benzalkonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quaternary ammonium compounds	3017	139-07-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzalkonium chloride benzalkonium benzyldodecyldimethylammonium chloride benzododecinium	A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics. Molecular weight: 304.54 Formula: C21H38N CLOGP: 3.18 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: ALOGS: -7.85 ROTB: 13

Molecule

Description

Molfile Inchi Smiles

Synonyms:

benzalkonium chloride
benzalkonium
benzyldodecyldimethylammonium chloride
benzododecinium

A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.

Molecular weight: 304.54
Formula: C21H38N
CLOGP: 3.18
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA:
ALOGS: -7.85
ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	3410.74	9.93	2268	87154	143405	63256195
Toxicity to various agents	2128.44	9.93	2149	87273	245101	63154499
Drug abuse	1129.35	9.93	884	88538	71634	63327966
Cardio-respiratory arrest	726.18	9.93	632	88790	59327	63340273
Intentional overdose	521.79	9.93	581	88841	73571	63326029
Local anaesthetic systemic toxicity	450.39	9.93	125	89297	774	63398826
Overdose	405.08	9.93	642	88780	114436	63285164
Cardiac arrest	383.34	9.93	557	88865	91988	63307612
Alcohol interaction	325.70	9.93	124	89298	2285	63397315
Suicide attempt	274.77	9.93	382	89040	60536	63339064

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	3971.46	11.21	2305	56074	96791	34801761
Toxicity to various agents	2728.55	11.21	2414	55965	197948	34700604
Completed suicide	2579.49	11.21	1750	56629	96418	34802134
Cardio-respiratory arrest	582.19	11.21	581	57798	54692	34843860
Intentional overdose	506.36	11.21	484	57895	43190	34855362
Overdose	488.43	11.21	677	57702	90382	34808170
Alcohol abuse	408.09	11.21	185	58194	4505	34894047
Alcohol interaction	386.58	11.21	155	58224	2758	34895794
Intentional product misuse	347.14	11.21	404	57975	45207	34853345
Suspected suicide	270.03	11.21	140	58239	4608	34893944

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	5901.05	9.83	3968	115099	241799	79383522
Drug abuse	4976.63	9.83	3063	116004	159628	79465693
Toxicity to various agents	4850.20	9.83	4402	114665	417138	79208183
Cardio-respiratory arrest	1343.34	9.83	1187	117880	107323	79517998
Intentional overdose	886.90	9.83	935	118132	105025	79520296
Overdose	790.78	9.83	1162	117905	183044	79442277
Cardiac arrest	618.13	9.83	1000	118067	171096	79454225
Alcohol interaction	610.01	9.83	241	118826	4633	79620688
Local anaesthetic systemic toxicity	512.54	9.83	145	118922	909	79624412
Suspected suicide	489.98	9.83	262	118805	10314	79615007

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FDA Adverse Event Reporting System (Pediatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	53.98	21.16	9	5	72	89706

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Pharmacologic Action:

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Source	Code	Description
ATC	D08AJ01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D09AA05	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	D09AA11	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	R02AA16	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
CHEBI has role	CHEBI:27780	Detergents
CHEBI has role	CHEBI:33282	bactericides
CHEBI has role	CHEBI:35195	surfactant
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants
CHEBI has role	CHEBI:51076	Marine pesticide

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Uveitis	indication	128473001	DOID:13141
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Allergic otitis externa	indication	405821001
Itching of skin	indication	418363000
Itching of ear	indication	699392007
Post-Op Ocular Inflammation	indication
Suppression of the Gag Reflex	indication
Mouth Irritation	indication

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
003141	NDDF
005466	NDDF
006369	NDDF
1168	INN_ID
1311593	RXNORM
2330	PUBCHEM_CID
373549009	SNOMEDCT_US
4018249	VUID
4018249	VANDF
4023321	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.13 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.13 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.13 g	ORAL	OTC monograph not final	9 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.13 g	ORAL	OTC monograph not final	9 sections
Antibacterial Lidocaine Wound Gel	HUMAN OTC DRUG LABEL	2	0363-1652	GEL	0.13 g	TOPICAL	OTC monograph not final	12 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0363-7110	LIQUID	1.25 g	TOPICAL	OTC monograph not final	11 sections
First Aid Antiseptic Wipes	HUMAN OTC DRUG LABEL	1	0363-0589	CLOTH	0.00 mg	TOPICAL	OTC monograph not final	11 sections
First Aid Antiseptic Wipes	HUMAN OTC DRUG LABEL	1	0363-0589	CLOTH	0.00 mg	TOPICAL	OTC monograph not final	11 sections
First Aid AntisepticWell at Walgreens	HUMAN OTC DRUG LABEL	2	0363-3286	SPRAY	0.13 g	TOPICAL	OTC monograph not final	11 sections
Hand wash	HUMAN OTC DRUG LABEL	1	0363-0082	SOAP	1.30 mg	TOPICAL	OTC monograph not final	11 sections

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