benzethonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 3018 121-54-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzethonium
  • benzethionium chloride
  • benzethonium chloride
  • benzetonium chloride
Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
  • Molecular weight: 412.64
  • Formula: C27H42NO2
  • CLOGP: 4.29
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 18.46
  • ALOGS: -7.78
  • ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 6791.66 20.60 2281 17831 143392 63325518
Toxicity to various agents 4103.71 20.60 1833 18279 245417 63223493
Drug abuse 2179.48 20.60 828 19284 71690 63397220
Cardio-respiratory arrest 1303.57 20.60 543 19569 59416 63409494
Intentional overdose 1189.42 20.60 542 19570 73610 63395300
Overdose 872.32 20.60 508 19604 114570 63354340
Suicide attempt 739.24 20.60 368 19744 60550 63408360
Alcohol interaction 508.38 20.60 124 19988 2285 63466625
Suspected suicide 456.03 20.60 141 19971 6427 63462483
Respiratory arrest 368.39 20.60 188 19924 32457 63436453
Intentional product misuse 367.86 20.60 233 19879 60684 63408226
Cardiac arrest 349.13 20.60 265 19847 92280 63376630
Death 291.95 20.60 465 19647 373916 63094994
Exposure to toxic agent 281.39 20.60 94 20018 5493 63463417
Alcohol poisoning 267.72 20.60 71 20041 1848 63467062
Alcohol use 220.53 20.60 62 20050 2017 63466893
Coma 211.48 20.60 170 19942 64194 63404716
Somnolence 186.41 20.60 255 19857 178430 63290480
Alcohol abuse 183.00 20.60 54 20058 2092 63466818
Drug ineffective 158.69 20.60 67 20045 1044698 62424212
Agitation 126.39 20.60 123 19989 59634 63409276
Pain 123.04 20.60 41 20071 740587 62728323
Poisoning 118.07 20.60 66 20046 13634 63455276
Poisoning deliberate 116.05 20.60 61 20051 11157 63457753
Mydriasis 115.19 20.60 62 20050 11894 63457016
Fatigue 108.23 20.60 75 20037 887953 62580957
Diarrhoea 108.08 20.60 46 20066 715320 62753590
Loss of consciousness 104.49 20.60 156 19956 117965 63350945
Arthralgia 100.88 20.60 28 20084 569682 62899228
Alcoholism 97.16 20.60 32 20080 1786 63467124
Substance abuse 95.58 20.60 41 20071 4766 63464144
Seizure 89.67 20.60 155 19957 132479 63336431
Myocarditis 86.96 20.60 49 20063 10276 63458634
Blood alcohol increased 85.61 20.60 23 20089 629 63468281
Postmortem blood drug level abnormal 83.57 20.60 20 20092 338 63468572
Drug dependence 81.03 20.60 65 20047 24418 63444492
Intentional self-injury 78.29 20.60 65 20047 25622 63443288
Rash 75.56 20.60 42 20070 560829 62908081
Victim of sexual abuse 75.28 20.60 21 20091 663 63468247
Alopecia 73.46 20.60 10 20102 337526 63131384
Joint swelling 73.02 20.60 9 20103 327657 63141253
Abdominal discomfort 71.05 20.60 9 20103 320876 63148034
Suicidal ideation 70.89 20.60 93 20019 62328 63406582
Chemical submission 67.10 20.60 16 20096 266 63468644
Drug use disorder 65.89 20.60 32 20080 4952 63463958
Drug interaction 63.84 20.60 188 19924 228943 63239967
Pyrexia 63.65 20.60 35 20077 470443 62998467
Dyspnoea 63.25 20.60 70 20042 661243 62807667
Drug intolerance 62.93 20.60 11 20101 308650 63160260
Aggression 60.51 20.60 54 20058 23444 63445466
Condition aggravated 60.35 20.60 26 20086 402191 63066719
Off label use 59.58 20.60 76 20036 674386 62794524
Depressed level of consciousness 59.20 20.60 85 20027 61993 63406917
Broncholithiasis 58.37 20.60 14 20098 239 63468671
Swelling 57.94 20.60 9 20103 275369 63193541
Asthenia 55.66 20.60 26 20086 383578 63085332
Drug withdrawal syndrome 55.63 20.60 55 20057 27139 63441771
Congestive hepatopathy 54.91 20.60 24 20088 2918 63465992
Lymph node calcification 54.59 20.60 14 20098 318 63468592
Pneumonia 52.26 20.60 41 20071 456726 63012184
Somnambulism 51.31 20.60 28 20084 5515 63463395
Arthropathy 50.95 20.60 7 20105 234785 63234125
Metabolic acidosis 50.93 20.60 67 20045 45002 63423908
Pain in extremity 50.38 20.60 21 20091 331465 63137445
Drug hypersensitivity 50.00 20.60 18 20094 310669 63158241
Electrocardiogram ST segment elevation 48.29 20.60 24 20088 3903 63465007
Nasopharyngitis 47.76 20.60 11 20101 254246 63214664
Synovitis 47.34 20.60 3 20109 186915 63281995
Anaemia 47.22 20.60 17 20095 293413 63175497
Product administration interrupted 46.35 20.60 25 20087 4811 63464099
Tachycardia 46.14 20.60 110 20002 118046 63350864
Systemic lupus erythematosus 45.87 20.60 6 20106 208912 63259998
Pruritus 45.86 20.60 29 20083 361424 63107486
Asphyxia 45.82 20.60 27 20085 6154 63462756
Rheumatoid arthritis 45.70 20.60 12 20100 253807 63215103
