hexafluronium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 1365 317-52-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hexafluorenium bromide
  • hexafluronium
  • hexafluorenium dibromide
  • hexafluronium bromide
curarimimetic agent for use with succinylcholine; muscle relaxant; structure; RN given refers to parent cpd
  • Molecular weight: 502.75
  • Formula: C36H42N2
  • CLOGP: -1.19
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA:
  • ALOGS: -9.44
  • ROTB: 9
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 46
kinase-selectivity-class AXL,BRAF,GRK2 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA MEDPOINTE PHARM HLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AC05 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018733 Nicotinic Antagonists

Related Drugs by ATC class:

M03AC Other quaternary ammonium compounds 10 drugs
atracuriumcisatracuriumdoxacuriumfazadiniumgallaminemivacuriumpancuroniumpipecuroniumrocuroniumvecuronium

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Acetylcholinesterase Enzyme INHIBITOR CHEMBL CHEMBL
Acetylcholinesterase Enzyme Ki 5.89 CHEMBL
Butyrylcholinesterase Enzyme Ki 6.47 CHEMBL

External reference:

IDSource
4018444 VUID
N0000146768 NUI
D04435 KEGG_DRUG
4018444 VANDF
4019775 VANDF
CHEBI:135804 CHEBI
CHEMBL1201349 ChEMBL_ID
CHEMBL1200933 ChEMBL_ID
C005034 MESH_SUPPLEMENTAL_RECORD_UI
DB00941 DRUGBANK_ID
26826 RXNORM
001713 NDDF
004690 NDDF
19978007 SNOMEDCT_US
C0062619 UMLSCUI
3601 PUBCHEM_CID
1143 INN_ID
B64NJG83K2 UNII
B64NJG83K2 INXIGHT DRUGS

Pharmaceutical products:

None