Stem definition | Drug id | CAS RN |
---|---|---|
hypnotic tranquillizers | 2873 | 43200-80-2 |
Dose | Unit | Route |
---|---|---|
7.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.12 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.28 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 15, 2004 | FDA | SUNOVION PHARMS INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Lower respiratory tract infection | 697.39 | 11.26 | 828 | 84012 | 94373 | 50425911 |
Intentional overdose | 650.15 | 11.26 | 654 | 84186 | 61850 | 50458434 |
Coma | 572.95 | 11.26 | 585 | 84255 | 56294 | 50463990 |
Intentional self-injury | 561.62 | 11.26 | 395 | 84445 | 22717 | 50497567 |
Muscle spasticity | 458.18 | 11.26 | 311 | 84529 | 16873 | 50503411 |
Folliculitis | 414.17 | 11.26 | 414 | 84426 | 38811 | 50481473 |
Muscle injury | 412.83 | 11.26 | 403 | 84437 | 36708 | 50483576 |
Ear pain | 379.69 | 11.26 | 341 | 84499 | 27942 | 50492342 |
Body temperature increased | 378.22 | 11.26 | 356 | 84484 | 30985 | 50489299 |
Ill-defined disorder | 353.79 | 11.26 | 447 | 84393 | 54207 | 50466077 |
Irritable bowel syndrome | 346.18 | 11.26 | 429 | 84411 | 51012 | 50469272 |
Respiratory disorder | 323.37 | 11.26 | 326 | 84514 | 30861 | 50489423 |
Sinusitis | 310.57 | 11.26 | 800 | 84040 | 169758 | 50350526 |
Night sweats | 284.15 | 11.26 | 315 | 84525 | 33259 | 50487025 |
Pneumonia aspiration | 278.23 | 11.26 | 300 | 84540 | 30704 | 50489580 |
Poisoning deliberate | 269.40 | 11.26 | 167 | 84673 | 7745 | 50512539 |
Impaired healing | 245.98 | 11.26 | 429 | 84411 | 69357 | 50450927 |
Peripheral swelling | 241.16 | 11.26 | 826 | 84014 | 205110 | 50315174 |
Gastrointestinal disorder | 240.89 | 11.26 | 506 | 84334 | 93950 | 50426334 |
Blister | 240.81 | 11.26 | 477 | 84363 | 84941 | 50435343 |
Confusional state | 234.75 | 11.26 | 765 | 84075 | 185163 | 50335121 |
Somnolence | 226.43 | 11.26 | 671 | 84169 | 154314 | 50365970 |
Stomatitis | 185.86 | 11.26 | 477 | 84363 | 100867 | 50419417 |
Pruritus | 183.03 | 11.26 | 948 | 83892 | 282620 | 50237664 |
Product dose omission issue | 177.03 | 11.26 | 45 | 84795 | 183793 | 50336491 |
Sleep disorder due to general medical condition, insomnia type | 160.24 | 11.26 | 229 | 84611 | 31218 | 50489066 |
Insomnia | 158.29 | 11.26 | 646 | 84194 | 174219 | 50346065 |
Joint swelling | 147.87 | 11.26 | 805 | 84035 | 244481 | 50275803 |
Nasopharyngitis | 145.77 | 11.26 | 675 | 84165 | 192252 | 50328032 |
Schizoaffective disorder | 139.57 | 11.26 | 70 | 84770 | 2136 | 50518148 |
Urticaria | 130.39 | 11.26 | 495 | 84345 | 129066 | 50391218 |
Death | 118.33 | 11.26 | 229 | 84611 | 325150 | 50195134 |
Electric shock | 116.76 | 11.26 | 49 | 84791 | 979 | 50519305 |
Electrocardiogram QT prolonged | 112.94 | 11.26 | 261 | 84579 | 51625 | 50468659 |
Toxicity to various agents | 111.30 | 11.26 | 672 | 84168 | 211827 | 50308457 |
Sleep disorder | 110.54 | 11.26 | 275 | 84565 | 57008 | 50463276 |
Weight increased | 105.43 | 11.26 | 638 | 84202 | 201253 | 50319031 |
Akathisia | 102.14 | 11.26 | 95 | 84745 | 8134 | 50512150 |
Cardiac failure congestive | 99.96 | 11.26 | 12 | 84828 | 84370 | 50435914 |
Therapeutic product effect decreased | 95.36 | 11.26 | 466 | 84374 | 135584 | 50384700 |
Drug hypersensitivity | 78.47 | 11.26 | 192 | 84648 | 250818 | 50269466 |
Prescription form tampering | 77.93 | 11.26 | 31 | 84809 | 537 | 50519747 |
Depressed level of consciousness | 76.70 | 11.26 | 226 | 84614 | 51727 | 50468557 |
Suicide attempt | 76.34 | 11.26 | 225 | 84615 | 51507 | 50468777 |
Infection | 74.00 | 11.26 | 520 | 84320 | 172434 | 50347850 |
Intervertebral discitis | 70.59 | 11.26 | 48 | 84792 | 2608 | 50517676 |
Drug dependence | 68.92 | 11.26 | 121 | 84719 | 19638 | 50500646 |
Antipsychotic drug level increased | 68.27 | 11.26 | 50 | 84790 | 3059 | 50517225 |
Post-traumatic stress disorder | 68.05 | 11.26 | 57 | 84783 | 4246 | 50516038 |
Neovascularisation | 66.61 | 11.26 | 33 | 84807 | 980 | 50519304 |
Injection site pain | 62.97 | 11.26 | 56 | 84784 | 110968 | 50409316 |
Hepatocellular injury | 60.31 | 11.26 | 134 | 84706 | 25813 | 50494471 |
Miosis | 60.01 | 11.26 | 63 | 84777 | 6247 | 50514037 |
Drug level increased | 55.90 | 11.26 | 109 | 84731 | 19159 | 50501125 |
Abdominal pain upper | 55.22 | 11.26 | 456 | 84384 | 158853 | 50361431 |
Back pain | 52.54 | 11.26 | 582 | 84258 | 219448 | 50300836 |
Drug ineffective | 52.29 | 11.26 | 1015 | 83825 | 818318 | 49701966 |
Sepsis | 51.35 | 11.26 | 90 | 84750 | 132835 | 50387449 |
Lupus vasculitis | 51.28 | 11.26 | 22 | 84818 | 465 | 50519819 |
Somnambulism | 50.14 | 11.26 | 51 | 84789 | 4873 | 50515411 |
Fluid retention | 49.46 | 11.26 | 12 | 84828 | 50637 | 50469647 |
Mydriasis | 49.21 | 11.26 | 74 | 84766 | 10553 | 50509731 |
Gastrooesophageal reflux disease | 48.03 | 11.26 | 254 | 84586 | 76174 | 50444110 |
Skin candida | 47.71 | 11.26 | 29 | 84811 | 1297 | 50518987 |
Respiratory failure | 47.05 | 11.26 | 50 | 84790 | 91131 | 50429153 |
Bronchial wall thickening | 46.57 | 11.26 | 25 | 84815 | 880 | 50519404 |
Broncholithiasis | 45.45 | 11.26 | 15 | 84825 | 147 | 50520137 |
Demyelination | 43.31 | 11.26 | 52 | 84788 | 5974 | 50514310 |
Maternal exposure during pregnancy | 43.28 | 11.26 | 131 | 84709 | 159647 | 50360637 |
Exposure during pregnancy | 43.15 | 11.26 | 86 | 84754 | 120929 | 50399355 |
Pneumonia | 43.13 | 11.26 | 416 | 84424 | 377985 | 50142299 |
Sputum discoloured | 42.85 | 11.26 | 79 | 84761 | 13316 | 50506968 |
Sinus rhythm | 42.53 | 11.26 | 21 | 84819 | 619 | 50519665 |
Myocardial infarction | 40.41 | 11.26 | 54 | 84786 | 88973 | 50431311 |
Obstructive airways disorder | 40.00 | 11.26 | 84 | 84756 | 15568 | 50504716 |
Injection site erythema | 39.90 | 11.26 | 40 | 84800 | 74896 | 50445388 |
Contusion | 39.86 | 11.26 | 323 | 84517 | 111860 | 50408424 |
Lymph node calcification | 39.80 | 11.26 | 15 | 84825 | 223 | 50520061 |
Cerebrovascular accident | 39.45 | 11.26 | 61 | 84779 | 94619 | 50425665 |
Rash | 39.29 | 11.26 | 985 | 83855 | 436486 | 50083798 |
Abortion spontaneous | 38.69 | 11.26 | 11 | 84829 | 41761 | 50478523 |
Alopecia | 38.32 | 11.26 | 247 | 84593 | 244800 | 50275484 |
Injection site reaction | 38.20 | 11.26 | 18 | 84822 | 50014 | 50470270 |
Wrong technique in product usage process | 37.94 | 11.26 | 23 | 84817 | 55487 | 50464797 |
Unevaluable event | 37.67 | 11.26 | 15 | 84825 | 46051 | 50474233 |
White blood cell count decreased | 37.43 | 11.26 | 88 | 84752 | 116634 | 50403650 |
Swelling | 37.36 | 11.26 | 507 | 84333 | 200365 | 50319919 |
Temperature intolerance | 37.07 | 11.26 | 54 | 84786 | 7485 | 50512799 |
Pain in extremity | 35.44 | 11.26 | 290 | 84550 | 272575 | 50247709 |
Cholestasis | 35.12 | 11.26 | 108 | 84732 | 25293 | 50494991 |
Excessive eye blinking | 34.84 | 11.26 | 21 | 84819 | 925 | 50519359 |
Calcium deficiency | 34.76 | 11.26 | 21 | 84819 | 929 | 50519355 |
Platelet count decreased | 34.70 | 11.26 | 73 | 84767 | 100653 | 50419631 |
Asphyxia | 34.45 | 11.26 | 44 | 84796 | 5383 | 50514901 |
Product quality issue | 32.82 | 11.26 | 6 | 84834 | 30852 | 50489432 |
Hyponatraemia | 32.64 | 11.26 | 274 | 84566 | 95865 | 50424419 |
Depressed mood | 32.53 | 11.26 | 128 | 84712 | 33895 | 50486389 |
Injection site bruising | 31.70 | 11.26 | 11 | 84829 | 36757 | 50483527 |
Post-traumatic neck syndrome | 31.66 | 11.26 | 26 | 84814 | 1884 | 50518400 |
Hospitalisation | 31.04 | 11.26 | 41 | 84799 | 67896 | 50452388 |
Rheumatoid factor positive | 30.93 | 11.26 | 23 | 84817 | 49836 | 50470448 |
Pyrexia | 30.89 | 11.26 | 845 | 83995 | 379358 | 50140926 |
Postmortem blood drug level abnormal | 30.70 | 11.26 | 14 | 84826 | 344 | 50519940 |
Pulmonary hypertension | 30.58 | 11.26 | 9 | 84831 | 33408 | 50486876 |
C-reactive protein abnormal | 30.47 | 11.26 | 5 | 84835 | 27804 | 50492480 |
Paradoxical drug reaction | 30.45 | 11.26 | 34 | 84806 | 3613 | 50516671 |
Helicobacter infection | 30.41 | 11.26 | 164 | 84676 | 49538 | 50470746 |
Injection site pruritus | 30.15 | 11.26 | 15 | 84825 | 40396 | 50479888 |
Therapy cessation | 30.06 | 11.26 | 4 | 84836 | 26007 | 50494277 |
Condition aggravated | 29.95 | 11.26 | 336 | 84504 | 296722 | 50223562 |
Progressive multifocal leukoencephalopathy | 29.87 | 11.26 | 62 | 84778 | 11395 | 50508889 |
Blood glucose increased | 29.66 | 11.26 | 46 | 84794 | 71278 | 50449006 |
Libido increased | 29.60 | 11.26 | 21 | 84819 | 1222 | 50519062 |
Mobility decreased | 29.20 | 11.26 | 56 | 84784 | 79892 | 50440392 |
Nausea | 29.03 | 11.26 | 932 | 83908 | 704466 | 49815818 |
No adverse event | 29.03 | 11.26 | 10 | 84830 | 33568 | 50486716 |
Atrial fibrillation | 28.56 | 11.26 | 82 | 84758 | 101663 | 50418621 |
Soft tissue injury | 28.44 | 11.26 | 22 | 84818 | 1462 | 50518822 |
COVID-19 | 28.34 | 11.26 | 22 | 84818 | 46640 | 50473644 |
