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| Stem definition | Drug id | CAS RN |
|---|---|---|
| hirudin derivatives | 2995 | 138068-37-8 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
| Dose | Unit | Route |
|---|---|---|
| 0.25 | g | P |
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 6, 1998 | FDA |
None
None
None
None
| Source | Code | Description |
|---|---|---|
| ATC | B01AE02 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Direct thrombin inhibitors |
| FDA MoA | N0000009963 | Thrombin Inhibitors |
| FDA EPC | N0000175518 | Direct Thrombin Inhibitor |
| MeSH PA | D000925 | Anticoagulants |
| MeSH PA | D000991 | Antithrombins |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005343 | Fibrinolytic Agents |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D015842 | Serine Proteinase Inhibitors |
| FDA EPC | N0000175980 | Anti-coagulant |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:50249 | anticoagulant |
| CHEBI has role | CHEBI:65232 | EC 3.4.21.5 (thrombin) inhibitor |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Thrombosis in Heparin Induced Thrombocytopenia | indication | ||
| Arteriovenous malformation | contraindication | 24551003 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Procedure on central nervous system | contraindication | 118679007 | |
| Intracranial aneurysm | contraindication | 128609009 | DOID:10941 |
| Bleeding | contraindication | 131148009 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Infective endocarditis | contraindication | 233850007 | |
| Arterial aneurysm | contraindication | 233981004 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Surgical procedure | contraindication | 387713003 | |
| Gastric ulcer | contraindication | 397825006 | DOID:10808 |
| Thoracic surgery | contraindication | 408456005 | |
| Hypertensive urgency | contraindication | 443482000 | |
| Uncontrolled Coagulation Defects | contraindication | ||
| Severe GI Bleeding within Last 10 Days | contraindication | ||
| Hemorrhagic Diabetic Retinopathy | contraindication | ||
| Puncture of Noncompressible Artery | contraindication | ||
| CNS Trauma | contraindication |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prothrombin | Enzyme | INHIBITOR | Ki | 13 | IUPHAR | DRUG LABEL |
| ID | Source |
|---|---|
| 4021096 | VUID |
| N0000148552 | NUI |
| D06880 | KEGG_DRUG |
| 4021096 | VANDF |
| C0772394 | UMLSCUI |
| CHEBI:142437 | CHEBI |
| CHEMBL1201666 | ChEMBL_ID |
| DB00001 | DRUGBANK_ID |
| C083544 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6469 | IUPHAR_LIGAND_ID |
| 7355 | INN_ID |
| Y43GF64R34 | UNII |
| 118856773 | PUBCHEM_CID |
| 189643 | RXNORM |
| 11620 | MMSL |
| 4962 | MMSL |
| d04291 | MMSL |
| 007520 | NDDF |
| 007521 | NDDF |
| 108995001 | SNOMEDCT_US |
| 386955005 | SNOMEDCT_US |
None