All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

benzalkonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quaternary ammonium compounds	3017	139-07-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzalkonium chloride benzalkonium benzyldodecyldimethylammonium chloride benzododecinium	A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics. Molecular weight: 304.54 Formula: C21H38N CLOGP: 3.18 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: ALOGS: -7.85 ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	3410.74	9.93	2268	87154	143405	63256195
Toxicity to various agents	2128.44	9.93	2149	87273	245101	63154499
Drug abuse	1129.35	9.93	884	88538	71634	63327966
Cardio-respiratory arrest	726.18	9.93	632	88790	59327	63340273
Intentional overdose	521.79	9.93	581	88841	73571	63326029
Local anaesthetic systemic toxicity	450.39	9.93	125	89297	774	63398826
Overdose	405.08	9.93	642	88780	114436	63285164
Cardiac arrest	383.34	9.93	557	88865	91988	63307612
Alcohol interaction	325.70	9.93	124	89298	2285	63397315
Suicide attempt	274.77	9.93	382	89040	60536	63339064
Suspected suicide	252.44	9.93	141	89281	6427	63393173
Pemphigus	223.31	9.93	8	89414	183718	63215882
Toxic anterior segment syndrome	217.46	9.93	85	89337	1686	63397914
Sinusitis	208.32	9.93	747	88675	225906	63173694
Glossodynia	194.94	9.93	15	89407	178861	63220739
Methaemoglobinaemia	192.41	9.93	85	89337	2318	63397282
Hand deformity	190.17	9.93	8	89414	159449	63240151
Respiratory arrest	184.83	9.93	229	89193	32416	63367184
Synovitis	179.73	9.93	25	89397	186893	63212707
Systemic lupus erythematosus	176.80	9.93	39	89383	208879	63190721
Alcohol poisoning	173.65	9.93	74	89348	1845	63397755
Infusion site pain	165.21	9.93	158	89264	16711	63382889
Alopecia	152.97	9.93	150	89272	337386	63062214
Death	152.11	9.93	974	88448	373407	63026193
Exposure to toxic agent	152.05	9.93	96	89326	5491	63394109
Anti-cyclic citrullinated peptide antibody positive	148.83	9.93	3	89419	116209	63283391
Infusion site extravasation	146.83	9.93	120	89302	10306	63389294
Abdominal discomfort	141.50	9.93	146	89276	320739	63078861
Intentional product misuse	139.57	9.93	282	89140	60635	63338965
Infusion site swelling	136.64	9.93	112	89310	9658	63389942
Alcohol use	133.28	9.93	63	89359	2016	63397584
Infusion site pruritus	133.28	9.93	91	89331	5944	63393656
Contraindicated product administered	130.55	9.93	72	89350	217576	63182024
Wound	129.28	9.93	35	89387	163228	63236372
Infusion site haemorrhage	127.53	9.93	83	89339	5003	63394597
COVID-19	126.97	9.93	399	89023	112704	63286896
Kounis syndrome	125.14	9.93	57	89365	1673	63397927
Pericarditis	123.20	9.93	19	89403	131560	63268040
Infusion site erythema	115.52	9.93	110	89312	11569	63388031
Maternal exposure during delivery	113.50	9.93	51	89371	1449	63398151
Drug intolerance	112.25	9.93	163	89259	308498	63091102
Joint swelling	111.53	9.93	181	89241	327485	63072115
Gastrointestinal toxicity	108.80	9.93	89	89333	7652	63391948
Hepatic enzyme increased	106.15	9.93	78	89344	202250	63197350
Drug ineffective	105.59	9.93	954	88468	1043811	62355789
Duodenal ulcer perforation	105.21	9.93	4	89418	87205	63312395
Rheumatoid factor positive	104.92	9.93	3	89419	84403	63315197
Alcohol abuse	104.71	9.93	54	89368	2092	63397508
Anaesthetic complication	103.44	9.93	52	89370	1908	63397692
Seasonal allergy	95.32	9.93	132	89290	20818	63378782
General physical health deterioration	90.56	9.93	90	89332	201312	63198288
Pulmonary toxicity	89.64	9.93	87	89335	9368	63390232
Mydriasis	87.97	9.93	96	89326	11860	63387740
Diarrhoea	87.85	9.93	619	88803	714747	62684853
Therapy interrupted	87.49	9.93	161	89261	32294	63367306
Anaphylactic reaction	86.26	9.93	246	89176	65854	63333746
Infusion site bruising	85.14	9.93	58	89364	3774	63395826
Generalised tonic-clonic seizure	84.68	9.93	149	89273	28867	63370733
Seizure	84.10	9.93	390	89032	132244	63267356
Swelling	82.11	9.93	165	89257	275213	63124387
Incorrect drug administration rate	81.05	9.93	57	89365	3905	63395695
Therapeutic product effect decreased	79.44	9.93	93	89329	193094	63206506
Anaphylactic shock	79.09	9.93	129	89293	23504	63376096
Rash	77.54	9.93	468	88954	560403	62839197
Pulseless electrical activity	76.60	9.93	72	89350	7449	63392151
Insurance issue	74.95	9.93	65	89357	6056	63393544
Folliculitis	73.54	9.93	7	89415	70310	63329290
Coma	73.04	9.93	228	89194	64136	63335464
Ear infection	69.30	9.93	161	89261	38052	63361548
Rheumatoid arthritis	65.91	9.93	164	89258	253655	63145945
Somnolence	65.75	9.93	454	88968	178231	63221369
Arthropathy	64.70	9.93	147	89275	234645	63164955
Agitation	64.44	9.93	208	89214	59549	63340051
Illness	63.43	9.93	182	89240	48877	63350723
Helicobacter infection	62.76	9.93	26	89396	92759	63306841
Arthralgia	61.76	9.93	510	88912	569200	62830400
Impaired healing	61.32	9.93	34	89388	102508	63297092
Poisoning deliberate	59.20	9.93	76	89346	11142	63388458
Blister	58.33	9.93	58	89364	129756	63269844
Discomfort	58.24	9.93	91	89331	167283	63232317
Loss of consciousness	57.80	9.93	323	89099	117798	63281802
Muscle injury	57.71	9.93	11	89411	65334	63334266
Corneal oedema	57.23	9.93	32	89390	1461	63398139
Bradycardia	56.89	9.93	229	89193	72998	63326602
Psoriatic arthropathy	56.70	9.93	29	89393	91491	63308109
Extradural abscess	55.82	9.93	27	89395	910	63398690
Postmortem blood drug level abnormal	54.12	9.93	20	89402	338	63399262
Upper respiratory tract infection	54.01	9.93	244	89178	81803	63317797
Alcoholism	53.92	9.93	33	89389	1785	63397815
Ventricular tachycardia	53.70	9.93	99	89323	19880	63379720
Infusion site urticaria	52.60	9.93	31	89391	1565	63398035
Infusion site mass	52.47	9.93	34	89388	2034	63397566
Unresponsive to stimuli	52.28	9.93	134	89288	33682	63365918
Anaesthetic complication neurological	52.21	9.93	18	89404	246	63399354
Blood alcohol increased	52.00	9.93	23	89399	629	63398971
Hypersensitivity	51.81	9.93	224	89198	292461	63107139
Product use issue	51.56	9.93	150	89272	220370	63179230
Tachycardia	51.26	9.93	313	89109	117843	63281757
Electrocardiogram ST segment elevation	50.72	9.93	43	89379	3884	63395716
Body tinea	50.32	9.93	32	89390	1853	63397747
Neoplasm malignant	50.02	9.93	122	89300	29739	63369861
Stress cardiomyopathy	49.83	9.93	64	89358	9386	63390214
Substance abuse	48.92	9.93	46	89376	4761	63394839
Hypotension	48.09	9.93	591	88831	272013	63127587
Procedural hypotension	46.96	9.93	26	89396	1164	63398436
Rheumatic fever	45.86	9.93	4	89418	43107	63356493
Asthenia	44.93	9.93	336	89086	383268	63016332
Victim of sexual abuse	44.68	9.93	21	89401	663	63398937
Incorrect route of product administration	43.70	9.93	110	89312	27342	63372258
Chemical submission	43.53	9.93	16	89406	266	63399334
Extradural haematoma	42.92	9.93	28	89394	1694	63397906
Pulse absent	42.79	9.93	45	89377	5329	63394271
Bronchitis	42.76	9.93	312	89110	124623	63274977
Systemic toxicity	42.73	9.93	12	89410	78	63399522
Respiratory tract infection	42.57	9.93	142	89280	41341	63358259
Joint injury	41.46	9.93	113	89309	29459	63370141
Off label use	41.36	9.93	685	88737	673777	62725823
Neutropenia	40.93	9.93	119	89303	174886	63224714
Poisoning	40.81	9.93	71	89351	13629	63385971
Stomatitis	40.55	9.93	84	89338	138641	63260959
Respiratory depression	39.46	9.93	70	89352	13645	63385955
Acute kidney injury	39.39	9.93	214	89208	263201	63136399
Lagophthalmos	39.31	9.93	16	89406	354	63399246
Mobility decreased	39.23	9.93	69	89353	121090	63278510
Infusion site rash	39.20	9.93	28	89394	1966	63397634
Urinary tract infection	38.84	9.93	555	88867	264129	63135471
Disease progression	37.88	9.93	72	89350	122686	63276914
Sinus tachycardia	37.34	9.93	96	89326	24172	63375428
Ventricular fibrillation	37.32	9.93	63	89359	11804	63387796
Myocarditis	36.79	9.93	58	89364	10267	63389333
Inhibitory drug interaction	36.40	9.93	31	89391	2818	63396782
Lower respiratory tract infection	36.28	9.93	83	89339	132224	63267376
Nystagmus	35.78	9.93	44	89378	6176	63393424
Loss of personal independence in daily activities	35.66	9.93	51	89371	97239	63302361
Hepatotoxicity	35.55	9.93	124	89298	36917	63362683
Mental status changes	34.97	9.93	129	89293	39470	63360130
Product adhesion issue	34.91	9.93	38	89384	4681	63394919
Pneumocephalus	34.54	9.93	12	89410	168	63399432
Hypopyon	34.51	9.93	18	89404	714	63398886
Apnoea	34.20	9.93	49	89373	7973	63391627
Staphylococcal infection	33.63	9.93	131	89291	41125	63358475
Abdominal pain upper	32.94	9.93	164	89258	206280	63193320
Multiple allergies	32.91	9.93	65	89357	13737	63385863
Dermatitis contact	32.72	9.93	57	89365	10951	63388649
Dyspnoea	32.66	9.93	697	88725	660616	62738984
Infection susceptibility increased	32.63	9.93	32	89390	3489	63396111
Peripheral swelling	32.52	9.93	230	89192	265712	63133888
Thrombocytopenia	32.35	9.93	107	89315	151050	63248550
Vitritis	31.99	9.93	19	89403	973	63398627
Kidney infection	31.93	9.93	88	89334	23088	63376512
Administration site pain	31.91	9.93	18	89404	836	63398764
Ill-defined disorder	31.84	9.93	41	89381	81714	63317886
Pain	31.71	9.93	798	88624	739830	62659770
Bursitis infective	31.44	9.93	21	89401	1322	63398278
Prescribed underdose	30.92	9.93	3	89419	29686	63369914
Embolia cutis medicamentosa	30.67	9.93	14	89408	413	63399187
Anterior chamber cell	30.38	9.93	15	89407	529	63399071
Fear	30.32	9.93	68	89354	15698	63383902
Corneal epithelium defect	29.96	9.93	13	89409	339	63399261
Drug use disorder	29.88	9.93	36	89386	4948	63394652
Infusion site nodule	29.44	9.93	21	89401	1471	63398129
Electrocardiogram QRS complex prolonged	29.42	9.93	39	89383	5899	63393701
Platelet aggregation inhibition	29.32	9.93	10	89412	132	63399468
Cauda equina syndrome	29.24	9.93	18	89404	984	63398616
Product administration interrupted	29.10	9.93	35	89387	4801	63394799
Purtscher retinopathy	28.74	9.93	9	89413	89	63399511
Fear of eating	28.62	9.93	13	89409	379	63399221
Aggression	28.29	9.93	85	89337	23413	63376187
Treatment failure	27.96	9.93	165	89257	198878	63200722
Parophthalmia	27.73	9.93	12	89410	311	63399289
Administration site swelling	27.19	9.93	19	89403	1288	63398312
Retinal vasculitis	27.16	9.93	17	89405	957	63398643
Unevaluable event	26.78	9.93	143	89279	51243	63348357
Endophthalmitis	26.70	9.93	29	89393	3563	63396037
Aqueous fibrin	26.52	9.93	8	89414	69	63399531
