citrulline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3103	372-75-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

citrulline
L-Citrulline
sigma-Ureidonorvaline

Molecular weight: 175.19
Formula: C6H13N3O3
CLOGP: -3.36
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 118.44
ALOGS: -0.90
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperammonaemic crisis	74.98	38.17	7	90	32	63488893
Ammonia increased	41.51	38.17	7	90	4649	63484276
Hyperammonaemia	40.69	38.17	7	90	5225	63483700

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperammonaemic crisis	78.10	45.02	8	90	55	34956778

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperammonaemic crisis	125.18	40.51	13	228	94	79744053
Hyperammonaemia	53.01	40.51	11	230	11082	79733065
Ammonia increased	50.95	40.51	10	231	7625	79736522

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:50267	protective agents
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:61908	nitric oxide synthase inhibitors
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:59174	haptens
CHEBI has role	CHEBI:83056	Daphnia magna metabolites
CHEBI has role	CHEBI:76924	plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hyperammonemia	off-label use	9360008
Arginase deficiency	off-label use	23501004	DOID:9278
Congenital hyperammonemia, type I	off-label use	62522004
Ornithine Carbamyltransferase Deficiency	off-label use	80908008	DOID:9271
Lysinuric protein intolerance	off-label use	303852004	DOID:0060439
Arginosuccinate Lyase Deficiency	off-label use

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.12	acidic
pKa2	11.32	acidic
pKa3	13.72	acidic
pKa4	9.52	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4025081	VUID
N0000171745	NUI
D07706	KEGG_DRUG
4025081	VANDF
C0008864	UMLSCUI
CHEBI:18211	CHEBI
CIR	PDB_CHEM_ID
CHEMBL444814	ChEMBL_ID
DB00155	DRUGBANK_ID
D002956	MESH_DESCRIPTOR_UI
9750	PUBCHEM_CID
722	IUPHAR_LIGAND_ID
29VT07BGDA	UNII
2567	RXNORM
175680	MMSL
22711	MMSL
NOCODE	MMSL
d06051	MMSL
004479	NDDF
30022007	SNOMEDCT_US
441997001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections