benzethonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3018 121-54-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzethonium
  • benzethionium chloride
  • benzethonium chloride
  • benzetonium chloride
Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
  • Molecular weight: 412.64
  • Formula: C27H42NO2
  • CLOGP: 4.29
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 18.46
  • ALOGS: -7.78
  • ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5734.29 23.32 1985 14917 129904 50458318
Toxicity to various agents 3460.07 23.32 1579 15323 210920 50377302
Drug abuse 1620.48 23.32 643 16259 59203 50529019
Intentional overdose 1151.12 23.32 511 16391 61993 50526229
Cardio-respiratory arrest 1137.01 23.32 485 16417 53407 50534815
Overdose 829.14 23.32 476 16426 99251 50488971
Suicide attempt 672.49 23.32 333 16569 51399 50536823
Alcohol interaction 475.27 23.32 116 16786 2028 50586194
Suspected suicide 416.58 23.32 127 16775 5230 50582992
Respiratory arrest 322.04 23.32 170 16732 29839 50558383
Intentional product misuse 321.60 23.32 198 16704 46536 50541686
Cardiac arrest 288.25 23.32 232 16670 83419 50504803
Alcohol poisoning 259.00 23.32 69 16833 1731 50586491
Death 231.14 23.32 399 16503 324980 50263242
Alcohol use 219.83 23.32 62 16840 1933 50586289
Coma 206.97 23.32 163 16739 56716 50531506
Alcohol abuse 182.22 23.32 53 16849 1848 50586374
Somnolence 176.35 23.32 237 16665 154748 50433474
Drug ineffective 170.47 23.32 34 16868 819299 49768923
Exposure to toxic agent 140.60 23.32 51 16851 3607 50584615
Pain 110.14 23.32 29 16873 578874 50009348
Poisoning deliberate 105.65 23.32 52 16850 7860 50580362
Loss of consciousness 101.25 23.32 148 16754 104205 50484017
Diarrhoea 96.85 23.32 38 16864 588438 49999784
Mydriasis 93.91 23.32 53 16849 10574 50577648
Agitation 92.19 23.32 101 16801 53283 50534939
Fatigue 90.94 23.32 63 16839 707538 49880684
Arthralgia 89.20 23.32 19 16883 438683 50149539
Blood alcohol increased 86.61 23.32 23 16879 569 50587653
Poisoning 83.67 23.32 52 16850 12377 50575845
Alcoholism 83.06 23.32 28 16874 1592 50586630
Postmortem blood drug level abnormal 82.52 23.32 20 16882 338 50587884
Intentional self-injury 77.07 23.32 63 16839 23049 50565173
Substance abuse 76.42 23.32 34 16868 4090 50584132
Rash 72.27 23.32 28 16874 437443 50150779
Joint swelling 69.19 23.32 3 16899 245283 50342939
Seizure 67.32 23.32 132 16770 117742 50470480
Myocarditis 63.18 23.32 37 16865 7910 50580312
Condition aggravated 62.09 23.32 12 16890 297046 50291176
Drug dependence 62.00 23.32 52 16850 19707 50568515
Abdominal discomfort 61.68 23.32 4 16898 231637 50356585
Aggression 61.01 23.32 53 16849 21063 50567159
Drug use disorder 59.09 23.32 26 16876 3046 50585176
Alopecia 57.80 23.32 7 16895 245040 50343182
Suicidal ideation 57.23 23.32 81 16821 55304 50532918
Drug interaction 57.06 23.32 171 16731 199450 50388772
Drug withdrawal syndrome 56.94 23.32 55 16847 25026 50563196
Victim of sexual abuse 56.52 23.32 16 16886 505 50587717
Dyspnoea 56.48 23.32 60 16842 547548 50040674
Metabolic acidosis 56.09 23.32 67 16835 38758 50549464
Depressed level of consciousness 53.71 23.32 76 16826 51877 50536345
Liver injury 53.70 23.32 53 16849 24753 50563469
Pyrexia 51.15 23.32 32 16870 380171 50208051
Pneumonia 50.70 23.32 32 16870 378369 50209853
Swelling 49.22 23.32 5 16897 200867 50387355
Pruritus 48.69 23.32 17 16885 283551 50304671
Off label use 47.74 23.32 53 16849 474373 50113849
Drug intolerance 47.60 23.32 8 16894 219096 50369126
Asthenia 45.51 23.32 25 16877 319017 50269205
Anaemia 45.33 23.32 14 16888 252442 50335780
