zolpidem ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
hypnotics/sedatives, zolpidem derivatives 2870 82626-48-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ambien
  • zolpidem
  • zolpidem tartrate
An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
  • Molecular weight: 307.40
  • Formula: C19H21N3O
  • CLOGP: 3.03
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 37.61
  • ALOGS: -3.99
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 23 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.47 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 72 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.54 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 1992 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 828.33 9.56 1381 138261 130508 50334974
Intentional overdose 520.15 9.56 746 138896 61758 50403724
Drug abuse 519.75 9.56 729 138913 59117 50406365
Somnambulism 494.78 9.56 251 139391 4673 50460809
Drug dependence 397.22 9.56 372 139270 19387 50446095
Amnesia 377.58 9.56 522 139120 41738 50423744
Suicide attempt 359.82 9.56 568 139074 51164 50414318
Contraindicated product administered 350.29 9.56 14 139628 148944 50316538
Drug intolerance 314.94 9.56 106 139536 218998 50246484
Synovitis 283.45 9.56 14 139628 123851 50341631
Drug ineffective 262.58 9.56 1269 138373 818064 49647418
Treatment failure 261.78 9.56 35 139607 137602 50327880
Intentional self-injury 256.93 9.56 318 139324 22794 50442688
Joint swelling 256.69 9.56 182 139460 245104 50220378
Hand deformity 251.69 9.56 5 139637 100194 50365288
Sopor 244.63 9.56 288 139354 19591 50445891
Systemic lupus erythematosus 240.14 9.56 48 139594 140574 50324908
Infusion related reaction 238.44 9.56 85 139557 169472 50296010
Anxiety 235.93 9.56 1043 138599 176563 50288919
Abnormal sleep-related event 215.25 9.56 79 139563 629 50464853
Arthropathy 204.21 9.56 90 139552 157816 50307666
Rheumatoid arthritis 201.88 9.56 158 139484 202392 50263090
Glossodynia 200.35 9.56 38 139604 115531 50349951
Overdose 198.37 9.56 666 138976 99061 50366421
Off label use 193.17 9.56 668 138974 473758 49991724
Intentional product misuse 187.71 9.56 405 139237 46329 50419153
Depression 187.69 9.56 928 138714 164495 50300987
Peripheral swelling 160.95 9.56 199 139443 205737 50259745
Alopecia 154.35 9.56 275 139367 244772 50220710
Maternal exposure during pregnancy 151.26 9.56 131 139511 159647 50305835
Toxicity to various agents 150.03 9.56 1052 138590 211447 50254035
Pericarditis 149.58 9.56 20 139622 78669 50386813
Poisoning 146.20 9.56 176 139466 12253 50453229
Wound 143.67 9.56 56 139586 105738 50359744
Somnolence 142.66 9.56 821 138821 154164 50311318
Lower respiratory tract infection 142.05 9.56 43 139599 95158 50370324
Poisoning deliberate 138.33 9.56 138 139504 7774 50457708
Hypersensitivity 137.70 9.56 239 139403 214922 50250560
Drug withdrawal syndrome 134.03 9.56 245 139397 24836 50440646
Swelling 133.26 9.56 218 139424 200654 50264828
Abdominal discomfort 126.08 9.56 283 139359 231358 50234124
Coma 124.87 9.56 393 139249 56486 50408996
Respiratory arrest 119.26 9.56 259 139383 29750 50435732
Suicidal ideation 117.31 9.56 378 139264 55007 50410475
Cardio-respiratory arrest 112.51 9.56 366 139276 53526 50411956
Fall 111.07 9.56 1411 138231 333521 50131961
Road traffic accident 104.66 9.56 217 139425 24135 50441347
Therapeutic product effect decreased 104.62 9.56 133 139509 135917 50329565
Impaired driving ability 104.42 9.56 87 139555 3874 50461608
Rash 104.34 9.56 743 138899 436728 50028754
Abnormal behaviour 102.48 9.56 190 139452 19468 50446014
Sleep-related eating disorder 100.78 9.56 47 139595 721 50464761
Infection 100.14 9.56 204 139438 172750 50292732
Product use issue 97.43 9.56 164 139478 149311 50316171
Helicobacter infection 93.58 9.56 13 139629 49689 50415793
Loss of consciousness 90.89 9.56 545 139097 103808 50361674
Arthralgia 90.62 9.56 775 138867 437927 50027555
Insomnia 86.33 9.56 798 138844 174067 50291415
Hepatic enzyme increased 84.76 9.56 156 139486 137224 50328258
Musculoskeletal stiffness 78.28 9.56 147 139495 128334 50337148
Discomfort 78.18 9.56 111 139531 108269 50357213
Drug hypersensitivity 77.25 9.56 393 139249 250617 50214865
Restlessness 75.80 9.56 195 139447 24978 50440504
Disorientation 74.96 9.56 242 139400 35242 50430240
Withdrawal syndrome 74.71 9.56 156 139486 17434 50448048
Nasopharyngitis 73.98 9.56 278 139364 192649 50272833
Mydriasis 72.87 9.56 116 139526 10511 50454971
Mental status changes 72.70 9.56 243 139399 36029 50429453
Therapeutic product effect incomplete 71.86 9.56 88 139554 91427 50374055
Folliculitis 69.88 9.56 12 139630 39213 50426269
Product substitution issue 68.48 9.56 132 139510 13925 50451557
Hallucination 67.94 9.56 282 139360 46375 50419107
Sleep disorder due to general medical condition, insomnia type 67.53 9.56 5 139637 31442 50434040
Agitation 66.57 9.56 308 139334 53076 50412406
Blister 66.16 9.56 83 139559 85335 50380147
Drug use disorder 65.91 9.56 60 139582 3012 50462470
Muscle injury 64.71 9.56 12 139630 37099 50428383
Drug abuser 62.17 9.56 56 139586 2772 50462710
Delirium 58.90 9.56 235 139407 37957 50427525
Dependence 57.52 9.56 45 139597 1830 50463652
Immobilisation prolonged 56.62 9.56 18 139624 87 50465395
Affect lability 55.99 9.56 94 139548 8904 50456578
Bradyphrenia 53.41 9.56 75 139567 6077 50459405
Product use in unapproved indication 52.53 9.56 155 139487 115664 50349818
Sleep talking 51.13 9.56 32 139610 904 50464578
Tremor 50.56 9.56 512 139130 114391 50351091
Miosis 50.49 9.56 74 139568 6236 50459246
Confusional state 50.34 9.56 756 138886 185172 50280310
Substance abuse 47.85 9.56 58 139584 4066 50461416
Cardiac arrest 47.05 9.56 393 139249 83258 50382224
Hyponatraemia 47.01 9.56 438 139204 95701 50369781
Mental disorder 46.46 9.56 150 139492 21841 50443641
Ill-defined disorder 45.65 9.56 50 139592 54604 50410878
Drug withdrawal convulsions 44.84 9.56 34 139608 1319 50464163
Exposure during pregnancy 44.03 9.56 178 139464 120837 50344645
Condition aggravated 42.85 9.56 570 139072 296488 50168994
Intentional product use issue 41.74 9.56 94 139548 76824 50388658
Listless 40.52 9.56 41 139601 2349 50463133
Urinary retention 40.26 9.56 161 139481 26029 50439453
Psychomotor skills impaired 39.82 9.56 38 139604 2026 50463456
Pain 39.11 9.56 1259 138383 577644 49887838
Parkinsonism 38.20 9.56 79 139563 8768 50456714
Altered state of consciousness 38.04 9.56 140 139502 21770 50443712
Bradypnoea 36.92 9.56 44 139598 3030 50462452
Dysarthria 36.89 9.56 202 139440 37201 50428281
Disturbance in attention 36.73 9.56 177 139465 31009 50434473
Dissociative disorder 36.61 9.56 16 139626 209 50465273
Impaired healing 36.48 9.56 87 139555 69699 50395783
Tardive dyskinesia 36.25 9.56 69 139573 7210 50458272
Depressed level of consciousness 35.84 9.56 256 139386 51697 50413785
Exposure via ingestion 35.12 9.56 41 139601 2762 50462720
Gastrointestinal disorder 34.94 9.56 138 139504 94318 50371164
Emotional distress 34.71 9.56 164 139478 28499 50436983
High risk sexual behaviour 34.27 9.56 7 139635 0 50465482
Hallucination, visual 34.03 9.56 112 139530 16470 50449012
Logorrhoea 32.52 9.56 36 139606 2288 50463194
Hip arthroplasty 32.51 9.56 22 139620 30407 50435075
Drug screen positive 31.83 9.56 43 139599 3359 50462123
Red blood cell sedimentation rate increased 31.79 9.56 21 139621 29395 50436087
Premature delivery 31.33 9.56 13 139629 23650 50441832
Initial insomnia 31.24 9.56 53 139589 5062 50460420
Panic attack 30.61 9.56 120 139522 19222 50446260
