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| Stem definition | Drug id | CAS RN |
|---|---|---|
| hirudin derivatives | 2990 | 120993-53-5 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
recombinant hirudin; has identical amino acid sequence as the natural hirudin variant 1 but lacks the sulphate group on Tyr(63)
|
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | P |
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 4, 2003 | FDA | MARATHON PHARMS LLC |
None
None
None
None
| Source | Code | Description |
|---|---|---|
| ATC | B01AE01 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Direct thrombin inhibitors |
| FDA MoA | N0000009963 | Thrombin Inhibitors |
| FDA EPC | N0000175518 | Direct Thrombin Inhibitor |
| MeSH PA | D000925 | Anticoagulants |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D005343 | Fibrinolytic Agents |
| MeSH PA | D006401 | Hematologic Agents |
| FDA EPC | N0000175980 | Anti-coagulant |
| CHEBI has role | CHEBI:50249 | anticoagulant |
| CHEBI has role | CHEBI:65232 | EC 3.4.21.5 (thrombin) inhibitor |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Prevention of deep vein thrombosis | indication | 439993001 | |
| Intracranial hemorrhage | contraindication | 1386000 | |
| Diabetic retinopathy | contraindication | 4855003 | DOID:8947 |
| Retinal hemorrhage | contraindication | 28998008 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Operation on brain | contraindication | 70586009 | |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Pulmonary hemorrhage | contraindication | 78144005 | |
| Hemophilia | contraindication | 90935002 | |
| Procedure on central nervous system | contraindication | 118679007 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Hemorrhagic cerebral infarction | contraindication | 230706003 | |
| Local anesthetic intrathecal block | contraindication | 231249005 | |
| Procedure on spine | contraindication | 238181003 | |
| Lumbar puncture | contraindication | 277762005 | |
| Bacterial endocarditis | contraindication | 301183007 | |
| Surgical procedure | contraindication | 387713003 | |
| Hypertensive urgency | contraindication | 443482000 | |
| Ocular Bleeding | contraindication | ||
| Placement of Epidural Catheter | contraindication | ||
| Significant Bleeding | contraindication |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prothrombin | Enzyme | INHIBITOR | Ki | 12.70 | IUPHAR | DRUG LABEL |
| ID | Source |
|---|---|
| 4032625 | VUID |
| N0000188382 | NUI |
| D03692 | KEGG_DRUG |
| 4032625 | VANDF |
| C0378366 | UMLSCUI |
| CHEBI:140427 | CHEBI |
| CHEMBL1201662 | ChEMBL_ID |
| DB11095 | DRUGBANK_ID |
| C060225 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6458 | IUPHAR_LIGAND_ID |
| 7193 | INN_ID |
| U0JZ726775 | UNII |
| 16129703 | PUBCHEM_CID |
| DB00001 | DRUGBANK_ID |
| 114934 | RXNORM |
| 17230 | MMSL |
| d04865 | MMSL |
| 007722 | NDDF |
| 319718008 | SNOMEDCT_US |
| 407117009 | SNOMEDCT_US |
None