chloroxylenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3094 88-04-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chloroxylenol sodium
  • chloroxylenol
  • benzytol
  • parametaxylenol
a antiseptic halogenated phenol, non-toxic, non-corrosive, non-staining with high phenol coefficient, it may be applied directly to a wound and shows no chemical reactivity toward blood
  • Molecular weight: 156.61
  • Formula: C8H9ClO
  • CLOGP: 3.48
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -2.26
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 6856.07 25.31 2248 16246 143425 63327103
Toxicity to various agents 4132.56 25.31 1795 16699 245455 63225073
Drug abuse 2241.18 25.31 826 17668 71692 63398836
Cardio-respiratory arrest 1337.84 25.31 540 17954 59419 63411109
Intentional overdose 1233.63 25.31 542 17952 73610 63396918
Overdose 918.06 25.31 510 17984 114568 63355960
Suicide attempt 774.96 25.31 370 18124 60548 63409980
Alcohol interaction 529.13 25.31 126 18368 2283 63468245
Suspected suicide 467.73 25.31 141 18353 6427 63464101
Respiratory arrest 377.42 25.31 186 18308 32459 63438069
Intentional product misuse 373.09 25.31 228 18266 60689 63409839
Cardiac arrest 353.15 25.31 258 18236 92287 63378241
Death 308.72 25.31 456 18038 373925 63096603
Exposure to toxic agent 289.15 25.31 94 18400 5493 63465035
Alcohol poisoning 273.64 25.31 71 18423 1848 63468680
Alcohol use 234.98 25.31 64 18430 2015 63468513
Coma 215.36 25.31 166 18328 64198 63406330
Somnolence 195.43 25.31 250 18244 178435 63292093
Alcohol abuse 187.48 25.31 54 18440 2092 63468436
Drug ineffective 177.10 25.31 44 18450 1044721 62425807
Agitation 131.31 25.31 121 18373 59636 63410892
Pain 123.59 25.31 32 18462 740596 62729932
Mydriasis 120.09 25.31 62 18432 11894 63458634
Poisoning deliberate 117.97 25.31 60 18434 11158 63459370
Loss of consciousness 116.14 25.31 157 18337 117964 63352564
Diarrhoea 113.57 25.31 34 18460 715332 62755196
Poisoning 103.99 25.31 59 18435 13641 63456887
Alcoholism 103.92 25.31 33 18461 1785 63468743
Substance abuse 102.29 25.31 42 18452 4765 63465763
Arthralgia 102.11 25.31 21 18473 569689 62900839
Fatigue 99.48 25.31 69 18425 887959 62582569
Blood alcohol increased 92.35 25.31 24 18470 628 63469900
Myocarditis 90.81 25.31 49 18445 10276 63460252
Seizure 89.73 25.31 148 18346 132486 63338042
Intentional self-injury 89.65 25.31 68 18426 25619 63444909
Rash 88.28 25.31 27 18467 560844 62909684
Drug dependence 88.08 25.31 66 18428 24417 63446111
Postmortem blood drug level abnormal 85.24 25.31 20 18474 338 63470190
Dyspnoea 79.91 25.31 47 18447 661266 62809262
Suicidal ideation 78.76 25.31 94 18400 62327 63408201
Victim of sexual abuse 77.02 25.31 21 18473 663 63469865
Alopecia 75.78 25.31 6 18488 337530 63132998
Drug use disorder 74.70 25.31 34 18460 4950 63465578
Chemical submission 68.44 25.31 16 18478 266 63470262
Drug intolerance 67.86 25.31 6 18488 308655 63161873
Drug interaction 67.68 25.31 182 18312 228949 63241579
Abdominal discomfort 66.00 25.31 8 18486 320877 63149651
Headache 65.83 25.31 53 18441 633188 62837340
Off label use 64.62 25.31 61 18433 674401 62796127
Aggression 64.44 25.31 54 18440 23444 63447084
Pain in extremity 64.09 25.31 10 18484 331476 63139052
Hypersensitivity 63.50 25.31 6 18488 292679 63177849
Depressed level of consciousness 63.21 25.31 84 18410 61994 63408534
Pneumonia 61.71 25.31 28 18466 456739 63013789
Swelling 61.49 25.31 5 18489 275373 63195155
Drug withdrawal syndrome 59.56 25.31 55 18439 27139 63443389
Pruritus 59.36 25.31 16 18478 361437 63109091
Pyrexia 58.80 25.31 32 18462 470446 63000082
Rheumatoid arthritis 58.40 25.31 4 18490 253815 63216713
Condition aggravated 56.96 25.31 23 18471 402194 63068334
Peripheral swelling 53.77 25.31 7 18487 265935 63204593
Somnambulism 53.52 25.31 28 18466 5515 63465013
Arthropathy 50.42 25.31 5 18489 234787 63235741
Congestive hepatopathy 50.27 25.31 22 18472 2920 63467608
Electrocardiogram ST segment elevation 50.20 25.31 24 18470 3903 63466625
Tachycardia 50.07 25.31 108 18386 118048 63352480
Nasopharyngitis 48.38 25.31 8 18486 254249 63216279
Product administration interrupted 48.33 25.31 25 18469 4811 63465717
Asthenia 48.03 25.31 26 18468 383578 63086950
Asphyxia 47.93 25.31 27 18467 6154 63464374
Systemic lupus erythematosus 46.06 25.31 4 18490 208914 63261614
Sopor 45.03 25.31 43 18451 22121 63448407
Anaemia 44.51 25.31 15 18479 293415 63177113
Liver injury 44.23 25.31 70 18424 60450 63410078
Infection 44.07 25.31 7 18487 229166 63241362
Electrocardiogram QT prolonged 43.71 25.31 69 18425 59461 63411067
Drug hypersensitivity 41.98 25.31 19 18475 310668 63159860
Substance use disorder 41.17 25.31 10 18484 197 63470331
Product dose omission issue 41.12 25.31 9 18485 234304 63236224
Urinary tract infection 41.07 25.31 13 18481 264671 63205857
Victim of chemical submission 40.35 25.31 12 18482 520 63470008
Amnesia 40.21 25.31 64 18430 55521 63415007
Back pain 39.20 25.31 14 18480 264131 63206397
Sinusitis 39.18 25.31 9 18485 226644 63243884
Metabolic acidosis 38.41 25.31 56 18438 45013 63425515
Cough 37.87 25.31 19 18475 292724 63177804
Hepatic failure 37.44 25.31 49 18445 35607 63434921
Therapeutic product effect decreased 36.91 25.31 6 18488 193181 63277347
Weight increased 36.73 25.31 15 18479 260777 63209751
Wound 36.32 25.31 3 18491 163260 63307268
Treatment failure 36.25 25.31 7 18487 199036 63271492
Nausea 36.18 25.31 128 18366 854343 62616185
Electrocardiogram QRS complex prolonged 35.69 25.31 22 18472 5916 63464612
Protein C increased 35.57 25.31 8 18486 111 63470417
Hepatic encephalopathy 35.29 25.31 28 18466 11254 63459274
Homicide 35.02 25.31 10 18484 375 63470153
Discomfort 34.81 25.31 4 18490 167370 63303158
Neutropenia 34.43 25.31 5 18489 175000 63295528
Abnormal behaviour 33.35 25.31 36 18458 21390 63449138
Musculoskeletal stiffness 32.57 25.31 7 18487 184611 63285917
Sinus tachycardia 31.34 25.31 37 18457 24231 63446297
Substance dependence 31.28 25.31 8 18486 196 63470332
Constipation 29.99 25.31 14 18480 224929 63245599
Malaise 29.81 25.31 47 18447 415907 63054621
Induced abortion failed 29.61 25.31 8 18486 244 63470284
Ventricular tachycardia 28.38 25.31 32 18462 19947 63450581
Hypotension 28.23 25.31 155 18339 272449 63198079
Accidental death 28.11 25.31 13 18481 1963 63468565
Lower respiratory tract infection 27.92 25.31 3 18491 132304 63338224
Congenital umbilical hernia 27.89 25.31 8 18486 305 63470223
Road traffic accident 27.63 25.31 43 18451 36589 63433939
Shock 27.40 25.31 34 18460 23429 63447099
Encephalopathy 27.29 25.31 44 18450 38576 63431952
Disinhibition 26.86 25.31 10 18484 873 63469655
Haemoglobin decreased 26.73 25.31 5 18489 145480 63325048
Respiratory depression 26.71 25.31 26 18468 13689 63456839
Accidental overdose 25.98 25.31 33 18461 23276 63447252
Unresponsive to stimuli 25.93 25.31 40 18454 33776 63436752

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5847.59 27.07 2215 19946 96881 34837889
