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cholic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3096 | 81-25-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.623 | Moderate | 0.75 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 4.036 | Moderate | 0.75 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 16.943 | 10^-6 cm/s | Moderate | 0.75 |
| dh-clint | Dog hepatocyte intrinsic clearance | 7.295 | uL/min/10^6 cells | Moderate | 0.75 |
| dppb | Dog plasma protein binding (% unbound) | 10.690 | % | Moderate | 0.75 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 20.410 | % | Moderate | 0.75 |
| herg | hERG pIC50 | 4.638 | pIC50 | Moderate | 0.75 |
| hh-clint | Human hepatocyte intrinsic clearance | 2.427 | uL/min/10^6 cells | Moderate | 0.75 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.475 | uL/min/mg protein | Moderate | 0.75 |
| hppb | Human plasma protein binding (% unbound) | 13.220 | % | Moderate | 0.75 |
| kinase-safety-class | ACVR2B,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK | 15 | |||
| kinase-selectivity-class | EIF2AK3,MAP2K6 | 2 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 4.477 | Moderate | 0.75 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 15.885 | Moderate | 0.75 | |
| mppb | Mouse plasma protein binding (% unbound) | 14.070 | Moderate | 0.75 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 4.775 | Moderate | 0.75 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 6.420 | % | Moderate | 0.75 |
| rh-clint | Rat hepatocyte intrinsic clearance | 24.660 | uL/min/10^6 cells | Moderate | 0.75 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 64.540 | % | Moderate | 0.75 |
| rppb | Rat plasma protein binding (% unbound) | 15.940 | % | Moderate | 0.75 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 935.406 | uM | Moderate | 0.75 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 17, 2015 | FDA | RTRX | |
| Sept. 12, 2013 | EMA | Laboratoires CTRS | |
| March 27, 2023 | PMDA | ReqMed Company, Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A05AA03 | ALIMENTARY TRACT AND METABOLISM BILE AND LIVER THERAPY BILE THERAPY Bile acids and derivatives |
| FDA CS | M0002475 | Bile Acids and Salts |
| FDA EPC | N0000175802 | Bile Acid |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:77746 | human metabolite |
Related Drugs by ATC class:
A05AA Bile acids and derivatives 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Constipation | indication | 14760008 | DOID:2089 |
| Cholestanol storage disease | indication | 63246000 | DOID:4810 |
| Disorder of biliary tract | indication | 105997008 | DOID:9741 |
| 3-Beta-hydroxy-delta-5-C27-steroid dehydrogenase deficiency | indication | 238033007 | |
| Delta-4-3-oxosteroid-5-beta-reductase deficiency | indication | 238035000 | |
| Incomplete passage of stool | indication | 249515001 | |
| Calculus in biliary tract | indication | 266474003 | |
| Inborn error of bile acid metabolism | indication | ||
| Hypercholesterolemia | contraindication | 13644009 | |
| Obstruction of bile duct | contraindication | 30144000 | |
| Primary biliary cirrhosis | contraindication | 31712002 | DOID:12236 |
| Diarrhea | contraindication | 62315008 | |
| Incontinence of feces | contraindication | 72042002 | |
| Appendicitis | contraindication | 74400008 | DOID:8337 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Sclerosing cholangitis | contraindication | 235917005 | DOID:14268 |
| Pregnancy, function | contraindication | 289908002 | |
| Gallstone Complications | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.92 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bile acid receptor | Nuclear hormone receptor | EC50 | 4.35 | CHEMBL | |||||
| G-protein coupled bile acid receptor 1 | GPCR | AGONIST | EC50 | 5 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| 4034356 | VUID |
| N0000191551 | NUI |
| 4034356 | VANDF |
| C0055568 | UMLSCUI |
| CHEBI:16359 | CHEBI |
| CHD | PDB_CHEM_ID |
| CHEMBL205596 | ChEMBL_ID |
| D019826 | MESH_DESCRIPTOR_UI |
| DB02659 | DRUGBANK_ID |
| 221493 | PUBCHEM_CID |
| 609 | IUPHAR_LIGAND_ID |
| G1JO7801AE | UNII |
| 1440856 | RXNORM |
| 233415 | MMSL |
| 27024 | MMSL |
| d07574 | MMSL |
| 007568 | NDDF |
| 17147002 | SNOMEDCT_US |
| 781369008 | SNOMEDCT_US |
| G1JO7801AE | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| CHOLBAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 79378-001 | CAPSULE | 50 mg | ORAL | NDA | 25 sections |
| CHOLBAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 79378-002 | CAPSULE | 250 mg | ORAL | NDA | 25 sections |