Drug hypersensitivity 44.92 23.32 14 16888 250996 50337226
Rheumatoid arthritis 44.88 23.32 7 16895 202543 50385679
Pain in extremity 44.10 23.32 18 16884 272847 50315375
Tachycardia 43.35 23.32 100 16802 99663 50488559
Somnambulism 41.99 23.32 24 16878 4900 50583322
Electrocardiogram QT prolonged 41.01 23.32 67 16835 51819 50536403
Chemical submission 40.67 23.32 10 16892 180 50588042
Sopor 40.32 23.32 41 16861 19838 50568384
Electrocardiogram QRS complex prolonged 40.17 23.32 24 16878 5320 50582902
Sinusitis 39.88 23.32 5 16897 170553 50417669
Asphyxia 39.83 23.32 24 16878 5403 50582819
Headache 38.60 23.32 69 16833 506466 50081756
Nasopharyngitis 37.81 23.32 9 16893 192918 50395304
Peripheral swelling 37.72 23.32 11 16891 205925 50382297
Product dose omission issue 37.18 23.32 8 16894 183830 50404392
Weight increased 36.58 23.32 11 16891 201880 50386342
Neutropenia 35.43 23.32 4 16898 147961 50440261
Protein C increased 34.48 23.32 8 16894 111 50588111
Urinary tract infection 34.24 23.32 16 16886 224004 50364218
Homicide 34.01 23.32 10 16892 362 50587860
Amnesia 33.97 23.32 55 16847 42205 50546017
Ventricular tachycardia 32.76 23.32 33 16869 15788 50572434
Treatment failure 32.26 23.32 4 16898 137633 50450589
Constipation 32.08 23.32 11 16891 185697 50402525
Broncholithiasis 32.03 23.32 8 16894 154 50588068
Lichen nitidus 32.01 23.32 7 16895 73 50588149
Cough 31.45 23.32 21 16881 241243 50346979
Accidental death 31.10 23.32 14 16888 1730 50586492
Nausea 30.47 23.32 127 16775 705271 49882951
Back pain 30.26 23.32 18 16884 220012 50368210
Substance dependence 30.20 23.32 8 16894 196 50588026
Abnormal behaviour 30.16 23.32 35 16867 19623 50568599
Induced abortion failed 29.07 23.32 8 16894 227 50587995
Lymph node calcification 28.97 23.32 8 16894 230 50587992
Shock 28.77 23.32 35 16867 20615 50567607
Hypotension 28.30 23.32 154 16748 235315 50352907
Sexual abuse 27.77 23.32 7 16895 140 50588082
Road traffic accident 27.21 23.32 37 16865 24315 50563907
Musculoskeletal stiffness 27.21 23.32 5 16897 128476 50459746
Congenital umbilical hernia 26.81 23.32 8 16894 305 50587917
Disinhibition 26.37 23.32 10 16892 800 50587422
Sinus tachycardia 26.25 23.32 34 16868 21320 50566902
Aspiration 26.24 23.32 23 16879 9241 50578981
Areflexia 24.92 23.32 14 16888 2766 50585456
Euphoric mood 24.87 23.32 16 16886 4039 50584183
Respiratory depression 24.77 23.32 25 16877 11985 50576237
Electrocardiogram ST segment elevation 24.56 23.32 15 16887 3458 50584764
Postmortem blood drug level 24.35 23.32 6 16896 109 50588113
Injection site pain 24.21 23.32 4 16898 111020 50477202
Blood ethanol increased 24.14 23.32 6 16896 113 50588109
Alcoholic 24.05 23.32 5 16897 40 50588182
Stomatitis 23.61 23.32 3 16899 101341 50486881
Malaise 23.49 23.32 48 16854 335484 50252738

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 4132.32 22.62 1664 18672 78219 29475972
Completed suicide 3668.34 22.62 1584 18752 88662 29465529
Toxicity to various agents 3235.47 22.62 1786 18550 171875 29382316
Intentional overdose 796.10 22.62 429 19907 38099 29516092
Cardio-respiratory arrest 785.17 22.62 467 19869 50134 29504057
Overdose 591.99 22.62 467 19869 79352 29474839
Alcohol abuse 533.34 22.62 173 20163 4160 29550031
Alcohol interaction 502.24 22.62 148 20188 2555 29551636
Suicide attempt 479.74 22.62 296 20040 33814 29520377
Intentional product misuse 475.37 22.62 296 20040 34365 29519826
Suspected suicide 369.91 22.62 129 20207 3891 29550300
Substance abuse 281.16 22.62 122 20214 6665 29547526
Alcohol poisoning 276.02 22.62 97 20239 2992 29551199
