chloroxylenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3094	88-04-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: chloroxylenol sodium chloroxylenol benzytol parametaxylenol	a antiseptic halogenated phenol, non-toxic, non-corrosive, non-staining with high phenol coefficient, it may be applied directly to a wound and shows no chemical reactivity toward blood Molecular weight: 156.61 Formula: C8H9ClO CLOGP: 3.48 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -2.26 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chloroxylenol sodium
chloroxylenol
benzytol
parametaxylenol

a antiseptic halogenated phenol, non-toxic, non-corrosive, non-staining with high phenol coefficient, it may be applied directly to a wound and shows no chemical reactivity toward blood

Molecular weight: 156.61
Formula: C8H9ClO
CLOGP: 3.48
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -2.26
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	5943.82	30.20	1976	14388	131857	56143846
Toxicity to various agents	3569.64	30.20	1573	14791	222991	56052712
Drug abuse	1853.07	30.20	705	15659	66905	56208798
Intentional overdose	1253.31	30.20	534	15830	67583	56208120
Cardio-respiratory arrest	1203.77	30.20	489	15875	54832	56220871
Overdose	912.02	30.20	493	15871	105337	56170366
Suicide attempt	751.15	30.20	356	16008	57480	56218223
Alcohol interaction	528.23	30.20	125	16239	2208	56273495
Suspected suicide	453.51	30.20	132	16232	5334	56270369
Intentional product misuse	342.28	30.20	203	16161	51301	56224402
Respiratory arrest	335.20	30.20	168	16196	30457	56245246
Cardiac arrest	299.30	30.20	227	16137	86087	56189616
Alcohol poisoning	272.07	30.20	70	16294	1765	56273938
Death	262.40	30.20	402	15962	341024	55934679
Alcohol use	241.49	30.20	65	16299	1960	56273743
Coma	213.50	30.20	160	16204	59495	56216208
Somnolence	200.67	30.20	242	16122	163171	56112532
Drug ineffective	192.08	30.20	22	16342	918967	55356736
Alcohol abuse	187.26	30.20	53	16311	1931	56273772
Exposure to toxic agent	147.26	30.20	51	16313	3627	56272076
Poisoning deliberate	121.88	30.20	59	16305	9894	56265809
Loss of consciousness	121.24	30.20	154	16210	109195	56166508
Pain	113.56	30.20	27	16337	663157	55612546
Substance abuse	108.31	30.20	43	16321	4482	56271221
Agitation	107.19	30.20	105	16259	55931	56219772
Diarrhoea	101.69	30.20	30	16334	638477	55637226
Mydriasis	98.77	30.20	53	16311	11018	56264685
Rheumatoid arthritis	97.74	30.20	3	16361	382601	55893102
Alcoholism	97.68	30.20	33	16331	2176	56273527
Arthralgia	94.99	30.20	16	16348	501653	55774050
Blood alcohol increased	94.54	30.20	24	16340	572	56275131
Intentional self-injury	93.70	30.20	69	16295	24923	56250780
Poisoning	91.53	30.20	53	16311	12760	56262943
Fatigue	87.02	30.20	62	16302	788490	55487213
Rash	86.41	30.20	19	16345	493028	55782675
Postmortem blood drug level abnormal	85.23	30.20	20	16344	339	56275364
Seizure	77.41	30.20	134	16230	124985	56150718
Drug dependence	77.32	30.20	59	16305	22474	56253229
Suicidal ideation	74.74	30.20	88	16276	57654	56218049
Drug use disorder	73.69	30.20	33	16331	4636	56271067
Myocarditis	69.61	30.20	39	16325	8819	56266884
Dyspnoea	67.35	30.20	45	16319	592532	55683171
Drug interaction	66.68	30.20	171	16193	209584	56066119
Aggression	65.53	30.20	53	16311	21953	56253750
Victim of sexual abuse	65.32	30.20	18	16346	593	56275110
Pruritus	64.72	30.20	8	16356	316615	55959088
Drug withdrawal syndrome	64.05	30.20	56	16308	25801	56249902
Alopecia	63.57	30.20	6	16358	293452	55982251
Abdominal discomfort	61.88	30.20	5	16359	277269	55998434
Headache	61.46	30.20	44	16320	559000	55716703
Depressed level of consciousness	58.58	30.20	77	16287	56356	56219347
Drug intolerance	58.47	30.20	5	16359	264813	56010890
Pain in extremity	57.28	30.20	9	16355	297422	55978281
Pneumonia	56.32	30.20	24	16340	407074	55868629
Condition aggravated	55.12	30.20	16	16348	344882	55930821
Off label use	54.58	30.20	49	16315	556131	55719572
Swelling	54.40	30.20	4	16360	239767	56035936
Hypersensitivity	53.56	30.20	6	16358	256402	56019301
Peripheral swelling	53.01	30.20	4	16360	234722	56040981
Pyrexia	48.59	30.20	31	16333	418742	55856961
Tachycardia	47.58	30.20	99	16265	105777	56169926
Electrocardiogram QT prolonged	46.90	30.20	68	16296	54520	56221183
Liver injury	46.39	30.20	59	16305	41789	56233914
Sopor	45.28	30.20	42	16322	20880	56254823
Somnambulism	44.36	30.20	24	16340	5068	56270635
Asphyxia	44.16	30.20	25	16339	5764	56269939
Metabolic acidosis	43.22	30.20	56	16308	40398	56235305
Product dose omission issue	42.23	30.20	5	16359	204748	56070955
Nasopharyngitis	41.82	30.20	7	16357	220952	56054751
Back pain	41.73	30.20	9	16355	237161	56038542
Systemic lupus erythematosus	40.85	30.20	3	16361	180075	56095628
Chemical submission	40.82	30.20	10	16354	205	56275498
Nausea	40.42	30.20	103	16261	764075	55511628
Sinusitis	40.31	30.20	5	16359	197576	56078127
Anaemia	39.89	30.20	14	16350	267497	56008206
Asthenia	38.92	30.20	26	16338	342947	55932756
Drug hypersensitivity	38.38	30.20	16	16348	275189	56000514
Electrocardiogram QRS complex prolonged	37.41	30.20	22	16342	5445	56270258
Urinary tract infection	36.87	30.20	12	16352	240501	56035202
Infection	36.45	30.20	7	16357	200199	56075504
Weight increased	36.03	30.20	11	16353	229692	56046011
Amnesia	35.91	30.20	55	16309	46267	56229436
Protein C increased	35.59	30.20	8	16356	111	56275592
Homicide	35.07	30.20	10	16354	374	56275329
Cough	34.84	30.20	16	16348	259945	56015758
Abnormal behaviour	33.27	30.20	35	16329	20237	56255466
Ventricular tachycardia	32.90	30.20	32	16332	16869	56258834
Sinus tachycardia	32.04	30.20	36	16328	22408	56253295
Substance dependence	31.30	30.20	8	16356	196	56275507
Electrocardiogram ST segment elevation	31.14	30.20	17	16347	3652	56272051
Constipation	31.08	30.20	10	16354	201933	56073770
Therapeutic product effect decreased	30.69	30.20	6	16358	169446	56106257
Road traffic accident	30.36	30.20	39	16325	27888	56247815

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	4705.90	29.62	1829	18156	85929	31591430
Completed suicide	3743.38	29.62	1573	18412	89941	31587418
Toxicity to various agents	3390.86	29.62	1815	18170	179672	31497687
Intentional overdose	841.97	29.62	443	19542	40946	31636413
Cardio-respiratory arrest	799.96	29.62	462	19523	51264	31626095
