dimercaprol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3150 | 59-52-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 6, 1946 | FDA | AKORN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V03AB09 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes |
| FDA MoA | N0000175472 | Metal Chelating Activity |
| FDA EPC | N0000175473 | Metal Chelator |
| MeSH PA | D002614 | Chelating Agents |
| MeSH PA | D064449 | Sequestering Agents |
| CHEBI has role | CHEBI:38161 | Chelating agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Toxic effect of arsenic AND/OR its compounds | indication | 81844008 | |
| Accidental poisoning by lead and its compounds and fumes | indication | 216777009 | |
| Gold Toxicity | indication | ||
| Mercury Toxicity | indication | ||
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Poisoning by iron AND/OR its compounds | contraindication | 55381001 | |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Cadmium Toxicity | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.91 | acidic |
| pKa2 | 11.55 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018102 | VUID |
| N0000146440 | NUI |
| D00167 | KEGG_DRUG |
| 4018102 | VANDF |
| C0012383 | UMLSCUI |
| CHEBI:64198 | CHEBI |
| CHEMBL1597 | ChEMBL_ID |
| 3080 | PUBCHEM_CID |
| DB06782 | DRUGBANK_ID |
| D004112 | MESH_DESCRIPTOR_UI |
| 1614 | INN_ID |
| 0CPP32S55X | UNII |
| 3445 | RXNORM |
| 4606 | MMSL |
| d01401 | MMSL |
| 001087 | NDDF |
| 13664004 | SNOMEDCT_US |
| 387077001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| BAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-526 | INJECTION | 100 mg | INTRAMUSCULAR | NDA | 16 sections |
| BAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-526 | INJECTION | 100 mg | INTRAMUSCULAR | NDA | 16 sections |