citrulline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3103 372-75-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • citrulline
  • L-Citrulline
  • sigma-Ureidonorvaline
  • Molecular weight: 175.19
  • Formula: C6H13N3O3
  • CLOGP: -3.36
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 118.44
  • ALOGS: -0.90
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperammonaemic crisis 74.53 46.95 7 76 32 50605009

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperammonaemic crisis 78.33 46.24 8 83 48 29574388

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperammonaemic crisis 124.77 44.46 13 205 86 64498428
Hyperammonaemia 53.06 44.46 11 207 9893 64488621
Ammonia increased 50.75 44.46 10 208 6967 64491547

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:61908 nitric oxide synthase inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:59174 haptens
CHEBI has role CHEBI:83056 Daphnia magna metabolites
CHEBI has role CHEBI:76924 plant metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hyperammonemia off-label use 9360008
Arginase deficiency off-label use 23501004 DOID:9278
Congenital hyperammonemia, type I off-label use 62522004
Lysinuric protein intolerance off-label use 303852004 DOID:0060439
Ornithine Carbamyltransferase Deficiency off-label use
Arginosuccinate Lyase Deficiency off-label use




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.12 acidic
pKa2 11.32 acidic
pKa3 13.72 acidic
pKa4 9.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4025081 VUID
N0000171745 NUI
D07706 KEGG_DRUG
4025081 VANDF
C0008864 UMLSCUI
CHEBI:18211 CHEBI
CIR PDB_CHEM_ID
CHEMBL444814 ChEMBL_ID
DB00155 DRUGBANK_ID
D002956 MESH_DESCRIPTOR_UI
9750 PUBCHEM_CID
722 IUPHAR_LIGAND_ID
29VT07BGDA UNII
2567 RXNORM
175680 MMSL
22711 MMSL
NOCODE MMSL
d06051 MMSL
004479 NDDF
30022007 SNOMEDCT_US
441997001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections