benzalkonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3017 139-07-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzalkonium chloride
  • benzalkonium
  • benzyldodecyldimethylammonium chloride
  • benzododecinium
A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA:
  • ALOGS: -7.85
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2969.22 9.90 1972 66450 129917 50406785
Toxicity to various agents 1853.78 9.90 1825 66597 210674 50326028
Drug abuse 881.12 9.90 694 67728 59152 50477550
Cardio-respiratory arrest 660.72 9.90 562 67860 53330 50483372
Intentional overdose 555.03 9.90 544 67878 61960 50474742
Overdose 420.19 9.90 592 67830 99135 50437567
Cardiac arrest 357.36 9.90 500 67922 83151 50453551
Local anaesthetic systemic toxicity 318.89 9.90 87 68335 525 50536177
Alcohol interaction 314.95 9.90 116 68306 2028 50534674
Suicide attempt 271.27 9.90 342 68080 51390 50485312
Suspected suicide 244.09 9.90 127 68295 5230 50531472
Toxic anterior segment syndrome 216.40 9.90 81 68341 1484 50535218
Methaemoglobinaemia 192.12 9.90 80 68342 1962 50534740
Respiratory arrest 177.67 9.90 211 68211 29798 50506904
Alcohol poisoning 174.35 9.90 72 68350 1728 50534974
Death 150.33 9.90 849 67573 324530 50212172
Intentional product misuse 149.09 9.90 244 68178 46490 50490212
Pemphigus 140.25 9.90 5 68417 120161 50416541
Alcohol use 138.23 9.90 63 68359 1932 50534770
Systemic lupus erythematosus 114.61 9.90 25 68397 140597 50396105
Glossodynia 113.61 9.90 12 68410 115557 50421145
Alcohol abuse 109.98 9.90 53 68369 1848 50534854
Synovitis 105.13 9.90 20 68402 123845 50412857
Alopecia 104.89 9.90 106 68316 244941 50291761
Sinusitis 104.42 9.90 482 67940 170076 50366626
Drug intolerance 104.20 9.90 86 68336 219018 50317684
Joint swelling 102.84 9.90 108 68314 245178 50291524
Therapy interrupted 102.03 9.90 131 68291 20021 50516681
Abdominal discomfort 99.36 9.90 100 68322 231541 50305161
Anaesthetic complication 93.38 9.90 46 68376 1684 50535018
Drug ineffective 88.16 9.90 699 67723 818634 49718068
Contraindicated product administered 87.65 9.90 46 68376 148912 50387790
Pulseless electrical activity 80.95 9.90 70 68352 6771 50529931
Wound 78.11 9.90 23 68399 105771 50430931
Anaphylactic shock 76.45 9.90 114 68308 20041 50516661
Infusion site swelling 76.09 9.90 69 68353 7107 50529595
Exposure to toxic agent 75.30 9.90 52 68370 3606 50533096
Coma 74 9.90 206 68216 56673 50480029
Seizure 73.46 9.90 335 68087 117539 50419163
Arthralgia 72.55 9.90 326 68096 438376 50098326
Hepatic enzyme increased 71.59 9.90 49 68373 137331 50399371
Somnolence 71.03 9.90 404 68018 154581 50382121
Pericarditis 70.50 9.90 11 68411 78678 50458024
Diarrhoea 69.31 9.90 489 67933 587987 49948715
General physical health deterioration 68.80 9.90 55 68367 142379 50394323
Incorrect route of product administration 68.55 9.90 104 68318 18562 50518140
Mydriasis 68.35 9.90 78 68344 10549 50526153
Generalised tonic-clonic seizure 67.72 9.90 125 68297 26185 50510517
Rheumatoid arthritis 67.46 9.90 106 68316 202444 50334258
Maternal exposure during delivery 67.28 9.90 31 68391 975 50535727
Infusion site pain 63.66 9.90 81 68341 12265 50524437
Anaphylactic reaction 62.81 9.90 188 68234 53867 50482835
Infusion site extravasation 62.32 9.90 61 68361 6915 50529787
Ventricular tachycardia 62.18 9.90 91 68331 15730 50520972
Body tinea 62.00 9.90 32 68390 1295 50535407
Loss of consciousness 58.75 9.90 288 68134 104065 50432637
Infusion site erythema 57.73 9.90 65 68357 8662 50528040
Extradural abscess 57.63 9.90 26 68396 778 50535924
Hypotension 57.29 9.90 527 67895 234942 50301760
Unresponsive to stimuli 56.84 9.90 127 68295 30482 50506220
Infusion site pruritus 56.39 9.90 45 68377 3892 50532810
Agitation 55.84 9.90 179 68243 53205 50483497
Arthropathy 55.10 9.90 80 68342 157826 50378876
Corneal oedema 55.05 9.90 30 68392 1357 50535345
Blood alcohol increased 55.04 9.90 23 68399 569 50536133
Postmortem blood drug level abnormal 54.91 9.90 20 68402 338 50536364
Swelling 54.57 9.90 119 68303 200753 50335949
Bradycardia 53.43 9.90 200 68222 64226 50472476
Helicobacter infection 51.95 9.90 4 68418 49698 50487004
Tachycardia 51.01 9.90 268 68154 99495 50437207
Poisoning deliberate 49.08 9.90 57 68365 7855 50528847
Rash 48.74 9.90 369 68053 437102 50099600
Therapeutic product effect decreased 48.38 9.90 68 68354 135982 50400720
Alcoholism 48.11 9.90 29 68393 1591 50535111
Extradural haematoma 46.08 9.90 28 68394 1559 50535143
Lagophthalmos 43.52 9.90 16 68406 278 50536424
Pulse absent 42.89 9.90 42 68380 4764 50531938
Substance abuse 42.44 9.90 39 68383 4085 50532617
Infection susceptibility increased 42.37 9.90 32 68390 2552 50534150
Infusion site haemorrhage 42.31 9.90 34 68388 2970 50533732
Inhibitory drug interaction 41.91 9.90 30 68392 2203 50534499
Ventricular fibrillation 41.88 9.90 61 68361 10498 50526204
Procedural hypotension 41.44 9.90 23 68399 1079 50535623
Respiratory depression 40.03 9.90 64 68358 11946 50524756
Asthenia 39.45 9.90 261 68161 318781 50217921
Drug interaction 38.50 9.90 426 67996 199195 50337507
Gastrointestinal toxicity 38.28 9.90 39 68383 4638 50532064
Incorrect drug administration rate 37.78 9.90 30 68392 2576 50534126
Impaired healing 37.54 9.90 24 68398 69762 50466940
Mobility decreased 37.19 9.90 32 68390 79916 50456786
Mental status changes 36.46 9.90 120 68302 36152 50500550
Folliculitis 36.24 9.90 5 68417 39220 50497482
Electrocardiogram ST segment elevation 36.05 9.90 33 68389 3440 50533262
Fear 36.03 9.90 68 68354 14481 50522221
Hypersensitivity 34.79 9.90 161 68261 215000 50321702
Anaesthetic complication neurological 34.76 9.90 12 68410 172 50536530
Victim of sexual abuse 34.67 9.90 16 68406 505 50536197
Infusion site bruising 34.52 9.90 27 68395 2268 50534434
Off label use 34.02 9.90 445 67977 473981 50062721
Bursitis infective 33.86 9.90 21 68401 1213 50535489
Administration site pain 33.80 9.90 17 68405 651 50536051
Hypopyon 33.78 9.90 17 68405 652 50536050
Stress cardiomyopathy 33.39 9.90 47 68375 7840 50528862
COVID-19 33.14 9.90 138 68284 46524 50490178
Infusion site urticaria 32.41 9.90 19 68403 990 50535712
Anterior chamber cell 32.34 9.90 15 68407 479 50536223
Type I hypersensitivity 31.50 9.90 26 68396 2359 50534343
Neutropenia 31.49 9.90 99 68323 147866 50388836
Muscle injury 31.45 9.90 6 68416 37105 50499597
Corneal epithelium defect 31.09 9.90 13 68409 322 50536380
Pulmonary toxicity 31.09 9.90 38 68384 5524 50531178
Fear of eating 30.91 9.90 13 68409 327 50536375
Sinus tachycardia 30.42 9.90 80 68342 21274 50515428
Retinal vasculitis 30.18 9.90 17 68405 821 50535881
Platelet aggregation inhibition 30.15 9.90 10 68412 126 50536576
Blister 30.05 9.90 43 68379 85375 50451327
Drug use disorder 29.59 9.90 28 68394 3044 50533658
Pneumocephalus 29.45 9.90 10 68412 136 50536566
Vitritis 29.37 9.90 17 68405 865 50535837
Administration site swelling 29.19 9.90 18 68404 1029 50535673
Aggression 28.96 9.90 78 68344 21038 50515664
Renal injury 28.85 9.90 46 68376 8565 50528137
Discomfort 28.75 9.90 65 68357 108315 50428387
Glucose tolerance impaired 28.66 9.90 35 68387 5083 50531619
Parophthalmia 28.53 9.90 12 68410 302 50536400
Acute kidney injury 28.44 9.90 186 68236 227872 50308830
Poisoning 28.22 9.90 56 68366 12373 50524329
Product use issue 27.76 9.90 106 68316 149369 50387333
Peripheral swelling 27.73 9.90 164 68258 205772 50330930
Electrocardiogram QRS complex prolonged 27.45 9.90 35 68387 5309 50531393
Myocarditis 27.38 9.90 43 68379 7904 50528798
Treatment failure 27.28 9.90 95 68327 137542 50399160
C-reactive protein increased 26.99 9.90 30 68392 66444 50470258
Chemical submission 26.87 9.90 10 68412 180 50536522
Aqueous fibrin 26.84 9.90 8 68414 69 50536633
Pulmonary oedema 26.76 9.90 134 68288 48804 50487898
Peripheral nerve injury 25.68 9.90 12 68410 390 50536312
Septic arthritis staphylococcal 25.48 9.90 12 68410 397 50536305
Depressed level of consciousness 25.47 9.90 138 68284 51815 50484887
Anhedonia 25.45 9.90 46 68376 9478 50527224
Dyspnoea 25.40 9.90 556 67866 547052 49989650
Drug dependence 25.13 9.90 71 68351 19688 50517014
Cyanosis 24.89 9.90 60 68362 15124 50521578
Kounis syndrome 24.89 9.90 17 68405 1158 50535544
Nystagmus 24.83 9.90 34 68388 5527 50531175
Bundle branch block left 24.72 9.90 36 68386 6194 50530508
Lower respiratory tract infection 24.52 9.90 58 68364 95143 50441559
