warfarin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2847 81-81-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • warfarin
  • warfarin sodium
  • warfarin potassium
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
  • Molecular weight: 308.33
  • Formula: C19H16O4
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -3.82
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
7.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.54 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.13 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.06 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 29 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 8, 1954 FDA BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 8844.96 10.40 3811 193470 42614 63249127
Drug interaction 1322.35 10.40 2470 194811 226661 63065080
Calciphylaxis 1044.61 10.40 384 196897 2688 63289053
International normalised ratio decreased 899.05 10.40 383 196898 4118 63287623
International normalised ratio abnormal 892.19 10.40 349 196932 2955 63288786
Pulmonary arterial hypertension 888.21 10.40 659 196622 21918 63269823
Drug ineffective 870.97 10.40 1192 196089 1043573 62248168
Dyspnoea 654.77 10.40 3888 193393 657425 62634316
Gastrointestinal haemorrhage 615.90 10.40 989 196292 80187 63211554
Fluid retention 600.33 10.40 830 196451 58856 63232885
Anticoagulation drug level above therapeutic 584.32 10.40 205 197076 1230 63290511
International normalised ratio fluctuation 538.80 10.40 224 197057 2254 63289487
Synovitis 531.02 10.40 10 197271 186908 63104833
Haematoma 526.33 10.40 594 196687 34226 63257515
Haemorrhage 519.33 10.40 784 196497 60238 63231503
Cardiac failure congestive 484.37 10.40 958 196323 91475 63200266
Subdural haematoma 471.04 10.40 376 196905 13952 63277789
Epistaxis 452.16 10.40 811 196470 71914 63219827
Atrial fibrillation 450.99 10.40 1069 196212 115567 63176174
Drug intolerance 447.04 10.40 200 197081 308461 62983280
Pulmonary hypertension 442.20 10.40 561 196720 36562 63255179
Contraindicated product administered 437.29 10.40 75 197206 217573 63074168
Glossodynia 424.74 10.40 35 197246 178841 63112900
Pain in jaw 418.12 10.40 592 196689 42904 63248837
Treatment failure 405.58 10.40 66 197215 198977 63092764
Infusion related reaction 402.11 10.40 131 197150 245390 63046351
Right ventricular failure 392.08 10.40 366 196915 16822 63274919
Labelled drug-drug interaction medication error 390.86 10.40 328 196953 13071 63278670
Hypervolaemia 382.98 10.40 457 196824 27956 63263785
Hand deformity 379.11 10.40 31 197250 159426 63132315
Cerebral haemorrhage 368.54 10.40 466 196815 30263 63261478
Alopecia 366.06 10.40 307 196974 337229 62954512
Catheter site erythema 361.12 10.40 202 197079 4074 63287667
Joint swelling 360.30 10.40 294 196987 327372 62964369
Arthropathy 349.55 10.40 146 197135 234646 63057095
Melaena 341.42 10.40 446 196835 29919 63261822
Rheumatoid arthritis 339.29 10.40 183 197098 253636 63038105
Dyspnoea exertional 332.81 10.40 639 196642 59663 63232078
Therapeutic product effect decreased 332.66 10.40 94 197187 193093 63098648
Prothrombin time prolonged 331.60 10.40 259 197022 9305 63282436
Cardiac failure 327.25 10.40 801 196480 88341 63203400
Off label use 326.38 10.40 1045 196236 673417 62618324
Haemoglobin decreased 315.37 10.40 1082 196199 144403 63147338
