Stem definition | Drug id | CAS RN |
---|---|---|
hypnotic tranquillizers | 2873 | 43200-80-2 |
Dose | Unit | Route |
---|---|---|
7.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.12 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.28 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 15, 2004 | FDA | SUNOVION PHARMS INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 1379.15 | 39.68 | 387 | 1936 | 32367 | 2323395 |
Coma | 1077.40 | 39.68 | 247 | 2076 | 8809 | 2346953 |
Intentional overdose | 788.84 | 39.68 | 201 | 2122 | 11120 | 2344642 |
Somnolence | 733.72 | 39.68 | 222 | 2101 | 23263 | 2332499 |
Fall | 604.10 | 39.68 | 228 | 2095 | 46871 | 2308891 |
Pneumonia aspiration | 544.86 | 39.68 | 121 | 2202 | 3621 | 2352141 |
Suicide attempt | 534.67 | 39.68 | 148 | 2175 | 11134 | 2344628 |
Overdose | 447.66 | 39.68 | 147 | 2176 | 19760 | 2336002 |
Confusional state | 324.58 | 39.68 | 122 | 2201 | 24222 | 2331540 |
Hypotension | 277.19 | 39.68 | 118 | 2205 | 32318 | 2323444 |
Electrocardiogram QT prolonged | 276.96 | 39.68 | 82 | 2241 | 7732 | 2348030 |
Depressed level of consciousness | 257.27 | 39.68 | 77 | 2246 | 7527 | 2348235 |
Drug dependence | 249.86 | 39.68 | 62 | 2261 | 2983 | 2352779 |
Drug abuse | 238.21 | 39.68 | 81 | 2242 | 11945 | 2343817 |
Intentional self-injury | 217.03 | 39.68 | 59 | 2264 | 4068 | 2351694 |
Poisoning deliberate | 214.53 | 39.68 | 46 | 2277 | 1145 | 2354617 |
Gastrooesophageal reflux disease | 210.80 | 39.68 | 69 | 2254 | 9026 | 2346736 |
Orthostatic hypotension | 188.61 | 39.68 | 49 | 2274 | 2830 | 2352932 |
Completed suicide | 180.69 | 39.68 | 77 | 2246 | 20957 | 2334805 |
Altered state of consciousness | 174.37 | 39.68 | 49 | 2274 | 3811 | 2351951 |
Prescription form tampering | 152.47 | 39.68 | 25 | 2298 | 128 | 2355634 |
Loss of consciousness | 145.65 | 39.68 | 64 | 2259 | 18703 | 2337059 |
Tachycardia | 140.53 | 39.68 | 60 | 2263 | 16349 | 2339413 |
Hypokalaemia | 121.99 | 39.68 | 48 | 2275 | 10606 | 2345156 |
Mydriasis | 113.14 | 39.68 | 31 | 2292 | 2188 | 2353574 |
Hyponatraemia | 111.61 | 39.68 | 48 | 2275 | 13277 | 2342485 |
Hypersensitivity vasculitis | 99.09 | 39.68 | 25 | 2298 | 1277 | 2354485 |
Somnambulism | 97.95 | 39.68 | 23 | 2300 | 867 | 2354895 |
Hypotonia | 96.74 | 39.68 | 26 | 2297 | 1704 | 2354058 |
Malaise | 96.55 | 39.68 | 71 | 2252 | 55514 | 2300248 |
Hypothermia | 95.69 | 39.68 | 27 | 2296 | 2121 | 2353641 |
Acute kidney injury | 93.40 | 39.68 | 54 | 2269 | 28068 | 2327694 |
Agitation | 93.13 | 39.68 | 40 | 2283 | 11011 | 2344751 |
Hepatocellular injury | 90.67 | 39.68 | 30 | 2293 | 4025 | 2351737 |
Bradycardia | 90.31 | 39.68 | 38 | 2285 | 9943 | 2345819 |
Drug reaction with eosinophilia and systemic symptoms | 89.09 | 39.68 | 32 | 2291 | 5486 | 2350276 |
Rhabdomyolysis | 86.61 | 39.68 | 33 | 2290 | 6671 | 2349091 |
Asphyxia | 85.00 | 39.68 | 21 | 2302 | 983 | 2354779 |
Disturbance in attention | 84.44 | 39.68 | 31 | 2292 | 5654 | 2350108 |
Hallucination | 83.79 | 39.68 | 34 | 2289 | 8114 | 2347648 |
