citrulline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3103	372-75-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: citrulline L-Citrulline sigma-Ureidonorvaline	Molecular weight: 175.19 Formula: C6H13N3O3 CLOGP: -3.36 LIPINSKI: 0 HAC: 6 HDO: 4 TPSA: 118.44 ALOGS: -0.90 ROTB: 5

Molecule

Description

Molfile Inchi Smiles

Synonyms:

citrulline
L-Citrulline
sigma-Ureidonorvaline

Molecular weight: 175.19
Formula: C6H13N3O3
CLOGP: -3.36
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 118.44
ALOGS: -0.90
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperammonaemic crisis	74.98	38.17	7	90	32	63488893
Ammonia increased	41.51	38.17	7	90	4649	63484276
Hyperammonaemia	40.69	38.17	7	90	5225	63483700

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperammonaemic crisis	78.10	45.02	8	90	55	34956778

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperammonaemic crisis	125.18	40.51	13	228	94	79744053
Hyperammonaemia	53.01	40.51	11	230	11082	79733065
Ammonia increased	50.95	40.51	10	231	7625	79736522

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:50267	protective agents
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:61908	nitric oxide synthase inhibitors
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:59174	haptens
CHEBI has role	CHEBI:83056	Daphnia magna metabolites

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Hyperammonemia	off-label use	9360008
Arginase deficiency	off-label use	23501004	DOID:9278
Congenital hyperammonemia, type I	off-label use	62522004
Ornithine Carbamyltransferase Deficiency	off-label use	80908008	DOID:9271
Lysinuric protein intolerance	off-label use	303852004	DOID:0060439
Arginosuccinate Lyase Deficiency	off-label use

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🐶 Veterinary Drug Use

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🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.12	acidic
pKa2	11.32	acidic
pKa3	13.72	acidic
pKa4	9.52	Basic

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Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
CIR	PDB_CHEM_ID
004479	NDDF
175680	MMSL
22711	MMSL
2567	RXNORM
29VT07BGDA	UNII
30022007	SNOMEDCT_US
4025081	VUID
4025081	VANDF
441997001	SNOMEDCT_US

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections

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