Completed suicide 4145.62 27.07 1729 20432 96439 34838331
Toxicity to various agents 3779.12 27.07 2020 20141 198342 34736428
Cardio-respiratory arrest 879.75 27.07 504 21657 54769 34880001
Intentional overdose 830.86 27.07 448 21713 43226 34891544
Overdose 661.32 27.07 509 21652 90550 34844220
Alcohol abuse 578.77 27.07 184 21977 4506 34930264
Intentional product misuse 556.51 27.07 351 21810 45260 34889510
Alcohol interaction 538.47 27.07 156 22005 2757 34932013
Suicide attempt 494.58 27.07 308 21853 38808 34895962
Suspected suicide 400.99 27.07 140 22021 4608 34930162
Drug dependence 376.69 27.07 218 21943 23999 34910771
Alcohol poisoning 350.38 27.07 118 22043 3475 34931295
Substance abuse 306.17 27.07 131 22030 7510 34927260
Coma 264.08 27.07 224 21937 45454 34889316
Exposure to toxic agent 223.22 27.07 85 22076 3590 34931180
Asphyxia 218.43 27.07 100 22061 6735 34928035
Respiratory depression 217.90 27.07 133 22028 16112 34918658
Aggression 206.74 27.07 182 21979 38782 34895988
Poisoning deliberate 202.30 27.07 99 22062 7745 34927025
Respiratory arrest 196.68 27.07 154 22007 27889 34906881
Alcohol use 178.17 27.07 70 22091 3218 34931552
Diarrhoea 142.84 27.07 36 22125 389876 34544894
Drug ineffective 133.18 27.07 62 22099 456689 34478081
Pneumonia 126.15 27.07 37 22124 362590 34572180
Poisoning 124.06 27.07 84 22077 12142 34922628
Death 120.45 27.07 534 21627 397515 34537255
Cardiac arrest 118.76 27.07 216 21945 95943 34838827
Anaemia 117.03 27.07 8 22153 233327 34701443
Blood alcohol increased 116.98 27.07 36 22125 787 34933983
Incorrect route of product administration 113.82 27.07 86 22075 14759 34920011
Pyrexia 112.13 27.07 36 22125 332977 34601793
Substance use disorder 106.19 27.07 33 22128 746 34934024
Fatigue 103.80 27.07 53 22108 370600 34564170
Drug use disorder 102.40 27.07 51 22110 4140 34930630
Intentional product use issue 101.46 27.07 155 22006 59661 34875109
Miosis 93.14 27.07 64 22097 9471 34925299
Dyspnoea 92.60 27.07 63 22098 376719 34558051
Suicidal ideation 91.18 27.07 120 22041 40268 34894502
Depressed level of consciousness 88.64 27.07 122 22039 42719 34892051
Rash 88.57 27.07 17 22144 222735 34712035
Drug withdrawal syndrome 88.22 27.07 84 22077 19750 34915020
Intentional self-injury 86.63 27.07 71 22090 13700 34921070
Prescription drug used without a prescription 83.18 27.07 36 22125 2118 34932652
Agitation 82.58 27.07 138 22023 57261 34877509
Off label use 80.24 27.07 89 22072 419435 34515335
Neutropenia 79.64 27.07 5 22156 156773 34777997
Alcohol withdrawal syndrome 74.79 27.07 30 22131 1456 34933314
Cough 72.78 27.07 6 22155 150134 34784636
Mydriasis 71.68 27.07 49 22112 7188 34927582
Sopor 70.99 27.07 60 22101 12076 34922694
Drug interaction 65.58 27.07 300 21861 225646 34709124
Sepsis 63.49 27.07 14 22147 166547 34768223
Accidental death 63.31 27.07 31 22130 2425 34932345
Tachycardia 62.10 27.07 154 22007 84618 34850152
Medication error 60.85 27.07 78 22083 25487 34909283
Arthralgia 59.59 27.07 17 22144 170024 34764746
Condition aggravated 59.07 27.07 24 22137 192172 34742598
Pain 59.05 27.07 28 22133 204647 34730123
Alcoholism 57.79 27.07 31 22130 2934 34931836
Constipation 57.58 27.07 9 22152 136973 34797797
Platelet count decreased 54.78 27.07 6 22155 119711 34815059
Nausea 54.66 27.07 82 22079 339826 34594944
Road traffic accident 54.27 27.07 61 22100 17389 34917381
Loss of consciousness 54.15 27.07 144 22017 82523 34852247
Pain in extremity 53.88 27.07 8 22153 126505 34808265
Alcohol intolerance 52.93 27.07 17 22144 429 34934341
