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doxacurium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| neuromuscular blocking agents with rigid structure | 2974 | 133814-18-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
according to Unlisted Drugs, BW-A938U is a bis-benzylisoquinolinium diester and a highly potent neuromuscular blocker
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.05 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.53 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.70 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.00 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -0.561 | Moderate | 0.73 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 12.106 | Moderate | 0.73 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.703 | 10^-6 cm/s | Moderate | 0.73 |
| dh-clint | Dog hepatocyte intrinsic clearance | 5.140 | uL/min/10^6 cells | Moderate | 0.73 |
| dppb | Dog plasma protein binding (% unbound) | 42.400 | % | Moderate | 0.73 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 62.510 | % | Moderate | 0.73 |
| herg | hERG pIC50 | 4.419 | pIC50 | Moderate | 0.73 |
| hh-clint | Human hepatocyte intrinsic clearance | 3.436 | uL/min/10^6 cells | Moderate | 0.73 |
| hlm-clint | Human liver microsomal intrinsic clearance | 58.210 | uL/min/mg protein | Moderate | 0.73 |
| hppb | Human plasma protein binding (% unbound) | 29.570 | % | Moderate | 0.73 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.213 | Moderate | 0.73 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 22.491 | Moderate | 0.73 | |
| mppb | Mouse plasma protein binding (% unbound) | 46.490 | Moderate | 0.73 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 3.767 | Moderate | 0.73 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 78.950 | % | Moderate | 0.73 |
| rh-clint | Rat hepatocyte intrinsic clearance | 18.707 | uL/min/10^6 cells | Moderate | 0.73 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 76.520 | % | Moderate | 0.73 |
| rppb | Rat plasma protein binding (% unbound) | 60.050 | % | Moderate | 0.73 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 859.014 | uM | Moderate | 0.73 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 7, 1991 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M03AC07 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS Other quaternary ammonium compounds |
| MeSH PA | D003473 | Neuromuscular Nondepolarizing Agents |
| MeSH PA | D009465 | Neuromuscular Agents |
| MeSH PA | D009466 | Neuromuscular Blocking Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| CHEBI has role | CHEBI:51371 | muscle relaxant |
Related Drugs by ATC class:
M03AC Other quaternary ammonium compounds 10 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Muscle relaxation, function | indication | 11977004 | |
| General anesthesia | indication | 50697003 | |
| Skeletal Muscle Relaxation for Endotracheal Intubation | indication | ||
| Disorder of acid-base balance | contraindication | 26436007 | |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Disorder of electrolytes | contraindication | 237840007 | |
| Renal Impairment associated with Kidney Transplant | contraindication | ||
| Hepatic Impairment associated with Hepatic Transplant | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholine receptor | Ion channel | ANTAGONIST | WOMBAT-PK | CHEMBL | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | WOMBAT-PK | |||||||
| Neuronal acetylcholine receptor subunit alpha-2 | Ion channel | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4020524 | VUID |
| N0000148242 | NUI |
| D00760 | KEGG_DRUG |
| 106791-39-3 | SECONDARY_CAS_RN |
| 83348-52-1 | SECONDARY_CAS_RN |
| 4020136 | VANDF |
| 4020524 | VANDF |
| C0058716 | UMLSCUI |
| CHEBI:4706 | CHEBI |
| CHEMBL1237123 | ChEMBL_ID |
| CHEMBL1237099 | ChEMBL_ID |
| DB01135 | DRUGBANK_ID |
| C049429 | MESH_SUPPLEMENTAL_RECORD_UI |
| P40015Y3WW | UNII |
| 60169 | PUBCHEM_CID |
| 23651 | RXNORM |
| 4635 | MMSL |
| d00957 | MMSL |
| 003582 | NDDF |
| 013424 | NDDF |
| 108458009 | SNOMEDCT_US |
| 108459001 | SNOMEDCT_US |
| 372496007 | SNOMEDCT_US |
| 6205 | INN_ID |
Pharmaceutical products:
None