Overdose	641.11	29.62	484	19501	84180	31593179
Alcohol abuse	593.12	29.62	186	19799	4378	31672981
Intentional product misuse	546.44	29.62	324	19661	37627	31639732
Alcohol interaction	528.16	29.62	152	19833	2637	31674722
Suicide attempt	520.62	29.62	312	19673	36936	31640423
Suspected suicide	378.17	29.62	129	19856	3978	31673381
Alcohol poisoning	293.48	29.62	100	19885	3071	31674288
Substance abuse	291.72	29.62	124	19861	7034	31670325
Drug dependence	289.08	29.62	179	19806	22400	31654959
Aggression	202.38	29.62	176	19809	37115	31640244
Coma	201.06	29.62	183	19802	40967	31636392
Respiratory depression	188.08	29.62	116	19869	14394	31662965
Poisoning deliberate	187.82	29.62	92	19893	7252	31670107
Alcohol use	184.67	29.62	71	19914	3096	31674263
Respiratory arrest	184.45	29.62	144	19841	26113	31651246
Asphyxia	155.96	29.62	75	19910	5676	31671683
Exposure to toxic agent	140.03	29.62	55	19930	2540	31674819
Drug ineffective	125.00	29.62	47	19938	395526	31281833
Diarrhoea	123.39	29.62	35	19950	352374	31324985
Pneumonia	116.07	29.62	34	19951	335278	31342081
Blood alcohol increased	115.29	29.62	35	19950	734	31676625
Incorrect route of product administration	113.62	29.62	78	19907	11595	31665764
Cardiac arrest	113.29	29.62	202	19783	88860	31588499
Intentional product use issue	109.61	29.62	145	19840	49202	31628157
Anaemia	107.34	29.62	7	19978	213515	31463844
Pyrexia	101.16	29.62	33	19952	303807	31373552
Poisoning	90.79	29.62	65	19920	10326	31667033
Drug withdrawal syndrome	88.76	29.62	82	19903	18668	31658691
Suicidal ideation	88.67	29.62	112	19873	36294	31641065
Fatigue	87.07	29.62	52	19933	335154	31342205
Rash	87.05	29.62	12	19973	201474	31475885
Intentional self-injury	80.64	29.62	67	19918	13248	31664111
Dyspnoea	80.17	29.62	60	19925	343419	31333940
Alcohol withdrawal syndrome	76.83	29.62	30	19955	1363	31675996
Drug use disorder	76.05	29.62	41	19944	3942	31673417
Miosis	75.77	29.62	54	19931	8516	31668843
Death	74.40	29.62	433	19552	360136	31317223
Sopor	73.88	29.62	60	19925	11492	31665867
Mydriasis	71.46	29.62	47	19938	6505	31670854
Agitation	70.24	29.62	124	19861	54045	31623314
Neutropenia	69.31	29.62	5	19980	140359	31537000
Cough	65.99	29.62	5	19980	134809	31542550
Off label use	63.05	29.62	76	19909	347198	31330161
Substance use disorder	62.59	29.62	20	19965	499	31676860
Drug interaction	62.17	29.62	278	19707	208265	31469094
Sepsis	61.16	29.62	11	19974	151918	31525441
Depressed level of consciousness	60.21	29.62	96	19889	38505	31638854
Road traffic accident	57.73	29.62	61	19924	16320	31661039
Arthralgia	56.72	29.62	13	19972	151411	31525948
Amnesia	55.38	29.62	71	19914	23331	31654028
Alcoholism	53.99	29.62	31	19954	3368	31673991
Medication error	53.75	29.62	69	19916	22703	31654656
Drug screen positive	52.96	29.62	32	19953	3820	31673539
Accidental death	51.42	29.62	26	19959	2191	31675168
Tachycardia	50.64	29.62	133	19852	76074	31601285
Alcohol intolerance	50.23	29.62	16	19969	395	31676964
Constipation	49.84	29.62	9	19976	123982	31553377
Pain	49.74	29.62	28	19957	186731	31490628
Somnolence	49.11	29.62	156	19829	99289	31578070
Platelet count decreased	49.02	29.62	6	19979	110429	31566930