Headache 43.82 20.60 84 20028 633157 62835753
Peripheral swelling 43.48 20.60 15 20097 265927 63202983
Electrocardiogram QT prolonged 43.39 20.60 72 20040 59458 63409452
Neutropenia 40.99 20.60 4 20108 175001 63293909
Substance use disorder 40.34 20.60 10 20102 197 63468713
Sopor 40.18 20.60 42 20070 22122 63446788
Victim of chemical submission 39.36 20.60 12 20100 520 63468390
Electrocardiogram QRS complex prolonged 39.00 20.60 24 20088 5914 63462996
Weight increased 38.85 20.60 17 20095 260775 63208135
Product dose omission issue 38.67 20.60 13 20099 234300 63234610
Liver injury 38.60 20.60 69 20043 60451 63408459
Sinusitis 38.42 20.60 12 20100 226641 63242269
Amnesia 37.56 20.60 65 20047 55520 63413390
Protein C increased 34.90 20.60 8 20104 111 63468799
Hepatic failure 34.24 20.60 49 20063 35607 63433303
Homicide 34.19 20.60 10 20102 375 63468535
Discomfort 34.00 20.60 6 20106 167368 63301542
Urinary tract infection 33.87 20.60 21 20091 264663 63204247
Bronchial wall thickening 33.85 20.60 14 20098 1485 63467425
Hepatic encephalopathy 33.23 20.60 28 20084 11254 63457656
Stomatitis 32.93 20.60 3 20109 138722 63330188
Musculoskeletal stiffness 32.70 20.60 9 20103 184609 63284301
Abnormal behaviour 32.56 20.60 37 20075 21389 63447521
Cough 32.53 20.60 27 20085 292716 63176194
Hypersensitivity 32.51 20.60 27 20085 292658 63176252
Constipation 31.43 20.60 16 20096 224927 63243983
Lichen nitidus 31.25 20.60 7 20105 87 63468823
Infection 31.00 20.60 17 20095 229156 63239754
Substance dependence 30.62 20.60 8 20104 196 63468714
Accidental death 30.14 20.60 14 20098 1962 63466948
Treatment failure 29.59 20.60 13 20099 199030 63269880
Induced abortion failed 28.94 20.60 8 20104 244 63468666
Wound 28.84 20.60 8 20104 163255 63305655
Pericarditis 28.34 20.60 4 20108 131575 63337335
Ventricular tachycardia 27.84 20.60 33 20079 19946 63448964
Sinus tachycardia 27.29 20.60 36 20076 24232 63444678
Congenital umbilical hernia 27.23 20.60 8 20104 305 63468605
Hypotension 27.05 20.60 163 19949 272441 63196469
Shock 26.68 20.60 35 20077 23428 63445482
Lower respiratory tract infection 26.32 20.60 5 20107 132302 63336608
Malaise 26.31 20.60 58 20054 415896 63053014
Arthritis 26.24 20.60 3 20109 115918 63352992
Aspiration 26.09 20.60 24 20088 10827 63458083
Disinhibition 26.05 20.60 10 20102 873 63468037
Disease progression 25.82 20.60 4 20108 122754 63346156
Nausea 25.82 20.60 162 19950 854309 62614601
Sexual abuse 25.21 20.60 7 20105 217 63468693
Road traffic accident 24.95 20.60 43 20069 36589 63432321
Respiratory depression 24.87 20.60 26 20086 13689 63455221
Febrile neutropenia 24.60 20.60 4 20108 118445 63350465
Encephalopathy 24.58 20.60 44 20068 38576 63430334
Hyperlipasaemia 24.39 20.60 9 20103 704 63468206
Toxicologic test abnormal 24.30 20.60 9 20103 712 63468198
White blood cell count decreased 24.22 20.60 7 20105 139097 63329813
Blood ethanol increased 24.12 20.60 6 20106 120 63468790
Areflexia 24.11 20.60 14 20098 3104 63465806
Thrombocytopenia 23.88 20.60 9 20103 151148 63317762
Blister 23.60 20.60 6 20106 129808 63339102
Alcoholic 23.60 20.60 5 20107 47 63468863
Decreased appetite 23.43 20.60 27 20085 251025 63217885
Postmortem blood drug level 23.36 20.60 6 20106 137 63468773
Dizziness 23.24 20.60 65 20047 429860 63039050
Drug level increased 22.94 20.60 32 20080 22704 63446206
Euphoric mood 22.92 20.60 16 20096 4871 63464039
Sepsis 22.75 20.60 10 20102 153113 63315797
Impaired healing 22.36 20.60 3 20109 102539 63366371
Accidental overdose 22.33 20.60 32 20080 23277 63445633
Drug screen positive 22.15 20.60 14 20098 3615 63465295
Unresponsive to stimuli 22.13 20.60 39 20073 33777 63435133
Back pain 21.96 20.60 31 20081 264114 63204796
Injection site pain 21.75 20.60 7 20105 129793 63339117
Opiates positive 21.46 20.60 7 20105 379 63468531
Amphetamines positive 21.31 20.60 6 20106 196 63468714
Loss of personal independence in daily activities 20.85 20.60 3 20109 97287 63371623
Haemoglobin decreased 20.84 20.60 10 20102 145475 63323435
Cardiogenic shock 20.78 20.60 27 20085 17905 63451005
General physical health deterioration 20.65 20.60 20 20092 201382 63267528
Renal tubular necrosis 20.62 20.60 22 20090 11856 63457054
Weight decreased 20.61 20.60 35 20077 276763 63192147

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5573.12 23.43 2193 21974 96903 34835861
Completed suicide 4071.82 23.43 1752 22415 96416 34836348
Toxicity to various agents 3662.83 23.43 2040 22127 198322 34734442
Cardio-respiratory arrest 870.10 23.43 516 23651 54757 34878007
Intentional overdose 794.16 23.43 448 23719 43226 34889538
Overdose 626.17 23.43 511 23656 90548 34842216
Alcohol abuse 554.95 23.43 182 23985 4508 34928256
Intentional product misuse 530.91 23.43 352 23815 45259 34887505
Alcohol interaction 520.72 23.43 155 24012 2758 34930006
Suicide attempt 467.51 23.43 307 23860 38809 34893955
Suspected suicide 392.86 23.43 141 24026 4607 34928157
Drug dependence 356.52 23.43 217 23950 24000 34908764
Alcohol poisoning 336.48 23.43 117 24050 3476 34929288
Substance abuse 288.81 23.43 129 24038 7512 34925252
Coma 247.20 23.43 224 23943 45454 34887310
Exposure to toxic agent 216.05 23.43 85 24082 3590 34929174
Asphyxia 210.14 23.43 100 24067 6735 34926029
Respiratory depression 204.80 23.43 132 24035 16113 34916651
Aggression 198.92 23.43 185 23982 38779 34893985
Respiratory arrest 195.37 23.43 159 24008 27884 34904880
Poisoning deliberate 176.89 23.43 93 24074 7751 34925013
Alcohol use 172.28 23.43 70 24097 3218 34929546
Diarrhoea 143.27 23.43 46 24121 389866 34542898
Fractional exhaled nitric oxide increased 127.96 23.43 42 24125 1040 34931724
Poisoning 124.42 23.43 87 24080 12139 34920625
Pneumonia 122.56 23.43 49 24118 362578 34570186
Fatigue 114.40 23.43 57 24110 370596 34562168
Blood alcohol increased 113.90 23.43 36 24131 787 34931977
Drug ineffective 112.61 23.43 91 24076 456660 34476104
Incorrect route of product administration 107.20 23.43 86 24081 14759 34918005
Pyrexia 106.09 23.43 49 24118 332964 34599800
Cardiac arrest 105.48 23.43 216 23951 95943 34836821
Substance use disorder 103.37 23.43 33 24134 746 34932018
Anaemia 99.98 23.43 20 24147 233315 34699449
Intentional product use issue 99.49 23.43 161 24006 59655 34873109
Death 97.96 23.43 536 23631 397513 34535251
Plantar fasciitis 97.16 23.43 41 24126 2075 34930689
Drug use disorder 92.51 23.43 49 24118 4142 34928622
Neutropenia 91.42 23.43 4 24163 156774 34775990
Sensation of foreign body 89.46 23.43 42 24125 2741 34930023
Myoglobin blood increased 89.16 23.43 43 24124 2980 34929784
Depressed level of consciousness 87.70 23.43 127 24040 42714 34890050
Drug withdrawal syndrome 87.57 23.43 87 24080 19747 34913017
Miosis 83.62 23.43 62 24105 9473 34923291
Suicidal ideation 83.07 23.43 120 24047 40268 34892496
Off label use 82.18 23.43 102 24065 419422 34513342
Rash 80.32 23.43 27 24140 222725 34710039
Prescription drug used without a prescription 80.19 23.43 36 24131 2118 34930646
Intentional self-injury 75.28 23.43 68 24099 13703 34919061
Agitation 73.88 23.43 138 24029 57261 34875503
Mydriasis 67.85 23.43 49 24118 7188 34925576
Alcohol withdrawal syndrome 65.59 23.43 28 24139 1458 34931306
Disease progression 62.18 23.43 3 24164 108074 34824690
Pain 62.18 23.43 32 24135 204643 34728121
Brain natriuretic peptide increased 61.63 23.43 42 24125 5617 34927147
Accidental death 60.76 23.43 31 24136 2425 34930339
Constipation 60.17 23.43 11 24156 136971 34795793
Nausea 60.02 23.43 89 24078 339819 34592945
Drug interaction 59.87 23.43 311 23856 225635 34707129
Sepsis 58.60 23.43 21 24146 166540 34766224
Asthenia 56.38 23.43 52 24115 245199 34687565
Arthralgia 55.61 23.43 24 24143 170017 34762747
Medication error 55.55 23.43 78 24089 25487 34907277
Alcoholism 55.27 23.43 31 24136 2934 34929830
Platelet count decreased 53.91 23.43 9 24158 119708 34813056
Secretion discharge 53.13 23.43 39 24128 5866 34926898
Dyspnoea 51.90 23.43 115 24052 376667 34556097
Pain in extremity 51.75 23.43 12 24155 126501 34806263
Alcohol intolerance 51.48 23.43 17 24150 429 34932335
White blood cell count decreased 50.85 23.43 4 24163 95441 34837323
Haemoglobin decreased 50.31 23.43 11 24156 120761 34812003
Road traffic accident 49.97 23.43 61 24106 17389 34915375
Drug screen positive 49.56 23.43 32 24135 3911 34928853
Decreased appetite 49.06 23.43 27 24140 166365 34766399
General physical health deterioration 48.95 23.43 14 24153 128255 34804509
Withdrawal syndrome 48.37 23.43 51 24116 12404 34920360
Pancytopenia 47.98 23.43 5 24162 95152 34837612
Amnesia 47.56 23.43 74 24093 26489 34906275
Tachycardia 46.95 23.43 147 24020 84625 34848139
Sopor 45.90 23.43 49 24118 12087 34920677
Infection 45.27 23.43 5 24162 90910 34841854
Ex-drug abuser 44.81 23.43 12 24155 142 34932622
Loss of consciousness 44.54 23.43 142 24025 82525 34850239
Product dose omission issue 43.98 23.43 14 24153 119697 34813067
