cetylpyridinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quaternary ammonium compounds	3083	7773-52-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cetylpyridinium ceepryn hexadecylpyridinium cetylpyridinium chloride	Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges. Molecular weight: 304.54 Formula: C21H38N CLOGP: 3.74 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 3.88 ALOGS: -7.72 ROTB: 15

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cetylpyridinium
ceepryn
hexadecylpyridinium
cetylpyridinium chloride

Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.

Molecular weight: 304.54
Formula: C21H38N
CLOGP: 3.74
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 3.88
ALOGS: -7.72
ROTB: 15

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrointestinal toxicity	326.60	52.39	70	1960	7671	63479321
Pulmonary toxicity	307.18	52.39	69	1961	9386	63477606
Neoplasm malignant	232.78	52.39	70	1960	29791	63457201
Joint injury	229.12	52.39	69	1961	29503	63457489
Hepatotoxicity	217.92	52.39	70	1960	36971	63450021
C-reactive protein abnormal	199.00	52.39	69	1961	46027	63440965
Therapy non-responder	168.90	52.39	70	1960	75831	63411161
Joint stiffness	162.72	52.39	58	1972	41811	63445181
Musculoskeletal pain	158.94	52.39	71	1959	92206	63394786
Musculoskeletal stiffness	115.08	52.39	72	1958	184546	63302446
Therapeutic product effect incomplete	110.03	52.39	61	1969	124995	63361997
Treatment failure	102.80	52.39	69	1961	198974	63288018
Infection	100.89	52.39	72	1958	229101	63257891
Drug hypersensitivity	89.67	52.39	76	1954	310611	63176381
Arthropathy	81.46	52.39	64	1966	234728	63252264
Pain in extremity	77.49	52.39	72	1958	331414	63155578
Joint swelling	76.25	52.39	71	1959	327595	63159397
Condition aggravated	67.52	52.39	73	1957	402144	63084848
Drug intolerance	64.36	52.39	63	1967	308598	63178394

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Conjunctival scar	37.15	34.76	5	272	134	34956520

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrointestinal toxicity	129.57	31.08	30	1437	8079	79734842
Pulmonary toxicity	115.70	31.08	30	1437	12884	79730037
Neoplasm malignant	92.97	31.08	31	1436	31779	79711142
Joint injury	89.44	31.08	30	1437	31305	79711616
Joint stiffness	77.98	31.08	29	1438	40801	79702120
Therapy non-responder	76.05	31.08	36	1431	92269	79650652
Hepatotoxicity	74.98	31.08	30	1437	51322	79691599
C-reactive protein abnormal	73.20	31.08	29	1438	48338	79694583
Musculoskeletal pain	58.01	31.08	31	1436	102323	79640598
Toxic anterior segment syndrome	53.67	31.08	12	1455	2752	79740169
Conjunctival scar	45.31	31.08	7	1460	210	79742711
Musculoskeletal stiffness	44.99	31.08	32	1435	174976	79567945
Treatment failure	38.87	31.08	29	1438	170457	79572464
Drug hypersensitivity	35.58	31.08	35	1432	298881	79444040
Infection	33.89	31.08	31	1436	241681	79501240

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B05CA01	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives
ATC	D08AJ03	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D09AA07	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	R02AA06	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D003902	Detergents
MeSH PA	D013501	Surface-Active Agents
CHEBI has role	CHEBI:35195	surfactant
CHEBI has role	CHEBI:48218	antiseptics

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Local anesthesia	indication	386761002
Mouth Irritation	indication
Suppression of the Gag Reflex	indication
Hypocupremia	contraindication	19577007
Methemoglobinemia	contraindication	38959009	DOID:10783
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Deficiency of cytochrome-b>5< reductase	contraindication	124184009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Caspase-2	Enzyme	P42575	CASP2_HUMAN		EC50	4.68		CHEMBL
High affinity choline transporter 1	Transporter		SC5A7_MOUSE		Ki	4.49		CHEMBL

External reference:

