calcitonin (salmon synthetic)

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Dose	Unit	Route
200	U	N
100	U	P

Property	Value	Reference
S (Water solubility)	1 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hip fracture	63.14	15.54	36	6705	33041	90588665
Femur fracture	52.17	15.54	36	6705	46046	90575660
Neonatal hypocalcaemia	48.91	15.54	7	6734	25	90621681
Product complaint	46.95	15.54	22	6719	13478	90608228
Low turnover osteopathy	43.34	15.54	15	6726	4203	90617503
Spinal compression fracture	41.55	15.54	21	6720	15157	90606549
Rib fracture	40.57	15.54	25	6716	26410	90595296
Coronary artery disease	39.78	15.54	27	6714	33596	90588110
Off label use	38.56	15.54	17	6724	1102235	89519471
Neonatal cholestasis	37.33	15.54	6	6735	53	90621653
Stress fracture	36.15	15.54	16	6725	8595	90613111
Bone density decreased	36.14	15.54	20	6721	17325	90604381
Compression fracture	35.83	15.54	16	6725	8773	90612933
Nasal discomfort	32.28	15.54	13	6728	5535	90616171
Foot fracture	30.61	15.54	21	6720	26585	90595121
Fall	29.87	15.54	91	6650	481719	90139987
Body height decreased	28.29	15.54	15	6726	11934	90609772
Blood calcium increased	28.17	15.54	15	6726	12043	90609663
Foetal heart rate deceleration abnormality	27.58	15.54	7	6734	672	90621034
Fracture	26.76	15.54	18	6723	22058	90599648
Thoracic vertebral fracture	25.68	15.54	11	6730	5463	90616243
Back pain	25.62	15.54	66	6675	317109	90304597
Cerebrovascular accident	25.20	15.54	38	6703	123495	90498211
Hypercalcaemia	23.79	15.54	20	6721	34220	90587486
Osteopenia	23.76	15.54	17	6724	22985	90598721
Intramedullary rod insertion	23.39	15.54	8	6733	2164	90619542
Device failure	23.24	15.54	11	6730	6886	90614820
Product odour abnormal	21.77	15.54	7	6734	1564	90620142
Transient ischaemic attack	21.67	15.54	21	6720	43155	90578551
Dementia Alzheimer's type	20.41	15.54	6	6735	995	90620711
Jaundice neonatal	20.36	15.54	6	6735	1004	90620702
Pelvic fracture	19.88	15.54	13	6728	15206	90606500
Open reduction of fracture	19.53	15.54	6	6735	1156	90620550
Anaemia postoperative	19.42	15.54	7	6734	2206	90619500
Hyperlipidaemia	19.34	15.54	15	6726	22901	90598805
Bone disorder	19.22	15.54	15	6726	23105	90598601
Urinary tract infection	19.15	15.54	58	6683	305574	90316132
Diverticulum	17.43	15.54	11	6730	12102	90609604
Osteoporosis	17.32	15.54	28	6713	96503	90525203
Chronic obstructive pulmonary disease	16.91	15.54	24	6717	73805	90547901
Cardiac failure congestive	16.86	15.54	28	6713	98666	90523040
Osteomalacia	16.66	15.54	5	6736	890	90620816
Lumbar vertebral fracture	16.64	15.54	9	6732	7449	90614257
Nocturia	16.50	15.54	10	6731	10245	90611461
Intervertebral disc degeneration	16.11	15.54	12	6729	17262	90604444
Gastrooesophageal reflux disease	15.95	15.54	37	6704	166300	90455406

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	104.36	26.69	20	882	1889	42618544
Respiratory tract infection viral	98.48	26.69	21	881	3385	42617048
Respiratory tract infection	59.69	26.69	22	880	26300	42594133

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	83.54	15.64	20	5186	2396	110581697
Respiratory tract infection viral	70.23	15.64	21	5185	5857	110578236
Hip fracture	67.51	15.64	33	5173	35118	110548975
Product complaint	52.43	15.64	21	5185	13951	110570142
Spinal compression fracture	37.51	15.64	18	5188	18374	110565719
Compression fracture	31.54	15.64	13	5193	9286	110574807
Bone density decreased	30.61	15.64	15	5191	16027	110568066
Thoracic vertebral fracture	28.47	15.64	11	5195	6644	110577449
Femur fracture	27.26	15.64	20	5186	44449	110539644
Respiratory tract infection	26.52	15.64	24	5182	71593	110512500
Stress fracture	24.17	15.64	10	5196	7211	110576882
Low turnover osteopathy	23.19	15.64	7	5199	2015	110582078
Fall	22.62	15.64	71	5135	603411	109980682
Fracture	19.52	15.64	13	5193	24775	110559318
Back pain	19.11	15.64	49	5157	370947	110213146
Osteoporosis	19.08	15.64	22	5184	87130	110496963
Coronary artery disease	18.99	15.64	20	5186	71670	110512423
Bone disorder	18.86	15.64	12	5194	21180	110562913
Lumbar vertebral fracture	18.81	15.64	9	5197	9122	110574971
Blood calcium increased	18.03	15.64	11	5195	18029	110566064
Pelvic fracture	17.76	15.64	10	5196	14144	110569949
Off label use	16.89	15.64	28	5178	1500157	109083936
Cerebrovascular accident	16.29	15.64	30	5176	181254	110402839
Product odour abnormal	16.11	15.64	5	5201	1578	110582515
Osteomalacia	16.10	15.64	5	5201	1582	110582511
Rib fracture	15.92	15.64	13	5193	33757	110550336

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calcitonin (salmon synthetic) 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products:

Source	Code	Description
ATC	H05BA01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CALCIUM HOMEOSTASIS ANTI-PARATHYROID AGENTS Calcitonin preparations
FDA CS	M0003145	Calcitonin
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D050071	Bone Density Conservation Agents
FDA EPC	N0000175942	Calcitonin
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:50646	antiosteoporotic

Disease	Relation	SNOMED_ID	DOID
Osteitis deformans	indication	2089002	DOID:5408
Postmenopausal osteoporosis	indication	102447009
Hypercalcemia Treatment Adjunct	indication
Osteogenesis imperfecta	off-label use	78314001	DOID:12347
Secondary generalized osteoporosis	off-label use	240157009
Hypocalcemia	contraindication	5291005

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.97	acidic
pKa2	9.82	acidic
pKa3	11.87	acidic
pKa4	11.89	acidic
pKa5	12.24	acidic
pKa6	12.48	acidic
pKa7	12.51	acidic
pKa8	12.78	acidic
pKa9	12.85	acidic
pKa10	13.1	acidic
pKa11	13.1	acidic
pKa12	13.14	acidic
pKa13	13.34	acidic
pKa14	13.39	acidic
pKa15	13.5	acidic
pKa16	13.56	acidic
pKa17	13.68	acidic
pKa18	13.74	acidic
pKa19	13.76	acidic
pKa20	13.91	acidic
pKa21	13.96	acidic
pKa22	11.25	Basic
pKa23	10.81	Basic
pKa24	10.31	Basic
pKa25	7.22	Basic
pKa26	6.54	Basic

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Calcitonin receptor	GPCR	P30988	CALCR_HUMAN	AGONIST	EC50	11.09	SCIENTIFIC LITERATURE	DRUG LABEL
Amylin receptor AMY1	GPCR	P30988 O60894	CALCR_HUMAN RAMP1_HUMAN	AGONIST	IC50	9.65	SCIENTIFIC LITERATURE
Amylin receptor AMY2	GPCR	P30988 O60895	CALCR_HUMAN RAMP2_HUMAN	AGONIST	IC50	9.87	SCIENTIFIC LITERATURE
Amylin receptor AMY3	GPCR	P30988 O60896	CALCR_HUMAN RAMP3_HUMAN	AGONIST	IC50	9.50	SCIENTIFIC LITERATURE

ID	Source
4018748	VUID
N0000179235	NUI
D00249	KEGG_DRUG
4018748	VANDF
C0073994	UMLSCUI
CHEMBL3989767	ChEMBL_ID
DB00017	DRUGBANK_ID
C028815	MESH_SUPPLEMENTAL_RECORD_UI
16133812	PUBCHEM_CID
218351	RXNORM
1074	MMSL
1124	MMSL
4323	MMSL
6069	MMSL
002144	NDDF
127384006	SNOMEDCT_US
325936007	SNOMEDCT_US
713394005	SNOMEDCT_US
CHEBI:3306	CHEBI
6973	IUPHAR_LIGAND_ID
7SFC6U2VI5	UNII

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Calcitonin Salmon	HUMAN PRESCRIPTION DRUG LABEL	1	24201-400	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	ANDA	26 sections
Calcitonin Salmon	HUMAN PRESCRIPTION DRUG LABEL	1	25021-473	INJECTION, SOLUTION	400 [USPU]	INTRAMUSCULAR	ANDA	27 sections
Calcitonin Salmon	HUMAN PRESCRIPTION DRUG LABEL	1	42023-205	INJECTION, SOLUTION	200 [iU]	INTRAMUSCULAR	ANDA	26 sections
Calcitonin Salmon	HUMAN PRESCRIPTION DRUG LABEL	1	43598-051	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	ANDA	25 sections
CALCITONIN SALMON	HUMAN PRESCRIPTION DRUG LABEL	1	49884-161	SPRAY, METERED	200 [iU]	NASAL	ANDA	25 sections
Fortical	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5499	SPRAY, METERED	2200 [iU]	NASAL	NDA	24 sections
CALCITONIN SALMON	HUMAN PRESCRIPTION DRUG LABEL	1	54868-6323	SPRAY, METERED	200 [iU]	NASAL	ANDA	20 sections
Calcitonin Salmon	HUMAN PRESCRIPTION DRUG LABEL	1	60505-0823	SPRAY, METERED	200 [iU]	NASAL	ANDA	26 sections
Calcitonin Salmon	HUMAN PRESCRIPTION DRUG LABEL	1	63323-865	INJECTION, SOLUTION	200 [iU]	INTRAMUSCULAR	ANDA	26 sections
Miacalcin	HUMAN PRESCRIPTION DRUG LABEL	1	67457-675	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	NDA	26 sections
CALCITONIN SALMON	HUMAN PRESCRIPTION DRUG LABEL	1	69097-770	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	ANDA	20 sections
calcitonin salmon	HUMAN PRESCRIPTION DRUG LABEL	1	70121-1650	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	ANDA	25 sections
CALCITONIN SALMON	HUMAN PRESCRIPTION DRUG LABEL	1	70710-1875	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	ANDA	24 sections
CALCITONIN SALMON	HUMAN PRESCRIPTION DRUG LABEL	1	70771-1971	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	ANDA	2 sections
Miacalcin	HUMAN PRESCRIPTION DRUG LABEL	1	72078-038	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	NDA	26 sections
Miacalcin	HUMAN PRESCRIPTION DRUG LABEL	1	72078-039	INJECTION, SOLUTION	200 [USPU]	INTRAMUSCULAR	NDA	26 sections