Foetal exposure during pregnancy | 83.07 | 39.68 | 30 | 2293 | 5222 | 2350540 |
Hallucination, visual | 82.78 | 39.68 | 26 | 2297 | 2953 | 2352809 |
Dysarthria | 81.33 | 39.68 | 31 | 2292 | 6271 | 2349491 |
Bezoar | 78.84 | 39.68 | 15 | 2308 | 198 | 2355564 |
Lung disorder | 78.16 | 39.68 | 30 | 2293 | 6182 | 2349580 |
Blood creatine phosphokinase increased | 76.24 | 39.68 | 28 | 2295 | 5108 | 2350654 |
Suicidal ideation | 73.71 | 39.68 | 34 | 2289 | 11053 | 2344709 |
Hypoglycaemia | 72.67 | 39.68 | 31 | 2292 | 8376 | 2347386 |
Sinus tachycardia | 71.92 | 39.68 | 24 | 2299 | 3301 | 2352461 |
Balance disorder | 71.45 | 39.68 | 32 | 2291 | 9715 | 2346047 |
Abdominal pain | 71.29 | 39.68 | 49 | 2274 | 34325 | 2321437 |
Miosis | 71.28 | 39.68 | 19 | 2304 | 1205 | 2354557 |
Exposure during pregnancy | 69.55 | 39.68 | 43 | 2280 | 25176 | 2330586 |
Cholestasis | 69.27 | 39.68 | 24 | 2299 | 3697 | 2352065 |
Anxiety | 68.41 | 39.68 | 45 | 2278 | 29314 | 2326448 |
Dehydration | 66.56 | 39.68 | 40 | 2283 | 22255 | 2333507 |
Intentional product misuse | 65.89 | 39.68 | 30 | 2293 | 9459 | 2346303 |
Circulatory collapse | 65.43 | 39.68 | 23 | 2300 | 3697 | 2352065 |
Shock | 63.78 | 39.68 | 23 | 2300 | 3981 | 2351781 |
Bradypnoea | 62.68 | 39.68 | 14 | 2309 | 420 | 2355342 |
Lethargy | 61.87 | 39.68 | 28 | 2295 | 8702 | 2347060 |
Agitation neonatal | 61.76 | 39.68 | 11 | 2312 | 98 | 2355664 |
Eczema | 60.93 | 39.68 | 21 | 2302 | 3184 | 2352578 |
Panic attack | 60.30 | 39.68 | 22 | 2301 | 3934 | 2351828 |
Extrapyramidal disorder | 59.06 | 39.68 | 19 | 2304 | 2328 | 2353434 |
Tremor | 58.90 | 39.68 | 36 | 2287 | 20625 | 2335137 |
Maternal exposure during pregnancy | 58.64 | 39.68 | 32 | 2291 | 14831 | 2340931 |
Interstitial lung disease | 58.36 | 39.68 | 26 | 2297 | 7786 | 2347976 |
Hyperhidrosis | 57.53 | 39.68 | 32 | 2291 | 15390 | 2340372 |
Disorientation | 56.72 | 39.68 | 24 | 2299 | 6348 | 2349414 |
Antipsychotic drug level above therapeutic | 55.83 | 39.68 | 11 | 2312 | 176 | 2355586 |
Agranulocytosis | 55.44 | 39.68 | 20 | 2303 | 3462 | 2352300 |
Foetal death | 54.40 | 39.68 | 17 | 2306 | 1895 | 2353867 |
Delirium | 54.36 | 39.68 | 22 | 2301 | 5201 | 2350561 |
Aggression | 52.72 | 39.68 | 21 | 2302 | 4765 | 2350997 |
Nausea | 52.62 | 39.68 | 70 | 2253 | 112119 | 2243643 |
Hallucination, auditory | 52.12 | 39.68 | 17 | 2306 | 2175 | 2353587 |
Diarrhoea | 51.77 | 39.68 | 60 | 2263 | 83504 | 2272258 |
Rash maculo-papular | 51.55 | 39.68 | 20 | 2303 | 4232 | 2351530 |
Cardio-respiratory arrest | 51.41 | 39.68 | 25 | 2298 | 9121 | 2346641 |
Analgesic drug level increased | 50.94 | 39.68 | 11 | 2312 | 281 | 2355481 |
Urinary retention | 50.76 | 39.68 | 19 | 2304 | 3648 | 2352114 |
Distributive shock | 50.05 | 39.68 | 9 | 2314 | 85 | 2355677 |
Developmental hip dysplasia | 49.70 | 39.68 | 10 | 2313 | 179 | 2355583 |
Urinary tract infection | 49.00 | 39.68 | 37 | 2286 | 29905 | 2325857 |
Sputum discoloured | 48.95 | 39.68 | 14 | 2309 | 1152 | 2354610 |
Cardiac arrest | 47.68 | 39.68 | 28 | 2295 | 14902 | 2340860 |
Depression | 46.55 | 39.68 | 35 | 2288 | 28097 | 2327665 |
Blood pressure decreased | 45.26 | 39.68 | 23 | 2300 | 9213 | 2346549 |
Inappropriate antidiuretic hormone secretion | 43.37 | 39.68 | 15 | 2308 | 2294 | 2353468 |
Ear haemorrhage | 42.79 | 39.68 | 9 | 2314 | 202 | 2355560 |
Diabetic hyperosmolar coma | 42.37 | 39.68 | 8 | 2315 | 101 | 2355661 |
Sedation | 41.41 | 39.68 | 16 | 2307 | 3346 | 2352416 |
Muscle twitching | 40.73 | 39.68 | 15 | 2308 | 2750 | 2353012 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 744.02 | 48.58 | 245 | 1440 | 28896 | 1716200 |
Coma | 634.06 | 48.58 | 160 | 1525 | 7102 | 1737994 |
Somnolence | 444.16 | 48.58 | 146 | 1539 | 16593 | 1728503 |
Confusional state | 413.64 | 48.58 | 147 | 1538 | 21131 | 1723965 |
Intentional overdose | 410.24 | 48.58 | 115 | 1570 | 7555 | 1737541 |
Overdose | 337.45 | 48.58 | 119 | 1566 | 16582 | 1728514 |
Poisoning deliberate | 336.86 | 48.58 | 65 | 1620 | 777 | 1744319 |
Fall | 325.37 | 48.58 | 132 | 1553 | 27082 | 1718014 |
Drug dependence | 252.77 | 48.58 | 66 | 1619 | 3261 | 1741835 |
Suicide attempt | 250.43 | 48.58 | 78 | 1607 | 7303 | 1737793 |
Drug abuse | 178.36 | 48.58 | 71 | 1614 | 13618 | 1731478 |
Prescription form tampering | 168.03 | 48.58 | 28 | 1657 | 130 | 1744966 |
Hypotension | 156.83 | 48.58 | 82 | 1603 | 29572 | 1715524 |
Hepatocellular injury | 147.40 | 48.58 | 43 | 1642 | 3188 | 1741908 |
Completed suicide | 143.41 | 48.58 | 64 | 1621 | 16248 | 1728848 |
Acute kidney injury | 136.11 | 48.58 | 79 | 1606 | 34865 | 1710231 |
Agitation | 122.18 | 48.58 | 51 | 1634 | 10975 | 1734121 |
Cholestasis | 120.84 | 48.58 | 38 | 1647 | 3627 | 1741469 |
Bradycardia | 117.63 | 48.58 | 49 | 1636 | 10485 | 1734611 |
Rhabdomyolysis | 111.87 | 48.58 | 48 | 1637 | 11042 | 1734054 |
Pneumonia aspiration | 111.15 | 48.58 | 39 | 1646 | 5227 | 1739869 |
Electrocardiogram QT prolonged | 109.18 | 48.58 | 39 | 1646 | 5506 | 1739590 |
Drug interaction | 100.17 | 48.58 | 60 | 1625 | 27898 | 1717198 |
Tachycardia | 99.57 | 48.58 | 46 | 1639 | 12582 | 1732514 |
Metabolic acidosis | 98.86 | 48.58 | 36 | 1649 | 5366 | 1739730 |
Intentional product misuse | 98.44 | 48.58 | 39 | 1646 | 7319 | 1737777 |
Alcohol poisoning | 95.31 | 48.58 | 21 | 1664 | 491 | 1744605 |
Hypothermia | 91.85 | 48.58 | 26 | 1659 | 1722 | 1743374 |
Hyperkalaemia | 89.44 | 48.58 | 38 | 1647 | 8509 | 1736587 |
Hypoglycaemia | 83.29 | 48.58 | 36 | 1649 | 8402 | 1736694 |
Insomnia | 82.76 | 48.58 | 44 | 1641 | 16232 | 1728864 |
Miosis | 82.26 | 48.58 | 23 | 1662 | 1455 | 1743641 |
Depression | 81.78 | 48.58 | 44 | 1641 | 16625 | 1728471 |
Withdrawal syndrome | 80.70 | 48.58 | 25 | 1660 | 2263 | 1742833 |
Bradypnoea | 74.93 | 48.58 | 16 | 1669 | 321 | 1744775 |
Altered state of consciousness | 74.10 | 48.58 | 26 | 1659 | 3471 | 1741625 |
Macrophages increased | 71.38 | 48.58 | 10 | 1675 | 8 | 1745088 |
Neuroleptic malignant syndrome | 68.98 | 48.58 | 24 | 1661 | 3124 | 1741972 |
Intentional self-injury | 68.83 | 48.58 | 23 | 1662 | 2650 | 1742446 |