Drug screen positive 52.11 27.07 32 22129 3911 34930859
Withdrawal syndrome 52.08 27.07 51 22110 12404 34922366
Asthenia 51.33 27.07 48 22113 245203 34689567
Amnesia 50.98 27.07 73 22088 26490 34908280
Haemoglobin decreased 48.40 27.07 9 22152 120763 34814007
Pancytopenia 48.40 27.07 3 22158 95154 34839616
Decreased appetite 46.10 27.07 24 22137 166368 34768402
Ex-drug abuser 45.84 27.07 12 22149 142 34934628
Infection 45.84 27.07 3 22158 90912 34843858
Pruritus 44.80 27.07 17 22144 141964 34792806
Product dose omission issue 43.74 27.07 11 22150 119700 34815070
Somnolence 42.71 27.07 161 22000 110955 34823815
Metabolic acidosis 42.69 27.07 89 22072 43591 34891179
Weight decreased 42.46 27.07 30 22131 176271 34758499
Back pain 41.14 27.07 13 22148 121776 34812994
General physical health deterioration 41.06 27.07 15 22146 128254 34806516
Oedema peripheral 38.37 27.07 14 22147 119798 34814972
Hepatic fibrosis 38.23 27.07 28 22133 4579 34930191
Pulmonary oedema 37.60 27.07 89 22072 47440 34887330
Drug abuser 37.34 27.07 26 22135 3928 34930842
Opiates positive 37.30 27.07 14 22147 567 34934203
Peripheral swelling 37.22 27.07 3 22158 76538 34858232
Impaired driving ability 36.41 27.07 22 22139 2611 34932159
Cerebrovascular accident 34.66 27.07 6 22155 84805 34849965
Urinary tract infection 34.25 27.07 6 22155 84075 34850695
Dysarthria 34.13 27.07 71 22090 34711 34900059
Homicide 33.85 27.07 15 22146 934 34933836
Cardiac failure congestive 33.79 27.07 6 22155 83264 34851506
Neuropathy peripheral 33.79 27.07 6 22155 83257 34851513
Foetal alcohol syndrome 32.35 27.07 9 22152 136 34934634
Atrial fibrillation 31.94 27.07 19 22142 122374 34812396
Septic shock 31.85 27.07 4 22157 71830 34862940
Physical assault 31.16 27.07 15 22146 1130 34933640
Brain oedema 31.06 27.07 41 22120 13780 34920990
Thrombocytopenia 31.00 27.07 32 22129 156215 34778555
Abdominal pain 30.81 27.07 35 22126 163583 34771187
Electrocardiogram repolarisation abnormality 29.91 27.07 14 22147 990 34933780
Pleural effusion 28.81 27.07 8 22153 81538 34853232
Blood ethanol 28.81 27.07 8 22153 120 34934650
Renal impairment 28.67 27.07 12 22149 94501 34840269
Cardiac failure 28.64 27.07 11 22150 91237 34843533
Myocardial infarction 28.61 27.07 21 22140 121064 34813706
COVID-19 28.56 27.07 7 22154 77543 34857227
Muscular weakness 28.00 27.07 6 22155 72891 34861879
Malaise 27.73 27.07 47 22114 185778 34748992
Dehydration 27.65 27.07 25 22136 129944 34804826
Dizziness 27.63 27.07 61 22100 218460 34716310
Myocardial fibrosis 27.57 27.07 14 22147 1183 34933587

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 10375.97 25.94 3927 32290 241840 79466331
Drug abuse 8027.78 25.94 2926 33291 159765 79548406
Toxicity to various agents 7674.64 25.94 3716 32501 417824 79290347
Cardio-respiratory arrest 2175.94 25.94 1034 35183 107476 79600695
Intentional overdose 1694.29 25.94 866 35351 105094 79603077
Overdose 1304.71 25.94 889 35328 183317 79524854
Alcohol interaction 906.45 25.94 244 35973 4630 79703541
Intentional product misuse 885.55 25.94 546 35671 94619 79613552
Suicide attempt 802.54 25.94 488 35729 82444 79625727
Suspected suicide 791.47 25.94 262 35955 10314 79697857
Alcohol abuse 593.06 25.94 179 36038 5184 79702987
Respiratory arrest 544.41 25.94 334 35883 57216 79650955
Alcohol poisoning 524.88 25.94 159 36058 4662 79703509
Death 520.85 25.94 924 35293 565590 79142581
Exposure to toxic agent 491.47 25.94 177 36040 8981 79699190
Coma 440.43 25.94 365 35852 100284 79607887