Pruritus	48.38	29.62	10	19975	125157	31552202
Pain in extremity	47.66	29.62	8	19977	116195	31561164
Condition aggravated	47.53	29.62	22	19963	163987	31513372
Loss of consciousness	47.38	29.62	131	19854	77224	31600135
Ex-drug abuser	45.90	29.62	12	19973	142	31677217
Haemoglobin decreased	43.54	29.62	9	19976	112666	31564693
Pancytopenia	43.39	29.62	3	19982	87313	31590046
Asthenia	43.06	29.62	47	19938	224708	31452651
Hepatic fibrosis	42.76	29.62	28	19957	3846	31673513
Nausea	42.67	29.62	81	19904	307866	31369493
Infection	40.18	29.62	3	19982	81928	31595431
Product dose omission issue	39.65	29.62	9	19976	105577	31571782
Decreased appetite	39.31	29.62	24	19961	153193	31524166
Withdrawal syndrome	38.41	29.62	42	19943	11675	31665684
Impaired driving ability	38.24	29.62	22	19963	2399	31674960
Metabolic acidosis	38.23	29.62	80	19905	39497	31637862
Drug abuser	37.91	29.62	26	19959	3854	31673505
Back pain	37.87	29.62	11	19974	109402	31567957
Dysarthria	37.29	29.62	70	19915	31947	31645412
Pulmonary oedema	36.25	29.62	84	19901	44418	31632941
Weight decreased	35.84	29.62	29	19956	159923	31517436
Oedema peripheral	34.59	29.62	13	19972	109826	31567533
Homicide	34.19	29.62	15	19970	917	31676442
General physical health deterioration	33.17	29.62	15	19970	113420	31563939
Foetal alcohol syndrome	32.40	29.62	9	19976	136	31677223
Peripheral swelling	31.86	29.62	3	19982	67862	31609497
Cerebrovascular accident	31.43	29.62	6	19979	79478	31597881
Cardiac failure congestive	31.37	29.62	6	19979	79381	31597978
Thrombocytopenia	30.59	29.62	27	19958	142720	31534639
Urinary tract infection	29.98	29.62	6	19979	76863	31600496

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	9047.52	26.33	3488	29026	223647	70672283
Toxicity to various agents	6704.26	26.33	3295	29219	378877	70517053
Drug abuse	6396.95	26.33	2420	30094	144836	70751094
Cardio-respiratory arrest	1954.74	26.33	941	31573	99736	70796194
Intentional overdose	1706.57	26.33	852	31662	97583	70798347
Overdose	1269.38	26.33	850	31664	168895	70727035
Alcohol interaction	882.38	26.33	237	32277	4416	70891514
Intentional product misuse	846.01	26.33	499	32015	79096	70816834
Suicide attempt	812.47	26.33	486	32028	79024	70816906
Suspected suicide	752.78	26.33	242	32272	8592	70887338
Alcohol abuse	604.45	26.33	180	32334	4927	70891003
Respiratory arrest	489.79	26.33	306	32208	53627	70842303
Alcohol poisoning	457.02	26.33	140	32374	4225	70891705
Death	388.45	26.33	772	31742	509289	70386641
Cardiac arrest	374.52	26.33	412	32102	159422	70736508
Coma	368.26	26.33	318	32196	91526	70804404
Alcohol use	346.52	26.33	115	32399	4512	70891418
Substance abuse	328.65	26.33	135	32379	9702	70886228
Drug dependence	326.75	26.33	207	32307	37114	70858816
Poisoning deliberate	292.37	26.33	147	32367	16913	70879017
Drug ineffective	277.53	26.33	49	32465	939703	69956227
Exposure to toxic agent	277.09	26.33	105	32409	6089	70889841
Diarrhoea	210.02	26.33	51	32463	783290	70112640
Aggression	208.83	26.33	175	32339	48271	70847659
Blood alcohol increased	184.41	26.33	52	32462	1165	70894765
Respiratory depression	169.51	26.33	118	32396	24713	70871217
Pain	166.29	26.33	42	32472	628774	70267156
