somatostatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2997 38916-34-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • somatostatin
  • aminopan
  • growth hormone release-inhibiting factor
  • somatotropin release-inhibiting hormone
  • SRIF-14
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
  • Molecular weight: 1637.90
  • Formula: C76H104N18O19S2
  • CLOGP: -1.45
  • LIPINSKI: 3
  • HAC: 37
  • HDO: 22
  • TPSA: 613.23
  • ALOGS: -4.90
  • ROTB: 26

Drug dosage:

DoseUnitRoute
6 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Administration site abscess 48.57 43.34 5 242 18 50604859
Administration site induration 47.96 43.34 5 242 21 50604856
Administration site discharge 47.59 43.34 5 242 23 50604854
Administration site odour 45.68 43.34 5 242 36 50604841
Injection site cyst 43.86 43.34 5 242 54 50604823

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastric varices 53.48 32.86 8 444 522 64497758
Administration site induration 46.74 32.86 5 447 18 64498262
Administration site abscess 46.74 32.86 5 447 18 64498262
Administration site discharge 45.25 32.86 5 447 26 64498254
Administration site odour 45.09 32.86 5 447 27 64498253
Administration site haemorrhage 42.96 32.86 5 447 44 64498236
Injection site cyst 40.97 32.86 5 447 68 64498212
Buttock injury 37.67 32.86 5 447 136 64498144
Portal hypertension 33.81 32.86 8 444 6211 64492069

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01CB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
HYPOTHALAMIC HORMONES
Somatostatin and analogues
MeSH PA D006728 Hormones

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.02 acidic
pKa2 12.17 acidic
pKa3 12.57 acidic
pKa4 12.85 acidic
pKa5 13.02 acidic
pKa6 13.2 acidic
pKa7 13.52 acidic
pKa8 13.6 acidic
pKa9 13.77 acidic
pKa10 13.88 acidic
pKa11 11.11 Basic
pKa12 10.51 Basic
pKa13 8.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Somatostatin receptor type 2 GPCR AGONIST Ki 10.46 CHEMBL IUPHAR
Somatostatin receptor type 3 GPCR AGONIST Ki 10 CHEMBL IUPHAR
Somatostatin receptor type 5 GPCR AGONIST Ki 9.85 CHEMBL IUPHAR
Somatostatin receptor type 4 GPCR AGONIST Ki 9.23 CHEMBL IUPHAR
Somatostatin receptor type 1 GPCR AGONIST Ki 9.54 CHEMBL IUPHAR
Somatostatin receptor GPCR IC50 5.89 CHEMBL
Mu-type opioid receptor GPCR IC50 8.22 CHEMBL
Somatostatin receptor GPCR IC50 9.70 CHEMBL
Delta-type opioid receptor GPCR IC50 5.70 CHEMBL
Somatostatin receptor type 2 GPCR IC50 9.55 CHEMBL
Somatostatin receptor type 3 GPCR IC50 10.10 CHEMBL
Somatostatin receptor type 5 GPCR IC50 9.07 CHEMBL

External reference:

IDSource
N0000007997 NUI
D07431 KEGG_DRUG
C0037659 UMLSCUI
CHEBI:64628 CHEBI
CHEMBL1823872 ChEMBL_ID
D013004 MESH_DESCRIPTOR_UI
DB09099 DRUGBANK_ID
2019 IUPHAR_LIGAND_ID
4311 INN_ID
6E20216Q0L UNII
16129706 PUBCHEM_CID
9939 RXNORM
005072 NDDF
49722008 SNOMEDCT_US
57819002 SNOMEDCT_US

Pharmaceutical products:

None