benzalkonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 3017 139-07-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzalkonium chloride
  • benzalkonium
  • benzyldodecyldimethylammonium chloride
  • benzododecinium
A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA:
  • ALOGS: -7.85
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3410.74 9.93 2268 87154 143405 63256195
Toxicity to various agents 2128.44 9.93 2149 87273 245101 63154499
Drug abuse 1129.35 9.93 884 88538 71634 63327966
Cardio-respiratory arrest 726.18 9.93 632 88790 59327 63340273
Intentional overdose 521.79 9.93 581 88841 73571 63326029
Local anaesthetic systemic toxicity 450.39 9.93 125 89297 774 63398826
Overdose 405.08 9.93 642 88780 114436 63285164
Cardiac arrest 383.34 9.93 557 88865 91988 63307612
Alcohol interaction 325.70 9.93 124 89298 2285 63397315
Suicide attempt 274.77 9.93 382 89040 60536 63339064
Suspected suicide 252.44 9.93 141 89281 6427 63393173
Pemphigus 223.31 9.93 8 89414 183718 63215882
Toxic anterior segment syndrome 217.46 9.93 85 89337 1686 63397914
Sinusitis 208.32 9.93 747 88675 225906 63173694
Glossodynia 194.94 9.93 15 89407 178861 63220739
Methaemoglobinaemia 192.41 9.93 85 89337 2318 63397282
Hand deformity 190.17 9.93 8 89414 159449 63240151
Respiratory arrest 184.83 9.93 229 89193 32416 63367184
Synovitis 179.73 9.93 25 89397 186893 63212707
Systemic lupus erythematosus 176.80 9.93 39 89383 208879 63190721
Alcohol poisoning 173.65 9.93 74 89348 1845 63397755
Infusion site pain 165.21 9.93 158 89264 16711 63382889
Alopecia 152.97 9.93 150 89272 337386 63062214
Death 152.11 9.93 974 88448 373407 63026193
Exposure to toxic agent 152.05 9.93 96 89326 5491 63394109
Anti-cyclic citrullinated peptide antibody positive 148.83 9.93 3 89419 116209 63283391
Infusion site extravasation 146.83 9.93 120 89302 10306 63389294
Abdominal discomfort 141.50 9.93 146 89276 320739 63078861
Intentional product misuse 139.57 9.93 282 89140 60635 63338965
Infusion site swelling 136.64 9.93 112 89310 9658 63389942
Alcohol use 133.28 9.93 63 89359 2016 63397584
Infusion site pruritus 133.28 9.93 91 89331 5944 63393656
Contraindicated product administered 130.55 9.93 72 89350 217576 63182024
Wound 129.28 9.93 35 89387 163228 63236372
Infusion site haemorrhage 127.53 9.93 83 89339 5003 63394597
COVID-19 126.97 9.93 399 89023 112704 63286896
Kounis syndrome 125.14 9.93 57 89365 1673 63397927
Pericarditis 123.20 9.93 19 89403 131560 63268040
Infusion site erythema 115.52 9.93 110 89312 11569 63388031
Maternal exposure during delivery 113.50 9.93 51 89371 1449 63398151
Drug intolerance 112.25 9.93 163 89259 308498 63091102
Joint swelling 111.53 9.93 181 89241 327485 63072115
Gastrointestinal toxicity 108.80 9.93 89 89333 7652 63391948
Hepatic enzyme increased 106.15 9.93 78 89344 202250 63197350
Drug ineffective 105.59 9.93 954 88468 1043811 62355789
Duodenal ulcer perforation 105.21 9.93 4 89418 87205 63312395
Rheumatoid factor positive 104.92 9.93 3 89419 84403 63315197
Alcohol abuse 104.71 9.93 54 89368 2092 63397508
Anaesthetic complication 103.44 9.93 52 89370 1908 63397692
Seasonal allergy 95.32 9.93 132 89290 20818 63378782
General physical health deterioration 90.56 9.93 90 89332 201312 63198288
Pulmonary toxicity 89.64 9.93 87 89335 9368 63390232
Mydriasis 87.97 9.93 96 89326 11860 63387740
Diarrhoea 87.85 9.93 619 88803 714747 62684853
Therapy interrupted 87.49 9.93 161 89261 32294 63367306
Anaphylactic reaction 86.26 9.93 246 89176 65854 63333746
Infusion site bruising 85.14 9.93 58 89364 3774 63395826
Generalised tonic-clonic seizure 84.68 9.93 149 89273 28867 63370733
Seizure 84.10 9.93 390 89032 132244 63267356
Swelling 82.11 9.93 165 89257 275213 63124387
Incorrect drug administration rate 81.05 9.93 57 89365 3905 63395695
Therapeutic product effect decreased 79.44 9.93 93 89329 193094 63206506
Anaphylactic shock 79.09 9.93 129 89293 23504 63376096
Rash 77.54 9.93 468 88954 560403 62839197
Pulseless electrical activity 76.60 9.93 72 89350 7449 63392151
Insurance issue 74.95 9.93 65 89357 6056 63393544
Folliculitis 73.54 9.93 7 89415 70310 63329290
Coma 73.04 9.93 228 89194 64136 63335464
Ear infection 69.30 9.93 161 89261 38052 63361548
Rheumatoid arthritis 65.91 9.93 164 89258 253655 63145945
Somnolence 65.75 9.93 454 88968 178231 63221369
Arthropathy 64.70 9.93 147 89275 234645 63164955
Agitation 64.44 9.93 208 89214 59549 63340051
Illness 63.43 9.93 182 89240 48877 63350723
Helicobacter infection 62.76 9.93 26 89396 92759 63306841
Arthralgia 61.76 9.93 510 88912 569200 62830400
Impaired healing 61.32 9.93 34 89388 102508 63297092
Poisoning deliberate 59.20 9.93 76 89346 11142 63388458
Blister 58.33 9.93 58 89364 129756 63269844
Discomfort 58.24 9.93 91 89331 167283 63232317
Loss of consciousness 57.80 9.93 323 89099 117798 63281802
Muscle injury 57.71 9.93 11 89411 65334 63334266
Corneal oedema 57.23 9.93 32 89390 1461 63398139
Bradycardia 56.89 9.93 229 89193 72998 63326602
Psoriatic arthropathy 56.70 9.93 29 89393 91491 63308109
Extradural abscess 55.82 9.93 27 89395 910 63398690
Postmortem blood drug level abnormal 54.12 9.93 20 89402 338 63399262
Upper respiratory tract infection 54.01 9.93 244 89178 81803 63317797
Alcoholism 53.92 9.93 33 89389 1785 63397815
Ventricular tachycardia 53.70 9.93 99 89323 19880 63379720
Infusion site urticaria 52.60 9.93 31 89391 1565 63398035
Infusion site mass 52.47 9.93 34 89388 2034 63397566
Unresponsive to stimuli 52.28 9.93 134 89288 33682 63365918
Anaesthetic complication neurological 52.21 9.93 18 89404 246 63399354
Blood alcohol increased 52.00 9.93 23 89399 629 63398971
Hypersensitivity 51.81 9.93 224 89198 292461 63107139
Product use issue 51.56 9.93 150 89272 220370 63179230
Tachycardia 51.26 9.93 313 89109 117843 63281757
Electrocardiogram ST segment elevation 50.72 9.93 43 89379 3884 63395716
Body tinea 50.32 9.93 32 89390 1853 63397747
Neoplasm malignant 50.02 9.93 122 89300 29739 63369861
Stress cardiomyopathy 49.83 9.93 64 89358 9386 63390214
Substance abuse 48.92 9.93 46 89376 4761 63394839
Hypotension 48.09 9.93 591 88831 272013 63127587
Procedural hypotension 46.96 9.93 26 89396 1164 63398436
Rheumatic fever 45.86 9.93 4 89418 43107 63356493
Asthenia 44.93 9.93 336 89086 383268 63016332
Victim of sexual abuse 44.68 9.93 21 89401 663 63398937
Incorrect route of product administration 43.70 9.93 110 89312 27342 63372258
Chemical submission 43.53 9.93 16 89406 266 63399334
Extradural haematoma 42.92 9.93 28 89394 1694 63397906
Pulse absent 42.79 9.93 45 89377 5329 63394271
Bronchitis 42.76 9.93 312 89110 124623 63274977
Systemic toxicity 42.73 9.93 12 89410 78 63399522
Respiratory tract infection 42.57 9.93 142 89280 41341 63358259
Joint injury 41.46 9.93 113 89309 29459 63370141
Off label use 41.36 9.93 685 88737 673777 62725823
Neutropenia 40.93 9.93 119 89303 174886 63224714
Poisoning 40.81 9.93 71 89351 13629 63385971
Stomatitis 40.55 9.93 84 89338 138641 63260959
Respiratory depression 39.46 9.93 70 89352 13645 63385955
Acute kidney injury 39.39 9.93 214 89208 263201 63136399
Lagophthalmos 39.31 9.93 16 89406 354 63399246
Mobility decreased 39.23 9.93 69 89353 121090 63278510
Infusion site rash 39.20 9.93 28 89394 1966 63397634
Urinary tract infection 38.84 9.93 555 88867 264129 63135471
Disease progression 37.88 9.93 72 89350 122686 63276914
Sinus tachycardia 37.34 9.93 96 89326 24172 63375428
Ventricular fibrillation 37.32 9.93 63 89359 11804 63387796
Myocarditis 36.79 9.93 58 89364 10267 63389333
Inhibitory drug interaction 36.40 9.93 31 89391 2818 63396782
Lower respiratory tract infection 36.28 9.93 83 89339 132224 63267376
Nystagmus 35.78 9.93 44 89378 6176 63393424
Loss of personal independence in daily activities 35.66 9.93 51 89371 97239 63302361
Hepatotoxicity 35.55 9.93 124 89298 36917 63362683
Mental status changes 34.97 9.93 129 89293 39470 63360130
Product adhesion issue 34.91 9.93 38 89384 4681 63394919
Pneumocephalus 34.54 9.93 12 89410 168 63399432
Hypopyon 34.51 9.93 18 89404 714 63398886
Apnoea 34.20 9.93 49 89373 7973 63391627
Staphylococcal infection 33.63 9.93 131 89291 41125 63358475
Abdominal pain upper 32.94 9.93 164 89258 206280 63193320
Multiple allergies 32.91 9.93 65 89357 13737 63385863
Dermatitis contact 32.72 9.93 57 89365 10951 63388649
Dyspnoea 32.66 9.93 697 88725 660616 62738984
Infection susceptibility increased 32.63 9.93 32 89390 3489 63396111
Peripheral swelling 32.52 9.93 230 89192 265712 63133888
Thrombocytopenia 32.35 9.93 107 89315 151050 63248550
Vitritis 31.99 9.93 19 89403 973 63398627
Kidney infection 31.93 9.93 88 89334 23088 63376512
Administration site pain 31.91 9.93 18 89404 836 63398764
Ill-defined disorder 31.84 9.93 41 89381 81714 63317886
Pain 31.71 9.93 798 88624 739830 62659770
Bursitis infective 31.44 9.93 21 89401 1322 63398278
Prescribed underdose 30.92 9.93 3 89419 29686 63369914
Embolia cutis medicamentosa 30.67 9.93 14 89408 413 63399187
Anterior chamber cell 30.38 9.93 15 89407 529 63399071
Fear 30.32 9.93 68 89354 15698 63383902
Corneal epithelium defect 29.96 9.93 13 89409 339 63399261
Drug use disorder 29.88 9.93 36 89386 4948 63394652
Infusion site nodule 29.44 9.93 21 89401 1471 63398129
Electrocardiogram QRS complex prolonged 29.42 9.93 39 89383 5899 63393701
Platelet aggregation inhibition 29.32 9.93 10 89412 132 63399468
Cauda equina syndrome 29.24 9.93 18 89404 984 63398616
Product administration interrupted 29.10 9.93 35 89387 4801 63394799
Purtscher retinopathy 28.74 9.93 9 89413 89 63399511
Fear of eating 28.62 9.93 13 89409 379 63399221
Aggression 28.29 9.93 85 89337 23413 63376187
Treatment failure 27.96 9.93 165 89257 198878 63200722
Parophthalmia 27.73 9.93 12 89410 311 63399289
Administration site swelling 27.19 9.93 19 89403 1288 63398312
Retinal vasculitis 27.16 9.93 17 89405 957 63398643
Unevaluable event 26.78 9.93 143 89279 51243 63348357
Endophthalmitis 26.70 9.93 29 89393 3563 63396037
Aqueous fibrin 26.52 9.93 8 89414 69 63399531
C-reactive protein increased 26.29 9.93 59 89363 94648 63304952
Drug interaction 26.23 9.93 461 88961 228670 63170930