Fatigue	165.90	26.33	86	32428	824233	70071697
Asphyxia	162.30	26.33	84	32430	10258	70885672
Arthralgia	157.72	26.33	22	32492	503368	70392562
Poisoning	155.58	26.33	108	32406	22514	70873416
Somnolence	155.55	26.33	320	32194	215286	70680644
Rash	151.58	26.33	26	32488	510536	70385394
Agitation	151.52	26.33	200	32314	93175	70802755
Pneumonia	144.37	26.33	47	32467	596185	70299745
Dyspnoea	143.85	26.33	88	32426	769972	70125958
Off label use	138.65	26.33	85	32429	742975	70152955
Intentional self-injury	137.74	26.33	115	32399	31535	70864395
Mydriasis	137.33	26.33	88	32426	16065	70879865
Drug use disorder	136.00	26.33	69	32445	8082	70887848
Pyrexia	134.84	26.33	55	32459	606897	70289033
Incorrect route of product administration	133.77	26.33	105	32409	26387	70869543
Anaemia	127.79	26.33	17	32497	403406	70492524
Loss of consciousness	116.81	26.33	235	32279	155481	70740449
Condition aggravated	110.14	26.33	30	32484	427605	70468325
Nausea	108.97	26.33	139	32375	851949	70043981
Pruritus	108.37	26.33	15	32499	345545	70550385
Pain in extremity	108.35	26.33	12	32502	328070	70567860
Depressed level of consciousness	103.18	26.33	161	32353	87270	70808660
Miosis	100.91	26.33	69	32445	14032	70881898
Intentional product use issue	100.64	26.33	190	32324	119952	70775978
Alcoholism	96.34	26.33	45	32469	4400	70891530
Suicidal ideation	96.18	26.33	138	32376	69458	70826472
Substance use disorder	94.34	26.33	27	32487	639	70895291
Headache	91.68	26.33	79	32435	580326	70315604
Postmortem blood drug level abnormal	90.54	26.33	26	32488	623	70895307
Drug interaction	90.47	26.33	380	32134	381061	70514869
Cough	89.23	26.33	20	32494	325357	70570573
Sopor	86.12	26.33	88	32426	31179	70864751
Peripheral swelling	85.24	26.33	6	32508	236557	70659373
Back pain	84.44	26.33	12	32502	271140	70624790
Drug intolerance	83.46	26.33	5	32509	225682	70670248
Neutropenia	83.39	26.33	10	32504	257146	70638784
Metabolic acidosis	80.97	26.33	132	32382	74214	70821716
Accidental death	79.89	26.33	38	32476	3870	70892060
Alcohol withdrawal syndrome	77.98	26.33	30	32484	1811	70894119
Infusion related reaction	77.45	26.33	3	32511	197531	70698399
Tachycardia	77.43	26.33	202	32312	158344	70737586
Nasopharyngitis	76.26	26.33	7	32507	222199	70673731
Constipation	74.46	26.33	13	32501	252425	70643505
Drug withdrawal syndrome	72.38	26.33	82	32432	32633	70863297
Urinary tract infection	70.83	26.33	14	32500	248755	70647175
Asthenia	70.14	26.33	64	32450	457602	70438328
Hypersensitivity	67.41	26.33	12	32502	229800	70666130
Product dose omission issue	66.82	26.33	10	32504	217458	70678472
Pulmonary oedema	66.25	26.33	128	32386	82150	70813780
Alopecia	66.14	26.33	7	32507	198483	70697447
Swelling	64.52	26.33	6	32508	188533	70707397
Weight increased	64.22	26.33	16	32498	242315	70653615
Infection	64.06	26.33	10	32504	210775	70685155
Abdominal discomfort	63.42	26.33	11	32503	214647	70681283
Sepsis	61.32	26.33	18	32496	244527	70651403
Weight decreased	61.28	26.33	33	32481	310455	70585475
Electrocardiogram QRS complex prolonged	60.89	26.33	44	32470	9762	70886168
Malaise	60.07	26.33	66	32448	432866	70463064
Haemoglobin decreased	59.55	26.33	11	32503	205148	70690782