Upper airway obstruction 24.44 9.90 13 68409 560 50536142
Pancytopenia 24.29 9.90 48 68374 83982 50452720
Shock 24.14 9.90 72 68350 20578 50516124
Spinal epidural haemorrhage 24.03 9.90 8 68414 102 50536600
Abdominal pain upper 23.54 9.90 123 68299 159186 50377516
Ear infection 23.53 9.90 83 68339 25887 50510815
Disease progression 23.44 9.90 60 68362 95806 50440896
Protein C increased 23.41 9.90 8 68414 111 50536591
Infusion site nodule 23.15 9.90 16 68406 1111 50535591
Fatigue 23.01 9.90 756 67666 706845 49829857
Product adhesion issue 22.93 9.90 29 68393 4363 50532339
Cardiac failure congestive 22.87 9.90 50 68372 84332 50452370
Neurotoxicity 22.84 9.90 57 68365 14683 50522019
Drug withdrawal syndrome 22.59 9.90 80 68342 25001 50511701
Hypoxia 22.55 9.90 132 68290 50991 50485711
Meningitis chemical 22.43 9.90 8 68414 127 50536575
Drug level increased 22.35 9.90 67 68355 19201 50517501
Removal of foreign body 22.24 9.90 5 68417 11 50536691
Arthritis 22.20 9.90 53 68369 86668 50450034
Thrombocytopenia 22.15 9.90 93 68329 127580 50409122
Staphylococcal infection 21.99 9.90 101 68321 35515 50501187
Punctate keratitis 21.98 9.90 12 68410 545 50536157
Leukopenia 21.82 9.90 36 68386 67492 50469210
Nerve root injury 21.74 9.90 6 68416 38 50536664
Apnoea 21.69 9.90 36 68386 6930 50529772
Unevaluable event 21.66 9.90 121 68301 45945 50490757
Atonic urinary bladder 21.49 9.90 7 68415 83 50536619
Sensory loss 21.48 9.90 38 68384 7700 50529002
Spinal anaesthesia 21.35 9.90 6 68416 41 50536661
Poor quality sleep 21.35 9.90 60 68362 16586 50520116
Respiratory acidosis 21.30 9.90 33 68389 5995 50530707
COVID-19 immunisation 21.24 9.90 13 68409 733 50535969
Impaired quality of life 21.19 9.90 33 68389 6023 50530679
Surgery 21.19 9.90 89 68333 30116 50506586
Type 2 diabetes mellitus 21.12 9.90 10 68412 34365 50502337
Cauda equina syndrome 21.11 9.90 13 68409 741 50535961
Upper respiratory tract infection 21.07 9.90 157 68265 65741 50470961
Nerve block 20.83 9.90 11 68411 467 50536235
Hyponatraemia 20.67 9.90 64 68358 96075 50440627
Ophthalmoplegia 20.67 9.90 16 68406 1324 50535378
Infusion site rash 20.65 9.90 16 68406 1326 50535376
Psoriatic arthropathy 20.47 9.90 20 68402 47012 50489690
Trigemino-cardiac reflex 20.42 9.90 6 68416 49 50536653
Homicide 20.40 9.90 10 68412 362 50536340
Condition aggravated 20.38 9.90 281 68141 296777 50239925
Ventricular hypokinesia 20.34 9.90 26 68396 3954 50532748
Somnambulism 20.34 9.90 29 68393 4895 50531807
Abortion spontaneous 20.31 9.90 16 68406 41756 50494946
Anaemia 20.23 9.90 231 68191 252225 50284477
Spinal epidural haematoma 20.22 9.90 14 68408 975 50535727
Miosis 20.18 9.90 33 68389 6277 50530425
Neuromuscular block prolonged 20.14 9.90 11 68411 500 50536202
Infusion site mass 20.08 9.90 15 68407 1177 50535525
Circulatory collapse 19.94 9.90 66 68356 19934 50516768
Postmortem blood drug level 19.81 9.90 7 68415 108 50536594
Delirium 19.78 9.90 103 68319 38089 50498613
Drug hypersensitivity 19.22 9.90 232 68190 250778 50285924
Substance dependence 19.22 9.90 8 68414 196 50536506
Glossoptosis 19.08 9.90 6 68416 63 50536639
Orthostatic hypotension 19.02 9.90 8 68414 29473 50507229
Emotional distress 18.98 9.90 83 68339 28580 50508122
Accidental death 18.94 9.90 17 68405 1727 50534975
Status epilepticus 18.87 9.90 50 68372 13356 50523346
Ventricular extrasystoles 18.81 9.90 43 68379 10473 50526229
Loss of personal independence in daily activities 18.58 9.90 42 68380 70008 50466694
Electrocardiogram QT prolonged 18.55 9.90 127 68295 51759 50484943
Decreased appetite 18.47 9.90 178 68244 200745 50335957
Tryptase increased 18.43 9.90 8 68414 218 50536484
Induced abortion failed 18.13 9.90 8 68414 227 50536475
Pain 17.95 9.90 622 67800 578281 49958421
Infusion related reaction 17.88 9.90 145 68277 169412 50367290
Ill-defined disorder 17.79 9.90 29 68393 54625 50482077
Therapy cessation 17.75 9.90 76 68346 25935 50510767
Infusion site reaction 17.34 9.90 18 68404 2188 50534514
Accidental overdose 17.33 9.90 62 68360 19471 50517231
Amnesia 17.28 9.90 107 68315 42153 50494549
Nasopharyngitis 17.28 9.90 172 68250 192755 50343947
Areflexia 17.19 9.90 20 68402 2760 50533942
Eye infarction 17.11 9.90 5 68417 40 50536662
Alcoholic 17.11 9.90 5 68417 40 50536662
Septic shock 17.10 9.90 32 68390 57143 50479559
Injury 17.05 9.90 119 68303 48806 50487896
Hip arthroplasty 17.01 9.90 10 68412 30419 50506283
Cardiogenic shock 16.94 9.90 53 68369 15546 50521156
Serotonin syndrome 16.70 9.90 72 68350 24641 50512061
Stridor 16.67 9.90 21 68401 3148 50533554
Axillary nerve injury 16.66 9.90 4 68418 13 50536689
Anorgasmia 16.65 9.90 10 68412 545 50536157
Procedural complication 16.48 9.90 26 68396 4797 50531905
Endophthalmitis 16.42 9.90 20 68402 2896 50533806
Blood ethanol 16.39 9.90 5 68417 47 50536655
Phrenic nerve paralysis 16.39 9.90 6 68416 103 50536599
Drug reaction with eosinophilia and systemic symptoms 16.37 9.90 9 68413 28415 50508287
Malignant neoplasm progression 16.37 9.90 43 68379 68081 50468621
Femur fracture 16.22 9.90 16 68406 37448 50499254
Hypocalcaemia 16.17 9.90 8 68414 26808 50509894
Abdominal pain 15.99 9.90 224 68198 236004 50300698
Congenital umbilical hernia 15.94 9.90 8 68414 305 50536397
Blood ethanol increased 15.87 9.90 6 68416 113 50536589
Anaphylactoid shock 15.82 9.90 8 68414 310 50536392
Tracheal deviation 15.77 9.90 5 68417 54 50536648
Interstitial lung disease 15.69 9.90 30 68392 53146 50483556
Stomatitis 15.67 9.90 77 68345 101267 50435435
Nail bed tenderness 15.56 9.90 8 68414 321 50536381
Brain death 15.53 9.90 19 68403 2764 50533938
Eyelid ptosis 15.42 9.90 29 68393 6158 50530544
Incision site rash 15.29 9.90 4 68418 20 50536682
Trigeminal palsy 15.29 9.90 4 68418 20 50536682
Opiates positive 15.25 9.90 8 68414 335 50536367
Haemoglobin decreased 15.21 9.90 105 68317 127111 50409591
Neoplasm malignant 15.19 9.90 68 68354 23647 50513055
Anal sphincter atony 14.97 9.90 7 68415 228 50536474
Musculoskeletal stiffness 14.90 9.90 107 68315 128374 50408328
Blood creatinine increased 14.79 9.90 53 68369 76107 50460595
Cholestasis 14.69 9.90 8 68414 25393 50511309
Intentional self-injury 14.60 9.90 66 68356 23046 50513656
Cough 14.53 9.90 234 68188 241030 50295672
Hepatotoxicity 14.49 9.90 74 68348 27152 50509550
Administration site erythema 14.41 9.90 9 68413 526 50536176
Intentional dose omission 14.28 9.90 25 68397 5025 50531677
Dissociative amnesia 14.28 9.90 4 68418 27 50536675
Administration site extravasation 14.26 9.90 10 68412 711 50535991
Pruritus 14.24 9.90 284 68138 283284 50253418
Body dysmorphic disorder 14.17 9.90 7 68415 258 50536444
Pupillary reflex impaired 14.16 9.90 15 68407 1866 50534836
Systemic toxicity 14.15 9.90 4 68418 28 50536674
Amphetamines positive 14.08 9.90 6 68416 156 50536546
Illness 13.98 9.90 68 68354 24472 50512230
Anaphylactoid reaction 13.98 9.90 20 68402 3386 50533316
Gastroenteritis 13.96 9.90 7 68415 23274 50513428
Paralysis 13.95 9.90 34 68388 8630 50528072
Blood cholesterol increased 13.93 9.90 34 68388 55181 50481521
Propionibacterium infection 13.80 9.90 4 68418 31 50536671
Vitamin D increased 13.75 9.90 9 68413 571 50536131
Arthritis bacterial 13.56 9.90 26 68396 5603 50531099
Brain injury 13.54 9.90 27 68395 5987 50530715
Road traffic accident 13.53 9.90 67 68355 24285 50512417
Airway peak pressure increased 13.46 9.90 7 68415 288 50536414
Red blood cell sedimentation rate increased 13.40 9.90 12 68410 29404 50507298
Vascular resistance systemic decreased 13.24 9.90 5 68417 94 50536608
Disinhibition 13.21 9.90 10 68412 800 50535902
Malaise 13.21 9.90 349 68073 335183 50201519
Harlequin syndrome 13.17 9.90 4 68418 37 50536665
Genital ulceration 13.17 9.90 8 68414 445 50536257
Implant site swelling 12.99 9.90 8 68414 456 50536246
Asphyxia 12.99 9.90 25 68397 5402 50531300
Conjunctival oedema 12.91 9.90 9 68413 634 50536068
Multiple sclerosis relapse 12.88 9.90 24 68398 42940 50493762
Orbital infection 12.80 9.90 4 68418 41 50536661
Anal skin tags 12.80 9.90 7 68415 319 50536383
Application site alopecia 12.68 9.90 3 68419 9 50536693
Prescribed underdose 12.65 9.90 3 68419 15946 50520756
Adverse event 12.64 9.90 25 68397 43738 50492964
Product contamination microbial 12.59 9.90 6 68416 204 50536498
Osteoarthritis 12.50 9.90 49 68373 68557 50468145
Suicidal ideation 12.45 9.90 122 68300 55263 50481439
Bone density decreased 12.37 9.90 38 68384 11037 50525665