Concussion | 28.28 | 11.26 | 48 | 84792 | 7580 | 50512704 |
Treatment failure | 27.98 | 11.26 | 127 | 84713 | 137510 | 50382774 |
Chronic kidney disease | 27.86 | 11.26 | 16 | 84824 | 39755 | 50480529 |
Completed suicide | 27.83 | 11.26 | 120 | 84720 | 131769 | 50388515 |
Vocal cord dysfunction | 27.38 | 11.26 | 13 | 84827 | 351 | 50519933 |
Coronary artery disease | 27.21 | 11.26 | 8 | 84832 | 29718 | 50490566 |
Disease progression | 27.10 | 11.26 | 77 | 84763 | 95789 | 50424495 |
Hostility | 26.93 | 11.26 | 23 | 84817 | 1759 | 50518525 |
Duodenal ulcer perforation | 26.89 | 11.26 | 149 | 84691 | 45462 | 50474822 |
Liver function test abnormal | 26.81 | 11.26 | 21 | 84819 | 44318 | 50475966 |
Gallbladder adenocarcinoma | 26.76 | 11.26 | 9 | 84831 | 94 | 50520190 |
Altered state of consciousness | 26.51 | 11.26 | 89 | 84751 | 21821 | 50498463 |
Thrombosis | 26.22 | 11.26 | 33 | 84807 | 55800 | 50464484 |
Urine leukocyte esterase positive | 26.02 | 11.26 | 28 | 84812 | 2855 | 50517429 |
Abdominal discomfort | 25.77 | 11.26 | 256 | 84584 | 231385 | 50288899 |
Blood creatinine increased | 25.56 | 11.26 | 56 | 84784 | 76104 | 50444180 |
Urine abnormality | 25.48 | 11.26 | 41 | 84799 | 6197 | 50514087 |
Overdose | 25.23 | 11.26 | 267 | 84573 | 99460 | 50420824 |
Diabetes mellitus | 25.16 | 11.26 | 27 | 84813 | 49006 | 50471278 |
Lupus nephritis | 25.09 | 11.26 | 25 | 84815 | 2330 | 50517954 |
Coordination abnormal | 25.06 | 11.26 | 58 | 84782 | 11476 | 50508808 |
Diaphragmatic rupture | 24.99 | 11.26 | 11 | 84829 | 248 | 50520036 |
Hypervolaemia | 24.98 | 11.26 | 6 | 84834 | 25493 | 50494791 |
Oedema | 24.90 | 11.26 | 50 | 84790 | 70131 | 50450153 |
Behaviour disorder | 24.87 | 11.26 | 25 | 84815 | 2355 | 50517929 |
Neutropenia | 24.73 | 11.26 | 146 | 84694 | 147819 | 50372465 |
Renal failure | 24.39 | 11.26 | 94 | 84746 | 106539 | 50413745 |
Distal intestinal obstruction syndrome | 24.33 | 11.26 | 12 | 84828 | 353 | 50519931 |
Postmortem blood drug level increased | 24.27 | 11.26 | 14 | 84826 | 568 | 50519716 |
Drug intolerance | 24.01 | 11.26 | 243 | 84597 | 218861 | 50301423 |
Adrenal insufficiency | 23.98 | 11.26 | 65 | 84775 | 14178 | 50506106 |
Antidepressant drug level above therapeutic | 23.78 | 11.26 | 12 | 84828 | 371 | 50519913 |
Injection site swelling | 23.75 | 11.26 | 21 | 84819 | 41752 | 50478532 |
Feeling abnormal | 23.63 | 11.26 | 119 | 84721 | 125373 | 50394911 |
Gait disturbance | 23.52 | 11.26 | 151 | 84689 | 149854 | 50370430 |
Dyspnoea exertional | 23.32 | 11.26 | 31 | 84809 | 51202 | 50469082 |
Extrapyramidal disorder | 23.21 | 11.26 | 57 | 84783 | 11713 | 50508571 |
Red blood cells urine | 23.17 | 11.26 | 13 | 84827 | 500 | 50519784 |
White blood cells urine positive | 22.81 | 11.26 | 33 | 84807 | 4545 | 50515739 |
Suicidal ideation | 22.75 | 11.26 | 165 | 84675 | 55220 | 50465064 |
Hypocoagulable state | 22.72 | 11.26 | 16 | 84824 | 920 | 50519364 |
Blood creatine increased | 22.58 | 11.26 | 34 | 84806 | 4853 | 50515431 |
Hypothermia | 22.44 | 11.26 | 57 | 84783 | 11959 | 50508325 |
Hypertension | 22.42 | 11.26 | 236 | 84604 | 210967 | 50309317 |
Neoplasm malignant | 22.42 | 11.26 | 6 | 84834 | 23709 | 50496575 |
Full blood count decreased | 22.40 | 11.26 | 5 | 84835 | 22341 | 50497943 |
Cellulitis | 22.19 | 11.26 | 54 | 84786 | 70744 | 50449540 |
Deep vein thrombosis | 22.13 | 11.26 | 57 | 84783 | 73247 | 50447037 |
Psoriatic arthropathy | 21.88 | 11.26 | 28 | 84812 | 47004 | 50473280 |
Balance disorder | 21.77 | 11.26 | 197 | 84643 | 70393 | 50449891 |
Malignant polyp | 21.58 | 11.26 | 9 | 84831 | 177 | 50520107 |
Hypersensitivity | 21.53 | 11.26 | 492 | 84348 | 214669 | 50305615 |
Negative thoughts | 21.48 | 11.26 | 15 | 84825 | 851 | 50519433 |
Renal impairment | 21.21 | 11.26 | 61 | 84779 | 75600 | 50444684 |
Monocyte percentage increased | 21.20 | 11.26 | 16 | 84824 | 1025 | 50519259 |
Haematocrit increased | 21.11 | 11.26 | 21 | 84819 | 1953 | 50518331 |
Burnout syndrome | 21.08 | 11.26 | 9 | 84831 | 188 | 50520096 |
Nightmare | 20.95 | 11.26 | 67 | 84773 | 16019 | 50504265 |
Sternal fracture | 20.87 | 11.26 | 21 | 84819 | 1981 | 50518303 |
Sopor | 20.85 | 11.26 | 4 | 84836 | 19875 | 50500409 |
Toxicologic test abnormal | 20.82 | 11.26 | 13 | 84827 | 610 | 50519674 |
Drug level above therapeutic | 20.63 | 11.26 | 29 | 84811 | 3891 | 50516393 |
Disturbance in attention | 20.51 | 11.26 | 105 | 84735 | 31081 | 50489203 |
Adverse event | 20.41 | 11.26 | 26 | 84814 | 43737 | 50476547 |
Knee arthroplasty | 20.41 | 11.26 | 18 | 84822 | 35828 | 50484456 |
Chest pain | 20.29 | 11.26 | 194 | 84646 | 176688 | 50343596 |
Hallucination, synaesthetic | 20.20 | 11.26 | 6 | 84834 | 40 | 50520244 |
Staphylococcal infection | 20.14 | 11.26 | 18 | 84822 | 35598 | 50484686 |
Antipsychotic drug level above therapeutic | 20.11 | 11.26 | 15 | 84825 | 944 | 50519340 |
Hypersensitivity vasculitis | 20.09 | 11.26 | 29 | 84811 | 3986 | 50516298 |
Urinary tract infection | 20.03 | 11.26 | 260 | 84580 | 223760 | 50296524 |
Carcinoid tumour pulmonary | 19.87 | 11.26 | 11 | 84829 | 412 | 50519872 |
Incorrect route of product administration | 19.30 | 11.26 | 72 | 84768 | 18594 | 50501690 |
Loss of personal independence in daily activities | 19.26 | 11.26 | 57 | 84783 | 69993 | 50450291 |
Poor feeding infant | 19.23 | 11.26 | 9 | 84831 | 235 | 50520049 |
Wrong rate | 19.04 | 11.26 | 6 | 84834 | 50 | 50520234 |
Lactic acidosis | 19.02 | 11.26 | 108 | 84732 | 33247 | 50487037 |
Contraindicated product administered | 18.96 | 11.26 | 353 | 84487 | 148605 | 50371679 |
Eye irritation | 18.96 | 11.26 | 3 | 84837 | 17137 | 50503147 |
Seizure | 18.81 | 11.26 | 118 | 84722 | 117756 | 50402528 |
Pain | 18.71 | 11.26 | 1166 | 83674 | 577737 | 49942547 |
Neutropenic sepsis | 18.49 | 11.26 | 59 | 84781 | 14088 | 50506196 |
Middle insomnia | 18.46 | 11.26 | 47 | 84793 | 9874 | 50510410 |
Inappropriate antidiuretic hormone secretion | 18.28 | 11.26 | 56 | 84784 | 13087 | 50507197 |
Ligament pain | 18.11 | 11.26 | 8 | 84832 | 182 | 50520102 |
Haemoglobin urine | 18.05 | 11.26 | 7 | 84833 | 113 | 50520171 |
Cytomegalovirus infection | 18.04 | 11.26 | 4 | 84836 | 17958 | 50502326 |
Laryngeal stenosis | 17.91 | 11.26 | 13 | 84827 | 784 | 50519500 |
Bronchiolitis | 17.86 | 11.26 | 21 | 84819 | 2360 | 50517924 |
Gait deviation | 17.81 | 11.26 | 6 | 84834 | 63 | 50520221 |
Procedural anxiety | 17.71 | 11.26 | 12 | 84828 | 648 | 50519636 |
Tooth hypoplasia | 17.64 | 11.26 | 6 | 84834 | 65 | 50520219 |
Bulimia nervosa | 17.53 | 11.26 | 10 | 84830 | 397 | 50519887 |
Myocarditis septic | 17.28 | 11.26 | 5 | 84835 | 30 | 50520254 |
Myelocyte percentage increased | 17.20 | 11.26 | 8 | 84832 | 206 | 50520078 |
Peripheral circulatory failure | 16.98 | 11.26 | 11 | 84829 | 551 | 50519733 |
Band neutrophil percentage increased | 16.95 | 11.26 | 8 | 84832 | 213 | 50520071 |
Product monitoring error | 16.90 | 11.26 | 22 | 84818 | 2742 | 50517542 |
Housebound | 16.78 | 11.26 | 8 | 84832 | 218 | 50520066 |
Adverse drug reaction | 16.62 | 11.26 | 43 | 84797 | 55179 | 50465105 |
Presyncope | 16.57 | 11.26 | 10 | 84830 | 24188 | 50496096 |
Newborn persistent pulmonary hypertension | 16.54 | 11.26 | 7 | 84833 | 143 | 50520141 |
Cardiac arrest | 16.51 | 11.26 | 78 | 84762 | 83573 | 50436711 |
Drug detoxification | 16.49 | 11.26 | 7 | 84833 | 144 | 50520140 |
Granulomatous liver disease | 16.43 | 11.26 | 12 | 84828 | 731 | 50519553 |
Urine oxalate increased | 16.42 | 11.26 | 8 | 84832 | 229 | 50520055 |
Crystal urine present | 16.36 | 11.26 | 16 | 84824 | 1458 | 50518826 |
Plasma cell myeloma | 16.35 | 11.26 | 17 | 84823 | 31305 | 50488979 |
Granulocyte count increased | 16.30 | 11.26 | 10 | 84830 | 455 | 50519829 |
Gallbladder disorder | 16.28 | 11.26 | 4 | 84836 | 16738 | 50503546 |
Proctitis | 16.14 | 11.26 | 18 | 84822 | 1910 | 50518374 |
Antibody test abnormal | 16.10 | 11.26 | 10 | 84830 | 465 | 50519819 |
Vaginal flatulence | 15.95 | 11.26 | 8 | 84832 | 244 | 50520040 |
Mixed liver injury | 15.93 | 11.26 | 24 | 84816 | 3427 | 50516857 |
Urinary tract obstruction | 15.82 | 11.26 | 17 | 84823 | 1731 | 50518553 |
Accommodation disorder | 15.81 | 11.26 | 9 | 84831 | 356 | 50519928 |
Diabetic hyperosmolar coma | 15.72 | 11.26 | 9 | 84831 | 360 | 50519924 |
Dyspnoea | 15.70 | 11.26 | 1092 | 83748 | 546516 | 49973768 |
Medication error | 15.66 | 11.26 | 109 | 84731 | 35995 | 50484289 |
Victim of chemical submission | 15.63 | 11.26 | 8 | 84832 | 255 | 50520029 |
Therapeutic response decreased | 15.62 | 11.26 | 35 | 84805 | 47196 | 50473088 |
Agitation neonatal | 15.57 | 11.26 | 10 | 84830 | 493 | 50519791 |
Cholelithiasis | 15.30 | 11.26 | 25 | 84815 | 37948 | 50482336 |
Bronchopulmonary aspergillosis allergic | 15.26 | 11.26 | 14 | 84826 | 1177 | 50519107 |
Accidental exposure to product | 15.14 | 11.26 | 10 | 84830 | 23047 | 50497237 |
Occult blood | 15.10 | 11.26 | 14 | 84826 | 1193 | 50519091 |
Retinal depigmentation | 15.10 | 11.26 | 8 | 84832 | 274 | 50520010 |
Surgery | 15.09 | 11.26 | 17 | 84823 | 30188 | 50490096 |
Neuroleptic malignant syndrome | 15.08 | 11.26 | 47 | 84793 | 11083 | 50509201 |
Right ventricular failure | 15.06 | 11.26 | 4 | 84836 | 15889 | 50504395 |
Psychotic symptom | 15.05 | 11.26 | 14 | 84826 | 1198 | 50519086 |
Psoriasis | 15.03 | 11.26 | 62 | 84778 | 68938 | 50451346 |
Drug abuse | 15.02 | 11.26 | 160 | 84680 | 59686 | 50460598 |
Drug reaction with eosinophilia and systemic symptoms | 14.89 | 11.26 | 90 | 84750 | 28334 | 50491950 |
Neutrophil count increased | 14.88 | 11.26 | 55 | 84785 | 14140 | 50506144 |
Atelectasis | 14.85 | 11.26 | 6 | 84834 | 18264 | 50502020 |
Aspartate aminotransferase increased | 14.65 | 11.26 | 74 | 84766 | 77924 | 50442360 |
Sensory level abnormal | 14.62 | 11.26 | 6 | 84834 | 113 | 50520171 |
Device dislocation | 14.62 | 11.26 | 9 | 84831 | 21537 | 50498747 |
Osteonecrosis | 14.47 | 11.26 | 10 | 84830 | 22507 | 50497777 |
Foetal death | 14.45 | 11.26 | 38 | 84802 | 8142 | 50512142 |
Therapeutic product effect incomplete | 14.40 | 11.26 | 92 | 84748 | 91423 | 50428861 |
Tri-iodothyronine free decreased | 14.39 | 11.26 | 8 | 84832 | 302 | 50519982 |
Vaginal haemorrhage | 14.37 | 11.26 | 12 | 84828 | 24539 | 50495745 |
Total lung capacity decreased | 14.30 | 11.26 | 14 | 84826 | 1277 | 50519007 |
Failed induction of labour | 14.27 | 11.26 | 8 | 84832 | 307 | 50519977 |
Osteomyelitis | 14.27 | 11.26 | 10 | 84830 | 22343 | 50497941 |
Pulmonary function test abnormal | 14.12 | 11.26 | 14 | 84826 | 1297 | 50518987 |
Chest wall mass | 14.09 | 11.26 | 5 | 84835 | 62 | 50520222 |
Procedural pain | 14.06 | 11.26 | 3 | 84837 | 13829 | 50506455 |
Glucocorticoids increased | 14.02 | 11.26 | 6 | 84834 | 126 | 50520158 |
Urinary sediment present | 14.01 | 11.26 | 17 | 84823 | 1974 | 50518310 |
Post procedural complication | 13.94 | 11.26 | 4 | 84836 | 15100 | 50505184 |
Multiple organ dysfunction syndrome | 13.80 | 11.26 | 41 | 84799 | 50296 | 50469988 |
Bezoar | 13.79 | 11.26 | 14 | 84826 | 1334 | 50518950 |
Infusion site scar | 13.79 | 11.26 | 8 | 84832 | 328 | 50519956 |
Anaemia | 13.55 | 11.26 | 321 | 84519 | 252135 | 50268149 |
Band neutrophil count increased | 13.47 | 11.26 | 8 | 84832 | 343 | 50519941 |
Menopause | 13.43 | 11.26 | 18 | 84822 | 2309 | 50517975 |
Myelocyte count increased | 13.42 | 11.26 | 8 | 84832 | 345 | 50519939 |
Poor venous access | 13.40 | 11.26 | 43 | 84797 | 10297 | 50509987 |
Urine ketone body present | 13.39 | 11.26 | 18 | 84822 | 2315 | 50517969 |
Ureteric obstruction | 13.29 | 11.26 | 15 | 84825 | 1613 | 50518671 |
Hallucination | 13.28 | 11.26 | 128 | 84712 | 46529 | 50473755 |
Electrocardiogram repolarisation abnormality | 13.27 | 11.26 | 13 | 84827 | 1187 | 50519097 |
Blood urea increased | 13.24 | 11.26 | 12 | 84828 | 23573 | 50496711 |
Transient ischaemic attack | 13.17 | 11.26 | 21 | 84819 | 32189 | 50488095 |
Pancreatic carcinoma recurrent | 13.05 | 11.26 | 5 | 84835 | 78 | 50520206 |
Distributive shock | 13.02 | 11.26 | 11 | 84829 | 829 | 50519455 |
Anuria | 13.01 | 11.26 | 45 | 84795 | 11199 | 50509085 |
Anticonvulsant drug level above therapeutic | 12.99 | 11.26 | 9 | 84831 | 504 | 50519780 |
Haemorrhage | 12.94 | 11.26 | 46 | 84794 | 53395 | 50466889 |
Macular degeneration | 12.94 | 11.26 | 4 | 84836 | 14384 | 50505900 |
Cholinergic syndrome | 12.84 | 11.26 | 8 | 84832 | 374 | 50519910 |
Pharyngeal paraesthesia | 12.79 | 11.26 | 14 | 84826 | 1455 | 50518829 |
Drug resistance | 12.79 | 11.26 | 8 | 84832 | 18981 | 50501303 |
Hypoaesthesia | 12.77 | 11.26 | 144 | 84696 | 127113 | 50393171 |
Pulmonary embolism | 12.76 | 11.26 | 109 | 84731 | 101595 | 50418689 |
Product prescribing error | 12.70 | 11.26 | 69 | 84771 | 20892 | 50499392 |
Device issue | 12.66 | 11.26 | 9 | 84831 | 19963 | 50500321 |
Lymphadenopathy | 12.64 | 11.26 | 23 | 84817 | 33476 | 50486808 |
Eczema | 12.61 | 11.26 | 73 | 84767 | 22629 | 50497655 |
Social anxiety disorder | 12.49 | 11.26 | 8 | 84832 | 393 | 50519891 |
Dysarthria | 12.37 | 11.26 | 106 | 84734 | 37297 | 50482987 |
Throat irritation | 12.36 | 11.26 | 90 | 84750 | 30149 | 50490135 |
Liver injury | 12.35 | 11.26 | 14 | 84826 | 24792 | 50495492 |
Alanine aminotransferase increased | 12.33 | 11.26 | 92 | 84748 | 88267 | 50432017 |
Substance use disorder | 12.24 | 11.26 | 5 | 84835 | 93 | 50520191 |
Red blood cell sedimentation rate increased | 12.20 | 11.26 | 19 | 84821 | 29397 | 50490887 |
Multiple sclerosis | 12.11 | 11.26 | 67 | 84773 | 20426 | 50499858 |
Fibromyalgia | 12.07 | 11.26 | 37 | 84803 | 44941 | 50475343 |
Arthralgia | 12.06 | 11.26 | 872 | 83968 | 437830 | 50082454 |
Decreased appetite | 12.05 | 11.26 | 251 | 84589 | 200672 | 50319612 |
Blood pressure systolic increased | 12.00 | 11.26 | 101 | 84739 | 35348 | 50484936 |
Electrocardiogram QRS complex shortened | 11.91 | 11.26 | 8 | 84832 | 426 | 50519858 |
Swollen joint count increased | 11.90 | 11.26 | 5 | 84835 | 14868 | 50505416 |
Musculoskeletal stiffness | 11.89 | 11.26 | 148 | 84692 | 128333 | 50391951 |
Fungal infection | 11.82 | 11.26 | 20 | 84820 | 29945 | 50490339 |
Drug diversion | 11.82 | 11.26 | 10 | 84830 | 755 | 50519529 |
Arthritis | 11.77 | 11.26 | 91 | 84749 | 86630 | 50433654 |
Angina pectoris | 11.76 | 11.26 | 16 | 84824 | 26172 | 50494112 |
Ataxia | 11.70 | 11.26 | 50 | 84790 | 13736 | 50506548 |
Respiratory acidosis | 11.68 | 11.26 | 29 | 84811 | 5999 | 50514285 |
Nodule | 11.68 | 11.26 | 7 | 84833 | 16996 | 50503288 |
Bladder dilatation | 11.67 | 11.26 | 10 | 84830 | 768 | 50519516 |
Mass | 11.64 | 11.26 | 3 | 84837 | 12154 | 50508130 |
Anaphylactic reaction | 11.50 | 11.26 | 49 | 84791 | 54006 | 50466278 |
Coagulopathy | 11.49 | 11.26 | 8 | 84832 | 17936 | 50502348 |
Intentional product use issue | 11.47 | 11.26 | 187 | 84653 | 76731 | 50443553 |
Complement factor C4 decreased | 11.45 | 11.26 | 6 | 84834 | 201 | 50520083 |
Meningitis herpes | 11.42 | 11.26 | 6 | 84834 | 202 | 50520082 |
Hip arthroplasty | 11.38 | 11.26 | 21 | 84819 | 30408 | 50489876 |
Cutaneous lupus erythematosus | 11.36 | 11.26 | 17 | 84823 | 2414 | 50517870 |
Heart rate decreased | 11.32 | 11.26 | 102 | 84738 | 36395 | 50483889 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Depression | 705.06 | 11.71 | 672 | 34540 | 84475 | 29454840 |
Drug interaction | 508.19 | 11.71 | 869 | 34343 | 196516 | 29342799 |
Coma | 324.84 | 11.71 | 311 | 34901 | 39139 | 29500176 |
Poisoning deliberate | 272.04 | 11.71 | 134 | 35078 | 5597 | 29533718 |
Intentional overdose | 177.54 | 11.71 | 224 | 34988 | 38304 | 29501011 |
Loss of personal independence in daily activities | 140.18 | 11.71 | 162 | 35050 | 25278 | 29514037 |
Somnolence | 133.07 | 11.71 | 324 | 34888 | 93631 | 29445684 |
Toxicity to various agents | 132.09 | 11.71 | 480 | 34732 | 173181 | 29366134 |
Suicide attempt | 117.13 | 11.71 | 172 | 35040 | 33938 | 29505377 |
Intentional self-injury | 107.66 | 11.71 | 101 | 35111 | 12360 | 29526955 |
Hypothermia | 99.88 | 11.71 | 85 | 35127 | 9154 | 29530161 |
Drug dependence | 93.44 | 11.71 | 120 | 35092 | 20861 | 29518454 |
Miosis | 89.28 | 11.71 | 75 | 35137 | 7934 | 29531381 |
Prescription form tampering | 87.17 | 11.71 | 29 | 35183 | 423 | 29538892 |
Hepatocellular injury | 83.05 | 11.71 | 114 | 35098 | 21129 | 29518186 |
Electrocardiogram QT prolonged | 76.79 | 11.71 | 147 | 35065 | 35990 | 29503325 |
Neuroleptic malignant syndrome | 66.68 | 11.71 | 89 | 35123 | 16059 | 29523256 |
Blood mercury abnormal | 63.81 | 11.71 | 19 | 35193 | 188 | 29539127 |
Confusional state | 63.75 | 11.71 | 311 | 34901 | 127566 | 29411749 |
Overdose | 62.47 | 11.71 | 223 | 34989 | 79596 | 29459719 |
5-hydroxyindolacetic acid in urine increased | 61.67 | 11.71 | 19 | 35193 | 213 | 29539102 |
Low density lipoprotein decreased | 57.97 | 11.71 | 27 | 35185 | 993 | 29538322 |
Housebound | 53.32 | 11.71 | 17 | 35195 | 215 | 29539100 |
Cerebral artery thrombosis | 52.86 | 11.71 | 23 | 35189 | 719 | 29538596 |
Disease progression | 52.70 | 11.71 | 16 | 35196 | 81900 | 29457415 |
Product dose omission issue | 48.80 | 11.71 | 27 | 35185 | 96356 | 29442959 |
Dystonic tremor | 47.61 | 11.71 | 15 | 35197 | 182 | 29539133 |
Myocardial infarction | 47.58 | 11.71 | 37 | 35175 | 110259 | 29429056 |
Brain scan abnormal | 46.76 | 11.71 | 22 | 35190 | 828 | 29538487 |
Suicidal ideation | 46.15 | 11.71 | 117 | 35095 | 34599 | 29504716 |
Cardiac failure congestive | 44.05 | 11.71 | 18 | 35194 | 76563 | 29462752 |
Altered state of consciousness | 43.58 | 11.71 | 82 | 35130 | 19807 | 29519508 |
Fall | 42.08 | 11.71 | 357 | 34855 | 176821 | 29362494 |
Withdrawal syndrome | 38.52 | 11.71 | 56 | 35156 | 10936 | 29528379 |
Macrophages increased | 36.85 | 11.71 | 12 | 35200 | 163 | 29539152 |
Bradypnoea | 36.80 | 11.71 | 27 | 35185 | 2344 | 29536971 |
Drug abuse | 36.72 | 11.71 | 190 | 35022 | 79693 | 29459622 |
Cholestasis | 36.46 | 11.71 | 84 | 35128 | 23378 | 29515937 |
Agitation | 35.64 | 11.71 | 138 | 35074 | 51166 | 29488149 |
Logorrhoea | 35.39 | 11.71 | 26 | 35186 | 2262 | 29537053 |
Asphyxia | 34.68 | 11.71 | 37 | 35175 | 5278 | 29534037 |
Thrombosis | 34.64 | 11.71 | 5 | 35207 | 43040 | 29496275 |
Hyperthermia | 34.45 | 11.71 | 49 | 35163 | 9381 | 29529934 |
Agranulocytosis | 34.04 | 11.71 | 75 | 35137 | 20265 | 29519050 |
Serum ferritin abnormal | 33.54 | 11.71 | 12 | 35200 | 220 | 29539095 |
Toxic skin eruption | 31.74 | 11.71 | 48 | 35164 | 9709 | 29529606 |
Pneumonia aspiration | 31.62 | 11.71 | 106 | 35106 | 36631 | 29502684 |
Implant site extravasation | 30.72 | 11.71 | 13 | 35199 | 379 | 29538936 |
Mental status changes | 30.72 | 11.71 | 3 | 35209 | 34924 | 29504391 |
Drug intolerance | 30.29 | 11.71 | 126 | 35086 | 48253 | 29491062 |
Contraindicated product administered | 30.16 | 11.71 | 67 | 35145 | 18199 | 29521116 |
Puncture site haematoma | 30.05 | 11.71 | 10 | 35202 | 146 | 29539169 |
Restless legs syndrome | 29.60 | 11.71 | 39 | 35173 | 6945 | 29532370 |
Hepatic neoplasm | 28.70 | 11.71 | 21 | 35191 | 1815 | 29537500 |
General physical health deterioration | 28.59 | 11.71 | 215 | 34997 | 102642 | 29436673 |
Tremor | 28.48 | 11.71 | 167 | 35045 | 73371 | 29465944 |
Gastrointestinal haemorrhage | 28.03 | 11.71 | 32 | 35180 | 79501 | 29459814 |
Rheumatoid arthritis | 27.88 | 11.71 | 93 | 35119 | 32059 | 29507256 |
Bladder dilatation | 27.61 | 11.71 | 18 | 35194 | 1290 | 29538025 |
Dystonia | 27.60 | 11.71 | 45 | 35167 | 9704 | 29529611 |
Faecaloma | 26.97 | 11.71 | 29 | 35183 | 4173 | 29535142 |
Overlap syndrome | 26.61 | 11.71 | 8 | 35204 | 82 | 29539233 |
Alcohol poisoning | 26.60 | 11.71 | 25 | 35187 | 3064 | 29536251 |
Burnout syndrome | 26.58 | 11.71 | 9 | 35203 | 139 | 29539176 |
Accessory spleen | 26.28 | 11.71 | 9 | 35203 | 144 | 29539171 |
Drug monitoring procedure incorrectly performed | 26.04 | 11.71 | 10 | 35202 | 225 | 29539090 |
Areflexia | 25.09 | 11.71 | 23 | 35189 | 2731 | 29536584 |
Blood ethanol increased | 24.85 | 11.71 | 12 | 35200 | 479 | 29538836 |
Muscle rigidity | 24.71 | 11.71 | 42 | 35170 | 9369 | 29529946 |
Substance abuse | 24.40 | 11.71 | 35 | 35177 | 6752 | 29532563 |
Post concussion syndrome | 24.15 | 11.71 | 8 | 35204 | 115 | 29539200 |
Death | 24.14 | 11.71 | 276 | 34936 | 341808 | 29197507 |
Antiphospholipid antibodies positive | 24.01 | 11.71 | 10 | 35202 | 280 | 29539035 |
Psychomotor skills impaired | 23.81 | 11.71 | 22 | 35190 | 2639 | 29536676 |
Renal failure | 23.59 | 11.71 | 68 | 35144 | 118531 | 29420784 |
Arteriovenous fistula | 23.45 | 11.71 | 13 | 35199 | 693 | 29538622 |
Behaviour disorder | 23.29 | 11.71 | 25 | 35187 | 3591 | 29535724 |
Dysarthria | 22.99 | 11.71 | 85 | 35127 | 30826 | 29508489 |
Hypoglycaemia | 22.90 | 11.71 | 116 | 35096 | 48230 | 29491085 |
Restlessness | 22.82 | 11.71 | 68 | 35144 | 22077 | 29517238 |
Paraneoplastic rash | 22.60 | 11.71 | 7 | 35205 | 80 | 29539235 |
Coma scale abnormal | 22.37 | 11.71 | 24 | 35188 | 3445 | 29535870 |
Femoral artery aneurysm | 21.62 | 11.71 | 8 | 35204 | 162 | 29539153 |
Injection site pain | 21.47 | 11.71 | 6 | 35206 | 32440 | 29506875 |
Pemphigoid | 21.47 | 11.71 | 35 | 35177 | 7546 | 29531769 |
Coronary artery disease | 21.46 | 11.71 | 13 | 35199 | 44177 | 29495138 |
Eosinophil percentage increased | 21.43 | 11.71 | 11 | 35201 | 501 | 29538814 |
Respiratory failure | 21.35 | 11.71 | 53 | 35159 | 97078 | 29442237 |
Normochromic normocytic anaemia | 21.32 | 11.71 | 24 | 35188 | 3634 | 29535681 |
Opiates positive | 21.23 | 11.71 | 11 | 35201 | 511 | 29538804 |
Psychiatric decompensation | 20.83 | 11.71 | 16 | 35196 | 1488 | 29537827 |
Pneumonia | 20.78 | 11.71 | 263 | 34949 | 319909 | 29219406 |
Lymphocyte percentage decreased | 20.66 | 11.71 | 18 | 35194 | 1999 | 29537316 |
Neuropathy peripheral | 20.55 | 11.71 | 33 | 35179 | 70994 | 29468321 |
Neutrophil percentage increased | 20.51 | 11.71 | 17 | 35195 | 1764 | 29537551 |
Ischaemic stroke | 20.35 | 11.71 | 53 | 35159 | 15924 | 29523391 |
Device dislocation | 20.31 | 11.71 | 26 | 35186 | 4501 | 29534814 |
Diarrhoea | 20.24 | 11.71 | 277 | 34935 | 332421 | 29206894 |
Loss of consciousness | 20.11 | 11.71 | 154 | 35058 | 73902 | 29465413 |
Toxic epidermal necrolysis | 19.91 | 11.71 | 57 | 35155 | 18096 | 29521219 |
Spinal cord haemorrhage | 19.90 | 11.71 | 9 | 35203 | 309 | 29539006 |
Electrocardiogram abnormal | 19.65 | 11.71 | 33 | 35179 | 7289 | 29532026 |
Hemiplegia | 19.43 | 11.71 | 31 | 35181 | 6563 | 29532752 |
Sedation | 19.43 | 11.71 | 55 | 35157 | 17350 | 29521965 |
Expired product administered | 19.11 | 11.71 | 20 | 35192 | 2791 | 29536524 |
Urogenital haemorrhage | 19.00 | 11.71 | 10 | 35202 | 480 | 29538835 |
Tooth injury | 18.95 | 11.71 | 12 | 35200 | 818 | 29538497 |
Delirium febrile | 18.70 | 11.71 | 5 | 35207 | 32 | 29539283 |
Blepharospasm | 18.64 | 11.71 | 13 | 35199 | 1042 | 29538273 |
Blood pressure systolic increased | 18.58 | 11.71 | 53 | 35159 | 16792 | 29522523 |
Rash maculo-papular | 18.23 | 11.71 | 67 | 35145 | 24222 | 29515093 |
Intentional device misuse | 17.93 | 11.71 | 7 | 35205 | 165 | 29539150 |
Urine leukocyte esterase positive | 17.82 | 11.71 | 9 | 35203 | 396 | 29538919 |
Conjunctival hyperaemia | 17.78 | 11.71 | 17 | 35195 | 2128 | 29537187 |
Dermatitis psoriasiform | 17.75 | 11.71 | 13 | 35199 | 1125 | 29538190 |
Bradycardia | 17.55 | 11.71 | 136 | 35076 | 65493 | 29473822 |
Body temperature decreased | 17.47 | 11.71 | 39 | 35173 | 10625 | 29528690 |
Implant site infection | 17.07 | 11.71 | 12 | 35200 | 974 | 29538341 |
Depressed level of consciousness | 17.04 | 11.71 | 88 | 35124 | 36854 | 29502461 |
Band neutrophil percentage increased | 17.03 | 11.71 | 6 | 35206 | 105 | 29539210 |
Disorientation | 17.02 | 11.71 | 75 | 35137 | 29440 | 29509875 |
Pancreatitis | 16.97 | 11.71 | 10 | 35202 | 34504 | 29504811 |
Capillary fragility | 16.93 | 11.71 | 5 | 35207 | 48 | 29539267 |
Obsessive thoughts | 16.77 | 11.71 | 10 | 35202 | 612 | 29538703 |
Mean cell haemoglobin concentration increased | 16.76 | 11.71 | 8 | 35204 | 311 | 29539004 |
Clumsiness | 16.57 | 11.71 | 14 | 35198 | 1492 | 29537823 |
General symptom | 16.52 | 11.71 | 11 | 35201 | 817 | 29538498 |
Drug resistance | 16.22 | 11.71 | 3 | 35209 | 21537 | 29517778 |
Erythrosis | 16.15 | 11.71 | 5 | 35207 | 57 | 29539258 |
Behavioural addiction | 16.14 | 11.71 | 4 | 35208 | 18 | 29539297 |
Depression suicidal | 16.08 | 11.71 | 13 | 35199 | 1302 | 29538013 |
Blood creatinine increased | 16.05 | 11.71 | 50 | 35162 | 85052 | 29454263 |
Drug ineffective | 15.95 | 11.71 | 321 | 34891 | 362849 | 29176466 |
Intra-abdominal fluid collection | 15.75 | 11.71 | 12 | 35200 | 1103 | 29538212 |
Bacillus bacteraemia | 15.70 | 11.71 | 5 | 35207 | 63 | 29539252 |
Epilepsy | 15.69 | 11.71 | 53 | 35159 | 18379 | 29520936 |
Hospitalisation | 15.66 | 11.71 | 19 | 35193 | 45969 | 29493346 |
Malaise | 15.31 | 11.71 | 271 | 34941 | 159331 | 29379984 |
Hyperkalaemia | 15.20 | 11.71 | 125 | 35087 | 61267 | 29478048 |
Double inlet left ventricle | 15.18 | 11.71 | 4 | 35208 | 24 | 29539291 |
Feelings of worthlessness | 14.96 | 11.71 | 7 | 35205 | 260 | 29539055 |
Sensorimotor disorder | 14.88 | 11.71 | 8 | 35204 | 401 | 29538914 |
pH urine increased | 14.84 | 11.71 | 5 | 35207 | 76 | 29539239 |
Congenital hand malformation | 14.79 | 11.71 | 9 | 35203 | 572 | 29538743 |
Hypercapnia | 14.56 | 11.71 | 20 | 35192 | 3706 | 29535609 |
Deep vein thrombosis | 14.50 | 11.71 | 29 | 35183 | 57370 | 29481945 |
Immune-mediated hepatitis | 14.39 | 11.71 | 13 | 35199 | 1514 | 29537801 |
COVID-19 | 14.38 | 11.71 | 13 | 35199 | 36001 | 29503314 |
Phonophobia | 14.34 | 11.71 | 6 | 35206 | 170 | 29539145 |
Abdominal compartment syndrome | 14.04 | 11.71 | 10 | 35202 | 829 | 29538486 |
Reading disorder | 14.03 | 11.71 | 8 | 35204 | 450 | 29538865 |
Neutrophil count increased | 14.00 | 11.71 | 44 | 35168 | 14698 | 29524617 |
Spleen congestion | 13.99 | 11.71 | 7 | 35205 | 302 | 29539013 |
Gamma-glutamyltransferase increased | 13.97 | 11.71 | 66 | 35146 | 26671 | 29512644 |
Adrenocortical insufficiency acute | 13.97 | 11.71 | 12 | 35200 | 1308 | 29538007 |
Haemorrhage | 13.94 | 11.71 | 20 | 35192 | 45052 | 29494263 |
Therapy non-responder | 13.78 | 11.71 | 10 | 35202 | 30901 | 29508414 |
Univentricular heart | 13.77 | 11.71 | 4 | 35208 | 36 | 29539279 |
Speech disorder | 13.75 | 11.71 | 60 | 35152 | 23456 | 29515859 |