White blood cell count decreased	59.34	26.33	5	32509	170136	70725794
Drug screen positive	57.67	26.33	35	32479	5805	70890125
Drug abuser	57.53	26.33	35	32479	5829	70890101
Homicide	56.56	26.33	21	32493	1149	70894781
Decreased appetite	56.43	26.33	35	32479	304745	70591185
Sinusitis	56.28	26.33	6	32508	169189	70726741
Drug hypersensitivity	56.17	26.33	25	32489	262434	70633496
Shock	54.14	26.33	79	32435	40346	70855584
Medication error	52.65	26.33	94	32420	56818	70839112
Pancytopenia	51.19	26.33	5	32509	151102	70744828
Platelet count decreased	50.77	26.33	10	32504	178212	70717718
Amnesia	50.65	26.33	88	32426	52067	70843863
Road traffic accident	49.70	26.33	70	32444	34612	70861318
General physical health deterioration	49.70	26.33	23	32491	236008	70659922
Opiates positive	49.62	26.33	18	32496	922	70895008
Therapeutic product effect decreased	47.75	26.33	5	32509	143013	70752917
Musculoskeletal stiffness	47.25	26.33	6	32508	147754	70748176
Stomatitis	47.03	26.33	3	32511	128508	70767422
Urticaria	46.76	26.33	9	32505	163040	70732890
Electrocardiogram QT prolonged	44.46	26.33	110	32404	83407	70812523
Seizure	44.18	26.33	180	32334	177782	70718148
Asthma	43.67	26.33	3	32511	120790	70775140
Therapeutic product effect incomplete	43.27	26.33	3	32511	119879	70776051
Product administration error	42.92	26.33	60	32454	29463	70866467
Abdominal pain	42.30	26.33	57	32457	342070	70553860
Unresponsive to stimuli	42.04	26.33	81	32433	51850	70844080
Muscular weakness	41.04	26.33	7	32507	138329	70757601
Cerebrovascular accident	40.97	26.33	8	32506	143462	70752468
Hepatic fibrosis	40.93	26.33	29	32485	6238	70889692
Sinus tachycardia	40.74	26.33	63	32451	33850	70862080
Victim of sexual abuse	40.44	26.33	13	32501	460	70895470
Blood ethanol increased	40.03	26.33	14	32500	644	70895286
Cardiac failure congestive	39.86	26.33	7	32507	135450	70760480
Withdrawal syndrome	39.81	26.33	53	32461	24851	70871079
Accidental overdose	39.09	26.33	63	32451	35058	70860872
Dizziness	39.00	26.33	98	32416	464043	70431887
Septic shock	37.28	26.33	4	32510	112254	70783676
Thrombocytopenia	37.09	26.33	33	32481	239077	70656853
Discomfort	37.03	26.33	3	32511	105433	70790497
Toxicologic test abnormal	36.93	26.33	16	32498	1311	70894619
Rhabdomyolysis	36.87	26.33	112	32402	95648	70800282
Respiratory acidosis	35.95	26.33	33	32481	10248	70885682
Somnambulism	35.89	26.33	25	32489	5235	70890695
Blood ethanol	35.88	26.33	9	32505	126	70895804
Liver injury	35.69	26.33	66	32448	40969	70854961
Abnormal behaviour	35.58	26.33	60	32454	34649	70861281
Dysarthria	35.22	26.33	84	32430	62229	70833701
Blister	34.92	26.33	3	32511	100523	70795407
Injection site pain	34.78	26.33	6	32508	117613	70778317
Oedema peripheral	34.75	26.33	32	32482	228059	70667871
Brain oedema	34.65	26.33	48	32466	23370	70872560
Chemical submission	34.53	26.33	10	32504	247	70895683
Neuropathy peripheral	34.34	26.33	8	32506	126888	70769042
Amphetamines positive	34.30	26.33	10	32504	253	70895677
Euphoric mood	34.11	26.33	27	32487	6862	70889068
Abdominal distension	34.07	26.33	4	32510	104665	70791265
Alcohol intolerance	33.82	26.33	11	32503	404	70895526