Visual acuity reduced 12.35 9.90 57 68365 20082 50516620
Pain in extremity 12.32 9.90 278 68144 272587 50264115
Cardiac death 12.31 9.90 8 68414 501 50536201
Cholestasis of pregnancy 12.24 9.90 11 68411 1120 50535582
Metabolic acidosis 12.13 9.90 92 68330 38733 50497969
Psoriasis 12.12 9.90 50 68372 68950 50467752
Peritonitis 12.11 9.90 3 68419 15483 50521219
Intentional product use issue 12.10 9.90 158 68264 76760 50459942
Foetal heart rate abnormal 12.07 9.90 8 68414 518 50536184
Fear-related avoidance of activities 12.03 9.90 5 68417 122 50536580
Purpura 12.01 9.90 35 68387 9876 50526826
Spinal cord oedema 11.99 9.90 5 68417 123 50536579
Inadequate analgesia 11.97 9.90 16 68406 2542 50534160
Dermatitis contact 11.92 9.90 32 68390 8614 50528088
Osteonecrosis of jaw 11.81 9.90 16 68406 32510 50504192
Left ventricle outflow tract obstruction 11.73 9.90 6 68416 238 50536464
Bronchitis 11.72 9.90 202 68220 103957 50432745
Device expulsion 11.70 9.90 13 68409 28809 50507893
Knee arthroplasty 11.68 9.90 19 68403 35827 50500875
Birth mark 11.63 9.90 5 68417 133 50536569
Blood pressure decreased 11.53 9.90 121 68301 55788 50480914
Coccygectomy 11.47 9.90 3 68419 15 50536687
Arthritis fungal 11.47 9.90 3 68419 15 50536687
Kidney infection 11.45 9.90 53 68369 18693 50518009
Weight decreased 11.28 9.90 221 68201 221024 50315678
Autonomic neuropathy 11.25 9.90 10 68412 1003 50535699
Pneumocystis jirovecii pneumonia 11.16 9.90 3 68419 14660 50522042
Vascular stenosis 11.10 9.90 6 68416 267 50536435
Pupil fixed 11.02 9.90 12 68410 1540 50535162
Post procedural complication 10.98 9.90 45 68377 15059 50521643
Lung disorder 10.97 9.90 28 68394 44771 50491931
Drug resistance 10.96 9.90 6 68416 18983 50517719
Neoplasm progression 10.93 9.90 14 68408 29143 50507559
Repetitive strain injury 10.92 9.90 5 68417 155 50536547
Haemorrhagic vasculitis 10.91 9.90 4 68418 69 50536633
Liver injury 10.90 9.90 64 68358 24742 50511960
Cerebral congestion 10.87 9.90 3 68419 19 50536683
Intercepted medication error 10.87 9.90 7 68415 432 50536270
Retinal cyst 10.85 9.90 4 68418 70 50536632
Toxicologic test abnormal 10.85 9.90 8 68414 615 50536087
Ataxia 10.76 9.90 42 68380 13744 50522958
Pneumonia mycoplasmal 10.68 9.90 9 68413 840 50535862
Agranulocytosis 10.67 9.90 8 68414 21413 50515289
Paranasal cyst 10.61 9.90 6 68416 292 50536410
Gastrointestinal haemorrhage 10.60 9.90 57 68365 73264 50463438
Hemiplegic migraine 10.60 9.90 4 68418 75 50536627
Haematochezia 10.50 9.90 24 68398 39858 50496844
Neurogenic shock 10.50 9.90 6 68416 298 50536404
White blood cell count decreased 10.47 9.90 104 68318 116618 50420084
Blood pressure systolic increased 10.46 9.90 20 68402 35429 50501273
Infusion site discomfort 10.42 9.90 9 68413 869 50535833
Anxiety 10.39 9.90 314 68108 177292 50359410
Drug eruption 10.32 9.90 10 68412 23596 50513106
Transferrin decreased 10.30 9.90 5 68417 177 50536525
Fanconi syndrome 10.27 9.90 10 68412 1126 50535576
Cranial nerve palsies multiple 10.26 9.90 3 68419 24 50536678
Femoral nerve injury 10.26 9.90 3 68419 24 50536678
Withdrawal syndrome 10.21 9.90 49 68373 17541 50519161
Electrocardiogram ST segment depression 10.19 9.90 15 68407 2605 50534097
Blood lactic acid increased 10.17 9.90 23 68399 5562 50531140
Obesity 10.12 9.90 5 68417 16770 50519932
Product administration error 10.11 9.90 53 68369 19646 50517056
Spinal cord compression 10.02 9.90 18 68404 3691 50533011
Diplopia 10.01 9.90 52 68370 19208 50517494
Exposure during pregnancy 10.00 9.90 224 68198 120791 50415911

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2886.05 11.06 1727 46725 78156 29447919
Toxicity to various agents 2353.99 11.06 2069 46383 171592 29354483
Completed suicide 2332.28 11.06 1580 46872 88666 29437409
Cardio-respiratory arrest 523.40 11.06 522 47930 50079 29475996
Intentional overdose 522.39 11.06 462 47990 38066 29488009
Overdose 445.63 11.06 599 47853 79220 29446855
Alcohol abuse 396.45 11.06 176 48276 4157 29521918
Alcohol interaction 376.00 11.06 148 48304 2555 29523520
Intentional product misuse 306.53 11.06 329 48123 34332 29491743
Suicide attempt 277.68 11.06 310 48142 33800 29492275
Suspected suicide 258.53 11.06 128 48324 3892 29522183
Substance abuse 218.33 11.06 137 48315 6650 29519425
Methaemoglobinaemia 204.93 11.06 96 48356 2575 29523500
Cardiac arrest 198.59 11.06 435 48017 85156 29440919
Alcohol poisoning 194.61 11.06 97 48355 2992 29523083
Respiratory arrest 175.45 11.06 214 48238 25619 29500456
Drug dependence 167.77 11.06 189 48263 20792 29505283
Respiratory depression 151.60 11.06 146 48306 13377 29512698
Coma 142.46 11.06 242 48210 39208 29486867
Alcohol use 118.10 11.06 70 48382 3062 29523013
Anaesthetic complication 113.05 11.06 47 48405 939 29525136
Diarrhoea 112.51 11.06 236 48216 332462 29193613
Anaphylactic reaction 111.44 11.06 178 48274 27395 29498680
Aggression 97.90 11.06 194 48258 35347 29490728
Exposure to toxic agent 93.05 11.06 56 48396 2519 29523556
Toxic anterior segment syndrome 91.28 11.06 41 48411 995 29525080
Incorrect route of product administration 90.95 11.06 100 48352 10701 29515374
Asphyxia 84.65 11.06 70 48382 5245 29520830
Tachycardia 80.22 11.06 281 48171 72129 29453946
Poisoning deliberate 80.05 11.06 70 48382 5661 29520414
Injury 79.77 11.06 125 48327 18921 29507154
Hypotension 78.64 11.06 566 47886 193788 29332287
Death 78.57 11.06 880 47572 341204 29184871
Blood alcohol increased 77.69 11.06 33 48419 697 29525378
Fear 73.20 11.06 84 48368 9420 29516655
Intentional product use issue 71.53 11.06 191 48261 42307 29483768
Poisoning 71.42 11.06 85 48367 9908 29516167
Unresponsive to stimuli 71.41 11.06 139 48313 24987 29501088
Anaemia 69.88 11.06 140 48312 200811 29325264
Anaphylactic shock 68.01 11.06 96 48356 13240 29512835
Mydriasis 66.87 11.06 65 48387 6020 29520055
Miosis 62.04 11.06 71 48381 7938 29518137
Renal injury 60.46 11.06 79 48373 10123 29515952
Ventricular tachycardia 59.48 11.06 121 48331 22453 29503622
Local anaesthetic systemic toxicity 58.95 11.06 19 48433 176 29525899
General physical health deterioration 56.70 11.06 51 48401 102806 29423269
Dyspnoea 53.24 11.06 316 48136 326416 29199659
Anhedonia 52.70 11.06 62 48390 7138 29518937
Emotional distress 52.45 11.06 87 48365 13808 29512267
Decreased appetite 52.43 11.06 99 48353 145243 29380832
Weight decreased 49.99 11.06 108 48344 150797 29375278
Fatigue 49.72 11.06 310 48142 316511 29209564
Accidental overdose 49.59 11.06 97 48355 17496 29508579
Disease progression 47.10 11.06 39 48413 81877 29444198
Alcohol withdrawal syndrome 44.86 11.06 28 48424 1345 29524730
Drug withdrawal syndrome 44.56 11.06 94 48358 17890 29508185
Medication error 43.71 11.06 103 48349 21108 29504967
Interstitial lung disease 43.55 11.06 20 48432 57698 29468377
Pulmonary oedema 42.34 11.06 160 48292 42575 29483500
Electrocardiogram QRS complex prolonged 41.63 11.06 42 48410 4068 29522007
Rash 41.63 11.06 165 48287 189654 29336421
Pyrexia 40.78 11.06 290 48162 287332 29238743
Drug screen positive 40.64 11.06 40 48412 3761 29522314
Generalised tonic-clonic seizure 40.60 11.06 94 48358 19045 29507030
Drug use disorder 40.34 11.06 38 48414 3384 29522691
Suicidal ideation 39.50 11.06 136 48316 34580 29491495
Brain oedema 38.93 11.06 71 48381 12149 29513926
Electrocardiogram ST segment elevation 38.52 11.06 42 48410 4450 29521625
Neutropenia 38.25 11.06 101 48351 131610 29394465
Accidental death 38.19 11.06 30 48422 2088 29523987
Loss of consciousness 37.28 11.06 228 48224 73828 29452247
Asthenia 37.22 11.06 204 48248 215046 29311029
Cardiac failure congestive 36.49 11.06 43 48409 76538 29449537
Therapy interrupted 36.44 11.06 56 48396 8330 29517745
Depressed level of consciousness 36.33 11.06 138 48314 36804 29489271
Agitation 36.02 11.06 173 48279 51131 29474944
Alcohol intolerance 35.97 11.06 16 48436 379 29525696
Road traffic accident 35.87 11.06 79 48373 15482 29510593
Anaesthetic complication neurological 35.61 11.06 15 48437 310 29525765
Haemoglobin decreased 35.50 11.06 78 48374 108297 29417778
Ventricular fibrillation 34.95 11.06 79 48373 15754 29510321
Malaise 34.80 11.06 139 48313 159463 29366612
Ex-drug abuser 34.60 11.06 12 48440 142 29525933
White blood cell count decreased 34.43 11.06 52 48400 83310 29442765
Sinus tachycardia 34.17 11.06 76 48376 14993 29511082
Arthralgia 34.11 11.06 116 48336 139501 29386574