Hyponatraemia 26.21 9.93 76 89346 111824 63287776
Drug dependence 26.18 9.93 85 89337 24398 63375202
COVID-19 immunisation 26.07 9.93 21 89401 1766 63397834
Surgery 26.06 9.93 110 89312 35802 63363798
Type I hypersensitivity 25.90 9.93 26 89396 2916 63396684
Fatigue 25.80 9.93 1007 88415 887021 62512579
Irritable bowel syndrome 25.72 9.93 48 89374 82364 63317236
Substance use disorder 25.64 9.93 10 89412 197 63399403
Cardiogenic shock 25.61 9.93 69 89353 17863 63381737
Status epilepticus 25.26 9.93 62 89360 15171 63384429
Anal skin tags 25.06 9.93 13 89409 510 63399090
Glucose tolerance impaired 24.91 9.93 38 89384 6539 63393061
Pancytopenia 24.83 9.93 63 89359 96870 63302730
Orthostatic hypotension 24.66 9.93 10 89412 36150 63363450
Renal injury 24.40 9.93 46 89376 9393 63390207
Hip arthroplasty 24.15 9.93 19 89403 47627 63351973
Peripheral nerve injury 23.90 9.93 12 89410 439 63399161
Type 2 diabetes mellitus 23.88 9.93 33 89389 63835 63335765
Product dose omission issue 23.88 9.93 463 88959 233850 63165750
Somnambulism 23.84 9.93 34 89388 5509 63394091
Cardiac failure congestive 23.74 9.93 60 89362 92373 63307227
Spinal epidural haemorrhage 23.71 9.93 8 89414 102 63399498
Abdominal pain 23.61 9.93 282 89140 293174 63106426
Septic arthritis staphylococcal 23.36 9.93 12 89410 461 63399139
Protein C increased 23.09 9.93 8 89414 111 63399489
Cyanosis 23.03 9.93 64 89358 16871 63382729
Pulmonary oedema 22.92 9.93 144 89278 54729 63344871
Drug level increased 22.59 9.93 77 89345 22659 63376941
Septic shock 22.43 9.93 37 89385 66592 63333008
Leukopenia 22.41 9.93 47 89375 77243 63322357
Congestive hepatopathy 22.30 9.93 24 89398 2918 63396682
Malignant neoplasm progression 22.12 9.93 52 89370 82069 63317531
Drug reaction with eosinophilia and systemic symptoms 22.05 9.93 10 89412 33826 63365774
Victim of chemical submission 22.03 9.93 12 89410 520 63399080
Anhedonia 21.86 9.93 48 89374 10926 63388674
Nerve root injury 21.50 9.93 6 89416 38 63399562
Upper airway obstruction 21.46 9.93 13 89409 690 63398910
Anaemia 21.35 9.93 288 89134 293142 63106458
Atonic urinary bladder 21.21 9.93 7 89415 83 63399517
Blood cholesterol increased 21.20 9.93 65 89357 93967 63305633
Infusion site discomfort 21.11 9.93 17 89405 1429 63398171
Drug withdrawal syndrome 21.07 9.93 85 89337 27109 63372491
Spinal anaesthesia 20.98 9.93 6 89416 42 63399558
Ophthalmoplegia 20.93 9.93 17 89405 1447 63398153
Normal newborn 20.76 9.93 40 89382 8301 63391299
Ventricular hypokinesia 20.73 9.93 29 89393 4615 63394985
Femur fracture 20.72 9.93 17 89405 41739 63357861
Skin infection 20.70 9.93 57 89365 14945 63384655
Meningitis chemical 20.59 9.93 8 89414 156 63399444
Miosis 20.47 9.93 37 89385 7316 63392284
Punctate keratitis 20.30 9.93 12 89410 609 63398991
Bundle branch block left 20.27 9.93 36 89386 7023 63392577
Trigemino-cardiac reflex 20.18 9.93 6 89416 49 63399551
Depressed level of consciousness 20.07 9.93 153 89269 61925 63337675
Device infusion issue 19.78 9.93 19 89403 2019 63397581
Homicide 19.69 9.93 10 89412 375 63399225
Psoriasis 19.68 9.93 60 89362 86897 63312703
Shock 19.52 9.93 75 89347 23388 63376212
Inappropriate schedule of product administration 19.43 9.93 228 89194 103737 63295863
Neuromuscular block prolonged 19.11 9.93 11 89411 531 63399069
Infusion site discolouration 19.11 9.93 13 89409 844 63398756
Abortion spontaneous 19.07 9.93 23 89399 47172 63352428
Substance dependence 18.90 9.93 8 89414 196 63399404
Cholestasis 18.72 9.93 9 89413 29425 63370175
Condition aggravated 18.62 9.93 428 88994 401789 62997811
Infusion site reaction 18.45 9.93 24 89398 3563 63396037
Gastroenteritis viral 18.30 9.93 74 89348 23626 63375974
Eyelid ptosis 18.27 9.93 35 89387 7232 63392368
Red blood cell sedimentation rate increased 18.24 9.93 21 89401 43961 63355639
Neurotoxicity 18.18 9.93 59 89363 16931 63382669
Haemoglobin decreased 18.16 9.93 125 89297 145360 63254240
Infusion site irritation 18.15 9.93 13 89409 917 63398683
Spinal epidural haematoma 18.07 9.93 14 89408 1113 63398487
Decreased appetite 18.05 9.93 247 89175 250805 63148795
Postmortem blood drug level 18.04 9.93 7 89415 136 63399464
Post procedural complication 18.01 9.93 59 89363 17015 63382585
Glossoptosis 17.82 9.93 6 89416 76 63399524
Obesity 17.80 9.93 10 89412 29942 63369658
Nerve block 17.76 9.93 12 89410 770 63398830
Respiratory acidosis 17.70 9.93 33 89389 6682 63392918
Poor quality sleep 17.65 9.93 65 89357 19870 63379730
Pulmonary fibrosis 17.63 9.93 18 89404 39791 63359809
Spinal operation 17.41 9.93 37 89385 8234 63391366
Circulatory collapse 17.34 9.93 69 89353 21869 63377731
Stridor 17.31 9.93 23 89399 3487 63396113
Induced abortion failed 17.28 9.93 8 89414 244 63399356
Paraplegia 17.17 9.93 20 89402 2652 63396948
White blood cell count decreased 17.13 9.93 120 89302 138984 63260616
Hypoxia 16.95 9.93 143 89279 59649 63339951
Blood creatinine increased 16.91 9.93 65 89357 87779 63311821
Eye infarction 16.90 9.93 5 89417 40 63399560
Haematochezia 16.87 9.93 31 89391 53513 63346087
Intentional dose omission 16.86 9.93 36 89386 8039 63391561
Interstitial lung disease 16.83 9.93 39 89383 61869 63337731
Electrocardiogram QT prolonged 16.68 9.93 142 89280 59388 63340212
Accidental overdose 16.60 9.93 71 89351 23238 63376362
Removal of foreign body 16.59 9.93 5 89417 43 63399557
Accidental death 16.55 9.93 17 89405 1959 63397641
Knee arthroplasty 16.53 9.93 32 89390 54174 63345426
Adverse event 16.47 9.93 45 89377 67514 63332086
Serotonin syndrome 16.46 9.93 82 89340 28600 63371000
Device expulsion 16.38 9.93 15 89407 34907 63364693
Vitamin D increased 16.35 9.93 11 89411 701 63398899
Pruritus 16.34 9.93 386 89036 361067 63038533
Nail bed tenderness 16.32 9.93 9 89413 400 63399200
Drug resistance 16.20 9.93 6 89416 22927 63376673
Alcoholic 16.19 9.93 5 89417 47 63399553
Blood ethanol 16.19 9.93 5 89417 47 63399553
Arthritis bacterial 16.09 9.93 31 89391 6432 63393168
Axillary nerve injury 16.06 9.93 4 89418 15 63399585
Procedural complication 15.95 9.93 28 89394 5411 63394189
Pupil fixed 15.95 9.93 16 89406 1793 63397807
Sleep disorder 15.93 9.93 60 89362 81506 63318094
Phrenic nerve paralysis 15.91 9.93 7 89415 189 63399411
Ventricular extrasystoles 15.73 9.93 44 89378 11643 63387957
Congenital umbilical hernia 15.63 9.93 8 89414 305 63399295
Blood pressure decreased 15.61 9.93 150 89272 64872 63334728
Anorgasmia 15.51 9.93 10 89412 593 63399007
Administration site extravasation 15.50 9.93 12 89410 953 63398647
Osteonecrosis of jaw 15.42 9.93 16 89406 35107 63364493
Musculoskeletal stiffness 15.37 9.93 176 89246 184442 63215158
Blood pressure systolic increased 15.33 9.93 27 89395 47370 63352230
Blood ethanol increased 15.30 9.93 6 89416 120 63399480
Injection site abscess 15.23 9.93 13 89409 1185 63398415
Underdose 15.15 9.93 10 89412 27446 63372154
Neonatal toxicity 15.13 9.93 4 89418 20 63399580
Trigeminal palsy 15.13 9.93 4 89418 20 63399580
Incision site rash 15.13 9.93 4 89418 20 63399580
Anaphylactoid shock 15.07 9.93 8 89414 329 63399271
Vasoplegia syndrome 14.93 9.93 15 89407 1684 63397916
Cystitis 14.79 9.93 130 89292 54861 63344739
Brain death 14.79 9.93 21 89401 3389 63396211
Areflexia 14.71 9.93 20 89402 3098 63396502
Gait inability 14.69 9.93 33 89389 52926 63346674
Tooth infection 14.68 9.93 57 89365 17863 63381737
Vascular stenosis 14.58 9.93 8 89414 352 63399248
Viral infection 14.53 9.93 93 89329 35570 63364030
Multiple sclerosis relapse 14.46 9.93 29 89393 48449 63351151
Disease recurrence 14.43 9.93 11 89411 28019 63371581
Gastrointestinal haemorrhage 14.41 9.93 62 89360 81114 63318486
Transferrin decreased 14.39 9.93 7 89415 239 63399361
Anal sphincter atony 14.28 9.93 7 89415 243 63399357
Gastroenteritis 14.25 9.93 10 89412 26580 63373020
Therapeutic response decreased 14.25 9.93 42 89380 61483 63338117
Brain injury 14.25 9.93 31 89391 7012 63392588
Sensory loss 14.23 9.93 39 89383 10199 63389401
Tryptase increased 14.11 9.93 8 89414 375 63399225
Agranulocytosis 14.08 9.93 9 89413 25125 63374475
Opiates positive 14.06 9.93 8 89414 378 63399222
Gait disturbance 13.97 9.93 178 89244 183000 63216600
Emotional distress 13.96 9.93 86 89336 32463 63367137
Tracheal deviation 13.85 9.93 6 89416 156 63399444
Foetal exposure during delivery 13.77 9.93 6 89416 158 63399442
Hepatic encephalopathy 13.76 9.93 41 89381 11241 63388359
Dissociative amnesia 13.75 9.93 4 89418 30 63399570
Pulmonary embolism 13.71 9.93 102 89320 116582 63283018
Autonomic neuropathy 13.57 9.93 12 89410 1147 63398453
Blood pressure fluctuation 13.56 9.93 28 89394 46289 63353311
Gastrointestinal disorder 13.46 9.93 119 89303 131120 63268480
Retinal artery occlusion 13.44 9.93 14 89408 1639 63397961
Asphyxia 13.42 9.93 28 89394 6153 63393447
Product contamination 13.42 9.93 10 89412 750 63398850
Anaphylactoid reaction 13.38 9.93 21 89401 3702 63395898
Liquid product physical issue 13.37 9.93 12 89410 1170 63398430
Weight increased 13.35 9.93 273 89149 260519 63139081
Drug tolerance decreased 13.35 9.93 4 89418 17469 63382131
Hypocalcaemia 13.30 9.93 15 89407 31698 63367902
Nephrolithiasis 13.30 9.93 103 89319 41881 63357719
Spinal stroke 13.21 9.93 4 89418 35 63399565
Airway peak pressure increased 13.19 9.93 7 89415 288 63399312
Immunodeficiency 13.18 9.93 6 89416 20248 63379352
Left ventricle outflow tract obstruction 13.16 9.93 7 89415 289 63399311
Confusional state 13.15 9.93 244 89178 236136 63163464
Hospitalisation 13.09 9.93 180 89242 84901 63314699
Heliotrope rash 13.02 9.93 6 89416 181 63399419
Propionibacterium infection 13.01 9.93 4 89418 37 63399563
Rheumatoid nodule 12.97 9.93 4 89418 17151 63382449
Vascular resistance systemic decreased 12.89 9.93 5 89417 97 63399503
Hemiplegic migraine 12.89 9.93 5 89417 97 63399503
Drug hypersensitivity 12.89 9.93 336 89086 310351 63089249
Hallucination, tactile 12.88 9.93 7 89415 302 63399298
Infusion related reaction 12.87 9.93 256 89166 245265 63154335
Intercepted medication error 12.84 9.93 9 89413 613 63398987
Arthritis 12.84 9.93 103 89319 115818 63283782
Vaginal abscess 12.84 9.93 8 89414 447 63399153
