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bergapten 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3021 | 484-20-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 | 59 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,MAP2K3,MAP2K6,MAP3K14,MAPK12,MAPK7,MAPK8,MARK4,PDK4,PRKDC,SIK2,STK33,TEK,TTK | 22 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D05BA03 | DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR SYSTEMIC USE Psoralens for systemic use |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
| MeSH PA | D017319 | Photosensitizing Agents |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| CHEBI has role | CHEBI:50748 | antipsoriatic |
| CHEBI has role | CHEBI:62868 | hepatoprotective agent |
| CHEBI has role | CHEBI:76924 | plant metabolite |
Related Drugs by ATC class:
D05BA Psoralens for systemic use 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] A | Enzyme | IC50 | 4.86 | CHEMBL | |||||
| Cytochrome P450 1A1 | Enzyme | Ki | 7.22 | CHEMBL | |||||
| Taste receptor type 2 member 10 | GPCR | AGONIST | EC50 | 5.55 | IUPHAR | ||||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Kinase | AC50 | 5.83 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07521 | KEGG_DRUG |
| C0049289 | UMLSCUI |
| CHEBI:18293 | CHEBI |
| CHEMBL24171 | ChEMBL_ID |
| DB12216 | DRUGBANK_ID |
| 2355 | PUBCHEM_CID |
| 12431 | IUPHAR_LIGAND_ID |
| 4FVK84C92X | UNII |
| 15842 | RXNORM |
| 005216 | NDDF |
| 429146002 | SNOMEDCT_US |
| 441498004 | SNOMEDCT_US |
| D000078223 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None