ID	Source
4019671	VUID
N0000147763	NUI
D07666	KEGG_DRUG
6004-24-6	SECONDARY_CAS_RN
4019096	VANDF
4019671	VANDF
C0007906	UMLSCUI
CHEBI:32915	CHEBI
CHEMBL305906	ChEMBL_ID
DB11073	DRUGBANK_ID
CHEMBL2003538	ChEMBL_ID
CHEMBL34833	ChEMBL_ID
D002594	MESH_DESCRIPTOR_UI
2683	PUBCHEM_CID
CUB7JI0JV3	UNII
2286	RXNORM
4401	MMSL
73038	MMSL
003144	NDDF
11719000	SNOMEDCT_US
387043006	SNOMEDCT_US
395927000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oral-BAnti-Bacterial	HUMAN OTC DRUG LABEL	1	0041-1420	LIQUID	500 ug	DENTAL	OTC monograph not final	26 sections
ParodontaxActive Gum Health Clear Mint	HUMAN OTC DRUG LABEL	1	0135-0650	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	12 sections
ParodontaxActive Gum Health Clear Mint	HUMAN OTC DRUG LABEL	1	0135-0650	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	12 sections
ParodontaxActive Gum Health Mint	HUMAN OTC DRUG LABEL	1	0135-0651	MOUTHWASH	70 mg	ORAL	OTC monograph not final	12 sections
ParodontaxActive Gum Health Mint	HUMAN OTC DRUG LABEL	1	0135-0651	MOUTHWASH	70 mg	ORAL	OTC monograph not final	12 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0869-0299	RINSE	0.07 kg	ORAL	OTC monograph not final	11 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0869-0299	RINSE	0.07 kg	ORAL	OTC monograph not final	11 sections
TheraBreath Healthy Gums	HUMAN OTC DRUG LABEL	1	10237-258	RINSE	0.01 mg	ORAL	OTC MONOGRAPH NOT FINAL	11 sections
Therabreath Plaque Control	HUMAN OTC DRUG LABEL	1	10237-259	RINSE	0.02 mg	ORAL	OTC MONOGRAPH NOT FINAL	11 sections
Orajle Anti-Bacterial Rinse for Bleeding Gums	HUMAN OTC DRUG LABEL	1	10237-721	LIQUID	0.00 mL	ORAL	OTC monograph not final	12 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	11673-299	RINSE	0.70 mg	ORAL	OTC monograph not final	13 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	11673-299	RINSE	0.07 kg	ORAL	OTC monograph not final	13 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	11673-299	RINSE	0.70 mg	ORAL	OTC monograph not final	13 sections
Alcohol Free Antiseptic	HUMAN OTC DRUG LABEL	1	11822-5761	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	12 sections
Alcohol Free Antiseptic	HUMAN OTC DRUG LABEL	1	11822-5761	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	12 sections
Mint	HUMAN OTC DRUG LABEL	1	21130-299	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	10 sections
Mint	HUMAN OTC DRUG LABEL	1	21130-299	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	10 sections
Roccos Old SchoolPeircing Armor	HUMAN OTC DRUG LABEL	1	24488-011	SPRAY	0.03 mL	TOPICAL	OTC monograph not final	11 sections
Killfire mouth freshener	HUMAN OTC DRUG LABEL	1	24765-134	SPRAY	0.05 g	ORAL	OTC monograph not final	8 sections
Killfire mouth freshener	HUMAN OTC DRUG LABEL	1	24765-134	SPRAY	0.05 g	ORAL	OTC monograph not final	8 sections
Alcohol Free Antiseptic	HUMAN OTC DRUG LABEL	1	30142-299	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	11 sections
Alcohol Free Antiseptic	HUMAN OTC DRUG LABEL	1	30142-299	MOUTHWASH	0.70 mg	ORAL	OTC monograph not final	11 sections
Multi-Action Antiseptic	HUMAN OTC DRUG LABEL	1	33992-0299	RINSE	0.70 mg	ORAL	OTC monograph not final	12 sections
Multi-Action Antiseptic	HUMAN OTC DRUG LABEL	1	33992-0299	RINSE	0.70 mg	ORAL	OTC monograph not final	12 sections
AssuredOral Health Fresh Mint	HUMAN OTC DRUG LABEL	1	33992-0320	RINSE	0.07 g	ORAL	OTC monograph not final	11 sections
Total Advanced Health Fresh Mint	HUMAN OTC DRUG LABEL	1	35000-390	RINSE	0.75 mg	DENTAL	OTC MONOGRAPH NOT FINAL	12 sections
Total Advanced Health Fresh Mint	HUMAN OTC DRUG LABEL	1	35000-390	RINSE	0.75 mg	DENTAL	OTC MONOGRAPH NOT FINAL	12 sections
Hello Peace Out Plaque peace out, plaque antigingivitis	HUMAN OTC DRUG LABEL	1	35000-683	MOUTHWASH	15 mg	DENTAL	OTC MONOGRAPH NOT FINAL	12 sections
Colgate Total Advanced Pro-Shield Peppermint Blast	HUMAN OTC DRUG LABEL	1	35000-720	RINSE	15 mg	DENTAL	OTC MONOGRAPH NOT FINAL	12 sections
Colgate Total Advanced Pro-Shield Peppermint Blast	HUMAN OTC DRUG LABEL	1	35000-720	RINSE	15 mg	DENTAL	OTC MONOGRAPH NOT FINAL	12 sections