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methoxsalen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	30	298-81-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: 8-MOP methoxsalene 8-Methoxypsoralen 8-Methoxypsoralene deltapsoralen meladinin meladinine meladoxen meloxine methoxsalen oxsoralen xanthotoxin xanthotoxine	A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation. Molecular weight: 216.19 Formula: C12H8O4 CLOGP: 2.31 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 48.67 ALOGS: -3.12 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

8-MOP
methoxsalene
8-Methoxypsoralen
8-Methoxypsoralene
deltapsoralen
meladinin
meladinine
meladoxen
meloxine
methoxsalen
oxsoralen
xanthotoxin
xanthotoxine

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.

Molecular weight: 216.19
Formula: C12H8O4
CLOGP: 2.31
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 48.67
ALOGS: -3.12
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

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Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Hosey CM, Chan R, Benet LZ
CL (Clearance)	12 mL/min/kg	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	0.61 L/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.09 %	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.02 mg/mL	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
Dec. 3, 1954	FDA	VALEANT PHARM INTL

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product use in unapproved indication	284.21	48.19	77	215	179003	63309727

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product use in unapproved indication	275.31	40.76	82	276	117417	34839156

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product use in unapproved indication	449.89	39.75	133	470	250226	79493559
Pulmonary embolism	47.75	39.75	24	579	171630	79572155

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D05AD02	DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR TOPICAL USE Psoralens for topical use
ATC	D05BA02	DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR SYSTEMIC USE Psoralens for systemic use
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:47868	photosensitising agent
CHEBI has role	CHEBI:50177	dermatologic agent
CHEBI has role	CHEBI:50684	cross-linking reagents
CHEBI has role	CHEBI:76924	plant metabolites
FDA CS	M0017973	Psoralens
FDA EPC	N0000175879	Psoralen
FDA EPC	N0000175984	Photoactivated Radical Generator

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Vitiligo	indication	56727007	DOID:12306
Primary cutaneous T-cell lymphoma	indication	400122007
Severe Recalcitrant Psoriasis	indication
Lichen planus	off-label use	4776004	DOID:9201
Alopecia areata	off-label use	68225006	DOID:986
Mycosis fungoides	off-label use	118618005
Albinism	contraindication	15890002
Aphakia	contraindication	24010005
Xeroderma pigmentosum	contraindication	44600005	DOID:0050427
Erythropoietic protoporphyria	contraindication	51022005	DOID:13270

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.12	CHEMBL
Cytochrome P450 1A2	Enzyme	P05177	CP1A2_HUMAN		IC50	7.40	DRUG MATRIX
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN		IC50	4.07	CHEMBL
Taste receptor type 2 member 20	GPCR	P59543	T2R20_HUMAN	AGONIST	EC50	4.92	IUPHAR
Polyphenol oxidase 2	Enzyme		PPO2_AGABI		EC50	4.83	CHEMBL

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External reference:

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ID	Source
8MO	PDB_CHEM_ID
002018	NDDF
11350	MMSL
12457	IUPHAR_LIGAND_ID
1906	MMSL
227713	RXNORM
400526000	SNOMEDCT_US
4018889	VANDF
41062004	SNOMEDCT_US
4114	PUBCHEM_CID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Methoxsalen	HUMAN PRESCRIPTION DRUG LABEL	1	64380-752	CAPSULE, LIQUID FILLED	10 mg	ORAL	ANDA	23 sections
UVADEX	HUMAN PRESCRIPTION DRUG LABEL	1	64067-216	INJECTION, SOLUTION	20 ug	EXTRACORPOREAL	NDA	27 sections

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