Hypertension | 13.71 | 11.71 | 82 | 35130 | 116532 | 29422783 |
Dyspnoea | 13.68 | 11.71 | 291 | 34921 | 326441 | 29212874 |
Tachycardia | 13.65 | 11.71 | 139 | 35073 | 72271 | 29467044 |
Antipsychotic drug level increased | 13.57 | 11.71 | 18 | 35194 | 3225 | 29536090 |
Periarthritis | 13.46 | 11.71 | 10 | 35202 | 885 | 29538430 |
Respiratory arrest | 13.40 | 11.71 | 7 | 35205 | 25826 | 29513489 |
Vascular purpura | 13.33 | 11.71 | 12 | 35200 | 1391 | 29537924 |
Pyrexia | 13.28 | 11.71 | 252 | 34960 | 287370 | 29251945 |
Microvascular coronary artery disease | 13.22 | 11.71 | 4 | 35208 | 42 | 29539273 |
Purpura | 13.19 | 11.71 | 32 | 35180 | 9200 | 29530115 |
Hypersensitivity | 13.13 | 11.71 | 27 | 35185 | 52876 | 29486439 |
Depressive symptom | 13.10 | 11.71 | 13 | 35199 | 1704 | 29537611 |
Choking | 13.08 | 11.71 | 21 | 35191 | 4470 | 29534845 |
Stoma site haemorrhage | 13.05 | 11.71 | 9 | 35203 | 708 | 29538607 |
Exhibitionism | 13.05 | 11.71 | 4 | 35208 | 44 | 29539271 |
Optic nerve cupping | 13.05 | 11.71 | 4 | 35208 | 44 | 29539271 |
Blood creatine phosphokinase increased | 13.04 | 11.71 | 88 | 35124 | 40556 | 29498759 |
Sinusitis | 13.01 | 11.71 | 13 | 35199 | 34337 | 29504978 |
Dizziness | 12.95 | 11.71 | 154 | 35058 | 189530 | 29349785 |
Onychomycosis | 12.83 | 11.71 | 14 | 35198 | 2048 | 29537267 |
Obsessive-compulsive disorder | 12.79 | 11.71 | 21 | 35191 | 4555 | 29534760 |
Disturbance in attention | 12.78 | 11.71 | 55 | 35157 | 21369 | 29517946 |
Hepatic steatosis | 12.74 | 11.71 | 43 | 35169 | 14903 | 29524412 |
Psychotic disorder | 12.72 | 11.71 | 53 | 35159 | 20301 | 29519014 |
Akathisia | 12.59 | 11.71 | 26 | 35186 | 6716 | 29532599 |
Acute respiratory failure | 12.50 | 11.71 | 8 | 35204 | 26394 | 29512921 |
Chronic kidney disease | 12.45 | 11.71 | 15 | 35197 | 36401 | 29502914 |
Cough | 12.45 | 11.71 | 94 | 35118 | 126633 | 29412682 |
Band neutrophil count increased | 12.44 | 11.71 | 6 | 35206 | 239 | 29539076 |
Asthenia | 12.41 | 11.71 | 181 | 35031 | 215069 | 29324246 |
Diabetic coma | 12.37 | 11.71 | 9 | 35203 | 771 | 29538544 |
Parkinsonism | 12.36 | 11.71 | 27 | 35185 | 7251 | 29532064 |
Perineal pain | 12.35 | 11.71 | 9 | 35203 | 773 | 29538542 |
Blood glucose increased | 12.33 | 11.71 | 33 | 35179 | 58951 | 29480364 |
Cyanosis central | 12.24 | 11.71 | 5 | 35207 | 133 | 29539182 |
Noninfective gingivitis | 12.10 | 11.71 | 6 | 35206 | 254 | 29539061 |
Bone marrow failure | 12.08 | 11.71 | 9 | 35203 | 27440 | 29511875 |
Hepatic cytolysis | 12 | 11.71 | 29 | 35183 | 8318 | 29530997 |
Hyponatraemic seizure | 11.98 | 11.71 | 4 | 35208 | 59 | 29539256 |
Acute kidney injury | 11.91 | 11.71 | 406 | 34806 | 264861 | 29274454 |
Incorrect dose administered | 11.91 | 11.71 | 13 | 35199 | 32971 | 29506344 |
Asocial behaviour | 11.86 | 11.71 | 4 | 35208 | 61 | 29539254 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Coma | 840.78 | 10.69 | 864 | 103654 | 86751 | 64307463 |
Poisoning deliberate | 524.43 | 10.69 | 306 | 104212 | 13152 | 64381062 |
Intentional overdose | 514.45 | 10.69 | 680 | 103838 | 89264 | 64304950 |
Somnolence | 381.05 | 10.69 | 945 | 103573 | 202700 | 64191514 |
Intentional self-injury | 333.14 | 10.69 | 316 | 104202 | 28728 | 64365486 |
Lower respiratory tract infection | 287.63 | 10.69 | 535 | 103983 | 94079 | 64300135 |
Pneumonia aspiration | 232.20 | 10.69 | 375 | 104143 | 58896 | 64335318 |
Depression | 231.65 | 10.69 | 738 | 103780 | 182553 | 64211661 |
Muscle spasticity | 227.57 | 10.69 | 200 | 104318 | 16469 | 64377745 |
Ear pain | 197.03 | 10.69 | 223 | 104295 | 24913 | 64369301 |
Suicide attempt | 194.19 | 10.69 | 384 | 104134 | 70623 | 64323591 |
Toxicity to various agents | 169.82 | 10.69 | 1088 | 103430 | 362425 | 64031789 |
Body temperature increased | 165.95 | 10.69 | 248 | 104270 | 36418 | 64357796 |
Product dose omission issue | 149.77 | 10.69 | 64 | 104454 | 194683 | 64199531 |
Confusional state | 139.79 | 10.69 | 810 | 103708 | 260334 | 64133880 |
Respiratory disorder | 135.33 | 10.69 | 224 | 104294 | 35887 | 64358327 |
Miosis | 132.77 | 10.69 | 134 | 104384 | 13132 | 64381082 |
Cardiac failure congestive | 131.25 | 10.69 | 26 | 104492 | 130554 | 64263660 |
Hepatocellular injury | 121.67 | 10.69 | 243 | 104275 | 44992 | 64349222 |
Night sweats | 117.24 | 10.69 | 210 | 104308 | 35836 | 64358378 |
Drug interaction | 117.00 | 10.69 | 993 | 103525 | 361090 | 64033124 |
Electric shock | 110.66 | 10.69 | 48 | 104470 | 1081 | 64393133 |
Electrocardiogram QT prolonged | 107.68 | 10.69 | 328 | 104190 | 79120 | 64315094 |
Muscle injury | 107.23 | 10.69 | 170 | 104348 | 26267 | 64367947 |
Hypothermia | 101.05 | 10.69 | 142 | 104376 | 19714 | 64374500 |
Folliculitis | 97.52 | 10.69 | 175 | 104343 | 29902 | 64364312 |
Drug dependence | 96.93 | 10.69 | 185 | 104333 | 33127 | 64361087 |
Akathisia | 96.86 | 10.69 | 106 | 104412 | 11404 | 64382810 |
Sinusitis | 96.58 | 10.69 | 480 | 104038 | 145448 | 64248766 |
Death | 83.95 | 10.69 | 450 | 104068 | 482255 | 63911959 |
Ill-defined disorder | 83.79 | 10.69 | 206 | 104312 | 43846 | 64350368 |
Mental status changes | 82.31 | 10.69 | 4 | 104514 | 61158 | 64333056 |
Irritable bowel syndrome | 82.24 | 10.69 | 185 | 104333 | 37184 | 64357030 |
Suicidal ideation | 81.23 | 10.69 | 265 | 104253 | 66277 | 64327937 |
Myocardial infarction | 80.42 | 10.69 | 90 | 104428 | 165731 | 64228483 |
Insomnia | 77.76 | 10.69 | 568 | 103950 | 197268 | 64196946 |
Antipsychotic drug level increased | 77.17 | 10.69 | 65 | 104453 | 5050 | 64389164 |
Sleep disorder due to general medical condition, insomnia type | 76.56 | 10.69 | 146 | 104372 | 26124 | 64368090 |
Post-traumatic stress disorder | 70.90 | 10.69 | 57 | 104461 | 4148 | 64390066 |
Overdose | 70.24 | 10.69 | 471 | 104047 | 159095 | 64235119 |
Respiratory failure | 65.31 | 10.69 | 100 | 104418 | 161083 | 64233131 |
Asphyxia | 65.17 | 10.69 | 79 | 104439 | 9487 | 64384727 |
Neovascularisation | 65.01 | 10.69 | 33 | 104485 | 1070 | 64393144 |
Somnambulism | 64.84 | 10.69 | 59 | 104459 | 5082 | 64389132 |
Housebound | 63.30 | 10.69 | 25 | 104493 | 440 | 64393774 |
Altered state of consciousness | 61.52 | 10.69 | 167 | 104351 | 37735 | 64356479 |
Cholestasis | 61.47 | 10.69 | 186 | 104332 | 44686 | 64349528 |
Drug ineffective | 60.68 | 10.69 | 978 | 103540 | 839269 | 63554945 |
Intervertebral discitis | 60.23 | 10.69 | 50 | 104468 | 3807 | 64390407 |
Depressed level of consciousness | 59.72 | 10.69 | 276 | 104242 | 81160 | 64313054 |
Neuroleptic malignant syndrome | 58.67 | 10.69 | 127 | 104391 | 24869 | 64369345 |
Blood mercury abnormal | 58.04 | 10.69 | 19 | 104499 | 188 | 64394026 |
Injection site pain | 56.75 | 10.69 | 58 | 104460 | 111350 | 64282864 |
5-hydroxyindolacetic acid in urine increased | 55.75 | 10.69 | 19 | 104499 | 215 | 64393999 |
Disease progression | 55.40 | 10.69 | 90 | 104428 | 141590 | 64252624 |
Urticaria | 55.03 | 10.69 | 418 | 104100 | 146899 | 64247315 |
Drug hypersensitivity | 55.02 | 10.69 | 199 | 104319 | 237616 | 64156598 |
Sepsis | 54.45 | 10.69 | 191 | 104327 | 230150 | 64164064 |
Lupus vasculitis | 51.79 | 10.69 | 22 | 104496 | 470 | 64393744 |
Duodenal ulcer perforation | 51.70 | 10.69 | 148 | 104370 | 34477 | 64359737 |
Helicobacter infection | 50.66 | 10.69 | 157 | 104361 | 38205 | 64356009 |
Prescription form tampering | 50.54 | 10.69 | 20 | 104498 | 354 | 64393860 |
Behaviour disorder | 50.10 | 10.69 | 48 | 104470 | 4414 | 64389800 |
Pneumonia | 48.82 | 10.69 | 627 | 103891 | 558949 | 63835265 |
Low density lipoprotein decreased | 48.40 | 10.69 | 27 | 104491 | 1063 | 64393151 |
Depressed mood | 47.08 | 10.69 | 160 | 104358 | 40852 | 64353362 |
Urine leukocyte esterase positive | 46.78 | 10.69 | 41 | 104477 | 3362 | 64390852 |
Coronary artery disease | 46.19 | 10.69 | 20 | 104498 | 60413 | 64333801 |
Peripheral swelling | 46.06 | 10.69 | 530 | 103988 | 208623 | 64185591 |
Fluid retention | 45.12 | 10.69 | 20 | 104498 | 59586 | 64334628 |
Drug resistance | 45.07 | 10.69 | 3 | 104515 | 35099 | 64359115 |
Skin candida | 44.35 | 10.69 | 30 | 104488 | 1673 | 64392541 |
Impaired healing | 43.62 | 10.69 | 204 | 104314 | 60269 | 64333945 |
Dystonic tremor | 43.07 | 10.69 | 15 | 104503 | 182 | 64394032 |
Broncholithiasis | 42.72 | 10.69 | 14 | 104504 | 139 | 64394075 |
Renal failure | 42.69 | 10.69 | 151 | 104367 | 181537 | 64212677 |
Blister | 41.80 | 10.69 | 249 | 104269 | 80718 | 64313496 |
Gastrointestinal disorder | 40.16 | 10.69 | 266 | 104252 | 89443 | 64304771 |
Monocyte percentage increased | 40.00 | 10.69 | 30 | 104488 | 1970 | 64392244 |
Burnout syndrome | 39.98 | 10.69 | 16 | 104502 | 292 | 64393922 |
Contusion | 39.58 | 10.69 | 318 | 104200 | 113647 | 64280567 |
Nasopharyngitis | 39.28 | 10.69 | 488 | 104030 | 195585 | 64198629 |
White blood cells urine positive | 39.11 | 10.69 | 46 | 104472 | 5352 | 64388862 |
Temperature intolerance | 39.01 | 10.69 | 57 | 104461 | 8198 | 64386016 |
Blood creatinine increased | 38.16 | 10.69 | 104 | 104414 | 135678 | 64258536 |
Gastrooesophageal reflux disease | 38.11 | 10.69 | 248 | 104270 | 82895 | 64311319 |
Demyelination | 37.97 | 10.69 | 51 | 104467 | 6783 | 64387431 |
COVID-19 | 37.84 | 10.69 | 30 | 104488 | 65110 | 64329104 |
Wrong technique in product usage process | 37.65 | 10.69 | 30 | 104488 | 64944 | 64329270 |
Calcium deficiency | 37.53 | 10.69 | 20 | 104498 | 718 | 64393496 |
Bladder dilatation | 37.51 | 10.69 | 28 | 104490 | 1826 | 64392388 |
Pruritus | 36.94 | 10.69 | 711 | 103807 | 311689 | 64082525 |
Disturbance in attention | 36.86 | 10.69 | 148 | 104370 | 40926 | 64353288 |
Hyponatraemia | 36.35 | 10.69 | 384 | 104134 | 147955 | 64246259 |
Completed suicide | 36.29 | 10.69 | 214 | 104304 | 224200 | 64170014 |
General physical health deterioration | 36.02 | 10.69 | 497 | 104021 | 203928 | 64190286 |
Balance disorder | 35.86 | 10.69 | 246 | 104272 | 83680 | 64310534 |
Cerebral artery thrombosis | 35.84 | 10.69 | 22 | 104496 | 1037 | 64393177 |
Neutrophil percentage increased | 35.78 | 10.69 | 40 | 104478 | 4405 | 64389809 |
Thrombosis | 34.60 | 10.69 | 38 | 104480 | 70604 | 64323610 |
Lymphocyte percentage decreased | 34.32 | 10.69 | 40 | 104478 | 4609 | 64389605 |
Postmortem blood drug level abnormal | 34.23 | 10.69 | 18 | 104500 | 629 | 64393585 |
Cardiac arrest | 33.60 | 10.69 | 132 | 104386 | 153932 | 64240282 |
Extrapyramidal disorder | 33.60 | 10.69 | 88 | 104430 | 19464 | 64374750 |
Rheumatoid arthritis | 32.93 | 10.69 | 409 | 104109 | 163885 | 64230329 |
Lymph node calcification | 32.70 | 10.69 | 14 | 104504 | 305 | 64393909 |
Hallucination | 32.68 | 10.69 | 216 | 104302 | 72572 | 64321642 |
Injection site erythema | 32.61 | 10.69 | 40 | 104478 | 70760 | 64323454 |
Post-traumatic neck syndrome | 32.53 | 10.69 | 26 | 104492 | 1876 | 64392338 |
Deep vein thrombosis | 32.30 | 10.69 | 77 | 104441 | 105105 | 64289109 |
Renal impairment | 31.85 | 10.69 | 112 | 104406 | 134905 | 64259309 |
Injection site reaction | 31.80 | 10.69 | 18 | 104500 | 46646 | 64347568 |
Gastrointestinal haemorrhage | 31.72 | 10.69 | 109 | 104409 | 132203 | 64262011 |
Mydriasis | 31.69 | 10.69 | 74 | 104444 | 15238 | 64378976 |
Brain scan abnormal | 31.43 | 10.69 | 21 | 104497 | 1147 | 64393067 |
Macrophages increased | 31.38 | 10.69 | 12 | 104506 | 193 | 64394021 |
C-reactive protein abnormal | 30.87 | 10.69 | 5 | 104513 | 29042 | 64365172 |
Bronchial wall thickening | 30.36 | 10.69 | 25 | 104493 | 1882 | 64392332 |
Hypervolaemia | 30.34 | 10.69 | 12 | 104506 | 38273 | 64355941 |
Product quality issue | 29.78 | 10.69 | 6 | 104512 | 29793 | 64364421 |
Chronic kidney disease | 29.66 | 10.69 | 30 | 104488 | 57889 | 64336325 |
Band neutrophil percentage increased | 29.60 | 10.69 | 14 | 104504 | 388 | 64393826 |
Joint swelling | 29.60 | 10.69 | 502 | 104016 | 214880 | 64179334 |
Sputum discoloured | 29.29 | 10.69 | 79 | 104439 | 17777 | 64376437 |
Blood glucose increased | 29.17 | 10.69 | 73 | 104445 | 98000 | 64296214 |
Alcohol poisoning | 28.76 | 10.69 | 35 | 104483 | 4220 | 64389994 |
Atrial fibrillation | 28.27 | 10.69 | 162 | 104356 | 170927 | 64223287 |
Hospitalisation | 28.25 | 10.69 | 49 | 104469 | 75158 | 64319056 |
Obstructive airways disorder | 27.98 | 10.69 | 92 | 104426 | 23093 | 64371121 |
Soft tissue injury | 27.89 | 10.69 | 22 | 104496 | 1557 | 64392657 |
Injection site bruising | 27.85 | 10.69 | 12 | 104506 | 36361 | 64357853 |
Toxic skin eruption | 27.41 | 10.69 | 81 | 104437 | 19203 | 64375011 |
Cytomegalovirus infection | 27.35 | 10.69 | 13 | 104505 | 37186 | 64357028 |
Agitation | 27.18 | 10.69 | 240 | 104278 | 88127 | 64306087 |
Pemphigoid | 27.13 | 10.69 | 63 | 104455 | 12923 | 64381291 |
Fall | 27.13 | 10.69 | 875 | 103643 | 415951 | 63978263 |
Neutrophil count increased | 26.97 | 10.69 | 96 | 104422 | 25078 | 64369136 |
Agranulocytosis | 26.86 | 10.69 | 128 | 104390 | 38101 | 64356113 |
Sleep disorder | 26.69 | 10.69 | 177 | 104341 | 59532 | 64334682 |
Urine abnormality | 26.68 | 10.69 | 45 | 104473 | 7317 | 64386897 |
Diaphragmatic rupture | 26.56 | 10.69 | 11 | 104507 | 220 | 64393994 |
Bradypnoea | 26.40 | 10.69 | 37 | 104481 | 5122 | 64389092 |
Puncture site haematoma | 26.14 | 10.69 | 10 | 104508 | 161 | 64394053 |
Blood urea increased | 26.07 | 10.69 | 20 | 104498 | 44133 | 64350081 |
Nightmare | 25.96 | 10.69 | 84 | 104434 | 20909 | 64373305 |
Gallbladder adenocarcinoma | 25.93 | 10.69 | 9 | 104509 | 108 | 64394106 |
Vocal cord dysfunction | 25.88 | 10.69 | 13 | 104505 | 412 | 64393802 |
Red blood cells urine | 25.75 | 10.69 | 15 | 104503 | 642 | 64393572 |
Libido increased | 25.48 | 10.69 | 22 | 104496 | 1768 | 64392446 |
Excessive eye blinking | 25.43 | 10.69 | 19 | 104499 | 1241 | 64392973 |
Oedema | 25.39 | 10.69 | 71 | 104447 | 91864 | 64302350 |
Injection site swelling | 25.36 | 10.69 | 18 | 104500 | 41335 | 64352879 |
Choking | 25.25 | 10.69 | 54 | 104464 | 10484 | 64383730 |
Lupus nephritis | 25.20 | 10.69 | 25 | 104493 | 2399 | 64391815 |
Pulmonary hypertension | 24.89 | 10.69 | 20 | 104498 | 43119 | 64351095 |
Blood pressure systolic increased | 24.83 | 10.69 | 151 | 104367 | 49302 | 64344912 |
Neurotoxicity | 24.48 | 10.69 | 7 | 104511 | 27397 | 64366817 |
Obsessive-compulsive disorder | 23.83 | 10.69 | 34 | 104484 | 4784 | 64389430 |
Blood calcium decreased | 23.83 | 10.69 | 6 | 104512 | 25548 | 64368666 |
Injection site pruritus | 23.82 | 10.69 | 16 | 104502 | 37810 | 64356404 |
Postmortem blood drug level increased | 23.71 | 10.69 | 15 | 104503 | 746 | 64393468 |
Coagulopathy | 23.71 | 10.69 | 11 | 104507 | 31909 | 64362305 |
Hostility | 23.39 | 10.69 | 23 | 104495 | 2184 | 64392030 |
Band neutrophil count increased | 23.18 | 10.69 | 14 | 104504 | 641 | 64393573 |
Loss of personal independence in daily activities | 22.92 | 10.69 | 198 | 104320 | 72256 | 64321958 |
Hyperthermia | 22.76 | 10.69 | 66 | 104452 | 15484 | 64378730 |
Carcinoid tumour pulmonary | 22.70 | 10.69 | 11 | 104507 | 322 | 64393892 |
Specific gravity urine increased | 22.44 | 10.69 | 12 | 104506 | 434 | 64393780 |
Respiratory arrest | 22.29 | 10.69 | 32 | 104486 | 52953 | 64341261 |
Acute respiratory failure | 22.17 | 10.69 | 29 | 104489 | 49905 | 64344309 |
Pericarditis | 22.00 | 10.69 | 175 | 104343 | 62341 | 64331873 |
Accessory spleen | 21.92 | 10.69 | 9 | 104509 | 176 | 64394038 |
Concussion | 21.76 | 10.69 | 43 | 104475 | 7895 | 64386319 |
Implant site extravasation | 21.50 | 10.69 | 14 | 104504 | 732 | 64393482 |
Toxicologic test abnormal | 21.50 | 10.69 | 17 | 104501 | 1208 | 64393006 |
Therapy cessation | 21.47 | 10.69 | 13 | 104505 | 32476 | 64361738 |
Haemorrhage | 21.38 | 10.69 | 62 | 104456 | 79289 | 64314925 |
Infusion related reaction | 21.38 | 10.69 | 380 | 104138 | 164087 | 64230127 |
Scratch | 21.34 | 10.69 | 38 | 104480 | 6451 | 64387763 |
Cellulitis | 21.21 | 10.69 | 79 | 104439 | 93578 | 64300636 |
Coma scale abnormal | 21.18 | 10.69 | 42 | 104476 | 7732 | 64386482 |
Serum ferritin abnormal | 21.00 | 10.69 | 11 | 104507 | 381 | 64393833 |
Distal intestinal obstruction syndrome | 20.95 | 10.69 | 13 | 104505 | 625 | 64393589 |
White blood cell count decreased | 20.76 | 10.69 | 160 | 104358 | 157677 | 64236537 |
Platelet count decreased | 20.68 | 10.69 | 173 | 104345 | 167538 | 64226676 |
Lactic acidosis | 20.57 | 10.69 | 170 | 104348 | 61240 | 64332974 |
Paraneoplastic rash | 20.48 | 10.69 | 7 | 104511 | 80 | 64394134 |
Tachycardia | 20.30 | 10.69 | 348 | 104170 | 149231 | 64244983 |
Liver function test abnormal | 20.28 | 10.69 | 41 | 104477 | 59360 | 64334854 |
Hypertension | 20.19 | 10.69 | 297 | 104221 | 258964 | 64135250 |
Multiple organ dysfunction syndrome | 20.17 | 10.69 | 90 | 104428 | 101323 | 64292891 |
Ascites | 20.16 | 10.69 | 44 | 104474 | 61957 | 64332257 |
Multiple sclerosis | 20.09 | 10.69 | 72 | 104446 | 18869 | 64375345 |
Antidepressant drug level above therapeutic | 20.05 | 10.69 | 12 | 104506 | 540 | 64393674 |
Bilirubin urine present | 19.82 | 10.69 | 10 | 104508 | 320 | 64393894 |
Inappropriate antidiuretic hormone secretion | 19.75 | 10.69 | 80 | 104438 | 22209 | 64372005 |
Pain in extremity | 19.71 | 10.69 | 359 | 104159 | 302726 | 64091488 |
Myelosuppression | 19.67 | 10.69 | 7 | 104511 | 23823 | 64370391 |
Sternal fracture | 19.44 | 10.69 | 21 | 104497 | 2226 | 64391988 |
Sopor | 19.42 | 10.69 | 12 | 104506 | 29649 | 64364565 |
Substance abuse | 19.33 | 10.69 | 45 | 104473 | 9247 | 64384967 |
Myelocyte percentage increased | 19.28 | 10.69 | 9 | 104509 | 242 | 64393972 |
Erythrosis | 19.26 | 10.69 | 7 | 104511 | 97 | 64394117 |
Hallucination, synaesthetic | 19.24 | 10.69 | 6 | 104512 | 50 | 64394164 |
Malignant polyp | 19.23 | 10.69 | 8 | 104510 | 162 | 64394052 |
Poor quality sleep | 19.22 | 10.69 | 71 | 104447 | 18880 | 64375334 |
Angina pectoris | 19.19 | 10.69 | 27 | 104491 | 45054 | 64349160 |
Opiates positive | 19.15 | 10.69 | 14 | 104504 | 884 | 64393330 |
Unevaluable event | 18.86 | 10.69 | 33 | 104485 | 50456 | 64343758 |
Drug abuse | 18.70 | 10.69 | 310 | 104208 | 132064 | 64262150 |
Hepatic neoplasm | 18.70 | 10.69 | 24 | 104494 | 3053 | 64391161 |
Dysarthria | 18.61 | 10.69 | 162 | 104356 | 59244 | 64334970 |
Contraindicated product administered | 18.50 | 10.69 | 261 | 104257 | 107568 | 64286646 |
Posterior reversible encephalopathy syndrome | 18.50 | 10.69 | 7 | 104511 | 22939 | 64371275 |
Menopause | 18.47 | 10.69 | 18 | 104500 | 1690 | 64392524 |
Wrong rate | 18.36 | 10.69 | 6 | 104512 | 59 | 64394155 |
Procedural anxiety | 18.27 | 10.69 | 12 | 104506 | 637 | 64393577 |
Mania | 18.22 | 10.69 | 63 | 104455 | 16223 | 64377991 |
Femoral artery aneurysm | 18.21 | 10.69 | 8 | 104510 | 186 | 64394028 |
Laryngeal stenosis | 18.17 | 10.69 | 13 | 104505 | 794 | 64393420 |
Abortion spontaneous | 18.16 | 10.69 | 9 | 104509 | 25134 | 64369080 |
Anti-cyclic citrullinated peptide antibody positive | 18.13 | 10.69 | 140 | 104378 | 49422 | 64344792 |
Blood ethanol increased | 18.12 | 10.69 | 12 | 104506 | 646 | 64393568 |
Gait deviation | 18.09 | 10.69 | 6 | 104512 | 62 | 64394152 |
Drug monitoring procedure incorrectly performed | 17.96 | 10.69 | 10 | 104508 | 392 | 64393822 |
Psychiatric decompensation | 17.86 | 10.69 | 21 | 104497 | 2442 | 64391772 |
Ligament pain | 17.86 | 10.69 | 8 | 104510 | 195 | 64394019 |
Therapeutic response decreased | 17.83 | 10.69 | 36 | 104482 | 52152 | 64342062 |
Paradoxical drug reaction | 17.81 | 10.69 | 34 | 104484 | 6086 | 64388128 |
Hypersensitivity vasculitis | 17.79 | 10.69 | 36 | 104482 | 6725 | 64387489 |
Coordination abnormal | 17.72 | 10.69 | 59 | 104459 | 14905 | 64379309 |
Haemoglobin urine | 17.58 | 10.69 | 7 | 104511 | 126 | 64394088 |
Dyspnoea exertional | 17.49 | 10.69 | 61 | 104457 | 73669 | 64320545 |
Myocarditis septic | 17.45 | 10.69 | 5 | 104513 | 30 | 64394184 |
Psychomotor skills impaired | 17.38 | 10.69 | 26 | 104492 | 3819 | 64390395 |
Staphylococcal infection | 17.28 | 10.69 | 35 | 104483 | 50643 | 64343571 |
Exposure during pregnancy | 17.28 | 10.69 | 66 | 104452 | 77609 | 64316605 |
Drug level above therapeutic | 17.28 | 10.69 | 36 | 104482 | 6865 | 64387349 |
Product prescribing error | 17.27 | 10.69 | 107 | 104411 | 35162 | 64359052 |
Heart rate decreased | 17.16 | 10.69 | 150 | 104368 | 54917 | 64339297 |
Presyncope | 17.04 | 10.69 | 19 | 104499 | 35070 | 64359144 |
Abdominal pain upper | 16.94 | 10.69 | 387 | 104131 | 174643 | 64219571 |
Urine oxalate increased | 16.90 | 10.69 | 8 | 104510 | 222 | 64393992 |
Arteriovenous fistula | 16.82 | 10.69 | 13 | 104505 | 893 | 64393321 |
Malaise | 16.81 | 10.69 | 794 | 103724 | 395453 | 63998761 |
Accidental exposure to product | 16.80 | 10.69 | 11 | 104507 | 26353 | 64367861 |
Urine analysis abnormal | 16.78 | 10.69 | 32 | 104486 | 5724 | 64388490 |
Crystal urine present | 16.64 | 10.69 | 18 | 104500 | 1911 | 64392303 |
Mixed liver injury | 16.63 | 10.69 | 31 | 104487 | 5450 | 64388764 |
Ventricular extrasystoles | 16.57 | 10.69 | 4 | 104514 | 17525 | 64376689 |
Atelectasis | 16.55 | 10.69 | 12 | 104506 | 27254 | 64366960 |
Bone marrow failure | 16.45 | 10.69 | 33 | 104485 | 47919 | 64346295 |
Post procedural complication | 16.42 | 10.69 | 7 | 104511 | 21346 | 64372868 |
Bradycardia | 16.39 | 10.69 | 276 | 104242 | 117943 | 64276271 |
Logorrhoea | 16.32 | 10.69 | 26 | 104492 | 4033 | 64390181 |
Feelings of worthlessness | 16.20 | 10.69 | 10 | 104508 | 476 | 64393738 |
Rash maculo-papular | 16.19 | 10.69 | 131 | 104387 | 46895 | 64347319 |
Cerebral infarction | 16.10 | 10.69 | 26 | 104492 | 41018 | 64353196 |
Substance use disorder | 16.05 | 10.69 | 9 | 104509 | 358 | 64393856 |
Blood pressure diastolic abnormal | 15.94 | 10.69 | 49 | 104469 | 11868 | 64382346 |
Back pain | 15.94 | 10.69 | 524 | 103994 | 249647 | 64144567 |
Reading disorder | 15.83 | 10.69 | 12 | 104506 | 801 | 64393413 |
Infusion site scar | 15.83 | 10.69 | 8 | 104510 | 257 | 64393957 |
Rheumatoid factor positive | 15.81 | 10.69 | 20 | 104498 | 34918 | 64359296 |
Nystagmus | 15.77 | 10.69 | 41 | 104477 | 9027 | 64385187 |
Neutropenic sepsis | 15.69 | 10.69 | 77 | 104441 | 23195 | 64371019 |
Accommodation disorder | 15.65 | 10.69 | 10 | 104508 | 506 | 64393708 |
Osteomyelitis | 15.65 | 10.69 | 13 | 104505 | 27574 | 64366640 |
Incorrect route of product administration | 15.64 | 10.69 | 77 | 104441 | 23221 | 64370993 |
Poor venous access | 15.64 | 10.69 | 50 | 104468 | 12367 | 64381847 |
Plasma cell myeloma | 15.56 | 10.69 | 32 | 104486 | 46043 | 64348171 |
Parkinsonism | 15.56 | 10.69 | 55 | 104463 | 14318 | 64379896 |
No adverse event | 15.55 | 10.69 | 14 | 104504 | 28547 | 64365667 |
Product monitoring error | 15.50 | 10.69 | 30 | 104488 | 5424 | 64388790 |
Epilepsy | 15.34 | 10.69 | 100 | 104418 | 33431 | 64360783 |
Cardiac valve disease | 15.29 | 10.69 | 29 | 104489 | 5166 | 64389048 |
Cardio-respiratory arrest | 15.27 | 10.69 | 95 | 104423 | 98298 | 64295916 |
Peripheral circulatory failure | 15.25 | 10.69 | 11 | 104507 | 680 | 64393534 |
Weight increased | 15.20 | 10.69 | 453 | 104065 | 212895 | 64181319 |
Disseminated intravascular coagulation | 15.18 | 10.69 | 18 | 104500 | 32330 | 64361884 |
Red blood cell sedimentation rate increased | 15.07 | 10.69 | 17 | 104501 | 31218 | 64362996 |
Ataxia | 14.83 | 10.69 | 73 | 104445 | 22011 | 64372203 |
Restless legs syndrome | 14.82 | 10.69 | 61 | 104457 | 17055 | 64377159 |
Alanine aminotransferase increased | 14.72 | 10.69 | 149 | 104369 | 138882 | 64255332 |
Nephropathy toxic | 14.70 | 10.69 | 5 | 104513 | 17509 | 64376705 |
Respiratory depression | 14.70 | 10.69 | 76 | 104442 | 23367 | 64370847 |
Dry mouth | 14.60 | 10.69 | 156 | 104362 | 60262 | 64333952 |
Neutropenia | 14.59 | 10.69 | 287 | 104231 | 239337 | 64154877 |
Epistaxis | 14.59 | 10.69 | 96 | 104422 | 98035 | 64296179 |
Adverse event | 14.58 | 10.69 | 26 | 104492 | 39463 | 64354751 |
Eczema | 14.44 | 10.69 | 90 | 104428 | 29630 | 64364584 |
Red blood cells urine positive | 14.44 | 10.69 | 26 | 104492 | 4452 | 64389762 |
Urine ketone body present | 14.43 | 10.69 | 22 | 104496 | 3285 | 64390929 |
Amyotrophy | 14.42 | 10.69 | 10 | 104508 | 581 | 64393633 |
Anaemia | 14.38 | 10.69 | 486 | 104032 | 378194 | 64016020 |
Retinal depigmentation | 14.36 | 10.69 | 8 | 104510 | 314 | 64393900 |
Pancreatitis | 14.35 | 10.69 | 49 | 104469 | 59558 | 64334656 |
Analgesic drug level increased | 14.26 | 10.69 | 18 | 104500 | 2252 | 64391962 |
Progressive multifocal leukoencephalopathy | 14.26 | 10.69 | 63 | 104455 | 18169 | 64376045 |
Haematocrit increased | 14.24 | 10.69 | 22 | 104496 | 3323 | 64390891 |
Glucocorticoids increased | 14.22 | 10.69 | 6 | 104512 | 126 | 64394088 |
Polymicrogyria | 14.21 | 10.69 | 3 | 104515 | 3 | 64394211 |
Bronchiolitis | 14.19 | 10.69 | 23 | 104495 | 3618 | 64390596 |
Adrenal insufficiency | 14.17 | 10.69 | 73 | 104445 | 22414 | 64371800 |
Red cell distribution width increased | 14.10 | 10.69 | 48 | 104470 | 12261 | 64381953 |
Surgery | 14.01 | 10.69 | 15 | 104503 | 28198 | 64366016 |
Faecaloma | 13.96 | 10.69 | 41 | 104477 | 9687 | 64384527 |
Paternal exposure timing unspecified | 13.91 | 10.69 | 5 | 104513 | 67 | 64394147 |
Delirium febrile | 13.84 | 10.69 | 5 | 104513 | 68 | 64394146 |
Transient ischaemic attack | 13.83 | 10.69 | 32 | 104486 | 44150 | 64350064 |
Diabetes mellitus | 13.82 | 10.69 | 58 | 104460 | 66416 | 64327798 |
Acute myocardial infarction | 13.79 | 10.69 | 62 | 104456 | 69656 | 64324558 |
Mobility decreased | 13.78 | 10.69 | 82 | 104436 | 85758 | 64308456 |
Hypocoagulable state | 13.77 | 10.69 | 16 | 104502 | 1837 | 64392377 |
Occult blood | 13.73 | 10.69 | 14 | 104504 | 1388 | 64392826 |
Antipsychotic drug level above therapeutic | 13.72 | 10.69 | 16 | 104502 | 1845 | 64392369 |
Middle insomnia | 13.70 | 10.69 | 49 | 104469 | 12828 | 64381386 |
Haematuria | 13.70 | 10.69 | 51 | 104467 | 60420 | 64333794 |
Urine bilirubin decreased | 13.64 | 10.69 | 6 | 104512 | 140 | 64394074 |
Full blood count decreased | 13.62 | 10.69 | 10 | 104508 | 22572 | 64371642 |
Hypoglycaemia | 13.62 | 10.69 | 213 | 104305 | 89679 | 64304535 |
Failed induction of labour | 13.57 | 10.69 | 7 | 104511 | 235 | 64393979 |
Eosinophil percentage increased | 13.55 | 10.69 | 14 | 104504 | 1410 | 64392804 |
Bronchopulmonary aspergillosis | 13.53 | 10.69 | 7 | 104511 | 19078 | 64375136 |
Cerebrovascular accident | 13.53 | 10.69 | 150 | 104368 | 137433 | 64256781 |