Inappropriate antidiuretic hormone secretion 12.83 9.93 3 89419 15459 63384141
Gastric mucosa erythema 12.73 9.93 7 89415 309 63399291
Pneumocystis jirovecii pneumonia 12.69 9.93 4 89418 16910 63382690
Pupillary reflex impaired 12.62 9.93 15 89407 2032 63397568
Suicidal ideation 12.60 9.93 139 89283 62282 63337318
Myelosuppression 12.59 9.93 9 89413 23694 63375906
Liver function test abnormal 12.58 9.93 31 89391 48150 63351450
Amphetamines positive 12.58 9.93 6 89416 196 63399404
Application site alopecia 12.55 9.93 3 89419 9 63399591
Renal impairment 12.52 9.93 73 89349 88282 63311318
Renal tubular necrosis 12.49 9.93 41 89381 11837 63387763
Harlequin syndrome 12.39 9.93 4 89418 44 63399556
Pancreatitis acute 12.35 9.93 12 89410 27154 63372446
Infusion site warmth 12.35 9.93 14 89408 1804 63397796
Road traffic accident 12.24 9.93 91 89331 36541 63363059
Injection site discharge 12.18 9.93 10 89412 864 63398736
Liver disorder 12.18 9.93 37 89385 53650 63345950
Body dysmorphic disorder 12.18 9.93 7 89415 337 63399263
Therapy cessation 12.15 9.93 79 89343 30378 63369222
Product contamination microbial 12.12 9.93 6 89416 213 63399387
Paralysis 12.09 9.93 36 89386 9864 63389736
Disinhibition 12.09 9.93 10 89412 873 63398727
Orbital infection 12.08 9.93 4 89418 48 63399552
Intraocular pressure fluctuation 12.08 9.93 4 89418 48 63399552
Withdrawal syndrome 12.07 9.93 58 89364 19939 63379661
Implant site swelling 12.00 9.93 8 89414 502 63399098
Eye infection 11.95 9.93 41 89381 12104 63387496
Conjunctival oedema 11.87 9.93 9 89413 693 63398907
Poikiloderma 11.86 9.93 6 89416 223 63399377
Osteoarthritis 11.86 9.93 82 89340 95261 63304339
Implant site bruising 11.83 9.93 7 89415 356 63399244
Incision site swelling 11.81 9.93 6 89416 225 63399375
Product availability issue 11.81 9.93 21 89401 4100 63395500
Infusion site scar 11.80 9.93 8 89414 516 63399084
Infusion site streaking 11.79 9.93 8 89414 517 63399083
Hyperlipasaemia 11.74 9.93 9 89413 704 63398896
Concussion 11.66 9.93 34 89388 9210 63390390
Toxicologic test abnormal 11.65 9.93 9 89413 712 63398888
Platelet count decreased 11.60 9.93 106 89316 116016 63283584
Drug eruption 11.58 9.93 14 89408 28680 63370920
Night sweats 11.54 9.93 33 89389 48781 63350819
Migraine 11.47 9.93 207 89215 103139 63296461
Fear-related avoidance of activities 11.47 9.93 5 89417 132 63399468
Allergy to immunoglobulin therapy 11.45 9.93 4 89418 57 63399543
Product administration error 11.44 9.93 62 89360 22335 63377265
Delirium 11.36 9.93 115 89307 50426 63349174
Arthritis fungal 11.35 9.93 3 89419 15 63399585
Coccygectomy 11.35 9.93 3 89419 15 63399585
Balance disorder 11.31 9.93 71 89351 84351 63315249
Peritonitis 11.29 9.93 5 89417 17149 63382451
Poor venous access 11.28 9.93 46 89376 14739 63384861
Joint stiffness 11.27 9.93 99 89323 41770 63357830
Brachial artery entrapment syndrome 11.26 9.93 4 89418 60 63399540
Sinus disorder 11.25 9.93 66 89356 24487 63375113
Accelerated idioventricular rhythm 11.20 9.93 4 89418 61 63399539
Administration site erythema 11.18 9.93 9 89413 756 63398844
Premenstrual dysphoric disorder 11.14 9.93 4 89418 62 63399538
Inadequate analgesia 11.14 9.93 17 89405 2926 63396674
Quadriparesis 11.11 9.93 14 89408 2015 63397585
Cholestasis of pregnancy 11.10 9.93 11 89411 1214 63398386
Intentional self-injury 11.09 9.93 68 89354 25619 63373981
Paranasal cyst 11.09 9.93 7 89415 400 63399200
Bronchospasm 11.07 9.93 51 89371 17229 63382371
Procedural anxiety 11.07 9.93 9 89413 767 63398833
Spinal cord infarction 11.06 9.93 6 89416 258 63399342
Peripheral venous disease 11.02 9.93 4 89418 15473 63384127
Diplopia 11.01 9.93 64 89358 23664 63375936
Inability to afford medication 10.99 9.93 15 89407 2332 63397268
Cardiac death 10.96 9.93 8 89414 581 63399019
Spinal cord oedema 10.94 9.93 5 89417 148 63399452
Retinal cyst 10.69 9.93 4 89418 70 63399530
Bacterial infection 10.66 9.93 55 89367 19444 63380156
Localised infection 10.64 9.93 76 89346 30134 63369466
Blood calcium decreased 10.57 9.93 13 89409 26438 63373162
Anxiety 10.53 9.93 390 89032 217151 63182449
Metapneumovirus infection 10.51 9.93 10 89412 1050 63398550
Dysarthria 10.48 9.93 99 89323 42612 63356988
Immunisation reaction 10.48 9.93 8 89414 622 63398978
Spinal cord compression 10.46 9.93 20 89402 4128 63395472
Repetitive strain injury 10.41 9.93 5 89417 166 63399434
Bone erosion 10.40 9.93 6 89416 17711 63381889
Foetal heart rate abnormal 10.40 9.93 8 89414 629 63398971
Apnoeic attack 10.40 9.93 6 89416 291 63399309
Hepatocellular injury 10.38 9.93 14 89408 27367 63372233
Obstruction 10.37 9.93 17 89405 3110 63396490
Face oedema 10.36 9.93 56 89366 20156 63379444
Creatinine renal clearance decreased 10.35 9.93 5 89417 16303 63383297
Metabolic acidosis 10.34 9.93 103 89319 44966 63354634
Stevens-Johnson syndrome 10.25 9.93 12 89410 24938 63374662
Hypercalcaemia 10.22 9.93 15 89407 28307 63371293
Genital ulceration 10.20 9.93 8 89414 647 63398953
Wrong product administered 10.19 9.93 25 89397 6116 63393484
Orbital oedema 10.18 9.93 6 89416 303 63399297
Cranial nerve palsies multiple 10.14 9.93 3 89419 24 63399576
Hyperglycaemia 10.12 9.93 28 89394 41839 63357761
Bone marrow failure 10.10 9.93 16 89406 29274 63370326
Lethargy 10.09 9.93 122 89300 55885 63343715
Streptococcal infection 10.07 9.93 24 89398 5763 63393837
Haemorrhagic vasculitis 10.07 9.93 4 89418 83 63399517
Gastrointestinal bacterial overgrowth 10.07 9.93 9 89413 873 63398727
Lack of infusion site rotation 10.03 9.93 3 89419 25 63399575
Electrocardiogram ST segment depression 10.03 9.93 16 89406 2861 63396739
Birth mark 9.98 9.93 5 89417 182 63399418
Amnesia 9.98 9.93 121 89301 55464 63344136

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 3971.46 11.21 2305 56074 96791 34801761
Toxicity to various agents 2728.55 11.21 2414 55965 197948 34700604
Completed suicide 2579.49 11.21 1750 56629 96418 34802134
Cardio-respiratory arrest 582.19 11.21 581 57798 54692 34843860
Intentional overdose 506.36 11.21 484 57895 43190 34855362
Overdose 488.43 11.21 677 57702 90382 34808170
Alcohol abuse 408.09 11.21 185 58194 4505 34894047
Alcohol interaction 386.58 11.21 155 58224 2758 34895794
Intentional product misuse 347.14 11.21 404 57975 45207 34853345
Suspected suicide 270.03 11.21 140 58239 4608 34893944
Suicide attempt 257.54 11.21 322 58057 38794 34859758
Methaemoglobinaemia 248.98 11.21 121 58258 3460 34895092
Alcohol poisoning 239.61 11.21 118 58261 3475 34895077
Drug dependence 221.06 11.21 236 58143 23981 34874571
Substance abuse 220.31 11.21 145 58234 7496 34891056
Cardiac arrest 212.57 11.21 485 57894 95674 34802878
Respiratory depression 191.75 11.21 182 58197 16063 34882489
Coma 186.14 11.21 299 58080 45379 34853173
Respiratory arrest 181.57 11.21 229 58150 27814 34870738
Exposure to toxic agent 149.88 11.21 87 58292 3588 34894964
Asphyxia 137.28 11.21 104 58275 6731 34891821
Diarrhoea 122.89 11.21 296 58083 389616 34508936
Local anaesthetic systemic toxicity 117.24 11.21 36 58343 274 34898278
Alcohol use 116.26 11.21 71 58308 3217 34895335
Anaphylactic reaction 116.20 11.21 200 58179 32101 34866451
Anaesthetic complication 112.91 11.21 49 58330 1071 34897481
Poisoning deliberate 106.38 11.21 95 58284 7749 34890803
Aggression 102.47 11.21 211 58168 38753 34859799
Incorrect route of product administration 97.28 11.21 122 58257 14723 34883829
Death 96.96 11.21 1052 57327 396997 34501555
Tachycardia 95.44 11.21 335 58044 84437 34814115
Toxic anterior segment syndrome 95.04 11.21 44 58335 1125 34897427
Poisoning 92.38 11.21 108 58271 12118 34886434
Anaphylactic shock 91.95 11.21 123 58256 15818 34882734
Mydriasis 85.22 11.21 81 58298 7156 34891396
Blood alcohol increased 82.94 11.21 36 58343 787 34897765
Miosis 81.85 11.21 90 58289 9445 34889107
Anaemia 81.60 11.21 167 58212 233168 34665384
Injury 80.92 11.21 133 58246 20554 34877998
Hypotension 80.11 11.21 638 57741 221011 34677541
Drug use disorder 75.94 11.21 60 58319 4131 34894421
Substance use disorder 75.01 11.21 33 58346 746 34897806
Disease progression 74.55 11.21 44 58335 108033 34790519
Unresponsive to stimuli 74.49 11.21 151 58228 27418 34871134
Fear 65.32 11.21 84 58295 10392 34888160
Decreased appetite 63.44 11.21 113 58266 166279 34732273
Electrocardiogram ST segment elevation 62.39 11.21 59 58320 5179 34893373
Dyspnoea 62.28 11.21 372 58007 376410 34522142
Prescription drug used without a prescription 59.96 11.21 40 58339 2114 34896438
General physical health deterioration 58.59 11.21 77 58302 128192 34770360
Fatigue 58.10 11.21 372 58007 370281 34528271
Depressed level of consciousness 56.80 11.21 179 58200 42662 34855890
Weight decreased 56.76 11.21 132 58247 176169 34722383
Sinusitis 53.98 11.21 172 58207 41230 34857322
Renal injury 53.58 11.21 79 58300 11116 34887436
Intentional product use issue 52.92 11.21 219 58160 59597 34838955
Interstitial lung disease 51.88 11.21 22 58357 65260 34833292
Generalised tonic-clonic seizure 51.39 11.21 111 58268 21063 34877489
Anhedonia 50.75 11.21 63 58316 7522 34891030
Off label use 50.17 11.21 454 57925 419070 34479482
Emotional distress 50.08 11.21 90 58289 14936 34883616
Ventricular tachycardia 48.86 11.21 125 58254 26454 34872098
Agitation 48.32 11.21 207 58172 57192 34841360
Asthenia 47.13 11.21 230 58149 245021 34653531
Drug withdrawal syndrome 47.02 11.21 103 58276 19731 34878821
Electrocardiogram QRS complex prolonged 46.95 11.21 49 58330 4845 34893707
Rash 46.90 11.21 202 58177 222550 34676002
Loss of consciousness 46.65 11.21 266 58113 82401 34816151
Medication error 44.70 11.21 118 58261 25447 34873105
Accidental death 44.15 11.21 35 58344 2421 34896131
White blood cell count decreased 43.87 11.21 57 58322 95388 34803164
Haemoglobin decreased 43.36 11.21 85 58294 120687 34777865
Bradycardia 42.76 11.21 243 58136 75175 34823377
Accidental overdose 42.63 11.21 100 58279 20040 34878512
Alcohol withdrawal syndrome 42.34 11.21 28 58351 1458 34897094
Accident 42.21 11.21 47 58332 5000 34893552
Arthralgia 41.68 11.21 145 58234 169896 34728656
Brain oedema 41.31 11.21 79 58300 13742 34884810
