rocuronium ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 2396 119302-91-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ORG-9426
  • ORG 9426
  • rocuronium
  • rocuronium bromide
  • zemuron
  • esmeron
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
  • Molecular weight: 529.79
  • Formula: C32H53N2O4
  • CLOGP: 2.23
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 1
  • TPSA: 59
  • ALOGS: -7.30
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 17 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.54 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 17, 1994 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 1365.75 28.97 469 8724 53586 50542345
Anaphylactic shock 950.95 28.97 282 8911 19873 50576058
Cardiac arrest 420.89 28.97 233 8960 83418 50512513
Hypotension 404.07 28.97 336 8857 235133 50360798
Neuromuscular block prolonged 400.78 28.97 71 9122 440 50595491
Bronchospasm 381.21 28.97 131 9062 14723 50581208
Circulatory collapse 238.98 28.97 101 9092 19899 50576032
Serotonin syndrome 234.20 28.97 106 9087 24607 50571324
Delayed recovery from anaesthesia 204.74 28.97 43 9150 706 50595225
Tachycardia 188.22 28.97 151 9042 99612 50496319
Stress cardiomyopathy 184.61 28.97 65 9128 7822 50588109
Bradycardia 150.95 28.97 111 9082 64315 50531616
Drug interaction 149.03 28.97 182 9011 199439 50396492
Therapeutic product effect prolonged 121.17 28.97 24 9169 289 50595642
Myoglobin urine present 115.91 28.97 24 9169 366 50595565
Recurrence of neuromuscular blockade 112.58 28.97 19 9174 84 50595847
Hypoventilation 106 28.97 36 9157 3885 50592046
Wrist surgery 103.93 28.97 25 9168 773 50595158
Finger deformity 100.13 28.97 38 9155 5644 50590287
Unwanted awareness during anaesthesia 99.21 28.97 20 9173 265 50595666
Airway peak pressure increased 98.52 28.97 20 9173 275 50595656
Ventricular tachycardia 90.13 28.97 48 9145 15773 50580158
Neuromuscular blockade 87.08 28.97 18 9175 272 50595659
Fatigue 86.49 28.97 13 9180 707588 49888343
Pulseless electrical activity 83.14 28.97 35 9158 6806 50589125
Urticaria 82.01 28.97 109 9084 129452 50466479
Breast cancer recurrent 80.07 28.97 29 9164 3779 50592152
Blood pressure decreased 79.38 28.97 72 9121 55837 50540094
Paralysis 78.32 28.97 36 9157 8628 50587303
Oxygen saturation decreased 75.26 28.97 79 9114 73169 50522762
Tenosynovitis 74.47 28.97 37 9156 10528 50585403
Limb operation 68.43 28.97 25 9168 3339 50592592
Amylase increased 63.38 28.97 27 9166 5403 50590528
Diarrhoea 60.97 28.97 16 9177 588460 50007471
Anaphylactoid reaction 60.80 28.97 23 9170 3383 50592548
Hyperthermia malignant 60.64 28.97 16 9177 723 50595208
Ventricular fibrillation 60.03 28.97 32 9161 10527 50585404
Toxic encephalopathy 59.70 28.97 26 9167 5489 50590442
Arthralgia 58.47 28.97 6 9187 438696 50157235
Hypoxia 57.66 28.97 58 9135 51065 50544866
Apnoea 56.93 28.97 27 9166 6939 50588992
Dystonia 56.38 28.97 32 9161 11894 50584037
Anaesthetic complication 55.19 28.97 18 9175 1712 50594219
Nausea 55.11 28.97 30 9163 705368 49890563
Headache 53.92 28.97 13 9180 506522 50089409
Haemodynamic instability 53.31 28.97 27 9166 7997 50587934
Type I hypersensitivity 53.29 28.97 19 9174 2366 50593565
Anaphylactoid shock 52.10 28.97 12 9181 306 50595625
Premature delivery 51.37 28.97 39 9154 23624 50572307
Maternal exposure during delivery 51.31 28.97 15 9178 991 50594940
Troponin increased 50.12 28.97 26 9167 8092 50587839
Procedural hypotension 49.96 28.97 15 9178 1087 50594844
Exposure during pregnancy 49.46 28.97 83 9110 120932 50474999
Endotracheal intubation complication 49.27 28.97 12 9181 391 50595540
Postoperative delirium 47.82 28.97 9 9184 81 50595850