Pneumonia 34.07 11.06 348 48104 319824 29206251
Off label use 33.23 11.06 324 48128 300476 29225599
Myocardial infarction 33.22 11.06 83 48369 110213 29415862
Metabolic acidosis 32.46 11.06 135 48317 37527 29488548
Platelet count decreased 32.13 11.06 78 48374 104594 29421481
Oedema peripheral 31.92 11.06 77 48375 103480 29422595
Drug intolerance 31.76 11.06 20 48432 48359 29477716
Abdominal pain 30.71 11.06 116 48336 135241 29390834
Bradycardia 30.50 11.06 198 48254 65431 29460644
Acute kidney injury 30.43 11.06 283 48169 264984 29261091
Alcoholism 30.32 11.06 29 48423 2632 29523443
Oculocardiac reflex 30.26 11.06 9 48443 62 29526013
Drug abuser 29.76 11.06 34 48418 3793 29522282
Shock 28.99 11.06 89 48363 21315 29504760
Dehydration 28.24 11.06 95 48357 114653 29411422
Pain in extremity 28.17 11.06 90 48362 110343 29415732
Homicide 28.01 11.06 18 48434 910 29525165
Sinusitis 27.95 11.06 121 48331 34229 29491846
Cardiac failure 27.69 11.06 55 48397 79232 29446843
Intentional self-injury 27.31 11.06 62 48390 12399 29513676
Condition aggravated 27.30 11.06 135 48317 146160 29379915
Cough 27.21 11.06 111 48341 126616 29399459
Malignant neoplasm progression 26.87 11.06 50 48402 73809 29452266
Dysarthria 26.79 11.06 111 48341 30800 29495275
Infusion site pain 26.23 11.06 28 48424 2897 29523178
Thrombocytopenia 25.97 11.06 123 48329 134700 29391375
Impaired driving ability 25.80 11.06 25 48427 2306 29523769
Myocardial fibrosis 25.71 11.06 18 48434 1050 29525025
Hepatic fibrosis 25.47 11.06 29 48423 3223 29522852
Removal of foreign body 25.29 11.06 6 48446 14 29526061
Myalgia 24.45 11.06 53 48399 73966 29452109
Embolia cutis medicamentosa 24.37 11.06 10 48442 193 29525882
Unevaluable event 24.17 11.06 105 48347 29746 29496329
Foetal alcohol syndrome 23.95 11.06 9 48443 136 29525939
Drug reaction with eosinophilia and systemic symptoms 23.91 11.06 8 48444 27984 29498091
Neuropathy peripheral 23.34 11.06 51 48401 70976 29455099
Rheumatoid arthritis 22.94 11.06 12 48440 32140 29493935
Cytomegalovirus infection 22.90 11.06 5 48447 23210 29502865
Bezoar 22.56 11.06 15 48437 804 29525271
Corneal oedema 22.39 11.06 17 48435 1125 29524950
Angina pectoris 22.03 11.06 9 48443 27841 29498234
Haematochezia 22.00 11.06 17 48435 36966 29489109
Circulatory collapse 21.98 11.06 74 48378 18599 29507476
Diabetes mellitus 21.63 11.06 20 48432 39811 29486264
Behaviour disorder 21.42 11.06 28 48424 3588 29522487
Spinal cord infarction 21.35 11.06 10 48442 268 29525807
Leukopenia 21.31 11.06 36 48416 55167 29470908
Blood creatinine increased 21.24 11.06 70 48382 85032 29441043
Agranulocytosis 20.85 11.06 4 48448 20336 29505739
Opiates positive 20.55 11.06 12 48440 510 29525565
Loss of personal independence in daily activities 20.49 11.06 8 48444 25432 29500643
Pulmonary embolism 20.48 11.06 61 48391 76473 29449602
Intracranial hypotension 20.36 11.06 9 48443 210 29525865
Pupil fixed 20.31 11.06 19 48433 1677 29524398
Psoriasis 20.23 11.06 14 48438 32213 29493862
Coronary artery disease 19.79 11.06 26 48426 44164 29481911
Somnolence 19.72 11.06 238 48214 93717 29432358
Anxiety 19.59 11.06 220 48232 85145 29440930
Restlessness 19.56 11.06 80 48372 22065 29504010
Eosinophilia 19.51 11.06 6 48446 22155 29503920
Accident 19.47 11.06 27 48425 3661 29522414
Lagophthalmos 19.45 11.06 7 48445 93 29525982
Pancytopenia 19.02 11.06 71 48381 83097 29442978
Respiratory acidosis 18.94 11.06 29 48423 4299 29521776
Apnoea 18.86 11.06 35 48417 6067 29520008
Therapeutic product effect incomplete 18.79 11.06 22 48430 39283 29486792
Acute pulmonary oedema 18.64 11.06 37 48415 6742 29519333
Asthma 18.37 11.06 17 48435 33832 29492243
Sopor 18.23 11.06 49 48403 10885 29515190
Dextrocardia 18.15 11.06 7 48445 114 29525961
Reperfusion arrhythmia 17.94 11.06 6 48446 63 29526012
Dyspnoea exertional 17.90 11.06 20 48432 36470 29489605
Tryptase increased 17.89 11.06 8 48444 192 29525883
Pruritus 17.89 11.06 115 48337 116734 29409341
Amnesia 17.83 11.06 79 48373 22564 29503511
Weight increased 17.82 11.06 65 48387 76602 29449473
Melaena 17.71 11.06 15 48437 31161 29494914
Sensorimotor disorder 17.70 11.06 10 48442 399 29525676
Deep vein thrombosis 17.42 11.06 43 48409 57356 29468719
Gastrointestinal disorder 17.33 11.06 13 48439 28693 29497382
Tubulointerstitial nephritis 17 11.06 4 48448 17639 29508436
Catecholamine crisis 16.86 11.06 5 48447 34 29526041
Sepsis 16.84 11.06 151 48301 142531 29383544
Haematuria 16.84 11.06 29 48423 44110 29481965
Endophthalmitis 16.79 11.06 22 48430 2826 29523249
Product adhesion issue 16.70 11.06 16 48436 1455 29524620
Physical assault 16.68 11.06 14 48438 1070 29525005
Wrong product administered 16.60 11.06 28 48424 4503 29521572
Nausea 16.49 11.06 355 48097 288900 29237175
Substance-induced mood disorder 16.26 11.06 6 48446 86 29525989
Injection site ulcer 16.19 11.06 8 48444 242 29525833
Aqueous fibrin 16.16 11.06 5 48447 40 29526035
Anal sphincter atony 16.13 11.06 6 48446 88 29525987
Pulmonary fibrosis 16.11 11.06 3 48449 15579 29510496
Vitreous disorder 16.07 11.06 6 48446 89 29525986
Abdominal discomfort 16.06 11.06 34 48418 47869 29478206
Pneumocystis jirovecii pneumonia 15.79 11.06 4 48448 16775 29509300
Trigemino-cardiac reflex 15.50 11.06 7 48445 172 29525903
Drug resistance 15.42 11.06 8 48444 21532 29504543
Pulse absent 15.40 11.06 29 48423 5084 29520991
Electrocardiogram T wave amplitude increased 15.35 11.06 5 48447 48 29526027
Toxicologic test abnormal 15.26 11.06 10 48442 523 29525552
Withdrawal syndrome 15.16 11.06 46 48406 10946 29515129
Administration site pain 15.14 11.06 7 48445 182 29525893
Drug level increased 15.14 11.06 66 48386 18721 29507354
Product preparation error 15.06 11.06 16 48436 1646 29524429
Myoclonus 15.01 11.06 52 48400 13257 29512818
Blood pressure fluctuation 14.83 11.06 7 48445 19887 29506188
Diabetic ketoacidosis 14.80 11.06 4 48448 16069 29510006
Transient ischaemic attack 14.75 11.06 10 48442 23260 29502815
Delayed recovery from anaesthesia 14.70 11.06 11 48441 712 29525363
Product dose omission issue 14.68 11.06 95 48357 96288 29429787
Gun shot wound 14.65 11.06 13 48439 1072 29525003
Bone marrow failure 14.64 11.06 14 48438 27435 29498640
Phaeochromocytoma crisis 14.58 11.06 5 48447 57 29526018
Disease recurrence 14.58 11.06 4 48448 15910 29510165
Retinal vasculitis 14.23 11.06 8 48444 316 29525759
Ear infection 14.22 11.06 37 48415 8063 29518012
Hypoxia 14.18 11.06 129 48323 47250 29478825
Somnambulism 14.05 11.06 20 48432 2778 29523297
Stress 14.02 11.06 71 48381 21419 29504656
Musculoskeletal stiffness 13.93 11.06 25 48427 37433 29488642
Suicidal behaviour 13.92 11.06 14 48438 1351 29524724
Hepatic function abnormal 13.90 11.06 27 48425 39232 29486843
Drug interaction 13.81 11.06 422 48030 196963 29329112
Vitreous floaters 13.78 11.06 21 48431 3100 29522975
Red blood cell count decreased 13.72 11.06 13 48439 25589 29500486
Haemoptysis 13.65 11.06 18 48434 30532 29495543
Postmortem blood drug level 13.53 11.06 6 48446 141 29525934
Blood ethanol 13.40 11.06 5 48447 74 29526001
Acute myocardial infarction 13.39 11.06 38 48414 48400 29477675
Feeling drunk 13.31 11.06 15 48437 1649 29524426
Tracheitis 13.29 11.06 10 48442 653 29525422
Brachial plexus injury 13.28 11.06 5 48447 76 29525999
Dyspepsia 13.21 11.06 18 48434 30107 29495968
Corneal opacity 13.18 11.06 9 48443 504 29525571
Cardiotoxicity 13.17 11.06 26 48426 4718 29521357
Administration related reaction 12.93 11.06 5 48447 82 29525993
Muscular weakness 12.90 11.06 55 48397 61997 29464078
Infusion site bruising 12.88 11.06 8 48444 381 29525694
Product administration error 12.88 11.06 52 48400 14258 29511817
Mobility decreased 12.79 11.06 14 48438 25766 29500309
Proteinuria 12.67 11.06 5 48447 15799 29510276
Myokymia 12.66 11.06 5 48447 87 29525988
Prostate cancer 12.51 11.06 14 48438 25513 29500562
Accidental poisoning 12.50 11.06 9 48443 549 29525526
Alcoholic liver disease 12.47 11.06 9 48443 551 29525524
Blood pressure systolic increased 12.45 11.06 6 48446 16839 29509236
Infusion site extravasation 12.37 11.06 20 48432 3107 29522968
Jaundice 12.35 11.06 18 48434 29278 29496797
Oesophageal obstruction 12.30 11.06 8 48444 413 29525662
Chemical poisoning 12.26 11.06 5 48447 95 29525980
Postmortem blood drug level abnormal 12.20 11.06 7 48445 288 29525787
Psychiatric disorder prophylaxis 12.14 11.06 4 48448 40 29526035
Bronchospasm 12.13 11.06 39 48413 9570 29516505
