benfotiamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 308 | 22457-89-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Gastrointestinal haemorrhage | 61.77 | 40.13 | 17 | 122 | 81159 | 63407724 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Eye movement disorder | 80.44 | 70.52 | 15 | 212 | 4112 | 34952592 |
| Oculogyric crisis | 73.06 | 70.52 | 12 | 215 | 1574 | 34955130 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Eye movement disorder | 74.08 | 47.17 | 15 | 387 | 7996 | 79735990 |
| Oculogyric crisis | 68.51 | 47.17 | 12 | 390 | 2940 | 79741046 |
| Movement disorder | 55.81 | 47.17 | 15 | 387 | 27244 | 79716742 |
| Drug interaction | 52.97 | 47.17 | 30 | 372 | 415153 | 79328833 |
| Status epilepticus | 52.29 | 47.17 | 14 | 388 | 25027 | 79718959 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A11DA03 | ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12 Vitamin B1, plain |
| CHEBI has role | CHEBI:22586 | antioxidants |
| CHEBI has role | CHEBI:50267 | protective agents |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
| CHEBI has role | CHEBI:50847 | Immunologic adjuvant |
| CHEBI has role | CHEBI:72470 | provitamin B1s |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.16 | acidic |
| pKa2 | 6.98 | acidic |
| pKa3 | 7.59 | Basic |
| pKa4 | 0.96 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4028227 | VUID |
| N0000177939 | NUI |
| D01255 | KEGG_DRUG |
| 18891 | RXNORM |
| C0053116 | UMLSCUI |
| CHEBI:41039 | CHEBI |
| BFT | PDB_CHEM_ID |
| CHEMBL3183549 | ChEMBL_ID |
| CHEMBL1491875 | ChEMBL_ID |
| DB11748 | DRUGBANK_ID |
| 1300 | INN_ID |
| Y92OUS2H9B | UNII |
| 3032771 | PUBCHEM_CID |
| 23417 | MMSL |
| 366760 | MMSL |
| d08940 | MMSL |
| 703399007 | SNOMEDCT_US |
| 704989003 | SNOMEDCT_US |
| 4028227 | VANDF |
| 005583 | NDDF |
Pharmaceutical products:
None