benfotiamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
308 22457-89-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benfotiamine
  • benfothiamine
  • benzoylthiamine monophosphate
  • betivina
  • bietamine
  • Molecular weight: 466.45
  • Formula: C19H23N4O6PS
  • CLOGP: -0.62
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 155.94
  • ALOGS: -4.07
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 61.77 40.13 17 122 81159 63407724

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye movement disorder 80.44 70.52 15 212 4112 34952592
Oculogyric crisis 73.06 70.52 12 215 1574 34955130

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye movement disorder 74.08 47.17 15 387 7996 79735990
Oculogyric crisis 68.51 47.17 12 390 2940 79741046
Movement disorder 55.81 47.17 15 387 27244 79716742
Drug interaction 52.97 47.17 30 372 415153 79328833
Status epilepticus 52.29 47.17 14 388 25027 79718959

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11DA03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12
Vitamin B1, plain
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:50847 Immunologic adjuvant
CHEBI has role CHEBI:72470 provitamin B1s

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.16 acidic
pKa2 6.98 acidic
pKa3 7.59 Basic
pKa4 0.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4028227 VUID
N0000177939 NUI
D01255 KEGG_DRUG
18891 RXNORM
C0053116 UMLSCUI
CHEBI:41039 CHEBI
BFT PDB_CHEM_ID
CHEMBL3183549 ChEMBL_ID
CHEMBL1491875 ChEMBL_ID
DB11748 DRUGBANK_ID
1300 INN_ID
Y92OUS2H9B UNII
3032771 PUBCHEM_CID
23417 MMSL
366760 MMSL
d08940 MMSL
703399007 SNOMEDCT_US
704989003 SNOMEDCT_US
4028227 VANDF
005583 NDDF

Pharmaceutical products:

None