gonadorelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| pituitary hormone-release stimulating peptides | 2958 | 33515-09-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 30, 1982 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Metastases to bone | 122.94 | 56.44 | 31 | 642 | 20988 | 63467361 |
| Neutropenia | 114.97 | 56.44 | 49 | 624 | 174956 | 63313393 |
| Ovarian hyperstimulation syndrome | 103.40 | 56.44 | 20 | 653 | 3994 | 63484355 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Recalled product administered | 68.19 | 37.15 | 10 | 255 | 531 | 34956135 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Metastases to bone | 101.31 | 43.22 | 27 | 754 | 24400 | 79719207 |
| Ovarian hyperstimulation syndrome | 94.63 | 43.22 | 18 | 763 | 3553 | 79740054 |
| Neutropenia | 86.50 | 43.22 | 46 | 735 | 287664 | 79455943 |
| Carcinoembryonic antigen increased | 45.35 | 43.22 | 9 | 772 | 2200 | 79741407 |
| Meningeal disorder | 44.74 | 43.22 | 7 | 774 | 436 | 79743171 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H01CA01 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES HYPOTHALAMIC HORMONES Gonadotropin-releasing hormones |
| ATC | V04CM01 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for fertility disturbances |
| CHEBI has role | CHEBI:63533 | gonadotropin releasing hormone agonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Amenorrhea | indication | 14302001 | DOID:13938 |
| Diagnostic Test for Gonadotropin Deficiency | indication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Reproductive synchrony programs | Indication |
| Cattle | Ovarian cysts | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| CYSTORELIN | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Factrel, Factrel Injection | Zoetis Inc. | 1 |
| Fertelin, OvaCyst | Bimeda Animal Health Limited | 1 |
| FERTAGYL | Intervet Inc. | 1 |
| Gonabreed | Parnell Technologies Pty. Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.65 | acidic |
| pKa2 | 11.9 | acidic |
| pKa3 | 12.71 | acidic |
| pKa4 | 12.88 | acidic |
| pKa5 | 13.24 | acidic |
| pKa6 | 13.32 | acidic |
| pKa7 | 13.61 | acidic |
| pKa8 | 13.97 | acidic |
| pKa9 | 10.75 | Basic |
| pKa10 | 6.69 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | GPCR | AGONIST | IC50 | 8 | CHEMBL | CHEMBL | |||
| Gonadotropin-releasing hormone receptor | GPCR | IC50 | 8.70 | CHEMBL | |||||
| Lutropin-choriogonadotropic hormone receptor | GPCR | Ki | 8.90 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019767 | VUID |
| N0000147858 | NUI |
| D00988 | KEGG_DRUG |
| 51952-41-1 | SECONDARY_CAS_RN |
| 4018487 | VANDF |
| 4018488 | VANDF |
| 4019767 | VANDF |
| C0023610 | UMLSCUI |
| CHEBI:5520 | CHEBI |
| CHEMBL1007 | ChEMBL_ID |
| CHEMBL1200511 | ChEMBL_ID |
| CHEMBL1200516 | ChEMBL_ID |
| DB00644 | DRUGBANK_ID |
| 3627 | INN_ID |
| 52699-48-6 | SECONDARY_CAS_RN |
| 9O7312W37G | UNII |
| 638793 | PUBCHEM_CID |
| 1298838 | RXNORM |
| 4796 | MMSL |
| 4797 | MMSL |
| d00573 | MMSL |
| 002108 | NDDF |
| 002109 | NDDF |
| 004782 | NDDF |
| 008305 | NDDF |
| 008306 | NDDF |
| 325995009 | SNOMEDCT_US |
| 397197007 | SNOMEDCT_US |
| 412193007 | SNOMEDCT_US |
| 49869009 | SNOMEDCT_US |
| 75969007 | SNOMEDCT_US |
| 96365009 | SNOMEDCT_US |
| D007987 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None