rocuronium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 2396 119302-91-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ORG-9426
  • ORG 9426
  • rocuronium
  • rocuronium bromide
  • zemuron
  • esmeron
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
  • Molecular weight: 529.79
  • Formula: C32H53N2O4
  • CLOGP: 2.23
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 1
  • TPSA: 59
  • ALOGS: -7.30
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 17 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.54 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 122 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,NTRK2,PDK1,PDK2,PDK4,PRKDC 14
kinase-selectivity-class MAP2K6 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
March 17, 1994 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 2268.55 30.56 591 13226 31026 90583604
Anaphylactic reaction 1943.52 30.56 660 13157 86864 90527766
Hypotension 785.91 30.56 531 13286 324866 90289764
Bronchospasm 638.46 30.56 201 13616 20508 90594122
Cardiac arrest 598.33 30.56 300 13517 104635 90509995
Neuromuscular block prolonged 442.21 30.56 78 13739 574 90614056
Circulatory collapse 333.71 30.56 130 13687 24774 90589856
Serotonin syndrome 315.94 30.56 141 13676 37746 90576884
Tachycardia 285.85 30.56 217 13600 157456 90457174
Stress cardiomyopathy 280.14 30.56 97 13720 13258 90601372
Myoglobin urine present 265.62 30.56 52 13765 710 90613920
Recurrence of neuromuscular blockade 254.45 30.56 41 13776 159 90614471
Delayed recovery from anaesthesia 249.99 30.56 52 13765 978 90613652
Drug interaction 238.80 30.56 250 13567 276203 90338427
Bradycardia 225.46 30.56 147 13670 83700 90530930
Toxic encephalopathy 174.00 30.56 61 13756 8638 90605992
Amylase increased 162.45 30.56 55 13762 7017 90607613
Therapeutic product effect prolonged 161.20 30.56 31 13786 383 90614247
Kounis syndrome 155.07 30.56 42 13775 2511 90612119
Maternal exposure during delivery 150.98 30.56 45 13772 3801 90610829
Procedural hypotension 144.09 30.56 36 13781 1564 90613066
Oxygen saturation decreased 137.70 30.56 121 13696 107362 90507268
Premature delivery 137.16 30.56 81 13736 38681 90575949
Hypoventilation 136.80 30.56 45 13772 5251 90609379
Airway peak pressure increased 136.41 30.56 27 13790 391 90614239
Troponin increased 125.43 30.56 54 13763 13227 90601403
Unwanted awareness during anaesthesia 124.87 30.56 25 13792 385 90614245
Ventricular tachycardia 124.03 30.56 65 13752 24643 90589987
Pulseless electrical activity 117.35 30.56 46 13771 8886 90605744
Hypoxia 116.49 30.56 93 13724 72306 90542324
Haemodynamic instability 115.05 30.56 49 13768 11690 90602940
Blood pressure decreased 113.72 30.56 93 13724 74802 90539828
Fatigue 111.18 30.56 21 13796 1154002 89460628
Skin test positive 110.51 30.56 26 13791 874 90613756
Hyperthermia malignant 105.95 30.56 27 13790 1271 90613359
Blood lactate dehydrogenase increased 104.54 30.56 59 13758 25873 90588757
Wrist surgery 104.07 30.56 25 13792 920 90613710
Paralysis 102.94 30.56 45 13772 11433 90603197
Blood potassium increased 99.64 30.56 53 13764 20696 90593934
Arthralgia 95.25 30.56 6 13811 778516 89836114
Blood creatine phosphokinase increased 92.19 30.56 60 13757 33963 90580667
Neuromuscular blockade 91.85 30.56 19 13798 347 90614283
Angioedema 91.07 30.56 77 13740 64799 90549831
Airway complication of anaesthesia 88.53 30.56 19 13798 417 90614213
Ventricular fibrillation 88.20 30.56 43 13774 14001 90600629
Apnoea 87.98 30.56 38 13779 9376 90605254
Type I hypersensitivity 78.75 30.56 28 13789 4127 90610503
Diarrhoea 78.65 30.56 23 13794 939167 89675463
Headache 78.20 30.56 18 13799 862728 89751902
Breast cancer recurrent 74.61 30.56 29 13788 5474 90609156
Postoperative delirium 70.77 30.56 14 13803 202 90614428
Anaphylactoid reaction 69.40 30.56 26 13791 4442 90610188
Tenosynovitis 69.35 30.56 37 13780 14530 90600100
Dystonia 67.06 30.56 38 13779 16781 90597849
Nausea 66.57 30.56 44 13773 1110272 89504358
Anaphylactoid shock 66.29 30.56 15 13802 423 90614207
Limb operation 65.45 30.56 25 13792 4502 90610128
Anaesthetic complication 63.88 30.56 21 13796 2444 90612186
