benserazide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
314 322-35-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benserazide hydrochloride
  • benserazide
  • serazide
  • benserazide HCl
An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
  • Molecular weight: 257.25
  • Formula: C10H15N3O5
  • CLOGP: -2.90
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 7
  • TPSA: 148.07
  • ALOGS: -1.70
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.10 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
S (Water solubility) 10 mg/mL Bocci G, Oprea TI, Benet LZ
fu (Fraction unbound in plasma) 0.73 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1990 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 65.29 57.15 31 387 229100 63259504

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product prescribing error 53.10 44.55 18 620 44795 79698955
General physical health deterioration 51.17 44.55 30 608 275208 79468542
Drug interaction 49.16 44.55 34 604 415149 79328601
Delirium 45.30 44.55 19 619 84608 79659142

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:48407 antiparkinson agent
CHEBI has role CHEBI:48560 dopaminergic agents
CHEBI has role CHEBI:59321 aromatic-L-amino-acid decarboxylase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.67 acidic
pKa2 11.55 acidic
pKa3 12.19 acidic
pKa4 13.97 acidic
pKa5 6.88 Basic
pKa6 3.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aromatic-L-amino-acid decarboxylase Enzyme WOMBAT-PK
Estrogen receptor beta Nuclear hormone receptor IC50 5.52 CHEMBL
SUMO-activating enzyme Enzyme IC50 4.63 CHEMBL
Hexokinase-2 Kinase IC50 5.26 CHEMBL
Zinc finger protein mex-5 Cytosolic other EC50 6.95 CHEMBL
Cytoplasmic zinc-finger protein Unclassified EC50 4.43 CHEMBL
Genome polyprotein [Cleaved into: P1; Capsid protein VP0 Unclassified IC50 5.62 CHEMBL

External reference:

IDSource
D01653 KEGG_DRUG
14919-77-8 SECONDARY_CAS_RN
1374 RXNORM
C0005014 UMLSCUI
CHEBI:64187 CHEBI
CHEMBL1096979 ChEMBL_ID
CHEMBL1255778 ChEMBL_ID
DB12783 DRUGBANK_ID
D001545 MESH_DESCRIPTOR_UI
2327 PUBCHEM_CID
5150 IUPHAR_LIGAND_ID
3026 INN_ID
762OS3ZEJU UNII
391821005 SNOMEDCT_US
391822003 SNOMEDCT_US
420240007 SNOMEDCT_US
003682 NDDF
003683 NDDF

Pharmaceutical products:

None