cinchophen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quinoline derivatives	3101	132-60-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phenylcinchoninic acid
cincain
cinchophen
aciphenochinoline
aciphenochinolinium
cinchophene
cinchophenic acid
cinconal
cincophen
phenoquin
quinofen
quinophan
quinophen

Molecular weight: 249.27
Formula: C16H11NO2
CLOGP: 4.28
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 50.19
ALOGS: -3.85
ROTB: 2

Drug dosage:

Dose	Unit	Route
1	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Hosey CM, Chan R, Benet LZ
S (Water solubility)	0.16 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M04AC02	MUSCULO-SKELETAL SYSTEM ANTIGOUT PREPARATIONS ANTIGOUT PREPARATIONS Preparations with no effect on uric acid metabolism
MeSH PA	D000777	Anesthetics
MeSH PA	D000779	Anesthetics, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Gout	indication	90560007	DOID:13189

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.35	acidic
pKa2	4.7	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Enzyme	Q9Y233	PDE10_HUMAN		Kd	3.90		CHEMBL

External reference:

ID	Source
D07280	KEGG_DRUG
C0008793	UMLSCUI
CHEBI:114195	CHEBI
CHEMBL348000	ChEMBL_ID
DB13551	DRUGBANK_ID
C084834	MESH_SUPPLEMENTAL_RECORD_UI
8593	PUBCHEM_CID
1332	INN_ID
39Y533Z02M	UNII
61709008	SNOMEDCT_US
D003992	MESH_DESCRIPTOR_UI

Pharmaceutical products:

None