C-reactive protein increased	26.29	9.93	59	89363	94648	63304952
Drug interaction	26.23	9.93	461	88961	228670	63170930
Hyponatraemia	26.21	9.93	76	89346	111824	63287776
Drug dependence	26.18	9.93	85	89337	24398	63375202
COVID-19 immunisation	26.07	9.93	21	89401	1766	63397834
Surgery	26.06	9.93	110	89312	35802	63363798
Type I hypersensitivity	25.90	9.93	26	89396	2916	63396684
Fatigue	25.80	9.93	1007	88415	887021	62512579
Irritable bowel syndrome	25.72	9.93	48	89374	82364	63317236
Substance use disorder	25.64	9.93	10	89412	197	63399403
Cardiogenic shock	25.61	9.93	69	89353	17863	63381737
Status epilepticus	25.26	9.93	62	89360	15171	63384429
Anal skin tags	25.06	9.93	13	89409	510	63399090
Glucose tolerance impaired	24.91	9.93	38	89384	6539	63393061
Pancytopenia	24.83	9.93	63	89359	96870	63302730
Orthostatic hypotension	24.66	9.93	10	89412	36150	63363450
Renal injury	24.40	9.93	46	89376	9393	63390207
Hip arthroplasty	24.15	9.93	19	89403	47627	63351973
Peripheral nerve injury	23.90	9.93	12	89410	439	63399161
Type 2 diabetes mellitus	23.88	9.93	33	89389	63835	63335765
Product dose omission issue	23.88	9.93	463	88959	233850	63165750
Somnambulism	23.84	9.93	34	89388	5509	63394091
Cardiac failure congestive	23.74	9.93	60	89362	92373	63307227
Spinal epidural haemorrhage	23.71	9.93	8	89414	102	63399498
Abdominal pain	23.61	9.93	282	89140	293174	63106426
Septic arthritis staphylococcal	23.36	9.93	12	89410	461	63399139
Protein C increased	23.09	9.93	8	89414	111	63399489
Cyanosis	23.03	9.93	64	89358	16871	63382729
Pulmonary oedema	22.92	9.93	144	89278	54729	63344871
Drug level increased	22.59	9.93	77	89345	22659	63376941
Septic shock	22.43	9.93	37	89385	66592	63333008
Leukopenia	22.41	9.93	47	89375	77243	63322357
Congestive hepatopathy	22.30	9.93	24	89398	2918	63396682
Malignant neoplasm progression	22.12	9.93	52	89370	82069	63317531
Drug reaction with eosinophilia and systemic symptoms	22.05	9.93	10	89412	33826	63365774
Victim of chemical submission	22.03	9.93	12	89410	520	63399080
Anhedonia	21.86	9.93	48	89374	10926	63388674
Nerve root injury	21.50	9.93	6	89416	38	63399562
Upper airway obstruction	21.46	9.93	13	89409	690	63398910
Anaemia	21.35	9.93	288	89134	293142	63106458
Atonic urinary bladder	21.21	9.93	7	89415	83	63399517
Blood cholesterol increased	21.20	9.93	65	89357	93967	63305633
Infusion site discomfort	21.11	9.93	17	89405	1429	63398171
Drug withdrawal syndrome	21.07	9.93	85	89337	27109	63372491
Spinal anaesthesia	20.98	9.93	6	89416	42	63399558
Ophthalmoplegia	20.93	9.93	17	89405	1447	63398153
Normal newborn	20.76	9.93	40	89382	8301	63391299
Ventricular hypokinesia	20.73	9.93	29	89393	4615	63394985
Femur fracture	20.72	9.93	17	89405	41739	63357861
Skin infection	20.70	9.93	57	89365	14945	63384655
Meningitis chemical	20.59	9.93	8	89414	156	63399444
Miosis	20.47	9.93	37	89385	7316	63392284
Punctate keratitis	20.30	9.93	12	89410	609	63398991
Bundle branch block left	20.27	9.93	36	89386	7023	63392577
Trigemino-cardiac reflex	20.18	9.93	6	89416	49	63399551
Depressed level of consciousness	20.07	9.93	153	89269	61925	63337675
Device infusion issue	19.78	9.93	19	89403	2019	63397581
Homicide	19.69	9.93	10	89412	375	63399225
Psoriasis	19.68	9.93	60	89362	86897	63312703
Shock	19.52	9.93	75	89347	23388	63376212
Inappropriate schedule of product administration	19.43	9.93	228	89194	103737	63295863
Neuromuscular block prolonged	19.11	9.93	11	89411	531	63399069
Infusion site discolouration	19.11	9.93	13	89409	844	63398756
Abortion spontaneous	19.07	9.93	23	89399	47172	63352428
Substance dependence	18.90	9.93	8	89414	196	63399404
Cholestasis	18.72	9.93	9	89413	29425	63370175
Condition aggravated	18.62	9.93	428	88994	401789	62997811
Infusion site reaction	18.45	9.93	24	89398	3563	63396037
Gastroenteritis viral	18.30	9.93	74	89348	23626	63375974
Eyelid ptosis	18.27	9.93	35	89387	7232	63392368
Red blood cell sedimentation rate increased	18.24	9.93	21	89401	43961	63355639
Neurotoxicity	18.18	9.93	59	89363	16931	63382669
Haemoglobin decreased	18.16	9.93	125	89297	145360	63254240
Infusion site irritation	18.15	9.93	13	89409	917	63398683
Spinal epidural haematoma	18.07	9.93	14	89408	1113	63398487
Decreased appetite	18.05	9.93	247	89175	250805	63148795
Postmortem blood drug level	18.04	9.93	7	89415	136	63399464
Post procedural complication	18.01	9.93	59	89363	17015	63382585
Glossoptosis	17.82	9.93	6	89416	76	63399524
Obesity	17.80	9.93	10	89412	29942	63369658
Nerve block	17.76	9.93	12	89410	770	63398830
Respiratory acidosis	17.70	9.93	33	89389	6682	63392918
Poor quality sleep	17.65	9.93	65	89357	19870	63379730
Pulmonary fibrosis	17.63	9.93	18	89404	39791	63359809
Spinal operation	17.41	9.93	37	89385	8234	63391366
Circulatory collapse	17.34	9.93	69	89353	21869	63377731
Stridor	17.31	9.93	23	89399	3487	63396113
Induced abortion failed	17.28	9.93	8	89414	244	63399356
Paraplegia	17.17	9.93	20	89402	2652	63396948
White blood cell count decreased	17.13	9.93	120	89302	138984	63260616
Hypoxia	16.95	9.93	143	89279	59649	63339951
Blood creatinine increased	16.91	9.93	65	89357	87779	63311821
Eye infarction	16.90	9.93	5	89417	40	63399560
Haematochezia	16.87	9.93	31	89391	53513	63346087
Intentional dose omission	16.86	9.93	36	89386	8039	63391561
Interstitial lung disease	16.83	9.93	39	89383	61869	63337731
Electrocardiogram QT prolonged	16.68	9.93	142	89280	59388	63340212
Accidental overdose	16.60	9.93	71	89351	23238	63376362
Removal of foreign body	16.59	9.93	5	89417	43	63399557
Accidental death	16.55	9.93	17	89405	1959	63397641
Knee arthroplasty	16.53	9.93	32	89390	54174	63345426
Adverse event	16.47	9.93	45	89377	67514	63332086
Serotonin syndrome	16.46	9.93	82	89340	28600	63371000
Device expulsion	16.38	9.93	15	89407	34907	63364693
Vitamin D increased	16.35	9.93	11	89411	701	63398899
Pruritus	16.34	9.93	386	89036	361067	63038533
Nail bed tenderness	16.32	9.93	9	89413	400	63399200
Drug resistance	16.20	9.93	6	89416	22927	63376673
Blood ethanol	16.19	9.93	5	89417	47	63399553
Alcoholic	16.19	9.93	5	89417	47	63399553
Arthritis bacterial	16.09	9.93	31	89391	6432	63393168
Axillary nerve injury	16.06	9.93	4	89418	15	63399585
Procedural complication	15.95	9.93	28	89394	5411	63394189
Pupil fixed	15.95	9.93	16	89406	1793	63397807
Sleep disorder	15.93	9.93	60	89362	81506	63318094
Phrenic nerve paralysis	15.91	9.93	7	89415	189	63399411
Ventricular extrasystoles	15.73	9.93	44	89378	11643	63387957
Congenital umbilical hernia	15.63	9.93	8	89414	305	63399295
Blood pressure decreased	15.61	9.93	150	89272	64872	63334728
Anorgasmia	15.51	9.93	10	89412	593	63399007
Administration site extravasation	15.50	9.93	12	89410	953	63398647
Osteonecrosis of jaw	15.42	9.93	16	89406	35107	63364493
Musculoskeletal stiffness	15.37	9.93	176	89246	184442	63215158
Blood pressure systolic increased	15.33	9.93	27	89395	47370	63352230
Blood ethanol increased	15.30	9.93	6	89416	120	63399480
Injection site abscess	15.23	9.93	13	89409	1185	63398415
Underdose	15.15	9.93	10	89412	27446	63372154
Trigeminal palsy	15.13	9.93	4	89418	20	63399580
Neonatal toxicity	15.13	9.93	4	89418	20	63399580
Incision site rash	15.13	9.93	4	89418	20	63399580
Anaphylactoid shock	15.07	9.93	8	89414	329	63399271
Vasoplegia syndrome	14.93	9.93	15	89407	1684	63397916
Cystitis	14.79	9.93	130	89292	54861	63344739
Brain death	14.79	9.93	21	89401	3389	63396211
Areflexia	14.71	9.93	20	89402	3098	63396502
Gait inability	14.69	9.93	33	89389	52926	63346674
Tooth infection	14.68	9.93	57	89365	17863	63381737
Vascular stenosis	14.58	9.93	8	89414	352	63399248
Viral infection	14.53	9.93	93	89329	35570	63364030
Multiple sclerosis relapse	14.46	9.93	29	89393	48449	63351151
Disease recurrence	14.43	9.93	11	89411	28019	63371581
Gastrointestinal haemorrhage	14.41	9.93	62	89360	81114	63318486
Transferrin decreased	14.39	9.93	7	89415	239	63399361
Anal sphincter atony	14.28	9.93	7	89415	243	63399357
Gastroenteritis	14.25	9.93	10	89412	26580	63373020
Therapeutic response decreased	14.25	9.93	42	89380	61483	63338117
Brain injury	14.25	9.93	31	89391	7012	63392588
Sensory loss	14.23	9.93	39	89383	10199	63389401
Tryptase increased	14.11	9.93	8	89414	375	63399225
Agranulocytosis	14.08	9.93	9	89413	25125	63374475
Opiates positive	14.06	9.93	8	89414	378	63399222
Gait disturbance	13.97	9.93	178	89244	183000	63216600
Emotional distress	13.96	9.93	86	89336	32463	63367137
Tracheal deviation	13.85	9.93	6	89416	156	63399444
Foetal exposure during delivery	13.77	9.93	6	89416	158	63399442
Hepatic encephalopathy	13.76	9.93	41	89381	11241	63388359
Dissociative amnesia	13.75	9.93	4	89418	30	63399570
Pulmonary embolism	13.71	9.93	102	89320	116582	63283018
Autonomic neuropathy	13.57	9.93	12	89410	1147	63398453
Blood pressure fluctuation	13.56	9.93	28	89394	46289	63353311
Gastrointestinal disorder	13.46	9.93	119	89303	131120	63268480
Retinal artery occlusion	13.44	9.93	14	89408	1639	63397961
Asphyxia	13.42	9.93	28	89394	6153	63393447
Product contamination	13.42	9.93	10	89412	750	63398850
Anaphylactoid reaction	13.38	9.93	21	89401	3702	63395898
Liquid product physical issue	13.37	9.93	12	89410	1170	63398430
Weight increased	13.35	9.93	273	89149	260519	63139081
Drug tolerance decreased	13.35	9.93	4	89418	17469	63382131
Hypocalcaemia	13.30	9.93	15	89407	31698	63367902
Nephrolithiasis	13.30	9.93	103	89319	41881	63357719
Spinal stroke	13.21	9.93	4	89418	35	63399565
Airway peak pressure increased	13.19	9.93	7	89415	288	63399312
Immunodeficiency	13.18	9.93	6	89416	20248	63379352
Left ventricle outflow tract obstruction	13.16	9.93	7	89415	289	63399311
Confusional state	13.15	9.93	244	89178	236136	63163464
Hospitalisation	13.09	9.93	180	89242	84901	63314699
Heliotrope rash	13.02	9.93	6	89416	181	63399419
Propionibacterium infection	13.01	9.93	4	89418	37	63399563
Rheumatoid nodule	12.97	9.93	4	89418	17151	63382449
Vascular resistance systemic decreased	12.89	9.93	5	89417	97	63399503
Hemiplegic migraine	12.89	9.93	5	89417	97	63399503
Drug hypersensitivity	12.89	9.93	336	89086	310351	63089249
Hallucination, tactile	12.88	9.93	7	89415	302	63399298
Infusion related reaction	12.87	9.93	256	89166	245265	63154335
Intercepted medication error	12.84	9.93	9	89413	613	63398987
Arthritis	12.84	9.93	103	89319	115818	63283782
Vaginal abscess	12.84	9.93	8	89414	447	63399153
Inappropriate antidiuretic hormone secretion	12.83	9.93	3	89419	15459	63384141
Gastric mucosa erythema	12.73	9.93	7	89415	309	63399291
Pneumocystis jirovecii pneumonia	12.69	9.93	4	89418	16910	63382690
Pupillary reflex impaired	12.62	9.93	15	89407	2032	63397568
Suicidal ideation	12.60	9.93	139	89283	62282	63337318
Myelosuppression	12.59	9.93	9	89413	23694	63375906
Liver function test abnormal	12.58	9.93	31	89391	48150	63351450
Amphetamines positive	12.58	9.93	6	89416	196	63399404
Application site alopecia	12.55	9.93	3	89419	9	63399591
Renal impairment	12.52	9.93	73	89349	88282	63311318
Renal tubular necrosis	12.49	9.93	41	89381	11837	63387763
Harlequin syndrome	12.39	9.93	4	89418	44	63399556
Pancreatitis acute	12.35	9.93	12	89410	27154	63372446
Infusion site warmth	12.35	9.93	14	89408	1804	63397796
Road traffic accident	12.24	9.93	91	89331	36541	63363059
Injection site discharge	12.18	9.93	10	89412	864	63398736
Liver disorder	12.18	9.93	37	89385	53650	63345950
Body dysmorphic disorder	12.18	9.93	7	89415	337	63399263
Therapy cessation	12.15	9.93	79	89343	30378	63369222
Product contamination microbial	12.12	9.93	6	89416	213	63399387
Paralysis	12.09	9.93	36	89386	9864	63389736
Disinhibition	12.09	9.93	10	89412	873	63398727
Intraocular pressure fluctuation	12.08	9.93	4	89418	48	63399552
Orbital infection	12.08	9.93	4	89418	48	63399552
Withdrawal syndrome	12.07	9.93	58	89364	19939	63379661
Implant site swelling	12.00	9.93	8	89414	502	63399098
Eye infection	11.95	9.93	41	89381	12104	63387496
Conjunctival oedema	11.87	9.93	9	89413	693	63398907
Poikiloderma	11.86	9.93	6	89416	223	63399377
Osteoarthritis	11.86	9.93	82	89340	95261	63304339
Implant site bruising	11.83	9.93	7	89415	356	63399244
Incision site swelling	11.81	9.93	6	89416	225	63399375
Product availability issue	11.81	9.93	21	89401	4100	63395500
Infusion site scar	11.80	9.93	8	89414	516	63399084
Infusion site streaking	11.79	9.93	8	89414	517	63399083
Hyperlipasaemia	11.74	9.93	9	89413	704	63398896
Concussion	11.66	9.93	34	89388	9210	63390390
Toxicologic test abnormal	11.65	9.93	9	89413	712	63398888
Platelet count decreased	11.60	9.93	106	89316	116016	63283584
Drug eruption	11.58	9.93	14	89408	28680	63370920
Night sweats	11.54	9.93	33	89389	48781	63350819
Migraine	11.47	9.93	207	89215	103139	63296461
Fear-related avoidance of activities	11.47	9.93	5	89417	132	63399468
Allergy to immunoglobulin therapy	11.45	9.93	4	89418	57	63399543
Product administration error	11.44	9.93	62	89360	22335	63377265
Delirium	11.36	9.93	115	89307	50426	63349174
Arthritis fungal	11.35	9.93	3	89419	15	63399585
Coccygectomy	11.35	9.93	3	89419	15	63399585
Balance disorder	11.31	9.93	71	89351	84351	63315249
Peritonitis	11.29	9.93	5	89417	17149	63382451
Poor venous access	11.28	9.93	46	89376	14739	63384861
Joint stiffness	11.27	9.93	99	89323	41770	63357830
Brachial artery entrapment syndrome	11.26	9.93	4	89418	60	63399540
Sinus disorder	11.25	9.93	66	89356	24487	63375113
Accelerated idioventricular rhythm	11.20	9.93	4	89418	61	63399539
Administration site erythema	11.18	9.93	9	89413	756	63398844
Premenstrual dysphoric disorder	11.14	9.93	4	89418	62	63399538
Inadequate analgesia	11.14	9.93	17	89405	2926	63396674
Quadriparesis	11.11	9.93	14	89408	2015	63397585
Cholestasis of pregnancy	11.10	9.93	11	89411	1214	63398386
Intentional self-injury	11.09	9.93	68	89354	25619	63373981
Paranasal cyst	11.09	9.93	7	89415	400	63399200
Bronchospasm	11.07	9.93	51	89371	17229	63382371
Procedural anxiety	11.07	9.93	9	89413	767	63398833
Spinal cord infarction	11.06	9.93	6	89416	258	63399342
Peripheral venous disease	11.02	9.93	4	89418	15473	63384127
Diplopia	11.01	9.93	64	89358	23664	63375936
Inability to afford medication	10.99	9.93	15	89407	2332	63397268
Cardiac death	10.96	9.93	8	89414	581	63399019
Spinal cord oedema	10.94	9.93	5	89417	148	63399452
Retinal cyst	10.69	9.93	4	89418	70	63399530
Bacterial infection	10.66	9.93	55	89367	19444	63380156
Localised infection	10.64	9.93	76	89346	30134	63369466
Blood calcium decreased	10.57	9.93	13	89409	26438	63373162
Anxiety	10.53	9.93	390	89032	217151	63182449
Metapneumovirus infection	10.51	9.93	10	89412	1050	63398550
Dysarthria	10.48	9.93	99	89323	42612	63356988
Immunisation reaction	10.48	9.93	8	89414	622	63398978
Spinal cord compression	10.46	9.93	20	89402	4128	63395472
Repetitive strain injury	10.41	9.93	5	89417	166	63399434
Bone erosion	10.40	9.93	6	89416	17711	63381889
Foetal heart rate abnormal	10.40	9.93	8	89414	629	63398971
Apnoeic attack	10.40	9.93	6	89416	291	63399309
Hepatocellular injury	10.38	9.93	14	89408	27367	63372233
Obstruction	10.37	9.93	17	89405	3110	63396490
Face oedema	10.36	9.93	56	89366	20156	63379444
Creatinine renal clearance decreased	10.35	9.93	5	89417	16303	63383297
Metabolic acidosis	10.34	9.93	103	89319	44966	63354634
Stevens-Johnson syndrome	10.25	9.93	12	89410	24938	63374662
Hypercalcaemia	10.22	9.93	15	89407	28307	63371293
Genital ulceration	10.20	9.93	8	89414	647	63398953
Wrong product administered	10.19	9.93	25	89397	6116	63393484
Orbital oedema	10.18	9.93	6	89416	303	63399297
Cranial nerve palsies multiple	10.14	9.93	3	89419	24	63399576
Hyperglycaemia	10.12	9.93	28	89394	41839	63357761
Bone marrow failure	10.10	9.93	16	89406	29274	63370326
Lethargy	10.09	9.93	122	89300	55885	63343715
Streptococcal infection	10.07	9.93	24	89398	5763	63393837
Gastrointestinal bacterial overgrowth	10.07	9.93	9	89413	873	63398727
Haemorrhagic vasculitis	10.07	9.93	4	89418	83	63399517
Lack of infusion site rotation	10.03	9.93	3	89419	25	63399575
Electrocardiogram ST segment depression	10.03	9.93	16	89406	2861	63396739
Birth mark	9.98	9.93	5	89417	182	63399418
Amnesia	9.98	9.93	121	89301	55464	63344136

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	3971.46	11.21	2305	56074	96791	34801761
Toxicity to various agents	2728.55	11.21	2414	55965	197948	34700604
Completed suicide	2579.49	11.21	1750	56629	96418	34802134
Cardio-respiratory arrest	582.19	11.21	581	57798	54692	34843860
Intentional overdose	506.36	11.21	484	57895	43190	34855362
Overdose	488.43	11.21	677	57702	90382	34808170
Alcohol abuse	408.09	11.21	185	58194	4505	34894047
Alcohol interaction	386.58	11.21	155	58224	2758	34895794
Intentional product misuse	347.14	11.21	404	57975	45207	34853345
Suspected suicide	270.03	11.21	140	58239	4608	34893944
Suicide attempt	257.54	11.21	322	58057	38794	34859758
Methaemoglobinaemia	248.98	11.21	121	58258	3460	34895092
Alcohol poisoning	239.61	11.21	118	58261	3475	34895077
Drug dependence	221.06	11.21	236	58143	23981	34874571
Substance abuse	220.31	11.21	145	58234	7496	34891056
Cardiac arrest	212.57	11.21	485	57894	95674	34802878
Respiratory depression	191.75	11.21	182	58197	16063	34882489
Coma	186.14	11.21	299	58080	45379	34853173
Respiratory arrest	181.57	11.21	229	58150	27814	34870738
Exposure to toxic agent	149.88	11.21	87	58292	3588	34894964
Asphyxia	137.28	11.21	104	58275	6731	34891821
Diarrhoea	122.89	11.21	296	58083	389616	34508936
Local anaesthetic systemic toxicity	117.24	11.21	36	58343	274	34898278
Alcohol use	116.26	11.21	71	58308	3217	34895335
Anaphylactic reaction	116.20	11.21	200	58179	32101	34866451
Anaesthetic complication	112.91	11.21	49	58330	1071	34897481
Poisoning deliberate	106.38	11.21	95	58284	7749	34890803
Aggression	102.47	11.21	211	58168	38753	34859799
Incorrect route of product administration	97.28	11.21	122	58257	14723	34883829
Death	96.96	11.21	1052	57327	396997	34501555
Tachycardia	95.44	11.21	335	58044	84437	34814115
Toxic anterior segment syndrome	95.04	11.21	44	58335	1125	34897427
Poisoning	92.38	11.21	108	58271	12118	34886434
Anaphylactic shock	91.95	11.21	123	58256	15818	34882734
Mydriasis	85.22	11.21	81	58298	7156	34891396
Blood alcohol increased	82.94	11.21	36	58343	787	34897765
Miosis	81.85	11.21	90	58289	9445	34889107
Anaemia	81.60	11.21	167	58212	233168	34665384
Injury	80.92	11.21	133	58246	20554	34877998
Hypotension	80.11	11.21	638	57741	221011	34677541
Drug use disorder	75.94	11.21	60	58319	4131	34894421
Substance use disorder	75.01	11.21	33	58346	746	34897806
Disease progression	74.55	11.21	44	58335	108033	34790519
Unresponsive to stimuli	74.49	11.21	151	58228	27418	34871134
Fear	65.32	11.21	84	58295	10392	34888160
Decreased appetite	63.44	11.21	113	58266	166279	34732273
Electrocardiogram ST segment elevation	62.39	11.21	59	58320	5179	34893373
Dyspnoea	62.28	11.21	372	58007	376410	34522142
Prescription drug used without a prescription	59.96	11.21	40	58339	2114	34896438
General physical health deterioration	58.59	11.21	77	58302	128192	34770360
Fatigue	58.10	11.21	372	58007	370281	34528271
Depressed level of consciousness	56.80	11.21	179	58200	42662	34855890
Weight decreased	56.76	11.21	132	58247	176169	34722383
Sinusitis	53.98	11.21	172	58207	41230	34857322
Renal injury	53.58	11.21	79	58300	11116	34887436
Intentional product use issue	52.92	11.21	219	58160	59597	34838955
Interstitial lung disease	51.88	11.21	22	58357	65260	34833292
Generalised tonic-clonic seizure	51.39	11.21	111	58268	21063	34877489
Anhedonia	50.75	11.21	63	58316	7522	34891030
Off label use	50.17	11.21	454	57925	419070	34479482
Emotional distress	50.08	11.21	90	58289	14936	34883616
Ventricular tachycardia	48.86	11.21	125	58254	26454	34872098
Agitation	48.32	11.21	207	58172	57192	34841360
Asthenia	47.13	11.21	230	58149	245021	34653531
Drug withdrawal syndrome	47.02	11.21	103	58276	19731	34878821
Electrocardiogram QRS complex prolonged	46.95	11.21	49	58330	4845	34893707
Rash	46.90	11.21	202	58177	222550	34676002
Loss of consciousness	46.65	11.21	266	58113	82401	34816151
Medication error	44.70	11.21	118	58261	25447	34873105
Accidental death	44.15	11.21	35	58344	2421	34896131
White blood cell count decreased	43.87	11.21	57	58322	95388	34803164
Haemoglobin decreased	43.36	11.21	85	58294	120687	34777865
Bradycardia	42.76	11.21	243	58136	75175	34823377
Accidental overdose	42.63	11.21	100	58279	20040	34878512
Alcohol withdrawal syndrome	42.34	11.21	28	58351	1458	34897094
Accident	42.21	11.21	47	58332	5000	34893552
Arthralgia	41.68	11.21	145	58234	169896	34728656
Brain oedema	41.31	11.21	79	58300	13742	34884810