International normalised ratio increased 12.13 11.06 35 48417 44337 29481738
Septic shock 12.07 11.06 57 48395 62503 29463572
Infusion site swelling 11.89 11.06 15 48437 1855 29524220
Blindness 11.88 11.06 45 48407 11978 29514097
Hypertonia 11.88 11.06 22 48430 3807 29522268
Gastrointestinal haemorrhage 11.80 11.06 79 48373 79454 29446621
Phlebitis superficial 11.77 11.06 7 48445 308 29525767
Neuromuscular blockade 11.75 11.06 6 48446 195 29525880
Seizure 11.71 11.06 216 48236 92907 29433168
Drug hypersensitivity 11.69 11.06 65 48387 68341 29457734
Surgery 11.57 11.06 44 48408 11735 29514340
Ophthalmoplegia 11.51 11.06 14 48438 1668 29524407
Diaphragmatic paralysis 11.51 11.06 8 48444 461 29525614
Benzodiazepine drug level therapeutic 11.48 11.06 4 48448 48 29526027
Drug diversion 11.47 11.06 10 48442 805 29525270
Ascites 11.45 11.06 27 48425 36592 29489483
Chronic obstructive pulmonary disease 11.42 11.06 32 48420 40923 29485152
Haemodynamic instability 11.33 11.06 34 48418 8039 29518036
Hypoxic-ischaemic encephalopathy 11.32 11.06 23 48429 4261 29521814
Cluster headache 11.26 11.06 8 48444 478 29525597
Hyperkalaemia 11.23 11.06 57 48395 61335 29464740
Blood ethanol increased 11.18 11.06 8 48444 483 29525592
Myocardial stunning 11.07 11.06 3 48449 14 29526061
Alopecia 11.06 11.06 9 48443 19075 29507000

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5134.37 10.04 3508 92324 220906 64181994
Toxicity to various agents 4119.22 10.04 3754 92078 359759 64043141
Drug abuse 3583.32 10.04 2303 93529 130071 64272829
Cardio-respiratory arrest 1204.50 10.04 1067 94765 97326 64305574
Intentional overdose 885.03 10.04 864 94968 89080 64313820
Overdose 733.72 10.04 1037 94795 158529 64244371
Alcohol interaction 574.37 10.04 224 95608 4177 64398723
Cardiac arrest 562.06 10.04 899 94933 153165 64249735
Suspected suicide 463.85 10.04 236 95596 8418 64394482
Intentional product misuse 433.96 10.04 536 95296 71759 64331141
Alcohol abuse 371.47 10.04 169 95663 4683 64398217
Respiratory arrest 350.85 10.04 413 95419 52572 64350328
Local anaesthetic systemic toxicity 337.01 10.04 95 95737 590 64402310
Suicide attempt 330.92 10.04 465 95367 70542 64332358
Methaemoglobinaemia 328.31 10.04 150 95682 4198 64398702
Death 319.06 10.04 1489 94343 481216 63921684
Alcohol poisoning 303.18 10.04 141 95691 4114 64398786
Toxic anterior segment syndrome 300.19 10.04 119 95713 2320 64400580
Alcohol use 216.49 10.04 115 95717 4487 64398413
Substance abuse 209.88 10.04 145 95687 9147 64393753
Anaesthetic complication 197.95 10.04 90 95742 2489 64400411
Coma 187.52 10.04 407 95425 87208 64315692
Anaphylactic reaction 182.57 10.04 349 95483 68315 64334585
Diarrhoea 171.84 10.04 529 95303 722175 63680725
Incorrect route of product administration 168.26 10.04 190 95642 23108 64379792
Drug dependence 166.88 10.04 226 95606 33086 64369814
Exposure to toxic agent 162.86 10.04 106 95726 6053 64396847
Respiratory depression 148.94 10.04 179 95653 23264 64379636
Anaphylactic shock 146.24 10.04 202 95630 30126 64372774
Arthralgia 138.14 10.04 281 95551 441979 63960921
Hypotension 135.54 10.04 999 94833 379975 64022925
Therapy interrupted 133.91 10.04 157 95675 19879 64383021
Unresponsive to stimuli 122.84 10.04 247 95585 50146 64352754
Joint swelling 116.12 10.04 90 95742 215292 64187608
Blood alcohol increased 115.87 10.04 49 95783 1133 64401767
Drug intolerance 114.07 10.04 69 95763 187923 64214977
Mydriasis 112.48 10.04 126 95706 15186 64387714
General physical health deterioration 112.02 10.04 84 95748 204341 64198559
Tachycardia 110.66 10.04 478 95354 149101 64253799
Poisoning deliberate 109.74 10.04 117 95715 13341 64389559
Synovitis 107.79 10.04 11 95821 99079 64303821
Fear 101.24 10.04 137 95695 20034 64382866
Generalised tonic-clonic seizure 100.31 10.04 198 95634 39659 64363241
Ventricular tachycardia 98.32 10.04 180 95652 34085 64368815
Aggression 96.85 10.04 213 95619 46019 64356881
Renal injury 93.43 10.04 115 95717 15314 64387586
Fatigue 88.15 10.04 702 95130 748028 63654872
Rheumatoid arthritis 83.14 10.04 73 95759 164221 64238679
Loss of consciousness 82.04 10.04 436 95396 147929 64254971
Agitation 81.01 10.04 302 95530 88065 64314835
Pulmonary oedema 80.75 10.04 279 95553 78395 64324505
Miosis 80.53 10.04 99 95733 13167 64389733
Abdominal discomfort 77.57 10.04 94 95738 182228 64220672
Poisoning 77.26 10.04 126 95706 21753 64381147
Pulseless electrical activity 77.22 10.04 95 95737 12644 64390256
Rash 77.02 10.04 385 95447 458164 63944736
Anhedonia 74.81 10.04 97 95735 13609 64389291
Asphyxia 74.20 10.04 81 95751 9485 64393415
Asthenia 73.25 10.04 357 95475 427687 63975213
Electrocardiogram QRS complex prolonged 72.97 10.04 79 95753 9165 64393735
Off label use 72.23 10.04 598 95234 632208 63770692
Pemphigus 70.77 10.04 5 95827 60696 64342204
Sinus tachycardia 70.49 10.04 151 95681 32037 64370863
Bradycardia 69.20 10.04 353 95479 117866 64285034
Anaemia 68.80 10.04 309 95523 378371 64024529
Corneal oedema 68.58 10.04 43 95789 2300 64400600
Systemic lupus erythematosus 67.77 10.04 16 95816 77596 64325304
Dyspnoea 67.10 10.04 714 95118 717960 63684940
Ventricular fibrillation 66.76 10.04 124 95708 23736 64379164
Seizure 66.36 10.04 450 95382 166442 64236458
Nasopharyngitis 65.05 10.04 120 95712 195953 64206947
Anaesthetic complication neurological 65.01 10.04 26 95806 519 64402381
Maternal exposure during delivery 64.98 10.04 30 95802 860 64402040
Drug use disorder 64.78 10.04 61 95771 5993 64396907
Postmortem blood drug level abnormal 64.02 10.04 27 95805 620 64402280
Contraindicated product administered 63.41 10.04 41 95791 107788 64295112
Pericarditis 62.92 10.04 9 95823 62507 64340393
Injury 62.25 10.04 204 95628 55788 64347112
Alopecia 61.80 10.04 94 95738 165596 64237304
Arthropathy 60.88 10.04 54 95778 120913 64281987
Lagophthalmos 60.67 10.04 22 95810 332 64402568
Therapeutic product effect decreased 59.87 10.04 50 95782 115301 64287599
Neutropenia 59.81 10.04 171 95661 239453 64163447
Accidental overdose 59.70 10.04 145 95687 33412 64369488
Extradural abscess 59.54 10.04 31 95801 1160 64401740
Intentional product use issue 57.38 10.04 287 95545 95077 64307823
Glossodynia 57.15 10.04 13 95819 64683 64338217
Body tinea 57.14 10.04 31 95801 1262 64401638
Emotional distress 57.08 10.04 149 95683 35889 64367011
Shock 56.42 10.04 154 95678 38086 64364814
Disease progression 56.16 10.04 77 95755 141603 64261297
Hepatic enzyme increased 55.24 10.04 67 95765 129876 64273024
Accidental death 54.85 10.04 45 95787 3680 64399220
Cough 54.57 10.04 247 95585 301901 64100999
Malaise 54.45 10.04 355 95477 395892 64007008
Decreased appetite 54.43 10.04 224 95608 281065 64121835
Unevaluable event 54.38 10.04 182 95650 50307 64352593
Pulse absent 53.07 10.04 66 95766 8880 64394020
Depressed level of consciousness 52.51 10.04 250 95582 81186 64321714
Electrocardiogram ST segment elevation 52.06 10.04 59 95773 7200 64395700
Acute kidney injury 51.39 10.04 424 95408 448816 63954084
Infusion related reaction 50.77 10.04 105 95727 164362 64238538
Weight decreased 50.16 10.04 236 95596 285503 64117397
Alcoholism 49.73 10.04 41 95791 3376 64399524
Pain in extremity 49.37 10.04 257 95575 302828 64100072
Procedural hypotension 48.74 10.04 32 95800 1854 64401046
Interstitial lung disease 48.73 10.04 44 95788 97688 64305212
Metabolic acidosis 47.33 10.04 220 95612 70738 64332162
Mobility decreased 47.33 10.04 35 95797 85805 64317095
Extradural haematoma 47.30 10.04 36 95796 2640 64400260
Somnolence 47.06 10.04 486 95346 203159 64199741
Pyrexia 46.17 10.04 570 95262 558074 63844826
Cardiac failure congestive 45.93 10.04 77 95755 130503 64272397
Drug hypersensitivity 45.61 10.04 190 95642 237625 64165275
Product adhesion issue 45.50 10.04 34 95798 2425 64400475
Helicobacter infection 45.18 10.04 3 95829 38359 64364541
Drug reaction with eosinophilia and systemic symptoms 43.87 10.04 13 95819 54204 64348696
Retinal vasculitis 43.85 10.04 25 95807 1122 64401778
Abdominal pain 43.31 10.04 279 95553 312096 64090804
Removal of foreign body 42.36 10.04 10 95822 26 64402874
Condition aggravated 42.33 10.04 352 95480 372074 64030826
Musculoskeletal stiffness 41.20 10.04 75 95757 123131 64279769
Homicide 41.11 10.04 24 95808 1127 64401773
Apnoea 40.90 10.04 63 95769 10359 64392541
Hypopyon 40.88 10.04 23 95809 1006 64401894
Respiratory acidosis 40.70 10.04 61 95771 9794 64393106
