cloxiquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quinoline derivatives	3114	130-16-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cloxyquin
5-Chlorooxine
8-Hydroxy-5-chloroquinoline
cloxiquine
dermofongin
dermofungin

has antitubercular activity

Molecular weight: 179.60
Formula: C9H6ClNO
CLOGP: 2.91
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 33.12
ALOGS: -2.33
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.28	acidic
pKa2	3.74	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Methionine aminopeptidase 2	Enzyme	P50579	MAP2_HUMAN		IC50	5.90		CHEMBL
Methionine aminopeptidase 1	Enzyme	P53582	MAP11_HUMAN		IC50	4.89		CHEMBL
Catechol O-methyltransferase	Enzyme		COMT_RAT		IC50	4.63		CHEMBL

External reference:

ID	Source
D03572	KEGG_DRUG
CHEBI:134818	CHEBI
HZQ	PDB_CHEM_ID
CHEMBL225164	ChEMBL_ID
DB15933	DRUGBANK_ID
C519493	MESH_SUPPLEMENTAL_RECORD_UI
2817	PUBCHEM_CID
006732	NDDF
C0772059	UMLSCUI
3428	INN_ID
BPF36H1G6S	UNII

Pharmaceutical products:

None