Myocardial infarction	41.11	11.21	88	58291	120997	34777555
Acute kidney injury	40.45	11.21	321	58058	304667	34593885
Behaviour disorder	39.83	11.21	45	58334	4865	34893687
Pulmonary oedema	39.69	11.21	171	58208	47358	34851194
Infusion site pain	39.55	11.21	40	58339	3811	34894741
Cardiac failure congestive	39.02	11.21	49	58330	83221	34815331
Drug screen positive	38.76	11.21	40	58339	3903	34894649
Ventricular fibrillation	38.17	11.21	104	58275	22850	34875702
Suicidal ideation	37.40	11.21	150	58229	40238	34858314
Alcohol intolerance	36.92	11.21	17	58362	429	34898123
Oedema peripheral	36.71	11.21	92	58287	119720	34778832
Metabolic acidosis	35.59	11.21	156	58223	43524	34855028
Pyrexia	35.25	11.21	371	58008	332642	34565910
Anaesthetic complication neurological	34.72	11.21	15	58364	324	34898228
Ex-drug abuser	34.37	11.21	12	58367	142	34898410
Condition aggravated	34.20	11.21	185	58194	192011	34706541
Malignant neoplasm progression	33.32	11.21	60	58319	87986	34810566
Dehydration	33.07	11.21	109	58270	129860	34768692
Neutropenia	33.07	11.21	142	58237	156636	34741916
Platelet count decreased	32.87	11.21	97	58282	119620	34778932
Alcoholism	32.67	11.21	32	58347	2933	34895619
Infusion site extravasation	32.19	11.21	38	58341	4306	34894246
Road traffic accident	32.00	11.21	82	58297	17368	34881184
Rheumatoid arthritis	31.82	11.21	12	58367	38226	34860326
Pain in extremity	30.23	11.21	109	58270	126404	34772148
Drug intolerance	30.11	11.21	33	58346	59537	34839015
Oculocardiac reflex	30.08	11.21	9	58370	62	34898490
Intentional self-injury	29.83	11.21	69	58310	13702	34884850
Leukopenia	29.43	11.21	37	58342	62819	34835733
Cough	29.26	11.21	140	58239	150000	34748552
Infusion site swelling	29.24	11.21	28	58351	2496	34896056
Sinus tachycardia	29.21	11.21	79	58300	17281	34881271
Anal inflammation	28.83	11.21	21	58358	1279	34897273
Myalgia	28.64	11.21	61	58318	84049	34814503
Drug abuser	28.33	11.21	34	58345	3920	34894632
Cardiac failure	27.99	11.21	70	58309	91178	34807374
Haematochezia	27.98	11.21	22	58357	46512	34852040
Cytomegalovirus infection	27.83	11.21	5	58374	26130	34872422
Abdominal pain	27.73	11.21	160	58219	163458	34735094
Respiratory acidosis	27.65	11.21	38	58341	5012	34893540
Thrombocytopenia	27.44	11.21	151	58228	156096	34742456
Homicide	27.33	11.21	18	58361	931	34897621
Malaise	27.24	11.21	190	58189	185635	34712917
Opiates positive	27.05	11.21	15	58364	566	34897986
Pancytopenia	26.91	11.21	76	58303	95081	34803471
Loss of personal independence in daily activities	26.64	11.21	11	58368	33168	34865384
Agranulocytosis	26.60	11.21	4	58375	23817	34874735
Hypoxia	26.43	11.21	170	58209	54925	34843627
Ear infection	26.40	11.21	55	58324	10176	34888376
Infusion site bruising	26.05	11.21	16	58363	732	34897820
Nausea	25.47	11.21	407	57972	339501	34559051
Psoriasis	25.09	11.21	17	58362	38795	34859757
Shock	24.99	11.21	93	58286	24086	34874466
Hyperthermia malignant	24.93	11.21	24	58355	2153	34896399
Drug reaction with eosinophilia and systemic symptoms	24.85	11.21	12	58367	33000	34865552
Therapeutic product effect incomplete	24.45	11.21	29	58350	50512	34848040
Conjunctival scar	24.15	11.21	9	58370	130	34898422
Dyspnoea exertional	24.13	11.21	22	58357	43257	34855295
Infusion site erythema	24.06	11.21	24	58355	2249	34896303
Foetal alcohol syndrome	23.78	11.21	9	58370	136	34898416
Therapy interrupted	23.72	11.21	63	58316	13634	34884918
Pneumonia	23.70	11.21	445	57934	362182	34536370
Myocardial fibrosis	23.56	11.21	18	58361	1179	34897373
Prostate cancer	23.51	11.21	19	58360	39630	34858922
Spinal cord infarction	23.38	11.21	11	58368	292	34898260
Abdominal discomfort	23.34	11.21	40	58339	59795	34838757
Amnesia	23.27	11.21	97	58282	26466	34872086
Neuropathy peripheral	23.18	11.21	67	58312	83196	34815356
Weight increased	22.99	11.21	79	58300	92954	34805598
Impaired driving ability	22.85	11.21	25	58354	2608	34895944
Angina pectoris	22.71	11.21	12	58367	31351	34867201
Embolia cutis medicamentosa	22.61	11.21	10	58369	229	34898323
Blood pressure fluctuation	22.61	11.21	7	58372	25242	34873310
Blood creatinine increased	22.56	11.21	82	58297	94894	34803658
Somnolence	22.51	11.21	284	58095	110832	34787720
Tubulointerstitial nephritis	22.43	11.21	4	58375	21020	34877532
Withdrawal syndrome	22.29	11.21	58	58321	12397	34886155
Sensorimotor disorder	22.20	11.21	12	58367	430	34898122
Melaena	22.20	11.21	16	58363	35364	34863188
Chemical burn	22.14	11.21	10	58369	241	34898311
Brain stem syndrome	22.04	11.21	13	58366	552	34898000
Coronary artery disease	22.02	11.21	29	58350	48276	34850276
Unevaluable event	21.85	11.21	110	58269	32480	34866072
Corneal oedema	21.64	11.21	18	58361	1333	34897219
SARS-CoV-2 test negative	21.54	11.21	16	58363	1004	34897548
Diabetes mellitus	21.52	11.21	28	58351	46845	34851707
Blood pressure systolic increased	21.21	11.21	6	58373	22946	34875606
Blood ethanol	21.19	11.21	8	58371	120	34898432
Apnoea	21.04	11.21	39	58340	6625	34891927
Circulatory collapse	20.98	11.21	80	58299	20958	34877594
Dysarthria	20.98	11.21	114	58265	34668	34863884
Postmortem blood drug level	20.94	11.21	9	58370	192	34898360
Pupil fixed	20.90	11.21	20	58359	1781	34896771
Haematuria	20.90	11.21	32	58347	50034	34848518
Pruritus	20.87	11.21	145	58234	141836	34756716
Removal of foreign body	20.49	11.21	6	58373	38	34898514
Drug resistance	20.17	11.21	9	58370	25918	34872634
Deep vein thrombosis	20.05	11.21	50	58329	65198	34833354
Seizure	19.97	11.21	265	58114	104592	34793960
Aqueous fibrin	19.73	11.21	6	58373	44	34898508
Somnambulism	19.73	11.21	25	58354	3047	34895505
Acute pulmonary oedema	19.56	11.21	40	58339	7303	34891249
Tryptase increased	19.51	11.21	9	58370	228	34898324
Transient ischaemic attack	19.36	11.21	11	58368	27602	34870950
Intracranial hypotension	19.26	11.21	9	58370	235	34898317
Respiratory tract infection bacterial	19.20	11.21	19	58360	1763	34896789
Lagophthalmos	19.18	11.21	7	58372	95	34898457
Disease recurrence	19.17	11.21	6	58373	21484	34877068
Septic shock	19.13	11.21	59	58320	71775	34826777
Insurance issue	18.82	11.21	20	58359	2019	34896533
Endophthalmitis	18.61	11.21	26	58353	3482	34895070
Pneumocystis jirovecii pneumonia	18.50	11.21	5	58374	19705	34878847
Musculoskeletal stiffness	18.39	11.21	31	58348	46649	34851903
Dextrocardia	17.96	11.21	7	58372	115	34898437
Hepatic function abnormal	17.90	11.21	29	58350	44334	34854218
Physical assault	17.81	11.21	15	58364	1130	34897422
Bezoar	17.67	11.21	15	58364	1142	34897410
Reperfusion arrhythmia	17.58	11.21	6	58373	66	34898486
Spinal operation	17.41	11.21	23	58356	2921	34895631
Bone marrow failure	17.37	11.21	14	58365	29239	34869313
Stress	17.32	11.21	98	58281	30249	34868303
Renal impairment	17.32	11.21	90	58289	94423	34804129
Respiratory paralysis	17.19	11.21	6	58373	71	34898481
Hepatic fibrosis	17.18	11.21	29	58350	4578	34893974
Restlessness	17.08	11.21	86	58293	25396	34873156
Liver disorder	16.98	11.21	18	58361	32979	34865573
Constipation	16.81	11.21	147	58232	136835	34761717
Dyspepsia	16.80	11.21	22	58357	36710	34861842
Anxiety	16.80	11.21	246	58133	99182	34799370
Catecholamine crisis	16.77	11.21	5	58374	34	34898518
Pulmonary fibrosis	16.65	11.21	5	58374	18391	34880161
Product prescribing error	16.27	11.21	9	58370	22918	34875634
Bronchospasm	16.24	11.21	47	58332	10684	34887868
Asthma	16.19	11.21	29	58350	42627	34855925
Diabetic ketoacidosis	16.14	11.21	5	58374	18027	34880525
Anal sphincter atony	15.83	11.21	6	58373	91	34898461
Substance-induced mood disorder	15.83	11.21	6	58373	91	34898461
Drug level increased	15.82	11.21	76	58303	22020	34876532
Accidental poisoning	15.81	11.21	12	58367	778	34897774
Respiratory tract infection	15.74	11.21	70	58309	19642	34878910
Injection site ulcer	15.69	11.21	8	58371	254	34898298
Vitreous disorder	15.60	11.21	6	58373	95	34898457
Dizziness	15.55	11.21	264	58115	218257	34680295
Neuromuscular blockade	15.52	11.21	8	58371	260	34898292
Respiratory tract infection viral	15.40	11.21	20	58359	2497	34896055
Muscular weakness	15.36	11.21	66	58313	72831	34825721
Wrong product administered	15.34	11.21	30	58349	5304	34893248
Visceral oedema	15.32	11.21	6	58373	100	34898452
Product adhesion issue	15.31	11.21	16	58363	1584	34896968
Infusion site haemorrhage	15.30	11.21	13	58366	991	34897561
Electrocardiogram T wave amplitude increased	15.26	11.21	5	58374	48	34898504
Trigemino-cardiac reflex	14.87	11.21	7	58372	186	34898366
Gastrointestinal disorder	14.85	11.21	21	58358	33927	34864625
Red blood cell count decreased	14.82	11.21	16	58363	29074	34869478
Toxicologic test abnormal	14.70	11.21	10	58369	546	34898006
Jaundice	14.68	11.21	19	58360	31863	34866689
Tracheitis	14.63	11.21	11	58368	703	34897849
Feeling drunk	14.54	11.21	17	58362	1906	34896646
Sopor	14.53	11.21	49	58330	12087	34886465
Myelosuppression	14.50	11.21	7	58372	19258	34879294
Phaeochromocytoma crisis	14.41	11.21	5	58374	58	34898494
Pulseless electrical activity	14.39	11.21	35	58344	7176	34891376
Suicidal behaviour	14.38	11.21	15	58364	1482	34897070
Hypercalcaemia	14.38	11.21	4	58375	15464	34883088
Neutrophil count decreased	14.30	11.21	41	58338	51063	34847489
Gastrointestinal haemorrhage	14.18	11.21	88	58291	88389	34810163
Alopecia	14.03	11.21	12	58367	24343	34874209
Joint swelling	14.02	11.21	52	58327	59838	34838714
Neoplasm progression	14.02	11.21	11	58368	23289	34875263
Gun shot wound	14.00	11.21	13	58366	1115	34897437
Amphetamines positive	13.97	11.21	7	58372	214	34898338
Myoclonus	13.87	11.21	55	58324	14670	34883882
Mobility decreased	13.82	11.21	18	58361	30110	34868442
Psychiatric disorder prophylaxis	13.69	11.21	5	58374	68	34898484
Hypoxic-ischaemic encephalopathy	13.66	11.21	26	58353	4506	34894046
Behavioural addiction	13.63	11.21	5	58374	69	34898483
Sepsis	13.60	11.21	196	58183	166365	34732187
Pulse absent	13.59	11.21	30	58349	5773	34892779
Delirium tremens	13.57	11.21	10	58369	620	34897932
Product preparation error	13.54	11.21	18	58361	2299	34896253
Delayed recovery from anaesthesia	13.52	11.21	11	58368	790	34897762
Hyperkalaemia	13.32	11.21	65	58314	69324	34829228
International normalised ratio increased	13.22	11.21	38	58341	47289	34851263
Brachial plexus injury	13.19	11.21	5	58374	76	34898476
Retinal artery occlusion	13.16	11.21	16	58363	1869	34896683
Arthritis	13.11	11.21	20	58359	31326	34867226
Accidental exposure to product	13.03	11.21	49	58330	12753	34885799
Ventricular tachyarrhythmia	13.03	11.21	8	58371	366	34898186
Incorrect drug administration rate	12.77	11.21	15	58364	1690	34896862
Eosinophilia	12.73	11.21	15	58364	26207	34872345
Drug diversion	12.62	11.21	11	58368	868	34897684
Myokymia	12.57	11.21	5	58374	87	34898465
Pulmonary embolism	12.52	11.21	93	58286	89653	34808899
Product administration error	12.27	11.21	57	58322	16287	34882265
Proteinuria	12.27	11.21	8	58371	18634	34879918
Peritonitis	12.24	11.21	6	58373	16359	34882193
Haemoptysis	12.23	11.21	25	58354	34981	34863571
Cluster headache	12.23	11.21	9	58370	557	34897995
Bradypnoea	12.17	11.21	19	58360	2810	34895742
Retinal vasculitis	12.07	11.21	8	58371	418	34898134
Procedural hypotension	12.03	11.21	11	58368	925	34897627
Administration related reaction	12.02	11.21	5	58374	98	34898454
Underdose	12.02	11.21	4	58375	13776	34884776
Dysgeusia	11.98	11.21	16	58363	26481	34872071
Cauda equina syndrome	11.95	11.21	9	58370	577	34897975
Corneal opacity	11.95	11.21	9	58370	577	34897975
Postmortem blood drug level abnormal	11.94	11.21	7	58372	294	34898258
Cardiotoxicity	11.90	11.21	28	58351	5620	34892932
Haemodynamic instability	11.89	11.21	39	58340	9484	34889068
Seizure like phenomena	11.87	11.21	10	58369	754	34897798
Administration site pain	11.83	11.21	7	58372	299	34898253
Acute myocardial infarction	11.71	11.21	48	58331	53671	34844881
Alcoholic liver disease	11.65	11.21	9	58370	599	34897953
Injection site extravasation	11.61	11.21	19	58360	2923	34895629
Chronic kidney disease	11.58	11.21	33	58346	41177	34857375
Febrile neutropenia	11.54	11.21	160	58219	136689	34761863
Colitis	11.53	11.21	29	58350	37721	34860831
Phlebitis superficial	11.48	11.21	7	58372	316	34898236
Arthropathy	11.42	11.21	17	58362	26890	34871662
Blood glucose increased	11.41	11.21	65	58314	66653	34831899
Benzodiazepine drug level therapeutic	11.41	11.21	4	58375	48	34898504
Alcoholic pancreatitis	11.39	11.21	6	58373	204	34898348
Electrocardiogram repolarisation abnormality	11.37	11.21	11	58368	993	34897559
Vitreous floaters	11.34	11.21	21	58358	3564	34894988
Drug interaction	11.29	11.21	473	57906	225473	34673079
Patient uncooperative	11.28	11.21	8	58371	467	34898085

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	5901.05	9.83	3968	115099	241799	79383522
Drug abuse	4976.63	9.83	3063	116004	159628	79465693
Toxicity to various agents	4850.20	9.83	4402	114665	417138	79208183
Cardio-respiratory arrest	1343.34	9.83	1187	117880	107323	79517998
Intentional overdose	886.90	9.83	935	118132	105025	79520296
Overdose	790.78	9.83	1162	117905	183044	79442277
Cardiac arrest	618.13	9.83	1000	118067	171096	79454225
Alcohol interaction	610.01	9.83	241	118826	4633	79620688
Local anaesthetic systemic toxicity	512.54	9.83	145	118922	909	79624412
Suspected suicide	489.98	9.83	262	118805	10314	79615007
Intentional product misuse	466.33	9.83	640	118427	94525	79530796
Alcohol abuse	385.28	9.83	179	118888	5184	79620137
Death	375.28	9.83	1755	117312	564759	79060562
Respiratory arrest	374.95	9.83	446	118621	57104	79568217
Methaemoglobinaemia	370.02	9.83	176	118891	5381	79619940
Alcohol poisoning	355.97	9.83	164	118903	4657	79620664
Suicide attempt	329.31	9.83	505	118562	82427	79542894
Toxic anterior segment syndrome	308.95	9.83	126	118941	2638	79622683
Exposure to toxic agent	297.74	9.83	180	118887	8978	79616343
Coma	232.83	9.83	484	118583	100165	79525156
Drug dependence	220.69	9.83	288	118779	40481	79584840
Anaphylactic reaction	220.39	9.83	425	118642	83318	79542003
Substance abuse	215.55	9.83	155	118912	10371	79614950
Alcohol use	210.70	9.83	115	118952	4716	79620605
Anaesthetic complication	210.27	9.83	97	118970	2762	79622559
Diarrhoea	183.47	9.83	687	118380	879802	78745519
Respiratory depression	182.97	9.83	216	118851	27414	79597907
Anaphylactic shock	177.53	9.83	243	118824	35753	79589568
Synovitis	169.62	9.83	15	119052	150719	79474602
General physical health deterioration	148.60	9.83	116	118951	275122	79350199
Poisoning deliberate	148.16	9.83	161	118906	18667	79606654
Mydriasis	147.88	9.83	156	118911	17487	79607834
Arthralgia	146.83	9.83	406	118661	571397	79053924
Incorrect route of product administration	143.22	9.83	216	118851	34713	79590608
Hypotension	135.54	9.83	1121	117946	439196	79186125
Drug intolerance	134.30	9.83	118	118949	264001	79361320
Joint swelling	133.92	9.83	140	118927	288506	79336815
Generalised tonic-clonic seizure	125.60	9.83	231	118836	43679	79581642
Tachycardia	125.39	9.83	562	118505	177206	79448115
Unresponsive to stimuli	123.97	9.83	264	118803	55524	79569797
Asphyxia	122.84	9.83	117	118950	11603	79613718
Blood alcohol increased	121.12	9.83	52	119015	1243	79624078
Hand deformity	120.63	9.83	9	119058	103910	79521411
Abdominal discomfort	120.40	9.83	118	118949	250609	79374712
Poisoning	114.77	9.83	164	118903	25108	79600213
Pemphigus	114.53	9.83	9	119058	99573	79525748
Kounis syndrome	113.62	9.83	74	118993	4208	79621113
Anti-cyclic citrullinated peptide antibody positive	110.04	9.83	3	119064	83140	79542181
Agitation	108.70	9.83	362	118705	99353	79525968
Pericarditis	108.00	9.83	14	119053	104222	79521099
Maternal exposure during delivery	106.33	9.83	48	119019	1298	79624023
Miosis	103.81	9.83	123	118944	15666	79609655
Aggression	102.84	9.83	232	118835	50726	79574595
Systemic lupus erythematosus	102.63	9.83	27	119040	121122	79504199
Glossodynia	102.11	9.83	16	119051	103321	79522000
Rash	101.70	9.83	481	118586	577877	79047444
Therapy interrupted	101.37	9.83	174	118893	31167	79594154
Alopecia	99.84	9.83	119	118948	231236	79394085
Drug use disorder	99.60	9.83	91	118976	8560	79616761
Loss of consciousness	99.57	9.83	505	118562	167438	79457883
Hepatic enzyme increased	98.46	9.83	77	118990	182533	79442788
Substance use disorder	95.49	9.83	40	119027	898	79624423
Seizure	95.11	9.83	543	118524	188291	79437030
Fear	91.61	9.83	137	118930	21849	79603472
Fatigue	91.48	9.83	918	118149	928809	78696512
Electrocardiogram ST segment elevation	90.24	9.83	85	118982	8312	79617009
Bradycardia	89.94	9.83	421	118646	135136	79490185
Electrocardiogram QRS complex prolonged	89.39	9.83	95	118972	10738	79614583
Disease progression	85.93	9.83	89	118978	184273	79441048
Ventricular tachycardia	85.82	9.83	192	118875	41743	79583578
Asthenia	85.60	9.83	433	118634	511256	79114065
Renal injury	84.55	9.83	115	118952	16812	79608509
Pulseless electrical activity	82.86	9.83	104	118963	14056	79611265
Off label use	82.22	9.83	913	118154	906302	78719019
Anaesthetic complication neurological	81.12	9.83	32	119035	612	79624709
Helicobacter infection	81.00	9.83	6	119061	69698	79555623
Dyspnoea	79.83	9.83	857	118210	856168	78769153
Duodenal ulcer perforation	78.98	9.83	5	119062	66206	79559115
Therapeutic product effect decreased	78.77	9.83	77	118990	163786	79461535
Rheumatoid arthritis	78.00	9.83	119	118948	208351	79416970
Contraindicated product administered	75.75	9.83	74	118993	157464	79467857
Pulmonary oedema	75.43	9.83	296	118771	87958	79537363
Rheumatoid factor positive	72.95	9.83	4	119063	59835	79565486
Arthropathy	72.31	9.83	95	118972	177016	79448305
Sinus tachycardia	72.21	9.83	166	118901	36742	79588579
Anaemia	71.89	9.83	381	118686	444634	79180687
Mobility decreased	71.76	9.83	47	119020	122128	79503193
Corneal oedema	71.29	9.83	46	119021	2574	79622747
Ventricular fibrillation	70.82	9.83	151	118916	31775	79593546
Anhedonia	69.59	9.83	98	118969	14800	79610521
Depressed level of consciousness	67.66	9.83	305	118762	96347	79528974
Decreased appetite	64.12	9.83	278	118789	342140	79283181
Postmortem blood drug level abnormal	63.61	9.83	27	119040	627	79624694
Infusion site pruritus	63.05	9.83	51	119016	4067	79621254
Acute kidney injury	62.76	9.83	486	118581	518918	79106403
Unevaluable event	61.63	9.83	203	118864	55382	79569939
Accidental death	59.15	9.83	50	119017	4241	79621080
Wound	58.88	9.83	52	119015	116127	79509194
Infusion site pain	58.58	9.83	88	118979	14088	79611233
Folliculitis	58.43	9.83	7	119060	55373	79569948
Infusion site swelling	58.24	9.83	65	119002	7761	79617560
Swelling	57.61	9.83	151	118916	216560	79408761
Neutropenia	57.32	9.83	228	118839	287482	79337839
Alcoholism	56.78	9.83	46	119021	3677	79621644
Accidental overdose	56.52	9.83	158	118909	39423	79585898
Procedural hypotension	56.24	9.83	36	119031	1987	79623334
Infusion site erythema	56.18	9.83	70	118997	9390	79615931
Lagophthalmos	55.76	9.83	22	119045	421	79624900
Extradural abscess	55.11	9.83	32	119035	1480	79623841
Condition aggravated	54.56	9.83	482	118585	500642	79124679
Apnoea	53.21	9.83	76	118991	11628	79613693
Somnolence	53.06	9.83	568	118499	238413	79386908
Weight decreased	53.02	9.83	312	118755	354886	79270435
Interstitial lung disease	52.85	9.83	54	119013	112546	79512775
Infusion site extravasation	52.51	9.83	70	118997	10038	79615283
Insurance issue	52.20	9.83	53	119014	5680	79619641
Product adhesion issue	51.24	9.83	38	119029	2666	79622655
Pulse absent	51.01	9.83	69	118998	10034	79615287
Emotional distress	50.76	9.83	153	118914	39816	79585505
Shock	50.04	9.83	161	118906	43387	79581934
Psoriatic arthropathy	50.03	9.83	27	119040	77972	79547349
Incorrect drug administration rate	49.60	9.83	44	119023	3982	79621339
Drug reaction with eosinophilia and systemic symptoms	49.53	9.83	17	119050	64227	79561094
Abdominal pain upper	49.40	9.83	170	118897	223649	79401672
Prescription drug used without a prescription	49.05	9.83	44	119023	4041	79621280
Endophthalmitis	48.89	9.83	54	119013	6374	79618947
Impaired healing	48.45	9.83	36	119031	87619	79537702
Infusion site bruising	48.27	9.83	38	119029	2914	79622407
Embolia cutis medicamentosa	48.09	9.83	22	119045	614	79624707
Behaviour disorder	47.96	9.83	53	119014	6260	79619061
Hypoxia	47.49	9.83	290	118777	102953	79522368
Metabolic acidosis	47.35	9.83	246	118821	82283	79543038
Muscle injury	46.89	9.83	8	119059	48553	79576768
Infusion related reaction	46.77	9.83	181	118886	230056	79395265
Body tinea	46.66	9.83	31	119036	1823	79623498
Infusion site haemorrhage	46.52	9.83	41	119026	3679	79621642
Musculoskeletal stiffness	46.46	9.83	122	118945	174886	79450435