Alcohol withdrawal syndrome 40.39 10.04 28 95804 1775 64401125
Peripheral swelling 40.16 10.04 167 95665 208986 64193914
Drug interaction 40.12 10.04 758 95074 361325 64041575
Anterior chamber cell 39.91 10.04 21 95811 803 64402097
Abdominal pain upper 38.64 10.04 132 95700 174898 64228002
Drug screen positive 38.45 10.04 45 95787 5684 64397216
Arthritis 38.02 10.04 41 95791 83773 64319127
Hypoxia 37.61 10.04 242 95590 87907 64314993
Circulatory collapse 37.57 10.04 123 95709 33609 64369291
Aqueous fibrin 37.48 10.04 12 95820 121 64402779
Drug level increased 37.47 10.04 124 95708 34072 64368828
Thrombocytopenia 37.42 10.04 188 95644 223613 64179287
Pancytopenia 37.42 10.04 100 95732 143209 64259691
Swelling 37.31 10.04 118 95714 160100 64242800
Vitritis 37.17 10.04 25 95807 1508 64401392
Mental status changes 36.72 10.04 184 95648 60978 64341922
Fear of eating 36.72 10.04 16 95816 399 64402501
Nausea 36.65 10.04 889 94943 784911 63617989
Drug abuser 36.31 10.04 44 95788 5764 64397136
Wound 36.28 10.04 36 95796 76441 64326459
Infection susceptibility increased 36.15 10.04 31 95801 2695 64400205
Pruritus 36.06 10.04 294 95538 312106 64090794
Lower respiratory tract infection 35.92 10.04 53 95779 94561 64308339
Opiates positive 35.48 10.04 20 95812 878 64402022
Leukopenia 35.32 10.04 60 95772 101182 64301718
Malignant neoplasm progression 34.87 10.04 72 95760 112799 64290101
Medication error 34.86 10.04 157 95675 49809 64353091
Brain oedema 34.68 10.04 91 95741 21984 64380916
Endophthalmitis 34.12 10.04 41 95791 5324 64397576
Therapy cessation 34.00 10.04 116 95716 32373 64370527
Trigemino-cardiac reflex 33.90 10.04 13 95819 231 64402669
Haemoglobin decreased 33.68 10.04 162 95670 194901 64207999
Intentional self-injury 33.34 10.04 107 95725 28937 64373963
Postmortem blood drug level 32.81 10.04 13 95819 253 64402647
Road traffic accident 32.37 10.04 110 95722 30635 64372265
Ophthalmoplegia 32.36 10.04 29 95803 2673 64400227
Tryptase increased 31.95 10.04 15 95817 447 64402453
Cauda equina syndrome 31.68 10.04 20 95812 1083 64401817
Agranulocytosis 31.23 10.04 9 95823 38220 64364680
Oculocardiac reflex 31.12 10.04 9 95823 62 64402838
Folliculitis 31.04 10.04 4 95828 30073 64372827
Stress cardiomyopathy 30.92 10.04 52 95780 9205 64393695
Haematochezia 30.62 10.04 32 95800 66341 64336559
Gastrointestinal disorder 30.53 10.04 54 95778 89655 64313245
Cyanosis 30.49 10.04 87 95745 22068 64380832
Anal sphincter atony 30.29 10.04 13 95819 312 64402588
Hyponatraemia 30.00 10.04 116 95716 148223 64254677
Surgery 29.76 10.04 101 95731 28112 64374788
White blood cell count decreased 29.68 10.04 127 95705 157710 64245190
Drug ineffective 29.64 10.04 988 94844 839259 63563641
Myocardial fibrosis 29.58 10.04 22 95810 1558 64401342
Blood ethanol 29.29 10.04 10 95822 125 64402775
Impaired healing 29.22 10.04 28 95804 60445 64342455
Corneal epithelium defect 29.10 10.04 16 95816 669 64402231
Nystagmus 29.05 10.04 50 95782 9018 64393882
Spinal cord infarction 28.86 10.04 15 95817 559 64402341
Weight increased 28.31 10.04 193 95639 213155 64189745
Fall 28.06 10.04 443 95389 416383 63986517
Oedema peripheral 28.03 10.04 190 95642 210127 64192773
Product administration error 27.45 10.04 97 95735 27546 64375354
Pneumonia 27.42 10.04 628 95204 558948 63843952
Suicidal ideation 27.36 10.04 181 95651 66361 64336539
Drug withdrawal syndrome 27.05 10.04 105 95727 31186 64371714
Inhibitory drug interaction 26.90 10.04 30 95802 3597 64399303
Platelet count decreased 26.83 10.04 143 95689 167568 64235332
Myocardial infarction 26.74 10.04 141 95691 165680 64237220
Diabetes mellitus 26.46 10.04 36 95796 66438 64336462
Muscle injury 26.15 10.04 4 95828 26433 64376467
Neurotoxicity 25.38 10.04 94 95738 27310 64375590
Dysarthria 25.28 10.04 163 95669 59243 64343657
Impaired quality of life 25.23 10.04 39 95793 6432 64396468
Meningitis chemical 25.17 10.04 10 95822 196 64402704
Blood pressure fluctuation 25.09 10.04 24 95808 51847 64351053
Embolia cutis medicamentosa 25.08 10.04 13 95819 482 64402418
Blood creatinine increased 25.07 10.04 110 95722 135672 64267228
Sensory loss 24.95 10.04 50 95782 10119 64392781
Incorrect drug administration rate 24.61 10.04 25 95807 2694 64400206
Product preparation error 24.49 10.04 30 95802 3975 64398925
Platelet aggregation inhibition 24.45 10.04 9 95823 142 64402758
Pupil fixed 24.43 10.04 27 95805 3205 64399695
Loss of personal independence in daily activities 24.31 10.04 44 95788 72410 64330490
Blood ethanol increased 24.24 10.04 14 95818 644 64402256
Chemical submission 24.19 10.04 10 95822 218 64402682
Status epilepticus 24.13 10.04 79 95753 21584 64381316
Drug resistance 24.04 10.04 11 95821 35091 64367809
Type I hypersensitivity 23.87 10.04 28 95804 3546 64399354
Amphetamines positive 23.65 10.04 10 95822 231 64402669
Delayed recovery from anaesthesia 23.64 10.04 19 95813 1509 64401391
Septic shock 23.61 10.04 79 95753 105358 64297542
Pneumocephalus 23.50 10.04 10 95822 235 64402665
C-reactive protein increased 23.45 10.04 68 95764 94841 64308059
Cardiotoxicity 23.42 10.04 49 95783 10225 64392675
Melaena 23.40 10.04 27 95805 53521 64349379
Orthostatic hypotension 23.34 10.04 21 95811 46717 64356183
Parophthalmia 23.30 10.04 11 95821 332 64402568
Bronchospasm 23.20 10.04 78 95754 21604 64381296
Dehydration 23.19 10.04 208 95624 216555 64186345
Punctate keratitis 23.14 10.04 15 95817 850 64402050
Bursitis infective 23.12 10.04 17 95815 1183 64401717
Hypersensitivity 23.05 10.04 184 95648 196268 64206632
Toxicologic test abnormal 22.81 10.04 17 95815 1208 64401692
Cardiac failure 22.80 10.04 110 95722 132263 64270637
Pulmonary embolism 22.74 10.04 126 95706 146230 64256670
Wrong product administered 22.70 10.04 41 95791 7679 64395221
Anxiety 22.66 10.04 425 95407 202224 64200676
Spinal anaesthesia 22.47 10.04 7 95825 64 64402836
Upper airway obstruction 22.40 10.04 17 95815 1241 64401659
Kounis syndrome 22.40 10.04 25 95807 3000 64399900
Nerve root injury 22.37 10.04 6 95826 30 64402870
Bone marrow failure 22.25 10.04 23 95809 47929 64354971
Psoriatic arthropathy 22.15 10.04 19 95813 43262 64359638
Serotonin syndrome 22.06 10.04 116 95716 39166 64363734
Cytomegalovirus infection 22.06 10.04 14 95818 37185 64365715
Peripheral nerve injury 22.03 10.04 13 95819 623 64402277
Behaviour disorder 21.92 10.04 30 95802 4432 64398468
Psoriasis 21.92 10.04 46 95786 71657 64331243
Hyperkalaemia 21.81 10.04 77 95755 101052 64301848
Alcohol intolerance 21.75 10.04 11 95821 387 64402513
Pneumocystis jirovecii pneumonia 21.68 10.04 7 95825 27627 64375273
Victim of sexual abuse 21.52 10.04 11 95821 396 64402504
Amnesia 21.50 10.04 134 95698 48135 64354765
Neuromuscular block prolonged 21.48 10.04 15 95817 962 64401938
Treatment failure 21.34 10.04 95 95737 116721 64286179
Bezoar 21.31 10.04 21 95811 2182 64400718
Atonic urinary bladder 21.07 10.04 7 95825 80 64402820
Headache 20.92 10.04 613 95219 528854 63874046
Therapeutic product effect incomplete 20.87 10.04 81 95751 103401 64299499
Gastrointestinal haemorrhage 20.50 10.04 114 95718 132198 64270702
Blood pressure systolic increased 20.48 10.04 26 95806 49427 64353473
Product contamination microbial 20.46 10.04 14 95818 869 64402031
Withdrawal syndrome 20.45 10.04 79 95753 23413 64379487
Pupillary reflex impaired 20.40 10.04 24 95808 3049 64399851
Eosinophilia 20.38 10.04 16 95816 38060 64364840
Asthma 20.20 10.04 73 95759 95152 64307748
Liver disorder 20.13 10.04 30 95802 53321 64349579
Glucose tolerance impaired 19.95 10.04 35 95797 6408 64396492
Disease recurrence 19.89 10.04 11 95821 31499 64371401
Hepatic function abnormal 19.88 10.04 41 95791 64272 64338628
Substance dependence 19.60 10.04 11 95821 479 64402421
Ventricular extrasystoles 19.59 10.04 64 95768 17465 64385435
Hepatocellular injury 19.56 10.04 23 95809 45212 64357688
Underdose 19.47 10.04 7 95825 25822 64377078
Angina pectoris 19.41 10.04 23 95809 45058 64357842
Protein C increased 19.40 10.04 7 95825 104 64402796
Sensorimotor disorder 19.39 10.04 13 95819 780 64402120
Nasal congestion 19.33 10.04 37 95795 59621 64343279
Gastroenteritis 19.30 10.04 10 95822 29701 64373199
Cholestasis 19.20 10.04 23 95809 44849 64358051
Harlequin syndrome 19.06 10.04 6 95826 57 64402843
Electrocardiogram QT prolonged 18.98 10.04 191 95641 79257 64323643
Glossoptosis 18.88 10.04 8 95824 186 64402714