Drug dependence 430.44 25.94 254 35963 40515 79667656
Cardiac arrest 423.09 25.94 453 35764 171643 79536528
Alcohol use 342.68 25.94 115 36102 4716 79703455
Substance abuse 337.83 25.94 140 36077 10386 79697785
Drug ineffective 318.17 25.94 55 36162 1080858 78627313
Poisoning deliberate 302.94 25.94 155 36062 18673 79689498
Diarrhoea 239.43 25.94 54 36163 880435 78827736
Asphyxia 228.61 25.94 110 36107 11610 79696561
Aggression 216.83 25.94 182 36035 50776 79657395
Poisoning 204.53 25.94 133 36084 25139 79683032
Respiratory depression 198.47 25.94 135 36082 27495 79680676
Fatigue 194.67 25.94 90 36127 929637 78778534
Agitation 187.90 25.94 229 35988 99486 79608685
Pain 187.47 25.94 45 36172 703757 79004414
Blood alcohol increased 186.18 25.94 53 36164 1242 79706929
Arthralgia 181.72 25.94 23 36194 571780 79136391
Rash 172.75 25.94 28 36189 578330 79129841
Dyspnoea 165.76 25.94 92 36125 856933 78851238
Drug use disorder 165.10 25.94 80 36137 8571 79699600
Off label use 164.79 25.94 105 36112 907110 78801061
Mydriasis 158.02 25.94 99 36118 17544 79690627
Pneumonia 155.86 25.94 53 36164 660193 79047978
Pyrexia 154.23 25.94 58 36159 678651 79029520
Intentional self-injury 144.55 25.94 119 36098 32300 79675871
Somnolence 143.95 25.94 328 35889 238653 79469518
Substance use disorder 142.14 25.94 40 36177 898 79707273
Anaemia 138.65 25.94 19 36198 444996 79263175
Depressed level of consciousness 137.01 25.94 193 36024 96459 79611712
Condition aggravated 129.47 25.94 34 36183 501090 79207081
Incorrect route of product administration 128.80 25.94 115 36102 34814 79673357
Loss of consciousness 123.48 25.94 250 35967 167693 79540478
Pain in extremity 119.81 25.94 13 36204 364525 79343646
Nausea 117.88 25.94 158 36059 957038 78751133
Miosis 117.80 25.94 79 36138 15710 79692461
Pruritus 115.73 25.94 20 36197 394628 79313543
Suicidal ideation 101.64 25.94 148 36069 76192 79631979
Alcoholism 101.11 25.94 44 36173 3679 79704492
Headache 100.09 25.94 90 36127 653682 79054489
Drug interaction 99.28 25.94 412 35805 414771 79293400
Cough 98.33 25.94 23 36194 366766 79341405
Drug intolerance 96.16 25.94 6 36211 264113 79444058
Neutropenia 95.17 25.94 10 36207 287700 79420471
Peripheral swelling 92.81 25.94 8 36209 269609 79438562
Accidental death 92.01 25.94 43 36174 4248 79703923
Tachycardia 91.83 25.94 230 35987 177538 79530633
Infusion related reaction 91.05 25.94 3 36214 230234 79477937
Postmortem blood drug level abnormal 90.58 25.94 26 36191 628 79707543
Intentional product use issue 89.51 25.94 207 36010 151905 79556266
Nasopharyngitis 88.85 25.94 7 36210 253874 79454297
Asthenia 84.97 25.94 65 36152 511624 79196547
Sopor 84.59 25.94 89 36128 32921 79675250
Metabolic acidosis 83.44 25.94 141 36076 82388 79625783
Back pain 81.65 25.94 19 36198 304161 79404010
Prescription drug used without a prescription 81.65 25.94 39 36178 4046 79704125
Constipation 79.39 25.94 16 36201 283034 79425137
Alopecia 79.25 25.94 7 36210 231348 79476823
Urinary tract infection 78.08 25.94 15 36202 274497 79433674
Hypersensitivity 77.46 25.94 13 36204 262226 79445945
Infection 75.96 25.94 10 36207 241702 79466469
Alcohol withdrawal syndrome 75.68 25.94 30 36187 1981 79706190
Abdominal discomfort 75.01 25.94 12 36205 250715 79457456
Weight decreased 74.60 25.94 34 36183 355164 79353007
Product dose omission issue 71.51 25.94 13 36204 247524 79460647
Weight increased 71.20 25.94 19 36198 277367 79430804
Electrocardiogram QRS complex prolonged 70.88 25.94 50 36167 10783 79697388
Malaise 70.71 25.94 71 36146 489798 79218373
Drug withdrawal syndrome 70.68 25.94 83 36134 34635 79673536
Swelling 70.46 25.94 8 36209 216703 79491468
Decreased appetite 68.52 25.94 35 36182 342383 79365788
White blood cell count decreased 66.41 25.94 5 36212 188283 79519888
Pulmonary oedema 65.53 25.94 132 36085 88122 79620049
Sepsis 64.49 25.94 21 36196 269407 79438764
Haemoglobin decreased 63.44 25.94 12 36205 222107 79486064
Chemical submission 63.23 25.94 17 36200 320 79707851
General physical health deterioration 63.21 25.94 23 36194 275215 79432956
Seizure 62.25 25.94 208 36009 188626 79519545
Drug hypersensitivity 62.15 25.94 29 36188 298887 79409284
Opiates positive 59.89 25.94 21 36196 983 79707188
Sinusitis 59.28 25.94 9 36208 195492 79512679
Musculoskeletal stiffness 58.05 25.94 6 36211 175002 79533169
Medication error 57.45 25.94 108 36109 68534 79639637
Drug abuser 57.02 25.94 35 36182 5978 79702193
Pancytopenia 56.79 25.94 5 36212 165740 79542431
Drug screen positive 56.75 25.94 35 36182 6028 79702143
Platelet count decreased 56.70 25.94 10 36207 194654 79513517
Homicide 56.47 25.94 21 36196 1165 79707006
Therapeutic product effect decreased 55.99 25.94 5 36212 163858 79544313
Urticaria 55.08 25.94 9 36208 185192 79522979
Dizziness 53.07 25.94 99 36118 526342 79181829
Therapeutic product effect incomplete 52.19 25.94 3 36214 141642 79566529
Stomatitis 51.45 25.94 4 36213 146753 79561418
Victim of sexual abuse 51.33 25.94 16 36201 516 79707655
Withdrawal syndrome 51.04 25.94 62 36155 26792 79681379
Shock 50.23 25.94 79 36138 43469 79664702
Amnesia 48.82 25.94 96 36121 62961 79645210
Abdominal pain 48.03 25.94 64 36153 389505 79318666
Blood ethanol 47.63 25.94 12 36205 173 79707998
Muscular weakness 47.37 25.94 8 36209 160721 79547450
Electrocardiogram QT prolonged 45.63 25.94 116 36101 90270 79617901
Amphetamines positive 44.71 25.94 13 36204 329 79707842
Postmortem blood drug level 44.49 25.94 13 36204 335 79707836
Product administration error 44.20 25.94 63 36154 31783 79676388
Asthma 43.86 25.94 5 36212 135090 79573081
Systemic lupus erythematosus 43.33 25.94 3 36214 121146 79587025
Road traffic accident 43.32 25.94 74 36143 43590 79664581
Blister 42.61 25.94 3 36214 119473 79588698
Cardiac failure congestive 42.16 25.94 7 36210 142395 79565776
COVID-19 41.98 25.94 10 36207 157664 79550507
Accidental overdose 41.82 25.94 69 36148 39512 79668659
Septic shock 41.27 25.94 4 36213 122797 79585374
Somnambulism 41.17 25.94 28 36189 5693 79702478
Cerebrovascular accident 41.04 25.94 10 36207 155282 79552889
Unresponsive to stimuli 40.87 25.94 83 36134 55705 79652466
Discomfort 39.92 25.94 5 36212 125612 79582559
Brain oedema 39.60 25.94 53 36164 25210 79682961
Blood ethanol increased 39.45 25.94 14 36203 679 79707492
Congestive hepatopathy 39.42 25.94 25 36192 4522 79703649
Thrombocytopenia 38.72 25.94 38 36179 265221 79442950
Sinus tachycardia 38.54 25.94 64 36153 36844 79671327
Victim of chemical submission 38.54 25.94 13 36204 541 79707630
Chest pain 38.34 25.94 43 36174 282261 79425910
Electrocardiogram ST segment elevation 37.78 25.94 31 36186 8366 79699805
Respiratory acidosis 37.61 25.94 35 36182 11165 79697006
Neuropathy peripheral 37.54 25.94 9 36208 141296 79566875
Hepatic fibrosis 37.29 25.94 29 36188 7251 79700920
Injection site pain 37.09 25.94 7 36210 129831 79578340
Influenza 36.99 25.94 7 36210 129599 79578572
Toxicologic test abnormal 36.69 25.94 16 36201 1344 79706827