Cardiac failure congestive	46.18	9.83	89	118978	142313	79483008
Stress cardiomyopathy	45.69	9.83	69	118998	11097	79614224
Respiratory acidosis	45.53	9.83	69	118998	11131	79614190
Peripheral swelling	45.07	9.83	228	118839	269389	79355932
Abdominal pain	44.93	9.83	369	118698	389200	79236121
Extradural haematoma	44.84	9.83	36	119031	2840	79622481
Hypopyon	43.84	9.83	25	119042	1117	79624204
Pancytopenia	43.65	9.83	116	118951	165629	79459692
Chemical submission	43.35	9.83	17	119050	320	79625001
Nausea	43.28	9.83	1094	117973	956102	78669219
Pyrexia	42.97	9.83	734	118333	677975	78947346
Drug level increased	42.34	9.83	143	118924	39508	79585813
White blood cell count decreased	42.23	9.83	142	118925	188146	79437175
Sinusitis	42.15	9.83	462	118605	195039	79430282
Loss of personal independence in daily activities	41.87	9.83	55	119012	102525	79522796
Thrombocytopenia	41.72	9.83	229	118838	265030	79360291
Cough	41.57	9.83	349	118718	366440	79258881
Malignant neoplasm progression	41.53	9.83	88	118979	135902	79489419
Opiates positive	41.31	9.83	23	119044	981	79624340
Haematochezia	41.16	9.83	42	119025	87603	79537718
Aqueous fibrin	41.09	9.83	13	119054	125	79625196
Injury	41.06	9.83	226	118841	77270	79548051
Lower respiratory tract infection	40.83	9.83	82	118985	129138	79496183
Homicide	40.33	9.83	24	119043	1162	79624159
Drug hypersensitivity	40.24	9.83	271	118796	298645	79326676
Nystagmus	40.24	9.83	61	119006	9843	79615478
Retinal vasculitis	39.92	9.83	25	119042	1328	79623993
Pruritus	39.72	9.83	387	118680	394261	79231060
Postmortem blood drug level	39.36	9.83	16	119051	332	79624989
Cauda equina syndrome	39.08	9.83	25	119042	1378	79623943
Malaise	38.83	9.83	507	118560	489362	79135959
Haemoglobin decreased	38.75	9.83	185	118882	221934	79403387
Leukopenia	38.49	9.83	72	118995	116441	79508880
COVID-19	38.42	9.83	382	118685	157292	79468029
Agranulocytosis	38.19	9.83	10	119057	45020	79580301
Weight increased	38.08	9.83	250	118817	277136	79348185
Vitritis	38.07	9.83	27	119040	1767	79623554
Drug ineffective	37.92	9.83	1279	117788	1079634	78545687
Blood pressure fluctuation	37.86	9.83	27	119040	67118	79558203
Drug screen positive	37.84	9.83	46	119021	6017	79619304
Alcohol withdrawal syndrome	37.52	9.83	28	119039	1983	79623338
Blood ethanol	37.35	9.83	13	119054	172	79625149
C-reactive protein increased	37.34	9.83	86	118981	128941	79496380
Brain oedema	37.20	9.83	102	118965	25161	79600160
Anterior chamber cell	37.04	9.83	21	119046	928	79624393
Circulatory collapse	36.88	9.83	132	118935	37536	79587785
Pain in extremity	36.88	9.83	357	118710	364181	79261140
Type 2 diabetes mellitus	36.30	9.83	20	119047	57102	79568219
Myelosuppression	36.04	9.83	8	119059	40288	79585033
Seasonal allergy	35.70	9.83	77	118990	16329	79608992
Mental status changes	35.29	9.83	195	118872	66764	79558557
Drug abuser	34.92	9.83	44	119023	5969	79619352
Fear of eating	34.63	9.83	16	119051	457	79624864
Drug interaction	34.42	9.83	837	118230	414346	79210975
Oedema peripheral	34.31	9.83	228	118839	252060	79373261
Removal of foreign body	34.15	9.83	10	119057	72	79625249
Infusion site mass	33.86	9.83	24	119043	1569	79623752
Intentional self-injury	33.81	9.83	116	118951	32303	79593018
Nasopharyngitis	33.75	9.83	231	118836	253650	79371671
Spinal cord infarction	33.33	9.83	17	119050	606	79624715
Hypersensitivity	33.20	9.83	242	118825	261997	79363324
Surgery	33.09	9.83	116	118951	32650	79592671
Victim of sexual abuse	32.84	9.83	16	119051	516	79624805
Trigemino-cardiac reflex	32.61	9.83	13	119054	256	79625065
Accident	32.54	9.83	52	119015	8779	79616542
Septic shock	32.29	9.83	86	118981	122715	79502606
Blister	31.92	9.83	83	118984	119393	79505928
Gastrointestinal disorder	31.81	9.83	86	118981	122119	79503202
Pulmonary fibrosis	31.78	9.83	13	119054	44099	79581222
Blood pressure systolic increased	31.57	9.83	32	119035	66954	79558367
Liver disorder	31.47	9.83	37	119030	72380	79552941
Drug resistance	31.14	9.83	12	119055	42201	79583120
Oculocardiac reflex	31.08	9.83	9	119058	62	79625259
Psoriasis	30.81	9.83	54	119013	89533	79535788
Withdrawal syndrome	30.59	9.83	99	118968	26755	79598566
Ophthalmoplegia	30.38	9.83	29	119038	2883	79622438
Drug withdrawal syndrome	30.10	9.83	117	118950	34601	79590720
Purtscher retinopathy	29.92	9.83	10	119057	116	79625205
Cardiogenic shock	29.87	9.83	133	118934	41781	79583540
Orthostatic hypotension	29.85	9.83	24	119043	56140	79569181
Tryptase increased	29.74	9.83	16	119051	637	79624684
Anal sphincter atony	29.74	9.83	13	119054	325	79624996
Amphetamines positive	29.59	9.83	13	119054	329	79624992
Retinal artery occlusion	29.17	9.83	30	119037	3264	79622057
Anal inflammation	29.14	9.83	21	119046	1409	79623912
Rheumatic fever	29.14	9.83	4	119063	28521	79596800
Arthritis	29.04	9.83	82	118985	114798	79510523
Myocardial infarction	28.91	9.83	159	118908	183970	79441351
Underdose	28.81	9.83	7	119060	33144	79592177
Hyponatraemia	28.80	9.83	152	118915	177696	79447625
Disease recurrence	28.68	9.83	15	119052	44094	79581227
Infusion site urticaria	28.63	9.83	19	119048	1115	79624206
Hyperthermia malignant	28.46	9.83	28	119039	2889	79622432
Corneal epithelium defect	28.30	9.83	16	119051	703	79624618
Prescribed underdose	28.19	9.83	5	119062	29509	79595812
Conjunctival scar	28.10	9.83	11	119056	206	79625115
Systemic toxicity	28.08	9.83	10	119057	142	79625179
Platelet count decreased	27.95	9.83	173	118894	194491	79430830
Cyanosis	27.93	9.83	92	118975	25090	79600231
Infection susceptibility increased	27.85	9.83	31	119036	3690	79621631
Myocardial fibrosis	27.85	9.83	22	119045	1696	79623625
Bronchospasm	27.74	9.83	91	118976	24768	79600553
Stomatitis	27.52	9.83	119	118948	146638	79478683
Gastrointestinal toxicity	27.51	9.83	46	119021	8063	79617258
Blood cholesterol increased	27.42	9.83	52	119015	83668	79541653
Therapy cessation	27.38	9.83	120	118947	37442	79587879
Product administration error	27.35	9.83	107	118960	31739	79593582
Ill-defined disorder	27.21	9.83	35	119032	65840	79559481
Pupil fixed	27.19	9.83	30	119037	3536	79621785
Blood creatinine increased	27.12	9.83	129	118938	154928	79470393
Osteoarthritis	27.07	9.83	56	119011	87253	79538068
Suicidal ideation	27.03	9.83	201	118866	76139	79549182
Cytomegalovirus infection	27.00	9.83	15	119052	42629	79582692
Adverse event	26.99	9.83	30	119037	60184	79565137
Illness	26.92	9.83	139	118928	46372	79578949
Ear infection	26.64	9.83	112	118955	34320	79591001
Discomfort	26.63	9.83	97	118970	125520	79499801
Red blood cell sedimentation rate increased	26.53	9.83	18	119049	45924	79579397
Serotonin syndrome	26.37	9.83	135	118932	44892	79580429
Gastrointestinal haemorrhage	26.36	9.83	122	118945	147597	79477724
Medication error	26.19	9.83	184	118883	68458	79556863
Pneumocephalus	26.00	9.83	12	119055	342	79624979
Hyperkalaemia	25.83	9.83	86	118981	114312	79511009
Somnambulism	25.78	9.83	37	119030	5684	79619637
Bone marrow failure	25.74	9.83	23	119044	51084	79574237
Dysarthria	25.64	9.83	181	118886	67441	79557880
Status epilepticus	25.59	9.83	89	118978	24952	79600369
Chemical burn	25.54	9.83	14	119053	579	79624742
Melaena	25.52	9.83	32	119035	60858	79564463
Product prescribing error	25.29	9.83	18	119049	44795	79580526
Type I hypersensitivity	25.25	9.83	32	119035	4366	79620955
Wrong product administered	25.25	9.83	47	119020	8965	79616356
Road traffic accident	24.93	9.83	130	118937	43534	79581787
Intentional product use issue	24.76	9.83	341	118726	151771	79473550
Pneumocystis jirovecii pneumonia	24.38	9.83	9	119058	32499	79592822
Obesity	24.27	9.83	11	119056	35114	79590207
Dehydration	24.26	9.83	245	118822	247942	79377379
Respiratory tract infection bacterial	24.21	9.83	22	119045	2055	79623266
Meningitis chemical	24.14	9.83	10	119057	218	79625103
Therapeutic product effect incomplete	24.10	9.83	119	118948	141526	79483795
Platelet aggregation inhibition	23.90	9.83	9	119058	151	79625170
Irritable bowel syndrome	23.77	9.83	35	119032	62206	79563115
Diabetes mellitus	23.70	9.83	51	119016	78339	79546982
Victim of chemical submission	23.64	9.83	13	119054	541	79624780
Blood ethanol increased	23.50	9.83	14	119053	679	79624642
Inhibitory drug interaction	23.38	9.83	31	119036	4422	79620899
Toxicologic test abnormal	23.31	9.83	18	119049	1342	79623979
Treatment failure	23.20	9.83	154	118913	170332	79454989
Electrocardiogram QT prolonged	22.99	9.83	221	118846	90165	79535156
Congestive hepatopathy	22.87	9.83	31	119036	4516	79620805
COVID-19 immunisation	22.86	9.83	18	119049	1381	79623940
Sensorimotor disorder	22.62	9.83	15	119052	879	79624442
Product preparation error	22.58	9.83	35	119032	5758	79619563
Alcohol intolerance	22.42	9.83	12	119055	473	79624848
Nerve root injury	22.35	9.83	6	119061	30	79625291
Neurotoxicity	22.28	9.83	102	118965	32416	79592905
Spinal anaesthesia	22.25	9.83	7	119060	66	79625255
Delayed recovery from anaesthesia	22.05	9.83	19	119048	1654	79623667
Bursitis infective	21.79	9.83	17	119050	1287	79624034
Parophthalmia	21.72	9.83	11	119056	386	79624935
Punctate keratitis	21.29	9.83	15	119052	971	79624350
Respiratory tract infection	21.27	9.83	135	118932	48554	79576767
Normal newborn	21.23	9.83	38	119029	7034	79618287
Cholestasis	21.20	9.83	28	119039	52081	79573240
Atonic urinary bladder	21.04	9.83	7	119060	80	79625241
Hypercalcaemia	20.95	9.83	16	119051	38414	79586907
Hepatic function abnormal	20.93	9.83	49	119018	73058	79552263
Anxiety	20.86	9.83	502	118565	248010	79377311
Gait inability	20.72	9.83	35	119032	58882	79566439
Neuromuscular block prolonged	20.70	9.83	15	119052	1015	79624306
Glossoptosis	20.70	9.83	9	119058	222	79625099
Cardiotoxicity	20.66	9.83	52	119015	12187	79613134
Peripheral nerve injury	20.58	9.83	13	119054	701	79624620
Constipation	20.57	9.83	298	118769	282752	79342569
Dizziness	20.50	9.83	614	118453	525827	79099494
Upper airway obstruction	20.43	9.83	17	119050	1411	79623910
Paraplegia	20.35	9.83	31	119036	5022	79620299
Renal impairment	20.25	9.83	145	118922	157638	79467683
Diabetic ketoacidosis	20.20	9.83	13	119054	34109	79591212
Gastroenteritis	20.15	9.83	13	119054	34069	79591252
Product use issue	20.14	9.83	208	118859	209614	79415707
Ventricular extrasystoles	20.10	9.83	70	118997	19634	79605687
Amnesia	20.09	9.83	162	118905	62895	79562426
Multiple sclerosis relapse	19.98	9.83	24	119043	46509	79578812
Hepatocellular injury	19.95	9.83	25	119042	47568	79577753
Chest pain	19.90	9.83	299	118768	282005	79343316
Postoperative delirium	19.69	9.83	10	119057	353	79624968
Product contamination microbial	19.53	9.83	14	119053	932	79624389
Protein C increased	19.37	9.83	7	119060	104	79625217
Substance dependence	19.26	9.83	11	119056	493	79624828
Restlessness	19.15	9.83	127	118940	46365	79578956
Peritonitis	19.03	9.83	9	119058	28027	79597294
SARS-CoV-2 test negative	18.95	9.83	16	119051	1355	79623966
Osteonecrosis of jaw	18.87	9.83	22	119045	43204	79582117
Transient ischaemic attack	18.82	9.83	31	119036	52664	79572657
Post procedural complication	18.81	9.83	78	118989	23751	79601570
Infusion site discomfort	18.79	9.83	16	119051	1371	79623950
Dermatitis contact	18.75	9.83	47	119020	10986	79614335
Lung neoplasm malignant	18.75	9.83	9	119058	27783	79597538
Sensory loss	18.68	9.83	52	119015	12939	79612382
Coronary artery disease	18.65	9.83	44	119023	65430	79559891
Vasoplegia syndrome	18.64	9.83	25	119042	3605	79621716
Pupillary reflex impaired	18.62	9.83	24	119043	3329	79621992
Balance disorder	18.62	9.83	80	118987	98777	79526544
Harlequin syndrome	18.49	9.83	6	119061	63	79625258
Lymphadenopathy	18.39	9.83	32	119035	53215	79572106
Headache	18.30	9.83	794	118273	652978	78972343
Accidental poisoning	18.24	9.83	17	119050	1640	79623681
Cardiac failure	18.12	9.83	146	118921	154696	79470625
Angina pectoris	17.95	9.83	31	119036	51701	79573620
Prostate cancer	17.95	9.83	14	119053	33254	79592067
Neuromuscular blockade	17.83	9.83	11	119056	569	79624752
Pulmonary embolism	17.80	9.83	167	118900	171487	79453834
Bezoar	17.77	9.83	21	119046	2667	79622654
Brain death	17.68	9.83	31	119036	5646	79619675
Arthritis bacterial	17.68	9.83	41	119026	9125	79616196
Nasal congestion	17.66	9.83	57	119010	76495	79548826
Gait disturbance	17.43	9.83	212	118855	207294	79418027
Impaired driving ability	17.42	9.83	30	119037	5385	79619936
Phrenic nerve paralysis	17.36	9.83	9	119058	332	79624989
Pneumonia	17.23	9.83	808	118259	659438	78965883
Anticholinergic syndrome	17.23	9.83	24	119043	3587	79621734
Bladder cancer	17.21	9.83	4	119063	19522	79605799
Multiple allergies	17.20	9.83	44	119023	10416	79614905
Spinal epidural haemorrhage	17.14	9.83	7	119060	147	79625174
Spinal operation	17.04	9.83	37	119030	7880	79617441
Inappropriate antidiuretic hormone secretion	17.03	9.83	9	119058	26304	79599017
Accidental exposure to product	17.02	9.83	92	118975	31230	79594091
Pain	16.87	9.83	869	118198	702933	78922388
Upper respiratory tract infection	16.76	9.83	209	118858	90959	79534362
Glucose tolerance impaired	16.52	9.83	37	119030	8047	79617274
Metastases to liver	16.47	9.83	11	119056	28303	79597018
Neutropenic sepsis	16.45	9.83	10	119057	27054	79598267
Asthma	16.45	9.83	126	118941	134969	79490352
Dyspepsia	16.43	9.83	95	118972	108592	79516729
Blood lactic acid increased	16.38	9.83	49	119018	12695	79612626
Gastrooesophageal reflux disease	16.37	9.83	90	118977	104156	79521165
Hypercholesterolaemia	16.33	9.83	7	119060	23088	79602233
Paralysis	16.31	9.83	50	119017	13127	79612194
Application site alopecia	16.27	9.83	4	119063	13	79625308
Bradypnoea	16.25	9.83	31	119036	6021	79619300
Haemodynamic instability	16.24	9.83	60	119007	17322	79607999
Myoclonus	16.24	9.83	83	118984	27577	79597744
Full blood count abnormal	16.21	9.83	22	119045	40452	79584869
Tubulointerstitial nephritis	16.12	9.83	20	119047	38215	79587106
Deep vein thrombosis	16.06	9.83	110	118957	120809	79504512
Tracheal deviation	16.05	9.83	7	119060	174	79625147
Stridor	15.98	9.83	29	119038	5424	79619897
Foreign body in respiratory tract	15.91	9.83	9	119058	396	79624925
Eosinophilia	15.89	9.83	27	119040	45318	79580003
Hip arthroplasty	15.82	9.83	18	119049	35738	79589583
Axillary nerve injury	15.82	9.83	4	119063	15	79625306
Inflammation	15.81	9.83	79	118988	93674	79531647
Prescribed overdose	15.78	9.83	20	119047	37863	79587458
Uveitis	15.76	9.83	3	119064	16827	79608494
Nail bed tenderness	15.72	9.83	9	119058	405	79624916
Catecholamine crisis	15.72	9.83	5	119062	49	79625272
Intracranial hypotension	15.68	9.83	9	119058	407	79624914
Areflexia	15.68	9.83	29	119038	5505	79619816
Hypocalcaemia	15.49	9.83	32	119035	49892	79575429
Dyspnoea exertional	15.48	9.83	72	118995	87001	79538320
Delirium tremens	15.41	9.83	11	119056	727	79624594
Visceral oedema	15.39	9.83	6	119061	111	79625210
Brain stem syndrome	15.29	9.83	12	119055	916	79624405
Pancreatitis acute	15.22	9.83	32	119035	49572	79575749
Behavioural addiction	15.20	9.83	5	119062	55	79625266
Induced abortion failed	15.18	9.83	7	119060	199	79625122
Brachial plexus injury	15.10	9.83	6	119061	117	79625204
International normalised ratio increased	15.09	9.83	70	118997	84651	79540670
Jaundice	15.07	9.83	36	119031	53313	79572008
Substance-induced mood disorder	15.01	9.83	6	119061	119	79625202
Progressive multifocal leukoencephalopathy	14.95	9.83	6	119061	20594	79604727
Trigeminal palsy	14.90	9.83	4	119063	20	79625301
Incision site rash	14.90	9.83	4	119063	20	79625301
Physical assault	14.86	9.83	15	119052	1596	79623725
Anaphylactoid shock	14.85	9.83	11	119056	770	79624551
Neuropathy peripheral	14.85	9.83	137	118930	141168	79484153
Immunodeficiency	14.76	9.83	7	119060	21761	79603560
Diabetes mellitus inadequate control	14.70	9.83	9	119058	24255	79601066
Drug eruption	14.64	9.83	27	119040	43908	79581413
Procedural complication	14.62	9.83	35	119032	7948	79617373
Red blood cell count decreased	14.57	9.83	41	119026	57472	79567849
Infusion site nodule	14.52	9.83	8	119059	334	79624987
Neoplasm progression	14.50	9.83	35	119032	51647	79573674
Spinal epidural haematoma	14.45	9.83	14	119053	1418	79623903
Intentional dose omission	14.40	9.83	37	119030	8780	79616541
Proctalgia	14.35	9.83	40	119027	9961	79615360
Accelerated idioventricular rhythm	14.25	9.83	7	119060	230	79625091
Psychiatric disorder prophylaxis	14.24	9.83	5	119062	68	79625253
Respiratory tract infection viral	14.24	9.83	24	119043	4235	79621086
Ventricular hypokinesia	14.20	9.83	38	119029	9241	79616080
Infusion site rash	14.17	9.83	15	119052	1687	79623634
Skin exfoliation	14.17	9.83	39	119028	55061	79570260
Pulmonary toxicity	14.16	9.83	47	119020	12867	79612454
Palpitations	14.07	9.83	121	118946	126489	79498832
Haematotoxicity	14.04	9.83	3	119064	15516	79609805
Hypoxic-ischaemic encephalopathy	14.02	9.83	34	119033	7786	79617535
Abortion spontaneous	14.01	9.83	14	119053	29493	79595828
Irregular breathing	13.86	9.83	9	119058	509	79624812
Colitis ulcerative	13.80	9.83	19	119048	34723	79590598
Sexual abuse	13.79	9.83	7	119060	247	79625074
Mean arterial pressure decreased	13.70	9.83	8	119059	374	79624947
Myelodysplastic syndrome	13.69	9.83	15	119052	30286	79595035
Opisthotonus	13.68	9.83	10	119057	686	79624635
Metastases to lung	13.67	9.83	5	119062	18158	79607163
Oxidative stress	13.64	9.83	4	119063	29	79625292
Brain injury	13.61	9.83	43	119024	11474	79613847
Vitreous disorder	13.61	9.83	7	119060	254	79625067
Fall	13.46	9.83	593	118474	487036	79138285
Foreign body	13.46	9.83	19	119048	2875	79622446
Spinal cord oedema	13.45	9.83	8	119059	387	79624934
Graft versus host disease	13.40	9.83	3	119064	15023	79610298
Angina unstable	13.40	9.83	4	119063	16523	79608798
Injection site ulcer	13.39	9.83	10	119057	709	79624612
Gastric disorder	13.38	9.83	22	119045	37411	79587910
Glycosylated haemoglobin increased	13.36	9.83	6	119061	19254	79606067
Euphoric mood	13.22	9.83	33	119034	7693	79617628
Acute pulmonary oedema	13.20	9.83	49	119018	14181	79611140
Muscular weakness	13.20	9.83	165	118902	160564	79464757
Injection site reaction	13.19	9.83	40	119027	54745	79570576
Injection site joint infection	13.18	9.83	4	119063	33	79625288
Blood glucose increased	13.18	9.83	109	118958	114866	79510455
Foot deformity	13.15	9.83	10	119057	24064	79601257
Vaginal abscess	13.14	9.83	8	119059	404	79624917
Left ventricle outflow tract obstruction	13.12	9.83	8	119059	405	79624916
Familial periodic paralysis	13.07	9.83	6	119061	169	79625152
Creatinine renal clearance decreased	13.05	9.83	6	119061	18996	79606325
Spinal stroke	12.98	9.83	4	119063	35	79625286
Implant site bruising	12.89	9.83	7	119060	284	79625037
Intentional product misuse to child	12.85	9.83	5	119062	92	79625229
Skin lesion	12.83	9.83	27	119040	41817	79583504
Eczema	12.80	9.83	26	119041	40792	79584529
Rheumatoid nodule	12.79	9.83	5	119062	17433	79607888
Infusion site irritation	12.75	9.83	10	119057	763	79624558
Reperfusion arrhythmia	12.69	9.83	7	119060	293	79625028
Toxic epidermal necrolysis	12.66	9.83	30	119037	44551	79580770
Peripheral venous disease	12.63	9.83	4	119063	15905	79609416
Alcoholic pancreatitis	12.53	9.83	6	119061	186	79625135
Cholestasis of pregnancy	12.53	9.83	11	119056	982	79624339
Femoral nerve injury	12.50	9.83	4	119063	40	79625281
Upper gastrointestinal haemorrhage	12.44	9.83	27	119040	41353	79583968
Vitamin D increased	12.44	9.83	9	119058	608	79624713
Anaphylactoid reaction	12.43	9.83	26	119041	5396	79619925
Paranasal cyst	12.41	9.83	8	119059	447	79624874
Sleep disorder	12.36	9.83	76	118991	85601	79539720
Hepatic fibrosis	12.36	9.83	31	119036	7249	79618072
Ventricular arrhythmia	12.33	9.83	35	119032	8805	79616516
Palmar-plantar erythrodysaesthesia syndrome	12.29	9.83	19	119048	33115	79592206
Symblepharon	12.27	9.83	6	119061	195	79625126
Heliotrope rash	12.24	9.83	6	119061	196	79625125
Gastritis alcoholic	12.24	9.83	4	119063	43	79625278
Injection site discharge	12.21	9.83	10	119057	812	79624509
Body dysmorphic disorder	12.17	9.83	7	119060	318	79625003
Fibromyalgia	12.16	9.83	52	119015	64288	79561033
Non-cardiogenic pulmonary oedema	12.11	9.83	13	119054	1486	79623835
Anal skin tags	12.06	9.83	8	119059	469	79624852
Neuroleptic malignant syndrome	12.06	9.83	14	119053	27545	79597776
Cerebral haemorrhage	11.92	9.83	45	119022	57628	79567693
Delirium	11.90	9.83	185	118882	84442	79540879
Wheezing	11.88	9.83	114	118953	116550	79508771
Benzodiazepine drug level therapeutic	11.85	9.83	4	119063	48	79625273
Alcoholic	11.85	9.83	4	119063	48	79625273
Lymphopenia	11.85	9.83	17	119050	30540	79594781
Acute myocardial infarction	11.82	9.83	67	119000	76969	79548352
Femur fracture	11.80	9.83	25	119042	38627	79586694
Suicidal behaviour	11.80	9.83	19	119048	3228	79622093
Airway peak pressure increased	11.76	9.83	7	119060	339	79624982
Pulmonary congestion	11.75	9.83	75	118992	27025	79598296
Staphylococcal infection	11.75	9.83	136	118931	58159	79567162
Neutrophil count decreased	11.73	9.83	87	118980	93872	79531449
Apnoeic attack	11.73	9.83	9	119058	665	79624656
Vascular resistance systemic decreased	11.63	9.83	6	119061	219	79625102
Blood pressure decreased	11.63	9.83	211	118856	99255	79526066
Myokymia	11.63	9.83	5	119062	120	79625201
Pain in jaw	11.62	9.83	33	119034	46118	79579203
Pancreatic carcinoma	11.54	9.83	3	119064	13574	79611747
Abnormal sleep-related event	11.52	9.83	10	119057	879	79624442
Thrombotic microangiopathy	11.51	9.83	8	119059	20161	79605160
Premature delivery	11.48	9.83	67	119000	23400	79601921
Poor quality product administered	11.47	9.83	20	119047	3625	79621696
Device expulsion	11.46	9.83	13	119054	25848	79599473
Therapeutic response decreased	11.46	9.83	56	119011	66797	79558524
Drug ineffective for unapproved indication	11.45	9.83	122	118945	51116	79574205
Streptococcal infection	11.40	9.83	34	119033	8796	79616525
Infusion site streaking	11.33	9.83	8	119059	520	79624801
Injection site bruising	11.32	9.83	28	119039	40974	79584347
Nerve block	11.28	9.83	9	119058	704	79624617
Throat irritation	11.28	9.83	28	119039	40918	79584403
Visual acuity reduced	11.24	9.83	79	118988	29390	79595931
Anal ulcer	11.22	9.83	12	119055	1366	79623955
Coccygectomy	11.17	9.83	3	119064	15	79625306
Rash pruritic	11.15	9.83	62	119005	71567	79553754
Foetal heart rate abnormal	11.09	9.83	7	119060	377	79624944
Haemorrhoids	11.06	9.83	78	118989	29050	79596271
Haematuria	11.04	9.83	59	119008	68777	79556544
Gun shot wound	10.99	9.83	11	119056	1159	79624162
Myalgia	10.98	9.83	203	118864	185438	79439883
Transferrin decreased	10.97	9.83	7	119060	384	79624937
Liquid product physical issue	10.96	9.83	11	119056	1163	79624158
Enterocolitis	10.91	9.83	4	119063	14508	79610813
Fatty liver alcoholic	10.85	9.83	4	119063	63	79625258
Chest discomfort	10.85	9.83	143	118924	137901	79487420
Eosinophil count increased	10.85	9.83	6	119061	17099	79608222
Lung disorder	10.84	9.83	73	118994	80484	79544837
Coma scale abnormal	10.81	9.83	33	119034	8645	79616676
Drug tolerance decreased	10.78	9.83	3	119064	12975	79612346
Myotonic dystrophy	10.72	9.83	5	119062	146	79625175
Myopathy	10.66	9.83	9	119058	20554	79604767
Intraocular pressure fluctuation	10.63	9.83	4	119063	67	79625254
Hepatitis C virus test positive	10.56	9.83	7	119060	410	79624911
Repetitive strain injury	10.54	9.83	5	119062	152	79625169
Stab wound	10.46	9.83	6	119061	271	79625050
Kidney infection	10.44	9.83	62	119005	21789	79603532
Stress	10.43	9.83	172	118895	79440	79545881
Ascites	10.40	9.83	68	118999	75494	79549827
Drug diversion	10.38	9.83	11	119056	1239	79624082
Retrograde amnesia	10.35	9.83	8	119059	597	79624724
Corneal opacity	10.34	9.83	10	119057	1010	79624311
Vascular stenosis	10.34	9.83	8	119059	598	79624723
Full blood count decreased	10.32	9.83	15	119052	26804	79598517
Oesophageal obstruction	10.29	9.83	10	119057	1016	79624305
Postmortem blood drug level increased	10.28	9.83	9	119058	800	79624521
Sinus arrest	10.28	9.83	19	119048	3603	79621718
Haemolytic anaemia	10.26	9.83	7	119060	17813	79607508
Brachial artery entrapment syndrome	10.26	9.83	4	119063	74	79625247
Insomnia	10.26	9.83	283	118784	244887	79380434
Eyelid ptosis	10.22	9.83	38	119029	11006	79614315
Hypoaesthesia oral	10.20	9.83	45	119022	14079	79611242
Abdominal pain lower	10.18	9.83	20	119047	31762	79593559
Air embolism	10.12	9.83	7	119060	440	79624881
Hepatitis cholestatic	10.11	9.83	4	119063	13848	79611473
Immune reconstitution inflammatory syndrome	10.10	9.83	4	119063	13837	79611484
Osteoporosis	10.06	9.83	44	119023	54068	79571253
Photosensitivity reaction	10.06	9.83	10	119057	21117	79604204
Spinal cord injury	10.06	9.83	11	119056	1284	79624037
Fluid retention	10.03	9.83	62	119005	69747	79555574
Panniculitis	10.02	9.83	3	119064	12368	79612953
Dry skin	9.97	9.83	60	119007	67935	79557386
Incision site swelling	9.94	9.83	6	119061	298	79625023
Liver function test abnormal	9.94	9.83	56	119011	64419	79560902
Cardiac death	9.92	9.83	12	119055	1562	79623759
Device ineffective	9.91	9.83	5	119062	174	79625147
Hypothermia	9.89	9.83	63	119004	22683	79602638
Stevens-Johnson syndrome	9.86	9.83	28	119039	39138	79586183
Cerebral infarction	9.86	9.83	35	119032	45641	79579680
Rectal haemorrhage	9.84	9.83	70	118997	76230	79549091
Orbital infection	9.84	9.83	4	119063	83	79625238
Renal cancer	9.84	9.83	3	119064	12223	79613098
Tracheitis	9.83	9.83	11	119056	1317	79624004

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	53.98	21.16	9	5	72	89706

Pharmacologic Action:

Source	Code	Description
ATC	D08AJ01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D09AA05	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	D09AA11	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	R02AA16	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
CHEBI has role	CHEBI:27780	Detergents
CHEBI has role	CHEBI:33282	bactericides
CHEBI has role	CHEBI:35195	surfactant
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D003902	Detergents
MeSH PA	D010592	Pharmaceutic Aids
MeSH PA	D011310	Preservatives, Pharmaceutical
MeSH PA	D013501	Surface-Active Agents
CHEBI has role	CHEBI:51076	Marine pesticide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Uveitis	indication	128473001	DOID:13141
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Allergic otitis externa	indication	405821001
Itching of skin	indication	418363000
Itching of ear	indication	699392007
Post-Op Ocular Inflammation	indication
Suppression of the Gag Reflex	indication
Mouth Irritation	indication
Prevent Minor Bacterial Skin Infection	indication
Minor Skin Wound Pain	indication
Bacterial septicemia	contraindication	10001005	DOID:0040085
Hypocupremia	contraindication	19577007
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006
Shock	contraindication	27942005
Methemoglobinemia	contraindication	38959009	DOID:10783
Conduction disorder of the heart	contraindication	44808001
Perforation of tympanic membrane	contraindication	60442001
Diabetes mellitus	contraindication	73211009	DOID:9351
Decreased respiratory function	contraindication	80954004
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Deficiency of cytochrome-b>5< reductase	contraindication	124184009
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Condyloma acuminatum	contraindication	240542006	DOID:11168
Peripheral vascular disease	contraindication	400047006
Blister	contraindication	417237009
Denuded skin	contraindication	418242004
Inflammatory dermatosis	contraindication	703938007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018249	VUID
N0000178890	NUI
D00857	KEGG_DRUG
8001-54-5	SECONDARY_CAS_RN
4018249	VANDF
4023321	VANDF
C0005025	UMLSCUI
CHEBI:3020	CHEBI
CHEMBL1187417	ChEMBL_ID
CHEMBL502109	ChEMBL_ID
CHEMBL1907001	ChEMBL_ID
D001548	MESH_DESCRIPTOR_UI
DB11105	DRUGBANK_ID
7N6JUD5X6Y	UNII
2330	PUBCHEM_CID
DB13282	DRUGBANK_ID
1311593	RXNORM
4255	MMSL
5003	MMSL
003141	NDDF
005466	NDDF
006369	NDDF
373549009	SNOMEDCT_US
64686009	SNOMEDCT_US
735078001	SNOMEDCT_US
90370005	SNOMEDCT_US
1168	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Stay Safe Hand Sanitizer Alcohol Free	HUMAN OTC DRUG LABEL	1	0295-9049	GEL	0.13 mg	TOPICAL	OTC monograph not final	10 sections
Hand wash	HUMAN OTC DRUG LABEL	1	0363-0082	SOAP	1.30 mg	TOPICAL	OTC monograph not final	11 sections
Hand wash	HUMAN OTC DRUG LABEL	1	0363-0082	SOAP	1.30 mg	TOPICAL	OTC monograph not final	11 sections
Hand wash	HUMAN OTC DRUG LABEL	1	0363-0082	SOAP	1.30 mg	TOPICAL	OTC monograph not final	11 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-0242	SOAP	130 mg	TOPICAL	OTC monograph not final	12 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-0242	SOAP	130 mg	TOPICAL	OTC monograph not final	12 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-0242	SOAP	130 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Nicefresh scent	HUMAN OTC DRUG LABEL	1	0363-0554	CLOTH	0.12 g	TOPICAL	OTC monograph not final	11 sections
First Aid Antiseptic Wipes	HUMAN OTC DRUG LABEL	1	0363-0589	CLOTH	0.00 mg	TOPICAL	OTC monograph not final	11 sections
First Aid Antiseptic Wipes	HUMAN OTC DRUG LABEL	1	0363-0589	CLOTH	0.00 mg	TOPICAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.13 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.13 g	ORAL	OTC monograph not final	9 sections
Hand wipes	HUMAN OTC DRUG LABEL	1	0363-0644	CLOTH	1.30 g	TOPICAL	OTC monograph not final	12 sections
Hand wipes	HUMAN OTC DRUG LABEL	1	0363-0644	CLOTH	1.30 g	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0651	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0651	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0683	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	11 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0683	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	11 sections
PM Toothache Relief	HUMAN OTC DRUG LABEL	4	0363-1623	PASTE	0.26 g	DENTAL	OTC monograph not final	8 sections
Antibacterial Lidocaine Wound Gel	HUMAN OTC DRUG LABEL	2	0363-1652	GEL	0.13 g	TOPICAL	OTC monograph not final	12 sections
First Aid AntisepticWell at Walgreens	HUMAN OTC DRUG LABEL	2	0363-3286	SPRAY	0.13 g	TOPICAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.13 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.13 g	ORAL	OTC monograph not final	9 sections
Walgreen Maximum strengthpain relieving cleansing	HUMAN OTC DRUG LABEL	2	0363-7020	LIQUID	0.13 g	TOPICAL	OTC monograph not final	14 sections
Walgreen Maximum strengthpain relieving cleansing	HUMAN OTC DRUG LABEL	2	0363-7020	LIQUID	0.13 g	TOPICAL	OTC monograph not final	14 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0363-7110	LIQUID	1.25 g	TOPICAL	OTC monograph not final	11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL	HUMAN OTC DRUG LABEL	1	0363-7210	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
WalgreensANTIBACTERIAL HAND REFILL	HUMAN OTC DRUG LABEL	1	0363-7211	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections