DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
ximelagatran ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
thrombin inhibitors, antithrombotic agents
2852
192939-46-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
H-376/95
H 376/95
ximelagatran
exanta
Molecular weight: 473.57
Formula: C24H35N5O5
CLOGP: 1.77
LIPINSKI: 0
HAC: 10
HDO: 5
TPSA: 143.85
ALOGS: -3.60
ROTB: 11
Drug dosage:
Dose
Unit
Route
6
mg
P
48
mg
O
ADMET properties:
Show
10
25
50
100
entries
Search:
Property
Value
Reference
BA (Bioavailability)
21 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
MRTD (Maximum Recommended Therapeutic Daily Dose)
2.17 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Bocci G, Oprea TI, Benet LZ
Showing 1 to 3 of 3 entries
Previous
1
Next
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
Jan. 1, 2004
YEAR INTRODUCED
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
ATC
B01AE04
BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct thrombin inhibitors
ATC
B01AE05
BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct thrombin inhibitors
CHEBI has role
CHEBI:50249
anticoagulants
CHEBI has role
CHEBI:64926
serine protease inhibitors
CHEBI has role
CHEBI:65232
thrombin inhibitors
CHEBI has role
CHEBI:50266
Prodrugs
MeSH PA
D000925
Anticoagulants
MeSH PA
D000991
Antithrombins
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D006401
Hematologic Agents
Showing 1 to 10 of 12 entries
Previous
1
2
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Prevention of deep vein thrombosis
indication
439993001
Showing 1 to 1 of 1 entries
Previous
1
Next
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.5
acidic
pKa2
13.76
acidic
pKa3
6.65
Basic
pKa4
5.82
Basic
Showing 1 to 4 of 4 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prothrombin
Enzyme
P00734
THRB_HUMAN
INHIBITOR
Ki
6.43
WOMBAT-PK
SCIENTIFIC LITERATURE
Plasminogen
Enzyme
P00747
PLMN_HUMAN
Ki
5.74
CHEMBL
Coagulation factor X
Enzyme
P00742
FA10_HUMAN
Ki
5.43
CHEMBL
Tissue-type plasminogen activator
Enzyme
P00750
TPA_HUMAN
Ki
5.82
CHEMBL
Urokinase-type plasminogen activator
Enzyme
P00749
UROK_HUMAN
Ki
5.20
CHEMBL
Vitamin K-dependent protein C
Enzyme
P04070
PROC_HUMAN
IC50
5.89
CHEMBL
Coagulation factor XI
Enzyme
P03951
FA11_HUMAN
IC50
4.70
CHEMBL
Coagulation factor VII
Enzyme
P08709
FA7_HUMAN
IC50
5.48
CHEMBL
Cationic trypsin
Enzyme
TRY1_BOVIN
IC50
7.95
CHEMBL
Showing 1 to 9 of 9 entries
Previous
1
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
159776-70-2
SECONDARY_CAS_RN
183797
PUBCHEM_CID
2A9QP32MD4
UNII
4025284
VANDF
415853004
SNOMEDCT_US
49HFB70472
UNII
6381
IUPHAR_LIGAND_ID
6382
IUPHAR_LIGAND_ID
7414
INN_ID
8037
INN_ID
Showing 1 to 10 of 22 entries
Previous
1
2
3
Next
Pharmaceutical products:
None
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
ximelagatran