Acute hepatic failure 36.64 25.94 56 36161 30057 79678114
Abnormal behaviour 36.49 25.94 62 36155 36359 79671812
Wheezing 36.21 25.94 5 36212 116659 79591512
Alcohol intolerance 36.20 25.94 12 36205 473 79707698
Dehydration 35.71 25.94 36 36181 248151 79460020
Loss of personal independence in daily activities 35.39 25.94 3 36214 102577 79605594
Abdominal distension 35.15 25.94 6 36211 119644 79588527
Fall 34.66 25.94 110 36107 487519 79220652
Liver injury 34.31 25.94 78 36139 56536 79651635
Erythema 33.74 25.94 31 36186 223259 79484912
Rhabdomyolysis 33.42 25.94 113 36104 103018 79605153
Bronchitis 33.40 25.94 9 36208 130635 79577536
Dysarthria 33.31 25.94 86 36131 67536 79640635
Oropharyngeal pain 33.21 25.94 5 36212 109348 79598823
Myocardial fibrosis 33.12 25.94 16 36201 1702 79706469
Cellulitis 33.09 25.94 5 36212 109055 79599116
Bradypnoea 32.95 25.94 25 36192 6027 79702144
Hypoaesthesia 32.04 25.94 21 36196 179331 79528840
Substance dependence 31.83 25.94 11 36206 493 79707678
Renal impairment 31.71 25.94 16 36201 157767 79550404
Euphoric mood 31.61 25.94 27 36190 7699 79700472
Physical assault 31.04 25.94 15 36202 1596 79706575
Therapy non-responder 31.03 25.94 3 36214 92302 79615869
Lower respiratory tract infection 31.02 25.94 10 36207 129210 79578961
C-reactive protein increased 30.95 25.94 10 36207 129017 79579154
Accidental poisoning 30.64 25.94 15 36202 1642 79706529
Oedema peripheral 30.50 25.94 42 36175 252246 79455925
Drug level increased 30.24 25.94 60 36157 39591 79668580
Gastrointestinal disorder 30.16 25.94 9 36208 122196 79585975
Dysphagia 30.13 25.94 9 36208 122127 79586044
Behaviour disorder 29.87 25.94 24 36193 6289 79701882
Leukopenia 29.83 25.94 8 36209 116505 79591666
Neutrophil count decreased 29.22 25.94 4 36213 93955 79614216
Osteoarthritis 28.93 25.94 3 36214 87306 79620865
Myocarditis 28.71 25.94 42 36175 21691 79686480
Hypothermia 28.67 25.94 43 36174 22703 79685468
Musculoskeletal pain 28.22 25.94 6 36211 102348 79605823
Upper respiratory tract infection 28.08 25.94 4 36213 91164 79617007
Delirium tremens 27.74 25.94 11 36206 727 79707444
Protein C increased 27.59 25.94 7 36210 104 79708067
Abdominal pain upper 27.32 25.94 37 36180 223782 79484389
Chills 26.98 25.94 20 36197 160214 79547957
Pulmonary embolism 26.93 25.94 23 36194 171631 79536540
Haematochezia 26.63 25.94 4 36213 87641 79620530
Impaired driving ability 26.50 25.94 21 36196 5394 79702777
Inappropriate schedule of product administration 26.19 25.94 14 36203 133614 79574557
Sudden death 26.18 25.94 41 36176 22470 79685701
Serotonin syndrome 26.14 25.94 61 36156 44966 79663205
Suicidal behaviour 26.04 25.94 17 36200 3230 79704941

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AE05 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Phenol and derivatives
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000980 Antiplatyhelmintic Agents
MeSH PA D004202 Disinfectants
MeSH PA D012556 Schistosomicides
CHEBI has role CHEBI:33904 molluscicides
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.85 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2B GPCR Ki 5.93 DRUG MATRIX
Amine oxidase [flavin-containing] A Enzyme IC50 5.74 DRUG MATRIX

External reference:

IDSource
4019458 VUID
N0000147580 NUI
D03473 KEGG_DRUG
4018914 VANDF
4019458 VANDF
C0055463 UMLSCUI
CHEBI:34393 CHEBI
CHEMBL398440 ChEMBL_ID
DB11121 DRUGBANK_ID
2723 PUBCHEM_CID
492 INN_ID
C007027 MESH_SUPPLEMENTAL_RECORD_UI
0F32U78V2Q UNII
20877 RXNORM
4423 MMSL