Myocardial fibrosis	33.73	26.33	16	32498	1619	70894311
Postmortem blood drug level	33.20	26.33	10	32504	284	70895646
Influenza	33.18	26.33	6	32508	113694	70782236
Dehydration	32.97	26.33	33	32481	226109	70669821
Bronchitis	32.51	26.33	7	32507	117236	70778694
COVID-19	32.15	26.33	5	32509	105752	70790178
Fall	31.95	26.33	101	32413	443995	70451935
Substance dependence	31.73	26.33	11	32503	493	70895437
Cellulitis	31.66	26.33	4	32510	98924	70797006
Erythema	31.60	26.33	27	32487	199536	70696394
Acute hepatic failure	31.29	26.33	50	32464	27622	70868308
Accidental poisoning	30.92	26.33	15	32499	1595	70894335
Chest pain	30.89	26.33	42	32472	251218	70644712
Oropharyngeal pain	30.57	26.33	4	32510	96306	70799624
Wheezing	29.68	26.33	4	32510	94166	70801764
Psoriasis	29.15	26.33	5	32509	98428	70797502
Serotonin syndrome	28.51	26.33	61	32453	42053	70853877
Impaired driving ability	28.36	26.33	21	32493	4836	70891094
Bradypnoea	28.33	26.33	22	32492	5437	70890493
Physical assault	28.33	26.33	14	32500	1550	70894380
Loss of personal independence in daily activities	28.25	26.33	3	32511	84907	70811023
Delirium tremens	28.05	26.33	11	32503	699	70895231
Sudden death	27.96	26.33	41	32473	21023	70874907
Protein C increased	27.52	26.33	7	32507	104	70895826
Restlessness	27.36	26.33	60	32454	42068	70853862
Renal impairment	27.35	26.33	16	32498	143921	70752009
Dysphagia	27.01	26.33	9	32505	112825	70783105
Suicidal behaviour	26.84	26.33	17	32497	3039	70892891
Pulmonary congestion	26.47	26.33	44	32470	25110	70870820
Leukopenia	26.40	26.33	8	32506	106552	70789378
Chest discomfort	26.35	26.33	12	32502	124369	70771561
Deep vein thrombosis	26.34	26.33	9	32505	111033	70784897

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AE05	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Phenol and derivatives
MeSH PA	D000871	Anthelmintics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D000977	Antiparasitic Agents
MeSH PA	D000980	Antiplatyhelmintic Agents
MeSH PA	D004202	Disinfectants
MeSH PA	D012556	Schistosomicides
CHEBI has role	CHEBI:33904	molluscicides
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Antiseptic preparation	indication	261276004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.85	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.93		DRUG MATRIX
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN		IC50	5.74		DRUG MATRIX

External reference:

ID	Source
4019458	VUID
N0000147580	NUI
D03473	KEGG_DRUG
4018914	VANDF
4019458	VANDF
C0055463	UMLSCUI
CHEBI:34393	CHEBI
CHEMBL398440	ChEMBL_ID
DB11121	DRUGBANK_ID
2723	PUBCHEM_CID
492	INN_ID
C007027	MESH_SUPPLEMENTAL_RECORD_UI
0F32U78V2Q	UNII
20877	RXNORM
4423	MMSL
72857	MMSL
003140	NDDF
003202	NDDF
126151007	SNOMEDCT_US
398713003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Antibacterial Hand	HUMAN OTC DRUG LABEL	1	0404-4438	SOAP	6.10 g	TOPICAL	OTC monograph not final	11 sections
Antibacterial	HUMAN OTC DRUG LABEL	1	0404-4441	LIQUID	6.05 g	TOPICAL	OTC monograph not final	11 sections
Antimicrobial Hand Wash	HUMAN OTC DRUG LABEL	1	0404-5987	SOAP	6 mg	TOPICAL	OTC monograph not final	11 sections
