somatostatin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2997 38916-34-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • somatostatin
  • aminopan
  • growth hormone release-inhibiting factor
  • somatotropin release-inhibiting hormone
  • SRIF-14
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
  • Molecular weight: 1637.90
  • Formula: C76H104N18O19S2
  • CLOGP: -1.46
  • LIPINSKI: 3
  • HAC: 37
  • HDO: 22
  • TPSA: 613.23
  • ALOGS: -4.90
  • ROTB: 26

Drug dosage:

DoseUnitRoute
6 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01CB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
HYPOTHALAMIC HORMONES
Somatostatin and analogues
MeSH PA D006728 Hormones

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.02 acidic
pKa2 12.17 acidic
pKa3 12.57 acidic
pKa4 12.85 acidic
pKa5 13.02 acidic
pKa6 13.2 acidic
pKa7 13.52 acidic
pKa8 13.6 acidic
pKa9 13.77 acidic
pKa10 13.88 acidic
pKa11 11.11 Basic
pKa12 10.51 Basic
pKa13 8.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Somatostatin receptor type 2 GPCR AGONIST Ki 10.46 CHEMBL IUPHAR
Somatostatin receptor type 1 GPCR AGONIST Ki 9.54 CHEMBL IUPHAR
Somatostatin receptor type 5 GPCR AGONIST Ki 9.85 CHEMBL IUPHAR
Somatostatin receptor type 3 GPCR AGONIST Ki 10 CHEMBL IUPHAR
Somatostatin receptor type 4 GPCR AGONIST Ki 9.23 CHEMBL IUPHAR
Mu-type opioid receptor GPCR IC50 8.22 CHEMBL
Somatostatin receptor GPCR IC50 9.70 CHEMBL
Somatostatin receptor GPCR IC50 5.89 CHEMBL
Somatostatin receptor type 5 GPCR IC50 9.07 CHEMBL
Somatostatin receptor type 2 GPCR IC50 9.55 CHEMBL
Delta-type opioid receptor GPCR IC50 5.70 CHEMBL
Somatostatin receptor type 3 GPCR IC50 10.10 CHEMBL

External reference:

IDSource
N0000007997 NUI
C0037659 UMLSCUI
D07431 KEGG_DRUG
6E20216Q0L UNII
4311 INN_ID
57819002 SNOMEDCT_US
49722008 SNOMEDCT_US
9939 RXNORM
005072 NDDF
DB09099 DRUGBANK_ID
CHEBI:64628 CHEBI
D013004 MESH_DESCRIPTOR_UI
CHEMBL1823872 ChEMBL_ID
16129706 PUBCHEM_CID
2019 IUPHAR_LIGAND_ID

Pharmaceutical products:

None