cetylpyridinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3083 7773-52-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetylpyridinium
  • ceepryn
  • hexadecylpyridinium
  • cetylpyridinium chloride
Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.74
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.88
  • ALOGS: -7.72
  • ROTB: 15

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 177.80 56.50 36 1011 4641 50599436
Pulmonary toxicity 165.82 56.50 35 1012 5527 50598550
Neoplasm malignant 119.74 56.50 36 1011 23679 50580398
Joint injury 118.35 56.50 35 1012 21754 50582323
Hepatotoxicity 114.84 56.50 36 1011 27190 50576887
C-reactive protein abnormal 114.09 56.50 36 1011 27773 50576304
Therapy non-responder 96.28 56.50 37 1010 50985 50553092
Joint stiffness 90.99 56.50 31 1016 30277 50573800
Musculoskeletal pain 80.64 56.50 36 1011 72141 50531936
Musculoskeletal stiffness 66.34 56.50 38 1009 128443 50475634
Treatment failure 58.71 56.50 36 1011 137601 50466476

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 57.35 36.34 13 700 5309 64492710
Pulmonary toxicity 51.21 36.34 13 700 8548 64489471
Therapy non-responder 47.24 36.34 20 693 65879 64432140
Toxic anterior segment syndrome 43.38 36.34 9 704 2430 64495589
Neoplasm malignant 41.53 36.34 14 699 24674 64473345
Product preparation error 38.93 36.34 9 704 3996 64494023
Joint injury 38.55 36.34 13 700 22934 64475085

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05CA01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AJ03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA07 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA06 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:35195 surfactant
CHEBI has role CHEBI:48218 antiseptics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Local anesthesia indication 386761002
Mouth Irritation indication
Suppression of the Gag Reflex indication
Hypocupremia contraindication 19577007
Methemoglobinemia contraindication 38959009 DOID:10783
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Caspase-2 Enzyme EC50 4.68 CHEMBL
High affinity choline transporter 1 Transporter Ki 4.49 CHEMBL

External reference:

IDSource
4019671 VUID
N0000147763 NUI
D07666 KEGG_DRUG
6004-24-6 SECONDARY_CAS_RN
4019096 VANDF
4019671 VANDF
C0007906 UMLSCUI
CHEBI:32915 CHEBI
CHEMBL305906 ChEMBL_ID
CHEMBL2003538 ChEMBL_ID
DB11073 DRUGBANK_ID
CHEMBL34833 ChEMBL_ID
D002594 MESH_DESCRIPTOR_UI
2683 PUBCHEM_CID
CUB7JI0JV3 UNII
2286 RXNORM
4401 MMSL
73038 MMSL
003144 NDDF
11719000 SNOMEDCT_US
387043006 SNOMEDCT_US
395927000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oral-BAnti-Bacterial HUMAN OTC DRUG LABEL 1 0041-1420 LIQUID 500 ug DENTAL OTC monograph not final 13 sections
ParodontaxActive Gum Health Clear Mint HUMAN OTC DRUG LABEL 1 0135-0650 MOUTHWASH 0.70 mg ORAL OTC monograph not final 12 sections
ParodontaxActive Gum Health Mint HUMAN OTC DRUG LABEL 1 0135-0651 MOUTHWASH 70 mg ORAL OTC monograph not final 12 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0869-0299 RINSE 0.07 kg ORAL OTC monograph not final 11 sections
Orajle Anti-Bacterial Rinse for Bleeding Gums HUMAN OTC DRUG LABEL 1 10237-721 LIQUID 0.00 mL ORAL OTC monograph not final 6 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 RINSE 0.70 mg ORAL OTC monograph not final 13 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 RINSE 0.07 kg ORAL OTC monograph not final 13 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 11822-5761 MOUTHWASH 0.70 mg ORAL OTC monograph not final 12 sections
Mint HUMAN OTC DRUG LABEL 1 21130-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 10 sections
Roccos Old SchoolPeircing Armor HUMAN OTC DRUG LABEL 1 24488-011 SPRAY 0.03 mL TOPICAL OTC monograph not final 11 sections
Killfire mouth freshener HUMAN OTC DRUG LABEL 1 24765-134 SPRAY 0.05 g ORAL OTC monograph not final 8 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 30142-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 11 sections
Multi-Action Antiseptic HUMAN OTC DRUG LABEL 1 33992-0299 RINSE 0.70 mg ORAL OTC monograph not final 12 sections
AssuredOral Health Fresh Mint HUMAN OTC DRUG LABEL 1 33992-0320 RINSE 0.07 g ORAL OTC monograph not final 11 sections
Total Advanced Health Fresh Mint HUMAN OTC DRUG LABEL 1 35000-390 RINSE 0.75 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Total Advanced Pro-Shield Peppermint Blast HUMAN OTC DRUG LABEL 1 35000-720 RINSE 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Total Advanced Gum Health Mouthwash HUMAN OTC DRUG LABEL 1 35000-723 RINSE 0.75 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Total 12 Hr Pro-Shield Spearmint Surge HUMAN OTC DRUG LABEL 1 35000-731 RINSE 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Total Ultra Fresh HUMAN OTC DRUG LABEL 1 35000-735 RINSE 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Zero Healthy Gums HUMAN OTC DRUG LABEL 1 35000-880 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Zero Fresh Breath HUMAN OTC DRUG LABEL 1 35000-882 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Swish Mild Mint HUMAN OTC DRUG LABEL 1 35000-889 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Swish Refreshing Mint HUMAN OTC DRUG LABEL 1 35000-890 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Swish Invigorating Mint HUMAN OTC DRUG LABEL 1 35000-891 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Simply Fresh Mint HUMAN OTC DRUG LABEL 1 35000-892 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Antiseptic HUMAN OTC DRUG LABEL 1 36800-299 RINSE 0.70 mg ORAL OTC monograph not final 12 sections
FixodentGum Care HUMAN OTC DRUG LABEL 1 37000-169 RINSE 0.07 g ORAL OTC monograph not final 11 sections
Crest Pro-Health Multi-ProtectionRefreshing Clean Mint HUMAN OTC DRUG LABEL 1 37000-451 RINSE 0.01 g ORAL OTC monograph not final 11 sections
Crest Pro-Health HUMAN OTC DRUG LABEL 1 37000-452 RINSE 0.01 g ORAL OTC monograph not final 11 sections
Crest Pro-HealthIntense Clean Mint HUMAN OTC DRUG LABEL 1 37000-479 RINSE 0.05 g ORAL OTC monograph not final 11 sections