulcer 15.02 9.47 36 211653 29936 79502763
Hypersensitivity 14.98 9.47 557 211132 261682 79271017
Agranulocytosis 14.94 9.47 65 211624 44965 79487734
Hepatic neoplasm 14.90 9.47 30 211659 3396 79529303
Discoloured vomit 14.90 9.47 19 211670 1459 79531240
Device issue 14.86 9.47 31 211658 27077 79505622
Depression 14.84 9.47 450 211239 216340 79316359
Burning sensation 14.76 9.47 93 211596 58539 79474160
Polyarthritis 14.67 9.47 7 211682 12195 79520504
Unevaluable event 14.60 9.47 87 211602 55498 79477201
Duodenal ulcer perforation 14.57 9.47 252 211437 65959 79466740
Heart rate increased 14.53 9.47 229 211460 120495 79412204
Toxicologic test abnormal 14.53 9.47 18 211671 1342 79531357
Congestive hepatopathy 14.33 9.47 35 211654 4512 79528187
C-reactive protein 14.31 9.47 37 211652 4942 79527757
Hospitalisation 14.12 9.47 171 211518 94065 79438634
Heavy menstrual bleeding 14.06 9.47 10 211679 14001 79518698
Shunt aneurysm 14.01 9.47 5 211684 38 79532661
Nerve degeneration 13.87 9.47 9 211680 282 79532417
Arthritis 13.80 9.47 218 211471 114662 79418037
Bronchitis 13.72 9.47 254 211435 130390 79402309
Breast cancer 13.65 9.47 45 211644 33736 79498963
Gastrointestinal procedural complication 13.56 9.47 8 211681 211 79532488
Epstein-Barr virus infection 13.56 9.47 11 211678 14405 79518294
Blood glucose increased 13.54 9.47 219 211470 114756 79417943
Sneezing 13.46 9.47 94 211595 19589 79513110
Ill-defined disorder 13.43 9.47 111 211578 65764 79466935
Diabetic ketoacidosis 13.42 9.47 46 211643 34076 79498623
Dry mouth 13.37 9.47 317 211372 87702 79444997
Skin necrosis 13.37 9.47 17 211672 18070 79514629
Constipation 13.33 9.47 897 210792 282153 79250546
Lactic acidosis 13.26 9.47 121 211568 70238 79462461
Pulmonary vasculitis 13.22 9.47 13 211676 748 79531951
Ankylosing spondylitis 13.21 9.47 8 211681 12197 79520502
Myelodysplastic syndrome 13.21 9.47 39 211650 30262 79502437
Injection site urticaria 13.07 9.47 9 211680 12817 79519882
Injection site warmth 13.07 9.47 12 211677 14795 79517904
Prescribed overdose 13.07 9.47 156 211533 37727 79494972
Acute myocardial infarction 13.04 9.47 136 211553 76900 79455799
Gluten sensitivity 12.99 9.47 10 211679 413 79532286
Fracture nonunion 12.93 9.47 18 211671 1504 79531195
Sarcoidosis 12.89 9.47 50 211639 8285 79524414
Immune thrombocytopenia 12.88 9.47 17 211672 17788 79514911
Female genital tract fistula 12.86 9.47 40 211649 5935 79526764
Stevens-Johnson syndrome 12.72 9.47 57 211632 39109 79493590
Large intestine polyp 12.71 9.47 67 211622 12641 79520058
Bronchopulmonary aspergillosis 12.64 9.47 25 211664 22269 79510430
Oropharyngeal pain 12.64 9.47 209 211480 109144 79423555
Post procedural diarrhoea 12.63 9.47 12 211677 662 79532037
Erythema multiforme 12.62 9.47 17 211672 17634 79515065
Peripheral pulse decreased 12.56 9.47 5 211684 53 79532646
Creatinine renal clearance decreased 12.55 9.47 90 211599 18912 79513787
Hypermagnesaemia 12.55 9.47 16 211673 1228 79531471
Rhinovirus infection 12.54 9.47 48 211641 7905 79524794
Product monitoring error 12.54 9.47 4 211685 8902 79523797
Blood potassium decreased 12.49 9.47 183 211506 46329 79486370
Immune reconstitution inflammatory syndrome 12.48 9.47 11 211678 13830 79518869
Congenital knee deformity 12.46 9.47 4 211685 21 79532678
Grip strength decreased 12.44 9.47 100 211589 21769 79510930
Behavioural addiction 12.39 9.47 5 211684 55 79532644
Hypomagnesaemia 12.37 9.47 184 211505 46727 79485972
Oxygen saturation decreased 12.31 9.47 255 211434 128792 79403907
Lymphoma 12.30 9.47 17 211672 17443 79515256
Impaired quality of life 12.30 9.47 12 211677 14374 79518325
Medication error 12.26 9.47 253 211436 68389 79464310
Fungal infection 12.25 9.47 63 211626 41685 79491014
Osteoarthritis 12.23 9.47 311 211378 86998 79445701
Poliomyelitis 12.23 9.47 5 211684 57 79532642
Hyperphosphataemia 12.20 9.47 41 211648 6335 79526364
Wall motion score index abnormal 12.20 9.47 7 211682 175 79532524
Central nervous system mass 12.16 9.47 7 211682 176 79532523
Atypical fracture 12.16 9.47 12 211677 694 79532005
Product substitution issue 12.11 9.47 22 211667 20234 79512465
Visceral oedema 12.08 9.47 6 211683 111 79532588
Blood bicarbonate increased 12.07 9.47 16 211673 1276 79531423
Contraindicated product administered 12.05 9.47 322 211367 157216 79375483
Autoimmune colitis 12.05 9.47 18 211671 1605 79531094
Ketoacidosis 12.03 9.47 3 211686 7851 79524848
Obstruction 11.97 9.47 33 211656 4577 79528122
Femur fracture 11.97 9.47 156 211533 38496 79494203
Blood calcium increased 11.93 9.47 57 211632 10343 79522356
Agitation 11.93 9.47 348 211341 99367 79433332
Compartment syndrome 11.86 9.47 35 211654 5047 79527652
Spinal cord injury lumbar 11.72 9.47 5 211684 64 79532635
Substance-induced mood disorder 11.70 9.47 6 211683 119 79532580
Bilirubin conjugated abnormal 11.66 9.47 6 211683 120 79532579
Gynaecomastia 11.64 9.47 3 211686 7678 79525021
Skin ulcer 11.61 9.47 90 211599 54060 79478639
Candida infection 11.59 9.47 57 211632 38157 79494542
Mucormycosis 11.58 9.47 4 211685 8465 79524234
Cardiac disorder 11.57 9.47 115 211574 65642 79467057
Pathological fracture 11.55 9.47 57 211632 10480 79522219
Haematoma 11.55 9.47 86 211603 52109 79480590
Obstructive airways disorder 11.50 9.47 131 211558 31328 79501371
Psychiatric disorder prophylaxis 11.45 9.47 5 211684 68 79532631
Sinusitis 11.44 9.47 414 211275 195087 79337612
Induced abortion failed 11.39 9.47 7 211682 199 79532500
Radiculopathy 11.34 9.47 50 211639 8774 79523925
SARS-CoV-2 test negative 11.33 9.47 16 211673 1355 79531344
Cirrhosis alcoholic 11.29 9.47 14 211675 1045 79531654
Respiratory tract infection bacterial 11.28 9.47 20 211669 2057 79530642
Oncocytoma 11.26 9.47 4 211685 30 79532669
Skin toxicity 11.24 9.47 4 211685 8310 79524389
Respiratory tract congestion 11.22 9.47 91 211598 19863 79512836
Shunt infection 11.21 9.47 7 211682 205 79532494
Respiratory symptom 11.18 9.47 33 211656 4758 79527941
Fear of injection 11.17 9.47 3 211686 7471 79525228
Dislocation of vertebra 11.17 9.47 46 211643 7834 79524865
Acquired haemophilia 11.16 9.47 19 211670 1892 79530807
Pharyngitis 11.11 9.47 27 211662 22348 79510351
Urticaria 11.11 9.47 391 211298 184810 79347889
Illness 11.09 9.47 75 211614 46436 79486263
Hot flush 11.06 9.47 206 211483 54671 79478028
Conjunctival scar 11.06 9.47 7 211682 210 79532489
Eye disorder 11.05 9.47 29 211660 23383 79509316
Neuropathy peripheral 11.02 9.47 288 211401 141017 79391682
Calcification metastatic 11.02 9.47 6 211683 135 79532564
Enterocolitis bacterial 10.98 9.47 11 211678 648 79532051
Drug abuser 10.92 9.47 38 211651 5975 79526724
Melaena 10.92 9.47 106 211583 60784 79471915
Cough 10.90 9.47 832 210857 365957 79166742
Device related infection 10.87 9.47 139 211550 34155 79498544
Bronchospasm 10.83 9.47 32 211657 24827 79507872
Sinus disorder 10.82 9.47 99 211590 22365 79510334
Death neonatal 10.75 9.47 11 211678 664 79532035
Drug screen positive 10.74 9.47 38 211651 6025 79526674
Hypercholesterolaemia 10.73 9.47 101 211588 22994 79509705
Necrotising ulcerative gingivostomatitis 10.72 9.47 4 211685 35 79532664
Foetal death 10.66 9.47 4 211685 8040 79524659
Posterior reversible encephalopathy syndrome 10.63 9.47 35 211654 26246 79506453
Cytomegalovirus viraemia 10.61 9.47 11 211678 12810 79519889
Acute myeloid leukaemia 10.61 9.47 44 211645 30841 79501858
SARS-CoV-2 antibody test positive 10.56 9.47 9 211680 430 79532269
Gastrointestinal toxicity 10.46 9.47 46 211643 8063 79524636
Pulmonary calcification 10.44 9.47 9 211680 437 79532262
Flushing 10.43 9.47 168 211521 88100 79444599
Osteomalacia 10.40 9.47 16 211673 1464 79531235
Penile erythema 10.38 9.47 6 211683 152 79532547
Anaemia 10.33 9.47 1029 210660 443986 79088713
Hip fracture 10.31 9.47 126 211563 30635 79502064
Tinnitus 10.31 9.47 72 211617 44261 79488438
Vaginal haemorrhage 10.31 9.47 27 211662 21790 79510909
Neutropenic sepsis 10.29 9.47 37 211652 27027 79505672
Fracture 10.29 9.47 27 211662 21774 79510925
Dyskinesia 10.28 9.47 73 211616 44700 79487999
Device dislocation 10.22 9.47 35 211654 25935 79506764
Gastrointestinal stoma complication 10.19 9.47 22 211667 2615 79530084
Anaphylactic shock 10.18 9.47 55 211634 35941 79496758
Caesarean section 10.10 9.47 11 211678 12524 79520175
Anti-saccharomyces cerevisiae antibody test positive 10.08 9.47 4 211685 42 79532657
Gastritis alcoholic 10.00 9.47 4 211685 43 79532656
Noninfectious peritonitis 9.98 9.47 7 211682 250 79532449
Fracture pain 9.96 9.47 11 211678 725 79531974
Red blood cell count decreased 9.95 9.47 211 211478 57302 79475397
Myocardial fibrosis 9.93 9.47 17 211672 1701 79530998
