DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
lepirudin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
hirudin derivatives
2995
138068-37-8
Description:
Molecule
Description
Synonyms:
lepirudin
refludan
recombinant hirudin
lepirudin recombinant
Molecular weight: 6979.49
Formula: C287H440N80O111S6
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 3107.12
ALOGS:
ROTB: None
Drug dosage:
Dose
Unit
Route
0.25
g
P
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
March 6, 1998
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
B01AE02
BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct thrombin inhibitors
CHEBI has role
CHEBI:50249
anticoagulants
CHEBI has role
CHEBI:65232
thrombin inhibitors
FDA EPC
N0000175518
Direct Thrombin Inhibitor
FDA EPC
N0000175980
Anti-coagulant
FDA MoA
N0000009963
Thrombin Inhibitors
MeSH PA
D000925
Anticoagulants
MeSH PA
D000991
Antithrombins
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D004791
Enzyme Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Thrombosis in Heparin Induced Thrombocytopenia
indication
Arteriovenous malformation
contraindication
24551003
Blood coagulation disorder
contraindication
64779008
DOID:1247
Kidney disease
contraindication
90708001
DOID:557
Procedure on central nervous system
contraindication
118679007
Intracranial aneurysm
contraindication
128609009
DOID:10941
Bleeding
contraindication
131148009
Cerebrovascular accident
contraindication
230690007
Infective endocarditis
contraindication
233850007
Arterial aneurysm
contraindication
233981004
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prothrombin
Enzyme
P00734
THRB_HUMAN
INHIBITOR
Ki
13
IUPHAR
DRUG LABEL
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External reference:
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ID
Source
007520
NDDF
007521
NDDF
108995001
SNOMEDCT_US
11620
MMSL
118856773
PUBCHEM_CID
189643
RXNORM
386955005
SNOMEDCT_US
4021096
VUID
4021096
VANDF
4962
MMSL
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Pharmaceutical products:
None
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lepirudin