72857 MMSL
003140 NDDF
003202 NDDF
126151007 SNOMEDCT_US
398713003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Antibacterial Hand HUMAN OTC DRUG LABEL 1 0404-4438 SOAP 6.10 g TOPICAL OTC monograph not final 11 sections
Antibacterial Hand HUMAN OTC DRUG LABEL 1 0404-4438 SOAP 6.10 g TOPICAL OTC monograph not final 11 sections
Antibacterial HUMAN OTC DRUG LABEL 1 0404-4441 LIQUID 6.05 g TOPICAL OTC monograph not final 11 sections
Antibacterial HUMAN OTC DRUG LABEL 1 0404-4441 LIQUID 6.05 g TOPICAL OTC monograph not final 11 sections
Antimicrobial Hand Wash HUMAN OTC DRUG LABEL 1 0404-5987 SOAP 6 mg TOPICAL OTC monograph not final 11 sections
Antimicrobial Hand Wash HUMAN OTC DRUG LABEL 1 0404-5990 SOAP 6 mg TOPICAL OTC monograph not final 11 sections
Blistex Foille Medicated First Aid HUMAN OTC DRUG LABEL 2 10157-9302 OINTMENT 0.10 g TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
PC511 ANTIMICROBIAL HUMAN OTC DRUG LABEL 1 10685-511 SOAP 3 g TOPICAL OTC monograph not final 9 sections
PC529 ULTREX HUMAN OTC DRUG LABEL 1 10685-529 SOAP 2.50 g TOPICAL OTC monograph not final 9 sections
PC537 E-2 BRUTE HUMAN OTC DRUG LABEL 1 10685-537 SOAP 25 g TOPICAL OTC monograph not final 9 sections
PC557 PALPON HUMAN OTC DRUG LABEL 1 10685-557 SOAP 2.50 g TOPICAL OTC monograph not final 9 sections
NAMICO ANTISEPTIC HAND CLEANER 557 HUMAN OTC DRUG LABEL 1 10685-978 SOAP 2.50 g TOPICAL OTC monograph not final 9 sections
Derma CIDOL 2000 HUMAN OTC DRUG LABEL 1 10802-8081 LIQUID 0.50 g TOPICAL OTC monograph not final 8 sections
Kindest Kare Hand Antimicrobial Handwash HUMAN OTC DRUG LABEL 1 11084-036 SOAP 1 g TOPICAL OTC MONOGRAPH NOT FINAL 12 sections
PureBac Foam Wash HUMAN OTC DRUG LABEL 1 11084-131 LIQUID 0.50 mL TOPICAL OTC monograph not final 18 sections
Refresh PureBac Foam HUMAN OTC DRUG LABEL 1 11084-160 LIQUID 5 g TOPICAL OTC monograph not final 10 sections
Refresh PureBac Foam HUMAN OTC DRUG LABEL 1 11084-160 LIQUID 5 g TOPICAL OTC monograph not final 10 sections
Acute-Kare Healthcare Personnel Handwash HUMAN OTC DRUG LABEL 1 11084-800 SOAP 1 g TOPICAL OTC monograph not final 12 sections
Chloroxylenol HUMAN OTC DRUG LABEL 1 11344-562 LIQUID 3.09 g TOPICAL OTC monograph not final 12 sections
chloroxylenol HUMAN OTC DRUG LABEL 1 11344-710 LIQUID 3.09 mg TOPICAL OTC monograph not final 11 sections
chloroxylenol HUMAN OTC DRUG LABEL 1 11344-710 LIQUID 3.09 mg TOPICAL OTC monograph not final 11 sections
antibacterial HUMAN OTC DRUG LABEL 1 11344-713 LIQUID 3 mg TOPICAL OTC monograph not final 11 sections
antibacterial HUMAN OTC DRUG LABEL 1 11344-713 LIQUID 3 mg TOPICAL OTC monograph not final 11 sections
FoamFresh Antibacterial Hand Wash HUMAN OTC DRUG LABEL 1 11429-1005 LIQUID 2.50 mg TOPICAL OTC monograph not final 11 sections
FoamFresh Antibacterial Hand Wash HUMAN OTC DRUG LABEL 1 11429-1005 LIQUID 2.50 mg TOPICAL OTC monograph not final 11 sections
Lemon Drop Gentle Antiseptic HUMAN OTC DRUG LABEL 1 11429-1006 LIQUID 3 mg TOPICAL OTC monograph not final 11 sections
Lemon Drop Gentle Antiseptic HUMAN OTC DRUG LABEL 1 11429-1006 LIQUID 3 mg TOPICAL OTC monograph not final 11 sections
Derma 1 Healthcare Hand Wash HUMAN OTC DRUG LABEL 1 11429-1007 LIQUID 4 mg TOPICAL OTC monograph not final 11 sections
FoamFresh Healthcare Hand Wash HUMAN OTC DRUG LABEL 1 11429-1008 LIQUID 7.50 mg TOPICAL OTC monograph not final 11 sections
Pink Antibacterial HUMAN OTC DRUG LABEL 1 11429-1009 LIQUID 3 mg TOPICAL OTC monograph not final 11 sections