diphenidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	313	972-02-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cephadol
difenidol
diphenadol
lansenol
diphenidol hydrochloride
diphenidol
difenidol hydrochloride
difenidol embonate
diphenidol HCl
difenidol HCl

shows anti-arrhythmic activity; RN given refers to unlabeled parent cpd

Molecular weight: 309.45
Formula: C21H27NO
CLOGP: 4.07
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 23.47
ALOGS: -4.72
ROTB: 6

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
April 5, 1967	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA PE	N0000009034	Emesis Suppression
MeSH PA	D000932	Antiemetics
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D018373	Peripheral Nervous System Agents
CHEBI has role	CHEBI:50919	antiemetico
FDA EPC	N0000178372	Antiemetic

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vertigo	indication	399153001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.28	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	ANTAGONIST	Ki	7.11		DRUG MATRIX	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.97		DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.13		DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.11		DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	6.56		DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	7.28		DRUG MATRIX
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	7.42		DRUG MATRIX
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	6.07		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.49		DRUG MATRIX
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	5.96		DRUG MATRIX
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.47		CHEMBL
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	5.58		DRUG MATRIX

External reference:

ID	Source
D01318	KEGG_DRUG
3254-89-5	SECONDARY_CAS_RN
23370	RXNORM
CHEBI:4638	CHEBI
CHEMBL936	ChEMBL_ID
C004858	MESH_SUPPLEMENTAL_RECORD_UI
7163	IUPHAR_LIGAND_ID
1433	INN_ID
DB01231	DRUGBANK_ID
NQO8R319LY	UNII
32030002	SNOMEDCT_US
63779001	SNOMEDCT_US
767579009	SNOMEDCT_US
C0058371	UMLSCUI
CHEMBL1529	ChEMBL_ID
4018019	VANDF
4019725	VANDF
3055	PUBCHEM_CID
001681	NDDF
001682	NDDF

Pharmaceutical products:

None