Anticholinergic syndrome 61.68 30.56 21 13796 2722 90611908
Endotracheal intubation complication 60.50 30.56 14 13803 437 90614193
Vocal cord dysfunction 60.04 30.56 16 13801 898 90613732
Laryngeal oedema 58.54 30.56 26 13791 6855 90607775
Exposure during pregnancy 56.36 30.56 117 13700 238293 90376337
Abdominal discomfort 54.55 30.56 5 13812 477323 90137307
Urticaria 54.51 30.56 136 13681 312598 90302032
Respiratory acidosis 54.42 30.56 26 13791 8093 90606537
Maternal exposure during pregnancy 51.03 30.56 145 13672 359918 90254712
Pain 50.17 30.56 47 13770 996294 89618336
Fall 50.16 30.56 7 13810 481803 90132827
Vasoplegia syndrome 49.70 30.56 18 13799 2796 90611834
Anaesthetic complication neurological 48.81 30.56 13 13804 728 90613902
Allergy test positive 48.79 30.56 13 13804 729 90613901
Alanine aminotransferase increased 48.60 30.56 74 13743 118264 90496366
Respiratory failure 48.56 30.56 74 13743 118344 90496286
Muscle rigidity 48.24 30.56 29 13788 14280 90600350
Altered state of consciousness 47.49 30.56 39 13778 31493 90583137
Hyperreflexia 46.71 30.56 22 13795 6635 90607995
Myasthenic syndrome 46.43 30.56 11 13806 381 90614249
Weight decreased 46.15 30.56 3 13814 379907 90234723
Pulmonary oedema 46.12 30.56 52 13765 62028 90552602
Pruritus 45.70 30.56 13 13804 541512 90073118
Respiratory arrest 45.62 30.56 39 13778 33272 90581358
Finger deformity 44.01 30.56 38 13779 32859 90581771
Carcinoid crisis 43.99 30.56 10 13807 288 90614342
Diabetes insipidus 43.80 30.56 17 13800 3195 90611435
Hypercapnia 43.59 30.56 21 13796 6656 90607974
Subcutaneous emphysema 43.59 30.56 13 13804 1099 90613531
Erythema 43.44 30.56 103 13714 229143 90385487
Laryngospasm 43.19 30.56 17 13800 3316 90611314
Dizziness 43.09 30.56 18 13799 589266 90025364
Decreased appetite 42.85 30.56 4 13813 376536 90238094
Arteriospasm coronary 42.69 30.56 19 13798 5031 90609599
Tryptase increased 42.40 30.56 11 13806 556 90614074
Pain in extremity 41.53 30.56 9 13808 450520 90164110
Cardiac output decreased 40.31 30.56 12 13805 1008 90613622
Neuromuscular blocking therapy 40.14 30.56 6 13811 12 90614618
Shock 40.04 30.56 34 13783 28744 90585886
Mydriasis 39.49 30.56 26 13791 14986 90599644
Circumoral oedema 38.44 30.56 9 13808 296 90614334
Infection 38.29 30.56 5 13812 362089 90252541
Vomiting 37.53 30.56 39 13778 788254 89826376
Therapeutic product effect increased 37.45 30.56 12 13805 1287 90613343
Torsade de pointes 36.82 30.56 25 13792 15157 90599473
Insomnia 36.75 30.56 4 13813 333470 90281160
Multiple organ dysfunction syndrome 35.80 30.56 48 13769 68288 90546342
Unresponsive to stimuli 35.50 30.56 36 13781 38085 90576545
Atrioventricular dissociation 35.31 30.56 8 13809 227 90614403
Increased bronchial secretion 35.16 30.56 13 13804 2140 90612490
Neurodevelopmental disorder 34.72 30.56 8 13809 245 90614385
Pulmonary hypertensive crisis 34.44 30.56 9 13808 468 90614162
Isoimmune haemolytic disease 34.39 30.56 6 13811 41 90614589
Clonus 34.29 30.56 17 13800 5733 90608897
Acute generalised exanthematous pustulosis 34.28 30.56 23 13794 13680 90600950
Brachial plexopathy 34.26 30.56 8 13809 260 90614370
Malaise 33.95 30.56 24 13793 585962 90028668
Post procedural complication 33.92 30.56 26 13791 19016 90595614
Respiratory depression 33.91 30.56 24 13793 15551 90599079
Hepatic enzyme increased 33.65 30.56 7 13810 360729 90253901
Hyperdynamic left ventricle 33.52 30.56 8 13809 286 90614344
Oesophageal intramural haematoma 33.09 30.56 7 13810 143 90614487
Hypotonia 33.04 30.56 21 13796 11405 90603225
Post procedural stroke 32.63 30.56 6 13811 57 90614573
Tracheal injury 32.10 30.56 7 13810 166 90614464
Abdominal pain upper 31.98 30.56 6 13811 332668 90281962
Death 31.69 30.56 15 13802 456536 90158094
Hypothermia 31.62 30.56 23 13794 15552 90599078
Hypertensive crisis 31.06 30.56 24 13793 17760 90596870
Irregular breathing 30.90 30.56 8 13809 401 90614229
Coronary artery embolism 30.88 30.56 7 13810 199 90614431

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 1607.22 24.31 492 12439 23025 42585379
Anaphylactic reaction 1170.07 24.31 451 12480 42292 42566112
Hyperthermia malignant 557.76 24.31 135 12796 2523 42605881