Hepatitis | 65.28 | 48.58 | 26 | 1659 | 4929 | 1740167 |
Lactic acidosis | 60.97 | 48.58 | 25 | 1660 | 5104 | 1739992 |
Death | 58.27 | 48.58 | 71 | 1614 | 87372 | 1657724 |
Respiratory distress | 57.46 | 48.58 | 24 | 1661 | 5133 | 1739963 |
Cardiomegaly | 55.80 | 48.58 | 19 | 1666 | 2315 | 1742781 |
Coma scale abnormal | 55.68 | 48.58 | 14 | 1671 | 585 | 1744511 |
Dysarthria | 53.68 | 48.58 | 23 | 1662 | 5236 | 1739860 |
Foetal alcohol syndrome | 53.35 | 48.58 | 8 | 1677 | 15 | 1745081 |
Substance abuse | 53.02 | 48.58 | 15 | 1670 | 988 | 1744108 |
Thrombocytopenia | 52.08 | 48.58 | 36 | 1649 | 21213 | 1723883 |
Balance disorder | 51.47 | 48.58 | 23 | 1662 | 5789 | 1739307 |
Blood ethanol increased | 50.95 | 48.58 | 9 | 1676 | 62 | 1745034 |
Dextrocardia | 50.23 | 48.58 | 8 | 1677 | 26 | 1745070 |
Pulmonary oedema | 48.71 | 48.58 | 23 | 1662 | 6563 | 1738533 |
Depressed level of consciousness | 48.69 | 48.58 | 23 | 1662 | 6569 | 1738527 |
Source | Code | Description |
---|---|---|
ATC | N05CF01 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine related drugs |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D006993 | Hypnotics and Sedatives |
CHEBI has role | CHEBI:35488 | central nervous system depressant |
CHEBI has role | CHEBI:35717 | sedative |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Insomnia | indication | 193462001 | |
Suicidal thoughts | contraindication | 6471006 | |
Asthenia | contraindication | 13791008 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Hepatic failure | contraindication | 59927004 | |
Sleep automatism | contraindication | 247962006 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.95 | Basic |
pKa2 | 2.26 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-5/beta-3/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 7.28 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 6.58 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-3/beta-2/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 6.49 | WOMBAT-PK | DRUG LABEL | |||
GABA-A receptor alpha-1/beta-2/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 7.15 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-5/beta-2/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 7.28 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-5/beta-2/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 6.75 | WOMBAT-PK | DRUG LABEL | |||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE MODULATOR | Ki | 7.18 | WOMBAT-PK | DRUG LABEL | |||
GABA A receptor alpha-5/beta-3/gamma-3 | Ion channel | POSITIVE MODULATOR | Ki | 6.75 | WOMBAT-PK | DRUG LABEL | |||
GABA-A receptor; anion channel | Ion channel | IC50 | 7.54 | CHEMBL |
ID | Source |
---|---|
C0078847 | UMLSCUI |
D01372 | KEGG_DRUG |
03A5ORL08Q | UNII |
4462 | INN_ID |
321174005 | SNOMEDCT_US |
003775 | NDDF |
40001 | RXNORM |
395929002 | SNOMEDCT_US |
CHEMBL135400 | ChEMBL_ID |
DB01198 | DRUGBANK_ID |
CHEBI:32315 | CHEBI |
5735 | PUBCHEM_CID |
7430 | IUPHAR_LIGAND_ID |
C515050 | MESH_SUPPLEMENTAL_RECORD_UI |
None