benfotiamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
308 22457-89-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benfotiamine
  • benfothiamine
  • benzoylthiamine monophosphate
  • betivina
  • bietamine
  • Molecular weight: 466.45
  • Formula: C19H23N4O6PS
  • CLOGP: -0.62
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 155.94
  • ALOGS: -4.07
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 62.35 38.42 17 111 75934 56216005

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye movement disorder 80.75 76.77 15 201 3846 31693282

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye movement disorder 73.98 42.63 15 373 7425 70920631
Oculogyric crisis 68.61 42.63 12 376 2686 70925370
Movement disorder 56.42 42.63 15 373 24114 70903942
Drug interaction 53.09 42.63 30 358 381411 70546645
Status epilepticus 51.45 42.63 14 374 24512 70903544

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11DA03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12
Vitamin B1, plain
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:50847 Immunologic adjuvant
CHEBI has role CHEBI:72470 provitamin B1s

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.16 acidic
pKa2 6.98 acidic
pKa3 7.59 Basic
pKa4 0.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4028227 VUID
N0000177939 NUI
D01255 KEGG_DRUG
18891 RXNORM
4028227 VANDF
C0053116 UMLSCUI
CHEBI:41039 CHEBI
BFT PDB_CHEM_ID
CHEMBL3183549 ChEMBL_ID
CHEMBL1491875 ChEMBL_ID
DB11748 DRUGBANK_ID
1300 INN_ID
Y92OUS2H9B UNII
2320 PUBCHEM_CID
23417 MMSL
005583 NDDF
703399007 SNOMEDCT_US
704989003 SNOMEDCT_US

Pharmaceutical products:

None