Arthropathy 9.93 9.47 377 211312 176734 79355965
No adverse event 9.88 9.47 58 211631 37134 79495565
Lymphadenopathy 9.85 9.47 92 211597 53155 79479544
Tibia fracture 9.84 9.47 34 211655 5327 79527372
Accident 9.84 9.47 48 211641 8783 79523916
Acute graft versus host disease in skin 9.83 9.47 4 211685 7654 79525045
Fungal cystitis 9.82 9.47 3 211686 13 79532686
Transient ischaemic attack 9.76 9.47 91 211598 52604 79480095
Live birth 9.75 9.47 84 211605 18660 79514039
Renal failure 9.73 9.47 435 211254 200533 79332166
Ischaemic stroke 9.72 9.47 50 211639 33081 79499618
Electrolyte imbalance 9.72 9.47 125 211564 30756 79501943
Alcoholic 9.60 9.47 4 211685 48 79532651
Benzodiazepine drug level therapeutic 9.60 9.47 4 211685 48 79532651
Hypertensive crisis 9.59 9.47 26 211663 20744 79511955
Chest pain 9.58 9.47 633 211056 281671 79251028
Injection site extravasation 9.57 9.47 7 211682 9662 79523037
Abscess intestinal 9.57 9.47 22 211667 2729 79529970
Guillain-Barre syndrome 9.53 9.47 6 211683 8959 79523740
Carcinoid tumour of the small bowel 9.51 9.47 7 211682 270 79532429
Irritability 9.48 9.47 67 211622 41077 79491622

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P03AX05 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES
Other ectoparasiticides, incl. scabicides
FDA PE N0000010282 Skin Barrier Activity
MeSH PA D000934 Antifoaming Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004643 Emollients
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:63047 food emulsifiers
CHEBI has role CHEBI:77965 food anti-caking agent
CHEBI has role CHEBI:78058 food antifoaming agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diaper rash indication 91487003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018922 VUID
N0000147215 NUI
D01540 KEGG_DRUG
4018922 VANDF
4019331 VANDF
C1113707 UMLSCUI
CHEBI:31498 CHEBI
CHEMBL2108200 ChEMBL_ID
DB11074 DRUGBANK_ID
CHEMBL4297192 ChEMBL_ID
CHEMBL1200838 ChEMBL_ID
C501844 MESH_SUPPLEMENTAL_RECORD_UI
C013830 MESH_SUPPLEMENTAL_RECORD_UI
2898 INN_ID
92RU3N3Y1O UNII
DB09512 DRUGBANK_ID
DB14005 DRUGBANK_ID
1299921 RXNORM
4607 MMSL
5175 MMSL
5464 MMSL
d01027 MMSL
001144 NDDF
001915 NDDF
387442005 SNOMEDCT_US
396031000 SNOMEDCT_US
420874002 SNOMEDCT_US
77898008 SNOMEDCT_US
D012841 MESH_DESCRIPTOR_UI
6433516 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gas-XExtra Strength HUMAN OTC DRUG LABEL 1 0067-0117 TABLET, CHEWABLE 125 mg ORAL OTC monograph final 10 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0118 TABLET, CHEWABLE 250 mg ORAL OTC monograph final 14 sections
Gas-XTotal Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0119 TABLET, CHEWABLE 250 mg ORAL OTC monograph final 14 sections
Gas-XExtra Strength HUMAN OTC DRUG LABEL 1 0067-0129 TABLET, CHEWABLE 125 mg ORAL OTC monograph final 10 sections