Hypotension 421.30 24.31 450 12481 257181 42351223
Neuromuscular block prolonged 350.77 24.31 71 12860 548 42607856
Bronchospasm 347.74 24.31 135 12796 12750 42595654
Cardiac arrest 335.75 24.31 272 12659 109048 42499356
Recurrence of neuromuscular blockade 327.69 24.31 59 12872 219 42608185
Bradycardia 203.43 24.31 184 12747 85300 42523104
Delayed recovery from anaesthesia 192.94 24.31 49 12882 1120 42607284
Negative pressure pulmonary oedema 185.07 24.31 42 12889 583 42607821
Tachycardia 150.84 24.31 169 12762 100918 42507486
Airway peak pressure increased 123.22 24.31 24 12907 148 42608256
Kounis syndrome 122.65 24.31 44 12887 3324 42605080
Hypoxia 120.33 24.31 126 12805 69660 42538744
Pulseless electrical activity 119.46 24.31 56 12875 8381 42600023
Circulatory collapse 113.14 24.31 77 12854 23559 42584845
Urticaria 110.71 24.31 124 12807 73912 42534492
Respiratory depression 108.65 24.31 69 12862 18799 42589605
Haemodynamic instability 106.59 24.31 59 12872 12498 42595906
Neuromuscular blockade 106.16 24.31 24 12907 327 42608077
Mechanical ventilation complication 103.91 24.31 27 12904 677 42607727
Procedural hypotension 103.49 24.31 29 12902 974 42607430
Diabetes insipidus 100.42 24.31 39 12892 3674 42604730
Oxygen saturation decreased 99.54 24.31 110 12821 64577 42543827
Fatigue 96.94 24.31 10 12921 435631 42172773
Blood pressure decreased 96.39 24.31 103 12828 58229 42550175
Anaesthetic complication 92.80 24.31 29 12902 1428 42606976
Endotracheal intubation complication 86.70 24.31 21 12910 392 42608012
Hypoventilation 78.87 24.31 33 12898 3769 42604635
Laryngospasm 76.27 24.31 27 12904 1961 42606443
Respiratory arrest 75.04 24.31 65 12866 28359 42580045
Respiratory failure 74.82 24.31 137 12794 127995 42480409
Electrocardiogram ST segment elevation 73.66 24.31 36 12895 5903 42602501
Airway complication of anaesthesia 73.51 24.31 16 12915 181 42608223
Trigemino-cardiac reflex 73.47 24.31 18 12913 353 42608051
Arteriospasm coronary 65.68 24.31 31 12900 4707 42603697
Diarrhoea 64.11 24.31 30 12901 460819 42147585
Shock 61.96 24.31 59 12872 29062 42579342
Death 60.59 24.31 34 12897 471151 42137253
Serotonin syndrome 60.06 24.31 55 12876 25790 42582614
Respiratory acidosis 59.97 24.31 32 12899 6299 42602105
Ventricular fibrillation 58.41 24.31 58 12873 30065 42578339
Cardio-respiratory arrest 58.21 24.31 80 12851 58556 42549848
Ventricular tachycardia 56.51 24.31 57 12874 30103 42578301
Inspiratory capacity decreased 55.72 24.31 24 12907 2943 42605461
Drug ineffective 53.81 24.31 350 12581 629847 41978557
Hypercapnia 53.34 24.31 28 12903 5333 42603071
Therapeutic product effect prolonged 50.85 24.31 13 12918 305 42608099
Hyperkalaemia 48.13 24.31 87 12844 80371 42528033
Adverse reaction 45.93 24.31 23 12908 3970 42604434
Acidosis 44.94 24.31 34 12897 12245 42596159
Angiopathy 44.89 24.31 25 12906 5352 42603052
Arthralgia 44.79 24.31 5 12926 205233 42403171
Pulmonary oedema 44.54 24.31 67 12864 53205 42555199
Decreased appetite 43.97 24.31 4 12927 193133 42415271
Multiple organ dysfunction syndrome 43.57 24.31 93 12838 96942 42511462
Hypoxic-ischaemic encephalopathy 42.92 24.31 24 12907 5178 42603226
Haemothorax 42.77 24.31 24 12907 5212 42603192
Rhabdomyolysis 42.45 24.31 81 12850 77938 42530466
Brain oedema 42.39 24.31 37 12894 16290 42592114
Unwanted awareness during anaesthesia 42.00 24.31 8 12923 43 42608361
Intensive care unit acquired weakness 40.23 24.31 15 12916 1263 42607141
Dizziness 39.88 24.31 13 12918 249241 42359163
Erythema 39.65 24.31 96 12835 108697 42499707
Burkholderia test positive 39.29 24.31 14 12917 1036 42607368
Headache 39.16 24.31 12 12919 239357 42369047
Nausea 38.83 24.31 38 12893 396761 42211643
Thyrotoxic crisis 38.47 24.31 13 12918 821 42607583
Hypocapnia 38.20 24.31 11 12920 408 42607996
Hypovolaemia 38.10 24.31 30 12901 11455 42596949
Fall 37.93 24.31 12 12919 234508 42373896
Pneumothorax 37.83 24.31 41 12890 23502 42584902
Anaesthetic complication pulmonary 37.74 24.31 8 12923 79 42608325
Allergy test negative 37.67 24.31 9 12922 158 42608246
Propofol infusion syndrome 37.36 24.31 14 12917 1195 42607209