Injury 30.30 9.56 235 139407 48690 50416792
Memory impairment 29.95 9.56 343 139299 79017 50386465
Carotid artery thrombosis 29.69 9.56 28 139614 1471 50464011
Akathisia 29.30 9.56 68 139574 8161 50457321
Tachycardia 29.07 9.56 411 139231 99352 50366130
Homicide 28.97 9.56 16 139626 356 50465126
Victim of sexual abuse 28.93 9.56 18 139624 503 50464979
Drug detoxification 28.74 9.56 12 139630 139 50465343
Persistent genital arousal disorder 28.73 9.56 14 139628 238 50465244
Blood pressure fluctuation 28.58 9.56 34 139608 35789 50429693
Hallucination, auditory 28.16 9.56 79 139563 10649 50454833
Dehydration 28.02 9.56 583 139059 151866 50313616
Syncope 27.91 9.56 419 139223 102583 50362899
Cough 27.88 9.56 483 139159 240781 50224701
Bulimia nervosa 27.63 9.56 16 139626 391 50465091
Hypokalaemia 27.47 9.56 367 139275 87625 50377857
Head injury 27.33 9.56 135 139507 23885 50441597
Illusion 27.24 9.56 22 139620 937 50464545
Multiple drug therapy 27.10 9.56 30 139612 1907 50463575
Device expulsion 26.79 9.56 24 139618 28798 50436684
Urticaria 26.57 9.56 229 139413 129332 50336150
Nightmare 26.44 9.56 101 139541 15985 50449497
Pruritus 25.75 9.56 591 139051 282977 50182505
Anaphylactic reaction 25.48 9.56 71 139571 53984 50411498
Live birth 25.21 9.56 7 139635 16401 50449081
Prescription drug used without a prescription 24.95 9.56 27 139615 1673 50463809
Blood pressure systolic increased 24.86 9.56 37 139605 35412 50430070
Drug tolerance 24.57 9.56 47 139595 4929 50460553
Irritability 24.42 9.56 148 139494 28278 50437204
Adverse drug reaction 24.24 9.56 75 139567 55147 50410335
Alcohol abuse 24.14 9.56 28 139614 1873 50463609
Stomatitis 24.09 9.56 172 139470 101172 50364310
Personality disorder 24.06 9.56 43 139599 4281 50461201
Rhabdomyolysis 23.36 9.56 186 139456 38841 50426641
Neutropenia 23.12 9.56 279 139363 147686 50317796
Neurologic neglect syndrome 22.89 9.56 24 139618 1434 50464048
Drug resistance 22.72 9.56 12 139630 18977 50446505
Incoherent 22.19 9.56 41 139601 4189 50461293
Behaviour disorder 22.14 9.56 30 139612 2350 50463132
Fatigue 22.12 9.56 1668 137974 705933 49759549
Imprisonment 21.71 9.56 11 139631 204 50465278
Abnormal dreams 21.68 9.56 66 139576 9311 50456171
Hyperhidrosis 21.65 9.56 357 139285 89069 50376413
COVID-19 21.47 9.56 62 139580 46600 50418882
Cholecystitis chronic 21.38 9.56 67 139575 9602 50455880
Vertigo 21.37 9.56 228 139414 51604 50413878
Dyspnoea 21.27 9.56 1266 138376 546342 49919140
Apathy 21.22 9.56 57 139585 7491 50457991
Multiple sclerosis 21.10 9.56 112 139530 20381 50445101
Arthritis 20.70 9.56 147 139495 86574 50378908
C-reactive protein increased 20.44 9.56 104 139538 66370 50399112
Irritable bowel syndrome 20.42 9.56 73 139569 51368 50414114
Rheumatoid nodule 20.40 9.56 5 139637 12730 50452752
Hangover 20.28 9.56 22 139620 1367 50464115
Foreign body 20.12 9.56 26 139616 1945 50463537
Obstructive airways disorder 20.08 9.56 9 139633 15643 50449839
Mania 20.01 9.56 71 139571 10845 50454637
Laryngeal pain 19.92 9.56 39 139603 4160 50461322
Product complaint 19.68 9.56 73 139569 11393 50454089
Adjustment disorder 19.63 9.56 26 139616 1993 50463489
Reduced facial expression 19.45 9.56 23 139619 1571 50463911
Eating disorder 19.27 9.56 89 139553 15320 50450162
Wheezing 19.12 9.56 97 139545 61950 50403532
Diplopia 18.98 9.56 104 139538 19156 50446326
Tension 18.73 9.56 30 139612 2732 50462750
Feeling drunk 18.65 9.56 35 139607 3618 50461864
Deep vein thrombosis 18.62 9.56 295 139347 73009 50392473
Anger 18.49 9.56 71 139571 11262 50454220
Knee arthroplasty 18.48 9.56 45 139597 35801 50429681
Peptic ulcer 18.46 9.56 36 139606 3830 50461652
Panic disorder 18.42 9.56 27 139615 2276 50463206
Psychomotor hyperactivity 18.35 9.56 62 139580 9239 50456243
Sinus tachycardia 18.23 9.56 111 139531 21243 50444239
Multiple sclerosis relapse 18.19 9.56 190 139452 42774 50422708
Inflammation 18.09 9.56 88 139554 56824 50408658
Psoriatic arthropathy 17.84 9.56 68 139574 46964 50418518
Unresponsive to stimuli 17.84 9.56 145 139497 30464 50435018
Dysuria 17.69 9.56 137 139505 28367 50437115
Inadequate analgesia 17.64 9.56 28 139614 2530 50462952
Sinusitis 17.64 9.56 348 139294 170210 50295272
Death 17.51 9.56 727 138915 324652 50140830
Anterograde amnesia 17.49 9.56 13 139629 489 50464993
Major depression 17.39 9.56 50 139592 6834 50458648
Crying 17.35 9.56 106 139536 20310 50445172
Vision blurred 17.24 9.56 309 139333 78338 50387144
Dysphagia 17.14 9.56 305 139337 77213 50388269
Alcohol use 16.84 9.56 24 139618 1971 50463511
Loss of proprioception 16.73 9.56 11 139631 339 50465143
Femoral neck fracture 16.65 9.56 52 139590 7438 50458044
Mucosal inflammation 16.58 9.56 56 139586 40086 50425396
Psychotic disorder 16.53 9.56 110 139532 21702 50443780
Facial nerve disorder 16.52 9.56 13 139629 533 50464949
Aggression 16.31 9.56 107 139535 21009 50444473
Legal problem 16.29 9.56 5 139637 21 50465461
Mobility decreased 16.07 9.56 142 139500 79806 50385676
Hiatus hernia 16.07 9.56 96 139546 18248 50447234
Asthenia 15.84 9.56 1052 138590 317990 50147492
General physical health deterioration 15.84 9.56 287 139355 142147 50323335
Feeling abnormal 15.83 9.56 456 139186 125036 50340446
Decreased interest 15.80 9.56 29 139613 2947 50462535
Coagulation factor V level decreased 15.74 9.56 10 139632 290 50465192
Pulmonary vasculitis 15.71 9.56 6 139636 54 50465428
Grip strength decreased 15.50 9.56 7 139635 12114 50453368
Prothrombin time shortened 15.49 9.56 21 139621 1646 50463836
Serotonin syndrome 15.46 9.56 119 139523 24594 50440888
Liver injury 15.43 9.56 28 139614 24778 50440704
Accidental poisoning 15.41 9.56 13 139629 589 50464893
Erythema 15.36 9.56 298 139344 146116 50319366
Compulsive shopping 15.36 9.56 14 139628 704 50464778
Accidental exposure to product 15.28 9.56 25 139617 23032 50442450
Sleep terror 15.27 9.56 14 139628 709 50464773
Tracheal atresia 15.27 9.56 5 139637 27 50465455
Drug tolerance increased 15.22 9.56 9 139633 229 50465253
Thirst 15.20 9.56 64 139578 10586 50454896
Protrusion tongue 15.15 9.56 10 139632 310 50465172
Urinary hesitation 15.10 9.56 23 139619 2006 50463476
Blood potassium decreased 14.99 9.56 162 139480 36783 50428699
Renal impairment 14.94 9.56 135 139507 75526 50389956
Periventricular leukomalacia 14.73 9.56 6 139636 65 50465417
Hypotension 14.62 9.56 792 138850 234677 50230805
Cognitive disorder 14.59 9.56 186 139456 43937 50421545
Bone erosion 14.56 9.56 7 139635 11680 50453802
Herpes zoster 14.55 9.56 125 139517 70661 50394821
Brain contusion 14.48 9.56 12 139630 530 50464952
Therapy non-responder 14.48 9.56 82 139560 50940 50414542
Skin haemorrhage 14.44 9.56 47 139595 6871 50458611
Injection site reaction 14.42 9.56 80 139562 49952 50415530
Joint range of motion decreased 14.31 9.56 18 139624 18494 50446988
Panniculitis 14.30 9.56 3 139639 8500 50456982
Self-medication 14.28 9.56 24 139618 2275 50463207
Terminal insomnia 14.22 9.56 13 139629 656 50464826
Frostbite 14.07 9.56 4 139638 12 50465470
Left ventricular hypertrophy 14.04 9.56 37 139605 4808 50460674
Seizure 13.97 9.56 425 139217 117449 50348033
Sensory loss 13.90 9.56 50 139592 7688 50457794
Intravascular haemolysis 13.78 9.56 9 139633 274 50465208
Atelectasis 13.76 9.56 92 139550 18178 50447304
Pyrexia 13.67 9.56 885 138757 379318 50086164
Spinal rod insertion 13.60 9.56 4 139638 14 50465468
Self-injurious ideation 13.49 9.56 23 139619 2206 50463276
Anhedonia 13.41 9.56 57 139585 9467 50456015
Hepatotoxicity 13.40 9.56 35 139607 27191 50438291
Prothrombin time prolonged 13.32 9.56 54 139588 8784 50456698
