trioxsalen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2759 3902-71-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trioxsalen
  • trimethylpsoralen
  • trioxysalen
  • trisoralen
Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
  • Molecular weight: 228.25
  • Formula: C14H12O3
  • CLOGP: 3.47
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 39.44
  • ALOGS: -3.56
  • ROTB: 0

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 24, 1964 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D05AD01 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Psoralens for topical use
ATC D05BA01 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR SYSTEMIC USE
Psoralens for systemic use
FDA CS M0017973 Psoralens
MeSH PA D003879 Dermatologic Agents
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
FDA EPC N0000175879 Psoralen
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:50177 dermatologic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vitiligo indication 56727007 DOID:12306
Photosensitivity indication 90128006
Skin Pigmentation Enhancement indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adenosine receptor A2a GPCR Ki 6.13 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.91 DRUG MATRIX
Amine oxidase [flavin-containing] A Enzyme IC50 6.08 DRUG MATRIX

External reference:

IDSource
4018884 VUID
N0000147178 NUI
D01034 KEGG_DRUG
4018884 VANDF
C0041086 UMLSCUI
CHEBI:28329 CHEBI
CHEMBL1475 ChEMBL_ID
DB04571 DRUGBANK_ID
D014307 MESH_DESCRIPTOR_UI
5585 PUBCHEM_CID
2064 INN_ID
Y6UY8OV51T UNII
10844 RXNORM
3061 MMSL
5637 MMSL
d01436 MMSL
002021 NDDF

Pharmaceutical products:

None