Myocardial infarction 41.11 11.21 88 58291 120997 34777555
Acute kidney injury 40.45 11.21 321 58058 304667 34593885
Behaviour disorder 39.83 11.21 45 58334 4865 34893687
Pulmonary oedema 39.69 11.21 171 58208 47358 34851194
Infusion site pain 39.55 11.21 40 58339 3811 34894741
Cardiac failure congestive 39.02 11.21 49 58330 83221 34815331
Drug screen positive 38.76 11.21 40 58339 3903 34894649
Ventricular fibrillation 38.17 11.21 104 58275 22850 34875702
Suicidal ideation 37.40 11.21 150 58229 40238 34858314
Alcohol intolerance 36.92 11.21 17 58362 429 34898123
Oedema peripheral 36.71 11.21 92 58287 119720 34778832
Metabolic acidosis 35.59 11.21 156 58223 43524 34855028
Pyrexia 35.25 11.21 371 58008 332642 34565910
Anaesthetic complication neurological 34.72 11.21 15 58364 324 34898228
Ex-drug abuser 34.37 11.21 12 58367 142 34898410
Condition aggravated 34.20 11.21 185 58194 192011 34706541
Malignant neoplasm progression 33.32 11.21 60 58319 87986 34810566
Dehydration 33.07 11.21 109 58270 129860 34768692
Neutropenia 33.07 11.21 142 58237 156636 34741916
Platelet count decreased 32.87 11.21 97 58282 119620 34778932
Alcoholism 32.67 11.21 32 58347 2933 34895619
Infusion site extravasation 32.19 11.21 38 58341 4306 34894246
Road traffic accident 32.00 11.21 82 58297 17368 34881184
Rheumatoid arthritis 31.82 11.21 12 58367 38226 34860326
Pain in extremity 30.23 11.21 109 58270 126404 34772148
Drug intolerance 30.11 11.21 33 58346 59537 34839015
Oculocardiac reflex 30.08 11.21 9 58370 62 34898490
Intentional self-injury 29.83 11.21 69 58310 13702 34884850
Leukopenia 29.43 11.21 37 58342 62819 34835733
Cough 29.26 11.21 140 58239 150000 34748552
Infusion site swelling 29.24 11.21 28 58351 2496 34896056
Sinus tachycardia 29.21 11.21 79 58300 17281 34881271
Anal inflammation 28.83 11.21 21 58358 1279 34897273
Myalgia 28.64 11.21 61 58318 84049 34814503
Drug abuser 28.33 11.21 34 58345 3920 34894632
Cardiac failure 27.99 11.21 70 58309 91178 34807374
Haematochezia 27.98 11.21 22 58357 46512 34852040
Cytomegalovirus infection 27.83 11.21 5 58374 26130 34872422
Abdominal pain 27.73 11.21 160 58219 163458 34735094
Respiratory acidosis 27.65 11.21 38 58341 5012 34893540
Thrombocytopenia 27.44 11.21 151 58228 156096 34742456
Homicide 27.33 11.21 18 58361 931 34897621
Malaise 27.24 11.21 190 58189 185635 34712917
Opiates positive 27.05 11.21 15 58364 566 34897986
Pancytopenia 26.91 11.21 76 58303 95081 34803471
Loss of personal independence in daily activities 26.64 11.21 11 58368 33168 34865384
Agranulocytosis 26.60 11.21 4 58375 23817 34874735
Hypoxia 26.43 11.21 170 58209 54925 34843627
Ear infection 26.40 11.21 55 58324 10176 34888376
Infusion site bruising 26.05 11.21 16 58363 732 34897820
Nausea 25.47 11.21 407 57972 339501 34559051
Psoriasis 25.09 11.21 17 58362 38795 34859757
Shock 24.99 11.21 93 58286 24086 34874466
Hyperthermia malignant 24.93 11.21 24 58355 2153 34896399
Drug reaction with eosinophilia and systemic symptoms 24.85 11.21 12 58367 33000 34865552
Therapeutic product effect incomplete 24.45 11.21 29 58350 50512 34848040
Conjunctival scar 24.15 11.21 9 58370 130 34898422
Dyspnoea exertional 24.13 11.21 22 58357 43257 34855295
Infusion site erythema 24.06 11.21 24 58355 2249 34896303
Foetal alcohol syndrome 23.78 11.21 9 58370 136 34898416
Therapy interrupted 23.72 11.21 63 58316 13634 34884918
Pneumonia 23.70 11.21 445 57934 362182 34536370
Myocardial fibrosis 23.56 11.21 18 58361 1179 34897373
Prostate cancer 23.51 11.21 19 58360 39630 34858922
Spinal cord infarction 23.38 11.21 11 58368 292 34898260
Abdominal discomfort 23.34 11.21 40 58339 59795 34838757
Amnesia 23.27 11.21 97 58282 26466 34872086
Neuropathy peripheral 23.18 11.21 67 58312 83196 34815356
Weight increased 22.99 11.21 79 58300 92954 34805598
Impaired driving ability 22.85 11.21 25 58354 2608 34895944
Angina pectoris 22.71 11.21 12 58367 31351 34867201
Embolia cutis medicamentosa 22.61 11.21 10 58369 229 34898323
Blood pressure fluctuation 22.61 11.21 7 58372 25242 34873310
Blood creatinine increased 22.56 11.21 82 58297 94894 34803658
Somnolence 22.51 11.21 284 58095 110832 34787720
Tubulointerstitial nephritis 22.43 11.21 4 58375 21020 34877532
Withdrawal syndrome 22.29 11.21 58 58321 12397 34886155
Sensorimotor disorder 22.20 11.21 12 58367 430 34898122
Melaena 22.20 11.21 16 58363 35364 34863188
Chemical burn 22.14 11.21 10 58369 241 34898311
Brain stem syndrome 22.04 11.21 13 58366 552 34898000
Coronary artery disease 22.02 11.21 29 58350 48276 34850276
Unevaluable event 21.85 11.21 110 58269 32480 34866072
Corneal oedema 21.64 11.21 18 58361 1333 34897219
SARS-CoV-2 test negative 21.54 11.21 16 58363 1004 34897548
Diabetes mellitus 21.52 11.21 28 58351 46845 34851707
Blood pressure systolic increased 21.21 11.21 6 58373 22946 34875606
Blood ethanol 21.19 11.21 8 58371 120 34898432
Apnoea 21.04 11.21 39 58340 6625 34891927
Circulatory collapse 20.98 11.21 80 58299 20958 34877594
Dysarthria 20.98 11.21 114 58265 34668 34863884
Postmortem blood drug level 20.94 11.21 9 58370 192 34898360
Pupil fixed 20.90 11.21 20 58359 1781 34896771
Haematuria 20.90 11.21 32 58347 50034 34848518
Pruritus 20.87 11.21 145 58234 141836 34756716
Removal of foreign body 20.49 11.21 6 58373 38 34898514
Drug resistance 20.17 11.21 9 58370 25918 34872634
Deep vein thrombosis 20.05 11.21 50 58329 65198 34833354
Seizure 19.97 11.21 265 58114 104592 34793960
Aqueous fibrin 19.73 11.21 6 58373 44 34898508
Somnambulism 19.73 11.21 25 58354 3047 34895505
Acute pulmonary oedema 19.56 11.21 40 58339 7303 34891249
Tryptase increased 19.51 11.21 9 58370 228 34898324
Transient ischaemic attack 19.36 11.21 11 58368 27602 34870950
Intracranial hypotension 19.26 11.21 9 58370 235 34898317
Respiratory tract infection bacterial 19.20 11.21 19 58360 1763 34896789
Lagophthalmos 19.18 11.21 7 58372 95 34898457
Disease recurrence 19.17 11.21 6 58373 21484 34877068
Septic shock 19.13 11.21 59 58320 71775 34826777
Insurance issue 18.82 11.21 20 58359 2019 34896533
Endophthalmitis 18.61 11.21 26 58353 3482 34895070
Pneumocystis jirovecii pneumonia 18.50 11.21 5 58374 19705 34878847
Musculoskeletal stiffness 18.39 11.21 31 58348 46649 34851903
Dextrocardia 17.96 11.21 7 58372 115 34898437
Hepatic function abnormal 17.90 11.21 29 58350 44334 34854218
Physical assault 17.81 11.21 15 58364 1130 34897422
Bezoar 17.67 11.21 15 58364 1142 34897410
Reperfusion arrhythmia 17.58 11.21 6 58373 66 34898486
Spinal operation 17.41 11.21 23 58356 2921 34895631
Bone marrow failure 17.37 11.21 14 58365 29239 34869313
Stress 17.32 11.21 98 58281 30249 34868303
Renal impairment 17.32 11.21 90 58289 94423 34804129
Respiratory paralysis 17.19 11.21 6 58373 71 34898481
Hepatic fibrosis 17.18 11.21 29 58350 4578 34893974
Restlessness 17.08 11.21 86 58293 25396 34873156
Liver disorder 16.98 11.21 18 58361 32979 34865573
Constipation 16.81 11.21 147 58232 136835 34761717
Dyspepsia 16.80 11.21 22 58357 36710 34861842
Anxiety 16.80 11.21 246 58133 99182 34799370
Catecholamine crisis 16.77 11.21 5 58374 34 34898518
Pulmonary fibrosis 16.65 11.21 5 58374 18391 34880161
Product prescribing error 16.27 11.21 9 58370 22918 34875634
Bronchospasm 16.24 11.21 47 58332 10684 34887868
Asthma 16.19 11.21 29 58350 42627 34855925
Diabetic ketoacidosis 16.14 11.21 5 58374 18027 34880525
Anal sphincter atony 15.83 11.21 6 58373 91 34898461
Substance-induced mood disorder 15.83 11.21 6 58373 91 34898461
Drug level increased 15.82 11.21 76 58303 22020 34876532
Accidental poisoning 15.81 11.21 12 58367 778 34897774
Respiratory tract infection 15.74 11.21 70 58309 19642 34878910
Injection site ulcer 15.69 11.21 8 58371 254 34898298
Vitreous disorder 15.60 11.21 6 58373 95 34898457
Dizziness 15.55 11.21 264 58115 218257 34680295
Neuromuscular blockade 15.52 11.21 8 58371 260 34898292
Respiratory tract infection viral 15.40 11.21 20 58359 2497 34896055
Muscular weakness 15.36 11.21 66 58313 72831 34825721
Wrong product administered 15.34 11.21 30 58349 5304 34893248
Visceral oedema 15.32 11.21 6 58373 100 34898452
Product adhesion issue 15.31 11.21 16 58363 1584 34896968
Infusion site haemorrhage 15.30 11.21 13 58366 991 34897561
Electrocardiogram T wave amplitude increased 15.26 11.21 5 58374 48 34898504
Trigemino-cardiac reflex 14.87 11.21 7 58372 186 34898366
Gastrointestinal disorder 14.85 11.21 21 58358 33927 34864625
Red blood cell count decreased 14.82 11.21 16 58363 29074 34869478
Toxicologic test abnormal 14.70 11.21 10 58369 546 34898006
Jaundice 14.68 11.21 19 58360 31863 34866689
Tracheitis 14.63 11.21 11 58368 703 34897849
Feeling drunk 14.54 11.21 17 58362 1906 34896646
Sopor 14.53 11.21 49 58330 12087 34886465
Myelosuppression 14.50 11.21 7 58372 19258 34879294
Phaeochromocytoma crisis 14.41 11.21 5 58374 58 34898494
Pulseless electrical activity 14.39 11.21 35 58344 7176 34891376
Suicidal behaviour 14.38 11.21 15 58364 1482 34897070
Hypercalcaemia 14.38 11.21 4 58375 15464 34883088
Neutrophil count decreased 14.30 11.21 41 58338 51063 34847489
Gastrointestinal haemorrhage 14.18 11.21 88 58291 88389 34810163
Alopecia 14.03 11.21 12 58367 24343 34874209
Joint swelling 14.02 11.21 52 58327 59838 34838714
Neoplasm progression 14.02 11.21 11 58368 23289 34875263
Gun shot wound 14.00 11.21 13 58366 1115 34897437
Amphetamines positive 13.97 11.21 7 58372 214 34898338
Myoclonus 13.87 11.21 55 58324 14670 34883882
Mobility decreased 13.82 11.21 18 58361 30110 34868442
Psychiatric disorder prophylaxis 13.69 11.21 5 58374 68 34898484
Hypoxic-ischaemic encephalopathy 13.66 11.21 26 58353 4506 34894046
Behavioural addiction 13.63 11.21 5 58374 69 34898483
Sepsis 13.60 11.21 196 58183 166365 34732187
Pulse absent 13.59 11.21 30 58349 5773 34892779
Delirium tremens 13.57 11.21 10 58369 620 34897932
Product preparation error 13.54 11.21 18 58361 2299 34896253
Delayed recovery from anaesthesia 13.52 11.21 11 58368 790 34897762
Hyperkalaemia 13.32 11.21 65 58314 69324 34829228
International normalised ratio increased 13.22 11.21 38 58341 47289 34851263
Brachial plexus injury 13.19 11.21 5 58374 76 34898476
