cetylpyridinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 3083 7773-52-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetylpyridinium
  • ceepryn
  • hexadecylpyridinium
  • cetylpyridinium chloride
Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.74
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.88
  • ALOGS: -7.72
  • ROTB: 15

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 326.60 52.39 70 1960 7671 63479321
Pulmonary toxicity 307.18 52.39 69 1961 9386 63477606
Neoplasm malignant 232.78 52.39 70 1960 29791 63457201
Joint injury 229.12 52.39 69 1961 29503 63457489
Hepatotoxicity 217.92 52.39 70 1960 36971 63450021
C-reactive protein abnormal 199.00 52.39 69 1961 46027 63440965
Therapy non-responder 168.90 52.39 70 1960 75831 63411161
Joint stiffness 162.72 52.39 58 1972 41811 63445181
Musculoskeletal pain 158.94 52.39 71 1959 92206 63394786
Musculoskeletal stiffness 115.08 52.39 72 1958 184546 63302446
Therapeutic product effect incomplete 110.03 52.39 61 1969 124995 63361997
Treatment failure 102.80 52.39 69 1961 198974 63288018
Infection 100.89 52.39 72 1958 229101 63257891
Drug hypersensitivity 89.67 52.39 76 1954 310611 63176381
Arthropathy 81.46 52.39 64 1966 234728 63252264
Pain in extremity 77.49 52.39 72 1958 331414 63155578
Joint swelling 76.25 52.39 71 1959 327595 63159397
Condition aggravated 67.52 52.39 73 1957 402144 63084848
Drug intolerance 64.36 52.39 63 1967 308598 63178394

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Conjunctival scar 37.15 34.76 5 272 134 34956520

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 129.57 31.08 30 1437 8079 79734842
Pulmonary toxicity 115.70 31.08 30 1437 12884 79730037
Neoplasm malignant 92.97 31.08 31 1436 31779 79711142
Joint injury 89.44 31.08 30 1437 31305 79711616
Joint stiffness 77.98 31.08 29 1438 40801 79702120
Therapy non-responder 76.05 31.08 36 1431 92269 79650652
Hepatotoxicity 74.98 31.08 30 1437 51322 79691599
C-reactive protein abnormal 73.20 31.08 29 1438 48338 79694583
Musculoskeletal pain 58.01 31.08 31 1436 102323 79640598
Toxic anterior segment syndrome 53.67 31.08 12 1455 2752 79740169
Conjunctival scar 45.31 31.08 7 1460 210 79742711
Musculoskeletal stiffness 44.99 31.08 32 1435 174976 79567945
Treatment failure 38.87 31.08 29 1438 170457 79572464
Drug hypersensitivity 35.58 31.08 35 1432 298881 79444040
Infection 33.89 31.08 31 1436 241681 79501240

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05CA01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AJ03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA07 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA06 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:35195 surfactant
CHEBI has role CHEBI:48218 antiseptics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Local anesthesia indication 386761002
Mouth Irritation indication
Suppression of the Gag Reflex indication
Hypocupremia contraindication 19577007
Methemoglobinemia contraindication 38959009 DOID:10783
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Caspase-2 Enzyme EC50 4.68 CHEMBL
High affinity choline transporter 1 Transporter Ki 4.49 CHEMBL

External reference:

IDSource
4019671 VUID
N0000147763 NUI
D07666 KEGG_DRUG
6004-24-6 SECONDARY_CAS_RN
4019096 VANDF
4019671 VANDF
C0007906 UMLSCUI
CHEBI:32915 CHEBI
CHEMBL305906 ChEMBL_ID
DB11073 DRUGBANK_ID
CHEMBL2003538 ChEMBL_ID
CHEMBL34833 ChEMBL_ID
D002594 MESH_DESCRIPTOR_UI
2683 PUBCHEM_CID
CUB7JI0JV3 UNII
2286 RXNORM
4401 MMSL
73038 MMSL
003144 NDDF
11719000 SNOMEDCT_US
387043006 SNOMEDCT_US
395927000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oral-BAnti-Bacterial HUMAN OTC DRUG LABEL 1 0041-1420 LIQUID 500 ug DENTAL OTC monograph not final 26 sections
ParodontaxActive Gum Health Clear Mint HUMAN OTC DRUG LABEL 1 0135-0650 MOUTHWASH 0.70 mg ORAL OTC monograph not final 12 sections
ParodontaxActive Gum Health Clear Mint HUMAN OTC DRUG LABEL 1 0135-0650 MOUTHWASH 0.70 mg ORAL OTC monograph not final 12 sections
ParodontaxActive Gum Health Mint HUMAN OTC DRUG LABEL 1 0135-0651 MOUTHWASH 70 mg ORAL OTC monograph not final 12 sections
ParodontaxActive Gum Health Mint HUMAN OTC DRUG LABEL 1 0135-0651 MOUTHWASH 70 mg ORAL OTC monograph not final 12 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0869-0299 RINSE 0.07 kg ORAL OTC monograph not final 11 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0869-0299 RINSE 0.07 kg ORAL OTC monograph not final 11 sections
TheraBreath Healthy Gums HUMAN OTC DRUG LABEL 1 10237-258 RINSE 0.01 mg ORAL OTC MONOGRAPH NOT FINAL 11 sections
Therabreath Plaque Control HUMAN OTC DRUG LABEL 1 10237-259 RINSE 0.02 mg ORAL OTC MONOGRAPH NOT FINAL 11 sections
Orajle Anti-Bacterial Rinse for Bleeding Gums HUMAN OTC DRUG LABEL 1 10237-721 LIQUID 0.00 mL ORAL OTC monograph not final 12 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 RINSE 0.70 mg ORAL OTC monograph not final 13 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 RINSE 0.07 kg ORAL OTC monograph not final 13 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 RINSE 0.70 mg ORAL OTC monograph not final 13 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 11822-5761 MOUTHWASH 0.70 mg ORAL OTC monograph not final 12 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 11822-5761 MOUTHWASH 0.70 mg ORAL OTC monograph not final 12 sections
Mint HUMAN OTC DRUG LABEL 1 21130-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 10 sections
Mint HUMAN OTC DRUG LABEL 1 21130-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 10 sections
Roccos Old SchoolPeircing Armor HUMAN OTC DRUG LABEL 1 24488-011 SPRAY 0.03 mL TOPICAL OTC monograph not final 11 sections
Killfire mouth freshener HUMAN OTC DRUG LABEL 1 24765-134 SPRAY 0.05 g ORAL OTC monograph not final 8 sections
Killfire mouth freshener HUMAN OTC DRUG LABEL 1 24765-134 SPRAY 0.05 g ORAL OTC monograph not final 8 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 30142-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 11 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 30142-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 11 sections
Multi-Action Antiseptic HUMAN OTC DRUG LABEL 1 33992-0299 RINSE 0.70 mg ORAL OTC monograph not final 12 sections
Multi-Action Antiseptic HUMAN OTC DRUG LABEL 1 33992-0299 RINSE 0.70 mg ORAL OTC monograph not final 12 sections
AssuredOral Health Fresh Mint HUMAN OTC DRUG LABEL 1 33992-0320 RINSE 0.07 g ORAL OTC monograph not final 11 sections
Total Advanced Health Fresh Mint HUMAN OTC DRUG LABEL 1 35000-390 RINSE 0.75 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Total Advanced Health Fresh Mint HUMAN OTC DRUG LABEL 1 35000-390 RINSE 0.75 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Hello Peace Out Plaque peace out, plaque antigingivitis HUMAN OTC DRUG LABEL 1 35000-683 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Total Advanced Pro-Shield Peppermint Blast HUMAN OTC DRUG LABEL 1 35000-720 RINSE 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections
Colgate Total Advanced Pro-Shield Peppermint Blast HUMAN OTC DRUG LABEL 1 35000-720 RINSE 15 mg DENTAL OTC MONOGRAPH NOT FINAL 12 sections