Hypersensitivity 36.76 24.31 73 12858 72297 42536107
Paralysis 36.28 24.31 24 12907 6996 42601408
Anaemia 36.25 24.31 20 12911 280258 42328146
Prinzmetal angina 35.79 24.31 14 12917 1343 42607061
Febrile neutropenia 34.84 24.31 7 12924 185696 42422708
Malaise 34.04 24.31 11 12920 212145 42396259
Therapeutic product effect decreased 33.80 24.31 50 12881 39100 42569304
Procedural complication 33.55 24.31 19 12912 4200 42604204
Hypotonic-hyporesponsive episode 33.16 24.31 6 12925 23 42608381
Shock haemorrhagic 32.82 24.31 32 12899 16210 42592194
Endotracheal intubation 32.70 24.31 18 12913 3767 42604637
Sinus arrest 32.65 24.31 15 12916 2141 42606263
Ventricular asystole 32.44 24.31 9 12922 291 42608113
Weight decreased 31.28 24.31 12 12919 207936 42400468
Acute respiratory distress syndrome 31.25 24.31 42 12889 30066 42578338
Face oedema 29.65 24.31 28 12903 13638 42594766
Pulmonary alveolar haemorrhage 29.58 24.31 29 12902 14787 42593617
Dehydration 29.57 24.31 4 12927 141763 42466641
Apnoea 29.43 24.31 22 12909 7781 42600623
Neutropenia 29.18 24.31 12 12919 199419 42408985
Vomiting 29.17 24.31 27 12904 289696 42318708
Stress cardiomyopathy 29.00 24.31 15 12916 2770 42605634
Muscle rigidity 28.66 24.31 26 12905 12033 42596371
Pneumonia 28.53 24.31 53 12878 422096 42186308
Asthenia 28.47 24.31 26 12905 280767 42327637
Drug reaction with eosinophilia and systemic symptoms 28.39 24.31 48 12883 42027 42566377
Anaesthetic complication neurological 28.25 24.31 10 12921 726 42607678
Confusional state 28.12 24.31 8 12923 167589 42440815
Upper airway obstruction 27.50 24.31 10 12921 784 42607620
Wrong product administered 26.76 24.31 19 12912 6207 42602197
Pseudocholinesterase deficiency 26.59 24.31 6 12925 81 42608323
Electrocardiogram ST segment depression 26.39 24.31 14 12917 2723 42605681
Oromandibular dystonia 26.06 24.31 9 12922 607 42607797
Atrioventricular block complete 26.03 24.31 24 12907 11340 42597064
Blood catecholamines increased 25.93 24.31 5 12926 29 42608375
Procedural haemorrhage 25.90 24.31 14 12917 2827 42605577
Sinus bradycardia 25.87 24.31 27 12904 14826 42593578
Local anaesthetic systemic toxicity 25.73 24.31 13 12918 2287 42606117
Product measured potency issue 25.64 24.31 6 12925 96 42608308
Electrocardiogram QRS complex prolonged 25.56 24.31 18 12913 5805 42602599
Thrombocytopenia 25.43 24.31 13 12918 190266 42418138
Atrioventricular block 25.38 24.31 22 12909 9593 42598811
Tachypnoea 25.25 24.31 32 12899 21630 42586774
Electroencephalogram abnormal 25.22 24.31 14 12917 2978 42605426
Emphysema 25.20 24.31 24 12907 11811 42596593
Drug interaction 24.87 24.31 152 12779 266847 42341557
Metabolic acidosis 24.76 24.31 51 12880 51807 42556597
Neuromuscular blocking therapy 24.74 24.31 4 12927 6 42608398
Neonatal respiratory depression 24.43 24.31 8 12923 458 42607946

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 3727.16 24.45 1059 24493 50487 110513260
Anaphylactic reaction 2834.42 24.45 1042 24510 113258 110450489
Hypotension 1075.62 24.45 918 24634 522931 110040816
Bronchospasm 889.73 24.45 314 25238 29925 110533822
Cardiac arrest 866.65 24.45 548 25004 196205 110367542
Neuromuscular block prolonged 751.54 24.45 144 25408 1103 110562644
Hyperthermia malignant 654.56 24.45 157 25395 3743 110560004
Recurrence of neuromuscular blockade 462.03 24.45 81 25471 350 110563397
Tachycardia 419.64 24.45 376 25176 226269 110337478
Delayed recovery from anaesthesia 412.42 24.45 97 25455 2118 110561629
Circulatory collapse 408.11 24.45 199 25353 42794 110520953
Bradycardia 388.95 24.45 307 25245 155210 110408537
Serotonin syndrome 327 24.45 191 25361 58962 110504785
Stress cardiomyopathy 271.86 24.45 111 25441 15695 110548052
Kounis syndrome 271.57 24.45 86 25466 5839 110557908
Airway peak pressure increased 252.65 24.45 52 25500 593 110563154
Procedural hypotension 252.02 24.45 67 25485 2438 110561309
Myoglobin urine present 223.29 24.45 50 25502 870 110562877
Pulseless electrical activity 222.71 24.45 98 25454 16659 110547088
Oxygen saturation decreased 220.78 24.45 224 25328 156758 110406989
Haemodynamic instability 214.27 24.45 105 25447 22783 110540964
Blood pressure decreased 208.76 24.45 189 25363 114902 110448845
Drug interaction 207.57 24.45 395 25157 499788 110063959
Negative pressure pulmonary oedema 202.93 24.45 44 25508 655 110563092
Hypoxia 202.83 24.45 196 25356 129319 110434428
Neuromuscular blockade 189.14 24.45 42 25510 702 110563045
Fatigue 182.85 24.45 31 25521 1215927 109347820
Hypoventilation 178.42 24.45 68 25484 8013 110555734
Airway complication of anaesthesia 176.02 24.45 39 25513 645 110563102
Ventricular tachycardia 167.96 24.45 118 25434 49891 110513856
Therapeutic product effect prolonged 157.87 24.45 36 25516 682 110563065
Diabetes insipidus 147.62 24.45 56 25496 6514 110557233
Anaesthetic complication 139.39 24.45 46 25506 3560 110560187
Arthralgia 138.95 24.45 11 25541 779621 109784126
Ventricular fibrillation 137.60 24.45 97 25455 41216 110522531
Diarrhoea 134.50 24.45 48 25504 1139457 109424290
Maternal exposure during delivery 131.90 24.45 44 25508 3521 110560226
Unwanted awareness during anaesthesia 131.47 24.45 28 25524 381 110563366
Endotracheal intubation complication 125.80 24.45 31 25521 828 110562919
Respiratory failure 125.66 24.45 198 25354 215134 110348613
Mechanical ventilation complication 123.99 24.45 30 25522 741 110563006
Skin test positive 123.46 24.45 34 25518 1415 110562332
Paralysis 120.92 24.45 63 25489 15537 110548210
Laryngospasm 120.29 24.45 44 25508 4624 110559123
Urticaria 118.85 24.45 241 25311 318616 110245131
Headache 116.98 24.45 30 25522 882347 109681400
Respiratory acidosis 113.40 24.45 58 25494 13768 110549979
Respiratory depression 113.26 24.45 78 25474 31923 110531824
Amylase increased 112.89 24.45 56 25496 12463 110551284
Respiratory arrest 112.08 24.45 99 25453 58200 110505547
Toxic encephalopathy 110.98 24.45 59 25493 15155 110548592
Electrocardiogram ST segment elevation 110.28 24.45 50 25502 9110 110554637
Arteriospasm coronary 107.43 24.45 49 25503 9051 110554696
Hypercapnia 103.84 24.45 51 25501 11108 110552639
Nausea 103.29 24.45 81 25471 1235609 109328138
Shock 101.02 24.45 90 25462 53498 110510249
Trigemino-cardiac reflex 100.25 24.45 23 25529 448 110563299
Angioedema 97.49 24.45 117 25435 98383 110465364
Apnoea 94.18 24.45 51 25501 13588 110550159
Pulmonary oedema 90.63 24.45 114 25438 100545 110463202
Type I hypersensitivity 90.17 24.45 39 25513 6354 110557393
Premature delivery 88.51 24.45 66 25486 30566 110533181
Weight increased 83.71 24.45 3 25549 419641 110144106
Dizziness 82.90 24.45 29 25523 698164 109865583
Anaesthetic complication neurological 82.32 24.45 23 25529 1010 110562737
Decreased appetite 81.19 24.45 8 25544 475838 110087909
Pain in extremity 81.03 24.45 9 25543 487109 110076638
Fall 80.88 24.45 20 25532 603462 109960285
Anaphylactoid reaction 78.20 24.45 36 25516 6790 110556957
Drug intolerance 77.46 24.45 4 25548 406508 110157239
Muscle rigidity 74.44 24.45 54 25498 23977 110539770
Multiple organ dysfunction syndrome 74.31 24.45 129 25423 151581 110412166
Anticholinergic syndrome 73.38 24.45 30 25522 4250 110559497
Dystonia 73.21 24.45 55 25497 25750 110537997
Infusion related reaction 71.84 24.45 4 25548 381158 110182589
Drug ineffective 70.98 24.45 595 24957 1519945 109043802
Erythema 70.59 24.45 186 25366 291261 110272486
Troponin increased 70.47 24.45 57 25495 29709 110534038
Malaise 69.89 24.45 34 25518 671785 109891962
Anaphylactoid shock 69.73 24.45 20 25532 966 110562781
Pain 69.58 24.45 71 25481 954884 109608863
Cardio-respiratory arrest 69.56 24.45 108 25444 115728 110448019
Vomiting 69.48 24.45 65 25487 910610 109653137
Pruritus 69.27 24.45 24 25528 581536 109982211
Abdominal discomfort 68.83 24.45 6 25546 393852 110169895
Postoperative delirium 66.69 24.45 19 25533 896 110562851
Vocal cord dysfunction 65.98 24.45 19 25533 931 110562816
Inspiratory capacity decreased 65.16 24.45 24 25528 2571 110561176
Weight decreased 63.69 24.45 15 25537 468042 110095705
Laryngeal oedema 63.09 24.45 35 25517 9772 110553975
Wrist surgery 62.89 24.45 18 25534 863 110562884
Neutropenia 62.08 24.45 7 25545 374613 110189134
Anaesthetic complication pulmonary 61.87 24.45 13 25539 165 110563582
Neuromuscular blocking therapy 61.50 24.45 10 25542 24 110563723
Blood potassium increased 60.99 24.45 55 25497 33194 110530553
Pneumothorax 60.11 24.45 56 25496 35229 110528518
Death 59.25 24.45 45 25507 698824 109864923
Hypoxic-ischaemic encephalopathy 58.09 24.45 32 25520 8815 110554932
Procedural complication 56.84 24.45 31 25521 8374 110555373
Carcinoid crisis 56.56 24.45 15 25537 540 110563207
Blood lactate dehydrogenase increased 56.35 24.45 60 25492 44274 110519473
Asthenia 56.34 24.45 46 25506 688953 109874794
Shock haemorrhagic 55.84 24.45 48 25504 27199 110536548
Blood creatine phosphokinase increased 53.78 24.45 75 25477 73002 110490745
Sinusitis 53.27 24.45 4 25548 296684 110267063
Pulmonary alveolar haemorrhage 52.88 24.45 41 25511 20109 110543638
Abdominal pain upper 52.03 24.45 9 25543 349102 110214645
Acidosis 50.92 24.45 42 25510 22489 110541258
Rhabdomyolysis 50.82 24.45 96 25456 120305 110443442
Sinus arrest 50.57 24.45 23 25529 4219 110559528
Infection 50.47 24.45 11 25541 362189 110201558
Insomnia 50.15 24.45 11 25541 360579 110203168
Allergy test positive 49.02 24.45 15 25537 908 110562839
Torsade de pointes 48.74 24.45 41 25511 22559 110541188
Hypertensive crisis 48.05 24.45 42 25510 24330 110539417
Stomatitis 47.52 24.45 4 25548 270238 110293509
Subcutaneous emphysema 47.35 24.45 19 25533 2565 110561182
Gait disturbance 46.58 24.45 5 25547 278203 110285544
Upper airway obstruction 46.48 24.45 17 25535 1785 110561962
Hypotonia 45.64 24.45 34 25518 15711 110548036
Endotracheal intubation 45.29 24.45 24 25528 6120 110557627
Abdominal pain 44.77 24.45 32 25520 512957 110050790
Lower respiratory tract infection 44.44 24.45 3 25549 243103 110320644
Thyrotoxic crisis 44.43 24.45 17 25535 2023 110561724
Pyrexia 44.32 24.45 88 25464 898177 109665570
Anaemia 44.11 24.45 37 25515 547049 110016698
Propofol infusion syndrome 43.88 24.45 18 25534 2571 110561176
Procedural haemorrhage 42.29 24.45 22 25530 5405 110558342
Haemothorax 42.26 24.45 24 25528 7007 110556740
Vasoplegia syndrome 42.24 24.45 22 25530 5417 110558330
Drug reaction with eosinophilia and systemic symptoms 41.74 24.45 71 25481 82024 110481723
Hypocapnia 40.66 24.45 13 25539 909 110562838
Myasthenic syndrome 40.35 24.45 14 25538 1262 110562485
Face oedema 40.26 24.45 44 25508 33425 110530322
Angiopathy 39.96 24.45 25 25527 8705 110555042
Dehydration 39.94 24.45 8 25544 279503 110284244
Hypothermia 39.60 24.45 39 25513 26263 110537484
Paraplegia 39.54 24.45 22 25530 6178 110557569
Atrioventricular block second degree 38.89 24.45 24 25528 8157 110555590
Resuscitation 38.46 24.45 17 25535 2916 110560831
Atrioventricular block complete 38.37 24.45 34 25518 20048 110543699
Dyskinesia 38.15 24.45 53 25499 51393 110512354
Swelling 37.63 24.45 17 25535 351024 110212723
Product measured potency issue 37.60 24.45 9 25543 212 110563535
Clonus 37.50 24.45 24 25528 8692 110555055
Hyperdynamic left ventricle 37.40 24.45 11 25541 581 110563166
Cardiac output decreased 37.17 24.45 15 25537 2054 110561693
Atrioventricular dissociation 37.08 24.45 10 25542 384 110563363
Pseudocholinesterase deficiency 36.90 24.45 9 25543 230 110563517
Product administered to patient of inappropriate age 36.75 24.45 23 25529 8013 110555734
Local anaesthetic systemic toxicity 36.27 24.45 20 25532 5517 110558230
Limb operation 36.27 24.45 18 25534 4006 110559741
Therapeutic product effect increased 36.23 24.45 14 25538 1711 110562036
Hypovolaemia 36.15 24.45 34 25518 21640 110542107
Acute respiratory distress syndrome 35.32 24.45 52 25500 53146 110510601
Intensive care unit acquired weakness 35.27 24.45 15 25537 2344 110561403
Hyperkalaemia 35.23 24.45 89 25463 135707 110428040
Post procedural haemorrhage 35.23 24.45 29 25523 15483 110548264
Accelerated idioventricular rhythm 35.11 24.45 9 25543 283 110563464
Gastrointestinal disorder 34.41 24.45 7 25545 241945 110321802
Musculoskeletal stiffness 34.23 24.45 11 25541 279811 110283936
Sinus bradycardia 34.15 24.45 38 25514 29445 110534302
Dyspnoea 34.14 24.45 136 25416 1106736 109457011
Pulse absent 34.12 24.45 25 25527 11267 110552480
General physical health deterioration 33.97 24.45 29 25523 425266 110138481
Capnogram abnormal 33.93 24.45 5 25547 4 110563743
Electrocardiogram ST segment depression 33.79 24.45 19 25533 5442 110558305
Hyperreflexia 33.27 24.45 23 25529 9462 110554285
Metabolic acidosis 33.11 24.45 72 25480 99672 110464075
Atrioventricular block 33.10 24.45 29 25523 16848 110546899
Depression 33.03 24.45 16 25536 317319 110246428
Pneumonia 32.90 24.45 99 25453 876615 109687132
Exposure during pregnancy 32.79 24.45 99 25453 167325 110396422
Confusional state 32.75 24.45 36 25516 468644 110095103
Supraventricular tachycardia 32.72 24.45 34 25518 24388 110539359
Prinzmetal angina 32.52 24.45 14 25538 2255 110561492
Wrong product administered 32.52 24.45 24 25528 10936 110552811
Cardiogenic shock 32.38 24.45 52 25500 57286 110506461
Tryptase increased 32.36 24.45 11 25541 932 110562815
Allergy test negative 32.08 24.45 9 25543 401 110563346
Post procedural complication 31.98 24.45 35 25517 26623 110537124
Memory impairment 31.81 24.45 4 25548 196940 110366807
Ventricular asystole 31.68 24.45 9 25543 420 110563327
Urinary tract infection 31.67 24.45 18 25534 326264 110237483
Electroencephalogram abnormal 31.63 24.45 19 25533 6154 110557593
Circumoral oedema 31.53 24.45 9 25543 427 110563320
Neuroleptic malignant syndrome 31.31 24.45 39 25513 34020 110529727
Osteoarthritis 31.30 24.45 3 25549 182620 110381127
End-tidal CO2 increased 31.07 24.45 6 25546 48 110563699
Inappropriate schedule of product administration 30.88 24.45 5 25547 203632 110360115
Chest pain 30.87 24.45 25 25527 376350 110187397
Altered state of consciousness 30.83 24.45 51 25501 57575 110506172
Gastrooesophageal reflux disease 30.73 24.45 3 25549 179973 110383774
Oedema peripheral 30.68 24.45 19 25533 328641 110235106
Brachial plexopathy 29.90 24.45 8 25544 298 110563449
Hepatic enzyme increased 29.33 24.45 19 25533 320873 110242874
Discomfort 28.94 24.45 7 25545 214700 110349047
Coronary artery embolism 28.84 24.45 8 25544 342 110563405
Generalised tonic-clonic seizure 28.73 24.45 48 25504 54632 110509115
Oesophageal intramural haematoma 28.30 24.45 7 25545 190 110563557
Dyspepsia 28.27 24.45 5 25547 190960 110372787
Mydriasis 28.18 24.45 30 25522 22127 110541620
Tenosynovitis 28.03 24.45 26 25526 16257 110547490
Trismus 27.97 24.45 18 25534 6578 110557169
Injection site pain 27.82 24.45 4 25548 177918 110385829
Blister 27.70 24.45 9 25543 227367 110336380
Brain oedema 27.62 24.45 35 25517 31063 110532684
Muscle spasms 27.49 24.45 15 25537 278142 110285605
Emphysema 27.36 24.45 28 25524 19728 110544019
Febrile neutropenia 27.30 24.45 20 25532 316747 110247000
Malignant neoplasm progression 27.12 24.45 4 25548 174563 110389184
Tracheal injury 27.01 24.45 7 25545 230 110563517
Tachypnoea 26.87 24.45 39 25513 39356 110524391
Electrocardiogram QRS complex prolonged 26.80 24.45 23 25529 12998 110550749
Electrocardiogram QT prolonged 26.80 24.45 70 25482 108890 110454857
Constipation 26.66 24.45 26 25526 357760 110205987
Tongue oedema 26.59 24.45 19 25533 8237 110555510
Post procedural stroke 26.55 24.45 6 25546 109 110563638
Disease progression 25.86 24.45 12 25540 244022 110319725
Vasodilatation 25.85 24.45 14 25538 3730 110560017
Phaeochromocytoma crisis 25.80 24.45 8 25544 506 110563241
Eyelid oedema 25.56 24.45 24 25528 15238 110548509
Oculogyric crisis 25.54 24.45 14 25538 3818 110559929
Muscle twitching 25.50 24.45 33 25519 29902 110533845
Disseminated intravascular coagulation 25.47 24.45 39 25513 41247 110522500
Impaired healing 25.39 24.45 7 25545 196710 110367037
Ventricular arrhythmia 25.33 24.45 20 25532 10067 110553680
Increased bronchial secretion 25.15 24.45 14 25538 3934 110559813
Renal injury 24.98 24.45 26 25526 18687 110545060
Priapism 24.87 24.45 16 25536 5845 110557902
Sinus tachycardia 24.64 24.45 40 25512 44453 110519294
Atelectasis 24.54 24.45 36 25516 36676 110527071
Flushing 24.45 24.45 66 25486 104670 110459077

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AC09 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D009465 Neuromuscular Agents
FDA EPC N0000175720 Nondepolarizing Neuromuscular Blocker
FDA PE N0000175732 Neuromuscular Nondepolarizing Blockade
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:51371 muscle relaxant
CHEBI has role CHEBI:51372 neuromuscular agent
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:90753 antidote to organophosphate poisoning
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

M03AC Other quaternary ammonium compounds 10 drugs
atracuriumcisatracuriumdoxacuriumfazadiniumgallaminehexafluroniummivacuriumpancuroniumpipecuroniumvecuronium

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004
General anesthesia indication 50697003
Skeletal Muscle Relaxation for Endotracheal Intubation indication
Respiratory acidosis contraindication 12326000
Alkalosis contraindication 21420006
Acidosis contraindication 51387008
Eaton-Lambert syndrome contraindication 56989000 DOID:0050214
Pulmonary hypertension contraindication 70995007 DOID:6432
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Respiratory alkalosis contraindication 111378004
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Malignant hyperthermia contraindication 405501007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Acetylcholine receptor Ion channel ANTAGONIST IC50 7.77 WOMBAT-PK CHEMBL
Acetylcholine receptor; alpha1/beta1/delta/gamma Ion channel IC50 7.09 CHEMBL

External reference:

IDSource
D00765 KEGG_DRUG
143558-00-3 SECONDARY_CAS_RN
4020866 VANDF
C0209337 UMLSCUI
RBR PDB_CHEM_ID
CHEMBL1201244 ChEMBL_ID
CHEMBL1200648 ChEMBL_ID
D000077123 MESH_DESCRIPTOR_UI
DB00728 DRUGBANK_ID
4003 IUPHAR_LIGAND_ID
WRE554RFEZ UNII
441290 PUBCHEM_CID
151718 RXNORM
1460 MMSL
159147 MMSL
5433 MMSL
d03766 MMSL
004442 NDDF
013418 NDDF
108449002 SNOMEDCT_US
108450002 SNOMEDCT_US
372494005 SNOMEDCT_US
CHEBI:8885 CHEBI
6864 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9250 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9251 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0264-5711 INJECTION 50 mg INTRAVENOUS NDA 25 sections
rocuronium bromide Human Prescription Drug Label 1 0409-1403 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide Human Prescription Drug Label 1 0409-3189 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide Human Prescription Drug Label 1 0409-5160 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide Human Prescription Drug Label 1 0409-7037 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9558 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 29 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9558 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 29 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3220 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 25021-662 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 27 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 25021-687 INJECTION 10 mg INTRAVENOUS ANDA 29 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 39822-4200 SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 42677-309 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 42677-310 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-007 INJECTION 50 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-013 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43547-530 INJECTION 50 mg INTRAVENOUS ANDA 25 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43547-531 INJECTION 100 mg INTRAVENOUS ANDA 25 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1354 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1355 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1545 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1546 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 17 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1640 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1641 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-225 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-226 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 25 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 63323-426 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 63323-426 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
ROCURONIUM BROMIDE Human Prescription Drug Label 1 65145-130 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections