hexafluronium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1365 317-52-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hexafluorenium bromide
  • hexafluronium
  • hexafluorenium dibromide
  • hexafluronium bromide
curarimimetic agent for use with succinylcholine; muscle relaxant; structure; RN given refers to parent cpd
  • Molecular weight: 502.75
  • Formula: C36H42N2
  • CLOGP: -1.19
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA:
  • ALOGS: -9.44
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA MEDPOINTE PHARM HLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AC05 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018733 Nicotinic Antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme INHIBITOR CHEMBL CHEMBL
Butyrylcholinesterase Enzyme Ki 6.47 CHEMBL
Acetylcholinesterase Enzyme Ki 5.89 CHEMBL

External reference:

IDSource
4018444 VUID
N0000146768 NUI
D04435 KEGG_DRUG
4018444 VANDF
4019775 VANDF
C0129478 UMLSCUI
CHEBI:135804 CHEBI
CHEMBL1200933 ChEMBL_ID
CHEMBL1201349 ChEMBL_ID
DB00941 DRUGBANK_ID
C005034 MESH_SUPPLEMENTAL_RECORD_UI
1143 INN_ID
B64NJG83K2 UNII
9434 PUBCHEM_CID
26826 RXNORM
001713 NDDF
004690 NDDF
19978007 SNOMEDCT_US

Pharmaceutical products:

None