calcitonin (salmon synthetic) 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2989 47931-85-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • calcitonin (salmon)
  • calcitonin (salmon synthetic)
  • calcitonin salmon
  • salmon calcitonin
  • calcitonin salmon recombinant
  • miacalcin
  • calcimar
  • Molecular weight: 3431.90
  • Formula: C145H240N44O48S2
  • CLOGP:
  • LIPINSKI: 3
  • HAC: 92
  • HDO: 52
  • TPSA: 1508.21
  • ALOGS: -4.12
  • ROTB: 98

Drug dosage:

DoseUnitRoute
200 U N
100 U P

ADMET properties:

PropertyValueReference
S (Water solubility) 1 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
April 17, 1978 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hip fracture 63.14 15.54 36 6705 33041 90588665
Femur fracture 52.17 15.54 36 6705 46046 90575660
Neonatal hypocalcaemia 48.91 15.54 7 6734 25 90621681
Product complaint 46.95 15.54 22 6719 13478 90608228
Low turnover osteopathy 43.34 15.54 15 6726 4203 90617503
Spinal compression fracture 41.55 15.54 21 6720 15157 90606549
Rib fracture 40.57 15.54 25 6716 26410 90595296
Coronary artery disease 39.78 15.54 27 6714 33596 90588110
Off label use 38.56 15.54 17 6724 1102235 89519471
Neonatal cholestasis 37.33 15.54 6 6735 53 90621653
Stress fracture 36.15 15.54 16 6725 8595 90613111
Bone density decreased 36.14 15.54 20 6721 17325 90604381
Compression fracture 35.83 15.54 16 6725 8773 90612933
Nasal discomfort 32.28 15.54 13 6728 5535 90616171
Foot fracture 30.61 15.54 21 6720 26585 90595121
Fall 29.87 15.54 91 6650 481719 90139987
Body height decreased 28.29 15.54 15 6726 11934 90609772
Blood calcium increased 28.17 15.54 15 6726 12043 90609663
Foetal heart rate deceleration abnormality 27.58 15.54 7 6734 672 90621034
Fracture 26.76 15.54 18 6723 22058 90599648
Thoracic vertebral fracture 25.68 15.54 11 6730 5463 90616243
Back pain 25.62 15.54 66 6675 317109 90304597
Cerebrovascular accident 25.20 15.54 38 6703 123495 90498211
Hypercalcaemia 23.79 15.54 20 6721 34220 90587486
Osteopenia 23.76 15.54 17 6724 22985 90598721
Intramedullary rod insertion 23.39 15.54 8 6733 2164 90619542
Device failure 23.24 15.54 11 6730 6886 90614820
Product odour abnormal 21.77 15.54 7 6734 1564 90620142
Transient ischaemic attack 21.67 15.54 21 6720 43155 90578551
Dementia Alzheimer's type 20.41 15.54 6 6735 995 90620711
Jaundice neonatal 20.36 15.54 6 6735 1004 90620702
Pelvic fracture 19.88 15.54 13 6728 15206 90606500
Open reduction of fracture 19.53 15.54 6 6735 1156 90620550
Anaemia postoperative 19.42 15.54 7 6734 2206 90619500
Hyperlipidaemia 19.34 15.54 15 6726 22901 90598805
Bone disorder 19.22 15.54 15 6726 23105 90598601
Urinary tract infection 19.15 15.54 58 6683 305574 90316132
Diverticulum 17.43 15.54 11 6730 12102 90609604
Osteoporosis 17.32 15.54 28 6713 96503 90525203
Chronic obstructive pulmonary disease 16.91 15.54 24 6717 73805 90547901
Cardiac failure congestive 16.86 15.54 28 6713 98666 90523040
Osteomalacia 16.66 15.54 5 6736 890 90620816
Lumbar vertebral fracture 16.64 15.54 9 6732 7449 90614257
Nocturia 16.50 15.54 10 6731 10245 90611461
Intervertebral disc degeneration 16.11 15.54 12 6729 17262 90604444
Gastrooesophageal reflux disease 15.95 15.54 37 6704 166300 90455406

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory tract infection bacterial 104.36 26.69 20 882 1889 42618544
Respiratory tract infection viral 98.48 26.69 21 881 3385 42617048
Respiratory tract infection 59.69 26.69 22 880 26300 42594133

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory tract infection bacterial 83.54 15.64 20 5186 2396 110581697
Respiratory tract infection viral 70.23 15.64 21 5185 5857 110578236
Hip fracture 67.51 15.64 33 5173 35118 110548975
Product complaint 52.43 15.64 21 5185 13951 110570142
Spinal compression fracture 37.51 15.64 18 5188 18374 110565719
Compression fracture 31.54 15.64 13 5193 9286 110574807
Bone density decreased 30.61 15.64 15 5191 16027 110568066
Thoracic vertebral fracture 28.47 15.64 11 5195 6644 110577449
Femur fracture 27.26 15.64 20 5186 44449 110539644
Respiratory tract infection 26.52 15.64 24 5182 71593 110512500
Stress fracture 24.17 15.64 10 5196 7211 110576882
Low turnover osteopathy 23.19 15.64 7 5199 2015 110582078
Fall 22.62 15.64 71 5135 603411 109980682
Fracture 19.52 15.64 13 5193 24775 110559318
Back pain 19.11 15.64 49 5157 370947 110213146
Osteoporosis 19.08 15.64 22 5184 87130 110496963
Coronary artery disease 18.99 15.64 20 5186 71670 110512423
Bone disorder 18.86 15.64 12 5194 21180 110562913
Lumbar vertebral fracture 18.81 15.64 9 5197 9122 110574971
Blood calcium increased 18.03 15.64 11 5195 18029 110566064
Pelvic fracture 17.76 15.64 10 5196 14144 110569949
Off label use 16.89 15.64 28 5178 1500157 109083936
Cerebrovascular accident 16.29 15.64 30 5176 181254 110402839
Product odour abnormal 16.11 15.64 5 5201 1578 110582515
Osteomalacia 16.10 15.64 5 5201 1582 110582511
Rib fracture 15.92 15.64 13 5193 33757 110550336