Drug interaction 13.31 9.56 676 138966 198945 50266537
Bipolar disorder 13.30 9.56 45 139597 6712 50458770
Coordination abnormal 13.25 9.56 65 139577 11469 50454013
Neonatal behavioural syndrome 13.19 9.56 5 139637 44 50465438
Social anxiety disorder 13.12 9.56 10 139632 391 50465091
Labelled drug-food interaction issue 13.00 9.56 4 139638 17 50465465
Blastocystis infection 13.00 9.56 4 139638 17 50465465
Aortic valve calcification 12.99 9.56 10 139632 397 50465085
Dementia 12.93 9.56 82 139560 15915 50449567
Diarrhoea 12.85 9.56 1425 138217 587051 49878431
Motor dysfunction 12.85 9.56 50 139592 7981 50457501
Aspartate aminotransferase increased 12.63 9.56 293 139349 77705 50387777
Benzodiazepine drug level 12.62 9.56 3 139639 3 50465479
Constipation 12.61 9.56 630 139012 185078 50280404
Inappropriate schedule of product administration 12.57 9.56 132 139510 71699 50393783
Blood pressure systolic abnormal 12.39 9.56 3 139639 7703 50457779
Persecutory delusion 12.35 9.56 23 139619 2364 50463118
Blood pressure diastolic decreased 12.27 9.56 17 139625 16764 50448718
Type 2 diabetes mellitus 12.22 9.56 51 139591 34324 50431158
Dizziness 12.21 9.56 1112 138530 345257 50120225
Lethargy 12.20 9.56 198 139444 49234 50416248
Accidental overdose 12.19 9.56 94 139548 19439 50446043
Creatinine renal clearance decreased 12.15 9.56 9 139633 11872 50453610
Intervertebral disc degeneration 12.15 9.56 71 139571 13390 50452092
Automatism 12.13 9.56 5 139637 56 50465426
Vertigo CNS origin 12.01 9.56 4 139638 23 50465459
Psychomotor retardation 11.90 9.56 28 139614 3390 50462092
Therapeutic response unexpected 11.90 9.56 80 139562 15835 50449647
Drug dependence, antepartum 11.87 9.56 4 139638 24 50465458
Cholecystectomy 11.83 9.56 54 139588 9249 50456233
Euphoric mood 11.78 9.56 31 139611 4024 50461458
Productive cough 11.77 9.56 91 139551 52603 50412879
Inappropriate antidiuretic hormone secretion 11.65 9.56 69 139573 13074 50452408
Waxy flexibility 11.62 9.56 6 139636 116 50465366
Transplant rejection 11.60 9.56 6 139636 9603 50455879
Spleen congestion 11.53 9.56 6 139636 118 50465364
Middle insomnia 11.46 9.56 56 139586 9865 50455617
Septic shock 11.29 9.56 102 139540 57073 50408409
Influenza like illness 11.29 9.56 222 139420 57237 50408245
Respiratory depression 11.26 9.56 64 139578 11946 50453536
Spondylolisthesis 11.25 9.56 26 139616 3111 50462371
Dreamy state 11.22 9.56 4 139638 29 50465453
Enthesopathy 11.18 9.56 3 139639 7190 50458292
Multiple injuries 11.01 9.56 18 139624 1668 50463814
Angioedema 10.99 9.56 60 139582 37616 50427866
Stress cardiomyopathy 10.95 9.56 47 139595 7840 50457642
Depressive symptom 10.91 9.56 26 139616 3174 50462308
Immunodeficiency 10.87 9.56 15 139627 14813 50450669
Blood urea increased 10.79 9.56 106 139536 23479 50442003
Transient ischaemic attack 10.74 9.56 136 139506 32074 50433408
Neurotoxicity 10.71 9.56 15 139627 14725 50450757
Poor sucking reflex 10.66 9.56 7 139635 215 50465267
Neurogenic bladder 10.60 9.56 24 139618 2833 50462649
Fibrocystic breast disease 10.60 9.56 14 139628 1070 50464412
Drop attacks 10.58 9.56 11 139631 651 50464831
Trance 10.57 9.56 4 139638 35 50465447
Secretion discharge 10.57 9.56 7 139635 9784 50455698
Asphyxia 10.55 9.56 36 139606 5391 50460091
Amnestic disorder 10.54 9.56 8 139634 311 50465171
Cytomegalovirus infection 10.53 9.56 21 139621 17941 50447541
Head discomfort 10.52 9.56 59 139583 10960 50454522
Disinhibition 10.40 9.56 12 139630 798 50464684
Hepatosplenomegaly 10.40 9.56 21 139621 2291 50463191
Mouth ulceration 10.32 9.56 41 139601 27983 50437499
Toxic epidermal necrolysis 10.32 9.56 27 139615 20965 50444517
Muscle rigidity 10.31 9.56 54 139588 9775 50455707
Fear 10.21 9.56 72 139570 14477 50451005
Oophorectomy bilateral 10.19 9.56 4 139638 39 50465443
Cardiomegaly 10.10 9.56 77 139565 15868 50449614
Ecchymosis 10.08 9.56 55 139587 10114 50455368
Eustachian tube disorder 10.05 9.56 5 139637 89 50465393
Spinal osteoarthritis 10.04 9.56 70 139572 14022 50451460
Dysgeusia 10.03 9.56 157 139485 38759 50426723
Flat affect 10.00 9.56 15 139627 1290 50464192
Gun shot wound 9.91 9.56 5 139637 92 50465390
Drug withdrawal syndrome neonatal 9.85 9.56 18 139624 1823 50463659
Haemangioma of liver 9.83 9.56 13 139629 995 50464487
Lymphatic disorder 9.78 9.56 8 139634 347 50465135
Nervousness 9.76 9.56 118 139524 27533 50437949
Bone scan abnormal 9.72 9.56 8 139634 350 50465132
Sinus congestion 9.72 9.56 69 139573 13902 50451580
Cholelithiasis 9.71 9.56 153 139489 37820 50427662
Attention deficit hyperactivity disorder 9.69 9.56 21 139621 2408 50463074
Sedation 9.68 9.56 128 139514 30482 50435000
Leukocytosis 9.62 9.56 100 139542 22479 50443003
Verbal abuse 9.62 9.56 5 139637 98 50465384
Victim of chemical submission 9.59 9.56 7 139635 256 50465226
Myelosuppression 9.58 9.56 14 139628 13503 50451979
Homicidal ideation 9.57 9.56 17 139625 1685 50463797
Diabetic ketoacidosis 9.56 9.56 22 139620 17850 50447632

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Somnambulism 547.23 10.18 225 79354 2573 29492375
Completed suicide 465.15 10.18 854 78725 89392 29405556
Drug dependence 299.03 10.18 324 79255 20657 29474291
Intentional overdose 252.49 10.18 406 79173 38122 29456826
Amnesia 242.72 10.18 302 79277 22341 29472607
Drug abuse 187.13 10.18 555 79024 79328 29415620
Off label use 156.57 10.18 363 79216 300437 29194511
Road traffic accident 154.77 10.18 200 79379 15361 29479587
Suicide attempt 145.00 10.18 298 79281 33812 29461136
Intentional self-injury 125.24 10.18 161 79418 12300 29482648
Poisoning 117.96 10.18 140 79439 9853 29485095
Respiratory arrest 101.97 10.18 219 79360 25614 29469334
Drug withdrawal syndrome 98.45 10.18 175 79404 17809 29477139
Impaired driving ability 97.99 10.18 67 79512 2264 29492684
Insomnia 97.07 10.18 484 79095 88277 29406671
Sopor 89.68 10.18 128 79451 10806 29484142
Delirium 87.67 10.18 269 79310 39128 29455820
Abnormal sleep-related event 86.88 10.18 36 79543 420 29494528
Suicidal ideation 85.76 10.18 246 79333 34470 29460478
Overdose 83.57 10.18 430 79149 79389 29415559
Anxiety 79.27 10.18 445 79134 84920 29410028
Confusional state 79.24 10.18 602 78977 127275 29367673
Depression 75.87 10.18 439 79140 84708 29410240
Homicide 73.46 10.18 40 79539 888 29494060
Sleep-related eating disorder 73.41 10.18 28 79551 258 29494690
Abnormal behaviour 70.33 10.18 177 79402 22950 29471998
Product use in unapproved indication 69.21 10.18 79 79500 86796 29408152
Somnolence 69.03 10.18 461 79118 93494 29401454
Automatism 65.67 10.18 20 79559 84 29494864
Disorientation 65.15 10.18 201 79378 29314 29465634
Intentional product misuse 57.92 10.18 215 79364 34446 29460502
Gun shot wound 57.36 10.18 36 79543 1049 29493899
Drug ineffective 55.70 10.18 668 78911 362502 29132446
Parasomnia 53.44 10.18 24 79555 345 29494603
Drug abuser 49.14 10.18 56 79523 3771 29491177
Fall 42.13 10.18 690 78889 176488 29318460
Bradyphrenia 41.63 10.18 54 79525 4160 29490788
Aggression 40.35 10.18 196 79383 35345 29459603
Cardio-respiratory arrest 38.15 10.18 250 79329 50351 29444597
Restlessness 36.68 10.18 137 79442 22008 29472940
Thinking abnormal 35.38 10.18 56 79523 5180 29489768
Nightmare 35.35 10.18 88 79491 11329 29483619
Death 35.25 10.18 679 78900 341405 29153543
Memory impairment 33.06 10.18 189 79390 36281 29458667
Persistent depressive disorder 32.80 10.18 16 79563 280 29494668
Hallucination 31.95 10.18 218 79361 44494 29450454
Oedematous pancreatitis 31.83 10.18 18 79561 431 29494517
Poisoning deliberate 31.65 10.18 56 79523 5675 29489273
Coma 31.64 10.18 198 79381 39252 29455696
Agitation 31.40 10.18 241 79338 51063 29443885
Therapeutic product effect incomplete 31.00 10.18 36 79543 39269 29455679
Legal problem 30.25 10.18 13 79566 167 29494781
Rheumatoid arthritis 29.28 10.18 26 79553 32126 29462822
Lower respiratory tract infection 28.55 10.18 18 79561 26484 29468464
Drug tolerance 28.49 10.18 32 79547 2121 29492827
Dependence 28.35 10.18 23 79556 1012 29493936
Withdrawal syndrome 28.21 10.18 79 79500 10913 29484035
Dissociative disorder 28.16 10.18 13 79566 200 29494748
Toxicity to various agents 27.83 10.18 637 78942 173024 29321924
Cytomegalovirus infection 27.54 10.18 14 79565 23201 29471747
Acute kidney injury 26.82 10.18 528 79051 264739 29230209
Initial insomnia 26.54 10.18 35 79544 2740 29492208
Loss of consciousness 26.34 10.18 310 79269 73746 29421202
Septic shock 25.30 10.18 85 79494 62475 29432473
Joint swelling 24.78 10.18 61 79518 49569 29445379
Multiple organ dysfunction syndrome 24.68 10.18 87 79492 63029 29431919
Drug intolerance 24.52 10.18 59 79520 48320 29446628
Febrile neutropenia 24.51 10.18 189 79390 112051 29382897
Angioedema 24.35 10.18 30 79549 31885 29463063
Incoherent 23.92 10.18 41 79538 4051 29490897
Intentional product use issue 23.85 10.18 49 79530 42449 29452499
Antidepressant drug level above therapeutic 23.78 10.18 11 79568 170 29494778
Logorrhoea 23.67 10.18 30 79549 2258 29492690
Treatment failure 23.01 10.18 40 79539 36899 29458049
Circadian rhythm sleep disorder 23.00 10.18 14 79565 386 29494562
Bradypnoea 22.83 10.18 30 79549 2341 29492607
Panic attack 22.51 10.18 61 79518 8265 29486683
Hallucination, visual 22.50 10.18 90 79489 14925 29480023
Drug use disorder 22.30 10.18 36 79543 3386 29491562
Neutropenia 21.73 10.18 238 79341 131473 29363475
Distributive shock 21.08 10.18 19 79560 966 29493982
Abnormal dreams 21.07 10.18 53 79526 6867 29488081
Poor quality sleep 20.58 10.18 54 79525 7179 29487769
Myelosuppression 20.48 10.18 4 79575 12223 29482725
Anger 20.27 10.18 70 79509 10820 29484128
Victim of chemical submission 20.27 10.18 7 79572 47 29494901
Tachyphrenia 20.14 10.18 20 79559 1149 29493799
Analgesic drug level above therapeutic 20.09 10.18 11 79568 247 29494701
Hypokinesia 20.08 10.18 55 79524 7499 29487449
Drug screen positive 19.54 10.18 36 79543 3765 29491183
General physical health deterioration 19.39 10.18 180 79399 102677 29392271
Infection 19.31 10.18 124 79455 76627 29418321
Altered state of consciousness 19.30 10.18 105 79474 19784 29475164
Dyspnoea 19.16 10.18 703 78876 326029 29168919
Infusion related reaction 18.87 10.18 58 79521 43828 29451120
Anterograde amnesia 18.84 10.18 9 79570 150 29494798
Irritability 18.27 10.18 112 79467 22040 29472908
Erythema 18.09 10.18 124 79455 75482 29419466
Major depression 18.07 10.18 35 79544 3800 29491148
Cardiac arrest 17.99 10.18 327 79252 85264 29409684
Hyperlipidaemia 17.71 10.18 74 79505 12516 29482432
Rectal haemorrhage 17.61 10.18 42 79537 34507 29460441
Sepsis 17.24 10.18 275 79304 142407 29352541
Encephalomalacia 17.06 10.18 15 79564 738 29494210
Sleep talking 16.93 10.18 12 79567 430 29494518
Sleep disorder 16.88 10.18 118 79461 24268 29470680
Sleep apnoea syndrome 16.47 10.18 92 79487 17507 29477441
Product use issue 16.29 10.18 77 79502 51367 29443581
Paranoia 16.27 10.18 61 79518 9816 29485132
Sexual abuse 16 10.18 8 79571 148 29494800
Inappropriate antidiuretic hormone secretion 15.96 10.18 65 79514 10867 29484081
Asthma 15.82 10.18 43 79536 33806 29461142
Galactorrhoea 15.80 10.18 11 79568 383 29494565
Condition aggravated 15.72 10.18 288 79291 146007 29348941
Procalcitonin abnormal 15.62 10.18 10 79569 302 29494646
Feeling abnormal 15.58 10.18 219 79360 54226 29440722
Synovitis 15.47 10.18 5 79574 10885 29484063
Stress at work 15.44 10.18 8 79571 160 29494788
Loss of personal independence in daily activities 15.43 10.18 28 79551 25412 29469536
Amimia 15.31 10.18 4 79575 8 29494940
Cardiac failure 15.26 10.18 138 79441 79149 29415799
Leukopenia 15.02 10.18 87 79492 55116 29439832
Apallic syndrome 14.98 10.18 9 79570 242 29494706
Drug withdrawal convulsions 14.93 10.18 17 79562 1144 29493804
Hallucination, auditory 14.78 10.18 58 79521 9535 29485413
Drug detoxification 14.59 10.18 8 79571 180 29494768
Coagulation factor VII level decreased 14.59 10.18 7 79572 118 29494830
Product substitution issue 14.57 10.18 56 79523 9116 29485832
Dysarthria 14.56 10.18 137 79442 30774 29464174
Urticaria 14.42 10.18 87 79492 54573 29440375
Product dose omission issue 14.39 10.18 178 79401 96205 29398743
Neurotoxicity 14.31 10.18 11 79568 14602 29480346
Exposure via ingestion 14.21 10.18 22 79557 1996 29492952
Renal impairment 14.20 10.18 145 79434 81188 29413760
Drug diversion 14.15 10.18 14 79565 801 29494147
Tubulointerstitial nephritis 14.08 10.18 16 79563 17627 29477321
Nervousness 14.03 10.18 64 79515 11242 29483706
Skin laceration 14.01 10.18 63 79516 10999 29483949
Mania 13.85 10.18 53 79526 8610 29486338
Heart rate decreased 13.74 10.18 29 79550 24883 29470065
Labelled drug-food interaction medication error 13.62 10.18 5 79574 41 29494907
Peripheral swelling 13.58 10.18 108 79471 63631 29431317
Personality change 13.58 10.18 35 79544 4603 29490345
Transplant rejection 13.49 10.18 4 79575 9208 29485740
Substance-induced mood disorder 13.38 10.18 6 79573 86 29494862
Stress cardiomyopathy 13.30 10.18 19 79560 1605 29493343
Depressed level of consciousness 13.28 10.18 155 79424 36787 29458161
Pyrexia 13.22 10.18 636 78943 286986 29207962
Congenital hydrocephalus 13.19 10.18 6 79573 89 29494859
Libido decreased 13.17 10.18 33 79546 4265 29490683
Akathisia 13.13 10.18 44 79535 6698 29488250
Psychomotor hyperactivity 12.93 10.18 50 79529 8163 29486785
Alcohol use 12.87 10.18 27 79552 3105 29491843
Slow speech 12.78 10.18 14 79565 902 29494046
Hospitalisation 12.77 10.18 72 79507 45916 29449032
Dry mouth 12.58 10.18 101 79478 21683 29473265
Pulmonary fibrosis 12.58 10.18 14 79565 15568 29479380
Mental status changes 12.31 10.18 146 79433 34781 29460167
Prescription form tampering 12.29 10.18 10 79569 442 29494506
Implant site inflammation 12.25 10.18 6 79573 106 29494842
Labelled drug-drug interaction medication error 12.11 10.18 9 79570 12150 29482798
Psychotic disorder 12.10 10.18 95 79484 20259 29474689
Pilonidal cyst congenital 11.96 10.18 4 79575 24 29494924
Drug resistance 11.95 10.18 25 79554 21515 29473433
Toxic epidermal necrolysis 11.91 10.18 19 79560 18134 29476814
Self-medication 11.83 10.18 21 79558 2133 29492815
Pneumothorax traumatic 11.72 10.18 5 79574 63 29494885
Aspergillus infection 11.65 10.18 7 79572 10574 29484374
Amnestic disorder 11.56 10.18 7 79572 191 29494757
Vascular dementia 11.56 10.18 10 79569 481 29494467
Atelectasis 11.56 10.18 76 79503 15316 29479632
Victim of homicide 11.54 10.18 6 79573 121 29494827
Labile hypertension 11.45 10.18 5 79574 67 29494881
COVID-19 11.34 10.18 54 79525 35960 29458988
Emotional distress 11.29 10.18 70 79509 13825 29481123
Neutropenic sepsis 11.27 10.18 9 79570 11718 29483230
Scar pain 11.19 10.18 5 79574 71 29494877
Pre-existing condition improved 11.16 10.18 21 79558 2232 29492716
Mental disorder 11.12 10.18 66 79513 12839 29482109
Blood pressure fluctuation 11.11 10.18 23 79556 19871 29475077
Hyperhidrosis 11.01 10.18 239 79340 64301 29430647
Bipolar disorder 10.84 10.18 26 79553 3269 29491679
Gastrooesophageal reflux disease 10.81 10.18 131 79448 31365 29463583
Euphoric mood 10.77 10.18 33 79546 4792 29490156
Alcohol interaction 10.76 10.18 23 79556 2680 29492268
Erectile dysfunction 10.68 10.18 84 79495 17925 29477023
Decreased interest 10.68 10.18 20 79559 2118 29492830
Thrombotic microangiopathy 10.65 10.18 5 79574 8676 29486272
Drug half-life reduced 10.63 10.18 3 79576 9 29494939
Acute hepatic failure 10.48 10.18 10 79569 11942 29483006
Pruritus 10.46 10.18 237 79342 116612 29378336
Miosis 10.43 10.18 46 79533 7963 29486985
Hangover 10.41 10.18 13 79566 964 29493984
Product administration error 10.35 10.18 70 79509 14240 29480708
Hypovolaemia 10.32 10.18 46 79533 7999 29486949
Bradycardia 10.25 10.18 120 79459 65509 29429439

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1343.35 9.63 2241 167788 222173 64106530
Somnambulism 674.11 9.63 310 169719 4831 64323872
Drug dependence 670.66 9.63 615 169414 32697 64296006
Drug abuse 614.74 9.63 1185 168844 131189 64197514
Intentional overdose 555.03 9.63 912 169117 89032 64239671
Amnesia 421.60 9.63 576 169453 47693 64281010
Suicide attempt 395.49 9.63 688 169341 70319 64258384
Sopor 331.42 9.63 400 169629 29261 64299442
Off label use 289.22 9.63 791 169238 632015 63696688
Intentional self-injury 284.99 9.63 367 169662 28677 64300026
Poisoning 259.16 9.63 304 169725 21575 64307128
Abnormal sleep-related event 252.29 9.63 91 169938 722 64327981
Drug ineffective 248.62 9.63 1257 168772 838990 63489713
Anxiety 239.16 9.63 1113 168916 201536 64127167
Intentional product misuse 238.92 9.63 564 169465 71731 64256972
Overdose 238.91 9.63 942 169087 158624 64170079
Drug intolerance 229.65 9.63 104 169925 187888 64140815
Respiratory arrest 228.25 9.63 460 169569 52525 64276178
Drug withdrawal syndrome 224.22 9.63 340 169689 30951 64297752
Synovitis 209.39 9.63 13 170016 99077 64229626
Depression 203.36 9.63 989 169040 182302 64146401
Joint swelling 193.24 9.63 170 169859 215212 64113491
Contraindicated product administered 184.75 9.63 31 169998 107798 64220905
Toxicity to various agents 174.05 9.63 1589 168440 361924 63966779
Somnolence 165.19 9.63 1009 169020 202636 64126067
Poisoning deliberate 162.72 9.63 189 169840 13269 64315434
Infusion related reaction 161.00 9.63 119 169910 164348 64164355
Cardio-respiratory arrest 155.41 9.63 591 169438 97802 64230901
Rheumatoid arthritis 151.81 9.63 126 169903 164168 64164535
Treatment failure 151.64 9.63 59 169970 116757 64211946
Delirium 150.92 9.63 463 169566 68731 64259972
Suicidal ideation 149.58 9.63 450 169579 66092 64262611
Road traffic accident 139.69 9.63 273 169756 30472 64298231
Hand deformity 136.41 9.63 7 170022 62764 64265939
Lower respiratory tract infection 136.34 9.63 40 169989 94574 64234129
Coma 135.67 9.63 523 169506 87092 64241611
Sleep-related eating disorder 134.95 9.63 55 169974 627 64328076
Peripheral swelling 124.11 9.63 226 169803 208927 64119776
Fall 123.39 9.63 1657 168372 415169 63913534
Abnormal behaviour 119.49 9.63 270 169759 33352 64295351
Disorientation 119.35 9.63 371 169658 55457 64273246
Insomnia 109.21 9.63 893 169136 196943 64131760
Confusional state 108.25 9.63 1108 168921 260036 64068667
Systemic lupus erythematosus 107.88 9.63 35 169994 77577 64251126
Hypersensitivity 104.73 9.63 226 169803 196226 64132477
Bradyphrenia 100.42 9.63 124 169905 9282 64319421
Maternal exposure during pregnancy 99.59 9.63 65 169964 95819 64232884
Arthropathy 98.50 9.63 104 169925 120863 64207840
Drug abuser 95.57 9.63 96 169933 5712 64322991
Product use in unapproved indication 94.29 9.63 203 169826 176415 64152288
Loss of consciousness 89.14 9.63 683 169346 147682 64181021
Homicide 87.58 9.63 48 169981 1103 64327600
Restlessness 86.52 9.63 266 169763 39519 64289184
Withdrawal syndrome 86.10 9.63 191 169838 23301 64305402
Infection 84.10 9.63 231 169798 184649 64144054
Pericarditis 80.41 9.63 32 169997 62484 64266219
Glossodynia 78.60 9.63 36 169993 64660 64264043
Impaired driving ability 78.56 9.63 78 169951 4576 64324127
Drug use disorder 76.51 9.63 87 169942 5967 64322736
Arthralgia 74.84 9.63 775 169254 441485 63887218
Duodenal ulcer perforation 74.79 9.63 4 170025 34621 64294082
Automatism 72.83 9.63 24 170005 140 64328563
Hallucination 71.64 9.63 380 169649 72408 64256295
Wound 71.41 9.63 58 169971 76419 64252284
Agitation 70.99 9.63 437 169592 87930 64240773
Therapeutic product effect incomplete 70.54 9.63 102 169927 103380 64225323
Dependence 68.82 9.63 52 169977 2103 64326600
Helicobacter infection 68.02 9.63 10 170019 38352 64290351
Cardiac arrest 64.85 9.63 656 169373 153408 64175295
Affect lability 63.42 9.63 97 169932 8893 64319810
Nasopharyngitis 60.60 9.63 288 169741 195785 64132918
Rash 60.57 9.63 848 169181 457701 63871002
Alopecia 60.04 9.63 229 169800 165461 64163242
Swelling 58.99 9.63 220 169809 159998 64168705
Product use issue 58.72 9.63 204 169825 151511 64177192
Hepatic enzyme increased 58.59 9.63 163 169866 129780 64198923
Bradypnoea 58.30 9.63 70 169959 5089 64323614
Miosis 56.89 9.63 115 169914 13151 64315552
Intentional product use issue 56.55 9.63 103 169926 95261 64233442
Parasomnia 56.11 9.63 27 170002 468 64328235
Musculoskeletal stiffness 55.96 9.63 154 169875 123052 64205651
Drug hypersensitivity 55.85 9.63 382 169647 237433 64091270
Mental status changes 55.27 9.63 312 169717 60850 64267853
Blood pressure fluctuation 54.08 9.63 35 169994 51836 64276867
Dissociative disorder 53.98 9.63 25 170004 396 64328307
Neutropenia 53.30 9.63 391 169638 239233 64089470
Immobilisation prolonged 52.50 9.63 17 170012 93 64328610
Hallucination, visual 52.27 9.63 177 169852 27657 64301046
Drug withdrawal convulsions 52.24 9.63 44 169985 2084 64326619
Initial insomnia 51.75 9.63 70 169959 5734 64322969
Incoherent 50.49 9.63 77 169952 7041 64321662
Abdominal discomfort 50.01 9.63 279 169750 182043 64146660
Exposure via ingestion 49.73 9.63 63 169966 4839 64323864
Mydriasis 48.96 9.63 118 169911 15194 64313509
Altered state of consciousness 48.95 9.63 214 169815 37688 64291015
Sleep disorder due to general medical condition, insomnia type 48.59 9.63 6 170023 26264 64302439
Mental disorder 46.90 9.63 165 169864 26280 64302423
Psychomotor skills impaired 46.48 9.63 54 169975 3791 64324912
Condition aggravated 45.21 9.63 700 169329 371726 63956977
Gun shot wound 43.90 9.63 30 169999 1034 64327669
Dysarthria 42.90 9.63 286 169743 59120 64269583
Folliculitis 42.80 9.63 13 170016 30064 64298639
Sleep talking 42.79 9.63 29 170000 986 64327717
Tremor 42.74 9.63 587 169442 147643 64181060
Therapeutic product effect decreased 42.70 9.63 158 169871 115193 64213510
Aggression 42.53 9.63 237 169792 45995 64282708
Logorrhoea 42.51 9.63 53 169976 4006 64324697
Blister 41.58 9.63 95 169934 80872 64247831
Memory impairment 41.56 9.63 376 169653 85306 64243397
Akathisia 41.52 9.63 93 169936 11417 64317286
Disturbance in attention 41.48 9.63 216 169813 40858 64287845
Cytomegalovirus infection 40.30 9.63 24 170005 37175 64291528
Acute kidney injury 39.72 9.63 892 169137 448348 63880355
Dyspnoea 39.27 9.63 1524 168505 717150 63611553
Drug tolerance 39.23 9.63 63 169966 6022 64322681
Septic shock 38.00 9.63 146 169883 105291 64223412
Emotional distress 37.42 9.63 191 169838 35847 64292856
Nightmare 36.38 9.63 130 169899 20863 64307840
Depressed level of consciousness 35.81 9.63 350 169679 81086 64247617
Behaviour disorder 35.58 9.63 51 169978 4411 64324292
Urticaria 35.37 9.63 235 169794 147082 64181621
Hypokinesia 35.18 9.63 110 169919 16486 64312217
High risk sexual behaviour 34.59 9.63 7 170022 0 64328703
Substance abuse 34.55 9.63 76 169953 9216 64319487
Legal problem 34.32 9.63 14 170015 160 64328543
Red blood cell sedimentation rate increased 34.05 9.63 20 170009 31215 64297488
Hallucination, auditory 33.84 9.63 110 169919 16829 64311874
Psychomotor hyperactivity 33.65 9.63 99 169930 14352 64314351
Panic attack 33.16 9.63 126 169903 20827 64307876
Parkinsonism 33.03 9.63 98 169931 14275 64314428
Angioedema 33.00 9.63 71 169958 61750 64266953
Major depression 32.62 9.63 67 169962 7749 64320954
Gastrointestinal disorder 32.47 9.63 124 169905 89585 64239118
Euphoric mood 31.74 9.63 60 169969 6531 64322172
Muscle injury 31.66 9.63 15 170014 26422 64302281
Anterograde amnesia 31.14 9.63 20 170009 620 64328083
Blood pressure systolic increased 30.59 9.63 52 169977 49401 64279302
Cough 30.48 9.63 587 169442 301561 64027142
Erythema 30.26 9.63 331 169698 186739 64141964
Head injury 29.97 9.63 168 169861 32674 64296029
Drug screen positive 29.91 9.63 54 169975 5675 64323028
Listless 29.82 9.63 40 169989 3250 64325453
Persistent genital arousal disorder 29.71 9.63 14 170015 231 64328472
Irritability 29.67 9.63 182 169847 36564 64292139
Drug detoxification 29.23 9.63 14 170015 240 64328463
Exposure during pregnancy 29 9.63 106 169923 77569 64251134
Anaphylactic reaction 28.85 9.63 89 169940 68575 64260128
Hyponatraemia 28.72 9.63 550 169479 147789 64180914
Anger 28.59 9.63 99 169930 15642 64313061
Carotid artery thrombosis 28.31 9.63 29 170000 1766 64326937
Personality disorder 27.98 9.63 47 169982 4664 64324039
Injury 27.80 9.63 247 169782 55745 64272958
Product substitution issue 27.11 9.63 106 169923 17755 64310948
Multiple organ dysfunction syndrome 26.81 9.63 157 169872 101256 64227447
Death 26.64 9.63 1022 169007 481683 63847020
Drug resistance 26.57 9.63 32 169997 35070 64293633
Mucosal inflammation 26.38 9.63 81 169948 62503 64266200
COVID-19 26.27 9.63 86 169943 65054 64263649
Wheezing 26.27 9.63 116 169913 80463 64248240
Pruritus 26.24 9.63 625 169404 311775 64016928
Alcohol use 26.12 9.63 45 169984 4557 64324146
Reduced facial expression 26.09 9.63 30 169999 2083 64326620
Discomfort 26.02 9.63 117 169912 80761 64247942
General physical health deterioration 25.52 9.63 382 169647 204043 64124660
Hyperlipidaemia 25.43 9.63 124 169905 22852 64305851
Neurologic neglect syndrome 25.26 9.63 26 170003 1592 64327111
Inappropriate antidiuretic hormone secretion 25.18 9.63 121 169908 22168 64306535
Tension 25.09 9.63 40 169989 3800 64324903
Myelosuppression 24.94 9.63 16 170013 23814 64304889
Pyrexia 24.77 9.63 1212 168817 557432 63771271
Premature delivery 24.76 9.63 9 170020 18580 64310123
Renal impairment 24.68 9.63 232 169797 134785 64193918
C-reactive protein increased 24.52 9.63 148 169881 94761 64233942
Apathy 24.32 9.63 75 169954 11157 64317546
Imprisonment 24.19 9.63 16 170013 522 64328181
Productive cough 24.10 9.63 105 169924 73098 64255605
Ill-defined disorder 24.01 9.63 50 169979 44002 64284701
Oedematous pancreatitis 23.13 9.63 19 170010 869 64327834
Laryngeal pain 22.96 9.63 48 169981 5620 64323083
Neurotoxicity 22.93 9.63 23 170006 27381 64301322
Psychotic disorder 22.91 9.63 163 169866 34415 64294288
Pathogen resistance 22.87 9.63 3 170026 12540 64316163
Self-medication 22.84 9.63 40 169989 4105 64324598
Inadequate analgesia 22.71 9.63 39 169990 3939 64324764
Heart rate decreased 22.69 9.63 72 169957 54995 64273708
Inflammation 22.52 9.63 92 169937 65208 64263495
Impaired healing 22.26 9.63 83 169946 60390 64268313
Drug tolerance increased 22.11 9.63 16 170013 605 64328098
Labelled drug-drug interaction medication error 21.52 9.63 16 170013 22046 64306657
Victim of chemical submission 21.43 9.63 12 170017 288 64328415
Brain contusion 21.35 9.63 21 170008 1218 64327485
Adjustment disorder 21.34 9.63 31 169998 2714 64325989
Toxic epidermal necrolysis 21.27 9.63 41 169988 37125 64291578
Stress cardiomyopathy 21.16 9.63 63 169966 9194 64319509
Obstructive airways disorder 21.12 9.63 18 170011 23167 64305536
Mania 21.06 9.63 92 169937 16194 64312509
Transplant rejection 20.64 9.63 10 170019 17391 64311312
Abnormal dreams 20.46 9.63 67 169962 10289 64318414
Galactorrhoea 20.31 9.63 33 169996 3186 64325517
Accidental poisoning 20.29 9.63 22 170007 1431 64327272
Multiple sclerosis relapse 20.18 9.63 181 169848 40954 64287749
Asthma 19.90 9.63 158 169871 95067 64233636
Multiple drug therapy 19.82 9.63 27 170002 2227 64326476
Panic disorder 19.80 9.63 30 169999 2727 64325976
Encephalomalacia 19.75 9.63 19 170010 1072 64327631
Analgesic drug level above therapeutic 19.74 9.63 13 170016 421 64328282
Bronchopulmonary aspergillosis 19.72 9.63 13 170016 19072 64309631
Febrile neutropenia 19.70 9.63 362 169667 187295 64141408
Prescription drug used without a prescription 19.69 9.63 29 170000 2571 64326132
Femoral neck fracture 19.59 9.63 59 169970 8665 64320038
Bipolar disorder 19.40 9.63 50 169979 6711 64321992
Deep vein thrombosis 19.34 9.63 387 169642 104795 64223908
Drug diversion 19.10 9.63 19 170010 1117 64327586
Prothrombin time shortened 19.06 9.63 30 169999 2819 64325884
Unresponsive to stimuli 19.03 9.63 210 169819 50183 64278520
Psoriatic arthropathy 18.97 9.63 55 169974 43226 64285477
Feeling drunk 18.92 9.63 37 169992 4130 64324573
Illusion 18.89 9.63 22 170007 1548 64327155
Pulmonary fibrosis 18.86 9.63 31 169998 29847 64298856
Hepatotoxicity 18.85 9.63 49 169980 39913 64288790
Thinking abnormal 18.71 9.63 70 169959 11486 64317217
Hyperhidrosis 18.63 9.63 446 169583 124474 64204229
Urinary retention 18.56 9.63 205 169824 48996 64279707
Epstein-Barr virus infection 18.50 9.63 5 170024 12483 64316220
Vision blurred 18.21 9.63 337 169692 89979 64238724
Bulimia nervosa 18.16 9.63 10 170019 232 64328471
Victim of homicide 18.10 9.63 9 170020 168 64328535
Multiple sclerosis 18.02 9.63 98 169931 18843 64309860
Diarrhoea 17.95 9.63 1651 168378 721053 63607650
Self-injurious ideation 17.81 9.63 31 169998 3166 64325537
Injection site pain 17.65 9.63 198 169831 111210 64217493
Arthritis 17.55 9.63 139 169890 83675 64245028
Cholecystitis chronic 17.38 9.63 59 169970 9228 64319475
Blood pressure diastolic decreased 17.23 9.63 20 170009 22281 64306422
Hangover 17.06 9.63 23 170006 1878 64326825
Urinary hesitation 16.96 9.63 32 169997 3478 64325225
Facial nerve disorder 16.73 9.63 14 170015 657 64328046
Herpes zoster 16.73 9.63 131 169898 79056 64249647
Blood pressure systolic abnormal 16.71 9.63 3 170026 9939 64318764
Decreased interest 16.69 9.63 31 169998 3329 64325374
Poor quality sleep 16.67 9.63 96 169933 18855 64309848
Bone erosion 16.52 9.63 5 170024 11590 64317113
Aplastic anaemia 16.51 9.63 8 170021 13912 64314791
Dysphoria 16.44 9.63 36 169993 4352 64324351
Foreign body 16.44 9.63 26 170003 2453 64326250
Thrombotic microangiopathy 16.34 9.63 12 170017 16643 64312060
Inappropriate schedule of product administration 16.25 9.63 160 169869 92126 64236577
Posterior reversible encephalopathy syndrome 16.24 9.63 22 170007 22924 64305779
Feeling abnormal 16.16 9.63 464 169565 133138 64195565
Oropharyngeal pain 16.11 9.63 153 169876 88714 64239989
Enthesopathy 16 9.63 3 170026 9635 64319068
Sudden onset of sleep 15.91 9.63 13 170016 590 64328113
Distributive shock 15.79 9.63 22 170007 1853 64326850
Post transplant lymphoproliferative disorder 15.78 9.63 3 170026 9541 64319162
Stomatitis 15.75 9.63 199 169830 109406 64219297
Procalcitonin abnormal 15.72 9.63 10 170019 305 64328398
Rhabdomyolysis 15.72 9.63 334 169695 91392 64237311
Muscle rigidity 15.69 9.63 89 169940 17384 64311319
Victim of sexual abuse 15.68 9.63 11 170018 396 64328307
Live birth 15.66 9.63 5 170024 11199 64317504
Bone marrow failure 15.65 9.63 69 169960 47883 64280820
Hip arthroplasty 15.60 9.63 20 170009 21331 64307372
Libido decreased 15.44 9.63 37 169992 4747 64323956
Bipolar I disorder 15.25 9.63 21 170008 1750 64326953
Device expulsion 15.23 9.63 20 170009 21116 64307587
Skin ulcer 15.13 9.63 62 169967 43912 64284791
Delusion 15.03 9.63 90 169939 17924 64310779
Labelled drug-food interaction medication error 14.99 9.63 6 170023 65 64328638
Inappropriate schedule of product discontinuation 14.82 9.63 3 170026 0 64328703
Antidepressant drug level above therapeutic 14.77 9.63 12 170017 540 64328163
Therapeutic response decreased 14.76 9.63 79 169950 52109 64276594
Nervousness 14.47 9.63 130 169899 29426 64299277
Tardive dyskinesia 14.36 9.63 55 169974 9123 64319580
Tachyphrenia 14.31 9.63 21 170008 1855 64326848
Nephropathy toxic 14.31 9.63 15 170014 17499 64311204
Mobility decreased 14.22 9.63 151 169878 85689 64243014
Depressed mood 14.18 9.63 168 169861 40844 64287859
Disinhibition 14.16 9.63 23 170006 2220 64326483
Cholecystectomy 14.14 9.63 50 169979 7982 64320721
Circadian rhythm sleep disorder 14.04 9.63 12 170017 580 64328123
Generalised anxiety disorder 13.98 9.63 21 170008 1894 64326809
Dysuria 13.98 9.63 171 169858 41886 64286817
Perseveration 13.96 9.63 10 170019 372 64328331
Coagulation factor VII level decreased 13.96 9.63 8 170021 201 64328502
Sepsis 13.95 9.63 482 169547 229859 64098844
Intervertebral disc degeneration 13.94 9.63 70 169959 13050 64315653
Neutropenic sepsis 13.91 9.63 25 170004 23247 64305456
Fear 13.89 9.63 96 169933 20075 64308628
Apallic syndrome 13.77 9.63 14 170015 845 64327858
Diabetic ketoacidosis 13.77 9.63 37 169992 29808 64298895
Accidental overdose 13.67 9.63 142 169887 33415 64295288
Mouth ulceration 13.66 9.63 42 169987 32402 64296301
Speech disorder 13.61 9.63 191 169838 48250 64280453
Blastocystis infection 13.57 9.63 4 170025 15 64328688
Therapy non-responder 13.47 9.63 110 169919 65789 64262914
Poor venous access 13.46 9.63 8 170021 12409 64316294
Persistent depressive disorder 13.40 9.63 15 170014 1011 64327692
Atelectasis 13.39 9.63 120 169909 27146 64301557
Product dose omission issue 13.35 9.63 401 169628 194346 64134357
Sinusitis 13.35 9.63 288 169741 145640 64183063
Lethargy 13.31 9.63 267 169762 72327 64256376
Skin necrosis 13.21 9.63 11 170018 14318 64314385
Dysphagia 13.20 9.63 372 169657 106440 64222263
Cardiomegaly 13.08 9.63 107 169922 23577 64305126
Immunodeficiency 12.96 9.63 14 170015 16110 64312593
Staring 12.94 9.63 23 170006 2387 64326316
Hypertensive heart disease 12.90 9.63 30 169999 3774 64324929
Tachycardia 12.84 9.63 499 169530 149080 64179623
Haematocrit decreased 12.83 9.63 209 169820 54446 64274257
Labelled drug-food interaction issue 12.82 9.63 4 170025 19 64328684
Diplopia 12.74 9.63 117 169912 26648 64302055
Depressive symptom 12.65 9.63 33 169996 4463 64324240
Sinus tachycardia 12.55 9.63 135 169894 32053 64296650
Homicidal ideation 12.52 9.63 27 170002 3230 64325473
Social anxiety disorder 12.50 9.63 10 170019 440 64328263
Coagulation factor VIII level increased 12.34 9.63 4 170025 22 64328681
Pneumonia 12.24 9.63 1290 168739 558286 63770417
Adverse drug reaction 12.22 9.63 70 169959 45394 64283309
Suspected suicide 12.05 9.63 50 169979 8604 64320099
Drug dependence, antepartum 12.04 9.63 4 170025 24 64328679
Hiatus hernia 12.03 9.63 92 169937 19865 64308838
Substance-induced mood disorder 12.02 9.63 6 170023 113 64328590
Eustachian tube disorder 11.97 9.63 5 170024 61 64328642
Feeling of despair 11.90 9.63 23 170006 2545 64326158
Attention deficit hyperactivity disorder 11.86 9.63 24 170005 2746 64325957
Aspartate aminotransferase increased 11.84 9.63 406 169623 119382 64209321
Peptic ulcer 11.79 9.63 36 169993 5327 64323376
Anhedonia 11.77 9.63 69 169960 13637 64315066
Syncope 11.73 9.63 518 169511 157117 64171586
Neurogenic bladder 11.69 9.63 28 170001 3591 64325112
Cerebral atrophy 11.68 9.63 44 169985 7241 64321462
Bronchiectasis 11.68 9.63 12 170017 14128 64314575
Blood potassium decreased 11.63 9.63 160 169869 40239 64288464
Abulia 11.59 9.63 13 170016 878 64327825
Eating disorder 11.59 9.63 80 169949 16725 64311978
Palpitations 11.58 9.63 359 169670 104129 64224574
Product complaint 11.47 9.63 62 169967 11892 64316811
Cholestatic liver injury 11.39 9.63 28 170001 3651 64325052
Dehydration 11.38 9.63 689 169340 216074 64112629
Coordination abnormal 11.38 9.63 73 169956 14891 64313812
Vertigo CNS origin 11.28 9.63 4 170025 30 64328673
Cognitive disorder 11.26 9.63 206 169823 54881 64273822
Fatigue 11.25 9.63 1768 168261 746962 63581741
Disease progression 11.18 9.63 286 169743 141394 64187309
Suicidal behaviour 11.18 9.63 24 170005 2863 64325840
Carotid artery stenosis 11.15 9.63 46 169983 7895 64320808
Acute graft versus host disease 11.12 9.63 5 170024 9079 64319624
Blood testosterone decreased 11.06 9.63 20 170009 2105 64326598
Dementia 11.03 9.63 93 169936 20673 64308030
Lactic acidosis 11.01 9.63 106 169923 61304 64267399
Tenosynovitis 11.01 9.63 9 170020 11824 64316879
Pancreatic haemorrhage 10.86 9.63 5 170024 78 64328625
Grip strength decreased 10.80 9.63 9 170020 11715 64316988
Skin haemorrhage 10.72 9.63 48 169981 8537 64320166
Loss of proprioception 10.72 9.63 11 170018 671 64328032
Leukopenia 10.71 9.63 195 169834 101047 64227656
Drug ineffective for unapproved indication 10.65 9.63 44 169985 31089 64297614
Amnestic disorder 10.62 9.63 10 170019 549 64328154
Cardiotoxicity 10.61 9.63 7 170022 10267 64318436
Therapy partial responder 10.56 9.63 7 170022 10241 64318462
Pain 10.42 9.63 1289 168740 552222 63776481
Slow speech 10.38 9.63 19 170010 2018 64326685
Refusal of treatment by relative 10.35 9.63 11 170018 699 64328004
Dysgeusia 10.35 9.63 178 169851 46869 64281834
Aspergillus infection 10.33 9.63 17 170012 16362 64312341
Left ventricular dysfunction 10.33 9.63 18 170011 16936 64311767
Therapeutic product effect increased 10.22 9.63 15 170014 1325 64327378
Paranoia 10.21 9.63 76 169953 16276 64312427
Sudden death 10.15 9.63 89 169940 20007 64308696
Pleurodesis 10.11 9.63 4 170025 42 64328661
Dyssomnia 10.11 9.63 4 170025 42 64328661
Secretion discharge 10.05 9.63 10 170019 11954 64316749
Coagulation factor V level decreased 10.04 9.63 10 170019 589 64328114
Creatinine renal clearance decreased 10.03 9.63 14 170015 14407 64314296
Respiratory disorder 10.03 9.63 55 169974 36056 64292647
Psychomotor retardation 9.91 9.63 33 169996 5110 64323593
Drug withdrawal maintenance therapy 9.86 9.63 4 170025 45 64328658
Peripheral ischaemia 9.84 9.63 46 169983 8332 64320371
Catatonia 9.82 9.63 43 169986 7577 64321126
Sleep disorder 9.77 9.63 216 169813 59493 64269210
Alanine aminotransferase abnormal 9.76 9.63 3 170026 6885 64321818
Muscle spasms 9.75 9.63 460 169569 140563 64188140
Product commingling 9.75 9.63 5 170024 100 64328603
Activation syndrome 9.69 9.63 7 170022 264 64328439
Transient ischaemic attack 9.66 9.63 167 169862 44015 64284688

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CF02 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Benzodiazepine related drugs
FDA CS M0018233 Pyridines
FDA MoA N0000000196 GABA A Agonists
FDA Chemical/Ingredient N0000007570 Pyridines
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018755 GABA Agonists
MeSH PA D058785 GABA-A Receptor Agonists
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D000068776 Sleep Aids, Pharmaceutical
CHEBI has role CHEBI:35488 central nervous system depressants
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:51373 gamma-aminobutyric acid receptor agonist
FDA PE N0000175728 Central Nervous System Depression
FDA EPC N0000175759 gamma-Aminobutyric Acid-ergic Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Initial insomnia indication 59050008
Insomnia indication 193462001
Cognitive impairment following traumatic brain injury off-label use 127295002
Arousal post traumatic brain injury off-label use 127295002
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Asthenia contraindication 13791008
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Aggressive behavior contraindication 61372001
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Disease of liver contraindication 235856003 DOID:409
Sleep automatism contraindication 247962006
Severe chronic obstructive pulmonary disease contraindication 313299006
Impaired cognition contraindication 386806002
Memory impairment contraindication 386807006
Attention deficit hyperactivity disorder contraindication 406506008




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.73 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1.75MG INTERMEZZO PURDUE PHARMA N022328 Nov. 23, 2011 DISCN TABLET SUBLINGUAL 7682628 Feb. 16, 2025 METHOD FOR TREATING INSOMNIA
3.5MG INTERMEZZO PURDUE PHARMA N022328 Nov. 23, 2011 DISCN TABLET SUBLINGUAL 7682628 Feb. 16, 2025 METHOD FOR TREATING INSOMNIA
10MG EDLUAR MYLAN SPECIALITY LP N021997 March 13, 2009 RX TABLET SUBLINGUAL 9597281 April 6, 2027 METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET
5MG EDLUAR MYLAN SPECIALITY LP N021997 March 13, 2009 RX TABLET SUBLINGUAL 9597281 April 6, 2027 METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET
1.75MG INTERMEZZO PURDUE PHARMA N022328 Nov. 23, 2011 DISCN TABLET SUBLINGUAL 7658945 April 15, 2027 METHOD FOR TREATING INSOMNIA
3.5MG INTERMEZZO PURDUE PHARMA N022328 Nov. 23, 2011 DISCN TABLET SUBLINGUAL 7658945 April 15, 2027 METHOD FOR TREATING INSOMNIA
1.75MG INTERMEZZO PURDUE PHARMA N022328 Nov. 23, 2011 DISCN TABLET SUBLINGUAL 8242131 Aug. 20, 2029 METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA
3.5MG INTERMEZZO PURDUE PHARMA N022328 Nov. 23, 2011 DISCN TABLET SUBLINGUAL 8242131 Aug. 20, 2029 METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA
10MG EDLUAR MYLAN SPECIALITY LP N021997 March 13, 2009 RX TABLET SUBLINGUAL 9265720 Feb. 25, 2031 METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET
5MG EDLUAR MYLAN SPECIALITY LP N021997 March 13, 2009 RX TABLET SUBLINGUAL 9265720 Feb. 25, 2031 METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET
5MG/SPRAY ZOLPIMIST AYTU N022196 Dec. 19, 2008 RX SPRAY, METERED ORAL 8236285 Aug. 7, 2032 TREATMENT OF TRANSIENT INSOMNIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel ALLOSTERIC MODULATOR Ki 7.68 IUPHAR IUPHAR
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 6.70 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.81 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.42 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.57 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.16 WOMBAT-PK CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel Ki 6.39 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-3 Ion channel Ki 6.01 CHEMBL
Multidrug resistance protein 1 Transporter Km 3.70 WOMBAT-PK
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel Ki 6.12 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Ki 7.46 CHEMBL
GABA A receptor alpha-6/beta-2/gamma-2 Ion channel Ki 6.01 CHEMBL
GABA-A receptor; alpha-1/beta-2/gamma-2 Ion channel Ki 7.72 CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel Ki 6.81 CHEMBL
CAAX prenyl protease 2 Enzyme AC50 4.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 7.60 CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel Ki 6.42 CHEMBL
Translocator protein Membrane receptor IC50 5.33 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel Ki 7.30 CHEMBL

External reference:

IDSource
D00706 KEGG_DRUG
99294-93-6 SECONDARY_CAS_RN
4020811 VANDF
4023596 VANDF
C0078839 UMLSCUI
CHEBI:10125 CHEBI
CHEMBL911 ChEMBL_ID
CHEMBL3989820 ChEMBL_ID
DB00425 DRUGBANK_ID
CHEMBL1723343 ChEMBL_ID
D000077334 MESH_DESCRIPTOR_UI
5732 PUBCHEM_CID
4348 IUPHAR_LIGAND_ID
5741 INN_ID
7K383OQI23 UNII
131725 RXNORM
109404 MMSL
343 MMSL
5713 MMSL
d00910 MMSL
004146 NDDF
004147 NDDF
387569009 SNOMEDCT_US
395928005 SNOMEDCT_US
96231005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ambien HUMAN PRESCRIPTION DRUG LABEL 1 0024-5401 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Ambien HUMAN PRESCRIPTION DRUG LABEL 1 0024-5401 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Ambien HUMAN PRESCRIPTION DRUG LABEL 1 0024-5421 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Ambien HUMAN PRESCRIPTION DRUG LABEL 1 0024-5421 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Ambien CR HUMAN PRESCRIPTION DRUG LABEL 1 0024-5501 TABLET, COATED 6.25 mg ORAL NDA 34 sections
Ambien CR HUMAN PRESCRIPTION DRUG LABEL 1 0024-5501 TABLET, COATED 6.25 mg ORAL NDA 34 sections
Ambien CR HUMAN PRESCRIPTION DRUG LABEL 1 0024-5521 TABLET, COATED 12.50 mg ORAL NDA 34 sections
Ambien CR HUMAN PRESCRIPTION DRUG LABEL 1 0024-5521 TABLET, COATED 12.50 mg ORAL NDA 34 sections
Edluar HUMAN PRESCRIPTION DRUG LABEL 1 0037-6010 TABLET 10 mg ORAL NDA 33 sections
Edluar HUMAN PRESCRIPTION DRUG LABEL 1 0037-6050 TABLET 5 mg ORAL NDA 33 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0086 TABLET, FILM COATED 5 mg ORAL ANDA 31 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0087 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-0073 TABLET, FILM COATED 5 mg ORAL ANDA 30 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-0074 TABLET, FILM COATED 10 mg ORAL ANDA 30 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8225 TABLET, FILM COATED 5 mg ORAL ANDA 32 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8226 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Zolpidem tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5315 TABLET, EXTENDED RELEASE 6.25 mg ORAL ANDA 32 sections
Zolpidem tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5316 TABLET, EXTENDED RELEASE 12.50 mg ORAL ANDA 32 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5317 TABLET, COATED 5 mg ORAL ANDA 31 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5318 TABLET, COATED 10 mg ORAL ANDA 31 sections
ZOLPIDEM TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6082 TABLET 5 mg ORAL ANDA 31 sections
ZOLPIDEM TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6083 TABLET 10 mg ORAL ANDA 31 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0955-1702 TABLET, FILM COATED, EXTENDED RELEASE 6.25 mg ORAL NDA AUTHORIZED GENERIC 34 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0955-1702 TABLET, FILM COATED, EXTENDED RELEASE 6.25 mg ORAL NDA AUTHORIZED GENERIC 34 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0955-1703 TABLET, FILM COATED, EXTENDED RELEASE 12.50 mg ORAL NDA AUTHORIZED GENERIC 34 sections
Zolpidem Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0955-1703 TABLET, FILM COATED, EXTENDED RELEASE 12.50 mg ORAL NDA AUTHORIZED GENERIC 34 sections
Zolpidem TartrateExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-116 TABLET, FILM COATED, EXTENDED RELEASE 12.50 mg ORAL ANDA 32 sections
Zolpidem TartrateExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-116 TABLET, FILM COATED, EXTENDED RELEASE 12.50 mg ORAL ANDA 32 sections
Zolpidem TartrateExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-117 TABLET, FILM COATED, EXTENDED RELEASE 6.25 mg ORAL ANDA 32 sections
Zolpidem TartrateExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-117 TABLET, FILM COATED, EXTENDED RELEASE 6.25 mg ORAL ANDA 32 sections