lepirudin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
hirudin derivatives 2995 138068-37-8

Description:

MoleculeDescription

Synonyms:

  • lepirudin
  • refludan
  • recombinant hirudin
  • lepirudin recombinant
  • Molecular weight: 6979.49
  • Formula: C287H440N80O111S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 3107.12
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.25 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 6, 1998 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Activated partial thromboplastin time prolonged 59.82 47.59 11 114 6878 46679059
Heparin-induced thrombocytopenia 51.28 47.59 9 116 4300 46681637

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 78.42 54.86 14 99 5369 29946996

Pharmacologic Action:

SourceCodeDescription
ATC B01AE02 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct thrombin inhibitors
FDA MoA N0000009963 Thrombin Inhibitors
FDA EPC N0000175518 Direct Thrombin Inhibitor
MeSH PA D000925 Anticoagulants
MeSH PA D000991 Antithrombins
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D011480 Protease Inhibitors
MeSH PA D015842 Serine Proteinase Inhibitors
FDA EPC N0000175980 Anti-coagulant
CHEBI has role CHEBI:50249 anticoagulante
CHEBI has role CHEBI:65232 ec 3.4.21.5 inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Thrombosis in Heparin Induced Thrombocytopenia indication
Arteriovenous malformation contraindication 24551003
Blood coagulation disorder contraindication 64779008 DOID:1247
Kidney disease contraindication 90708001 DOID:557
Procedure on central nervous system contraindication 118679007
Intracranial aneurysm contraindication 128609009 DOID:10941
Bleeding contraindication 131148009
Cerebrovascular accident contraindication 230690007
Infective endocarditis contraindication 233850007
Arterial aneurysm contraindication 233981004
Disease of liver contraindication 235856003 DOID:409
Surgical procedure contraindication 387713003
Gastric ulcer contraindication 397825006 DOID:10808
Thoracic surgery contraindication 408456005
Hypertensive urgency contraindication 443482000
Uncontrolled Coagulation Defects contraindication
Severe GI Bleeding within Last 10 Days contraindication
Hemorrhagic Diabetic Retinopathy contraindication
Puncture of Noncompressible Artery contraindication
CNS Trauma contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prothrombin Enzyme INHIBITOR Ki 13 IUPHAR DRUG LABEL

External reference:

IDSource
4021096 VUID
N0000148552 NUI
D06880 KEGG_DRUG
4021096 VANDF
C0772394 UMLSCUI
CHEBI:142437 CHEBI
CHEMBL1201666 ChEMBL_ID
DB00001 DRUGBANK_ID
C083544 MESH_SUPPLEMENTAL_RECORD_UI
6469 IUPHAR_LIGAND_ID
7355 INN_ID
Y43GF64R34 UNII
118856773 PUBCHEM_CID
189643 RXNORM
11620 MMSL
4962 MMSL
d04291 MMSL
007520 NDDF
007521 NDDF
108995001 SNOMEDCT_US
386955005 SNOMEDCT_US

Pharmaceutical products:

None