Drug dependence 269.32 22.62 172 20164 20809 29533382
Aggression 186.65 22.62 171 20165 35370 29518821
Respiratory arrest 186.08 22.62 149 20187 25684 29528507
Coma 175.18 22.62 173 20163 39277 29514914
Alcohol use 172.48 22.62 69 20267 3063 29551128
Respiratory depression 154.22 22.62 103 20233 13420 29540771
Exposure to toxic agent 135.82 22.62 55 20281 2520 29551671
Poisoning deliberate 129.72 22.62 68 20268 5663 29548528
Asphyxia 128.73 22.62 66 20270 5249 29548942
Intentional product use issue 124.94 22.62 150 20186 42348 29511843
Diarrhoea 116.44 22.62 42 20294 332656 29221535
Incorrect route of product administration 110.63 22.62 77 20259 10724 29543467
Blood alcohol increased 105.66 22.62 33 20303 697 29553494
Cardiac arrest 105.23 22.62 201 20135 85390 29468801
Pneumonia 102.89 22.62 46 20290 320126 29234065
Drug ineffective 95.40 22.62 67 20269 363103 29191088
Poisoning 92.54 22.62 67 20269 9926 29544265
Pyrexia 86.73 22.62 45 20291 287577 29266614
Fatigue 85.07 22.62 57 20279 316764 29237427
Anaemia 83.85 22.62 18 20318 200933 29353258
Drug withdrawal syndrome 83.72 22.62 81 20255 17903 29536288
Suicidal ideation 79.07 22.62 108 20228 34608 29519583
Rash 75.22 22.62 19 20317 189800 29364391
Neutropenia 74.27 22.62 4 20332 131707 29422484
Intentional self-injury 69.34 22.62 62 20274 12399 29541792
Alcohol withdrawal syndrome 67.87 22.62 28 20308 1345 29552846
Drug interaction 61.96 22.62 284 20052 197101 29357090
Death 57.80 22.62 417 19919 341667 29212524
Dyspnoea 57.53 22.62 85 20251 326647 29227544
Off label use 54.17 22.62 77 20259 300723 29253468
Drug use disorder 53.90 22.62 32 20304 3390 29550801
Miosis 52.98 22.62 44 20292 7965 29546226
Medication error 52.89 22.62 69 20267 21142 29533049
Agitation 52.81 22.62 112 20224 51192 29502999
Road traffic accident 52.49 22.62 59 20277 15502 29538689
Drug screen positive 50.80 22.62 32 20304 3769 29550422
Sopor 50.41 22.62 49 20287 10885 29543306
Accidental death 50.41 22.62 26 20310 2092 29552099
Alcoholism 50.23 22.62 28 20308 2633 29551558
Sepsis 49.75 22.62 18 20318 142664 29411527
Alcohol intolerance 49.49 22.62 16 20320 379 29553812
Arthralgia 48.02 22.62 18 20318 139599 29414592
Pain 47.02 22.62 30 20306 171402 29382789
Asthenia 46.21 22.62 48 20288 215202 29338989
Constipation 45.99 22.62 11 20325 114149 29440042
Mydriasis 45.69 22.62 36 20300 6049 29548142
Depressed level of consciousness 45.60 22.62 87 20249 36855 29517336
Hepatic fibrosis 45.02 22.62 28 20308 3224 29550967
Ex-drug abuser 44.87 22.62 12 20324 142 29554049
Disease progression 44.60 22.62 3 20333 81913 29472278
Haemoglobin decreased 44.54 22.62 10 20326 108365 29445826
Platelet count decreased 44.36 22.62 9 20327 104663 29449528
Amnesia 43.52 22.62 65 20271 22578 29531613
White blood cell count decreased 42.74 22.62 4 20332 83358 29470833
Fractional exhaled nitric oxide increased 42.15 22.62 14 20322 362 29553829
Pain in extremity 41.90 22.62 12 20324 110421 29443770
Infection 41.23 22.62 3 20333 76748 29477443
Nausea 40.27 22.62 87 20249 289168 29265023
Pancytopenia 40.07 22.62 5 20331 83163 29471028
General physical health deterioration 39.34 22.62 11 20325 102846 29451345
Decreased appetite 39.07 22.62 26 20310 145316 29408875
Somnolence 38.63 22.62 147 20189 93808 29460383
Product dose omission issue 37.44 22.62 10 20326 96373 29457818
Impaired driving ability 37.24 22.62 22 20314 2309 29551882
Back pain 37.20 22.62 12 20324 102272 29451919
Malignant neoplasm progression 36.68 22.62 4 20332 73855 29480336
Tachycardia 36.36 22.62 121 20215 72289 29481902