Retinal artery occlusion 13.16 11.21 16 58363 1869 34896683
Arthritis 13.11 11.21 20 58359 31326 34867226
Accidental exposure to product 13.03 11.21 49 58330 12753 34885799
Ventricular tachyarrhythmia 13.03 11.21 8 58371 366 34898186
Incorrect drug administration rate 12.77 11.21 15 58364 1690 34896862
Eosinophilia 12.73 11.21 15 58364 26207 34872345
Drug diversion 12.62 11.21 11 58368 868 34897684
Myokymia 12.57 11.21 5 58374 87 34898465
Pulmonary embolism 12.52 11.21 93 58286 89653 34808899
Product administration error 12.27 11.21 57 58322 16287 34882265
Proteinuria 12.27 11.21 8 58371 18634 34879918
Peritonitis 12.24 11.21 6 58373 16359 34882193
Haemoptysis 12.23 11.21 25 58354 34981 34863571
Cluster headache 12.23 11.21 9 58370 557 34897995
Bradypnoea 12.17 11.21 19 58360 2810 34895742
Retinal vasculitis 12.07 11.21 8 58371 418 34898134
Procedural hypotension 12.03 11.21 11 58368 925 34897627
Administration related reaction 12.02 11.21 5 58374 98 34898454
Underdose 12.02 11.21 4 58375 13776 34884776
Dysgeusia 11.98 11.21 16 58363 26481 34872071
Cauda equina syndrome 11.95 11.21 9 58370 577 34897975
Corneal opacity 11.95 11.21 9 58370 577 34897975
Postmortem blood drug level abnormal 11.94 11.21 7 58372 294 34898258
Cardiotoxicity 11.90 11.21 28 58351 5620 34892932
Haemodynamic instability 11.89 11.21 39 58340 9484 34889068
Seizure like phenomena 11.87 11.21 10 58369 754 34897798
Administration site pain 11.83 11.21 7 58372 299 34898253
Acute myocardial infarction 11.71 11.21 48 58331 53671 34844881
Alcoholic liver disease 11.65 11.21 9 58370 599 34897953
Injection site extravasation 11.61 11.21 19 58360 2923 34895629
Chronic kidney disease 11.58 11.21 33 58346 41177 34857375
Febrile neutropenia 11.54 11.21 160 58219 136689 34761863
Colitis 11.53 11.21 29 58350 37721 34860831
Phlebitis superficial 11.48 11.21 7 58372 316 34898236
Arthropathy 11.42 11.21 17 58362 26890 34871662
Blood glucose increased 11.41 11.21 65 58314 66653 34831899
Benzodiazepine drug level therapeutic 11.41 11.21 4 58375 48 34898504
Alcoholic pancreatitis 11.39 11.21 6 58373 204 34898348
Electrocardiogram repolarisation abnormality 11.37 11.21 11 58368 993 34897559
Vitreous floaters 11.34 11.21 21 58358 3564 34894988
Drug interaction 11.29 11.21 473 57906 225473 34673079
Patient uncooperative 11.28 11.21 8 58371 467 34898085

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5901.05 9.83 3968 115099 241799 79383522
Drug abuse 4976.63 9.83 3063 116004 159628 79465693
Toxicity to various agents 4850.20 9.83 4402 114665 417138 79208183
Cardio-respiratory arrest 1343.34 9.83 1187 117880 107323 79517998
Intentional overdose 886.90 9.83 935 118132 105025 79520296
Overdose 790.78 9.83 1162 117905 183044 79442277
Cardiac arrest 618.13 9.83 1000 118067 171096 79454225
Alcohol interaction 610.01 9.83 241 118826 4633 79620688
Local anaesthetic systemic toxicity 512.54 9.83 145 118922 909 79624412
Suspected suicide 489.98 9.83 262 118805 10314 79615007
Intentional product misuse 466.33 9.83 640 118427 94525 79530796
Alcohol abuse 385.28 9.83 179 118888 5184 79620137
Death 375.28 9.83 1755 117312 564759 79060562
Respiratory arrest 374.95 9.83 446 118621 57104 79568217
Methaemoglobinaemia 370.02 9.83 176 118891 5381 79619940
Alcohol poisoning 355.97 9.83 164 118903 4657 79620664
Suicide attempt 329.31 9.83 505 118562 82427 79542894
Toxic anterior segment syndrome 308.95 9.83 126 118941 2638 79622683
Exposure to toxic agent 297.74 9.83 180 118887 8978 79616343
Coma 232.83 9.83 484 118583 100165 79525156
Drug dependence 220.69 9.83 288 118779 40481 79584840
Anaphylactic reaction 220.39 9.83 425 118642 83318 79542003
Substance abuse 215.55 9.83 155 118912 10371 79614950
Alcohol use 210.70 9.83 115 118952 4716 79620605
Anaesthetic complication 210.27 9.83 97 118970 2762 79622559
Diarrhoea 183.47 9.83 687 118380 879802 78745519
Respiratory depression 182.97 9.83 216 118851 27414 79597907
Anaphylactic shock 177.53 9.83 243 118824 35753 79589568
Synovitis 169.62 9.83 15 119052 150719 79474602
General physical health deterioration 148.60 9.83 116 118951 275122 79350199
Poisoning deliberate 148.16 9.83 161 118906 18667 79606654
Mydriasis 147.88 9.83 156 118911 17487 79607834
Arthralgia 146.83 9.83 406 118661 571397 79053924
Incorrect route of product administration 143.22 9.83 216 118851 34713 79590608
Hypotension 135.54 9.83 1121 117946 439196 79186125
Drug intolerance 134.30 9.83 118 118949 264001 79361320
Joint swelling 133.92 9.83 140 118927 288506 79336815
Generalised tonic-clonic seizure 125.60 9.83 231 118836 43679 79581642
Tachycardia 125.39 9.83 562 118505 177206 79448115
Unresponsive to stimuli 123.97 9.83 264 118803 55524 79569797
Asphyxia 122.84 9.83 117 118950 11603 79613718
Blood alcohol increased 121.12 9.83 52 119015 1243 79624078
Hand deformity 120.63 9.83 9 119058 103910 79521411
Abdominal discomfort 120.40 9.83 118 118949 250609 79374712
Poisoning 114.77 9.83 164 118903 25108 79600213
Pemphigus 114.53 9.83 9 119058 99573 79525748
Kounis syndrome 113.62 9.83 74 118993 4208 79621113
Anti-cyclic citrullinated peptide antibody positive 110.04 9.83 3 119064 83140 79542181
Agitation 108.70 9.83 362 118705 99353 79525968
Pericarditis 108.00 9.83 14 119053 104222 79521099
Maternal exposure during delivery 106.33 9.83 48 119019 1298 79624023
Miosis 103.81 9.83 123 118944 15666 79609655
Aggression 102.84 9.83 232 118835 50726 79574595
Systemic lupus erythematosus 102.63 9.83 27 119040 121122 79504199
Glossodynia 102.11 9.83 16 119051 103321 79522000
Rash 101.70 9.83 481 118586 577877 79047444
Therapy interrupted 101.37 9.83 174 118893 31167 79594154
Alopecia 99.84 9.83 119 118948 231236 79394085
Drug use disorder 99.60 9.83 91 118976 8560 79616761
Loss of consciousness 99.57 9.83 505 118562 167438 79457883
Hepatic enzyme increased 98.46 9.83 77 118990 182533 79442788
Substance use disorder 95.49 9.83 40 119027 898 79624423
Seizure 95.11 9.83 543 118524 188291 79437030
Fear 91.61 9.83 137 118930 21849 79603472
Fatigue 91.48 9.83 918 118149 928809 78696512
Electrocardiogram ST segment elevation 90.24 9.83 85 118982 8312 79617009
Bradycardia 89.94 9.83 421 118646 135136 79490185
Electrocardiogram QRS complex prolonged 89.39 9.83 95 118972 10738 79614583
Disease progression 85.93 9.83 89 118978 184273 79441048
Ventricular tachycardia 85.82 9.83 192 118875 41743 79583578
Asthenia 85.60 9.83 433 118634 511256 79114065
Renal injury 84.55 9.83 115 118952 16812 79608509
Pulseless electrical activity 82.86 9.83 104 118963 14056 79611265
Off label use 82.22 9.83 913 118154 906302 78719019
Anaesthetic complication neurological 81.12 9.83 32 119035 612 79624709
Helicobacter infection 81.00 9.83 6 119061 69698 79555623
Dyspnoea 79.83 9.83 857 118210 856168 78769153
Duodenal ulcer perforation 78.98 9.83 5 119062 66206 79559115
Therapeutic product effect decreased 78.77 9.83 77 118990 163786 79461535
Rheumatoid arthritis 78.00 9.83 119 118948 208351 79416970
Contraindicated product administered 75.75 9.83 74 118993 157464 79467857
Pulmonary oedema 75.43 9.83 296 118771 87958 79537363
Rheumatoid factor positive 72.95 9.83 4 119063 59835 79565486
Arthropathy 72.31 9.83 95 118972 177016 79448305
Sinus tachycardia 72.21 9.83 166 118901 36742 79588579
Anaemia 71.89 9.83 381 118686 444634 79180687
Mobility decreased 71.76 9.83 47 119020 122128 79503193
Corneal oedema 71.29 9.83 46 119021 2574 79622747
Ventricular fibrillation 70.82 9.83 151 118916 31775 79593546
Anhedonia 69.59 9.83 98 118969 14800 79610521
Depressed level of consciousness 67.66 9.83 305 118762 96347 79528974
Decreased appetite 64.12 9.83 278 118789 342140 79283181
Postmortem blood drug level abnormal 63.61 9.83 27 119040 627 79624694
Infusion site pruritus 63.05 9.83 51 119016 4067 79621254
Acute kidney injury 62.76 9.83 486 118581 518918 79106403
Unevaluable event 61.63 9.83 203 118864 55382 79569939
Accidental death 59.15 9.83 50 119017 4241 79621080
Wound 58.88 9.83 52 119015 116127 79509194
Infusion site pain 58.58 9.83 88 118979 14088 79611233
Folliculitis 58.43 9.83 7 119060 55373 79569948
Infusion site swelling 58.24 9.83 65 119002 7761 79617560
Swelling 57.61 9.83 151 118916 216560 79408761
Neutropenia 57.32 9.83 228 118839 287482 79337839
Alcoholism 56.78 9.83 46 119021 3677 79621644
Accidental overdose 56.52 9.83 158 118909 39423 79585898
Procedural hypotension 56.24 9.83 36 119031 1987 79623334
Infusion site erythema 56.18 9.83 70 118997 9390 79615931
Lagophthalmos 55.76 9.83 22 119045 421 79624900
Extradural abscess 55.11 9.83 32 119035 1480 79623841
Condition aggravated 54.56 9.83 482 118585 500642 79124679
Apnoea 53.21 9.83 76 118991 11628 79613693
Somnolence 53.06 9.83 568 118499 238413 79386908
Weight decreased 53.02 9.83 312 118755 354886 79270435
Interstitial lung disease 52.85 9.83 54 119013 112546 79512775
Infusion site extravasation 52.51 9.83 70 118997 10038 79615283
Insurance issue 52.20 9.83 53 119014 5680 79619641
Product adhesion issue 51.24 9.83 38 119029 2666 79622655
Pulse absent 51.01 9.83 69 118998 10034 79615287
Emotional distress 50.76 9.83 153 118914 39816 79585505
Shock 50.04 9.83 161 118906 43387 79581934
Psoriatic arthropathy 50.03 9.83 27 119040 77972 79547349
Incorrect drug administration rate 49.60 9.83 44 119023 3982 79621339
Drug reaction with eosinophilia and systemic symptoms 49.53 9.83 17 119050 64227 79561094
Abdominal pain upper 49.40 9.83 170 118897 223649 79401672
Prescription drug used without a prescription 49.05 9.83 44 119023 4041 79621280
Endophthalmitis 48.89 9.83 54 119013 6374 79618947
Impaired healing 48.45 9.83 36 119031 87619 79537702
Infusion site bruising 48.27 9.83 38 119029 2914 79622407
Embolia cutis medicamentosa 48.09 9.83 22 119045 614 79624707
Behaviour disorder 47.96 9.83 53 119014 6260 79619061
Hypoxia 47.49 9.83 290 118777 102953 79522368
Metabolic acidosis 47.35 9.83 246 118821 82283 79543038
Muscle injury 46.89 9.83 8 119059 48553 79576768
Infusion related reaction 46.77 9.83 181 118886 230056 79395265
Body tinea 46.66 9.83 31 119036 1823 79623498
Infusion site haemorrhage 46.52 9.83 41 119026 3679 79621642
Musculoskeletal stiffness 46.46 9.83 122 118945 174886 79450435
Cardiac failure congestive 46.18 9.83 89 118978 142313 79483008
Stress cardiomyopathy 45.69 9.83 69 118998 11097 79614224
Respiratory acidosis 45.53 9.83 69 118998 11131 79614190
Peripheral swelling 45.07 9.83 228 118839 269389 79355932
Abdominal pain 44.93 9.83 369 118698 389200 79236121
Extradural haematoma 44.84 9.83 36 119031 2840 79622481
Hypopyon 43.84 9.83 25 119042 1117 79624204
Pancytopenia 43.65 9.83 116 118951 165629 79459692
Chemical submission 43.35 9.83 17 119050 320 79625001
Nausea 43.28 9.83 1094 117973 956102 78669219
Pyrexia 42.97 9.83 734 118333 677975 78947346
Drug level increased 42.34 9.83 143 118924 39508 79585813
White blood cell count decreased 42.23 9.83 142 118925 188146 79437175
Sinusitis 42.15 9.83 462 118605 195039 79430282
Loss of personal independence in daily activities 41.87 9.83 55 119012 102525 79522796
Thrombocytopenia 41.72 9.83 229 118838 265030 79360291
Cough 41.57 9.83 349 118718 366440 79258881
Malignant neoplasm progression 41.53 9.83 88 118979 135902 79489419
Opiates positive 41.31 9.83 23 119044 981 79624340
Haematochezia 41.16 9.83 42 119025 87603 79537718
Aqueous fibrin 41.09 9.83 13 119054 125 79625196
Injury 41.06 9.83 226 118841 77270 79548051
Lower respiratory tract infection 40.83 9.83 82 118985 129138 79496183
Homicide 40.33 9.83 24 119043 1162 79624159
Drug hypersensitivity 40.24 9.83 271 118796 298645 79326676
Nystagmus 40.24 9.83 61 119006 9843 79615478
Retinal vasculitis 39.92 9.83 25 119042 1328 79623993
Pruritus 39.72 9.83 387 118680 394261 79231060
Postmortem blood drug level 39.36 9.83 16 119051 332 79624989
Cauda equina syndrome 39.08 9.83 25 119042 1378 79623943
Malaise 38.83 9.83 507 118560 489362 79135959
Haemoglobin decreased 38.75 9.83 185 118882 221934 79403387
Leukopenia 38.49 9.83 72 118995 116441 79508880
COVID-19 38.42 9.83 382 118685 157292 79468029
Agranulocytosis 38.19 9.83 10 119057 45020 79580301
Weight increased 38.08 9.83 250 118817 277136 79348185
Vitritis 38.07 9.83 27 119040 1767 79623554
Drug ineffective 37.92 9.83 1279 117788 1079634 78545687
Blood pressure fluctuation 37.86 9.83 27 119040 67118 79558203
Drug screen positive 37.84 9.83 46 119021 6017 79619304
Alcohol withdrawal syndrome 37.52 9.83 28 119039 1983 79623338
Blood ethanol 37.35 9.83 13 119054 172 79625149
C-reactive protein increased 37.34 9.83 86 118981 128941 79496380
Brain oedema 37.20 9.83 102 118965 25161 79600160
Anterior chamber cell 37.04 9.83 21 119046 928 79624393
Circulatory collapse 36.88 9.83 132 118935 37536 79587785
Pain in extremity 36.88 9.83 357 118710 364181 79261140
Type 2 diabetes mellitus 36.30 9.83 20 119047 57102 79568219
Myelosuppression 36.04 9.83 8 119059 40288 79585033
Seasonal allergy 35.70 9.83 77 118990 16329 79608992
Mental status changes 35.29 9.83 195 118872 66764 79558557
Drug abuser 34.92 9.83 44 119023 5969 79619352
Fear of eating 34.63 9.83 16 119051 457 79624864
Drug interaction 34.42 9.83 837 118230 414346 79210975
Oedema peripheral 34.31 9.83 228 118839 252060 79373261
Removal of foreign body 34.15 9.83 10 119057 72 79625249
Infusion site mass 33.86 9.83 24 119043 1569 79623752
Intentional self-injury 33.81 9.83 116 118951 32303 79593018
Nasopharyngitis 33.75 9.83 231 118836 253650 79371671
Spinal cord infarction 33.33 9.83 17 119050 606 79624715
Hypersensitivity 33.20 9.83 242 118825 261997 79363324
Surgery 33.09 9.83 116 118951 32650 79592671
Victim of sexual abuse 32.84 9.83 16 119051 516 79624805
Trigemino-cardiac reflex 32.61 9.83 13 119054 256 79625065
Accident 32.54 9.83 52 119015 8779 79616542
Septic shock 32.29 9.83 86 118981 122715 79502606
Blister 31.92 9.83 83 118984 119393 79505928
Gastrointestinal disorder 31.81 9.83 86 118981 122119 79503202
Pulmonary fibrosis 31.78 9.83 13 119054 44099 79581222
Blood pressure systolic increased 31.57 9.83 32 119035 66954 79558367
Liver disorder 31.47 9.83 37 119030 72380 79552941
Drug resistance 31.14 9.83 12 119055 42201 79583120
Oculocardiac reflex 31.08 9.83 9 119058 62 79625259
Psoriasis 30.81 9.83 54 119013 89533 79535788
Withdrawal syndrome 30.59 9.83 99 118968 26755 79598566
Ophthalmoplegia 30.38 9.83 29 119038 2883 79622438
Drug withdrawal syndrome 30.10 9.83 117 118950 34601 79590720
Purtscher retinopathy 29.92 9.83 10 119057 116 79625205
Cardiogenic shock 29.87 9.83 133 118934 41781 79583540
Orthostatic hypotension 29.85 9.83 24 119043 56140 79569181
Tryptase increased 29.74 9.83 16 119051 637 79624684
Anal sphincter atony 29.74 9.83 13 119054 325 79624996
Amphetamines positive 29.59 9.83 13 119054 329 79624992
Retinal artery occlusion 29.17 9.83 30 119037 3264 79622057
Anal inflammation 29.14 9.83 21 119046 1409 79623912
Rheumatic fever 29.14 9.83 4 119063 28521 79596800
Arthritis 29.04 9.83 82 118985 114798 79510523
Myocardial infarction 28.91 9.83 159 118908 183970 79441351
Underdose 28.81 9.83 7 119060 33144 79592177
Hyponatraemia 28.80 9.83 152 118915 177696 79447625
Disease recurrence 28.68 9.83 15 119052 44094 79581227
Infusion site urticaria 28.63 9.83 19 119048 1115 79624206
Hyperthermia malignant 28.46 9.83 28 119039 2889 79622432
Corneal epithelium defect 28.30 9.83 16 119051 703 79624618
Prescribed underdose 28.19 9.83 5 119062 29509 79595812
Conjunctival scar 28.10 9.83 11 119056 206 79625115
Systemic toxicity 28.08 9.83 10 119057 142 79625179
Platelet count decreased 27.95 9.83 173 118894 194491 79430830
Cyanosis 27.93 9.83 92 118975 25090 79600231
Infection susceptibility increased 27.85 9.83 31 119036 3690 79621631
Myocardial fibrosis 27.85 9.83 22 119045 1696 79623625
Bronchospasm 27.74 9.83 91 118976 24768 79600553
Stomatitis 27.52 9.83 119 118948 146638 79478683
Gastrointestinal toxicity 27.51 9.83 46 119021 8063 79617258
Blood cholesterol increased 27.42 9.83 52 119015 83668 79541653
Therapy cessation 27.38 9.83 120 118947 37442 79587879
Product administration error 27.35 9.83 107 118960 31739 79593582
Ill-defined disorder 27.21 9.83 35 119032 65840 79559481
Pupil fixed 27.19 9.83 30 119037 3536 79621785
Blood creatinine increased 27.12 9.83 129 118938 154928 79470393
Osteoarthritis 27.07 9.83 56 119011 87253 79538068
Suicidal ideation 27.03 9.83 201 118866 76139 79549182
Cytomegalovirus infection 27.00 9.83 15 119052 42629 79582692
Adverse event 26.99 9.83 30 119037 60184 79565137
Illness 26.92 9.83 139 118928 46372 79578949
Ear infection 26.64 9.83 112 118955 34320 79591001
Discomfort 26.63 9.83 97 118970 125520 79499801
Red blood cell sedimentation rate increased 26.53 9.83 18 119049 45924 79579397
Serotonin syndrome 26.37 9.83 135 118932 44892 79580429
Gastrointestinal haemorrhage 26.36 9.83 122 118945 147597 79477724
Medication error 26.19 9.83 184 118883 68458 79556863
Pneumocephalus 26.00 9.83 12 119055 342 79624979
Hyperkalaemia 25.83 9.83 86 118981 114312 79511009
Somnambulism 25.78 9.83 37 119030 5684 79619637
Bone marrow failure 25.74 9.83 23 119044 51084 79574237
Dysarthria 25.64 9.83 181 118886 67441 79557880
Status epilepticus 25.59 9.83 89 118978 24952 79600369
Chemical burn 25.54 9.83 14 119053 579 79624742
Melaena 25.52 9.83 32 119035 60858 79564463
Product prescribing error 25.29 9.83 18 119049 44795 79580526
Type I hypersensitivity 25.25 9.83 32 119035 4366 79620955
Wrong product administered 25.25 9.83 47 119020 8965 79616356
Road traffic accident 24.93 9.83 130 118937 43534 79581787
Intentional product use issue 24.76 9.83 341 118726 151771 79473550
Pneumocystis jirovecii pneumonia 24.38 9.83 9 119058 32499 79592822
Obesity 24.27 9.83 11 119056 35114 79590207
Dehydration 24.26 9.83 245 118822 247942 79377379
Respiratory tract infection bacterial 24.21 9.83 22 119045 2055 79623266
Meningitis chemical 24.14 9.83 10 119057 218 79625103
Therapeutic product effect incomplete 24.10 9.83 119 118948 141526 79483795
Platelet aggregation inhibition 23.90 9.83 9 119058 151 79625170
Irritable bowel syndrome 23.77 9.83 35 119032 62206 79563115
Diabetes mellitus 23.70 9.83 51 119016 78339 79546982
Victim of chemical submission 23.64 9.83 13 119054 541 79624780
Blood ethanol increased 23.50 9.83 14 119053 679 79624642
Inhibitory drug interaction 23.38 9.83 31 119036 4422 79620899
Toxicologic test abnormal 23.31 9.83 18 119049 1342 79623979
Treatment failure 23.20 9.83 154 118913 170332 79454989
Electrocardiogram QT prolonged 22.99 9.83 221 118846 90165 79535156
Congestive hepatopathy 22.87 9.83 31 119036 4516 79620805
COVID-19 immunisation 22.86 9.83 18 119049 1381 79623940
Sensorimotor disorder 22.62 9.83 15 119052 879 79624442
Product preparation error 22.58 9.83 35 119032 5758 79619563
Alcohol intolerance 22.42 9.83 12 119055 473 79624848
Nerve root injury 22.35 9.83 6 119061 30 79625291
Neurotoxicity 22.28 9.83 102 118965 32416 79592905
Spinal anaesthesia 22.25 9.83 7 119060 66 79625255
Delayed recovery from anaesthesia 22.05 9.83 19 119048 1654 79623667
Bursitis infective 21.79 9.83 17 119050 1287 79624034
Parophthalmia 21.72 9.83 11 119056 386 79624935
Punctate keratitis 21.29 9.83 15 119052 971 79624350
Respiratory tract infection 21.27 9.83 135 118932 48554 79576767
Normal newborn 21.23 9.83 38 119029 7034 79618287
Cholestasis 21.20 9.83 28 119039 52081 79573240
Atonic urinary bladder 21.04 9.83 7 119060 80 79625241
Hypercalcaemia 20.95 9.83 16 119051 38414 79586907
Hepatic function abnormal 20.93 9.83 49 119018 73058 79552263
Anxiety 20.86 9.83 502 118565 248010 79377311
Gait inability 20.72 9.83 35 119032 58882 79566439
Neuromuscular block prolonged 20.70 9.83 15 119052 1015 79624306
Glossoptosis 20.70 9.83 9 119058 222 79625099
Cardiotoxicity 20.66 9.83 52 119015 12187 79613134
Peripheral nerve injury 20.58 9.83 13 119054 701 79624620
Constipation 20.57 9.83 298 118769 282752 79342569
Dizziness 20.50 9.83 614 118453 525827 79099494
Upper airway obstruction 20.43 9.83 17 119050 1411 79623910
Paraplegia 20.35 9.83 31 119036 5022 79620299
Renal impairment 20.25 9.83 145 118922 157638 79467683
Diabetic ketoacidosis 20.20 9.83 13 119054 34109 79591212
Gastroenteritis 20.15 9.83 13 119054 34069 79591252
Product use issue 20.14 9.83 208 118859 209614 79415707