Gas-XUltra Strength AntiGas Softgels HUMAN OTC DRUG LABEL 1 0067-6274 CAPSULE, LIQUID FILLED 180 mg ORAL OTC monograph final 10 sections
Gas-XExtra Strength Softgels HUMAN OTC DRUG LABEL 1 0067-6275 CAPSULE, LIQUID FILLED 125 mg ORAL OTC monograph final 11 sections
Gas-XExtra Strength Softgels HUMAN OTC DRUG LABEL 1 0067-6275 CAPSULE, LIQUID FILLED 125 mg ORAL OTC monograph final 11 sections
Gas-XMaximum Strength Softgels HUMAN OTC DRUG LABEL 1 0067-6283 CAPSULE, LIQUID FILLED 250 mg ORAL OTC monograph final 10 sections
Moisturel HUMAN OTC DRUG LABEL 1 0093-3204 LOTION 30 g TOPICAL OTC monograph final 13 sections
good sense anti diarrheal anti gas HUMAN OTC DRUG LABEL 2 0113-0087 TABLET 125 mg ORAL ANDA 16 sections
Good Sense antacid HUMAN OTC DRUG LABEL 3 0113-0340 SUSPENSION 80 mg ORAL OTC monograph final 13 sections
Good Sense AntacidRegular Strength HUMAN OTC DRUG LABEL 3 0113-0357 SUSPENSION 40 mg ORAL OTC monograph final 13 sections
Good Sense Gas ReliefExtra Strength HUMAN OTC DRUG LABEL 1 0113-0428 CAPSULE, LIQUID FILLED 125 mg ORAL OTC monograph final 10 sections
Good Sense AntacidMaximum Strength HUMAN OTC DRUG LABEL 3 0113-0588 SUSPENSION 80 mg ORAL OTC monograph final 13 sections
good sense gas relief HUMAN OTC DRUG LABEL 1 0113-0657 CAPSULE, LIQUID FILLED 180 mg ORAL OTC monograph final 11 sections
good sense antacid HUMAN OTC DRUG LABEL 3 0113-0851 SUSPENSION 40 mg ORAL OTC monograph final 13 sections
good sense simethiconeinfants HUMAN OTC DRUG LABEL 1 0113-0882 EMULSION 20 mg ORAL OTC monograph final 11 sections
Good Sense Anti Diarrheal Anti Gas HUMAN OTC DRUG LABEL 2 0113-1087 TABLET 125 mg ORAL ANDA 16 sections
injoy gas relief HUMAN OTC DRUG LABEL 1 0113-6011 CAPSULE, LIQUID FILLED 125 mg ORAL OTC monograph final 10 sections
basic care loperamide hydrochloride and simethicone HUMAN OTC DRUG LABEL 2 0113-7119 TABLET 125 mg ORAL ANDA 16 sections
Mag-AL Plus HUMAN OTC DRUG LABEL 3 0121-1761 SUSPENSION 20 mg ORAL OTC monograph final 14 sections
Mag-AL Plus HUMAN OTC DRUG LABEL 3 0121-1761 SUSPENSION 20 mg ORAL OTC monograph final 14 sections
Mag-AL Plus HUMAN OTC DRUG LABEL 3 0121-1761 SUSPENSION 20 mg ORAL OTC monograph final 14 sections
Mag-AL PlusXS HUMAN OTC DRUG LABEL 3 0121-1762 SUSPENSION 40 mg ORAL OTC monograph final 15 sections
Mag-AL PlusXS HUMAN OTC DRUG LABEL 3 0121-1762 SUSPENSION 40 mg ORAL OTC monograph final 15 sections
PHAZYME HUMAN OTC DRUG LABEL 1 0132-0208 CAPSULE, GELATIN COATED 180 mg ORAL OTC MONOGRAPH FINAL 12 sections
PHAZYME HUMAN OTC DRUG LABEL 1 0132-0210 CAPSULE, GELATIN COATED 180 mg ORAL export only 10 sections
PHAZYME HUMAN OTC DRUG LABEL 1 0132-0211 CAPSULE, GELATIN COATED 250 mg ORAL OTC MONOGRAPH FINAL 12 sections
PHAZYME HUMAN OTC DRUG LABEL 1 0132-0211 CAPSULE, GELATIN COATED 250 mg ORAL OTC MONOGRAPH FINAL 12 sections
PHAZYME HUMAN OTC DRUG LABEL 1 0132-0214 CAPSULE, GELATIN COATED 250 mg ORAL OTC MONOGRAPH FINAL 11 sections