Malignant neoplasm progression 43.44 23.43 5 24162 88041 34844723
Metabolic acidosis 43.02 23.43 94 24073 43586 34889178
Back pain 41.72 23.43 16 24151 121773 34810991
Weight decreased 40.92 23.43 37 24130 176264 34756500
Exostosis 39.82 23.43 30 24137 4693 34928071
Cardiac failure congestive 38.06 23.43 6 24161 83264 34849500
Neuropathy peripheral 38.05 23.43 6 24161 83257 34849507
Oedema peripheral 37.44 23.43 18 24149 119794 34812970
Thrombocytopenia 37.21 23.43 32 24135 156215 34776549
Urinary tract infection 36.37 23.43 7 24160 84074 34848690
Obstructive airways disorder 36.25 23.43 49 24118 15445 34917319
Peripheral swelling 36.17 23.43 5 24162 76536 34856228
Opiates positive 36.12 23.43 14 24153 567 34932197
Hepatic fibrosis 36.06 23.43 28 24139 4579 34928185
Somnolence 35.85 23.43 162 24005 110954 34821810
Drug abuser 35.31 23.43 26 24141 3928 34928836
Impaired driving ability 34.65 23.43 22 24145 2611 34930153
Brain oedema 34.31 23.43 45 24122 13776 34918988
Interstitial lung disease 34.04 23.43 3 24164 65279 34867485
Pulmonary oedema 33.61 23.43 90 24077 47439 34885325
Cerebrovascular accident 32.82 23.43 9 24158 84802 34847962
Abdominal pain 32.70 23.43 39 24128 163579 34769185
Homicide 32.60 23.43 15 24152 934 34931830
COVID-19 32.41 23.43 7 24160 77543 34855221
Dizziness 32.26 23.43 64 24103 218457 34714307
Choroiditis 32.00 23.43 16 24151 1199 34931565
Dehydration 31.70 23.43 26 24141 129943 34802821
Foetal alcohol syndrome 31.58 23.43 9 24158 136 34932628
Myocardial infarction 31.07 23.43 23 24144 121062 34811702
Septic shock 31.02 23.43 6 24161 71828 34860936
Drug intolerance 30.36 23.43 3 24164 59567 34873197
Physical assault 29.92 23.43 15 24152 1130 34931634
Cardiac failure 29.60 23.43 13 24154 91235 34841529
Pleural effusion 29.13 23.43 10 24157 81536 34851228
Dysarthria 28.89 23.43 70 24097 34712 34898052
Blood ethanol 28.12 23.43 8 24159 120 34932644
Malaise 26.92 23.43 55 24112 185770 34746994
Myocardial fibrosis 26.43 23.43 14 24153 1183 34931581
Behaviour disorder 26.35 23.43 24 24143 4886 34927878
Muscular weakness 25.93 23.43 9 24158 72888 34859876
Pulmonary embolism 25.79 23.43 15 24152 89731 34843033
Blood creatinine increased 25.74 23.43 17 24150 94959 34837805
Unresponsive to stimuli 25.64 23.43 58 24109 27511 34905253
Sensorimotor disorder 25.19 23.43 10 24157 432 34932332
Gun shot wound 24.36 23.43 13 24154 1115 34931649
Pruritus 24.17 23.43 38 24129 141943 34790821
Dextrocardia 24.02 23.43 7 24160 115 34932649
Suicidal behaviour 23.51 23.43 14 24153 1483 34931281
Weight increased 23.44 23.43 18 24149 93015 34839749

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 10306.78 19.11 3983 34752 241784 79463869
Drug abuse 7761.82 19.11 2908 35827 159783 79545870
Toxicity to various agents 7596.08 19.11 3773 34962 417767 79287886
Cardio-respiratory arrest 2151.02 19.11 1048 37687 107462 79598191
Intentional overdose 1638.74 19.11 866 37869 105094 79600559
Overdose 1250.06 19.11 889 37846 183317 79522336
Alcohol interaction 876.24 19.11 241 38494 4633 79701020
Intentional product misuse 864.02 19.11 551 38184 94614 79611039
Suspected suicide 778.07 19.11 263 38472 10313 79695340
Suicide attempt 764.63 19.11 485 38250 82447 79623206
Alcohol abuse 572.71 19.11 177 38558 5186 79700467
Respiratory arrest 541.17 19.11 341 38394 57209 79648444
Alcohol poisoning 518.55 19.11 160 38575 4661 79700992
Death 489.50 19.11 935 37800 565579 79140074
Exposure to toxic agent 479.83 19.11 177 38558 8981 79696672
Coma 427.06 19.11 369 38366 100280 79605373
Drug dependence 417.15 19.11 255 38480 40514 79665139
Cardiac arrest 409.85 19.11 460 38275 171636 79534017
Alcohol use 327.31 19.11 113 38622 4718 79700935
Substance abuse 325.42 19.11 139 38596 10387 79695266
Poisoning deliberate 279.01 19.11 150 38585 18678 79686975
Drug ineffective 271.77 19.11 94 38641 1080819 78624834
Diarrhoea 230.85 19.11 71 38664 880418 78825235
Asphyxia 221.57 19.11 110 38625 11610 79694043
Poisoning 220.59 19.11 143 38592 25129 79680524
Aggression 216.24 19.11 187 38548 50771 79654882
Fatigue 202.45 19.11 100 38635 929627 78776026
Pain 191.15 19.11 53 38682 703749 79001904
Respiratory depression 187.95 19.11 134 38601 27496 79678157
Agitation 178.73 19.11 231 38504 99484 79606169
Blood alcohol increased 178.23 19.11 52 38683 1243 79704410
Arthralgia 175.23 19.11 33 38702 571770 79133883
Off label use 154.46 19.11 129 38606 907086 78798567
Mydriasis 151.92 19.11 99 38636 17544 79688109
Pyrexia 150.53 19.11 71 38664 678638 79027015
Drug use disorder 148.30 19.11 76 38659 8575 79697078
Rash 140.21 19.11 53 38682 578305 79127348
Substance use disorder 139.48 19.11 40 38695 898 79704755
Pneumonia 138.98 19.11 74 38661 660172 79045481
Dyspnoea 137.23 19.11 129 38606 856896 78848757
Somnolence 135.68 19.11 334 38401 238647 79467006
Depressed level of consciousness 135.66 19.11 199 38536 96453 79609200
Intentional self-injury 125.56 19.11 113 38622 32306 79673347
Incorrect route of product administration 124.09 19.11 116 38619 34813 79670840
Anaemia 119.70 19.11 34 38701 444981 79260672
Nausea 110.48 19.11 185 38550 957011 78748642
Joint swelling 109.52 19.11 8 38727 288638 79417015
Neutropenia 109.09 19.11 8 38727 287702 79417951
Loss of consciousness 108.57 19.11 247 38488 167696 79537957
Miosis 108.34 19.11 77 38658 15712 79689941
Alcoholism 98.27 19.11 44 38691 3679 79701974
Drug interaction 97.92 19.11 430 38305 414753 79290900
Pain in extremity 97.72 19.11 28 38707 364510 79341143
Metabolic acidosis 97.60 19.11 157 38578 82372 79623281
Febrile neutropenia 95.02 19.11 4 38731 230995 79474658
Infusion related reaction 94.66 19.11 4 38731 230233 79475420
Suicidal ideation 92.70 19.11 147 38588 76193 79629460
Accidental death 92.30 19.11 44 38691 4247 79701406
Asthenia 91.54 19.11 69 38666 511620 79194033
Postmortem blood drug level abnormal 88.85 19.11 26 38709 628 79705025
Intentional product use issue 88.79 19.11 215 38520 151897 79553756
Cough 88.12 19.11 34 38701 366755 79338898
Drug intolerance 88.04 19.11 12 38723 264107 79441546
Nasopharyngitis 85.90 19.11 11 38724 253870 79451783
Abdominal discomfort 79.86 19.11 13 38722 250714 79454939
Prescription drug used without a prescription 79.16 19.11 39 38696 4046 79701607
Constipation 79.11 19.11 20 38715 283030 79422623
Pruritus 78.90 19.11 47 38688 394601 79311052
Alopecia 78.32 19.11 10 38725 231345 79474308
Headache 77.44 19.11 124 38611 653648 79052005
Peripheral swelling 77.41 19.11 18 38717 269599 79436054
Tachycardia 77.08 19.11 225 38510 177543 79528110
Condition aggravated 77.00 19.11 78 38657 501046 79204607
Urinary tract infection 75.56 19.11 20 38715 274492 79431161
Electrocardiogram QRS complex prolonged 72.41 19.11 52 38683 10781 79694872
Drug withdrawal syndrome 71.03 19.11 86 38649 34632 79671021
Arthropathy 69.84 19.11 4 38731 177107 79528546
Drug hypersensitivity 69.66 19.11 29 38706 298887 79406766
Weight increased 69.49 19.11 24 38711 277362 79428291
General physical health deterioration 68.63 19.11 24 38711 275214 79430439
Rheumatoid arthritis 68.22 19.11 10 38725 208460 79497193
Alcohol withdrawal syndrome 66.95 19.11 28 38707 1983 79703670
Product dose omission issue 66.32 19.11 19 38716 247518 79458135
Disease progression 64.80 19.11 7 38728 184355 79521298
Weight decreased 64.62 19.11 47 38688 355151 79350502
White blood cell count decreased 64.06 19.11 8 38727 188280 79517373
Decreased appetite 64.01 19.11 44 38691 342374 79363279
Treatment failure 63.85 19.11 5 38730 170481 79535172
Sepsis 63.00 19.11 26 38709 269402 79436251
Pulmonary oedema 62.84 19.11 135 38600 88119 79617534
Infection 62.13 19.11 20 38715 241692 79463961
Chemical submission 62.10 19.11 17 38718 320 79705333
Swelling 61.14 19.11 15 38720 216696 79488957
Malaise 60.73 19.11 90 38645 489779 79215874
Sopor 59.90 19.11 77 38658 32933 79672720
Seizure 59.22 19.11 214 38521 188620 79517033
Hypersensitivity 58.62 19.11 27 38708 262212 79443441
Opiates positive 58.51 19.11 21 38714 983 79704670
Back pain 58.31 19.11 38 38697 304142 79401511
Synovitis 57.65 19.11 4 38731 150730 79554923
Dizziness 56.66 19.11 106 38629 526335 79179318
Pancytopenia 56.48 19.11 7 38728 165738 79539915
Sinusitis 56.20 19.11 13 38722 195488 79510165
Haemoglobin decreased 56.00 19.11 19 38716 222100 79483553
Homicide 55.10 19.11 21 38714 1165 79704488
Drug abuser 54.86 19.11 35 38700 5978 79699675
Drug screen positive 54.59 19.11 35 38700 6028 79699625
Urticaria 53.87 19.11 12 38723 185189 79520464
Stomatitis 53.06 19.11 5 38730 146752 79558901
Medication error 52.35 19.11 108 38627 68534 79637119
Musculoskeletal stiffness 51.59 19.11 11 38724 174997 79530656
Victim of sexual abuse 50.27 19.11 16 38719 516 79705137
Platelet count decreased 50.21 19.11 16 38719 194648 79511005
Broncholithiasis 48.30 19.11 13 38722 229 79705424
Withdrawal syndrome 47.72 19.11 62 38673 26792 79678861
Therapeutic product effect decreased 46.89 19.11 11 38724 163852 79541801
Blood ethanol 46.82 19.11 12 38723 173 79705480
Shock 46.29 19.11 79 38656 43469 79662184
Malignant neoplasm progression 45.71 19.11 6 38729 135984 79569669
Amnesia 45.50 19.11 97 38638 62960 79642693
Abdominal pain 44.99 19.11 75 38660 389494 79316159
Electrocardiogram QT prolonged 44.64 19.11 120 38615 90266 79615387
Thrombocytopenia 44.55 19.11 38 38697 265221 79440432
Cardiac failure congestive 43.96 19.11 8 38727 142394 79563259
Amphetamines positive 43.85 19.11 13 38722 329 79705324
Postmortem blood drug level 43.63 19.11 13 38722 335 79705318
Brain oedema 42.84 19.11 57 38678 25206 79680447
Congestive hepatopathy 42.81 19.11 27 38708 4520 79701133
Septic shock 42.29 19.11 5 38730 122796 79582857
Blood ethanol increased 42.29 19.11 15 38720 678 79704975
Systemic lupus erythematosus 41.56 19.11 5 38730 121144 79584509
Lymph node calcification 41.37 19.11 13 38722 402 79705251
Abdominal distension 40.89 19.11 5 38730 119645 79586008
Road traffic accident 39.72 19.11 74 38661 43590 79662063
Product administration error 39.57 19.11 62 38673 31784 79673869
Somnambulism 39.47 19.11 28 38707 5693 79699960
Unresponsive to stimuli 39.31 19.11 85 38650 55703 79649950
Pericarditis 39.18 19.11 3 38732 104233 79601420
Hand deformity 39.04 19.11 3 38732 103916 79601737
Injection site pain 38.59 19.11 8 38727 129830 79575823
Accidental overdose 38.43 19.11 69 38666 39512 79666141
Cerebrovascular accident 37.90 19.11 14 38721 155278 79550375
Interstitial lung disease 37.77 19.11 5 38730 112595 79593058
Victim of chemical submission 37.68 19.11 13 38722 541 79705112
Rhabdomyolysis 37.65 19.11 123 38612 103008 79602645
COVID-19 37.18 19.11 15 38720 157659 79547994
Electrocardiogram ST segment elevation 35.96 19.11 31 38704 8366 79697287
Loss of personal independence in daily activities 35.77 19.11 4 38731 102576 79603077
Toxicologic test abnormal 35.66 19.11 16 38719 1344 79704309
Respiratory acidosis 35.61 19.11 35 38700 11165 79694488
Hepatic fibrosis 35.57 19.11 29 38706 7251 79698402
Alcohol intolerance 35.41 19.11 12 38723 473 79705180
Muscular weakness 35.21 19.11 17 38718 160712 79544941
Acute hepatic failure 35.18 19.11 57 38678 30056 79675597
Behaviour disorder 34.81 19.11 27 38708 6286 79699367
Abnormal behaviour 34.73 19.11 63 38672 36358 79669295
Sinus tachycardia 34.13 19.11 63 38672 36845 79668808
Hypoaesthesia 33.54 19.11 23 38712 179329 79526324
Pulmonary embolism 33.47 19.11 21 38714 171633 79534020
Mobility decreased 33.40 19.11 9 38726 122166 79583487
Musculoskeletal pain 33.26 19.11 5 38730 102349 79603304
Discomfort 32.97 19.11 10 38725 125607 79580046
Influenza 32.80 19.11 11 38724 129595 79576058
Fall 32.77 19.11 124 38611 487505 79218148
Pulmonary congestion 32.62 19.11 52 38683 27048 79678605
Oedema 32.33 19.11 9 38726 119571 79586082
Blister 32.29 19.11 9 38726 119467 79586186
Choroiditis 32.28 19.11 15 38720 1366 79704287
Myocardial fibrosis 32.09 19.11 16 38719 1702 79703951
Haematochezia 31.64 19.11 3 38732 87642 79618011
Herpes zoster 31.54 19.11 4 38731 93079 79612574
Osteoarthritis 31.48 19.11 3 38732 87306 79618347
Bradypnoea 31.46 19.11 25 38710 6027 79699626
Dehydration 31.28 19.11 45 38690 248142 79457511
Wheezing 31.14 19.11 9 38726 116655 79588998
Substance dependence 31.10 19.11 11 38724 493 79705160
Lower respiratory tract infection 30.95 19.11 12 38723 129208 79576445
Arthritis 30.41 19.11 9 38726 114871 79590782
Physical assault 30.08 19.11 15 38720 1596 79704057
Euphoric mood 30.04 19.11 27 38708 7699 79697954
Oropharyngeal pain 30.00 19.11 8 38727 109345 79596308
Bronchitis 29.88 19.11 13 38722 130631 79575022
Liver injury 29.81 19.11 77 38658 56537 79649116
Accidental poisoning 29.68 19.11 15 38720 1642 79704011
Hypothermia 29.26 19.11 45 38690 22701 79682952
C-reactive protein increased 29.26 19.11 13 38722 129014 79576639
Abdominal pain upper 28.78 19.11 40 38695 223779 79481874
Dysarthria 28.70 19.11 85 38650 67537 79638116
Chest pain 28.45 19.11 59 38676 282245 79423408
Upper respiratory tract infection 28.40 19.11 5 38730 91163 79614490
Chills 28.08 19.11 22 38713 160212 79545441
Lichen nitidus 28.06 19.11 7 38728 90 79705563
Deep vein thrombosis 27.71 19.11 12 38723 120907 79584746
Leukopenia 27.60 19.11 11 38724 116502 79589151
Drug level increased 27.46 19.11 60 38675 39591 79666062
Protein C increased 27.12 19.11 7 38728 104 79705549
Delirium tremens 27.02 19.11 11 38724 727 79704926
Oedema peripheral 26.90 19.11 51 38684 252237 79453416
Neuropathy peripheral 26.58 19.11 18 38717 141287 79564366
Myocarditis 26.57 19.11 42 38693 21691 79683962
Neck pain 26.14 19.11 3 38732 75414 79630239
Impaired driving ability 25.26 19.11 21 38714 5394 79700259
Colitis 25.20 19.11 3 38732 73304 79632349
Dysphagia 25.14 19.11 14 38721 122122 79583531
Suicidal behaviour 25.00 19.11 17 38718 3230 79702423
Therapy non-responder 24.86 19.11 7 38728 92298 79613355
Erythema 24.82 19.11 44 38691 223246 79482407
Myocardial infarction 24.59 19.11 32 38703 184097 79521556
Restlessness 24.24 19.11 63 38672 46429 79659224
Sudden death 24.13 19.11 41 38694 22470 79683183
Hepatic enzyme increased 24.12 19.11 32 38703 182578 79523075
Exposure via ingestion 24.00 19.11 20 38715 5154 79700499
Inappropriate schedule of product administration 23.85 19.11 18 38717 133610 79572043
Neutrophil count decreased 23.73 19.11 8 38727 93951 79611702
Fluid retention 23.65 19.11 3 38732 69806 79635847
Serotonin syndrome 23.46 19.11 61 38674 44966 79660687
Thrombosis 23.36 19.11 6 38729 84094 79621559
Bezoar 22.93 19.11 15 38720 2673 79702980
Migraine 22.89 19.11 7 38728 87486 79618167
Injection site erythema 22.86 19.11 5 38730 78192 79627461
Induced abortion failed 22.84 19.11 7 38728 199 79705454
Epistaxis 22.64 19.11 13 38722 111502 79594151
Incoherent 22.54 19.11 23 38712 7669 79697984
Visceral oedema 22.01 19.11 6 38729 111 79705542
Coma scale abnormal 21.97 19.11 24 38711 8654 79696999
Inflammation 21.97 19.11 9 38726 93744 79611909
Asthma 21.89 19.11 20 38715 135075 79570578
Sensorimotor disorder 21.80 19.11 10 38725 884 79704769
Therapeutic product effect incomplete 21.75 19.11 22 38713 141623 79564030
Substance-induced mood disorder 21.62 19.11 6 38729 119 79705534
Stress 21.51 19.11 6 38729 79606 79626047
Drug diversion 21.47 19.11 11 38724 1239 79704414
Blood pressure increased 21.43 19.11 44 38691 211316 79494337
Gastrooesophageal reflux disease 21.38 19.11 12 38723 104234 79601419
Hypotension 21.36 19.11 316 38419 440001 79265652
Pupil fixed 21.31 19.11 16 38719 3550 79702103
Acidosis 21.19 19.11 36 38699 19726 79685927
Hypertension 21.04 19.11 86 38649 330906 79374747
Dyspnoea exertional 20.99 19.11 8 38727 87065 79618588
Areflexia 20.85 19.11 19 38716 5515 79700138
Behavioural addiction 20.75 19.11 5 38730 55 79705598
Aspiration 20.67 19.11 36 38699 20122 79685531
Analgesic drug level increased 20.65 19.11 15 38720 3163 79702490
Brain death 20.43 19.11 19 38716 5658 79699995
Liver disorder 20.43 19.11 5 38730 72412 79633241
Blood pressure systolic increased 20.16 19.11 4 38731 66982 79638671
Rectal haemorrhage 20.15 19.11 6 38729 76294 79629359
Rash pruritic 20.11 19.11 5 38730 71624 79634029
Gastrointestinal disorder 19.90 19.11 18 38717 122187 79583466
Duodenal ulcer perforation 19.83 19.11 4 38731 66207 79639446
Psychiatric disorder prophylaxis 19.78 19.11 5 38730 68 79705585
Pneumonitis 19.71 19.11 3 38732 60857 79644796
Blood cholesterol increased 19.67 19.11 8 38727 83712 79621941
Gastrointestinal haemorrhage 19.39 19.11 26 38709 147693 79557960
Product use in unapproved indication 19.27 19.11 60 38675 250299 79455354
Rheumatoid factor positive 19.26 19.11 3 38732 59836 79645817
Gun shot wound 19.25 19.11 10 38725 1160 79704493

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AJ08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D08AJ58 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC R02AA09 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Skin irritation indication 367466007
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Prevent Minor Bacterial Skin Infection indication
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Conduction disorder of the heart contraindication 44808001
Bleeding hemorrhoids contraindication 51551000
Decreased respiratory function contraindication 80954004
Disorder of mucous membrane contraindication 95351003
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 5.93 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 7.05 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 5.89 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 6.05 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 7.43 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.27 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.53 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 7.00 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.69 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.09 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.44 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 7.02 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.55 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.97 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 5.65 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 6.12 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.68 DRUG MATRIX
Substance-K receptor GPCR Ki 6.19 DRUG MATRIX
KiSS-1 receptor GPCR Ki 5.44 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.16 DRUG MATRIX

External reference:

IDSource
N0000005872 NUI
D01140 KEGG_DRUG
4018649 VANDF
C0005041 UMLSCUI
CHEBI:94725 CHEBI
CHEMBL1182210 ChEMBL_ID
CHEMBL221753 ChEMBL_ID
D001558 MESH_DESCRIPTOR_UI
DB11125 DRUGBANK_ID
2335 PUBCHEM_CID
1VU15B70BP UNII
1390 RXNORM
11805 MMSL
NOCODE MMSL
003142 NDDF
126147005 SNOMEDCT_US
34929006 SNOMEDCT_US
373482005 SNOMEDCT_US
1170 INN_ID
10172-60-8 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Benzethonium chloride and Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 0363-0210 LIQUID 0.06 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride and Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 0363-0210 LIQUID 0.06 mg TOPICAL OTC monograph not final 15 sections
Walgreens Antiseptic Wound Wash HUMAN OTC DRUG LABEL 1 0363-1507 SOLUTION 1.30 mg TOPICAL OTC monograph not final 14 sections
Pyrocaine Burn HUMAN OTC DRUG LABEL 2 0498-0010 AEROSOL, SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
Pyrocaine Burn HUMAN OTC DRUG LABEL 2 0498-0010 AEROSOL, SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
Pyrocaine Burn HUMAN OTC DRUG LABEL 2 0498-0011 AEROSOL, SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
Pyrocaine Burn HUMAN OTC DRUG LABEL 2 0498-0011 AEROSOL, SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
North First Aid Antiseptic HUMAN OTC DRUG LABEL 2 0498-0015 SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
North Burn HUMAN OTC DRUG LABEL 3 0498-0020 SPRAY 0.20 g TOPICAL OTC monograph not final 12 sections
North Burn HUMAN OTC DRUG LABEL 3 0498-0020 SPRAY 0.20 g TOPICAL OTC monograph not final 12 sections
Burn Water Soluble HUMAN OTC DRUG LABEL 3 0498-0021 SPRAY 0.20 g TOPICAL OTC monograph not final 12 sections
Burn Water Soluble HUMAN OTC DRUG LABEL 3 0498-0021 SPRAY 0.20 g TOPICAL OTC monograph not final 12 sections
North First Aid Antiseptic Water Soluble HUMAN OTC DRUG LABEL 2 0498-0030 SPRAY 0.20 g TOPICAL OTC monograph not final 13 sections
North First Aid Antiseptic Water Soluble HUMAN OTC DRUG LABEL 2 0498-0030 SPRAY 0.20 g TOPICAL OTC monograph not final 13 sections
First Aid Antiseptic Water Soluble HUMAN OTC DRUG LABEL 2 0498-0031 SPRAY 0.20 g TOPICAL OTC monograph not final 13 sections
First Aid Antiseptic Water Soluble HUMAN OTC DRUG LABEL 2 0498-0031 SPRAY 0.20 g TOPICAL OTC monograph not final 13 sections
Simply Saline Plus Wound WashAntibacterial First Aid Antiseptic HUMAN OTC DRUG LABEL 1 10237-694 SPRAY 0.13 mL TOPICAL OTC monograph not final 10 sections
Simply SalineWound Care HUMAN OTC DRUG LABEL 1 10237-700 SPRAY 1 mg TOPICAL OTC monograph not final 11 sections
Moisturizing Hand Sanitizer HUMAN OTC DRUG LABEL 1 11344-478 LOTION 1.98 mg TOPICAL OTC monograph not final 10 sections
Moisturizing Hand Sanitizer HUMAN OTC DRUG LABEL 1 11344-478 LOTION 1.98 mg TOPICAL OTC monograph not final 10 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11673-629 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11673-629 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
Bedside-Care HUMAN OTC DRUG LABEL 1 11701-020 SHAMPOO 1 mL TOPICAL OTC monograph not final 10 sections
Bedside-Care Foam (Alcohol Free) HUMAN OTC DRUG LABEL 1 11701-052 SHAMPOO 100 mg TOPICAL OTC monograph not final 10 sections
Bedside-Care HUMAN OTC DRUG LABEL 1 11701-053 SHAMPOO 100 mg TOPICAL OTC monograph not final 10 sections
Bedside-Care Perineal Wash HUMAN OTC DRUG LABEL 1 11701-059 LIQUID 1 mL TOPICAL OTC monograph not final 10 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11822-0128 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11822-0128 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
Benzethonium Chloride and Dyclonine Hydrochloride HUMAN OTC DRUG LABEL 2 11822-0779 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
3 in 1 First Aid Wound Care HUMAN OTC DRUG LABEL 1 11822-5074 SOLUTION 1.30 mg TOPICAL OTC monograph not final 14 sections