Ventricular extrasystoles 20.10 9.83 70 118997 19634 79605687
Amnesia 20.09 9.83 162 118905 62895 79562426
Multiple sclerosis relapse 19.98 9.83 24 119043 46509 79578812
Hepatocellular injury 19.95 9.83 25 119042 47568 79577753
Chest pain 19.90 9.83 299 118768 282005 79343316
Postoperative delirium 19.69 9.83 10 119057 353 79624968
Product contamination microbial 19.53 9.83 14 119053 932 79624389
Protein C increased 19.37 9.83 7 119060 104 79625217
Substance dependence 19.26 9.83 11 119056 493 79624828
Restlessness 19.15 9.83 127 118940 46365 79578956
Peritonitis 19.03 9.83 9 119058 28027 79597294
SARS-CoV-2 test negative 18.95 9.83 16 119051 1355 79623966
Osteonecrosis of jaw 18.87 9.83 22 119045 43204 79582117
Transient ischaemic attack 18.82 9.83 31 119036 52664 79572657
Post procedural complication 18.81 9.83 78 118989 23751 79601570
Infusion site discomfort 18.79 9.83 16 119051 1371 79623950
Dermatitis contact 18.75 9.83 47 119020 10986 79614335
Lung neoplasm malignant 18.75 9.83 9 119058 27783 79597538
Sensory loss 18.68 9.83 52 119015 12939 79612382
Coronary artery disease 18.65 9.83 44 119023 65430 79559891
Vasoplegia syndrome 18.64 9.83 25 119042 3605 79621716
Pupillary reflex impaired 18.62 9.83 24 119043 3329 79621992
Balance disorder 18.62 9.83 80 118987 98777 79526544
Harlequin syndrome 18.49 9.83 6 119061 63 79625258
Lymphadenopathy 18.39 9.83 32 119035 53215 79572106
Headache 18.30 9.83 794 118273 652978 78972343
Accidental poisoning 18.24 9.83 17 119050 1640 79623681
Cardiac failure 18.12 9.83 146 118921 154696 79470625
Angina pectoris 17.95 9.83 31 119036 51701 79573620
Prostate cancer 17.95 9.83 14 119053 33254 79592067
Neuromuscular blockade 17.83 9.83 11 119056 569 79624752
Pulmonary embolism 17.80 9.83 167 118900 171487 79453834
Bezoar 17.77 9.83 21 119046 2667 79622654
Brain death 17.68 9.83 31 119036 5646 79619675
Arthritis bacterial 17.68 9.83 41 119026 9125 79616196
Nasal congestion 17.66 9.83 57 119010 76495 79548826
Gait disturbance 17.43 9.83 212 118855 207294 79418027
Impaired driving ability 17.42 9.83 30 119037 5385 79619936
Phrenic nerve paralysis 17.36 9.83 9 119058 332 79624989
Pneumonia 17.23 9.83 808 118259 659438 78965883
Anticholinergic syndrome 17.23 9.83 24 119043 3587 79621734
Bladder cancer 17.21 9.83 4 119063 19522 79605799
Multiple allergies 17.20 9.83 44 119023 10416 79614905
Spinal epidural haemorrhage 17.14 9.83 7 119060 147 79625174
Spinal operation 17.04 9.83 37 119030 7880 79617441
Inappropriate antidiuretic hormone secretion 17.03 9.83 9 119058 26304 79599017
Accidental exposure to product 17.02 9.83 92 118975 31230 79594091
Pain 16.87 9.83 869 118198 702933 78922388
Upper respiratory tract infection 16.76 9.83 209 118858 90959 79534362
Glucose tolerance impaired 16.52 9.83 37 119030 8047 79617274
Metastases to liver 16.47 9.83 11 119056 28303 79597018
Neutropenic sepsis 16.45 9.83 10 119057 27054 79598267
Asthma 16.45 9.83 126 118941 134969 79490352
Dyspepsia 16.43 9.83 95 118972 108592 79516729
Blood lactic acid increased 16.38 9.83 49 119018 12695 79612626
Gastrooesophageal reflux disease 16.37 9.83 90 118977 104156 79521165
Hypercholesterolaemia 16.33 9.83 7 119060 23088 79602233
Paralysis 16.31 9.83 50 119017 13127 79612194
Application site alopecia 16.27 9.83 4 119063 13 79625308
Bradypnoea 16.25 9.83 31 119036 6021 79619300
Haemodynamic instability 16.24 9.83 60 119007 17322 79607999
Myoclonus 16.24 9.83 83 118984 27577 79597744
Full blood count abnormal 16.21 9.83 22 119045 40452 79584869
Tubulointerstitial nephritis 16.12 9.83 20 119047 38215 79587106
Deep vein thrombosis 16.06 9.83 110 118957 120809 79504512
Tracheal deviation 16.05 9.83 7 119060 174 79625147
Stridor 15.98 9.83 29 119038 5424 79619897
Foreign body in respiratory tract 15.91 9.83 9 119058 396 79624925
Eosinophilia 15.89 9.83 27 119040 45318 79580003
Hip arthroplasty 15.82 9.83 18 119049 35738 79589583
Axillary nerve injury 15.82 9.83 4 119063 15 79625306
Inflammation 15.81 9.83 79 118988 93674 79531647
Prescribed overdose 15.78 9.83 20 119047 37863 79587458
Uveitis 15.76 9.83 3 119064 16827 79608494
Nail bed tenderness 15.72 9.83 9 119058 405 79624916
Catecholamine crisis 15.72 9.83 5 119062 49 79625272
Intracranial hypotension 15.68 9.83 9 119058 407 79624914
Areflexia 15.68 9.83 29 119038 5505 79619816
Hypocalcaemia 15.49 9.83 32 119035 49892 79575429
Dyspnoea exertional 15.48 9.83 72 118995 87001 79538320
Delirium tremens 15.41 9.83 11 119056 727 79624594
Visceral oedema 15.39 9.83 6 119061 111 79625210
Brain stem syndrome 15.29 9.83 12 119055 916 79624405
Pancreatitis acute 15.22 9.83 32 119035 49572 79575749
Behavioural addiction 15.20 9.83 5 119062 55 79625266
Induced abortion failed 15.18 9.83 7 119060 199 79625122
Brachial plexus injury 15.10 9.83 6 119061 117 79625204
International normalised ratio increased 15.09 9.83 70 118997 84651 79540670
Jaundice 15.07 9.83 36 119031 53313 79572008
Substance-induced mood disorder 15.01 9.83 6 119061 119 79625202
Progressive multifocal leukoencephalopathy 14.95 9.83 6 119061 20594 79604727
Trigeminal palsy 14.90 9.83 4 119063 20 79625301
Incision site rash 14.90 9.83 4 119063 20 79625301
Physical assault 14.86 9.83 15 119052 1596 79623725
Anaphylactoid shock 14.85 9.83 11 119056 770 79624551
Neuropathy peripheral 14.85 9.83 137 118930 141168 79484153
Immunodeficiency 14.76 9.83 7 119060 21761 79603560
Diabetes mellitus inadequate control 14.70 9.83 9 119058 24255 79601066
Drug eruption 14.64 9.83 27 119040 43908 79581413
Procedural complication 14.62 9.83 35 119032 7948 79617373
Red blood cell count decreased 14.57 9.83 41 119026 57472 79567849
Infusion site nodule 14.52 9.83 8 119059 334 79624987
Neoplasm progression 14.50 9.83 35 119032 51647 79573674
Spinal epidural haematoma 14.45 9.83 14 119053 1418 79623903
Intentional dose omission 14.40 9.83 37 119030 8780 79616541
Proctalgia 14.35 9.83 40 119027 9961 79615360
Accelerated idioventricular rhythm 14.25 9.83 7 119060 230 79625091
Psychiatric disorder prophylaxis 14.24 9.83 5 119062 68 79625253
Respiratory tract infection viral 14.24 9.83 24 119043 4235 79621086
Ventricular hypokinesia 14.20 9.83 38 119029 9241 79616080
Infusion site rash 14.17 9.83 15 119052 1687 79623634
Skin exfoliation 14.17 9.83 39 119028 55061 79570260
Pulmonary toxicity 14.16 9.83 47 119020 12867 79612454
Palpitations 14.07 9.83 121 118946 126489 79498832
Haematotoxicity 14.04 9.83 3 119064 15516 79609805
Hypoxic-ischaemic encephalopathy 14.02 9.83 34 119033 7786 79617535
Abortion spontaneous 14.01 9.83 14 119053 29493 79595828
Irregular breathing 13.86 9.83 9 119058 509 79624812
Colitis ulcerative 13.80 9.83 19 119048 34723 79590598
Sexual abuse 13.79 9.83 7 119060 247 79625074
Mean arterial pressure decreased 13.70 9.83 8 119059 374 79624947
Myelodysplastic syndrome 13.69 9.83 15 119052 30286 79595035
Opisthotonus 13.68 9.83 10 119057 686 79624635
Metastases to lung 13.67 9.83 5 119062 18158 79607163
Oxidative stress 13.64 9.83 4 119063 29 79625292
Brain injury 13.61 9.83 43 119024 11474 79613847
Vitreous disorder 13.61 9.83 7 119060 254 79625067
Fall 13.46 9.83 593 118474 487036 79138285
Foreign body 13.46 9.83 19 119048 2875 79622446
Spinal cord oedema 13.45 9.83 8 119059 387 79624934
Graft versus host disease 13.40 9.83 3 119064 15023 79610298
Angina unstable 13.40 9.83 4 119063 16523 79608798
Injection site ulcer 13.39 9.83 10 119057 709 79624612
Gastric disorder 13.38 9.83 22 119045 37411 79587910
Glycosylated haemoglobin increased 13.36 9.83 6 119061 19254 79606067
Euphoric mood 13.22 9.83 33 119034 7693 79617628
Acute pulmonary oedema 13.20 9.83 49 119018 14181 79611140
Muscular weakness 13.20 9.83 165 118902 160564 79464757
Injection site reaction 13.19 9.83 40 119027 54745 79570576
Injection site joint infection 13.18 9.83 4 119063 33 79625288
Blood glucose increased 13.18 9.83 109 118958 114866 79510455
Foot deformity 13.15 9.83 10 119057 24064 79601257
Vaginal abscess 13.14 9.83 8 119059 404 79624917
Left ventricle outflow tract obstruction 13.12 9.83 8 119059 405 79624916
Familial periodic paralysis 13.07 9.83 6 119061 169 79625152
Creatinine renal clearance decreased 13.05 9.83 6 119061 18996 79606325
Spinal stroke 12.98 9.83 4 119063 35 79625286
Implant site bruising 12.89 9.83 7 119060 284 79625037
Intentional product misuse to child 12.85 9.83 5 119062 92 79625229
Skin lesion 12.83 9.83 27 119040 41817 79583504
Eczema 12.80 9.83 26 119041 40792 79584529
Rheumatoid nodule 12.79 9.83 5 119062 17433 79607888
Infusion site irritation 12.75 9.83 10 119057 763 79624558
Reperfusion arrhythmia 12.69 9.83 7 119060 293 79625028
Toxic epidermal necrolysis 12.66 9.83 30 119037 44551 79580770
Peripheral venous disease 12.63 9.83 4 119063 15905 79609416
Alcoholic pancreatitis 12.53 9.83 6 119061 186 79625135
Cholestasis of pregnancy 12.53 9.83 11 119056 982 79624339
Femoral nerve injury 12.50 9.83 4 119063 40 79625281
Upper gastrointestinal haemorrhage 12.44 9.83 27 119040 41353 79583968
Vitamin D increased 12.44 9.83 9 119058 608 79624713
Anaphylactoid reaction 12.43 9.83 26 119041 5396 79619925
Paranasal cyst 12.41 9.83 8 119059 447 79624874
Sleep disorder 12.36 9.83 76 118991 85601 79539720
Hepatic fibrosis 12.36 9.83 31 119036 7249 79618072
Ventricular arrhythmia 12.33 9.83 35 119032 8805 79616516
Palmar-plantar erythrodysaesthesia syndrome 12.29 9.83 19 119048 33115 79592206
Symblepharon 12.27 9.83 6 119061 195 79625126
Heliotrope rash 12.24 9.83 6 119061 196 79625125
Gastritis alcoholic 12.24 9.83 4 119063 43 79625278
Injection site discharge 12.21 9.83 10 119057 812 79624509
Body dysmorphic disorder 12.17 9.83 7 119060 318 79625003
Fibromyalgia 12.16 9.83 52 119015 64288 79561033
Non-cardiogenic pulmonary oedema 12.11 9.83 13 119054 1486 79623835
Anal skin tags 12.06 9.83 8 119059 469 79624852
Neuroleptic malignant syndrome 12.06 9.83 14 119053 27545 79597776
Cerebral haemorrhage 11.92 9.83 45 119022 57628 79567693
Delirium 11.90 9.83 185 118882 84442 79540879
Wheezing 11.88 9.83 114 118953 116550 79508771
Benzodiazepine drug level therapeutic 11.85 9.83 4 119063 48 79625273
Alcoholic 11.85 9.83 4 119063 48 79625273
Lymphopenia 11.85 9.83 17 119050 30540 79594781
Acute myocardial infarction 11.82 9.83 67 119000 76969 79548352
Femur fracture 11.80 9.83 25 119042 38627 79586694
Suicidal behaviour 11.80 9.83 19 119048 3228 79622093
Airway peak pressure increased 11.76 9.83 7 119060 339 79624982
Pulmonary congestion 11.75 9.83 75 118992 27025 79598296
Staphylococcal infection 11.75 9.83 136 118931 58159 79567162
Neutrophil count decreased 11.73 9.83 87 118980 93872 79531449
Apnoeic attack 11.73 9.83 9 119058 665 79624656
Vascular resistance systemic decreased 11.63 9.83 6 119061 219 79625102
Blood pressure decreased 11.63 9.83 211 118856 99255 79526066
Myokymia 11.63 9.83 5 119062 120 79625201
Pain in jaw 11.62 9.83 33 119034 46118 79579203
Pancreatic carcinoma 11.54 9.83 3 119064 13574 79611747
Abnormal sleep-related event 11.52 9.83 10 119057 879 79624442
Thrombotic microangiopathy 11.51 9.83 8 119059 20161 79605160
Premature delivery 11.48 9.83 67 119000 23400 79601921
Poor quality product administered 11.47 9.83 20 119047 3625 79621696
Device expulsion 11.46 9.83 13 119054 25848 79599473
Therapeutic response decreased 11.46 9.83 56 119011 66797 79558524
Drug ineffective for unapproved indication 11.45 9.83 122 118945 51116 79574205
Streptococcal infection 11.40 9.83 34 119033 8796 79616525
Infusion site streaking 11.33 9.83 8 119059 520 79624801
Injection site bruising 11.32 9.83 28 119039 40974 79584347
Nerve block 11.28 9.83 9 119058 704 79624617
Throat irritation 11.28 9.83 28 119039 40918 79584403
Visual acuity reduced 11.24 9.83 79 118988 29390 79595931
Anal ulcer 11.22 9.83 12 119055 1366 79623955
Coccygectomy 11.17 9.83 3 119064 15 79625306
Rash pruritic 11.15 9.83 62 119005 71567 79553754
Foetal heart rate abnormal 11.09 9.83 7 119060 377 79624944
Haemorrhoids 11.06 9.83 78 118989 29050 79596271
Haematuria 11.04 9.83 59 119008 68777 79556544
Gun shot wound 10.99 9.83 11 119056 1159 79624162
Myalgia 10.98 9.83 203 118864 185438 79439883
Transferrin decreased 10.97 9.83 7 119060 384 79624937
Liquid product physical issue 10.96 9.83 11 119056 1163 79624158
Enterocolitis 10.91 9.83 4 119063 14508 79610813
Fatty liver alcoholic 10.85 9.83 4 119063 63 79625258
Chest discomfort 10.85 9.83 143 118924 137901 79487420
Eosinophil count increased 10.85 9.83 6 119061 17099 79608222
Lung disorder 10.84 9.83 73 118994 80484 79544837
Coma scale abnormal 10.81 9.83 33 119034 8645 79616676
Drug tolerance decreased 10.78 9.83 3 119064 12975 79612346
Myotonic dystrophy 10.72 9.83 5 119062 146 79625175
Myopathy 10.66 9.83 9 119058 20554 79604767
Intraocular pressure fluctuation 10.63 9.83 4 119063 67 79625254
Hepatitis C virus test positive 10.56 9.83 7 119060 410 79624911
Repetitive strain injury 10.54 9.83 5 119062 152 79625169
Stab wound 10.46 9.83 6 119061 271 79625050
Kidney infection 10.44 9.83 62 119005 21789 79603532
Stress 10.43 9.83 172 118895 79440 79545881
Ascites 10.40 9.83 68 118999 75494 79549827
Drug diversion 10.38 9.83 11 119056 1239 79624082
Retrograde amnesia 10.35 9.83 8 119059 597 79624724
Corneal opacity 10.34 9.83 10 119057 1010 79624311
Vascular stenosis 10.34 9.83 8 119059 598 79624723
Full blood count decreased 10.32 9.83 15 119052 26804 79598517
Oesophageal obstruction 10.29 9.83 10 119057 1016 79624305
Postmortem blood drug level increased 10.28 9.83 9 119058 800 79624521
Sinus arrest 10.28 9.83 19 119048 3603 79621718
Haemolytic anaemia 10.26 9.83 7 119060 17813 79607508
Brachial artery entrapment syndrome 10.26 9.83 4 119063 74 79625247
Insomnia 10.26 9.83 283 118784 244887 79380434
Eyelid ptosis 10.22 9.83 38 119029 11006 79614315
Hypoaesthesia oral 10.20 9.83 45 119022 14079 79611242
Abdominal pain lower 10.18 9.83 20 119047 31762 79593559
Air embolism 10.12 9.83 7 119060 440 79624881
Hepatitis cholestatic 10.11 9.83 4 119063 13848 79611473
Immune reconstitution inflammatory syndrome 10.10 9.83 4 119063 13837 79611484
Osteoporosis 10.06 9.83 44 119023 54068 79571253
Photosensitivity reaction 10.06 9.83 10 119057 21117 79604204
Spinal cord injury 10.06 9.83 11 119056 1284 79624037
Fluid retention 10.03 9.83 62 119005 69747 79555574
Panniculitis 10.02 9.83 3 119064 12368 79612953
Dry skin 9.97 9.83 60 119007 67935 79557386
Incision site swelling 9.94 9.83 6 119061 298 79625023
Liver function test abnormal 9.94 9.83 56 119011 64419 79560902
Cardiac death 9.92 9.83 12 119055 1562 79623759
Device ineffective 9.91 9.83 5 119062 174 79625147
Hypothermia 9.89 9.83 63 119004 22683 79602638
Stevens-Johnson syndrome 9.86 9.83 28 119039 39138 79586183
Cerebral infarction 9.86 9.83 35 119032 45641 79579680
Rectal haemorrhage 9.84 9.83 70 118997 76230 79549091
Orbital infection 9.84 9.83 4 119063 83 79625238
Renal cancer 9.84 9.83 3 119064 12223 79613098
Tracheitis 9.83 9.83 11 119056 1317 79624004

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 53.98 21.16 9 5 72 89706

Pharmacologic Action:

SourceCodeDescription
ATC D08AJ01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA05 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC D09AA11 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA16 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
CHEBI has role CHEBI:27780 Detergents
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35195 surfactant
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D010592 Pharmaceutic Aids
MeSH PA D011310 Preservatives, Pharmaceutical
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:51076 Marine pesticide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Uveitis indication 128473001 DOID:13141
Skin irritation indication 367466007
Local anesthesia indication 386761002
Allergic otitis externa indication 405821001
Itching of skin indication 418363000
Itching of ear indication 699392007
Post-Op Ocular Inflammation indication
Suppression of the Gag Reflex indication
Mouth Irritation indication
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Bacterial septicemia contraindication 10001005 DOID:0040085
Hypocupremia contraindication 19577007
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Shock contraindication 27942005
Methemoglobinemia contraindication 38959009 DOID:10783
Conduction disorder of the heart contraindication 44808001
Perforation of tympanic membrane contraindication 60442001
Diabetes mellitus contraindication 73211009 DOID:9351
Decreased respiratory function contraindication 80954004
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Peripheral vascular disease contraindication 400047006
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018249 VUID
N0000178890 NUI
D00857 KEGG_DRUG
8001-54-5 SECONDARY_CAS_RN
4018249 VANDF
4023321 VANDF
C0005025 UMLSCUI
CHEBI:3020 CHEBI
CHEMBL1187417 ChEMBL_ID
CHEMBL502109 ChEMBL_ID
CHEMBL1907001 ChEMBL_ID
D001548 MESH_DESCRIPTOR_UI
DB11105 DRUGBANK_ID
7N6JUD5X6Y UNII
2330 PUBCHEM_CID
DB13282 DRUGBANK_ID
1311593 RXNORM
4255 MMSL
5003 MMSL
003141 NDDF
005466 NDDF
006369 NDDF
373549009 SNOMEDCT_US
64686009 SNOMEDCT_US
735078001 SNOMEDCT_US
90370005 SNOMEDCT_US
1168 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Stay Safe Hand Sanitizer Alcohol Free HUMAN OTC DRUG LABEL 1 0295-9049 GEL 0.13 mg TOPICAL OTC monograph not final 10 sections
Hand wash HUMAN OTC DRUG LABEL 1 0363-0082 SOAP 1.30 mg TOPICAL OTC monograph not final 11 sections
Hand wash HUMAN OTC DRUG LABEL 1 0363-0082 SOAP 1.30 mg TOPICAL OTC monograph not final 11 sections
Hand wash HUMAN OTC DRUG LABEL 1 0363-0082 SOAP 1.30 mg TOPICAL OTC monograph not final 11 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-0242 SOAP 130 mg TOPICAL OTC monograph not final 12 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-0242 SOAP 130 mg TOPICAL OTC monograph not final 12 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-0242 SOAP 130 mg TOPICAL OTC monograph not final 12 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Nicefresh scent HUMAN OTC DRUG LABEL 1 0363-0554 CLOTH 0.12 g TOPICAL OTC monograph not final 11 sections
First Aid Antiseptic Wipes HUMAN OTC DRUG LABEL 1 0363-0589 CLOTH 0.00 mg TOPICAL OTC monograph not final 11 sections
First Aid Antiseptic Wipes HUMAN OTC DRUG LABEL 1 0363-0589 CLOTH 0.00 mg TOPICAL OTC monograph not final 11 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.13 g ORAL OTC monograph not final 9 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.13 g ORAL OTC monograph not final 9 sections
Hand wipes HUMAN OTC DRUG LABEL 1 0363-0644 CLOTH 1.30 g TOPICAL OTC monograph not final 12 sections
Hand wipes HUMAN OTC DRUG LABEL 1 0363-0644 CLOTH 1.30 g TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0651 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0651 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0683 LIQUID 1.30 mg TOPICAL OTC monograph not final 11 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0683 LIQUID 1.30 mg TOPICAL OTC monograph not final 11 sections
PM Toothache Relief HUMAN OTC DRUG LABEL 4 0363-1623 PASTE 0.26 g DENTAL OTC monograph not final 8 sections
Antibacterial Lidocaine Wound Gel HUMAN OTC DRUG LABEL 2 0363-1652 GEL 0.13 g TOPICAL OTC monograph not final 12 sections
First Aid AntisepticWell at Walgreens HUMAN OTC DRUG LABEL 2 0363-3286 SPRAY 0.13 g TOPICAL OTC monograph not final 11 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.13 g ORAL OTC monograph not final 9 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.13 g ORAL OTC monograph not final 9 sections
Walgreen Maximum strengthpain relieving cleansing HUMAN OTC DRUG LABEL 2 0363-7020 LIQUID 0.13 g TOPICAL OTC monograph not final 14 sections
Walgreen Maximum strengthpain relieving cleansing HUMAN OTC DRUG LABEL 2 0363-7020 LIQUID 0.13 g TOPICAL OTC monograph not final 14 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0363-7110 LIQUID 1.25 g TOPICAL OTC monograph not final 11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL HUMAN OTC DRUG LABEL 1 0363-7210 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
WalgreensANTIBACTERIAL HAND REFILL HUMAN OTC DRUG LABEL 1 0363-7211 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections