zolpidem 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| hypnotics/sedatives, zolpidem derivatives | 2870 | 82626-48-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.08 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.47 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 72 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.54 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.70 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 16, 1992 | FDA | SANOFI AVENTIS US |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 947.66 | 9.95 | 1432 | 149956 | 144241 | 63193393 |
| Drug abuse | 764.26 | 9.95 | 903 | 150485 | 71615 | 63266019 |
| Intentional overdose | 726.85 | 9.95 | 890 | 150498 | 73262 | 63264372 |
| Suicide attempt | 537.65 | 9.95 | 694 | 150694 | 60224 | 63277410 |
| Somnambulism | 513.15 | 9.95 | 255 | 151133 | 5288 | 63332346 |
| Drug dependence | 507.58 | 9.95 | 440 | 150948 | 24043 | 63313591 |
| Contraindicated product administered | 448.15 | 9.95 | 16 | 151372 | 217632 | 63120002 |
| Drug intolerance | 390.62 | 9.95 | 125 | 151263 | 308536 | 63029098 |
| Synovitis | 380.44 | 9.95 | 15 | 151373 | 186903 | 63150731 |
| Hand deformity | 354.03 | 9.95 | 5 | 151383 | 159452 | 63178182 |
| Sopor | 334.90 | 9.95 | 334 | 151054 | 21830 | 63315804 |
| Amnesia | 334.86 | 9.95 | 528 | 150860 | 55057 | 63282577 |
| Systemic lupus erythematosus | 333.88 | 9.95 | 50 | 151338 | 208868 | 63128766 |
| Treatment failure | 333.83 | 9.95 | 41 | 151347 | 199002 | 63138632 |
| Joint swelling | 321.00 | 9.95 | 192 | 151196 | 327474 | 63010160 |
| Drug ineffective | 293.08 | 9.95 | 1392 | 149996 | 1043373 | 62294261 |
| Arthropathy | 291.78 | 9.95 | 98 | 151290 | 234694 | 63102940 |
| Infusion related reaction | 290.61 | 9.95 | 111 | 151277 | 245410 | 63092224 |
| Glossodynia | 289.99 | 9.95 | 41 | 151347 | 178835 | 63158799 |
| Intentional self-injury | 287.25 | 9.95 | 330 | 151058 | 25357 | 63312277 |
| Anxiety | 270.57 | 9.95 | 1131 | 150257 | 216410 | 63121224 |
| Off label use | 267.58 | 9.95 | 778 | 150610 | 673684 | 62663950 |
| Overdose | 242.88 | 9.95 | 713 | 150675 | 114365 | 63223269 |
| Pericarditis | 236.25 | 9.95 | 21 | 151367 | 131558 | 63206076 |
| Toxicity to various agents | 226.03 | 9.95 | 1175 | 150213 | 246075 | 63091559 |
| Wound | 225.08 | 9.95 | 56 | 151332 | 163207 | 63174427 |
| Somnolence | 221.29 | 9.95 | 928 | 150460 | 177757 | 63159877 |
| Abnormal sleep-related event | 217.77 | 9.95 | 79 | 151309 | 714 | 63336920 |
| Intentional product misuse | 214.69 | 9.95 | 459 | 150929 | 60458 | 63277176 |
| Alopecia | 211.62 | 9.95 | 298 | 151090 | 337238 | 63000396 |
| Depression | 204.50 | 9.95 | 969 | 150419 | 195523 | 63142111 |
| Maternal exposure during pregnancy | 198.93 | 9.95 | 141 | 151247 | 219921 | 63117713 |
| Rheumatoid arthritis | 194.51 | 9.95 | 191 | 151197 | 253628 | 63084006 |
| Swelling | 189.13 | 9.95 | 227 | 151161 | 275151 | 63062483 |
| Abdominal discomfort | 188.76 | 9.95 | 296 | 151092 | 320589 | 63017045 |
| Poisoning deliberate | 188.08 | 9.95 | 179 | 151209 | 11039 | 63326595 |
| Peripheral swelling | 185.01 | 9.95 | 217 | 151171 | 265725 | 63071909 |
| Lower respiratory tract infection | 179.24 | 9.95 | 47 | 151341 | 132260 | 63205374 |
| Hypersensitivity | 176.91 | 9.95 | 265 | 151123 | 292420 | 63045214 |
| Helicobacter infection | 171.54 | 9.95 | 13 | 151375 | 92772 | 63244862 |
| Poisoning | 170.27 | 9.95 | 186 | 151202 | 13514 | 63324120 |
| Coma | 160.59 | 9.95 | 424 | 150964 | 63940 | 63273694 |
| Drug withdrawal syndrome | 160.50 | 9.95 | 256 | 151132 | 26938 | 63310696 |
| Therapeutic product effect decreased | 155.45 | 9.95 | 139 | 151249 | 193048 | 63144586 |
| Fall | 154.90 | 9.95 | 1521 | 149867 | 390813 | 62946821 |
| Product use issue | 145.87 | 9.95 | 187 | 151201 | 220333 | 63117301 |
| Hepatic enzyme increased | 141.83 | 9.95 | 164 | 151224 | 202164 | 63135470 |
| Respiratory arrest | 140.06 | 9.95 | 267 | 151121 | 32378 | 63305256 |
| Suicidal ideation | 136.64 | 9.95 | 392 | 150996 | 62029 | 63275605 |
| Drug use disorder | 133.51 | 9.95 | 104 | 151284 | 4880 | 63332754 |
| Cardio-respiratory arrest | 131.69 | 9.95 | 377 | 151011 | 59582 | 63278052 |
| Discomfort | 131.58 | 9.95 | 123 | 151265 | 167251 | 63170383 |
| Rash | 128.82 | 9.95 | 797 | 150591 | 560074 | 62777560 |
| Abnormal behaviour | 126.85 | 9.95 | 202 | 151186 | 21224 | 63316410 |
| Folliculitis | 121.51 | 9.95 | 13 | 151375 | 70304 | 63267330 |
| Infection | 121.26 | 9.95 | 226 | 151162 | 228947 | 63108687 |
| Musculoskeletal stiffness | 118.54 | 9.95 | 160 | 151228 | 184458 | 63153176 |
| Loss of consciousness | 116.59 | 9.95 | 574 | 150814 | 117547 | 63220087 |
| Arthralgia | 116.53 | 9.95 | 838 | 150550 | 568872 | 62768762 |
| Muscle injury | 113.12 | 9.95 | 12 | 151376 | 65333 | 63272301 |
| Blister | 112.28 | 9.95 | 87 | 151301 | 129727 | 63207907 |
| Impaired driving ability | 107.74 | 9.95 | 88 | 151300 | 4423 | 63333211 |
| Sleep disorder due to general medical condition, insomnia type | 103.48 | 9.95 | 5 | 151383 | 52212 | 63285422 |
| Sleep-related eating disorder | 102.73 | 9.95 | 47 | 151341 | 804 | 63336830 |
| Affect lability | 99.78 | 9.95 | 128 | 151260 | 11023 | 63326611 |
| Agitation | 91.44 | 9.95 | 332 | 151056 | 59425 | 63278209 |
| Withdrawal syndrome | 88.80 | 9.95 | 166 | 151222 | 19831 | 63317803 |
| Hallucination | 88.53 | 9.95 | 310 | 151078 | 54507 | 63283127 |
| Therapeutic product effect incomplete | 87.98 | 9.95 | 101 | 151287 | 124955 | 63212679 |
| Insomnia | 87.91 | 9.95 | 841 | 150547 | 214411 | 63123223 |
| Mental status changes | 86.95 | 9.95 | 249 | 151139 | 39350 | 63298284 |
| Disorientation | 84.62 | 9.95 | 246 | 151142 | 39206 | 63298428 |
| Road traffic accident | 84.01 | 9.95 | 234 | 151154 | 36398 | 63301236 |
| Drug hypersensitivity | 83.96 | 9.95 | 418 | 150970 | 310269 | 63027365 |
| Restlessness | 83.82 | 9.95 | 204 | 151184 | 29249 | 63308385 |
| Intentional product use issue | 82.92 | 9.95 | 110 | 151278 | 127782 | 63209852 |
| Bradyphrenia | 80.26 | 9.95 | 91 | 151297 | 6889 | 63330745 |
| Mydriasis | 79.58 | 9.95 | 119 | 151269 | 11837 | 63325797 |
| Nasopharyngitis | 75.20 | 9.95 | 331 | 151057 | 253926 | 63083708 |
| Ill-defined disorder | 71.69 | 9.95 | 54 | 151334 | 81701 | 63255933 |
| Product substitution issue | 71.29 | 9.95 | 133 | 151255 | 15863 | 63321771 |
| Product use in unapproved indication | 71.01 | 9.95 | 206 | 151182 | 178874 | 63158760 |
| Delirium | 70.83 | 9.95 | 273 | 151115 | 50268 | 63287366 |
| Tremor | 70.37 | 9.95 | 548 | 150840 | 131691 | 63205943 |
| Carotid artery thrombosis | 69.89 | 9.95 | 56 | 151332 | 2738 | 63334896 |
| Condition aggravated | 68.98 | 9.95 | 620 | 150768 | 401597 | 62936037 |
| Drug abuser | 67.67 | 9.95 | 56 | 151332 | 2867 | 63334767 |
| Liver injury | 65.67 | 9.95 | 31 | 151357 | 60489 | 63277145 |
| Impaired healing | 65.64 | 9.95 | 89 | 151299 | 102453 | 63235181 |
| Cardiac arrest | 64.78 | 9.95 | 410 | 150978 | 92135 | 63245499 |
| Psoriatic arthropathy | 63.19 | 9.95 | 75 | 151313 | 91445 | 63246189 |
| Neurologic neglect syndrome | 62.72 | 9.95 | 52 | 151336 | 2669 | 63334965 |
| Dysarthria | 62.56 | 9.95 | 234 | 151154 | 42477 | 63295157 |
| Personality disorder | 62.17 | 9.95 | 73 | 151315 | 5738 | 63331896 |
| Dependence | 61.48 | 9.95 | 46 | 151342 | 2031 | 63335603 |
| Hyponatraemia | 60.80 | 9.95 | 466 | 150922 | 111434 | 63226200 |
| Drug detoxification | 58.67 | 9.95 | 24 | 151364 | 308 | 63337326 |
| Immobilisation prolonged | 58.22 | 9.95 | 18 | 151370 | 93 | 63337541 |
| Exposure during pregnancy | 57.33 | 9.95 | 185 | 151203 | 155362 | 63182272 |
| Confusional state | 56.26 | 9.95 | 833 | 150555 | 235547 | 63102087 |
| Psychomotor skills impaired | 56.14 | 9.95 | 46 | 151342 | 2322 | 63335312 |
| Parkinsonism | 55.81 | 9.95 | 94 | 151294 | 10345 | 63327289 |
| Altered state of consciousness | 53.79 | 9.95 | 157 | 151231 | 25073 | 63312561 |
| Pain | 53.68 | 9.95 | 1351 | 150037 | 739277 | 62598357 |
| Sleep talking | 53.60 | 9.95 | 32 | 151356 | 964 | 63336670 |
| Mental disorder | 53.08 | 9.95 | 159 | 151229 | 25760 | 63311874 |
| Miosis | 53.01 | 9.95 | 76 | 151312 | 7277 | 63330357 |
| Substance abuse | 52.45 | 9.95 | 61 | 151327 | 4746 | 63332888 |
| Drug withdrawal convulsions | 52.38 | 9.95 | 36 | 151352 | 1389 | 63336245 |
| Urinary retention | 52.10 | 9.95 | 175 | 151213 | 30126 | 63307508 |
| Adjustment disorder | 51.92 | 9.95 | 50 | 151338 | 3128 | 63334506 |
| Hip arthroplasty | 49.29 | 9.95 | 26 | 151362 | 47620 | 63290014 |
| Red blood cell sedimentation rate increased | 48.54 | 9.95 | 22 | 151366 | 43960 | 63293674 |
| Depressed level of consciousness | 48.49 | 9.95 | 283 | 151105 | 61795 | 63275839 |
| Gastrointestinal disorder | 47.73 | 9.95 | 157 | 151231 | 131082 | 63206552 |
| Disturbance in attention | 47.67 | 9.95 | 199 | 151189 | 37990 | 63299644 |
| Irritable bowel syndrome | 47.42 | 9.95 | 77 | 151311 | 82335 | 63255299 |
| Motor dysfunction | 47.36 | 9.95 | 89 | 151299 | 10672 | 63326962 |
| Listless | 46.73 | 9.95 | 45 | 151343 | 2815 | 63334819 |
| Rhabdomyolysis | 46.51 | 9.95 | 218 | 151170 | 43733 | 63293901 |
| Bradykinesia | 45.55 | 9.95 | 59 | 151329 | 5129 | 63332505 |
| Dissociative disorder | 45.55 | 9.95 | 21 | 151367 | 366 | 63337268 |
| Adverse drug reaction | 43.54 | 9.95 | 77 | 151311 | 79637 | 63257997 |
| Tardive dyskinesia | 43.40 | 9.95 | 75 | 151313 | 8427 | 63329207 |
| Type 2 diabetes mellitus | 43.38 | 9.95 | 53 | 151335 | 63815 | 63273819 |
| Emotional distress | 43.31 | 9.95 | 173 | 151215 | 32376 | 63305258 |
| Wheezing | 43.18 | 9.95 | 103 | 151285 | 95492 | 63242142 |
| Syncope | 42.71 | 9.95 | 448 | 150940 | 116937 | 63220697 |
| High risk sexual behaviour | 40.33 | 9.95 | 8 | 151380 | 0 | 63337634 |
| Hemiplegia | 39.67 | 9.95 | 76 | 151312 | 9247 | 63328387 |
| Stomatitis | 39.53 | 9.95 | 183 | 151205 | 138542 | 63199092 |
| Exposure via ingestion | 38.79 | 9.95 | 41 | 151347 | 2868 | 63334766 |
| Hypokalaemia | 38.16 | 9.95 | 397 | 150991 | 103407 | 63234227 |
| Drug screen positive | 37.85 | 9.95 | 45 | 151343 | 3584 | 63334050 |
| Initial insomnia | 37.76 | 9.95 | 59 | 151329 | 6098 | 63331536 |
| Dehydration | 37.42 | 9.95 | 601 | 150787 | 172753 | 63164881 |
| Sensory loss | 37.03 | 9.95 | 78 | 151310 | 10160 | 63327474 |
| Akathisia | 37.01 | 9.95 | 73 | 151315 | 9073 | 63328561 |
| Bradypnoea | 36.99 | 9.95 | 44 | 151344 | 3506 | 63334128 |
| Live birth | 36.86 | 9.95 | 8 | 151380 | 25622 | 63312012 |
| Coordination abnormal | 36.66 | 9.95 | 93 | 151295 | 13680 | 63323954 |
| Panic attack | 36.66 | 9.95 | 127 | 151261 | 22204 | 63315430 |
| Logorrhoea | 36.39 | 9.95 | 37 | 151351 | 2473 | 63335161 |
| Tachycardia | 36.20 | 9.95 | 436 | 150952 | 117720 | 63219914 |
| Mobility decreased | 35.61 | 9.95 | 158 | 151230 | 121001 | 63216633 |
| Eating disorder | 35.54 | 9.95 | 113 | 151275 | 18903 | 63318731 |
| Hallucination, visual | 35.45 | 9.95 | 114 | 151274 | 19184 | 63318450 |
| Premature delivery | 35.25 | 9.95 | 14 | 151374 | 30267 | 63307367 |
| Dysphagia | 35.06 | 9.95 | 344 | 151044 | 88241 | 63249393 |
| C-reactive protein increased | 34.63 | 9.95 | 113 | 151275 | 94594 | 63243040 |
| Skin haemorrhage | 34.32 | 9.95 | 75 | 151313 | 10019 | 63327615 |
| Blood pressure fluctuation | 34.11 | 9.95 | 36 | 151352 | 46281 | 63291353 |
| Urticaria | 33.67 | 9.95 | 244 | 151144 | 165558 | 63172076 |
| Inflammation | 33.05 | 9.95 | 94 | 151294 | 82179 | 63255455 |
| General physical health deterioration | 32.49 | 9.95 | 315 | 151073 | 201087 | 63136547 |
| Hallucination, auditory | 32.49 | 9.95 | 85 | 151303 | 12739 | 63324895 |
| Vertigo | 32.28 | 9.95 | 249 | 151139 | 59638 | 63277996 |
| Head injury | 32.06 | 9.95 | 140 | 151248 | 27256 | 63310378 |
| Knee arthroplasty | 31.79 | 9.95 | 50 | 151338 | 54156 | 63283478 |
| Victim of sexual abuse | 31.76 | 9.95 | 20 | 151368 | 664 | 63336970 |
| Joint range of motion decreased | 31.67 | 9.95 | 19 | 151369 | 32409 | 63305225 |
| Homicide | 30.65 | 9.95 | 16 | 151372 | 369 | 63337265 |
| Irritability | 30.51 | 9.95 | 153 | 151235 | 31541 | 63306093 |
| Abnormal dreams | 30.09 | 9.95 | 73 | 151315 | 10443 | 63327191 |
| Grip strength decreased | 30.00 | 9.95 | 8 | 151380 | 22279 | 63315355 |
| Hypotension | 29.24 | 9.95 | 854 | 150534 | 271750 | 63065884 |
| Blood cholesterol increased | 29.24 | 9.95 | 120 | 151268 | 93912 | 63243722 |
| Drug interaction | 29.18 | 9.95 | 734 | 150654 | 228397 | 63109237 |
| Persistent genital arousal disorder | 28.99 | 9.95 | 14 | 151374 | 272 | 63337362 |
| Pruritus | 28.92 | 9.95 | 649 | 150739 | 360804 | 62976830 |
| Nightmare | 28.81 | 9.95 | 106 | 151282 | 19088 | 63318546 |
| Influenza like illness | 28.67 | 9.95 | 264 | 151124 | 66560 | 63271074 |
| Blood pressure systolic increased | 28.48 | 9.95 | 43 | 151345 | 47354 | 63290280 |
| Multiple drug therapy | 28.23 | 9.95 | 39 | 151349 | 3607 | 63334027 |
| Illusion | 27.95 | 9.95 | 22 | 151366 | 1048 | 63336586 |
| COVID-19 | 27.79 | 9.95 | 157 | 151231 | 112946 | 63224688 |
| Bulimia nervosa | 27.53 | 9.95 | 16 | 151372 | 458 | 63337176 |
| Prescription drug used without a prescription | 27.25 | 9.95 | 31 | 151357 | 2355 | 63335279 |
| Device expulsion | 27.02 | 9.95 | 26 | 151362 | 34896 | 63302738 |
| Sinus tachycardia | 26.88 | 9.95 | 122 | 151266 | 24146 | 63313488 |
| Alcohol abuse | 26.43 | 9.95 | 29 | 151359 | 2117 | 63335517 |
| Mania | 26.40 | 9.95 | 77 | 151311 | 12290 | 63325344 |
| Anaphylactic reaction | 26.20 | 9.95 | 76 | 151312 | 66024 | 63271610 |
| Apathy | 26.19 | 9.95 | 62 | 151326 | 8732 | 63328902 |
| Cholecystitis chronic | 25.56 | 9.95 | 68 | 151320 | 10293 | 63327341 |
| Peptic ulcer | 25.45 | 9.95 | 42 | 151346 | 4545 | 63333089 |
| Rheumatoid nodule | 25.40 | 9.95 | 5 | 151383 | 17150 | 63320484 |
| Self-medication | 25.17 | 9.95 | 32 | 151356 | 2731 | 63334903 |
| Deep vein thrombosis | 25.13 | 9.95 | 308 | 151080 | 83492 | 63254142 |
| Obstructive airways disorder | 25.05 | 9.95 | 9 | 151379 | 20690 | 63316944 |
| Unresponsive to stimuli | 25.01 | 9.95 | 152 | 151236 | 33664 | 63303970 |
| Memory impairment | 24.99 | 9.95 | 368 | 151020 | 103890 | 63233744 |
| Urinary hesitation | 24.78 | 9.95 | 29 | 151359 | 2271 | 63335363 |
| Multiple sclerosis relapse | 24.72 | 9.95 | 199 | 151189 | 48279 | 63289355 |
| Sinus congestion | 24.65 | 9.95 | 97 | 151291 | 18026 | 63319608 |
| Incoherent | 24.49 | 9.95 | 41 | 151347 | 4489 | 63333145 |
| Foreign body | 24.40 | 9.95 | 29 | 151359 | 2309 | 63335325 |
| Therapy non-responder | 24.14 | 9.95 | 96 | 151292 | 75805 | 63261829 |
| Hyperhidrosis | 24.06 | 9.95 | 376 | 151012 | 107460 | 63230174 |
| Hepatitis B DNA increased | 23.62 | 9.95 | 12 | 151376 | 261 | 63337373 |
| Fatigue | 23.49 | 9.95 | 1812 | 149576 | 886216 | 62451418 |
| Respiratory depression | 23.39 | 9.95 | 79 | 151309 | 13636 | 63323998 |
| Reduced facial expression | 23.23 | 9.95 | 26 | 151362 | 1940 | 63335694 |
| Drug resistance | 23.01 | 9.95 | 13 | 151375 | 22920 | 63314714 |
| Asthenia | 22.45 | 9.95 | 1124 | 150264 | 382480 | 62955154 |
| Imprisonment | 22.44 | 9.95 | 11 | 151377 | 221 | 63337413 |
| Aggression | 22.31 | 9.95 | 113 | 151275 | 23385 | 63314249 |
| Multiple sclerosis | 22.30 | 9.95 | 116 | 151272 | 24256 | 63313378 |
| Labelled drug-food interaction issue | 22.23 | 9.95 | 6 | 151382 | 17 | 63337617 |
| Aspartate aminotransferase increased | 22.17 | 9.95 | 320 | 151068 | 89957 | 63247677 |
| Dysuria | 22.08 | 9.95 | 147 | 151241 | 33591 | 63304043 |
| Laryngeal pain | 22.08 | 9.95 | 39 | 151349 | 4459 | 63333175 |
| Hiatus hernia | 22.04 | 9.95 | 106 | 151282 | 21488 | 63316146 |
| Drug tolerance | 21.80 | 9.95 | 50 | 151338 | 6899 | 63330735 |
| Hangover | 21.71 | 9.95 | 23 | 151365 | 1613 | 63336021 |
| Feeling abnormal | 21.51 | 9.95 | 484 | 150904 | 147908 | 63189726 |
| Psychomotor hyperactivity | 21.44 | 9.95 | 65 | 151323 | 10598 | 63327036 |
| Peripheral circulatory failure | 21.28 | 9.95 | 18 | 151370 | 950 | 63336684 |
| Product complaint | 21.16 | 9.95 | 73 | 151315 | 12736 | 63324898 |
| Seizure | 20.95 | 9.95 | 438 | 150950 | 132196 | 63205438 |
| Bone erosion | 20.94 | 9.95 | 8 | 151380 | 17709 | 63319925 |
| Anger | 20.58 | 9.95 | 71 | 151317 | 12385 | 63325249 |
| Feeling drunk | 20.44 | 9.95 | 36 | 151352 | 4106 | 63333528 |
| Alcohol use | 20.41 | 9.95 | 25 | 151363 | 2054 | 63335580 |
| Pulmonary fibrosis | 20.37 | 9.95 | 40 | 151348 | 39769 | 63297865 |
| Myelosuppression | 20.33 | 9.95 | 16 | 151372 | 23687 | 63313947 |
| Vision blurred | 20.31 | 9.95 | 320 | 151068 | 91604 | 63246030 |
| Macular degeneration | 20.23 | 9.95 | 17 | 151371 | 24359 | 63313275 |
| Major depression | 20.16 | 9.95 | 53 | 151335 | 7965 | 63329669 |
| Behaviour disorder | 20.10 | 9.95 | 31 | 151357 | 3168 | 63334466 |
| Neutropenia | 20.03 | 9.95 | 295 | 151093 | 174710 | 63162924 |
| Respiratory tract congestion | 20.01 | 9.95 | 90 | 151298 | 17742 | 63319892 |
| Cognitive disorder | 19.81 | 9.95 | 212 | 151176 | 55603 | 63282031 |
| Blood pressure systolic abnormal | 19.61 | 9.95 | 4 | 151384 | 13382 | 63324252 |
| Dyspnoea | 19.61 | 9.95 | 1336 | 150052 | 659977 | 62677657 |
| Serotonin syndrome | 19.39 | 9.95 | 126 | 151262 | 28556 | 63309078 |
| Crying | 19.26 | 9.95 | 108 | 151280 | 23235 | 63314399 |
| Sinus disorder | 19.21 | 9.95 | 112 | 151276 | 24441 | 63313193 |
| Tension | 18.88 | 9.95 | 30 | 151358 | 3145 | 63334489 |
| Panic disorder | 18.67 | 9.95 | 27 | 151361 | 2606 | 63335028 |
| Disinhibition | 18.56 | 9.95 | 16 | 151372 | 867 | 63336767 |
| Muscle rigidity | 18.53 | 9.95 | 65 | 151323 | 11435 | 63326199 |
| Diplopia | 18.41 | 9.95 | 108 | 151280 | 23620 | 63314014 |
| Aortic valve calcification | 18.37 | 9.95 | 13 | 151375 | 526 | 63337108 |
| Sneezing | 18.28 | 9.95 | 89 | 151299 | 18129 | 63319505 |
| Dementia | 18.28 | 9.95 | 91 | 151297 | 18703 | 63318931 |
| Anterograde amnesia | 18.20 | 9.95 | 13 | 151375 | 534 | 63337100 |
| Affective disorder | 17.94 | 9.95 | 43 | 151345 | 6103 | 63331531 |
| Inadequate analgesia | 17.77 | 9.95 | 28 | 151360 | 2915 | 63334719 |
| Facial nerve disorder | 17.74 | 9.95 | 13 | 151375 | 556 | 63337078 |
| Anhedonia | 17.65 | 9.95 | 62 | 151326 | 10912 | 63326722 |
| Panniculitis | 17.54 | 9.95 | 3 | 151385 | 11382 | 63326252 |
| Left ventricular hypertrophy | 17.51 | 9.95 | 39 | 151349 | 5276 | 63332358 |
| Blood potassium decreased | 17.51 | 9.95 | 165 | 151223 | 41861 | 63295773 |
| Blood pressure diastolic decreased | 17.45 | 9.95 | 17 | 151371 | 22689 | 63314945 |
| Psychotic disorder | 17.41 | 9.95 | 113 | 151275 | 25599 | 63312035 |
| Performance fear | 17.40 | 9.95 | 4 | 151384 | 4 | 63337630 |
| Cough | 17.26 | 9.95 | 549 | 150839 | 292194 | 63045440 |
| Hypoglycaemia | 17.24 | 9.95 | 219 | 151169 | 59846 | 63277788 |
| Catatonia | 17.24 | 9.95 | 35 | 151353 | 4442 | 63333192 |
| Femoral neck fracture | 17.18 | 9.95 | 52 | 151336 | 8471 | 63329163 |
| Legal problem | 17.01 | 9.95 | 5 | 151383 | 21 | 63337613 |
| Decreased interest | 17.00 | 9.95 | 29 | 151359 | 3225 | 63334409 |
| Depressive symptom | 16.91 | 9.95 | 33 | 151355 | 4069 | 63333565 |
| Prescribed overdose | 16.89 | 9.95 | 35 | 151353 | 34118 | 63303516 |
| Creatinine renal clearance decreased | 16.72 | 9.95 | 9 | 151379 | 16299 | 63321335 |
| Sinusitis | 16.70 | 9.95 | 412 | 150976 | 226241 | 63111393 |
| Arterial occlusive disease | 16.66 | 9.95 | 41 | 151347 | 5917 | 63331717 |
| Accidental poisoning | 16.59 | 9.95 | 13 | 151375 | 615 | 63337019 |
| Fibromyalgia | 16.48 | 9.95 | 118 | 151270 | 80302 | 63257332 |
| Compulsive shopping | 16.45 | 9.95 | 14 | 151374 | 745 | 63336889 |
| Palpitations | 16.39 | 9.95 | 368 | 151020 | 112402 | 63225232 |
| Coagulation factor V level decreased | 16.27 | 9.95 | 10 | 151378 | 318 | 63337316 |
| Euphoric mood | 16.26 | 9.95 | 36 | 151352 | 4851 | 63332783 |
| Drug tolerance increased | 16.06 | 9.95 | 9 | 151379 | 240 | 63337394 |
| Genotype drug resistance test positive | 16.06 | 9.95 | 11 | 151377 | 422 | 63337212 |
| Lethargy | 15.99 | 9.95 | 204 | 151184 | 55803 | 63281831 |
| Tracheal atresia | 15.99 | 9.95 | 5 | 151383 | 27 | 63337607 |
| Loss of proprioception | 15.99 | 9.95 | 11 | 151377 | 425 | 63337209 |
| Inappropriate antidiuretic hormone secretion | 15.85 | 9.95 | 76 | 151312 | 15386 | 63322248 |
| Immunodeficiency | 15.76 | 9.95 | 15 | 151373 | 20239 | 63317395 |
| Inappropriate schedule of product administration | 15.76 | 9.95 | 165 | 151223 | 103800 | 63233834 |
| Angioedema | 15.68 | 9.95 | 60 | 151328 | 47905 | 63289729 |
| Visual acuity reduced | 15.45 | 9.95 | 97 | 151291 | 21729 | 63315905 |
| Emotional poverty | 15.44 | 9.95 | 10 | 151378 | 349 | 63337285 |
| Prothrombin time prolonged | 15.36 | 9.95 | 54 | 151334 | 9510 | 63328124 |
| Pulmonary vasculitis | 15.23 | 9.95 | 7 | 151381 | 121 | 63337513 |
| Brain contusion | 15.22 | 9.95 | 12 | 151376 | 573 | 63337061 |
| Cholecystectomy | 15.22 | 9.95 | 58 | 151330 | 10619 | 63327015 |
| Protrusion tongue | 15.16 | 9.95 | 10 | 151378 | 360 | 63337274 |
| Neuroglycopenia | 15.08 | 9.95 | 11 | 151377 | 467 | 63337167 |
| Prothrombin time shortened | 14.94 | 9.95 | 21 | 151367 | 1974 | 63335660 |
| Arthritis | 14.84 | 9.95 | 191 | 151197 | 115730 | 63221904 |
| Electrocardiogram QT prolonged | 14.60 | 9.95 | 211 | 151177 | 59319 | 63278315 |
| Psychomotor retardation | 14.60 | 9.95 | 30 | 151358 | 3840 | 63333794 |
| Constipation | 14.59 | 9.95 | 666 | 150722 | 224277 | 63113357 |
| Adverse event | 14.40 | 9.95 | 98 | 151290 | 67461 | 63270173 |
| Blood urea increased | 14.39 | 9.95 | 110 | 151278 | 26269 | 63311365 |
| Bursitis | 14.38 | 9.95 | 43 | 151345 | 36998 | 63300636 |
| Therapeutic response unexpected | 14.31 | 9.95 | 85 | 151303 | 18674 | 63318960 |
| Self-injurious ideation | 14.29 | 9.95 | 24 | 151364 | 2635 | 63334999 |
| Neurogenic bladder | 14.25 | 9.95 | 27 | 151361 | 3258 | 63334376 |
| Erythema | 14.19 | 9.95 | 315 | 151073 | 175436 | 63162198 |
| Spinal rod insertion | 14.18 | 9.95 | 4 | 151384 | 14 | 63337620 |
| Pyrexia | 14.16 | 9.95 | 949 | 150439 | 469529 | 62868105 |
| Terminal insomnia | 14.01 | 9.95 | 13 | 151375 | 776 | 63336858 |
| Intervertebral disc degeneration | 13.79 | 9.95 | 74 | 151314 | 15658 | 63321976 |
| Drug diversion | 13.79 | 9.95 | 14 | 151374 | 934 | 63336700 |
| Hemiparesis | 13.79 | 9.95 | 99 | 151289 | 23183 | 63314451 |
| Social anxiety disorder | 13.78 | 9.95 | 10 | 151378 | 421 | 63337213 |
| Fear | 13.71 | 9.95 | 74 | 151314 | 15692 | 63321942 |
| Bipolar disorder | 13.70 | 9.95 | 46 | 151342 | 7914 | 63329720 |
| Hepatotoxicity | 13.67 | 9.95 | 44 | 151344 | 36997 | 63300637 |
| Skin abrasion | 13.56 | 9.95 | 51 | 151337 | 9278 | 63328356 |
| Cardiomegaly | 13.55 | 9.95 | 80 | 151308 | 17534 | 63320100 |
| Lupus-like syndrome | 13.53 | 9.95 | 10 | 151378 | 15285 | 63322349 |
| Mood swings | 13.48 | 9.95 | 82 | 151306 | 18166 | 63319468 |
| Persecutory delusion | 13.45 | 9.95 | 24 | 151364 | 2766 | 63334868 |
| Blood creatine phosphokinase increased | 13.45 | 9.95 | 121 | 151267 | 30309 | 63307325 |
| Spinal osteoarthritis | 13.43 | 9.95 | 75 | 151313 | 16111 | 63321523 |
| Cerebral atrophy | 13.27 | 9.95 | 34 | 151354 | 5032 | 63332602 |
| Intravascular haemolysis | 13.21 | 9.95 | 9 | 151379 | 342 | 63337292 |
| Atelectasis | 13.10 | 9.95 | 92 | 151296 | 21391 | 63316243 |
| Nervousness | 13.09 | 9.95 | 122 | 151266 | 30857 | 63306777 |
| Benzodiazepine drug level | 13.05 | 9.95 | 3 | 151385 | 3 | 63337631 |
| Aphasia | 12.97 | 9.95 | 128 | 151260 | 32872 | 63304762 |
| Cholelithiasis | 12.97 | 9.95 | 161 | 151227 | 43764 | 63293870 |
| Neonatal behavioural syndrome | 12.91 | 9.95 | 5 | 151383 | 55 | 63337579 |
| Anorexia nervosa | 12.80 | 9.95 | 8 | 151380 | 262 | 63337372 |
| Fibrocystic breast disease | 12.79 | 9.95 | 15 | 151373 | 1177 | 63336457 |
| Sedation | 12.67 | 9.95 | 145 | 151243 | 38664 | 63298970 |
| Dysphoria | 12.67 | 9.95 | 33 | 151355 | 4933 | 63332701 |
| Accidental overdose | 12.60 | 9.95 | 97 | 151291 | 23212 | 63314422 |
| Homicidal ideation | 12.47 | 9.95 | 18 | 151370 | 1734 | 63335900 |
| Automatism | 12.45 | 9.95 | 5 | 151383 | 61 | 63337573 |
| Gastric polyps | 12.38 | 9.95 | 26 | 151362 | 3379 | 63334255 |
| Head discomfort | 12.38 | 9.95 | 64 | 151324 | 13351 | 63324283 |
| Spleen congestion | 12.31 | 9.95 | 6 | 151382 | 119 | 63337515 |
| Drug dependence, antepartum | 12.30 | 9.95 | 4 | 151384 | 25 | 63337609 |
| Restless legs syndrome | 12.28 | 9.95 | 81 | 151307 | 18450 | 63319184 |
| Diarrhoea | 12.19 | 9.95 | 1507 | 149881 | 713859 | 62623775 |
| Secretion discharge | 12.18 | 9.95 | 7 | 151381 | 12224 | 63325410 |
| Mucosal inflammation | 12.15 | 9.95 | 64 | 151324 | 46864 | 63290770 |
| Generalised tonic-clonic seizure | 12.12 | 9.95 | 114 | 151274 | 28902 | 63308732 |
| Multiple injuries | 12.11 | 9.95 | 18 | 151370 | 1780 | 63335854 |
| Hypotonia | 12.07 | 9.95 | 49 | 151339 | 9236 | 63328398 |
| Periventricular leukomalacia | 12.05 | 9.95 | 6 | 151382 | 125 | 63337509 |
| Autonomic nervous system imbalance | 12.02 | 9.95 | 23 | 151365 | 2795 | 63334839 |
| Extrapyramidal disorder | 12.00 | 9.95 | 63 | 151325 | 13221 | 63324413 |
| Vertigo CNS origin | 11.91 | 9.95 | 4 | 151384 | 28 | 63337606 |
| Osteoarthritis | 11.87 | 9.95 | 158 | 151230 | 95185 | 63242449 |
| Transient ischaemic attack | 11.85 | 9.95 | 140 | 151248 | 37613 | 63300021 |
| Suicidal behaviour | 11.83 | 9.95 | 22 | 151366 | 2617 | 63335017 |
| Dreamy state | 11.79 | 9.95 | 4 | 151384 | 29 | 63337605 |
| Ecchymosis | 11.71 | 9.95 | 55 | 151333 | 11039 | 63326595 |
| Spondylolisthesis | 11.71 | 9.95 | 26 | 151362 | 3510 | 63334124 |
| Toxic epidermal necrolysis | 11.67 | 9.95 | 27 | 151361 | 25307 | 63312327 |
| Drop attacks | 11.66 | 9.95 | 11 | 151377 | 671 | 63336963 |
| Thirst | 11.61 | 9.95 | 65 | 151323 | 13976 | 63323658 |
| Speech disorder | 11.60 | 9.95 | 148 | 151240 | 40481 | 63297153 |
| Waxy flexibility | 11.59 | 9.95 | 6 | 151382 | 136 | 63337498 |
| Labelled drug-drug interaction medication error | 11.55 | 9.95 | 9 | 151379 | 13390 | 63324244 |
| Stupor | 11.52 | 9.95 | 29 | 151359 | 4246 | 63333388 |
| Amnestic disorder | 11.36 | 9.95 | 8 | 151380 | 321 | 63337313 |
| Alanine aminotransferase increased | 11.35 | 9.95 | 326 | 151062 | 103444 | 63234190 |
| Housebound | 11.26 | 9.95 | 7 | 151381 | 227 | 63337407 |
| Blood alkaline phosphatase increased | 11.22 | 9.95 | 154 | 151234 | 42813 | 63294821 |
| Ventricular fibrillation | 11.22 | 9.95 | 57 | 151331 | 11810 | 63325824 |
| Prescription form tampering | 11.20 | 9.95 | 10 | 151378 | 568 | 63337066 |
| Haemangioma congenital | 11.18 | 9.95 | 9 | 151379 | 443 | 63337191 |
| Dyskinesia | 11.10 | 9.95 | 121 | 151267 | 31881 | 63305753 |
| Colitis ulcerative | 11.08 | 9.95 | 29 | 151359 | 26062 | 63311572 |
| Foot deformity | 11.05 | 9.95 | 32 | 151356 | 27821 | 63309813 |
| Injection site reaction | 10.98 | 9.95 | 88 | 151300 | 58436 | 63279198 |
| Transplant rejection | 10.98 | 9.95 | 6 | 151382 | 10774 | 63326860 |
| Neurological examination normal | 10.94 | 9.95 | 4 | 151384 | 37 | 63337597 |
| Diverticulum | 10.92 | 9.95 | 57 | 151331 | 11934 | 63325700 |
| Coma scale abnormal | 10.92 | 9.95 | 32 | 151356 | 5121 | 63332513 |
| Hyperlipidaemia | 10.89 | 9.95 | 82 | 151306 | 19489 | 63318145 |
| Asphyxia | 10.89 | 9.95 | 36 | 151352 | 6145 | 63331489 |
| Leukocytosis | 10.89 | 9.95 | 102 | 151286 | 25833 | 63311801 |
| Atrioventricular block first degree | 10.77 | 9.95 | 40 | 151348 | 7233 | 63330401 |
| Cytomegalovirus infection | 10.76 | 9.95 | 21 | 151367 | 20931 | 63316703 |
| Hepatosplenomegaly | 10.74 | 9.95 | 21 | 151367 | 2593 | 63335041 |
| Mood altered | 10.73 | 9.95 | 66 | 151322 | 14677 | 63322957 |
| Dizziness | 10.67 | 9.95 | 1176 | 150212 | 428749 | 62908885 |
| Skin exfoliation | 10.66 | 9.95 | 153 | 151235 | 42949 | 63294685 |
| Injury | 10.63 | 9.95 | 239 | 151149 | 73008 | 63264626 |
| Neurotoxicity | 10.61 | 9.95 | 15 | 151373 | 16975 | 63320659 |
| Trance | 10.58 | 9.95 | 4 | 151384 | 41 | 63337593 |
| Sciatica | 10.54 | 9.95 | 44 | 151344 | 34280 | 63303354 |
| Hypokinesia | 10.53 | 9.95 | 63 | 151325 | 13873 | 63323761 |
| Depression suicidal | 10.53 | 9.95 | 17 | 151371 | 1806 | 63335828 |
| Pelvic fracture | 10.51 | 9.95 | 61 | 151327 | 13287 | 63324347 |
| Accidental exposure to product | 10.50 | 9.95 | 32 | 151356 | 27373 | 63310261 |
| Flat affect | 10.47 | 9.95 | 15 | 151373 | 1435 | 63336199 |
| Dysgeusia | 10.46 | 9.95 | 163 | 151225 | 46547 | 63291087 |
| Renal impairment | 10.43 | 9.95 | 148 | 151240 | 88207 | 63249427 |
| Barrett's oesophagus | 10.39 | 9.95 | 10 | 151378 | 625 | 63337009 |
| Pneumonia aspiration | 10.37 | 9.95 | 127 | 151261 | 34413 | 63303221 |
| Dental caries | 10.35 | 9.95 | 52 | 151336 | 10727 | 63326907 |
| Intervertebral disc protrusion | 10.33 | 9.95 | 94 | 151294 | 23615 | 63314019 |
| Lip dry | 10.33 | 9.95 | 13 | 151375 | 15457 | 63322177 |
| Verbal abuse | 10.31 | 9.95 | 5 | 151383 | 98 | 63337536 |
| Lymphatic disorder | 10.31 | 9.95 | 8 | 151380 | 373 | 63337261 |
| Ischaemic cardiomyopathy | 10.30 | 9.95 | 20 | 151368 | 2457 | 63335177 |
| Eustachian tube disorder | 10.27 | 9.95 | 5 | 151383 | 99 | 63337535 |
| Heart rate decreased | 10.26 | 9.95 | 65 | 151323 | 45495 | 63292139 |
| Malnutrition | 10.22 | 9.95 | 67 | 151321 | 15231 | 63322403 |
| Gangrene | 10.20 | 9.95 | 35 | 151353 | 6088 | 63331546 |
| Drug withdrawal syndrome neonatal | 10.16 | 9.95 | 18 | 151370 | 2063 | 63335571 |
| Herpes zoster | 10.14 | 9.95 | 137 | 151251 | 82325 | 63255309 |
| Cerebrovascular accident | 10.12 | 9.95 | 333 | 151055 | 107691 | 63229943 |
| Blastocystis infection | 10.10 | 9.95 | 4 | 151384 | 47 | 63337587 |
| Stress cardiomyopathy | 10.09 | 9.95 | 47 | 151341 | 9403 | 63328231 |
| Enthesopathy | 10.00 | 9.95 | 4 | 151384 | 8610 | 63329024 |
| Galactorrhoea | 9.98 | 9.95 | 27 | 151361 | 4128 | 63333506 |
| Optic disc haemorrhage | 9.96 | 9.95 | 5 | 151383 | 106 | 63337528 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Somnambulism | 564.21 | 10.23 | 230 | 85463 | 2842 | 34868396 |
| Completed suicide | 526.38 | 10.23 | 897 | 84796 | 97271 | 34773967 |
| Drug dependence | 337.97 | 10.23 | 354 | 85339 | 23863 | 34847375 |
| Intentional overdose | 319.85 | 10.23 | 461 | 85232 | 43213 | 34828025 |
| Amnesia | 248.63 | 10.23 | 316 | 85377 | 26247 | 34844991 |
| Drug abuse | 244.62 | 10.23 | 661 | 85032 | 98435 | 34772803 |
| Off label use | 201.04 | 10.23 | 459 | 85234 | 419065 | 34452173 |
| Suicide attempt | 177.79 | 10.23 | 333 | 85360 | 38783 | 34832455 |
| Road traffic accident | 157.60 | 10.23 | 204 | 85489 | 17246 | 34853992 |
| Intentional self-injury | 137.07 | 10.23 | 169 | 85524 | 13602 | 34857636 |
| Poisoning | 120.01 | 10.23 | 149 | 85544 | 12077 | 34859161 |
| Delirium | 117.06 | 10.23 | 302 | 85391 | 43689 | 34827549 |
| Confusional state | 111.30 | 10.23 | 668 | 85025 | 143492 | 34727746 |
| Drug withdrawal syndrome | 109.61 | 10.23 | 184 | 85509 | 19650 | 34851588 |
| Insomnia | 109.12 | 10.23 | 524 | 85169 | 103383 | 34767855 |
| Suicidal ideation | 108.21 | 10.23 | 278 | 85415 | 40110 | 34831128 |
| Overdose | 105.78 | 10.23 | 473 | 85220 | 90586 | 34780652 |
| Respiratory arrest | 103.63 | 10.23 | 219 | 85474 | 27824 | 34843414 |
| Sopor | 103.57 | 10.23 | 138 | 85555 | 11998 | 34859240 |
| Impaired driving ability | 98.60 | 10.23 | 68 | 85625 | 2565 | 34868673 |
| Somnolence | 92.25 | 10.23 | 525 | 85168 | 110591 | 34760647 |
| Abnormal sleep-related event | 87.83 | 10.23 | 36 | 85657 | 451 | 34870787 |
| Disorientation | 87.41 | 10.23 | 227 | 85466 | 32961 | 34838277 |
| Anxiety | 84.65 | 10.23 | 473 | 85220 | 98955 | 34772283 |
| Depression | 81.39 | 10.23 | 460 | 85233 | 96638 | 34774600 |
| Homicide | 76.12 | 10.23 | 40 | 85653 | 909 | 34870329 |
| Sleep-related eating disorder | 75.29 | 10.23 | 28 | 85665 | 265 | 34870973 |
| Abnormal behaviour | 73.30 | 10.23 | 178 | 85515 | 24791 | 34846447 |
| Product use in unapproved indication | 70.42 | 10.23 | 112 | 85581 | 117387 | 34753851 |
| Automatism | 68.08 | 10.23 | 21 | 85672 | 104 | 34871134 |
| Drug ineffective | 65.18 | 10.23 | 762 | 84931 | 455989 | 34415249 |
| Parasomnia | 59.96 | 10.23 | 26 | 85667 | 378 | 34870860 |
| Gun shot wound | 59.16 | 10.23 | 36 | 85657 | 1092 | 34870146 |
| Drug use disorder | 57.95 | 10.23 | 61 | 85632 | 4130 | 34867108 |
| Bradyphrenia | 54.51 | 10.23 | 63 | 85630 | 4735 | 34866503 |
| Restlessness | 53.95 | 10.23 | 161 | 85532 | 25321 | 34845917 |
| Drug abuser | 53.69 | 10.23 | 57 | 85636 | 3897 | 34867341 |
| Coma | 52.77 | 10.23 | 237 | 85456 | 45441 | 34825797 |
| Intentional product misuse | 52.20 | 10.23 | 236 | 85457 | 45375 | 34825863 |
| Agitation | 47.43 | 10.23 | 271 | 85422 | 57128 | 34814110 |
| Cardio-respiratory arrest | 47.02 | 10.23 | 263 | 85430 | 55010 | 34816228 |
| Poisoning deliberate | 46.33 | 10.23 | 75 | 85618 | 7769 | 34863469 |
| Fall | 44.38 | 10.23 | 721 | 84972 | 202164 | 34669074 |
| Thinking abnormal | 43.72 | 10.23 | 64 | 85629 | 6073 | 34865165 |
| Aggression | 43.39 | 10.23 | 200 | 85493 | 38764 | 34832474 |
| Toxicity to various agents | 42.70 | 10.23 | 709 | 84984 | 199653 | 34671585 |
| Withdrawal syndrome | 42.26 | 10.23 | 94 | 85599 | 12361 | 34858877 |
| Therapeutic product effect incomplete | 38.71 | 10.23 | 40 | 85653 | 50501 | 34820737 |
| Dissociative disorder | 38.28 | 10.23 | 20 | 85673 | 449 | 34870789 |
| Memory impairment | 38.09 | 10.23 | 208 | 85485 | 43110 | 34828128 |
| Loss of consciousness | 37.16 | 10.23 | 337 | 85356 | 82330 | 34788908 |
| Antidepressant drug level above therapeutic | 37.06 | 10.23 | 16 | 85677 | 230 | 34871008 |
| Hallucination | 36.72 | 10.23 | 234 | 85459 | 51264 | 34819974 |
| Dependence | 34.59 | 10.23 | 26 | 85667 | 1124 | 34870114 |
| Analgesic drug level above therapeutic | 33.37 | 10.23 | 16 | 85677 | 297 | 34870941 |
| Myelosuppression | 33.36 | 10.23 | 4 | 85689 | 19261 | 34851977 |
| Lower respiratory tract infection | 33.28 | 10.23 | 18 | 85675 | 31619 | 34839619 |
| Persistent depressive disorder | 32.07 | 10.23 | 16 | 85677 | 325 | 34870913 |
| Oedematous pancreatitis | 31.69 | 10.23 | 18 | 85675 | 479 | 34870759 |
| Legal problem | 31.28 | 10.23 | 13 | 85680 | 169 | 34871069 |
| Multiple organ dysfunction syndrome | 30.87 | 10.23 | 91 | 85602 | 76475 | 34794763 |
| Panic attack | 30.68 | 10.23 | 70 | 85623 | 9362 | 34861876 |
| Nightmare | 29.59 | 10.23 | 90 | 85603 | 14301 | 34856937 |
| Rheumatoid arthritis | 29.58 | 10.23 | 30 | 85663 | 38208 | 34833030 |
| Hypokinesia | 28.99 | 10.23 | 66 | 85627 | 8814 | 34862424 |
| Initial insomnia | 28.94 | 10.23 | 37 | 85656 | 3087 | 34868151 |
| Cytomegalovirus infection | 28.79 | 10.23 | 14 | 85679 | 26121 | 34845117 |
| Acute kidney injury | 28.71 | 10.23 | 551 | 85142 | 304437 | 34566801 |
| Death | 28.71 | 10.23 | 750 | 84943 | 397299 | 34473939 |
| Anterograde amnesia | 28.27 | 10.23 | 12 | 85681 | 165 | 34871073 |
| Angioedema | 28.15 | 10.23 | 30 | 85663 | 37344 | 34833894 |
| Joint swelling | 28.08 | 10.23 | 66 | 85627 | 59824 | 34811414 |
| Drug intolerance | 27.65 | 10.23 | 66 | 85627 | 59504 | 34811734 |
| Prescription form tampering | 27.38 | 10.23 | 16 | 85677 | 450 | 34870788 |
| Intentional product use issue | 27.19 | 10.23 | 67 | 85626 | 59749 | 34811489 |
| Febrile neutropenia | 27.19 | 10.23 | 210 | 85483 | 136639 | 34734599 |
| Drug tolerance | 26.49 | 10.23 | 34 | 85659 | 2848 | 34868390 |
| Drug detoxification | 26.15 | 10.23 | 13 | 85680 | 262 | 34870976 |
| Logorrhoea | 26.13 | 10.23 | 31 | 85662 | 2395 | 34868843 |
| Condition aggravated | 25.96 | 10.23 | 324 | 85369 | 191872 | 34679366 |
| General physical health deterioration | 25.40 | 10.23 | 197 | 85496 | 128072 | 34743166 |
| Drug diversion | 24.52 | 10.23 | 19 | 85674 | 860 | 34870378 |
| Incoherent | 24.19 | 10.23 | 41 | 85652 | 4411 | 34866827 |
| Altered state of consciousness | 23.65 | 10.23 | 115 | 85578 | 22778 | 34848460 |
| Anger | 23.20 | 10.23 | 73 | 85620 | 11811 | 34859427 |
| Circadian rhythm sleep disorder | 22.42 | 10.23 | 14 | 85679 | 445 | 34870793 |
| Nervousness | 22.41 | 10.23 | 75 | 85618 | 12531 | 34858707 |
| Tachyphrenia | 22.22 | 10.23 | 21 | 85672 | 1248 | 34869990 |
| Abnormal dreams | 22.21 | 10.23 | 54 | 85639 | 7524 | 34863714 |
| Hallucination, visual | 21.82 | 10.23 | 94 | 85599 | 17697 | 34853541 |
| Sleep apnoea syndrome | 21.65 | 10.23 | 103 | 85590 | 20218 | 34851020 |
| Septic shock | 21.29 | 10.23 | 97 | 85596 | 71737 | 34799501 |
| Neutropenia | 21.27 | 10.23 | 264 | 85429 | 156514 | 34714724 |
| Poor quality sleep | 21.24 | 10.23 | 56 | 85637 | 8200 | 34863038 |
| Drug screen positive | 21.01 | 10.23 | 36 | 85657 | 3907 | 34867331 |
| Reduced facial expression | 20.93 | 10.23 | 19 | 85674 | 1072 | 34870166 |
| Bradypnoea | 20.88 | 10.23 | 30 | 85663 | 2799 | 34868439 |
| Infection | 20.74 | 10.23 | 134 | 85559 | 90781 | 34780457 |
| Irritability | 20.01 | 10.23 | 116 | 85577 | 24574 | 34846664 |
| Rectal haemorrhage | 19.97 | 10.23 | 43 | 85650 | 40206 | 34831032 |
| Victim of chemical submission | 19.96 | 10.23 | 7 | 85686 | 55 | 34871183 |
| Substance use disorder | 19.92 | 10.23 | 16 | 85677 | 763 | 34870475 |
| Synovitis | 19.83 | 10.23 | 5 | 85688 | 14061 | 34857177 |
| Sepsis | 19.51 | 10.23 | 289 | 85404 | 166272 | 34704966 |
| Dyspnoea | 19.36 | 10.23 | 742 | 84951 | 376040 | 34495198 |
| Product dose omission issue | 19.22 | 10.23 | 194 | 85499 | 119517 | 34751721 |
| Self-medication | 18.98 | 10.23 | 28 | 85665 | 2675 | 34868563 |
| Product use issue | 18.95 | 10.23 | 85 | 85608 | 63131 | 34808107 |
| Distributive shock | 18.68 | 10.23 | 19 | 85674 | 1235 | 34870003 |
| Encephalomalacia | 18.57 | 10.23 | 16 | 85677 | 842 | 34870396 |
| Cardiac arrest | 18.52 | 10.23 | 335 | 85358 | 95824 | 34775414 |
| Patient elopement | 18.49 | 10.23 | 6 | 85687 | 36 | 34871202 |
| Major depression | 18.40 | 10.23 | 37 | 85656 | 4535 | 34866703 |
| Mental disorder | 18.37 | 10.23 | 80 | 85613 | 15129 | 34856109 |
| Infusion related reaction | 17.99 | 10.23 | 68 | 85625 | 52989 | 34818249 |
| Disturbance in attention | 17.93 | 10.23 | 117 | 85576 | 25828 | 34845410 |
| Drug withdrawal convulsions | 17.84 | 10.23 | 18 | 85675 | 1159 | 34870079 |
| Dysarthria | 17.81 | 10.23 | 146 | 85547 | 34636 | 34836602 |
| Treatment failure | 17.75 | 10.23 | 57 | 85636 | 46640 | 34824598 |
| Inappropriate antidiuretic hormone secretion | 17.70 | 10.23 | 70 | 85623 | 12683 | 34858555 |
| Asthma | 17.69 | 10.23 | 50 | 85643 | 42606 | 34828632 |
| Alcohol use | 17.49 | 10.23 | 30 | 85663 | 3258 | 34867980 |
| Heart rate decreased | 17.40 | 10.23 | 32 | 85661 | 31713 | 34839525 |
| Hyperlipidaemia | 17.23 | 10.23 | 76 | 85617 | 14453 | 34856785 |
| Procalcitonin abnormal | 17.04 | 10.23 | 11 | 85682 | 371 | 34870867 |
| Erythema | 16.80 | 10.23 | 138 | 85555 | 88642 | 34782596 |
| Sexual abuse | 16.56 | 10.23 | 8 | 85685 | 151 | 34871087 |
| Neurotoxicity | 16.52 | 10.23 | 12 | 85681 | 17998 | 34853240 |
| Respiratory tract infection bacterial | 16.34 | 10.23 | 21 | 85672 | 1761 | 34869477 |
| Leukopenia | 16.26 | 10.23 | 89 | 85604 | 62767 | 34808471 |
| Sleep disorder | 16.22 | 10.23 | 133 | 85560 | 31555 | 34839683 |
| Feeling abnormal | 16.19 | 10.23 | 231 | 85462 | 63004 | 34808234 |
| Vascular dementia | 15.96 | 10.23 | 12 | 85681 | 519 | 34870719 |
| Sleep talking | 15.74 | 10.23 | 12 | 85681 | 530 | 34870708 |
| Amimia | 15.68 | 10.23 | 4 | 85689 | 8 | 34871230 |
| Pre-existing condition improved | 15.60 | 10.23 | 25 | 85668 | 2567 | 34868671 |
| Mania | 15.52 | 10.23 | 55 | 85638 | 9456 | 34861782 |
| Apallic syndrome | 15.47 | 10.23 | 9 | 85684 | 251 | 34870987 |
| Personality change | 15.47 | 10.23 | 37 | 85656 | 5102 | 34866136 |
| Peripheral swelling | 15.40 | 10.23 | 117 | 85576 | 76424 | 34794814 |
| Galactorrhoea | 15.40 | 10.23 | 11 | 85682 | 439 | 34870799 |
| Product administration error | 15.40 | 10.23 | 80 | 85613 | 16264 | 34854974 |
| Product substitution issue | 15.31 | 10.23 | 57 | 85636 | 10038 | 34861200 |
| Accidental overdose | 15.27 | 10.23 | 93 | 85600 | 20047 | 34851191 |
| Coagulation factor VII level decreased | 15.21 | 10.23 | 7 | 85686 | 118 | 34871120 |
| Pneumonitis chemical | 15.06 | 10.23 | 8 | 85685 | 186 | 34871052 |
| Bronchiectasis | 14.79 | 10.23 | 3 | 85690 | 9798 | 34861440 |
| Pulmonary fibrosis | 14.73 | 10.23 | 14 | 85679 | 18382 | 34852856 |
| Tubulointerstitial nephritis | 14.61 | 10.23 | 18 | 85675 | 21006 | 34850232 |
| Cardiac failure | 14.59 | 10.23 | 148 | 85545 | 91100 | 34780138 |
| Toxic epidermal necrolysis | 14.56 | 10.23 | 19 | 85674 | 21627 | 34849611 |
| Exposure via ingestion | 14.47 | 10.23 | 22 | 85671 | 2159 | 34869079 |
| COVID-19 | 14.47 | 10.23 | 121 | 85572 | 77429 | 34793809 |
| Loss of personal independence in daily activities | 14.43 | 10.23 | 38 | 85655 | 33141 | 34838097 |
| Libido decreased | 14.34 | 10.23 | 34 | 85659 | 4662 | 34866576 |
| Labelled drug-food interaction medication error | 14.07 | 10.23 | 5 | 85688 | 41 | 34871197 |
| Mental status changes | 14.04 | 10.23 | 149 | 85544 | 37934 | 34833304 |
| Transplant rejection | 13.91 | 10.23 | 4 | 85689 | 10307 | 34860931 |
| Skin laceration | 13.76 | 10.23 | 64 | 85629 | 12445 | 34858793 |
| Substance-induced mood disorder | 13.61 | 10.23 | 6 | 85687 | 91 | 34871147 |
| Dysphoria | 13.58 | 10.23 | 22 | 85671 | 2280 | 34868958 |
| Congenital hydrocephalus | 13.55 | 10.23 | 6 | 85687 | 92 | 34871146 |
| Prostate cancer | 13.32 | 10.23 | 51 | 85642 | 39598 | 34831640 |
| Stress at work | 13.32 | 10.23 | 8 | 85685 | 237 | 34871001 |
| Depressed level of consciousness | 13.26 | 10.23 | 162 | 85531 | 42679 | 34828559 |
| Urticaria | 13.19 | 10.23 | 94 | 85599 | 62283 | 34808955 |
| Emotional distress | 13.10 | 10.23 | 72 | 85621 | 14954 | 34856284 |
| Mental impairment | 13.01 | 10.23 | 55 | 85638 | 10267 | 34860971 |
| Pruritus | 12.86 | 10.23 | 258 | 85435 | 141723 | 34729515 |
| Aspergillus infection | 12.85 | 10.23 | 7 | 85686 | 12247 | 34858991 |
| Thrombotic microangiopathy | 12.81 | 10.23 | 5 | 85688 | 10625 | 34860613 |
| Hepatitis C virus test positive | 12.81 | 10.23 | 9 | 85684 | 350 | 34870888 |
| Bipolar disorder | 12.79 | 10.23 | 28 | 85665 | 3641 | 34867597 |
| Mucosal inflammation | 12.77 | 10.23 | 50 | 85643 | 38572 | 34832666 |
| Paranoia | 12.73 | 10.23 | 61 | 85632 | 12007 | 34859231 |
| Implant site inflammation | 12.73 | 10.23 | 6 | 85687 | 107 | 34871131 |
| Delusion | 12.71 | 10.23 | 63 | 85630 | 12572 | 34858666 |
| Stress cardiomyopathy | 12.59 | 10.23 | 20 | 85673 | 2039 | 34869199 |
| Blood pressure fluctuation | 12.50 | 10.23 | 27 | 85666 | 25222 | 34846016 |
| Therapy partial responder | 12.48 | 10.23 | 4 | 85689 | 9612 | 34861626 |
| Hospitalisation | 12.40 | 10.23 | 85 | 85608 | 56817 | 34814421 |
| Pyrexia | 12.37 | 10.23 | 679 | 85014 | 332334 | 34538904 |
| Slow speech | 12.36 | 10.23 | 15 | 85678 | 1187 | 34870051 |
| Respiratory tract infection viral | 12.14 | 10.23 | 22 | 85671 | 2495 | 34868743 |
| Victim of homicide | 11.93 | 10.23 | 6 | 85687 | 124 | 34871114 |
| Pilonidal cyst congenital | 11.93 | 10.23 | 4 | 85689 | 27 | 34871211 |
| Psychomotor hyperactivity | 11.92 | 10.23 | 51 | 85642 | 9571 | 34861667 |
| Enuresis | 11.91 | 10.23 | 21 | 85672 | 2332 | 34868906 |
| Electrocardiogram QT prolonged | 11.88 | 10.23 | 153 | 85540 | 40799 | 34830439 |
| Crime | 11.83 | 10.23 | 5 | 85688 | 68 | 34871170 |
| Blood pressure systolic increased | 11.82 | 10.23 | 24 | 85669 | 22928 | 34848310 |
| Hallucination, auditory | 11.69 | 10.23 | 59 | 85634 | 11858 | 34859380 |
| Akathisia | 11.65 | 10.23 | 45 | 85648 | 8064 | 34863174 |
| Depressed mood | 11.51 | 10.23 | 84 | 85609 | 19233 | 34852005 |
| Staring | 11.46 | 10.23 | 16 | 85677 | 1454 | 34869784 |
| Miosis | 11.40 | 10.23 | 50 | 85643 | 9485 | 34861753 |
| Renal impairment | 11.40 | 10.23 | 163 | 85530 | 94350 | 34776888 |
| Scar pain | 11.39 | 10.23 | 5 | 85688 | 75 | 34871163 |
| Euphoric mood | 11.33 | 10.23 | 35 | 85658 | 5606 | 34865632 |
| Labile hypertension | 11.16 | 10.23 | 5 | 85688 | 79 | 34871159 |
| Psychotic disorder | 11.13 | 10.23 | 100 | 85593 | 24352 | 34846886 |
| Obstructive airways disorder | 11.05 | 10.23 | 13 | 85680 | 15481 | 34855757 |
| Alcohol interaction | 11.04 | 10.23 | 23 | 85670 | 2890 | 34868348 |
| Blood pressure increased | 10.96 | 10.23 | 151 | 85542 | 87951 | 34783287 |
| Alcohol poisoning | 10.95 | 10.23 | 26 | 85667 | 3567 | 34867671 |
| Haematocrit decreased | 10.93 | 10.23 | 124 | 85569 | 32092 | 34839146 |
| Drug half-life reduced | 10.90 | 10.23 | 3 | 85690 | 9 | 34871229 |
| Amnestic disorder | 10.64 | 10.23 | 7 | 85686 | 244 | 34870994 |
| Hangover | 10.62 | 10.23 | 13 | 85680 | 1038 | 34870200 |
| Hepatotoxicity | 10.62 | 10.23 | 23 | 85670 | 21462 | 34849776 |
| Decreased interest | 10.60 | 10.23 | 20 | 85673 | 2340 | 34868898 |
| PO2 decreased | 10.56 | 10.23 | 16 | 85677 | 1565 | 34869673 |
| Anaphylactic reaction | 10.56 | 10.23 | 42 | 85651 | 32259 | 34838979 |
| Drug tolerance increased | 10.55 | 10.23 | 9 | 85684 | 467 | 34870771 |
| Pneumothorax traumatic | 10.47 | 10.23 | 5 | 85688 | 92 | 34871146 |
| Leukoplakia | 10.45 | 10.23 | 3 | 85690 | 11 | 34871227 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 1530.46 | 9.59 | 2333 | 182911 | 243434 | 79315710 |
| Drug abuse | 814.10 | 9.59 | 1400 | 183844 | 161291 | 79397853 |
| Drug dependence | 807.96 | 9.59 | 706 | 184538 | 40063 | 79519081 |
| Intentional overdose | 745.93 | 9.59 | 1067 | 184177 | 104893 | 79454251 |
| Somnambulism | 702.04 | 9.59 | 317 | 184927 | 5404 | 79553740 |
| Suicide attempt | 545.54 | 9.59 | 809 | 184435 | 82123 | 79477021 |
| Sopor | 425.15 | 9.59 | 451 | 184793 | 32559 | 79526585 |
| Off label use | 390.66 | 9.59 | 967 | 184277 | 906248 | 78652896 |
| Amnesia | 386.02 | 9.59 | 595 | 184649 | 62462 | 79496682 |
| Intentional self-injury | 313.87 | 9.59 | 382 | 184862 | 32037 | 79527107 |
| Overdose | 295.76 | 9.59 | 1021 | 184223 | 183185 | 79375959 |
| Synovitis | 294.64 | 9.59 | 13 | 185231 | 150721 | 79408423 |
| Drug ineffective | 287.10 | 9.59 | 1416 | 183828 | 1079497 | 78479647 |
| Drug intolerance | 285.58 | 9.59 | 128 | 185116 | 263991 | 79295153 |
| Poisoning | 284.94 | 9.59 | 322 | 184922 | 24950 | 79534194 |
| Anxiety | 266.05 | 9.59 | 1213 | 184031 | 247299 | 79311845 |
| Toxicity to various agents | 262.30 | 9.59 | 1776 | 183468 | 419764 | 79139380 |
| Abnormal sleep-related event | 255.58 | 9.59 | 91 | 185153 | 798 | 79558346 |
| Drug withdrawal syndrome | 253.45 | 9.59 | 356 | 184888 | 34362 | 79524782 |
| Respiratory arrest | 252.38 | 9.59 | 468 | 184776 | 57082 | 79502062 |
| Contraindicated product administered | 251.47 | 9.59 | 34 | 185210 | 157504 | 79401640 |
| Intentional product misuse | 251.29 | 9.59 | 630 | 184614 | 94535 | 79464609 |
| Joint swelling | 250.52 | 9.59 | 183 | 185061 | 288463 | 79270681 |
| Somnolence | 239.99 | 9.59 | 1145 | 184099 | 237836 | 79321308 |
| Poisoning deliberate | 224.45 | 9.59 | 247 | 184997 | 18581 | 79540563 |
| Depression | 218.58 | 9.59 | 1040 | 184204 | 215750 | 79343394 |
| Hand deformity | 209.77 | 9.59 | 7 | 185237 | 103912 | 79455232 |
| Infusion related reaction | 200.99 | 9.59 | 145 | 185099 | 230092 | 79329052 |
| Delirium | 193.52 | 9.59 | 531 | 184713 | 84096 | 79475048 |
| Treatment failure | 193.21 | 9.59 | 77 | 185167 | 170409 | 79388735 |
| Coma | 192.13 | 9.59 | 592 | 184652 | 100057 | 79459087 |
| Cardio-respiratory arrest | 185.96 | 9.59 | 615 | 184629 | 107895 | 79451249 |
| Suicidal ideation | 185.62 | 9.59 | 490 | 184754 | 75850 | 79483294 |
| Drug use disorder | 181.80 | 9.59 | 155 | 185089 | 8496 | 79550648 |
| Lower respiratory tract infection | 171.86 | 9.59 | 44 | 185200 | 129176 | 79429968 |
| Systemic lupus erythematosus | 167.50 | 9.59 | 38 | 185206 | 121111 | 79438033 |
| Fall | 159.76 | 9.59 | 1783 | 183461 | 485846 | 79073298 |
| Arthropathy | 156.56 | 9.59 | 110 | 185134 | 177001 | 79382143 |
| Rheumatoid arthritis | 150.72 | 9.59 | 157 | 185087 | 208313 | 79350831 |
| Disorientation | 149.62 | 9.59 | 400 | 184844 | 62376 | 79496768 |
| Peripheral swelling | 148.95 | 9.59 | 248 | 184996 | 269369 | 79289775 |
| Pericarditis | 143.49 | 9.59 | 33 | 185211 | 104203 | 79454941 |
| Confusional state | 141.15 | 9.59 | 1239 | 184005 | 316758 | 79242386 |
| Abnormal behaviour | 141.01 | 9.59 | 281 | 184963 | 36140 | 79523004 |
| Sleep-related eating disorder | 139.24 | 9.59 | 55 | 185189 | 659 | 79558485 |
| Bradyphrenia | 138.07 | 9.59 | 146 | 185098 | 10494 | 79548650 |
| Maternal exposure during pregnancy | 135.64 | 9.59 | 74 | 185170 | 136464 | 79422680 |
| Duodenal ulcer perforation | 135.27 | 9.59 | 4 | 185240 | 66207 | 79492937 |
| Hypersensitivity | 133.32 | 9.59 | 254 | 184990 | 261985 | 79297159 |
| Glossodynia | 130.28 | 9.59 | 39 | 185205 | 103298 | 79455846 |
| Helicobacter infection | 124.14 | 9.59 | 10 | 185234 | 69694 | 79489450 |
| Loss of consciousness | 119.73 | 9.59 | 733 | 184511 | 167210 | 79391934 |
| Road traffic accident | 116.17 | 9.59 | 290 | 184954 | 43374 | 79515770 |
| Insomnia | 114.88 | 9.59 | 967 | 184277 | 244203 | 79314941 |
| Withdrawal syndrome | 113.48 | 9.59 | 215 | 185029 | 26639 | 79532505 |
| Wound | 111.04 | 9.59 | 66 | 185178 | 116113 | 79443031 |
| Restlessness | 110.53 | 9.59 | 296 | 184948 | 46196 | 79512948 |
| Affect lability | 106.25 | 9.59 | 131 | 185113 | 11128 | 79548016 |
| Product use in unapproved indication | 106.21 | 9.59 | 268 | 184976 | 250091 | 79309053 |
| Infection | 105.47 | 9.59 | 255 | 184989 | 241457 | 79317687 |
| Agitation | 105.22 | 9.59 | 485 | 184759 | 99230 | 79459914 |
| Drug abuser | 104.97 | 9.59 | 97 | 185147 | 5916 | 79553228 |
| Arthralgia | 102.63 | 9.59 | 843 | 184401 | 570960 | 78988184 |
| Hepatic enzyme increased | 99.84 | 9.59 | 169 | 185075 | 182441 | 79376703 |
| Alopecia | 98.64 | 9.59 | 247 | 184997 | 231108 | 79328036 |
| Swelling | 96.62 | 9.59 | 226 | 185018 | 216485 | 79342659 |
| Hallucination | 94.90 | 9.59 | 423 | 184821 | 85322 | 79473822 |
| Musculoskeletal stiffness | 93.82 | 9.59 | 164 | 185080 | 174844 | 79384300 |
| Intentional product use issue | 92.50 | 9.59 | 131 | 185113 | 151981 | 79407163 |
| Homicide | 91.93 | 9.59 | 48 | 185196 | 1138 | 79558006 |
| Therapeutic product effect incomplete | 90.15 | 9.59 | 118 | 185126 | 141527 | 79417617 |
| Folliculitis | 85.89 | 9.59 | 13 | 185231 | 55367 | 79503777 |
| Abdominal discomfort | 84.96 | 9.59 | 298 | 184946 | 250429 | 79308715 |
| Rash | 82.66 | 9.59 | 902 | 184342 | 577456 | 78981688 |
| Product use issue | 82.62 | 9.59 | 233 | 185011 | 209589 | 79349555 |
| Cardiac arrest | 80.67 | 9.59 | 679 | 184565 | 171417 | 79387727 |
| Impaired driving ability | 80.59 | 9.59 | 80 | 185164 | 5335 | 79553809 |
| Therapeutic product effect decreased | 78.69 | 9.59 | 164 | 185080 | 163699 | 79395445 |
| Drug detoxification | 78.44 | 9.59 | 31 | 185213 | 372 | 79558772 |
| Dependence | 78.32 | 9.59 | 56 | 185188 | 2366 | 79556778 |
| Sleep disorder due to general medical condition, insomnia type | 78.25 | 9.59 | 6 | 185238 | 43550 | 79515594 |
| Automatism | 76.23 | 9.59 | 25 | 185219 | 166 | 79558978 |
| Dissociative disorder | 74.63 | 9.59 | 37 | 185207 | 784 | 79558360 |
| Blister | 74.53 | 9.59 | 101 | 185143 | 119375 | 79439769 |
| Condition aggravated | 73.80 | 9.59 | 776 | 184468 | 500348 | 79058796 |
| Drug hypersensitivity | 71.26 | 9.59 | 405 | 184839 | 298511 | 79260633 |
| Dysarthria | 69.18 | 9.59 | 326 | 184918 | 67296 | 79491848 |
| Muscle injury | 67.57 | 9.59 | 15 | 185229 | 48546 | 79510598 |
| Carotid artery thrombosis | 66.82 | 9.59 | 56 | 185188 | 2997 | 79556147 |
| Mental status changes | 66.46 | 9.59 | 320 | 184924 | 66639 | 79492505 |
| Personality disorder | 65.37 | 9.59 | 76 | 185168 | 6070 | 79553074 |
| Altered state of consciousness | 65.13 | 9.59 | 237 | 185007 | 43585 | 79515559 |
| Nasopharyngitis | 64.34 | 9.59 | 337 | 184907 | 253544 | 79305600 |
| Neurologic neglect syndrome | 62.96 | 9.59 | 53 | 185191 | 2854 | 79556290 |
| Parasomnia | 62.28 | 9.59 | 29 | 185215 | 532 | 79558612 |
| Drug withdrawal convulsions | 62.02 | 9.59 | 47 | 185197 | 2173 | 79556971 |
| Blood pressure fluctuation | 61.58 | 9.59 | 40 | 185204 | 67105 | 79492039 |
| Initial insomnia | 61.12 | 9.59 | 78 | 185166 | 6860 | 79552284 |
| Mental disorder | 59.57 | 9.59 | 184 | 185060 | 31118 | 79528026 |
| Miosis | 58.94 | 9.59 | 120 | 185124 | 15669 | 79543475 |
| Disturbance in attention | 58.77 | 9.59 | 254 | 184990 | 50547 | 79508597 |
| Discomfort | 57.58 | 9.59 | 129 | 185115 | 125488 | 79433656 |
| Bradypnoea | 56.44 | 9.59 | 70 | 185174 | 5982 | 79553162 |
| Tremor | 55.96 | 9.59 | 623 | 184621 | 169460 | 79389684 |
| Adjustment disorder | 53.89 | 9.59 | 56 | 185188 | 3944 | 79555200 |
| Hallucination, visual | 53.80 | 9.59 | 183 | 185061 | 32546 | 79526598 |
| Exposure via ingestion | 53.39 | 9.59 | 63 | 185181 | 5111 | 79554033 |
| Incoherent | 53.36 | 9.59 | 77 | 185167 | 7615 | 79551529 |
| Immobilisation prolonged | 53.30 | 9.59 | 17 | 185227 | 102 | 79559042 |
| Psoriatic arthropathy | 52.74 | 9.59 | 62 | 185182 | 77937 | 79481207 |
| Red blood cell sedimentation rate increased | 51.60 | 9.59 | 21 | 185223 | 45921 | 79513223 |
| Psychomotor skills impaired | 51.14 | 9.59 | 62 | 185182 | 5175 | 79553969 |
| Mydriasis | 51.00 | 9.59 | 121 | 185123 | 17522 | 79541622 |
| Aggression | 50.91 | 9.59 | 244 | 185000 | 50714 | 79508430 |
| Wheezing | 50.90 | 9.59 | 123 | 185121 | 116541 | 79442603 |
| Parkinsonism | 48.22 | 9.59 | 114 | 185130 | 16470 | 79542674 |
| Logorrhoea | 48.14 | 9.59 | 55 | 185189 | 4310 | 79554834 |
| Neutropenia | 47.98 | 9.59 | 432 | 184812 | 287278 | 79271866 |
| Depressed level of consciousness | 46.67 | 9.59 | 384 | 184860 | 96268 | 79462876 |
| Akathisia | 46.24 | 9.59 | 98 | 185146 | 13161 | 79545983 |
| Myelosuppression | 45.95 | 9.59 | 18 | 185226 | 40278 | 79518866 |
| Panic attack | 44.84 | 9.59 | 141 | 185103 | 24075 | 79535069 |
| Gun shot wound | 44.76 | 9.59 | 30 | 185214 | 1140 | 79558004 |
| Impaired healing | 44.40 | 9.59 | 85 | 185159 | 87570 | 79471574 |
| Sleep talking | 44.10 | 9.59 | 29 | 185215 | 1067 | 79558077 |
| Emotional distress | 44.07 | 9.59 | 197 | 185047 | 39772 | 79519372 |
| Hypokinesia | 43.94 | 9.59 | 120 | 185124 | 18940 | 79540204 |
| Urticaria | 43.52 | 9.59 | 252 | 184992 | 184949 | 79374195 |
| Gastrointestinal disorder | 42.88 | 9.59 | 143 | 185101 | 122062 | 79437082 |
| Ill-defined disorder | 42.81 | 9.59 | 54 | 185190 | 65821 | 79493323 |
| Blood pressure systolic increased | 42.40 | 9.59 | 56 | 185188 | 66930 | 79492214 |
| General physical health deterioration | 41.75 | 9.59 | 423 | 184821 | 274815 | 79284329 |
| Cytomegalovirus infection | 41.05 | 9.59 | 24 | 185220 | 42620 | 79516524 |
| Self-medication | 41.02 | 9.59 | 55 | 185189 | 5077 | 79554067 |
| Angioedema | 40.95 | 9.59 | 71 | 185173 | 75964 | 79483180 |
| Exposure during pregnancy | 40.00 | 9.59 | 112 | 185132 | 101020 | 79458124 |
| Anterograde amnesia | 39.84 | 9.59 | 23 | 185221 | 668 | 79558476 |
| Reduced facial expression | 39.59 | 9.59 | 40 | 185204 | 2725 | 79556419 |
| Substance abuse | 39.29 | 9.59 | 80 | 185164 | 10446 | 79548698 |
| Euphoric mood | 39.21 | 9.59 | 67 | 185177 | 7659 | 79551485 |
| Dyspnoea | 38.97 | 9.59 | 1612 | 183632 | 855413 | 78703731 |
| Rhabdomyolysis | 38.23 | 9.59 | 387 | 184857 | 102744 | 79456400 |
| Memory impairment | 37.52 | 9.59 | 411 | 184833 | 111323 | 79447821 |
| C-reactive protein increased | 37.49 | 9.59 | 163 | 185081 | 128864 | 79430280 |
| Bradykinesia | 37.25 | 9.59 | 67 | 185177 | 7976 | 79551168 |
| Motor dysfunction | 37.25 | 9.59 | 96 | 185148 | 14637 | 79544507 |
| Major depression | 36.83 | 9.59 | 71 | 185173 | 8909 | 79550235 |
| Nightmare | 36.03 | 9.59 | 137 | 185107 | 25724 | 79533420 |
| Legal problem | 35.73 | 9.59 | 14 | 185230 | 164 | 79558980 |
| High risk sexual behaviour | 35.47 | 9.59 | 7 | 185237 | 0 | 79559144 |
| Irritability | 35.46 | 9.59 | 189 | 185055 | 40955 | 79518189 |
| Drug screen positive | 35.39 | 9.59 | 56 | 185188 | 6007 | 79553137 |
| Listless | 34.95 | 9.59 | 44 | 185200 | 3817 | 79555327 |
| Psychomotor hyperactivity | 34.85 | 9.59 | 102 | 185142 | 16747 | 79542397 |
| Hallucination, auditory | 34.27 | 9.59 | 116 | 185128 | 20577 | 79538567 |
| Head injury | 33.82 | 9.59 | 174 | 185070 | 37195 | 79521949 |
| COVID-19 | 33.68 | 9.59 | 221 | 185023 | 157453 | 79401691 |
| Inflammation | 33.37 | 9.59 | 109 | 185135 | 93644 | 79465500 |
| Alcohol use | 32.98 | 9.59 | 48 | 185196 | 4783 | 79554361 |
| Analgesic drug level above therapeutic | 32.87 | 9.59 | 18 | 185226 | 471 | 79558673 |
| Anger | 32.76 | 9.59 | 101 | 185143 | 17061 | 79542083 |
| Drug tolerance | 32.46 | 9.59 | 66 | 185178 | 8609 | 79550535 |
| Behaviour disorder | 32.37 | 9.59 | 55 | 185189 | 6258 | 79552886 |
| Anaphylactic reaction | 32.19 | 9.59 | 94 | 185150 | 83649 | 79475495 |
| Coordination abnormal | 31.32 | 9.59 | 100 | 185144 | 17212 | 79541932 |
| Liver injury | 31.28 | 9.59 | 52 | 185192 | 56562 | 79502582 |
| Pruritus | 31.12 | 9.59 | 689 | 184555 | 393959 | 79165185 |
| Hyponatraemia | 31.01 | 9.59 | 583 | 184661 | 177265 | 79381879 |
| Inappropriate antidiuretic hormone secretion | 30.76 | 9.59 | 132 | 185112 | 26181 | 79532963 |
| Pulmonary fibrosis | 29.89 | 9.59 | 35 | 185209 | 44077 | 79515067 |
| Obstructive airways disorder | 29.87 | 9.59 | 18 | 185226 | 31441 | 79527703 |
| Dysphagia | 29.71 | 9.59 | 423 | 184821 | 121713 | 79437431 |
| Multiple organ dysfunction syndrome | 29.66 | 9.59 | 161 | 185083 | 120085 | 79439059 |
| Persistent genital arousal disorder | 29.57 | 9.59 | 14 | 185230 | 267 | 79558877 |
| Asthma | 29.54 | 9.59 | 188 | 185056 | 134907 | 79424237 |
| Septic shock | 29.43 | 9.59 | 166 | 185078 | 122635 | 79436509 |
| Blood pressure systolic abnormal | 29.29 | 9.59 | 3 | 185241 | 17244 | 79541900 |
| Hip arthroplasty | 29.27 | 9.59 | 24 | 185220 | 35732 | 79523412 |
| Apathy | 29.21 | 9.59 | 81 | 185163 | 12896 | 79546248 |
| Acute kidney injury | 29.15 | 9.59 | 952 | 184292 | 518452 | 79040692 |
| Urinary retention | 28.97 | 9.59 | 228 | 185016 | 56402 | 79502742 |
| Mobility decreased | 28.82 | 9.59 | 166 | 185078 | 122009 | 79437135 |
| Product substitution issue | 28.79 | 9.59 | 108 | 185136 | 20148 | 79538996 |
| Abnormal dreams | 28.48 | 9.59 | 74 | 185170 | 11338 | 79547806 |
| Heart rate decreased | 28.46 | 9.59 | 77 | 185167 | 70239 | 79488905 |
| Erythema | 27.66 | 9.59 | 359 | 184885 | 222931 | 79336213 |
| Premature delivery | 27.56 | 9.59 | 10 | 185234 | 23457 | 79535687 |
| Mania | 27.34 | 9.59 | 99 | 185145 | 18161 | 79540983 |
| Sensory loss | 27.21 | 9.59 | 79 | 185165 | 12912 | 79546232 |
| Skin haemorrhage | 27.19 | 9.59 | 75 | 185169 | 11906 | 79547238 |
| Unresponsive to stimuli | 27.11 | 9.59 | 222 | 185022 | 55566 | 79503578 |
| Multiple sclerosis relapse | 26.99 | 9.59 | 193 | 185051 | 46340 | 79512804 |
| Hyperlipidaemia | 26.83 | 9.59 | 126 | 185118 | 25967 | 79533177 |
| Eating disorder | 26.69 | 9.59 | 107 | 185137 | 20590 | 79538554 |
| Labelled drug-food interaction issue | 26.63 | 9.59 | 8 | 185236 | 38 | 79559106 |
| Substance use disorder | 26.52 | 9.59 | 20 | 185224 | 918 | 79558226 |
| Stomatitis | 25.93 | 9.59 | 217 | 185027 | 146540 | 79412604 |
| Bone erosion | 25.89 | 9.59 | 5 | 185239 | 17842 | 79541302 |
| Muscle rigidity | 25.81 | 9.59 | 103 | 185141 | 19779 | 79539365 |
| Live birth | 25.65 | 9.59 | 6 | 185238 | 18738 | 79540406 |
| Imprisonment | 25.38 | 9.59 | 16 | 185228 | 547 | 79558597 |
| Dysphoria | 25.28 | 9.59 | 42 | 185202 | 4692 | 79554452 |
| Electrocardiogram QT prolonged | 25.26 | 9.59 | 321 | 184923 | 90065 | 79469079 |
| Cough | 25.15 | 9.59 | 654 | 184590 | 366135 | 79193009 |
| Blood pressure diastolic decreased | 25.09 | 9.59 | 20 | 185224 | 30196 | 79528948 |
| Antidepressant drug level above therapeutic | 25.06 | 9.59 | 17 | 185227 | 659 | 79558485 |
| Tension | 24.77 | 9.59 | 40 | 185204 | 4364 | 79554780 |
| Thinking abnormal | 24.70 | 9.59 | 77 | 185167 | 13084 | 79546060 |
| Laryngeal pain | 24.66 | 9.59 | 48 | 185196 | 6066 | 79553078 |
| Toxic epidermal necrolysis | 24.58 | 9.59 | 41 | 185203 | 44540 | 79514604 |
| Grip strength decreased | 24.55 | 9.59 | 10 | 185234 | 21859 | 79537285 |
| Adverse drug reaction | 24.46 | 9.59 | 76 | 185168 | 66316 | 79492828 |
| Mucosal inflammation | 24.13 | 9.59 | 92 | 185152 | 75488 | 79483656 |
| Neurotoxicity | 24.03 | 9.59 | 24 | 185220 | 32494 | 79526650 |
| Irritable bowel syndrome | 23.82 | 9.59 | 70 | 185174 | 62171 | 79496973 |
| Drug tolerance increased | 23.57 | 9.59 | 16 | 185228 | 621 | 79558523 |
| Pyrexia | 23.39 | 9.59 | 1314 | 183930 | 677395 | 78881749 |
| Hemiplegia | 23.22 | 9.59 | 82 | 185162 | 14857 | 79544287 |
| Deep vein thrombosis | 23.04 | 9.59 | 402 | 184842 | 120517 | 79438627 |
| Peripheral circulatory failure | 23.00 | 9.59 | 20 | 185224 | 1126 | 79558018 |
| Joint range of motion decreased | 22.99 | 9.59 | 26 | 185218 | 33256 | 79525888 |
| Inappropriate schedule of product administration | 22.97 | 9.59 | 199 | 185045 | 133429 | 79425715 |
| Accidental overdose | 22.86 | 9.59 | 164 | 185080 | 39417 | 79519727 |
| Illusion | 22.78 | 9.59 | 24 | 185220 | 1717 | 79557427 |
| Nervousness | 22.62 | 9.59 | 144 | 185100 | 33271 | 79525873 |
| Therapy non-responder | 22.53 | 9.59 | 124 | 185120 | 92181 | 79466963 |
| Productive cough | 22.49 | 9.59 | 117 | 185127 | 88214 | 79470930 |
| Fear | 22.48 | 9.59 | 106 | 185138 | 21880 | 79537264 |
| Psychotic disorder | 22.46 | 9.59 | 169 | 185075 | 41233 | 79517911 |
| Panic disorder | 22.30 | 9.59 | 31 | 185213 | 2961 | 79556183 |
| Inadequate analgesia | 22.00 | 9.59 | 39 | 185205 | 4590 | 79554554 |
| Brain contusion | 21.77 | 9.59 | 21 | 185223 | 1352 | 79557792 |
| Urinary hesitation | 21.66 | 9.59 | 37 | 185207 | 4229 | 79554915 |
| Syncope | 21.63 | 9.59 | 558 | 184686 | 178891 | 79380253 |
| Encephalomalacia | 21.62 | 9.59 | 20 | 185224 | 1221 | 79557923 |
| Multiple drug therapy | 21.54 | 9.59 | 36 | 185208 | 4042 | 79555102 |
| Drug diversion | 21.50 | 9.59 | 20 | 185224 | 1230 | 79557914 |
| Bipolar disorder | 21.35 | 9.59 | 52 | 185192 | 7655 | 79551489 |
| Pain | 21.17 | 9.59 | 1380 | 183864 | 702422 | 78856722 |
| Pathogen resistance | 20.84 | 9.59 | 4 | 185240 | 14338 | 79544806 |
| Diarrhoea | 20.82 | 9.59 | 1762 | 183482 | 878727 | 78680417 |
| Oedematous pancreatitis | 20.69 | 9.59 | 19 | 185225 | 1149 | 79557995 |
| Cholecystitis chronic | 20.52 | 9.59 | 60 | 185184 | 9846 | 79549298 |
| Aplastic anaemia | 20.41 | 9.59 | 8 | 185236 | 17897 | 79541247 |
| Sinus congestion | 20.40 | 9.59 | 96 | 185148 | 19800 | 79539344 |
| Galactorrhoea | 20.35 | 9.59 | 33 | 185211 | 3613 | 79555531 |
| Multiple sclerosis | 20.34 | 9.59 | 104 | 185140 | 22178 | 79536966 |
| Femoral neck fracture | 20.23 | 9.59 | 60 | 185184 | 9924 | 79549220 |
| Feeling drunk | 20.20 | 9.59 | 38 | 185206 | 4681 | 79554463 |
| Accidental poisoning | 20.20 | 9.59 | 22 | 185222 | 1635 | 79557509 |
| Vision blurred | 20.15 | 9.59 | 352 | 184892 | 105546 | 79453598 |
| Transplant rejection | 20.08 | 9.59 | 10 | 185234 | 19427 | 79539717 |
| Tachycardia | 20.06 | 9.59 | 548 | 184696 | 177220 | 79381924 |
| Catatonia | 20.05 | 9.59 | 55 | 185189 | 8701 | 79550443 |
| Labelled drug-drug interaction medication error | 19.76 | 9.59 | 21 | 185223 | 27629 | 79531515 |
| Stress cardiomyopathy | 19.75 | 9.59 | 64 | 185180 | 11102 | 79548042 |
| Bronchiectasis | 19.64 | 9.59 | 14 | 185230 | 22372 | 79536772 |
| Disinhibition | 19.49 | 9.59 | 27 | 185217 | 2571 | 79556573 |
| Fibromyalgia | 19.47 | 9.59 | 80 | 185164 | 64260 | 79494884 |
| Feeling abnormal | 19.18 | 9.59 | 495 | 184749 | 158704 | 79400440 |
| Victim of homicide | 19.14 | 9.59 | 9 | 185235 | 169 | 79558975 |
| Febrile neutropenia | 19.14 | 9.59 | 400 | 184844 | 230599 | 79328545 |
| Delusion | 19.11 | 9.59 | 96 | 185148 | 20327 | 79538817 |
| Prothrombin time shortened | 19.10 | 9.59 | 30 | 185214 | 3198 | 79555946 |
| Self-injurious ideation | 19.06 | 9.59 | 32 | 185212 | 3606 | 79555538 |
| Hangover | 19.01 | 9.59 | 24 | 185220 | 2088 | 79557056 |
| Victim of sexual abuse | 18.83 | 9.59 | 13 | 185231 | 519 | 79558625 |
| Drug resistance | 18.81 | 9.59 | 44 | 185200 | 42169 | 79516975 |
| Aspartate aminotransferase increased | 18.77 | 9.59 | 438 | 184806 | 138203 | 79420941 |
| Hepatotoxicity | 18.76 | 9.59 | 59 | 185185 | 51293 | 79507851 |
| Foreign body | 18.67 | 9.59 | 28 | 185216 | 2866 | 79556278 |
| Weight increased | 18.63 | 9.59 | 496 | 184748 | 276890 | 79282254 |
| Bulimia nervosa | 18.60 | 9.59 | 10 | 185234 | 252 | 79558892 |
| Immunodeficiency | 18.59 | 9.59 | 14 | 185230 | 21754 | 79537390 |
| Sinus disorder | 18.55 | 9.59 | 102 | 185142 | 22362 | 79536782 |
| Sinus tachycardia | 18.55 | 9.59 | 148 | 185096 | 36760 | 79522384 |
| Hyperhidrosis | 18.53 | 9.59 | 472 | 184772 | 151020 | 79408124 |
| Depressed mood | 18.48 | 9.59 | 183 | 185061 | 48297 | 79510847 |
| Peptic ulcer | 18.33 | 9.59 | 43 | 185201 | 6180 | 79552964 |
| Tardive dyskinesia | 18.16 | 9.59 | 60 | 185184 | 10511 | 79548633 |
| Disease progression | 18.12 | 9.59 | 310 | 184934 | 184052 | 79375092 |
| Poor quality sleep | 17.99 | 9.59 | 102 | 185142 | 22620 | 79536524 |
| Performance fear | 17.51 | 9.59 | 4 | 185240 | 4 | 79559140 |
| Muscle spasticity | 17.39 | 9.59 | 97 | 185147 | 21378 | 79537766 |
| Facial nerve disorder | 17.39 | 9.59 | 14 | 185230 | 708 | 79558436 |
| Decreased interest | 17.38 | 9.59 | 31 | 185213 | 3666 | 79555478 |
| Enthesopathy | 17.38 | 9.59 | 3 | 185241 | 11605 | 79547539 |
| Procalcitonin abnormal | 17.37 | 9.59 | 11 | 185233 | 379 | 79558765 |
| Sneezing | 17.36 | 9.59 | 91 | 185153 | 19592 | 79539552 |
| Haematocrit decreased | 17.24 | 9.59 | 218 | 185026 | 61094 | 79498050 |
| Speech disorder | 17.24 | 9.59 | 198 | 185046 | 54247 | 79504897 |
| Skin ulcer | 17.23 | 9.59 | 66 | 185178 | 54084 | 79505060 |
| Thrombotic microangiopathy | 17.19 | 9.59 | 13 | 185231 | 20156 | 79538988 |
| Post transplant lymphoproliferative disorder | 17.08 | 9.59 | 3 | 185241 | 11461 | 79547683 |
| Libido decreased | 17.04 | 9.59 | 38 | 185206 | 5283 | 79553861 |
| Device expulsion | 17.01 | 9.59 | 21 | 185223 | 25840 | 79533304 |
| Bronchopulmonary aspergillosis | 17.00 | 9.59 | 16 | 185228 | 22278 | 79536866 |
| Cardiomegaly | 16.88 | 9.59 | 112 | 185132 | 26240 | 79532904 |
| Therapeutic response decreased | 16.76 | 9.59 | 89 | 185155 | 66764 | 79492380 |
| Hiatus hernia | 16.74 | 9.59 | 102 | 185142 | 23210 | 79535934 |
| Type 2 diabetes mellitus | 16.68 | 9.59 | 72 | 185172 | 57050 | 79502094 |
| Sudden onset of sleep | 16.60 | 9.59 | 13 | 185231 | 631 | 79558513 |
| Renal impairment | 16.60 | 9.59 | 262 | 184982 | 157521 | 79401623 |
| Lethargy | 16.48 | 9.59 | 273 | 184971 | 81019 | 79478125 |
| Prescription drug used without a prescription | 16.39 | 9.59 | 32 | 185212 | 4053 | 79555091 |
| Poor venous access | 16.38 | 9.59 | 11 | 185233 | 18138 | 79541006 |
| Skin necrosis | 16.28 | 9.59 | 11 | 185233 | 18076 | 79541068 |
| Palpitations | 16.23 | 9.59 | 397 | 184847 | 126213 | 79432931 |
| Tachyphrenia | 16.18 | 9.59 | 22 | 185222 | 2058 | 79557086 |
| Anhedonia | 16.10 | 9.59 | 73 | 185171 | 14825 | 79544319 |
| Alcohol poisoning | 16.08 | 9.59 | 35 | 185209 | 4786 | 79554358 |
| Victim of chemical submission | 16.08 | 9.59 | 12 | 185232 | 542 | 79558602 |
| Hypokalaemia | 15.95 | 9.59 | 443 | 184801 | 143597 | 79415547 |
| Dehydration | 15.92 | 9.59 | 717 | 184527 | 247470 | 79311674 |
| Hepatitis B DNA increased | 15.90 | 9.59 | 14 | 185230 | 801 | 79558343 |
| Cerebral atrophy | 15.86 | 9.59 | 48 | 185196 | 8027 | 79551117 |
| Loss of personal independence in daily activities | 15.80 | 9.59 | 157 | 185087 | 102423 | 79456721 |
| Hypertensive heart disease | 15.74 | 9.59 | 32 | 185212 | 4174 | 79554970 |
| Influenza like illness | 15.73 | 9.59 | 244 | 185000 | 71463 | 79487681 |
| Cholecystectomy | 15.73 | 9.59 | 53 | 185191 | 9379 | 79549765 |
| Neurogenic bladder | 15.70 | 9.59 | 32 | 185212 | 4180 | 79554964 |
| Circadian rhythm sleep disorder | 15.62 | 9.59 | 13 | 185231 | 689 | 79558455 |
| PCO2 decreased | 15.54 | 9.59 | 27 | 185217 | 3127 | 79556017 |
| Enuresis | 15.41 | 9.59 | 27 | 185217 | 3149 | 79555995 |
| Prostate cancer | 15.37 | 9.59 | 34 | 185210 | 33234 | 79525910 |
| Depressive symptom | 15.37 | 9.59 | 41 | 185203 | 6382 | 79552762 |
| Neuroglycopenia | 15.21 | 9.59 | 11 | 185233 | 473 | 79558671 |
| Blood parathyroid hormone decreased | 15.18 | 9.59 | 3 | 185241 | 10533 | 79548611 |
| Dysuria | 15.12 | 9.59 | 183 | 185061 | 50768 | 79508376 |
| Homicidal ideation | 15.00 | 9.59 | 28 | 185216 | 3429 | 79555715 |
| Cognitive disorder | 14.98 | 9.59 | 237 | 185007 | 69689 | 79489455 |
| Suicidal behaviour | 14.98 | 9.59 | 27 | 185217 | 3220 | 79555924 |
| Knee arthroplasty | 14.89 | 9.59 | 51 | 185193 | 43197 | 79515947 |
| Prescription form tampering | 14.87 | 9.59 | 10 | 185234 | 382 | 79558762 |
| Staring | 14.85 | 9.59 | 24 | 185220 | 2621 | 79556523 |
| Perseveration | 14.76 | 9.59 | 10 | 185234 | 387 | 79558757 |
| Vertigo | 14.75 | 9.59 | 234 | 185010 | 68848 | 79490296 |
| Facet joint syndrome | 14.73 | 9.59 | 4 | 185240 | 11298 | 79547846 |
| Dementia | 14.72 | 9.59 | 103 | 185141 | 24556 | 79534588 |
| Drug ineffective for unapproved indication | 14.71 | 9.59 | 65 | 185179 | 51173 | 79507971 |
| Suspected suicide | 14.71 | 9.59 | 56 | 185188 | 10520 | 79548624 |
| Posterior reversible encephalopathy syndrome | 14.65 | 9.59 | 24 | 185220 | 26257 | 79532887 |
| Tenosynovitis | 14.62 | 9.59 | 9 | 185235 | 15545 | 79543599 |
| Stupor | 14.60 | 9.59 | 42 | 185202 | 6830 | 79552314 |
| Herpes zoster | 14.53 | 9.59 | 142 | 185102 | 92941 | 79466203 |
| Generalised tonic-clonic seizure | 14.49 | 9.59 | 161 | 185083 | 43749 | 79515395 |
| Hepatitis C virus test positive | 14.31 | 9.59 | 10 | 185234 | 407 | 79558737 |
| Bipolar I disorder | 14.31 | 9.59 | 21 | 185223 | 2108 | 79557036 |
| Eye pruritus | 14.28 | 9.59 | 16 | 185228 | 20554 | 79538590 |
| Coagulation factor VII level decreased | 14.12 | 9.59 | 8 | 185236 | 224 | 79558920 |
| Arthritis | 14.10 | 9.59 | 185 | 185059 | 114695 | 79444449 |
| Affective disorder | 14.10 | 9.59 | 47 | 185197 | 8272 | 79550872 |
| Creatinine renal clearance decreased | 14.07 | 9.59 | 14 | 185230 | 18988 | 79540156 |
| Nephropathy toxic | 14.05 | 9.59 | 16 | 185228 | 20403 | 79538741 |
| Apallic syndrome | 13.85 | 9.59 | 14 | 185230 | 954 | 79558190 |
| Therapy partial responder | 13.84 | 9.59 | 12 | 185232 | 17385 | 79541759 |
| Generalised anxiety disorder | 13.81 | 9.59 | 21 | 185223 | 2176 | 79556968 |
| Blood creatine phosphokinase increased | 13.79 | 9.59 | 223 | 185021 | 65867 | 79493277 |
| Joint effusion | 13.65 | 9.59 | 13 | 185231 | 18001 | 79541143 |
| Product dose omission issue | 13.54 | 9.59 | 455 | 184789 | 247082 | 79312062 |
| Sudden death | 13.42 | 9.59 | 94 | 185150 | 22417 | 79536727 |
| Mouth ulceration | 13.41 | 9.59 | 45 | 185199 | 38349 | 79520795 |
| Anorexia nervosa | 13.39 | 9.59 | 8 | 185236 | 248 | 79558896 |
| Colitis ulcerative | 13.35 | 9.59 | 39 | 185205 | 34703 | 79524441 |
| Blood potassium decreased | 13.34 | 9.59 | 166 | 185078 | 46346 | 79512798 |
| Diabetic ketoacidosis | 13.33 | 9.59 | 38 | 185206 | 34084 | 79525060 |
| Seizure | 13.33 | 9.59 | 551 | 184693 | 188283 | 79370861 |
| Respiratory tract infection bacterial | 13.27 | 9.59 | 20 | 185224 | 2057 | 79557087 |
| Intervertebral disc degeneration | 13.25 | 9.59 | 72 | 185172 | 15713 | 79543431 |
| Slow speech | 13.25 | 9.59 | 22 | 185222 | 2456 | 79556688 |
| Vascular dementia | 13.11 | 9.59 | 13 | 185231 | 866 | 79558278 |
| Persistent depressive disorder | 12.98 | 9.59 | 15 | 185229 | 1190 | 79557954 |
| Sciatica | 12.98 | 9.59 | 37 | 185207 | 33185 | 79525959 |
| PO2 decreased | 12.86 | 9.59 | 24 | 185220 | 2939 | 79556205 |
| Sinusitis | 12.75 | 9.59 | 351 | 184893 | 195150 | 79363994 |
| Oropharyngeal pain | 12.74 | 9.59 | 178 | 185066 | 109175 | 79449969 |
| Carotid artery stenosis | 12.70 | 9.59 | 47 | 185197 | 8711 | 79550433 |
| Epstein-Barr virus infection | 12.66 | 9.59 | 9 | 185235 | 14407 | 79544737 |
| Oesophageal carcinoma | 12.55 | 9.59 | 5 | 185239 | 11079 | 79548065 |
| Therapeutic response shortened | 12.55 | 9.59 | 11 | 185233 | 15852 | 79543292 |
| Injection site pain | 12.54 | 9.59 | 219 | 185025 | 129619 | 79429525 |
| Osteoarthritis | 12.48 | 9.59 | 136 | 185108 | 87173 | 79471971 |
| Injury | 12.46 | 9.59 | 251 | 184993 | 77245 | 79481899 |
| Substance-induced mood disorder | 12.46 | 9.59 | 6 | 185238 | 119 | 79559025 |
| Feeling of despair | 12.43 | 9.59 | 23 | 185221 | 2798 | 79556346 |
| Drug dependence, antepartum | 12.40 | 9.59 | 4 | 185240 | 25 | 79559119 |
| Secretion discharge | 12.40 | 9.59 | 10 | 185234 | 15012 | 79544132 |
| Respiratory tract congestion | 12.30 | 9.59 | 84 | 185160 | 19870 | 79539274 |
| Attention deficit hyperactivity disorder | 12.17 | 9.59 | 25 | 185219 | 3284 | 79555860 |
| Pneumonia aspiration | 12.17 | 9.59 | 221 | 185023 | 66746 | 79492398 |
| Product complaint | 11.97 | 9.59 | 62 | 185182 | 13287 | 79545857 |
| Distributive shock | 11.96 | 9.59 | 22 | 185222 | 2665 | 79556479 |
| Sedation | 11.93 | 9.59 | 178 | 185066 | 51717 | 79507427 |
| Asthenia | 11.88 | 9.59 | 1360 | 183884 | 510329 | 79048815 |
| Alanine aminotransferase abnormal | 11.82 | 9.59 | 3 | 185241 | 8864 | 79550280 |
| Eustachian tube disorder | 11.77 | 9.59 | 5 | 185239 | 73 | 79559071 |
| Bone marrow failure | 11.75 | 9.59 | 70 | 185174 | 51037 | 79508107 |
| Death | 11.70 | 9.59 | 1145 | 184099 | 565369 | 78993775 |
| Respiratory disorder | 11.65 | 9.59 | 59 | 185185 | 44797 | 79514347 |
| Foot deformity | 11.62 | 9.59 | 24 | 185220 | 24050 | 79535094 |
| Cardiotoxicity | 11.62 | 9.59 | 7 | 185237 | 12232 | 79546912 |
| Haematochezia | 11.56 | 9.59 | 139 | 185105 | 87506 | 79471638 |
| Social anxiety disorder | 11.53 | 9.59 | 10 | 185234 | 561 | 79558583 |
| Abulia | 11.50 | 9.59 | 13 | 185231 | 1007 | 79558137 |
| Peripheral ischaemia | 11.49 | 9.59 | 48 | 185196 | 9409 | 79549735 |
| Immobile | 11.47 | 9.59 | 39 | 185205 | 6934 | 79552210 |
| Atelectasis | 11.45 | 9.59 | 120 | 185124 | 32137 | 79527007 |
| Cerebrovascular accident | 11.39 | 9.59 | 455 | 184789 | 154837 | 79404307 |
| Blood cholesterol increased | 11.34 | 9.59 | 132 | 185112 | 83588 | 79475556 |
| Fatigue | 11.28 | 9.59 | 1944 | 183300 | 927783 | 78631361 |
| Blood testosterone decreased | 11.26 | 9.59 | 20 | 185224 | 2357 | 79556787 |
| Vertigo CNS origin | 11.24 | 9.59 | 4 | 185240 | 35 | 79559109 |
| Diverticulum | 11.22 | 9.59 | 66 | 185178 | 14830 | 79544314 |
| Hypoosmolar state | 11.17 | 9.59 | 8 | 185236 | 339 | 79558805 |
| Sudden cardiac death | 11.16 | 9.59 | 32 | 185212 | 5193 | 79553951 |
| Feeling hot | 11.15 | 9.59 | 87 | 185157 | 59647 | 79499497 |
| Neurological examination normal | 11.14 | 9.59 | 4 | 185240 | 36 | 79559108 |
| Coagulation factor VIII level increased | 11.14 | 9.59 | 4 | 185240 | 36 | 79559108 |
| Sputum discoloured | 11.08 | 9.59 | 21 | 185223 | 21722 | 79537422 |
| Rectocele repair | 11.06 | 9.59 | 3 | 185241 | 9 | 79559135 |
| Cytopenia | 11.00 | 9.59 | 19 | 185225 | 20364 | 79538780 |
| Respiratory depression | 10.87 | 9.59 | 105 | 185139 | 27525 | 79531619 |
| Acute graft versus host disease | 10.86 | 9.59 | 5 | 185239 | 10162 | 79548982 |
| Refusal of treatment by relative | 10.85 | 9.59 | 11 | 185233 | 752 | 79558392 |
| Leukopenia | 10.78 | 9.59 | 198 | 185046 | 116315 | 79442829 |
| Aortic valve calcification | 10.77 | 9.59 | 11 | 185233 | 759 | 79558385 |
| Amnestic disorder | 10.76 | 9.59 | 10 | 185234 | 614 | 79558530 |
| Head discomfort | 10.76 | 9.59 | 64 | 185180 | 14438 | 79544706 |
| Lip dry | 10.70 | 9.59 | 12 | 185232 | 15406 | 79543738 |
| Tubulointerstitial nephritis | 10.68 | 9.59 | 49 | 185195 | 38186 | 79520958 |
| Coagulation factor V level decreased | 10.67 | 9.59 | 10 | 185234 | 621 | 79558523 |
| Labelled drug-food interaction medication error | 10.66 | 9.59 | 6 | 185238 | 166 | 79558978 |
| COVID-19 pneumonia | 10.64 | 9.59 | 33 | 185211 | 28816 | 79530328 |
| Crohn's disease | 10.63 | 9.59 | 18 | 185226 | 2042 | 79557102 |
| Dermatitis allergic | 10.63 | 9.59 | 16 | 185228 | 18114 | 79541030 |
| Dyssomnia | 10.60 | 9.59 | 4 | 185240 | 42 | 79559102 |
| Loss of proprioception | 10.58 | 9.59 | 11 | 185233 | 775 | 79558369 |
| Pancreatic haemorrhage | 10.58 | 9.59 | 5 | 185239 | 95 | 79559049 |
| Bursitis | 10.58 | 9.59 | 45 | 185199 | 35799 | 79523345 |
| Psychomotor retardation | 10.54 | 9.59 | 35 | 185209 | 6149 | 79552995 |
| Lupus-like syndrome | 10.50 | 9.59 | 10 | 185234 | 13847 | 79545297 |
| Left ventricular dysfunction | 10.49 | 9.59 | 18 | 185226 | 19343 | 79539801 |
| Sepsis | 10.49 | 9.59 | 515 | 184729 | 268913 | 79290231 |
| Mental impairment | 10.49 | 9.59 | 78 | 185166 | 18958 | 79540186 |
| Rales | 10.47 | 9.59 | 19 | 185225 | 19982 | 79539162 |
| Autoimmune disorder | 10.40 | 9.59 | 14 | 185230 | 16598 | 79542546 |
| Mood altered | 10.34 | 9.59 | 74 | 185170 | 17773 | 79541371 |
| Diplopia | 10.28 | 9.59 | 121 | 185123 | 33345 | 79525799 |
| Aspergillus infection | 10.22 | 9.59 | 18 | 185226 | 19143 | 79540001 |
| Serotonin syndrome | 10.18 | 9.59 | 154 | 185090 | 44873 | 79514271 |
| Activation syndrome | 10.17 | 9.59 | 7 | 185237 | 278 | 79558866 |
| Product administration error | 10.16 | 9.59 | 116 | 185128 | 31730 | 79527414 |
| Mood swings | 10.14 | 9.59 | 80 | 185164 | 19800 | 79539344 |
| Blastocystis infection | 10.12 | 9.59 | 4 | 185240 | 48 | 79559096 |
| Gastric polyps | 10.08 | 9.59 | 25 | 185219 | 3722 | 79555422 |
| Ulcer | 9.88 | 9.59 | 36 | 185208 | 29936 | 79529208 |
| Coeliac artery compression syndrome | 9.87 | 9.59 | 5 | 185239 | 111 | 79559033 |
| Therapeutic product effect increased | 9.85 | 9.59 | 15 | 185229 | 1556 | 79557588 |
| Product commingling | 9.79 | 9.59 | 5 | 185239 | 113 | 79559031 |
| Vasculitis | 9.77 | 9.59 | 28 | 185216 | 25074 | 79534070 |
| Skin abrasion | 9.74 | 9.59 | 59 | 185185 | 13397 | 79545747 |
| Dental pulp disorder | 9.70 | 9.59 | 3 | 185241 | 16 | 79559128 |
| Pleurodesis | 9.70 | 9.59 | 4 | 185240 | 54 | 79559090 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05CF02 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine related drugs |
| FDA CS | M0018233 | Pyridines |
| FDA MoA | N0000000196 | GABA A Agonists |
| FDA Chemical/Ingredient | N0000007570 | Pyridines |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018755 | GABA Agonists |
| MeSH PA | D058785 | GABA-A Receptor Agonists |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D000068776 | Sleep Aids, Pharmaceutical |
| CHEBI has role | CHEBI:35488 | central nervous system depressants |
| CHEBI has role | CHEBI:35717 | hypnotics |
| CHEBI has role | CHEBI:51373 | gamma-aminobutyric acid receptor agonist |
| FDA PE | N0000175728 | Central Nervous System Depression |
| FDA EPC | N0000175759 | gamma-Aminobutyric Acid-ergic Agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Initial insomnia | indication | 59050008 | |
| Insomnia | indication | 193462001 | |
| Cognitive impairment following traumatic brain injury | off-label use | 127295002 | |
| Arousal post traumatic brain injury | off-label use | 127295002 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Hallucinations | contraindication | 7011001 | |
| Asthenia | contraindication | 13791008 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Depressive disorder | contraindication | 35489007 | |
| Aggressive behavior | contraindication | 61372001 | |
| Substance abuse | contraindication | 66214007 | |
| Sleep apnea | contraindication | 73430006 | DOID:0050847 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Sleep automatism | contraindication | 247962006 | |
| Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
| Impaired cognition | contraindication | 386806002 | |
| Memory impairment | contraindication | 386807006 | |
| Attention deficit hyperactivity disorder | contraindication | 406506008 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.73 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
| 10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
| 10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG/SPRAY | ZOLPIMIST | AYTU | N022196 | Dec. 19, 2008 | DISCN | SPRAY, METERED | ORAL | 8236285 | Aug. 7, 2032 | TREATMENT OF TRANSIENT INSOMNIA |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.16 | WOMBAT-PK | CHEMBL | |||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | ALLOSTERIC MODULATOR | Ki | 7.68 | IUPHAR | IUPHAR | |||
| GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 6.70 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-2/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.81 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-3/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.42 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 7.57 | WOMBAT-PK | CHEMBL | |||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.39 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-3 | Ion channel | Ki | 6.01 | CHEMBL | |||||
| Multidrug resistance protein 1 | Transporter | Km | 3.70 | WOMBAT-PK | |||||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | Ki | 7.30 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.12 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-5 | Ion channel | Ki | 7.46 | CHEMBL | |||||
| GABA A receptor alpha-6/beta-2/gamma-2 | Ion channel | Ki | 6.01 | CHEMBL | |||||
| GABA-A receptor; alpha-1/beta-2/gamma-2 | Ion channel | Ki | 7.72 | CHEMBL | |||||
| GABA A receptor alpha-2/beta-2/gamma-2 | Ion channel | Ki | 6.81 | CHEMBL | |||||
| CAAX prenyl protease 2 | Enzyme | AC50 | 4.77 | CHEMBL | |||||
| GABA-A receptor; anion channel | Ion channel | Ki | 7.60 | CHEMBL | |||||
| GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | Ki | 6.42 | CHEMBL | |||||
| Translocator protein | Membrane receptor | IC50 | 5.33 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00706 | KEGG_DRUG |
| 99294-93-6 | SECONDARY_CAS_RN |
| 4020811 | VANDF |
| 4023596 | VANDF |
| C0078839 | UMLSCUI |
| CHEBI:10125 | CHEBI |
| R5R | PDB_CHEM_ID |
| CHEMBL911 | ChEMBL_ID |
| CHEMBL3989820 | ChEMBL_ID |
| DB00425 | DRUGBANK_ID |
| CHEMBL1723343 | ChEMBL_ID |
| D000077334 | MESH_DESCRIPTOR_UI |
| 5732 | PUBCHEM_CID |
| 4348 | IUPHAR_LIGAND_ID |
| 5741 | INN_ID |
| 7K383OQI23 | UNII |
| 131725 | RXNORM |
| 109404 | MMSL |
| 343 | MMSL |
| 5713 | MMSL |
| d00910 | MMSL |
| 004146 | NDDF |
| 004147 | NDDF |
| 387569009 | SNOMEDCT_US |
| 395928005 | SNOMEDCT_US |
| 96231005 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5401 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 34 sections |
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5401 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 34 sections |
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5421 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 34 sections |
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5421 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5501 | TABLET, COATED | 6.25 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5501 | TABLET, COATED | 6.25 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5521 | TABLET, COATED | 12.50 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5521 | TABLET, COATED | 12.50 mg | ORAL | NDA | 34 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6010 | TABLET | 10 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6010 | TABLET | 10 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6050 | TABLET | 5 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6050 | TABLET | 5 mg | ORAL | NDA | 33 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0086 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0087 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0073 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0073 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0074 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0074 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8225 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 32 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8226 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5315 | TABLET, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5315 | TABLET, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5316 | TABLET, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5316 | TABLET, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5317 | TABLET, COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5317 | TABLET, COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5318 | TABLET, COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5318 | TABLET, COATED | 10 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6082 | TABLET | 5 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6082 | TABLET | 5 mg | ORAL | ANDA | 31 sections |