Multiple sclerosis relapse 18.79 10.04 20 95812 41115 64361785
Myelosuppression 18.76 10.04 6 95826 23824 64379076
Infusion site swelling 18.65 10.04 31 95801 5434 64397466
Product prescribing error 18.65 10.04 15 95817 35254 64367646
Type 2 diabetes mellitus 18.58 10.04 14 95818 34006 64368894
Peritonitis 18.50 10.04 7 95825 25016 64377884
Hepatic fibrosis 18.29 10.04 31 95801 5521 64397379
Tracheal deviation 18.27 10.04 6 95826 66 64402834
Pulmonary fibrosis 18.05 10.04 11 95821 29867 64373033
Blister 17.89 10.04 61 95771 80906 64321994
Cardiogenic shock 17.69 10.04 95 95737 32332 64370568
Phrenic nerve paralysis 17.63 10.04 8 95824 220 64402680
Restlessness 17.44 10.04 110 95722 39675 64363225
Arthritis bacterial 17.42 10.04 37 95795 7802 64395098
Catecholamine crisis 17.35 10.04 5 95827 34 64402866
Spinal epidural haemorrhage 17.17 10.04 7 95825 147 64402753
Brain death 17.17 10.04 28 95804 4833 64398067
Intracranial hypotension 17.04 10.04 9 95823 347 64402553
Foreign body in respiratory tract 17.04 10.04 9 95823 347 64402553
Lung disorder 16.88 10.04 41 95791 60659 64342241
Myoclonus 16.83 10.04 78 95754 25040 64377860
Substance use disorder 16.78 10.04 9 95823 358 64402542
Balance disorder 16.72 10.04 66 95766 83860 64319040
Infusion site pruritus 16.71 10.04 20 95812 2586 64400314
Impaired driving ability 16.70 10.04 27 95805 4627 64398273
Coronary artery disease 16.66 10.04 41 95791 60392 64342508
Retinal artery occlusion 16.55 10.04 21 95811 2882 64400018
Osteonecrosis of jaw 16.43 10.04 21 95811 39804 64363096
Neutropenic sepsis 16.40 10.04 7 95825 23265 64379635
Application site alopecia 16.29 10.04 4 95828 13 64402887
Axillary nerve injury 16.29 10.04 4 95828 13 64402887
Blood cholesterol increased 16.26 10.04 31 95801 50035 64352865
Hypocalcaemia 16.22 10.04 23 95809 41730 64361170
Spinal epidural haematoma 16.22 10.04 14 95818 1228 64401672
Somnambulism 16.01 10.04 28 95804 5113 64397787
Delirium 15.89 10.04 165 95667 69029 64333871
Foreign body 15.86 10.04 19 95813 2460 64400440
Influenza 15.85 10.04 93 95739 106438 64296462
Hypercalcaemia 15.82 10.04 14 95818 31402 64371498
Stridor 15.78 10.04 27 95805 4847 64398053
Neuropathy peripheral 15.73 10.04 106 95726 117419 64285481
Induced abortion failed 15.72 10.04 7 95825 184 64402716
Euphoric mood 15.69 10.04 32 95800 6559 64396341
Red blood cell count decreased 15.68 10.04 30 95802 48356 64354544
Red blood cell sedimentation rate increased 15.64 10.04 14 95818 31221 64371679
Stomatitis 15.62 10.04 97 95735 109508 64293392
Neoplasm progression 15.49 10.04 23 95809 40941 64361959
Ill-defined disorder 15.46 10.04 26 95806 44026 64358874
Paralysis 15.44 10.04 45 95787 11550 64391350
Brachial plexus injury 15.42 10.04 6 95826 111 64402789
Diabetic ketoacidosis 15.40 10.04 13 95819 29832 64373068
Haemodynamic instability 15.39 10.04 53 95779 14859 64388041
Substance-induced mood disorder 15.32 10.04 6 95826 113 64402787
Stevens-Johnson syndrome 15.25 10.04 17 95815 34232 64368668
Anaphylactoid shock 15.25 10.04 11 95821 743 64402157
Inappropriate antidiuretic hormone secretion 15.24 10.04 7 95825 22282 64380618
Injection site bruising 15.19 10.04 19 95813 36354 64366546
Chest pain 15.11 10.04 253 95579 235727 64167173
Lymphadenopathy 15.08 10.04 29 95803 46657 64356243
Chemical burn 14.94 10.04 9 95823 448 64402452
Jaundice 14.93 10.04 31 95801 48481 64354419
Trigeminal palsy 14.92 10.04 4 95828 20 64402880
Incision site rash 14.92 10.04 4 95828 20 64402880
Post procedural complication 14.82 10.04 67 95765 21286 64381614
Nail bed tenderness 14.74 10.04 8 95824 326 64402574
Infection 14.69 10.04 190 95642 184690 64218210
Dyspnoea exertional 14.68 10.04 58 95774 73672 64329228
Transient ischaemic attack 14.67 10.04 27 95805 44155 64358745
Brain injury 14.56 10.04 40 95792 9925 64392975
Osteoarthritis 14.49 10.04 47 95785 63289 64339611
Mean arterial pressure decreased 14.41 10.04 8 95824 341 64402559
Accidental poisoning 14.33 10.04 14 95818 1439 64401461
Spinal cord oedema 14.30 10.04 8 95824 346 64402554
Ventricular hypokinesia 14.28 10.04 34 95798 7735 64395165
Injection site reaction 14.21 10.04 30 95802 46634 64356266
Intentional dose omission 14.12 10.04 28 95804 5624 64397276
Dizziness 14.11 10.04 510 95322 429653 63973247
Injection site ulcer 14.11 10.04 10 95822 657 64402243
Opisthotonus 14.05 10.04 10 95822 661 64402239
Inappropriate schedule of product administration 14.03 10.04 80 95752 92206 64310694
Gait disturbance 14.02 10.04 176 95656 171979 64230921
Neuromuscular blockade 13.97 10.04 9 95823 505 64402395
Vitreous disorder 13.93 10.04 7 95825 243 64402657
Angina unstable 13.88 10.04 3 95829 15464 64387436
Nerve block 13.87 10.04 8 95824 367 64402533
Gastrooesophageal reflux disease 13.79 10.04 70 95762 83073 64319827
Oxidative stress 13.78 10.04 4 95828 28 64402872
Foetal heart rate abnormal 13.77 10.04 7 95825 249 64402651
Blindness 13.75 10.04 67 95765 21952 64380948
Anaphylactoid reaction 13.72 10.04 25 95807 4713 64398187
Accident 13.72 10.04 31 95801 6815 64396085
Body dysmorphic disorder 13.69 10.04 7 95825 252 64402648
Abdominal distension 13.65 10.04 85 95747 95909 64306991
Familial periodic paralysis 13.64 10.04 6 95826 153 64402747
Infusion site erythema 13.64 10.04 31 95801 6842 64396058
Physical assault 13.60 10.04 14 95818 1532 64401368
Gastric disorder 13.55 10.04 14 95818 29183 64373717
Injection site joint infection 13.54 10.04 4 95828 30 64402870
Anal ulcer 13.47 10.04 12 95820 1097 64401803
Poor quality product administered 13.42 10.04 20 95812 3195 64399705
Prescribed underdose 13.38 10.04 5 95827 18010 64384890
Skin lesion 13.30 10.04 21 95811 36461 64366439
Cholestasis of pregnancy 13.25 10.04 11 95821 914 64401986
Adverse event 13.23 10.04 24 95808 39465 64363435
Product use issue 13.16 10.04 153 95679 151562 64251338
Visual acuity reduced 13.14 10.04 77 95755 27064 64375836
Apnoeic attack 13.10 10.04 9 95823 562 64402338
Pulmonary congestion 13.05 10.04 70 95762 23810 64379090
Deep vein thrombosis 13.04 10.04 97 95735 105085 64297815
Gastritis alcoholic 13.00 10.04 4 95828 35 64402865
Symblepharon 12.96 10.04 6 95826 173 64402727
COVID-19 immunisation 12.96 10.04 9 95823 572 64402328
International normalised ratio increased 12.93 10.04 67 95765 79100 64323800
Abortion spontaneous 12.91 10.04 11 95821 25132 64377768
Reperfusion arrhythmia 12.90 10.04 7 95825 285 64402615
Metastases to liver 12.89 10.04 10 95822 23931 64378969
Ascites 12.84 10.04 48 95784 61953 64340947
Hypoxic-ischaemic encephalopathy 12.82 10.04 31 95801 7121 64395779
Lung neoplasm malignant 12.81 10.04 8 95824 21440 64381460
Alcoholic 12.80 10.04 4 95828 37 64402863
Constipation 12.76 10.04 252 95580 229085 64173815
Skin exfoliation 12.73 10.04 30 95802 44855 64358045
Infusion site mass 12.69 10.04 11 95821 970 64401930
Femoral nerve injury 12.52 10.04 4 95828 40 64402860
Psychiatric disorder prophylaxis 12.52 10.04 4 95828 40 64402860
Abnormal sleep-related event 12.35 10.04 10 95822 803 64402097
Left ventricle outflow tract obstruction 12.32 10.04 7 95825 312 64402588
Irritable bowel syndrome 12.26 10.04 23 95809 37346 64365554
Accidental exposure to product 12.25 10.04 74 95758 26290 64376610
Progressive multifocal leukoencephalopathy 12.05 10.04 6 95826 18226 64384674
Airway peak pressure increased 11.96 10.04 7 95825 330 64402570
Full blood count abnormal 11.95 10.04 16 95816 29741 64373159
Myelodysplastic syndrome 11.95 10.04 14 95818 27565 64375335
Infusion site bruising 11.93 10.04 13 95819 1519 64401381
Myokymia 11.93 10.04 5 95827 113 64402787
Eczema 11.92 10.04 16 95816 29704 64373196
Benzodiazepine drug level therapeutic 11.87 10.04 4 95828 48 64402852
Obesity 11.83 10.04 8 95824 20554 64382346
Paranasal cyst 11.83 10.04 7 95825 337 64402563
Discomfort 11.82 10.04 71 95761 80807 64322093
Non-cardiogenic pulmonary oedema 11.79 10.04 12 95820 1296 64401604
Graft versus host disease 11.76 10.04 3 95829 13810 64389090
Pain in jaw 11.75 10.04 27 95805 40728 64362172
Vascular resistance systemic decreased 11.74 10.04 6 95826 216 64402684
Blood lactic acid increased 11.65 10.04 38 95794 10363 64392537
Cardiac death 11.64 10.04 12 95820 1316 64401584
Stab wound 11.61 10.04 6 95826 221 64402679
Congestive hepatopathy 11.55 10.04 21 95811 3952 64398948
Areflexia 11.55 10.04 24 95808 4983 64397917
Bundle branch block left 11.54 10.04 37 95795 9997 64392903