Subcutaneous emphysema 46.28 28.97 13 9180 744 50595187
Airway complication of anaesthesia 45.69 28.97 10 9183 201 50595730
Hyperreflexia 45.42 28.97 21 9172 5097 50590834
Skin test positive 43.49 28.97 12 9181 643 50595288
Angioedema 42.94 28.97 43 9150 37633 50558298
Diabetes insipidus 42.33 28.97 16 9177 2348 50593583
Vasoplegia syndrome 41.33 28.97 13 9180 1101 50594830
Fall 41.11 28.97 6 9187 334926 50261005
Muscle rigidity 40.17 28.97 24 9169 9805 50586126
Blood lactate dehydrogenase increased 39.74 28.97 31 9162 19531 50576400
Tracheal injury 39.54 28.97 7 9186 43 50595888
Laryngeal oedema 39.51 28.97 19 9174 5034 50590897
Respiratory acidosis 39.21 28.97 20 9173 6008 50589923
Clonus 36.64 28.97 17 9176 4158 50591773
Torsade de pointes 36.08 28.97 24 9169 11811 50584120
Anticholinergic syndrome 35.25 28.97 13 9180 1782 50594149
Myasthenic syndrome 35.12 28.97 8 9185 194 50595737
Atrioventricular dissociation 34.22 28.97 8 9185 218 50595713
Vomiting 33.88 28.97 21 9172 460737 50135194
Pulmonary oedema 33.73 28.97 43 9150 48895 50547036
Altered state of consciousness 32.61 28.97 29 9164 21881 50574050
Post procedural stroke 31.78 28.97 6 9187 55 50595876
Cardiac output decreased 31.30 28.97 10 9183 890 50595041
Coronary artery embolism 30.56 28.97 7 9186 174 50595757
Muscle twitching 30.36 28.97 24 9169 15407 50580524
Laryngospasm 30.16 28.97 13 9180 2675 50593256
Therapeutic product effect increased 30.11 28.97 10 9183 1006 50594925
Blood creatine phosphokinase increased 29.87 28.97 30 9163 26337 50569594
Spirometry abnormal 29.43 28.97 7 9186 206 50595725
Blood potassium increased 29.08 28.97 24 9169 16374 50579557

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 730.06 23.76 232 8151 13104 29553040
Anaphylactic reaction 655.77 23.76 258 8125 27315 29538829
Hyperthermia malignant 377.33 23.76 90 8293 1694 29564450
Neuromuscular block prolonged 313.99 23.76 61 8322 402 29565742
Hypotension 233.38 23.76 280 8103 194074 29372070
Bronchospasm 183.37 23.76 77 8306 9532 29556612
Cardiac arrest 180.65 23.76 167 8216 85424 29480720
Recurrence of neuromuscular blockade 162.74 23.76 29 8354 109 29566035
Bradycardia 142.10 23.76 130 8253 65499 29500645
Delayed recovery from anaesthesia 134.96 23.76 33 8350 690 29565454
Pulseless electrical activity 101.20 23.76 45 8338 6389 29559755
Kounis syndrome 100.50 23.76 32 8351 1797 29564347
Negative pressure pulmonary oedema 95.23 23.76 20 8363 203 29565941
Tachycardia 92.32 23.76 108 8275 72302 29493842
Neuromuscular blockade 91.46 23.76 19 8364 182 29565962
Respiratory depression 90.19 23.76 53 8330 13470 29552674
Electrocardiogram ST segment elevation 85.66 23.76 36 8347 4456 29561688
Anaesthetic complication 83.18 23.76 24 8359 962 29565182
Blood pressure decreased 81.04 23.76 81 8302 45396 29520748
Haemodynamic instability 76.82 23.76 40 8343 8033 29558111
Arteriospasm coronary 75.00 23.76 28 8355 2537 29563607
Hypoventilation 68.68 23.76 27 8356 2814 29563330
Fatigue 67.99 23.76 6 8377 316815 29249329
Procedural hypotension 67.74 23.76 20 8363 870 29565274
Oxygen saturation decreased 67.41 23.76 73 8310 44864 29521280
Airway complication of anaesthesia 67.12 23.76 14 8369 137 29566007
Endotracheal intubation complication 61.13 23.76 15 8368 318 29565826
Circulatory collapse 61.03 23.76 47 8336 18626 29547518
Serotonin syndrome 57.06 23.76 44 8339 17468 29548676
Ventricular fibrillation 56.50 23.76 42 8341 15791 29550353
Respiratory arrest 55.42 23.76 51 8332 25782 29540362
Ventricular tachycardia 55.23 23.76 48 8335 22526 29543618
Hypoxia 51.09 23.76 65 8318 47314 29518830
Airway peak pressure increased 47.63 23.76 8 8375 19 29566125
Pulmonary alveolar haemorrhage 45.15 23.76 26 8357 6354 29559790
Unwanted awareness during anaesthesia 44.49 23.76 8 8375 32 29566112
Rhabdomyolysis 44.11 23.76 69 8314 60739 29505405
Respiratory acidosis 42.76 23.76 22 8361 4306 29561838
Intensive care unit acquired weakness 41.70 23.76 14 8369 929 29565215
Death 41.20 23.76 23 8360 342061 29224083
Burkholderia test positive 40.91 23.76 14 8369 985 29565159
Brain oedema 40.45 23.76 31 8352 12189 29553955
Hypoxic-ischaemic encephalopathy 40.10 23.76 21 8362 4263 29561881
Cardio-respiratory arrest 38.91 23.76 59 8324 50542 29515602
Urticaria 38.22 23.76 61 8322 54599 29511545
Pulmonary oedema 37.44 23.76 53 8330 42682 29523462
Anaesthetic complication neurological 36.97 23.76 10 8373 315 29565829
Multiple organ dysfunction syndrome 36.88 23.76 65 8318 63051 29503093
Thyrotoxic crisis 35.99 23.76 10 8373 349 29565795
Respiratory failure 35.20 23.76 82 8301 97049 29469095
Acidosis 35.18 23.76 26 8357 9679 29556465
Hypotonic-hyporesponsive episode 34.22 23.76 6 8377 20 29566124
Tachypnoea 32.71 23.76 30 8353 15085 29551059
Propofol infusion syndrome 31.84 23.76 11 8372 796 29565348
Endotracheal intubation 30.57 23.76 15 8368 2654 29563490
Blood catecholamines increased 30.36 23.76 5 8378 10 29566134
Diarrhoea 30.19 23.76 30 8353 332668 29233476
Fall 29.54 23.76 7 8376 177171 29388973
Drug reaction with eosinophilia and systemic symptoms 29.51 23.76 38 8345 27954 29538190
Muscle rigidity 29.24 23.76 23 8360 9388 29556756
Arthralgia 28.92 23.76 3 8380 139614 29426530
Drug ineffective 28.00 23.76 187 8196 362983 29203161
Trigemino-cardiac reflex 27.54 23.76 7 8376 172 29565972
Dizziness 27.06 23.76 10 8373 189674 29376470
Product measured potency issue 26.79 23.76 6 8377 84 29566060
Therapeutic product effect decreased 26.49 23.76 37 8346 29414 29536730
Apnoea 25.91 23.76 18 8365 6084 29560060
Catecholamine crisis 25.58 23.76 5 8378 34 29566110
Anaphylactoid reaction 25.52 23.76 12 8371 1933 29564211
Therapeutic product effect prolonged 25.48 23.76 7 8376 234 29565910
Headache 25.11 23.76 9 8374 173998 29392146
Oromandibular dystonia 24.87 23.76 8 8375 464 29565680
Hyperkalaemia 24.63 23.76 54 8329 61338 29504806
Electrocardiogram ST segment depression 24.20 23.76 12 8371 2173 29563971

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 1830.91 22.35 681 16065 67983 64414003
Anaphylactic shock 1590.69 22.35 500 16246 29828 64452158
Neuromuscular block prolonged 675.62 22.35 129 16617 848 64481138
Hypotension 548.23 22.35 578 16168 380396 64101590
Cardiac arrest 532.65 22.35 386 16360 153678 64328308
Bronchospasm 510.10 22.35 197 16549 21485 64460501
Hyperthermia malignant 421.55 22.35 103 16643 2356 64479630
Delayed recovery from anaesthesia 308.25 22.35 73 16673 1455 64480531
Circulatory collapse 262.88 22.35 142 16604 33590 64448396
Tachycardia 253.83 22.35 249 16497 149330 64332656
Serotonin syndrome 253.31 22.35 146 16600 39136 64442850
Bradycardia 245.08 22.35 220 16526 117999 64363987
Recurrence of neuromuscular blockade 218.56 22.35 39 16707 165 64481821
Pulseless electrical activity 178.35 22.35 80 16666 12659 64469327
Stress cardiomyopathy 175.33 22.35 72 16674 9185 64472801
Neuromuscular blockade 154.54 22.35 34 16712 480 64481506
Blood pressure decreased 152.54 22.35 147 16599 86052 64395934
Hypoventilation 139.06 22.35 54 16692 5952 64476034
Airway peak pressure increased 133.63 22.35 28 16718 309 64481677
Fatigue 132.14 22.35 19 16727 748711 63733275
Ventricular tachycardia 132.03 22.35 92 16654 34173 64447813
Oxygen saturation decreased 125.93 22.35 147 16599 107029 64374957
Procedural hypotension 123.55 22.35 37 16709 1849 64480137
Drug interaction 122.86 22.35 282 16464 361801 64120185
Airway complication of anaesthesia 122.47 22.35 27 16719 385 64481601
Kounis syndrome 122.00 22.35 41 16705 2984 64479002
Haemodynamic instability 119.51 22.35 64 16682 14848 64467138
Anaesthetic complication 116.18 22.35 38 16708 2541 64479445
Electrocardiogram ST segment elevation 115.87 22.35 50 16696 7209 64474777
Ventricular fibrillation 110.94 22.35 72 16674 23788 64458198
Unwanted awareness during anaesthesia 109.09 22.35 23 16723 262 64481724
Negative pressure pulmonary oedema 102.46 22.35 21 16725 206 64481780
Urticaria 100.55 22.35 155 16591 147162 64334824
Therapeutic product effect prolonged 95.02 22.35 23 16723 504 64481482
Myoglobin urine present 92.44 22.35 23 16723 567 64481419
Hypoxia 88.98 22.35 112 16634 88037 64393949
Endotracheal intubation complication 88.02 22.35 23 16723 693 64481293
Diarrhoea 86.47 22.35 40 16706 722664 63759322
Arthralgia 83.25 22.35 9 16737 442251 64039735
Paralysis 82.49 22.35 46 16700 11549 64470437
Arteriospasm coronary 81.87 22.35 36 16710 5429 64476557
Anaphylactoid reaction 76.81 22.35 33 16713 4705 64477281
Respiratory depression 76.67 22.35 57 16689 23386 64458600
Headache 75.56 22.35 22 16724 529445 63952541
Apnoea 73.19 22.35 41 16705 10381 64471605
Respiratory acidosis 72.58 22.35 40 16706 9815 64472171
Fall 72.36 22.35 11 16735 416815 64065171
Respiratory arrest 71.23 22.35 78 16668 52907 64429079
Nausea 69.99 22.35 61 16685 785739 63696247
Pulmonary oedema 65.53 22.35 91 16655 78583 64403403
Wrist surgery 64.09 22.35 18 16728 715 64481271
Muscle rigidity 62.84 22.35 45 16701 17428 64464558
Diabetes insipidus 62.01 22.35 28 16718 4493 64477493
Dystonia 55.35 22.35 43 16703 18822 64463164
Type I hypersensitivity 55.01 22.35 24 16722 3550 64478436
Pain in extremity 54.91 22.35 7 16739 303078 64178908
Anticholinergic syndrome 54.78 22.35 22 16724 2647 64479339
Decreased appetite 54.76 22.35 5 16741 281284 64200702
Anaphylactoid shock 54.66 22.35 16 16730 738 64481248
Vomiting 53.72 22.35 39 16707 551078 63930908
Skin test positive 53.49 22.35 17 16729 1036 64480950
Death 52.71 22.35 30 16716 482675 63999311
Laryngospasm 52.59 22.35 23 16723 3422 64478564
Dizziness 52.58 22.35 23 16723 430140 64051846
Finger deformity 52.34 22.35 26 16720 5160 64476826
Trigemino-cardiac reflex 51.00 22.35 12 16734 232 64481754
Anaesthetic complication neurological 50.47 22.35 14 16732 531 64481455
Postoperative delirium 49.43 22.35 11 16735 164 64481822
Multiple organ dysfunction syndrome 47.07 22.35 90 16656 101323 64380663
Respiratory failure 46.35 22.35 118 16628 161065 64320921
Angioedema 46.31 22.35 68 16678 61753 64420233
Neutropenia 44.71 22.35 5 16741 239619 64242367
Hypoxic-ischaemic encephalopathy 44.49 22.35 26 16720 7126 64474860
Amylase increased 44.45 22.35 29 16717 9656 64472330
Pulmonary alveolar haemorrhage 44.30 22.35 29 16717 9709 64472277
Maternal exposure during delivery 43.69 22.35 14 16732 876 64481110
Carcinoid crisis 43.60 22.35 12 16734 442 64481544
Erythema 42.86 22.35 126 16620 186944 64295042
Subcutaneous emphysema 42.75 22.35 16 16730 1593 64480393
Laryngeal oedema 42.00 22.35 25 16721 7088 64474898
Procedural complication 41.51 22.35 25 16721 7240 64474746
Anaesthetic complication pulmonary 40.72 22.35 8 16738 62 64481924
Thyrotoxic crisis 40.58 22.35 14 16732 1102 64480884
Limb operation 40.42 22.35 18 16728 2796 64479190
Back pain 40.30 22.35 8 16738 250163 64231823
Clonus 40.26 22.35 23 16723 6044 64475942
Asthenia 39.48 22.35 32 16714 428012 64053974
Procedural haemorrhage 39.05 22.35 20 16726 4232 64477754
Weight decreased 38.66 22.35 13 16733 285726 64196260
Acidosis 38.51 22.35 34 16712 17761 64464225
Atrioventricular dissociation 37.84 22.35 10 16736 315 64481671
Pruritus 37.67 22.35 17 16729 312383 64169603
Shock 37.61 22.35 48 16698 38192 64443794
Malaise 37.32 22.35 29 16717 396218 64085768
Product measured potency issue 37.32 22.35 9 16737 194 64481792
Rhabdomyolysis 37.26 22.35 77 16669 91649 64390337
Atrioventricular block second degree 36.33 22.35 22 16724 6432 64475554
Propofol infusion syndrome 35.52 22.35 14 16732 1603 64480383
Upper airway obstruction 35.22 22.35 13 16733 1245 64480741
Tracheal injury 35.21 22.35 7 16739 58 64481928
Endotracheal intubation 34.85 22.35 18 16728 3877 64478109
Toxic encephalopathy 34.65 22.35 25 16721 9790 64472196
Intensive care unit acquired weakness 34.63 22.35 14 16732 1713 64480273
Anaemia 34.06 22.35 29 16717 378651 64103335
Exposure during pregnancy 33.68 22.35 67 16679 77608 64404378
Torsade de pointes 33.30 22.35 31 16715 17332 64464654
Hypercapnia 32.79 22.35 22 16724 7672 64474314
Dehydration 32.74 22.35 8 16738 216755 64265231
Tenosynovitis 32.62 22.35 26 16720 11807 64470179
Cardio-respiratory arrest 32.48 22.35 76 16670 98317 64383669
Troponin increased 32.48 22.35 29 16717 15370 64466616
Hypertensive crisis 31.99 22.35 31 16715 18217 64463769
Hyperreflexia 31.82 22.35 21 16725 7127 64474859
Hypotonia 31.69 22.35 25 16721 11187 64470799
Pain 31.51 22.35 60 16686 553451 63928535
Vasoplegia syndrome 31.31 22.35 15 16731 2752 64479234
Abdominal discomfort 31.15 22.35 5 16741 182317 64299669
Gait disturbance 31.09 22.35 4 16742 172151 64309835
Insomnia 30.47 22.35 7 16739 197829 64284157
Tachypnoea 30.40 22.35 36 16710 26535 64455451
Atrioventricular block complete 30.11 22.35 27 16719 14391 64467595
Premature delivery 29.66 22.35 30 16716 18559 64463427
Coronary artery embolism 29.24 22.35 8 16738 288 64481698
Completed suicide 28.99 22.35 11 16735 224403 64257583
Phaeochromocytoma crisis 28.95 22.35 8 16738 299 64481687
Pneumonia 28.20 22.35 65 16681 559511 63922475
Spinal cord infarction 28.06 22.35 9 16737 565 64481421
Blood catecholamines increased 26.42 22.35 5 16741 31 64481955
Catecholamine crisis 26.02 22.35 5 16741 34 64481952
COVID-19 treatment 25.98 22.35 8 16738 439 64481547
Post procedural stroke 25.95 22.35 6 16740 107 64481879
Resuscitation 25.92 22.35 12 16734 2039 64479947
Infection 25.72 22.35 8 16738 184872 64297114
Abdominal pain 25.62 22.35 26 16720 312349 64169637
Muscle twitching 25.57 22.35 28 16718 18970 64463016
Post procedural haemorrhage 25.41 22.35 23 16723 12408 64469578
Abdominal pain upper 25.39 22.35 7 16739 175023 64306963
Constipation 25.34 22.35 14 16732 229323 64252663
Sinusitis 24.93 22.35 4 16742 145924 64336062
Electrocardiogram ST segment depression 24.81 22.35 15 16731 4374 64477612
Renal injury 24.80 22.35 25 16721 15404 64466582
Paraplegia 24.49 22.35 15 16731 4475 64477511
Urinary tract infection 24.36 22.35 15 16731 231581 64250405
Fear 24.19 22.35 28 16718 20143 64461843
Ventricular arrhythmia 24.17 22.35 18 16728 7397 64474589
Spirometry abnormal 23.99 22.35 8 16738 568 64481418
Therapeutic product effect increased 23.94 22.35 10 16736 1330 64480656
Pulse absent 23.26 22.35 19 16727 8927 64473059
Myasthenic syndrome 23.10 22.35 8 16738 637 64481349
Febrile neutropenia 22.93 22.35 10 16736 187647 64294339
Hypothermia 22.88 22.35 27 16719 19829 64462157
Procedural vomiting 22.76 22.35 8 16738 666 64481320
Metabolic acidosis 22.53 22.35 54 16692 70904 64411082
Neuroleptic malignant syndrome 22.44 22.35 30 16716 24966 64457020

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AC09 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:51371 muscle relaxants
FDA EPC N0000175720 Nondepolarizing Neuromuscular Blocker
FDA PE N0000175732 Neuromuscular Nondepolarizing Blockade

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004
General anesthesia indication 50697003
Skeletal Muscle Relaxation for Endotracheal Intubation indication
Respiratory acidosis contraindication 12326000
Alkalosis contraindication 21420006
Acidosis contraindication 51387008
Eaton-Lambert syndrome contraindication 56989000 DOID:0050214
Pulmonary hypertension contraindication 70995007 DOID:6432
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Respiratory alkalosis contraindication 111378004
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Malignant hyperthermia contraindication 405501007




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor Ion channel ANTAGONIST IC50 7.77 WOMBAT-PK CHEMBL
Acetylcholine receptor; alpha1/beta1/delta/gamma Ion channel IC50 7.09 CHEMBL

External reference:

IDSource
D00765 KEGG_DRUG
4020866 VANDF
C0209337 UMLSCUI
CHEBI:8885 CHEBI
CHEMBL1201244 ChEMBL_ID
CHEMBL1200648 ChEMBL_ID
D000077123 MESH_DESCRIPTOR_UI
DB00728 DRUGBANK_ID
4003 IUPHAR_LIGAND_ID
WRE554RFEZ UNII
441290 PUBCHEM_CID
151718 RXNORM
1460 MMSL
159147 MMSL
5433 MMSL
d03766 MMSL
004442 NDDF
013418 NDDF
108449002 SNOMEDCT_US
108450002 SNOMEDCT_US
372494005 SNOMEDCT_US
6864 INN_ID
143558-00-3 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9250 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9250 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9251 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9251 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9558 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9558 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3220 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 25021-662 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 27 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 39822-4200 SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-007 INJECTION 50 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-013 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43547-530 INJECTION 50 mg INTRAVENOUS ANDA 25 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43547-531 INJECTION 100 mg INTRAVENOUS ANDA 25 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1354 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1355 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1545 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1546 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-225 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-226 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 25 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 63323-426 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 65219-065 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 66794-228 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 17 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 66794-229 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 67457-228 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide Human Prescription Drug Label 1 68083-364 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide Human Prescription Drug Label 1 68083-365 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 70860-651 SOLUTION 10 mg INTRAVENOUS ANDA 27 sections
Rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 71479-004 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 29 sections
Rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 71479-005 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 29 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 71872-7036 SOLUTION 10 mg INTRAVENOUS ANDA 26 sections