Antimicrobial Hand Wash	HUMAN OTC DRUG LABEL	1	0404-5990	SOAP	6 mg	TOPICAL	OTC monograph not final	11 sections
Blistex Foille Medicated First Aid	HUMAN OTC DRUG LABEL	2	10157-9302	OINTMENT	0.10 g	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
PC511 ANTIMICROBIAL	HUMAN OTC DRUG LABEL	1	10685-511	SOAP	3 g	TOPICAL	OTC monograph not final	9 sections
PC529 ULTREX	HUMAN OTC DRUG LABEL	1	10685-529	SOAP	2.50 g	TOPICAL	OTC monograph not final	9 sections
PC537 E-2 BRUTE	HUMAN OTC DRUG LABEL	1	10685-537	SOAP	25 g	TOPICAL	OTC monograph not final	9 sections
PC557 PALPON	HUMAN OTC DRUG LABEL	1	10685-557	SOAP	2.50 g	TOPICAL	OTC monograph not final	9 sections
NAMICO ANTISEPTIC HAND CLEANER 557	HUMAN OTC DRUG LABEL	1	10685-978	SOAP	2.50 g	TOPICAL	OTC monograph not final	9 sections
Derma CIDOL 2000	HUMAN OTC DRUG LABEL	1	10802-8081	LIQUID	0.50 g	TOPICAL	OTC monograph not final	8 sections
Kindest Kare Hand Antimicrobial Handwash	HUMAN OTC DRUG LABEL	1	11084-036	SOAP	1 g	TOPICAL	OTC MONOGRAPH NOT FINAL	12 sections
PureBac Foam Wash	HUMAN OTC DRUG LABEL	1	11084-131	LIQUID	0.50 mL	TOPICAL	OTC monograph not final	9 sections
Refresh PureBac Foam	HUMAN OTC DRUG LABEL	1	11084-160	LIQUID	5 g	TOPICAL	OTC monograph not final	10 sections
Acute-Kare Healthcare Personnel Handwash	HUMAN OTC DRUG LABEL	1	11084-800	SOAP	1 g	TOPICAL	OTC monograph not final	12 sections
Chloroxylenol	HUMAN OTC DRUG LABEL	1	11344-562	LIQUID	3.09 g	TOPICAL	OTC monograph not final	12 sections
chloroxylenol	HUMAN OTC DRUG LABEL	1	11344-710	LIQUID	3.09 mg	TOPICAL	OTC monograph not final	11 sections
chloroxylenol	HUMAN OTC DRUG LABEL	1	11344-710	LIQUID	3.09 mg	TOPICAL	OTC monograph not final	11 sections
antibacterial	HUMAN OTC DRUG LABEL	1	11344-713	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
antibacterial	HUMAN OTC DRUG LABEL	1	11344-713	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh Antibacterial Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1005	LIQUID	2.50 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh Antibacterial Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1005	LIQUID	2.50 mg	TOPICAL	OTC monograph not final	11 sections
Lemon Drop Gentle Antiseptic	HUMAN OTC DRUG LABEL	1	11429-1006	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
Lemon Drop Gentle Antiseptic	HUMAN OTC DRUG LABEL	1	11429-1006	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
Derma 1 Healthcare Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1007	LIQUID	4 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh Healthcare Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1008	LIQUID	7.50 mg	TOPICAL	OTC monograph not final	11 sections
Pink Antibacterial	HUMAN OTC DRUG LABEL	1	11429-1009	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh Dye Free Antibacterial Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1010	SOLUTION	2.50 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh E-2 Sanitizer Cleanser with PCMX	HUMAN OTC DRUG LABEL	1	11429-1011	LIQUID	5 mg	TOPICAL	OTC monograph not final	10 sections
Antiseptic Hand	HUMAN OTC DRUG LABEL	1	16496-544	SOAP	3 mg	TOPICAL	OTC monograph not final	10 sections