Inadequate analgesia 11.54 10.04 21 95811 3957 64398943
Procedural complication 11.46 10.04 30 95802 7235 64395665
Administration related reaction 11.43 10.04 5 95827 126 64402774
Corneal opacity 11.41 10.04 10 95822 895 64402005
Acute myocardial infarction 11.39 10.04 59 95773 69659 64333241
Poor quality sleep 11.36 10.04 57 95775 18894 64384006
Diabetes mellitus inadequate control 11.36 10.04 9 95823 21312 64381588
Chest discomfort 11.30 10.04 114 95718 115992 64286908
Osteoporosis 11.25 10.04 29 95803 42051 64360849
Drug eruption 11.20 10.04 23 95809 36113 64366787
Coccygectomy 11.19 10.04 3 95829 15 64402885
Sinus arrest 11.19 10.04 18 95814 3072 64399828
Myalgia 11.17 10.04 167 95665 158450 64244450
Immunodeficiency 11.13 10.04 5 95827 16119 64386781
Sinus bradycardia 11.11 10.04 65 95767 22828 64380072
Feeling abnormal 11.10 10.04 136 95696 133466 64269434
Acute pulmonary oedema 11.08 10.04 43 95789 12766 64390134
Glycosylated haemoglobin increased 11.00 10.04 5 95827 16014 64386886
Cerebral haemorrhage 10.94 10.04 39 95793 51051 64351849
Fatty liver alcoholic 10.93 10.04 4 95828 62 64402838
Paraplegia 10.92 10.04 22 95810 4468 64398432
Rash pruritic 10.90 10.04 46 95786 57358 64345542
Infusion site nodule 10.89 10.04 6 95826 252 64402648
Throat irritation 10.85 10.04 20 95812 32691 64370209
Palpitations 10.84 10.04 101 95731 104387 64298513
Postmortem blood drug level increased 10.80 10.04 9 95823 752 64402148
Repetitive strain injury 10.74 10.04 5 95827 146 64402754
Gait inability 10.72 10.04 30 95802 42338 64360562
Suicidal behaviour 10.70 10.04 17 95815 2870 64400030
Air embolism 10.67 10.04 7 95825 405 64402495
Renal impairment 10.63 10.04 139 95693 134878 64268022
Sopor 10.61 10.04 78 95754 29583 64373317
Haematotoxicity 10.60 10.04 3 95829 12893 64390007
Infusion site extravasation 10.55 10.04 28 95804 6809 64396091
Procedural haemorrhage 10.54 10.04 21 95811 4231 64398669
Orbital infection 10.49 10.04 4 95828 70 64402830
Gastric ulcer 10.46 10.04 18 95814 30216 64372684
Suspected suicide attempt 10.45 10.04 6 95826 273 64402627
Upper gastrointestinal haemorrhage 10.43 10.04 23 95809 35197 64367703
Breast cancer 10.42 10.04 17 95815 29131 64373769
Irregular breathing 10.38 10.04 7 95825 424 64402476
Full blood count decreased 10.29 10.04 11 95821 22571 64380329
Anticholinergic syndrome 10.29 10.04 16 95816 2653 64400247
Hypercholesterolaemia 10.25 10.04 5 95827 15368 64387532
Cholelithiasis 10.25 10.04 34 95798 45472 64357428
Oesophageal obstruction 10.23 10.04 9 95823 810 64402090
Chemical poisoning 10.21 10.04 5 95827 164 64402736
Amaurosis 10.19 10.04 10 95822 1034 64401866
Coma scale abnormal 10.19 10.04 30 95802 7744 64395156
Hip arthroplasty 10.18 10.04 10 95822 21341 64381559
Tubulointerstitial nephritis 10.16 10.04 19 95813 30890 64372010
Tracheitis 10.14 10.04 11 95821 1279 64401621
Metastases to lung 10.12 10.04 5 95827 15259 64387641
Immune reconstitution inflammatory syndrome 10.07 10.04 3 95829 12467 64390433
Oropharyngeal pain 10.06 10.04 84 95748 88783 64314117
Alcoholic pancreatitis 10.04 10.04 5 95827 170 64402730

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 55.01 20.06 9 4 68 84597

Pharmacologic Action:

SourceCodeDescription
ATC D08AJ01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA05 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC D09AA11 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA16 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
CHEBI has role CHEBI:27780 Detergents
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35195 surfactant
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D010592 Pharmaceutic Aids
MeSH PA D011310 Preservatives, Pharmaceutical
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:51076 Marine pesticide

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Uveitis indication 128473001 DOID:13141
Skin irritation indication 367466007
Local anesthesia indication 386761002
Allergic otitis externa indication 405821001
Itching of skin indication 418363000
Itching of ear indication 699392007
Post-Op Ocular Inflammation indication
Suppression of the Gag Reflex indication
Mouth Irritation indication
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Bacterial septicemia contraindication 10001005 DOID:0040085
Hypocupremia contraindication 19577007
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Shock contraindication 27942005
Methemoglobinemia contraindication 38959009 DOID:10783
Conduction disorder of the heart contraindication 44808001
Perforation of tympanic membrane contraindication 60442001
Diabetes mellitus contraindication 73211009 DOID:9351
Decreased respiratory function contraindication 80954004
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Peripheral vascular disease contraindication 400047006
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018249 VUID
N0000178890 NUI
D00857 KEGG_DRUG
8001-54-5 SECONDARY_CAS_RN
4018249 VANDF
4023321 VANDF
C0005025 UMLSCUI
CHEBI:3020 CHEBI
CHEMBL1187417 ChEMBL_ID
CHEMBL502109 ChEMBL_ID
CHEMBL1907001 ChEMBL_ID
D001548 MESH_DESCRIPTOR_UI
DB11105 DRUGBANK_ID
7N6JUD5X6Y UNII
2330 PUBCHEM_CID
DB13282 DRUGBANK_ID
1311593 RXNORM
4255 MMSL
5003 MMSL
003141 NDDF
005466 NDDF
006369 NDDF
373549009 SNOMEDCT_US
64686009 SNOMEDCT_US
735078001 SNOMEDCT_US
90370005 SNOMEDCT_US
1168 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Stay Safe Hand Sanitizer Alcohol Free HUMAN OTC DRUG LABEL 1 0295-9049 GEL 0.13 mg TOPICAL OTC monograph not final 10 sections
Hand wash HUMAN OTC DRUG LABEL 1 0363-0082 SOAP 1.30 mg TOPICAL OTC monograph not final 11 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-0242 SOAP 130 mg TOPICAL OTC monograph not final 12 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Nicefresh scent HUMAN OTC DRUG LABEL 1 0363-0554 CLOTH 0.12 g TOPICAL OTC monograph not final 11 sections
First Aid Antiseptic Wipes HUMAN OTC DRUG LABEL 1 0363-0589 CLOTH 0.00 mg TOPICAL OTC monograph not final 11 sections
First Aid Antiseptic Wipes HUMAN OTC DRUG LABEL 1 0363-0589 CLOTH 0.00 mg TOPICAL OTC monograph not final 11 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.13 g ORAL OTC monograph not final 9 sections
Hand wipes HUMAN OTC DRUG LABEL 1 0363-0644 CLOTH 1.30 g TOPICAL OTC monograph not final 12 sections
Hand wipes HUMAN OTC DRUG LABEL 1 0363-0644 CLOTH 1.30 g TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0651 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0651 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0683 LIQUID 1.30 mg TOPICAL OTC monograph not final 11 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0683 LIQUID 1.30 mg TOPICAL OTC monograph not final 11 sections
First Aid AntisepticWell at Walgreens HUMAN OTC DRUG LABEL 2 0363-3286 SPRAY 0.13 g TOPICAL OTC monograph not final 11 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.13 g ORAL OTC monograph not final 9 sections
Walgreen Maximum strengthpain relieving cleansing HUMAN OTC DRUG LABEL 2 0363-7020 LIQUID 0.13 g TOPICAL OTC monograph not final 14 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0363-7110 LIQUID 1.25 g TOPICAL OTC monograph not final 11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL HUMAN OTC DRUG LABEL 1 0363-7210 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
WalgreensANTIBACTERIAL HAND REFILL HUMAN OTC DRUG LABEL 1 0363-7211 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
STUDIO 35AMBER HUMAN OTC DRUG LABEL 1 0363-7215 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Antiseptic Pain Relieving HUMAN OTC DRUG LABEL 2 0363-7779 SPRAY 0.10 g TOPICAL OTC monograph not final 7 sections
Walgreens HUMAN OTC DRUG LABEL 2 0363-7950 SPRAY 0.13 g TOPICAL OTC monograph not final 12 sections
Walgreens Fresh Antibacterial Foaming Hand HUMAN OTC DRUG LABEL 1 0363-9000 SOAP 1.30 mg TOPICAL OTC monograph not final 12 sections
Walgreens Citrus Antibacterial Foaming Hand HUMAN OTC DRUG LABEL 1 0363-9002 SOAP 1.30 mg TOPICAL OTC monograph not final 12 sections
HUMCO Merthiolate HUMAN OTC DRUG LABEL 1 0395-8010 LIQUID 1.30 mg TOPICAL OTC monograph not final 13 sections
HUMCO Merthiolate HUMAN OTC DRUG LABEL 1 0395-8010 LIQUID 1.30 mg TOPICAL OTC monograph not final 13 sections
Merthiolate HUMAN OTC DRUG LABEL 1 0395-9122 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0404-4445 LIQUID 7.49 g TOPICAL OTC monograph not final 11 sections