Drug abuser 36.20 22.62 26 20310 3801 29550390
Withdrawal syndrome 35.91 22.62 41 20295 10951 29543240
Metabolic acidosis 35.08 22.62 79 20257 37583 29516608
Pulmonary oedema 33.69 22.62 84 20252 42651 29511540
Cardiac failure congestive 33.68 22.62 6 20330 76575 29477616
Cough 33.61 22.62 23 20313 126704 29427487
Dysarthria 33.56 22.62 69 20267 30842 29523349
Loss of consciousness 33.05 22.62 119 20217 73937 29480254
Homicide 33.00 22.62 15 20321 913 29553278
Thrombocytopenia 32.51 22.62 27 20309 134796 29419395
Neuropathy peripheral 32.49 22.62 5 20331 71022 29483169
Foetal alcohol syndrome 31.63 22.62 9 20327 136 29554055
Oedema peripheral 29.93 22.62 17 20319 103540 29450651
Weight decreased 29.77 22.62 36 20300 150869 29403322
Urinary tract infection 29.07 22.62 7 20329 72347 29481844
Peripheral swelling 28.01 22.62 5 20331 63734 29490457
Myocardial fibrosis 28.01 22.62 14 20322 1054 29553137
Cerebrovascular accident 28.00 22.62 9 20327 76902 29477289
Physical assault 27.81 22.62 14 20322 1070 29553121
Brain oedema 27.77 22.62 38 20298 12182 29542009
Dehydration 27.63 22.62 23 20313 114725 29439466
Cardiac failure 27.61 22.62 10 20326 79277 29474914
Pruritus 27.43 22.62 24 20312 116825 29437366
Opiates positive 27.01 22.62 11 20325 511 29553680
Abdominal pain 27.00 22.62 32 20304 135325 29418866
Myocardial infarction 26.69 22.62 22 20314 110274 29443917
Deep vein thrombosis 26.34 22.62 4 20332 57395 29496796
Choroiditis 26.05 22.62 13 20323 975 29553216
Sensorimotor disorder 26.00 22.62 10 20326 399 29553792
Septic shock 25.23 22.62 6 20330 62554 29491637
Pleural effusion 25.15 22.62 9 20327 71899 29482292
Gun shot wound 24.90 22.62 13 20323 1072 29553119
Blood creatinine increased 24.54 22.62 14 20322 85088 29469103
Dextrocardia 24.11 22.62 7 20329 114 29554077
Unresponsive to stimuli 23.72 22.62 53 20283 25073 29529118
Shock 23.49 22.62 48 20288 21356 29532835
Rhabdomyolysis 23.22 22.62 93 20243 60715 29493476
Muscular weakness 23.05 22.62 7 20329 62045 29492146
Plantar fasciitis 22.88 22.62 13 20323 1268 29552923

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8839.30 21.76 3525 29515 220889 64244803
Toxicity to various agents 6445.29 21.76 3273 29767 360240 64105452
Drug abuse 5600.30 21.76 2202 30838 130172 64335520
Cardio-respiratory arrest 1884.61 21.76 944 32096 97449 64368243
Intentional overdose 1546.87 21.76 803 32237 89141 64376551
Overdose 1149.18 21.76 815 32225 158751 64306941
Alcohol interaction 809.12 21.76 224 32816 4177 64461515
Intentional product misuse 756.46 21.76 467 32573 71828 64393864
Suicide attempt 715.85 21.76 448 32592 70559 64395133
Suspected suicide 711.27 21.76 237 32803 8417 64457275
Alcohol abuse 538.55 21.76 167 32873 4685 64461007
Respiratory arrest 480.71 21.76 313 32727 52672 64413020
Alcohol poisoning 436.90 21.76 138 32902 4117 64461575
Cardiac arrest 356.14 21.76 416 32624 153648 64312044
Death 335.59 21.76 752 32288 481953 63983739
Coma 335.04 21.76 310 32730 87305 64378387
Alcohol use 326.83 21.76 113 32927 4489 64461203
Substance abuse 301.64 21.76 129 32911 9163 64456529
Drug dependence 300.01 21.76 196 32844 33116 64432576
Exposure to toxic agent 266.33 21.76 105 32935 6054 64459638
Drug ineffective 221.09 21.76 78 32962 840169 63625523
Poisoning deliberate 218.54 21.76 116 32924 13342 64452350
Diarrhoea 197.08 21.76 63 32977 722641 63743051
Aggression 193.05 21.76 172 32868 46060 64419632
Blood alcohol increased 166.92 21.76 49 32991 1133 64464559
Fatigue 161.50 21.76 92 32948 748638 63717054
Pain 158.44 21.76 44 32996 553467 63912225
Poisoning 150.30 21.76 109 32931 21770 64443922
Arthralgia 138.53 21.76 29 33011 442231 64023461
Respiratory depression 132.65 21.76 104 32936 23339 64442353
Asphyxia 131.87 21.76 74 32966 9492 64456200
Incorrect route of product administration 131.06 21.76 103 32937 23195 64442497
Somnolence 129.32 21.76 307 32733 203338 64262354
Pneumonia 128.96 21.76 63 32977 559513 63906179
Pyrexia 125.57 21.76 65 32975 558579 63907113
Intentional product use issue 124.10 21.76 195 32845 95169 64370523
Off label use 123.58 21.76 87 32953 632719 63832973
Dyspnoea 120.32 21.76 115 32925 718559 63747133
Agitation 119.59 21.76 184 32856 88183 64377509
Rash 119.44 21.76 43 32997 458506 64007186
Intentional self-injury 115.18 21.76 105 32935 28939 64436753
Anaemia 110.28 21.76 29 33011 378651 64087041
Mydriasis 106.79 21.76 77 32963 15235 64450457
Drug use disorder 100.58 21.76 53 32987 6001 64459691
Nausea 100.54 21.76 155 32885 785645 63680047
Joint swelling 93.23 21.76 4 33036 215378 64250314
Neutropenia 93.10 21.76 8 33032 239616 64226076
Metabolic acidosis 88.02 21.76 142 32898 70816 64394876
Postmortem blood drug level abnormal 87.77 21.76 26 33014 621 64465071
Loss of consciousness 86.97 21.76 217 32823 148148 64317544
Depressed level of consciousness 85.14 21.76 151 32889 81285 64384407
Pain in extremity 84.86 21.76 25 33015 303060 64162632
Alcoholism 83.82 21.76 39 33001 3378 64462314
Drug interaction 83.73 21.76 387 32653 361696 64103996
Accidental death 80.61 21.76 39 33001 3686 64462006
Suicidal ideation 79.59 21.76 131 32909 66411 64399281
Febrile neutropenia 79.54 21.76 4 33036 187653 64278039
Cough 77.45 21.76 29 33011 302119 64163573
Asthenia 76.83 21.76 64 32976 427980 64037712
Urinary tract infection 72.78 21.76 15 33025 231581 64234111
Condition aggravated 71.48 21.76 52 32988 372374 64093318
Miosis 71.06 21.76 57 32983 13209 64452483
Pruritus 70.56 21.76 36 33004 312364 64153328
Constipation 69.74 21.76 16 33024 229321 64236371
Drug intolerance 68.51 21.76 8 33032 187984 64277708
Alcohol withdrawal syndrome 68.46 21.76 28 33012 1775 64463917
Headache 67.96 21.76 104 32936 529363 63936329
Back pain 65.81 21.76 23 33017 250148 64215544
Nasopharyngitis 65.23 21.76 11 33029 196062 64269630
Drug withdrawal syndrome 64.70 21.76 80 32960 31211 64434481
Alopecia 63.07 21.76 6 33034 165684 64300008
Peripheral swelling 62.78 21.76 15 33025 209138 64256554
Pulmonary oedema 62.67 21.76 130 32910 78544 64387148
Rheumatoid arthritis 62.41 21.76 6 33034 164288 64301404
Sopor 61.60 21.76 76 32964 29585 64436107
Abdominal discomfort 61.16 21.76 10 33030 182312 64283380
Sepsis 60.89 21.76 21 33019 230320 64235372
Tachycardia 60.28 21.76 191 32849 149388 64316304
Drug hypersensitivity 58.98 21.76 24 33016 237791 64227901
Weight increased 57.17 21.76 19 33021 213329 64252363
Haemoglobin decreased 54.72 21.76 16 33024 195047 64270645
Homicide 54.63 21.76 21 33019 1130 64464562
Product dose omission issue 54.58 21.76 16 33024 194731 64270961
White blood cell count decreased 54.43 21.76 8 33032 157829 64307863
Decreased appetite 54.29 21.76 39 33001 281250 64184442
Disease progression 54.27 21.76 5 33035 141675 64324017
Drug abuser 54.27 21.76 35 33005 5773 64459919
Sinusitis 53.69 21.76 6 33034 145922 64319770
General physical health deterioration 53.40 21.76 19 33021 204406 64261286
Drug screen positive 52.24 21.76 34 33006 5695 64459997
Swelling 51.10 21.76 10 33030 160208 64305484
Weight decreased 50.86 21.76 43 32997 285696 64179996
Shock 50.81 21.76 79 32961 38161 64427531
Malaise 50.62 21.76 78 32962 396169 64069523
Pancytopenia 50.03 21.76 7 33033 143302 64322390
