pyrantel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anthelminthics (undefined group) 2999 15686-83-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyrantel
  • pyrequan
  • pyrantel pamoate
  • pyrantel tartrate
Broad spectrum anthelmintic for livestock.
  • Molecular weight: 206.31
  • Formula: C11H14N2S
  • CLOGP: 3.03
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 15.60
  • ALOGS: -3.24
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.75 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 55.08 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 10 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.321 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.330 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 40.644 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 8.222 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 63.370 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 84.150 % High 1
herg hERG pIC50 4.993 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.027 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 8.375 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 69.170 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TTK 36
kinase-selectivity-class AXL,BRAF,GRK2,STK33,TTK 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.575 High 1
mh-clint Mouse hepatocyte intrinsic clearance 85.114 High 1
mppb Mouse plasma protein binding (% unbound) 68.880 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.615 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 67.330 % High 1
rh-clint Rat hepatocyte intrinsic clearance 125.026 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 90.080 % High 1
rppb Rat plasma protein binding (% unbound) 72.550 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 887.156 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1974 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P02CC01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Tetrahydropyrimidine derivatives
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000969 Antinematodal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009467 Neuromuscular Depolarizing Agents
CHEBI has role CHEBI:35443 anthelminthic drug
CHEBI has role CHEBI:35444 antinematodal drug

Related Drugs by ATC class:

P02CC Tetrahydropyrimidine derivatives 1 drug
oxantel

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ascariasis indication 2435008 DOID:456
Mixed intestinal infection due to Class Cestoda and/or Class Trematoda and/or Phylum Nemata indication 90679001
Enterobiasis indication 266162007
Infection by Moniliformis off-label use 2341000
Trichostrongyliasis off-label use 33710003 DOID:1254
Infection by Uncinaria off-label use 414490001
Necator Americanus Infection off-label use
Ancylostoma Duodenale Infection off-label use
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Removal and control of large roundworms, Toxocara canis Indication
Dogs Removal and control of large roundworms, Toxascaris leonin Indication
Dogs Removal and control of hookworms, Ancylostoma caninum Indication
Dogs Removal and control of hookworms, Uncinaria stenocephala Indication
Horses Removal of large strongyles, Strongylus vulgaris Indication
Horses Removal of large strongyles, Strongylus edentatus Indication
Horses Removal of large strongyles, Strongylus equinus Indication
Horses Removal of pinworms, Oxyuris equi Indication
Horses Removal of large roundworms, Parascaris Indication
Swine Removal and control of large roundworm, Ascaris suum Indication
Swine Prevention of migration and establishment of large roundworms (Ascaris suum) infections Indication
Swine Prevention of establishment of nodular worms (Oesophagostomum) infections Indication
Swine Removal and control of large roundworm, Ascaris suum Indication
Swine Removal and control of nodular worm, Oesophagostomum radiatum Indication

🐶 Veterinary products

ProductApplicantIngredients
Banminth, Strongid Zoetis Inc. 1
Banminth 48 Phibro Animal Health Corp. 1
Strongid T Zoetis Inc. 1
Purina Horse & Colt Wormer Bimeda Animal Health Limited 1
Banminth / Mecadox Phibro Animal Health Corp. 2
Nemex, Nemex-2, RFD Liquid Wormer Zoetis Inc. 1
Dog Wormer Tablets Farnam Companies Inc. 1
Tylan and Banminth Phibro Animal Health Corp. 2
LINCOMIX and Banminth Phibro Animal Health Corp. 2
Ban-A-Worm Py. Tartrate, Ban-A-Worm Pyrantel Tartrate Ton Pack ADM Animal Nutrition 1
Banminth-P Paste, Strongid Paste Zoetis Inc. 1
LINCOMIX and Banminth Zoetis Inc. 2
Adams, D-Worm, Dog Wormer Chewable Tablets Farnam Companies Inc. 1
Strongid 48 Zoetis Inc. 1
Heartgard Plus Boehringer lngelheim Animal Health USA Inc. 2
Drontal Plus, Drontal Plus Taste Tabs, Quad Dewormer Elanco US Inc. 3
Drontal Tablets Elanco US Inc. 2
Iverhart Max Virbac AH Inc. 3
Sentry HC Worm X Plus Virbac AH Inc. 2
IVERHART MAX Chew Virbac AH Inc. 3
Simparica Trio Zoetis Inc. 3
Liqui-Vict 2X Happy Jack Inc. 1
PyrantelCare Farnam Companies Inc. 1
Anthelban V Elanco US Inc. 1
Pyrantel Pamoate Suspension, Pyrantel Pamoate Suspension-2.27mg, Pyrantel Pamoate Suspension-4.54mg Cronus Pharma Specialities India Private Limited 1
Pyrantel Pamoate Chewable Tablets Virbac AH Inc. 1
Continuex Farnam Companies Inc. 1
Iverhart Plus Flavored Chewables Virbac AH Inc. 2
Tri-Heart Plus Chewable Tablets Heska Corp. 2
Pyrantel Pamoate Paste Farnam Companies Inc. 1
Exodus Paste, Exodus Multi Dose Bimeda Animal Health Limited 1
Primex 2-X, Primex Canine First Priority Inc. 1
Primex Equine First Priority Inc. 1
Primex First Priority Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Acetylcholinesterase Enzyme WOMBAT-PK

External reference:

IDSource
4019920 VUID
N0000148005 NUI
D00486 KEGG_DRUG
22204-24-6 SECONDARY_CAS_RN
4019104 VANDF
4019920 VANDF
C0034235 UMLSCUI
CHEBI:8654 CHEBI
CHEMBL1626223 ChEMBL_ID
DB11156 DRUGBANK_ID
CHEMBL1599768 ChEMBL_ID
D011715 MESH_DESCRIPTOR_UI
708857 PUBCHEM_CID
2228 INN_ID
4QIH0N49E7 UNII
2197593 RXNORM
4963 MMSL
5388 MMSL
5389 MMSL
d01123 MMSL
002986 NDDF
004115 NDDF
25013003 SNOMEDCT_US
36068003 SNOMEDCT_US
387193008 SNOMEDCT_US
96117000 SNOMEDCT_US
D011716 MESH_DESCRIPTOR_UI
CHEMBL1585303 ChEMBL_ID
33401-94-4 SECONDARY_CAS_RN
D011717 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Walgreens Pinworm Medicine HUMAN OTC DRUG LABEL 1 0363-0618 SUSPENSION 144 mg ORAL OTC Monograph Drug 10 sections
Pinworm Medicine HUMAN OTC DRUG LABEL 1 10956-618 SUSPENSION 144 mg ORAL OTC monograph final 10 sections
PinwormMedicine HUMAN OTC DRUG LABEL 1 10956-778 SUSPENSION 144 mg ORAL OTC Monograph Drug 10 sections
pinworm treatment HUMAN OTC DRUG LABEL 1 46122-825 SUSPENSION 144 mg ORAL OTC Monograph Drug 13 sections
Pyrantel Pamoate HUMAN OTC DRUG LABEL 1 51072-088 SUSPENSION 50 mg ORAL OTC Monograph Drug 14 sections
PARASITOL HUMAN OTC DRUG LABEL 1 53145-101 SUSPENSION 144 mg ORAL OTC Monograph Drug 9 sections
MebendamaXPinworm HUMAN OTC DRUG LABEL 1 55758-441 TABLET 180 mg ORAL OTC Monograph Drug 11 sections
Pyrantel Pamoate HUMAN OTC DRUG LABEL 1 58988-1760 TABLET 180 mg ORAL OTC MONOGRAPH FINAL 10 sections
Pyrantel Pamoate HUMAN OTC DRUG LABEL 1 58988-1770 SUSPENSION 144 mg ORAL OTC Monograph Drug 11 sections
Pinworm Treatment HUMAN OTC DRUG LABEL 1 59779-538 SUSPENSION 144 mg ORAL OTC monograph final 13 sections
Pyrantel Pamoate HUMAN OTC DRUG LABEL 1 62337-415 SUSPENSION 50 mg ORAL OTC Monograph Drug 13 sections
PinwormMedicine HUMAN OTC DRUG LABEL 1 63187-586 SUSPENSION 144 mg ORAL OTC monograph final 10 sections
Pronto Plus Pinworm Treatment HUMAN OTC DRUG LABEL 1 63736-240 LIQUID 5 mL ORAL OTC MONOGRAPH FINAL 14 sections
pinworm treatment HUMAN OTC DRUG LABEL 1 69452-515 SUSPENSION 144 mg ORAL OTC Monograph Drug 13 sections
VRMX 500 HUMAN OTC DRUG LABEL 1 69729-141 TABLET 180 mg ORAL OTC Monograph Drug 13 sections
Lombrix HUMAN OTC DRUG LABEL 1 69729-807 TABLET 180 mg ORAL OTC Monograph Drug 13 sections
CVS Pinworm Treatment HUMAN OTC DRUG LABEL 1 69842-618 SUSPENSION 144 mg ORAL OTC Monograph Drug 10 sections
Parasitexx HUMAN OTC DRUG LABEL 1 70242-134 SUSPENSION 144 mg ORAL OTC monograph final 12 sections
PinAway HUMAN OTC DRUG LABEL 1 70309-080 SUSPENSION 144 mg ORAL OTC monograph final 13 sections
pinworm treatment HUMAN OTC DRUG LABEL 1 70677-1312 SUSPENSION 144 mg ORAL OTC Monograph Drug 13 sections
PINRID HUMAN OTC DRUG LABEL 1 73581-111 TABLET 250 mg ORAL OTC Monograph Drug 13 sections
PINRID HUMAN OTC DRUG LABEL 1 73581-112 TABLET 250 mg ORAL OTC Monograph Drug 12 sections
PINRID HUMAN OTC DRUG LABEL 1 73581-113 TABLET 250 mg ORAL OTC Monograph Drug 12 sections
DEWORMER FOR DOG HUMAN OTC DRUG LABEL 1 87276-262 SUSPENSION 4.54 mg ORAL OTC Monograph Drug 8 sections