Tri-iodothyronine free decreased | 13.51 | 10.69 | 8 | 104510 | 353 | 64393861 |
Metastases to lung | 13.45 | 10.69 | 4 | 104514 | 15260 | 64378954 |
Hepatotoxicity | 13.29 | 10.69 | 28 | 104490 | 39934 | 64354280 |
Cognitive disorder | 13.20 | 10.69 | 142 | 104376 | 54945 | 64339269 |
Blood creatine increased | 13.19 | 10.69 | 36 | 104482 | 8156 | 64386058 |
Stomatitis | 13.10 | 10.69 | 250 | 104268 | 109355 | 64284859 |
Psoriatic arthropathy | 13.03 | 10.69 | 32 | 104486 | 43249 | 64350965 |
Spinal cord haemorrhage | 12.93 | 10.69 | 9 | 104509 | 526 | 64393688 |
Glossodynia | 12.92 | 10.69 | 161 | 104357 | 64535 | 64329679 |
Transplant rejection | 12.92 | 10.69 | 6 | 104512 | 17395 | 64376819 |
Urinary sediment present | 12.92 | 10.69 | 17 | 104501 | 2217 | 64391997 |
Ileus | 12.81 | 10.69 | 11 | 104507 | 22955 | 64371259 |
Thirst decreased | 12.75 | 10.69 | 7 | 104511 | 267 | 64393947 |
Post concussion syndrome | 12.75 | 10.69 | 9 | 104509 | 538 | 64393676 |
Diabetic hyperosmolar coma | 12.70 | 10.69 | 10 | 104508 | 706 | 64393508 |
Incorrect dose administered | 12.65 | 10.69 | 53 | 104465 | 60712 | 64333502 |
Negative thoughts | 12.62 | 10.69 | 13 | 104505 | 1305 | 64392909 |
Withdrawal syndrome | 12.60 | 10.69 | 73 | 104445 | 23419 | 64370795 |
Vascular purpura | 12.59 | 10.69 | 18 | 104500 | 2538 | 64391676 |
Communication disorder | 12.57 | 10.69 | 22 | 104496 | 3684 | 64390530 |
Disorientation | 12.50 | 10.69 | 142 | 104376 | 55686 | 64338528 |
Device issue | 12.45 | 10.69 | 11 | 104507 | 22637 | 64371577 |
Aspartate aminotransferase increased | 12.42 | 10.69 | 129 | 104389 | 119659 | 64274555 |
Diabetic coma | 12.38 | 10.69 | 12 | 104506 | 1119 | 64393095 |
Personality disorder | 12.29 | 10.69 | 25 | 104493 | 4686 | 64389528 |
Tuberculosis | 12.27 | 10.69 | 3 | 104515 | 13035 | 64381179 |
Psychotic disorder | 12.27 | 10.69 | 97 | 104421 | 34481 | 64359733 |
Fungal infection | 12.25 | 10.69 | 23 | 104495 | 34228 | 64359986 |
Hepatic function abnormal | 12.24 | 10.69 | 58 | 104460 | 64255 | 64329959 |
Drug reaction with eosinophilia and systemic symptoms | 12.18 | 10.69 | 138 | 104380 | 54079 | 64340135 |
Victim of chemical submission | 12.16 | 10.69 | 7 | 104511 | 293 | 64393921 |
pH urine increased | 12.16 | 10.69 | 8 | 104510 | 426 | 64393788 |
Pemphigus | 12.10 | 10.69 | 151 | 104367 | 60550 | 64333664 |
Sinus rhythm | 12.10 | 10.69 | 9 | 104509 | 584 | 64393630 |
Bronchopulmonary aspergillosis allergic | 12.05 | 10.69 | 14 | 104504 | 1608 | 64392606 |
Angina unstable | 12.01 | 10.69 | 5 | 104513 | 15462 | 64378752 |
International normalised ratio increased | 11.99 | 10.69 | 77 | 104441 | 79090 | 64315124 |
Oral herpes | 11.99 | 10.69 | 69 | 104449 | 22083 | 64372131 |
Distributive shock | 11.99 | 10.69 | 15 | 104503 | 1860 | 64392354 |
Persecutory delusion | 11.98 | 10.69 | 23 | 104495 | 4135 | 64390079 |
Psychotic symptom | 11.95 | 10.69 | 16 | 104502 | 2122 | 64392092 |
Cutaneous lupus erythematosus | 11.93 | 10.69 | 18 | 104500 | 2664 | 64391550 |
Depressive symptom | 11.90 | 10.69 | 24 | 104494 | 4472 | 64389742 |
Social anxiety disorder | 11.89 | 10.69 | 8 | 104510 | 442 | 64393772 |
Serotonin syndrome | 11.86 | 10.69 | 29 | 104489 | 39253 | 64354961 |
Subdural haematoma | 11.84 | 10.69 | 82 | 104436 | 27972 | 64366242 |
Alcohol abuse | 11.78 | 10.69 | 25 | 104493 | 4827 | 64389387 |
Tumour marker abnormal | 11.75 | 10.69 | 6 | 104512 | 197 | 64394017 |
Pharyngeal paraesthesia | 11.73 | 10.69 | 15 | 104503 | 1902 | 64392312 |
Bacterial test | 11.73 | 10.69 | 12 | 104506 | 1195 | 64393019 |
Pancreatic carcinoma recurrent | 11.72 | 10.69 | 5 | 104513 | 108 | 64394106 |
Haemophagocytic lymphohistiocytosis | 11.70 | 10.69 | 7 | 104511 | 17602 | 64376612 |
Treatment noncompliance | 11.69 | 10.69 | 34 | 104484 | 43448 | 64350766 |
Lower gastrointestinal haemorrhage | 11.67 | 10.69 | 4 | 104514 | 13935 | 64380279 |
Body temperature decreased | 11.67 | 10.69 | 77 | 104441 | 25851 | 64368363 |
Oxygen saturation decreased | 11.65 | 10.69 | 241 | 104277 | 106935 | 64287279 |
Therapy non-responder | 11.64 | 10.69 | 61 | 104457 | 65838 | 64328376 |
Encephalitis | 11.63 | 10.69 | 3 | 104515 | 12568 | 64381646 |
Granulomatous liver disease | 11.60 | 10.69 | 12 | 104506 | 1210 | 64393004 |
Exhibitionism | 11.60 | 10.69 | 4 | 104514 | 47 | 64394167 |
Psychiatric symptom | 11.57 | 10.69 | 29 | 104489 | 6244 | 64387970 |
Bacillus bacteraemia | 11.55 | 10.69 | 5 | 104513 | 112 | 64394102 |
Epstein-Barr virus infection | 11.51 | 10.69 | 3 | 104515 | 12485 | 64381729 |
Phonophobia | 11.42 | 10.69 | 8 | 104510 | 472 | 64393742 |
Decreased appetite | 11.39 | 10.69 | 358 | 104160 | 280931 | 64113283 |
Tooth hypoplasia | 11.37 | 10.69 | 6 | 104512 | 211 | 64394003 |
Total lung capacity decreased | 11.37 | 10.69 | 14 | 104504 | 1708 | 64392506 |
Seizure | 11.37 | 10.69 | 196 | 104322 | 166696 | 64227518 |
Anhedonia | 11.36 | 10.69 | 4 | 104514 | 13702 | 64380512 |
Meningitis herpes | 11.32 | 10.69 | 6 | 104512 | 213 | 64394001 |
Optic nerve cupping | 11.24 | 10.69 | 4 | 104514 | 52 | 64394162 |
Cardiac failure | 11.23 | 10.69 | 149 | 104369 | 132224 | 64261990 |
Throat irritation | 11.19 | 10.69 | 91 | 104427 | 32620 | 64361594 |
Incoherent | 11.18 | 10.69 | 31 | 104487 | 7087 | 64387127 |
Right ventricular failure | 11.13 | 10.69 | 11 | 104507 | 21460 | 64372754 |
Drug screen positive | 11.11 | 10.69 | 27 | 104491 | 5702 | 64388512 |
Antiphospholipid antibodies positive | 11.06 | 10.69 | 9 | 104509 | 666 | 64393548 |
Injection site warmth | 11.03 | 10.69 | 4 | 104514 | 13458 | 64380756 |
Urogenital haemorrhage | 11.00 | 10.69 | 9 | 104509 | 671 | 64393543 |
Osteonecrosis | 10.96 | 10.69 | 18 | 104500 | 28211 | 64366003 |
Paranoia | 10.95 | 10.69 | 54 | 104464 | 16298 | 64377916 |
Toxic epidermal necrolysis | 10.94 | 10.69 | 100 | 104418 | 37066 | 64357148 |
Maternal exposure during pregnancy | 10.89 | 10.69 | 101 | 104417 | 95783 | 64298431 |
Chest wall mass | 10.87 | 10.69 | 5 | 104513 | 130 | 64394084 |
Oliguria | 10.86 | 10.69 | 5 | 104513 | 14571 | 64379643 |
Complement factor C4 decreased | 10.85 | 10.69 | 6 | 104512 | 232 | 64393982 |
Loss of consciousness | 10.83 | 10.69 | 316 | 104202 | 148049 | 64246165 |
Prothrombin time prolonged | 10.83 | 10.69 | 6 | 104512 | 15735 | 64378479 |
Chills | 10.76 | 10.69 | 157 | 104361 | 137107 | 64257107 |
Sensory level abnormal | 10.73 | 10.69 | 5 | 104513 | 134 | 64394080 |
Vasomotor rhinitis | 10.71 | 10.69 | 4 | 104514 | 60 | 64394154 |
Eye paraesthesia | 10.71 | 10.69 | 4 | 104514 | 60 | 64394154 |
Bone density decreased | 10.70 | 10.69 | 38 | 104480 | 9914 | 64384300 |
None
Source | Code | Description |
---|---|---|
ATC | N05CF01 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine related drugs |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D006993 | Hypnotics and Sedatives |
CHEBI has role | CHEBI:35488 | central nervous system depressants |
CHEBI has role | CHEBI:35717 | hypnotics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Insomnia | indication | 193462001 | |
Suicidal thoughts | contraindication | 6471006 | |
Asthenia | contraindication | 13791008 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Hepatic failure | contraindication | 59927004 | |
Sleep automatism | contraindication | 247962006 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.95 | Basic |
pKa2 | 2.26 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA A receptor alpha-5/beta-2/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 6.75 | WOMBAT-PK | DRUG LABEL | |||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 7.18 | WOMBAT-PK | DRUG LABEL | |||
GABA-A receptor alpha-5/beta-3/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 7.28 | WOMBAT-PK | DRUG LABEL | |||
GABA-A receptor alpha-1/beta-2/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 7.16 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 6.58 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-3/beta-2/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 6.49 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-5/beta-3/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 6.75 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-5/beta-2/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 7.28 | WOMBAT-PK | DRUG LABEL | |||
GABA-A receptor; anion channel | Ion channel | IC50 | 7.54 | CHEMBL |
ID | Source |
---|---|
D01372 | KEGG_DRUG |
C1436328 | UMLSCUI |
CHEBI:53762 | CHEBI |
ZPC | PDB_CHEM_ID |
CHEMBL135400 | ChEMBL_ID |
DB01198 | DRUGBANK_ID |
C515050 | MESH_SUPPLEMENTAL_RECORD_UI |
5735 | PUBCHEM_CID |
7430 | IUPHAR_LIGAND_ID |
4462 | INN_ID |
03A5ORL08Q | UNII |
152527 | RXNORM |
003775 | NDDF |
321174005 | SNOMEDCT_US |
395929002 | SNOMEDCT_US |
None