Infection 48.60 21.76 17 33023 184863 64280829
Opiates positive 48.47 21.76 18 33022 880 64464812
Electrocardiogram QRS complex prolonged 47.99 21.76 39 33001 9205 64456487
Treatment failure 47.91 21.76 3 33037 116813 64348879
Medication error 47.57 21.76 89 32951 49877 64415815
Road traffic accident 45.80 21.76 67 32973 30678 64435014
Hypersensitivity 43.78 21.76 23 33017 196429 64269263
Platelet count decreased 43.09 21.76 16 33024 167695 64297997
Blood ethanol increased 42.27 21.76 15 33025 643 64465049
Cardiac failure congestive 41.95 21.76 8 33032 130572 64335120
Thrombocytopenia 41.91 21.76 32 33008 223769 64241923
Urticaria 41.46 21.76 12 33028 147305 64318387
Hepatic fibrosis 41.19 21.76 29 33011 5523 64460169
Dizziness 40.78 21.76 101 32939 430062 64035630
Amnesia 39.89 21.76 81 32959 48188 64417504
Stomatitis 39.09 21.76 5 33035 109600 64356092
Rhabdomyolysis 38.65 21.76 119 32921 91607 64374085
Malignant neoplasm progression 38.27 21.76 6 33034 112865 64352827
Product administration error 37.97 21.76 58 32982 27585 64438107
Injection site pain 37.59 21.76 6 33034 111402 64354290
Abdominal pain 37.51 21.76 64 32976 312311 64153381
Cerebrovascular accident 37.29 21.76 12 33028 137571 64328121
Liver injury 37.22 21.76 60 32980 29872 64435820
Septic shock 37.15 21.76 5 33035 105432 64360260
Musculoskeletal stiffness 36.63 21.76 9 33031 123197 64342495
Unresponsive to stimuli 36.35 21.76 80 32960 50313 64415379
Electrocardiogram QT prolonged 35.28 21.76 105 32935 79343 64386349
Abdominal distension 35.17 21.76 4 33036 95990 64369702
Fall 34.89 21.76 104 32936 416722 64048970
Blood ethanol 34.89 21.76 9 33031 126 64465566
Accidental overdose 34.76 21.76 62 32978 33495 64432197
Chemical submission 34.62 21.76 10 33030 218 64465474
Brain oedema 34.18 21.76 49 32991 22026 64443666
Amphetamines positive 34.07 21.76 10 33030 231 64465461
Pulmonary congestion 34.07 21.76 51 32989 23829 64441863
Sinus tachycardia 34.02 21.76 60 32980 32128 64433564
Somnambulism 33.91 21.76 25 33015 5116 64460576
Interstitial lung disease 33.58 21.76 5 33035 97727 64367965
Toxicologic test abnormal 33.24 21.76 15 33025 1210 64464482
Therapeutic product effect decreased 33.19 21.76 9 33031 115342 64350350
Postmortem blood drug level 33.10 21.76 10 33030 256 64465436
Alcohol intolerance 33.08 21.76 11 33029 387 64465305
Victim of sexual abuse 32.83 21.76 11 33029 396 64465296
Deep vein thrombosis 32.63 21.76 7 33033 105175 64360517
Myocardial fibrosis 32.56 21.76 16 33024 1564 64464128
Euphoric mood 32.52 21.76 27 33013 6564 64459128
Abnormal behaviour 32.14 21.76 60 32980 33562 64432130
Withdrawal syndrome 31.86 21.76 49 32991 23443 64442249
Dehydration 31.31 21.76 39 33001 216724 64248968
Substance dependence 30.84 21.76 11 33029 479 64465213
Dysarthria 30.75 21.76 83 32957 59323 64406369
Mobility decreased 30.41 21.76 4 33036 85836 64379856
Oedema peripheral 29.18 21.76 39 33001 210278 64255414
Lichen nitidus 28.77 21.76 7 33033 76 64465616
Pulmonary embolism 28.59 21.76 20 33020 146336 64319356
Respiratory acidosis 28.52 21.76 30 33010 9825 64455867
Restlessness 28.51 21.76 63 32977 39722 64425970
Seizure 28.42 21.76 164 32876 166728 64298964
Acute hepatic failure 28.02 21.76 49 32991 26063 64439629
Influenza 27.63 21.76 10 33030 106521 64359171
Oropharyngeal pain 27.39 21.76 6 33034 88861 64376831
Herpes zoster 27.32 21.76 4 33036 79183 64386509
Impaired driving ability 27.08 21.76 21 33019 4633 64461059
Physical assault 27.01 21.76 14 33026 1532 64464160
Bronchitis 26.89 21.76 11 33029 108732 64356960
Muscular weakness 26.78 21.76 16 33024 127322 64338370
Protein C increased 26.75 21.76 7 33033 104 64465588
Pleural effusion 26.48 21.76 16 33024 126543 64339149
Musculoskeletal pain 26.07 21.76 5 33035 81289 64384403
Substance use disorder 26.01 21.76 9 33031 358 64465334
Chest pain 25.94 21.76 51 32989 235929 64229763
Leukopenia 25.43 21.76 10 33030 101232 64364460
Choroiditis 25.40 21.76 12 33028 1075 64464617
Arthritis 25.15 21.76 6 33034 83808 64381884
Bezoar 24.94 21.76 15 33025 2188 64463504
Broncholithiasis 24.52 21.76 7 33033 146 64465546
Loss of personal independence in daily activities 24.22 21.76 4 33036 72450 64393242
Chills 23.97 21.76 21 33019 137243 64328449
Discomfort 23.86 21.76 6 33034 80872 64384820
Abdominal pain upper 23.73 21.76 33 33007 174997 64290695
Injection site erythema 23.47 21.76 4 33036 70796 64394896
Oedema 23.22 21.76 9 33031 91926 64373766
Induced abortion failed 22.99 21.76 7 33033 184 64465508
Aspiration 22.59 21.76 35 33005 16850 64448842
Sensorimotor disorder 22.44 21.76 10 33030 783 64464909
Hypoaesthesia 22.29 21.76 23 33017 139085 64326607
Cardiac failure 22.23 21.76 21 33019 132352 64333340
Drug level increased 22.11 21.76 52 32988 34144 64431548
Accidental poisoning 22.11 21.76 12 33028 1441 64464251
Blister 22.04 21.76 7 33033 80960 64384732
Exposure via ingestion 21.97 21.76 19 33021 4883 64460809
Erythema 21.82 21.76 39 33001 187031 64278661
Dyspepsia 21.76 21.76 7 33033 80305 64385387

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AJ08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D08AJ58 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC R02AA09 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Skin irritation indication 367466007
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Prevent Minor Bacterial Skin Infection indication
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Conduction disorder of the heart contraindication 44808001
Bleeding hemorrhoids contraindication 51551000
Decreased respiratory function contraindication 80954004
Disorder of mucous membrane contraindication 95351003
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 5.93 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 7.05 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 5.89 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 6.05 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 7.43 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.27 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.53 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 7.00 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.69 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.09 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.44 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 7.02 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.55 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.97 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 5.65 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 6.12 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.68 DRUG MATRIX
Substance-K receptor GPCR Ki 6.19 DRUG MATRIX
KiSS-1 receptor GPCR Ki 5.44 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.16 DRUG MATRIX

External reference:

IDSource
N0000005872 NUI
D01140 KEGG_DRUG
4018649 VANDF
C0005041 UMLSCUI
CHEBI:94725 CHEBI
CHEMBL1182210 ChEMBL_ID
CHEMBL221753 ChEMBL_ID
D001558 MESH_DESCRIPTOR_UI
DB11125 DRUGBANK_ID
2335 PUBCHEM_CID
1VU15B70BP UNII
1390 RXNORM
11805 MMSL
NOCODE MMSL
003142 NDDF
126147005 SNOMEDCT_US
34929006 SNOMEDCT_US
373482005 SNOMEDCT_US
1170 INN_ID
10172-60-8 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Benzethonium chloride and Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 0363-0210 LIQUID 0.06 mg TOPICAL OTC monograph not final 15 sections
Walgreens Antiseptic Wound Wash HUMAN OTC DRUG LABEL 1 0363-1507 SOLUTION 1.30 mg TOPICAL OTC monograph not final 14 sections
Pyrocaine Burn HUMAN OTC DRUG LABEL 2 0498-0010 AEROSOL, SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
Pyrocaine Burn HUMAN OTC DRUG LABEL 2 0498-0011 AEROSOL, SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
North First Aid Antiseptic HUMAN OTC DRUG LABEL 2 0498-0015 SPRAY 0.20 g TOPICAL OTC monograph not final 11 sections
North Burn HUMAN OTC DRUG LABEL 3 0498-0020 SPRAY 0.20 g TOPICAL OTC monograph not final 12 sections
Burn Water Soluble HUMAN OTC DRUG LABEL 3 0498-0021 SPRAY 0.20 g TOPICAL OTC monograph not final 12 sections
North First Aid Antiseptic Water Soluble HUMAN OTC DRUG LABEL 2 0498-0030 SPRAY 0.20 g TOPICAL OTC monograph not final 13 sections
First Aid Antiseptic Water Soluble HUMAN OTC DRUG LABEL 2 0498-0031 SPRAY 0.20 g TOPICAL OTC monograph not final 13 sections
Simply Saline Plus Wound WashAntibacterial First Aid Antiseptic HUMAN OTC DRUG LABEL 1 10237-694 SPRAY 0.13 mL TOPICAL OTC monograph not final 10 sections
Simply SalineWound Care HUMAN OTC DRUG LABEL 1 10237-700 SPRAY 1 mg TOPICAL OTC monograph not final 11 sections
Moisturizing Hand Sanitizer HUMAN OTC DRUG LABEL 1 11344-478 LOTION 1.98 mg TOPICAL OTC monograph not final 10 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11673-629 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
Bedside-Care HUMAN OTC DRUG LABEL 1 11701-020 SHAMPOO 1 mL TOPICAL OTC monograph not final 10 sections
Bedside-Care Foam (Alcohol Free) HUMAN OTC DRUG LABEL 1 11701-052 SHAMPOO 100 mg TOPICAL OTC monograph not final 10 sections
Bedside-Care HUMAN OTC DRUG LABEL 1 11701-053 SHAMPOO 100 mg TOPICAL OTC monograph not final 10 sections
Bedside-Care Perineal Wash HUMAN OTC DRUG LABEL 1 11701-059 LIQUID 1 mL TOPICAL OTC monograph not final 10 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11822-0128 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
Benzethonium Chloride and Dyclonine Hydrochloride HUMAN OTC DRUG LABEL 2 11822-0779 LIQUID 0.20 mg TOPICAL OTC monograph not final 15 sections
3 in 1 First Aid Wound Care HUMAN OTC DRUG LABEL 1 11822-5074 SOLUTION 1.30 mg TOPICAL OTC monograph not final 14 sections
Mada MedicalFoam Sanitizer HUMAN OTC DRUG LABEL 1 11928-682 LIQUID 0.20 mL TOPICAL OTC monograph not final 8 sections
QS Plus Instant Hand Sanitizer HUMAN OTC DRUG LABEL 1 13302-575 LIQUID 2 mg TOPICAL OTC monograph not final 10 sections
QS Plus Hand Sanitizing Wipes HUMAN OTC DRUG LABEL 1 13302-785 CLOTH 2 mg TOPICAL OTC monograph not final 10 sections
Veti-Foam HUMAN OTC DRUG LABEL 1 13985-529 LIQUID 2 g TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
New Skin Bandage HUMAN OTC DRUG LABEL 1 16864-440 LIQUID 1.80 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
New Skin Bandage HUMAN OTC DRUG LABEL 1 16864-450 SPRAY 60 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
Dermoplast First Aid HUMAN OTC DRUG LABEL 2 16864-670 SPRAY 2 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
Wet Wipes HUMAN OTC DRUG LABEL 1 20276-432 SWAB 0.30 mL TOPICAL OTC monograph not final 11 sections
Wet Wipes HUMAN OTC DRUG LABEL 1 20276-433 SWAB 0.30 mL TOPICAL OTC monograph not final 11 sections
Saline Wound WashSignature Care HUMAN OTC DRUG LABEL 1 21130-762 LIQUID 0.10 g TOPICAL OTC monograph not final 7 sections