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H05BA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
ANTI-PARATHYROID AGENTS
Calcitonin preparations
FDA CS M0003145 Calcitonin
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D050071 Bone Density Conservation Agents
FDA EPC N0000175942 Calcitonin
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:50646 antiosteoporotic

Related Drugs by ATC class:

H05BA Calcitonin preparations 3 drugs
calcitonin humancalcitonin (pork natural)elcatonin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Postmenopausal osteoporosis indication 102447009
Hypercalcemia Treatment Adjunct indication
Osteogenesis imperfecta off-label use 78314001 DOID:12347
Secondary generalized osteoporosis off-label use 240157009
Hypocalcemia contraindication 5291005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.97 acidic
pKa2 9.82 acidic
pKa3 11.87 acidic
pKa4 11.89 acidic
pKa5 12.24 acidic
pKa6 12.48 acidic
pKa7 12.51 acidic
pKa8 12.78 acidic
pKa9 12.85 acidic
pKa10 13.1 acidic
pKa11 13.1 acidic
pKa12 13.14 acidic
pKa13 13.34 acidic
pKa14 13.39 acidic
pKa15 13.5 acidic
pKa16 13.56 acidic
pKa17 13.68 acidic
pKa18 13.74 acidic
pKa19 13.76 acidic
pKa20 13.91 acidic
pKa21 13.96 acidic
pKa22 11.25 Basic
pKa23 10.81 Basic
pKa24 10.31 Basic
pKa25 7.22 Basic
pKa26 6.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Calcitonin receptor GPCR AGONIST EC50 11.09 SCIENTIFIC LITERATURE DRUG LABEL
Amylin receptor AMY1 GPCR AGONIST IC50 9.65 SCIENTIFIC LITERATURE
Amylin receptor AMY2 GPCR AGONIST IC50 9.87 SCIENTIFIC LITERATURE
Amylin receptor AMY3 GPCR AGONIST IC50 9.50 SCIENTIFIC LITERATURE

External reference:

IDSource
4018748 VUID
N0000179235 NUI
D00249 KEGG_DRUG
4018748 VANDF
C0073994 UMLSCUI
CHEMBL3989767 ChEMBL_ID
DB00017 DRUGBANK_ID
C028815 MESH_SUPPLEMENTAL_RECORD_UI
16133812 PUBCHEM_CID
218351 RXNORM
1074 MMSL
1124 MMSL
4323 MMSL
6069 MMSL
002144 NDDF
127384006 SNOMEDCT_US
325936007 SNOMEDCT_US
713394005 SNOMEDCT_US
CHEBI:3306 CHEBI
6973 IUPHAR_LIGAND_ID
7SFC6U2VI5 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcitonin Salmon HUMAN PRESCRIPTION DRUG LABEL 1 24201-400 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR ANDA 26 sections
Calcitonin Salmon HUMAN PRESCRIPTION DRUG LABEL 1 25021-473 INJECTION, SOLUTION 400 [USPU] INTRAMUSCULAR ANDA 27 sections
Calcitonin Salmon HUMAN PRESCRIPTION DRUG LABEL 1 42023-205 INJECTION, SOLUTION 200 [iU] INTRAMUSCULAR ANDA 26 sections
Calcitonin Salmon HUMAN PRESCRIPTION DRUG LABEL 1 43598-051 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR ANDA 25 sections
CALCITONIN SALMON HUMAN PRESCRIPTION DRUG LABEL 1 49884-161 SPRAY, METERED 200 [iU] NASAL ANDA 25 sections
Fortical HUMAN PRESCRIPTION DRUG LABEL 1 54868-5499 SPRAY, METERED 2200 [iU] NASAL NDA 24 sections
CALCITONIN SALMON HUMAN PRESCRIPTION DRUG LABEL 1 54868-6323 SPRAY, METERED 200 [iU] NASAL ANDA 20 sections
Calcitonin Salmon HUMAN PRESCRIPTION DRUG LABEL 1 60505-0823 SPRAY, METERED 200 [iU] NASAL ANDA 26 sections
Calcitonin Salmon HUMAN PRESCRIPTION DRUG LABEL 1 63323-865 INJECTION, SOLUTION 200 [iU] INTRAMUSCULAR ANDA 26 sections
Miacalcin HUMAN PRESCRIPTION DRUG LABEL 1 67457-675 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR NDA 26 sections
CALCITONIN SALMON HUMAN PRESCRIPTION DRUG LABEL 1 69097-770 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR ANDA 20 sections
calcitonin salmon HUMAN PRESCRIPTION DRUG LABEL 1 70121-1650 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR ANDA 25 sections
CALCITONIN SALMON HUMAN PRESCRIPTION DRUG LABEL 1 70710-1875 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR ANDA 24 sections
CALCITONIN SALMON HUMAN PRESCRIPTION DRUG LABEL 1 70771-1971 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR ANDA 2 sections
Miacalcin HUMAN PRESCRIPTION DRUG LABEL 1 72078-038 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR NDA 26 sections
Miacalcin HUMAN PRESCRIPTION DRUG LABEL 1 72078-039 INJECTION, SOLUTION 200 [USPU] INTRAMUSCULAR NDA 26 sections