Device related infection 308.29 10.40 372 196909 23020 63268721
Systemic lupus erythematosus 302.84 10.40 135 197146 208783 63082958
Catheter site pain 288.05 10.40 181 197100 4554 63287187
Coagulopathy 286.05 10.40 336 196945 20208 63271533
Pericarditis 271.62 10.40 42 197239 131537 63160204
Anaemia 267.44 10.40 1692 195589 291738 63000003
Abdominal wall haematoma 265.31 10.40 147 197134 2908 63288833
Arthralgia 258.62 10.40 907 196374 568803 62722938
Hepatic enzyme increased 254.44 10.40 157 197124 202171 63089570
Catheter management 251.95 10.40 141 197140 2846 63288895
Hypersensitivity 251.93 10.40 324 196957 292361 62999380
Drug hypersensitivity 245.33 10.40 366 196915 310321 62981420
Transfusion 244.34 10.40 268 197013 14949 63276792
Wound 243.72 10.40 101 197180 163162 63128579
Discomfort 242.76 10.40 108 197173 167266 63124475
Musculoskeletal stiffness 242.40 10.40 136 197145 184482 63107259
Duodenal ulcer perforation 242.30 10.40 6 197275 87203 63204538
Anticoagulation drug level below therapeutic 241.08 10.40 89 197192 631 63291110
Rectal haemorrhage 240.94 10.40 495 196786 48535 63243206
Helicobacter infection 238.36 10.40 12 197269 92773 63198968
Syncope 234.47 10.40 850 196431 116535 63175206
Thrombosis 233.48 10.40 578 196703 64177 63227564
Haemorrhage intracranial 232.43 10.40 246 197035 13173 63278568
Hypotension 224.64 10.40 1533 195748 271071 63020670
Oedema peripheral 224.38 10.40 1172 196109 188339 63103402
Haemoptysis 209.51 10.40 344 196937 28382 63263359
Haematuria 205.72 10.40 344 196937 28813 63262928
Catheter site discharge 203.10 10.40 107 197174 1906 63289835
Rash 201.85 10.40 977 196304 559894 62731847
Death 201.77 10.40 1910 195371 372471 62919270
Psoriatic arthropathy 201.22 10.40 24 197257 91496 63200245
Catheter site pruritus 197.89 10.40 107 197174 2013 63289728
Pain 196.74 10.40 1422 195859 739206 62552535
Catheter site infection 192.20 10.40 143 197138 4771 63286970
Product use issue 191.85 10.40 242 197039 220278 63071463
Folliculitis 191.04 10.40 6 197275 70311 63221430
Stomatitis 178.04 10.40 105 197176 138620 63153121
Muscle haemorrhage 177.19 10.40 115 197166 3064 63288677
Central venous catheterisation 172.43 10.40 105 197176 2494 63289247
Catheter site haemorrhage 169.99 10.40 112 197169 3063 63288678
Muscle injury 166.10 10.40 9 197272 65336 63226405
Irritable bowel syndrome 164.04 10.40 29 197252 82383 63209358
Ecchymosis 160.37 10.40 185 197096 10909 63280832
Infusion site pain 156.75 10.40 226 197055 16643 63275098
Therapeutic product effect incomplete 154.43 10.40 99 197182 124957 63166784
Device leakage 152.07 10.40 146 197135 6950 63284791
Hospitalisation 150.69 10.40 593 196688 84488 63207253
Heparin-induced thrombocytopenia 147.93 10.40 119 197162 4463 63287278
Device alarm issue 144.99 10.40 78 197203 1452 63290289
Blood cholesterol increased 143.82 10.40 56 197225 93976 63197765
Abdominal discomfort 140.46 10.40 518 196763 320367 62971374
Sleep disorder due to general medical condition, insomnia type 139.92 10.40 5 197276 52212 63239529
Catheter site swelling 138.75 10.40 75 197206 1410 63290331
Maternal exposure during pregnancy 138.67 10.40 298 196983 219764 63071977
Exposure during pregnancy 138.05 10.40 168 197113 155379 63136362
Deep vein thrombosis 137.20 10.40 570 196711 83230 63208511
Catheter placement 135.65 10.40 86 197195 2198 63289543
Palpitations 135.10 10.40 700 196581 112070 63179671
Fall 135.04 10.40 1834 195447 390500 62901241
Flushing 131.88 10.40 522 196759 74565 63217176
Pulmonary embolism 131.38 10.40 712 196569 115972 63175769
Oxygen saturation decreased 130.78 10.40 584 196697 88001 63203740
Product use in unapproved indication 128.91 10.40 224 197057 178856 63112885
Oedema 128.24 10.40 622 196659 97000 63194741
Retroperitoneal haematoma 125.79 10.40 90 197191 2823 63288918
Prothrombin time abnormal 124.84 10.40 50 197231 453 63291288
Subdural haemorrhage 124.78 10.40 92 197189 3026 63288715
Coagulation time prolonged 123.89 10.40 69 197212 1379 63290362
Febrile neutropenia 122.97 10.40 112 197169 118337 63173404
Blister 120.79 10.40 135 197146 129679 63162062
Infusion site infection 117.80 10.40 72 197209 1722 63290019
Chest pain 116.15 10.40 1102 196179 214857 63076884
Sinusitis 113.41 10.40 345 196936 226308 63065433
Thrombosis in device 112.46 10.40 85 197196 2905 63288836
Impaired healing 110.01 10.40 94 197187 102448 63189293
Bradycardia 109.01 10.40 484 196797 72743 63218998
Pneumonia aspiration 108.67 10.40 293 196988 34247 63257494
Type 2 diabetes mellitus 108.13 10.40 32 197249 63836 63227905
Swelling 106.27 10.40 467 196814 274911 63016830
Ill-defined disorder 104.69 10.40 62 197219 81693 63210048
Upper gastrointestinal haemorrhage 104.22 10.40 200 197081 18652 63273089
Lower respiratory tract infection 104.12 10.40 156 197125 132151 63159590
Cerebrovascular accident 102.54 10.40 630 196651 107394 63184347
Cardiac pacemaker insertion 102.14 10.40 92 197189 4034 63287707
Hypertension 99.87 10.40 487 196794 278816 63012925
Retroperitoneal haemorrhage 99.68 10.40 77 197204 2720 63289021
General physical health deterioration 98.30 10.40 310 196971 201092 63090649
Blood pressure decreased 97.71 10.40 431 196850 64591 63227150
Skin necrosis 97.61 10.40 164 197117 13786 63277955
Infection 97.56 10.40 374 196907 228799 63062942
Pulmonary oedema 96.76 10.40 382 196899 54491 63237250
Nasal congestion 96.23 10.40 432 196849 65228 63226513
Catheter site inflammation 95.73 10.40 49 197232 820 63290921
Fibromyalgia 94.78 10.40 67 197214 80353 63211388
Lung transplant 94.17 10.40 78 197203 3050 63288691
Presyncope 91.77 10.40 240 197041 27545 63264196
Atrial flutter 89.44 10.40 130 197151 9642 63282099
Infusion site erythema 89.41 10.40 143 197138 11536 63280205
Haemorrhage subcutaneous 89.01 10.40 74 197207 2909 63288832
Cardiac valve replacement complication 85.89 10.40 28 197253 129 63291612
Pneumonia 85.34 10.40 1937 195344 454830 62836911
Liver injury 84.66 10.40 41 197240 60479 63231262
Mobility decreased 84.05 10.40 155 197126 121004 63170737
Device occlusion 83.78 10.40 109 197172 7278 63284463
Sleep disorder 83.61 10.40 78 197203 81488 63210253
Psoriasis 83.57 10.40 88 197193 86869 63204872
Osteoarthritis 82.44 10.40 105 197176 95238 63196503
Haematemesis 82.01 10.40 244 197037 30168 63261573
Injection site pain 81.51 10.40 176 197105 129624 63162117
Pulmonary arterial pressure increased 80.91 10.40 76 197205 3519 63288222
Faeces discoloured 80.65 10.40 178 197103 18331 63273410
Catheter site rash 80.58 10.40 42 197239 731 63291010
Cardiac disorder 80.30 10.40 342 196939 50474 63241267
Dialysis 80.28 10.40 128 197153 10299 63281442
Gastrointestinal disorder 79.91 10.40 181 197100 131058 63160683
Paraesthesia 79.85 10.40 237 197044 156729 63135012
Injection site reaction 79.83 10.40 41 197240 58483 63233258
Dizziness 78.67 10.40 1818 195463 428107 62863634
Shock haemorrhagic 78.30 10.40 123 197158 9772 63281969
Acute kidney injury 77.99 10.40 1200 196081 262215 63029526
Malignant neoplasm progression 77.92 10.40 84 197197 82037 63209704
Catheterisation cardiac 77.26 10.40 83 197198 4520 63287221
Urticaria 76.88 10.40 261 197020 165541 63126200
Intra-abdominal haematoma 76.18 10.40 55 197226 1750 63289991
Complication associated with device 75.93 10.40 165 197116 16813 63274928
Subarachnoid haemorrhage 75.87 10.40 149 197132 14134 63277607
Pulmonary thrombosis 75.66 10.40 113 197168 8589 63283152
Lower gastrointestinal haemorrhage 75.20 10.40 107 197174 7783 63283958
Haemorrhagic stroke 74.49 10.40 91 197190 5701 63286040
Loss of personal independence in daily activities 74.33 10.40 117 197164 97173 63194568
Neutropenia 74.19 10.40 286 196995 174719 63117022
Blood loss anaemia 74.17 10.40 114 197167 8887 63282854
Vascular device infection 73.91 10.40 102 197179 7210 63284531
Coagulation test abnormal 73.71 10.40 40 197241 758 63290983
Pruritus 73.51 10.40 743 196538 360710 62931031
C-reactive protein increased 73.21 10.40 113 197168 94594 63197147
Haemarthrosis 71.47 10.40 67 197214 3094 63288647
Intentional overdose 71.30 10.40 75 197206 74077 63217664
Asthenia 69.48 10.40 1620 195661 381984 62909757
Spinal epidural haematoma 68.35 10.40 43 197238 1084 63290657
Activated partial thromboplastin time prolonged 67.95 10.40 95 197186 6798 63284943
Depression 67.67 10.40 347 196934 196145 63095596
Device related sepsis 67.27 10.40 73 197208 4021 63287720
Drug abuse 66.79 10.40 76 197205 72442 63219299
Internal haemorrhage 66.18 10.40 81 197200 5084 63286657
Therapy change 64.75 10.40 87 197194 5994 63285747
Cardioactive drug level increased 64.45 10.40 54 197227 2146 63289595
Device expulsion 63.85 10.40 15 197266 34907 63256834
Suicidal ideation 63.61 10.40 60 197221 62361 63229380
Intra-abdominal haemorrhage 62.99 10.40 56 197225 2413 63289328
Anaphylactic reaction 62.27 10.40 68 197213 66032 63225709
Hypoaesthesia 61.06 10.40 292 196989 168101 63123640
Inflammation 60.91 10.40 101 197180 82172 63209569
Hypocoagulable state 60.81 10.40 41 197240 1166 63290575
Subcutaneous haematoma 60.58 10.40 47 197234 1671 63290070
Therapeutic response decreased 60.54 10.40 61 197220 61464 63230277
Cardiac operation 59.86 10.40 62 197219 3236 63288505
Injection site erythema 59.84 10.40 104 197177 83070 63208671
Red blood cell sedimentation rate increased 59.70 10.40 31 197250 43951 63247790
Spontaneous haematoma 59.04 10.40 36 197245 857 63290884
Intentional product use issue 58.81 10.40 202 197079 127690 63164051
Multiple sclerosis relapse 57.63 10.40 40 197241 48438 63243303
Device infusion issue 57.60 10.40 49 197232 1989 63289752
Dermatitis contact 57.46 10.40 114 197167 10894 63280847
Pulmonary endarterectomy 56.58 10.40 20 197261 123 63291618
Prosthetic cardiac valve thrombosis 56.30 10.40 15 197266 27 63291714
Leukopenia 56.19 10.40 96 197185 77194 63214547
Cardiac ablation 55.38 10.40 42 197239 1443 63290298
Asthma 54.99 10.40 207 197074 127354 63164387
Gout 54.88 10.40 125 197156 13146 63278595
COVID-19 54.50 10.40 175 197106 112928 63178813
Acute respiratory failure 54.40 10.40 232 197049 34253 63257488
Head injury 54.29 10.40 198 197083 27198 63264543
Hypercoagulation 52.62 10.40 47 197234 2038 63289703
Malaise 52.61 10.40 1677 195604 414277 62877464
Haemoperitoneum 52.42 10.40 53 197228 2688 63289053
Torsade de pointes 52.18 10.40 123 197158 13228 63278513
Pericardial haemorrhage 52.16 10.40 42 197239 1577 63290164
Catheter site irritation 52.01 10.40 28 197253 522 63291219
Vascular pseudoaneurysm 52.00 10.40 41 197240 1493 63290248
Intraventricular haemorrhage 51.95 10.40 47 197234 2073 63289668
Transplant evaluation 51.72 10.40 37 197244 1160 63290581
Mucosal inflammation 51.57 10.40 42 197239 46886 63244855
Gingival bleeding 51.43 10.40 118 197163 12469 63279272
Gastric haemorrhage 51.27 10.40 80 197201 6318 63285423
Haematoma muscle 51.11 10.40 36 197245 1101 63290640
Cellulitis 51.04 10.40 432 196849 81526 63210215
Food interaction 50.89 10.40 32 197249 806 63290935
Completed suicide 50.85 10.40 256 197025 145417 63146324
Bursitis 50.44 10.40 26 197255 37015 63254726
Renal failure 50.19 10.40 573 196708 117079 63174662
Myelosuppression 50.19 10.40 7 197274 23696 63268045
Oxygen consumption increased 49.91 10.40 61 197220 3823 63287918
Knee arthroplasty 49.71 10.40 57 197224 54149 63237592
Post procedural haemorrhage 49.67 10.40 89 197192 7875 63283866
Catheter site related reaction 49.46 10.40 33 197248 922 63290819
Hypoxia 48.92 10.40 336 196945 59456 63232285
Hip arthroplasty 48.31 10.40 46 197235 47600 63244141
Prothrombin time ratio increased 48.03 10.40 17 197264 105 63291636
Fatigue 47.83 10.40 2265 195016 885763 62405978
Haematocrit decreased 47.62 10.40 245 197036 39095 63252646
Injection site pruritus 47.59 10.40 42 197239 45074 63246667
Potentiating drug interaction 47.42 10.40 63 197218 4293 63287448
Brain natriuretic peptide increased 47.20 10.40 69 197212 5144 63286597
Injury 47.07 10.40 98 197183 73149 63218592
Prescribed overdose 46.46 10.40 24 197257 34129 63257612
Choroidal haemorrhage 46.42 10.40 14 197267 47 63291694
Medical device change 46.41 10.40 22 197259 309 63291432
Infusion site discharge 46.02 10.40 28 197253 664 63291077
Unevaluable event 45.19 10.40 294 196987 51092 63240649
Hyperkalaemia 45.18 10.40 306 196975 53897 63237844
Injection site swelling 44.74 10.40 49 197232 47523 63244218
Cerebellar haemorrhage 44.57 10.40 36 197245 1358 63290383
Pelvic haematoma 44.02 10.40 26 197255 583 63291158
Pleural effusion 43.44 10.40 462 196819 92748 63198993
Cardioversion 43.41 10.40 34 197247 1226 63290515
Dyspnoea at rest 42.89 10.40 58 197223 4021 63287720
Ventricular tachycardia 42.68 10.40 148 197133 19831 63271910
Muscle spasticity 42.64 10.40 8 197273 21786 63269955
Traumatic haematoma 42.57 10.40 36 197245 1449 63290292
Congestive hepatopathy 42.42 10.40 49 197232 2893 63288848
Cardiac failure chronic 42.23 10.40 60 197221 4358 63287383
Catheter removal 41.95 10.40 22 197259 388 63291353
Foot deformity 41.89 10.40 17 197264 27836 63263905
Respiratory failure 41.62 10.40 492 196789 101366 63190375
Dehydration 41.09 10.40 762 196519 172592 63119149
Ischaemic stroke 40.98 10.40 136 197145 17821 63273920
Catheter site discolouration 40.79 10.40 15 197266 105 63291636
Anticoagulation drug level decreased 40.56 10.40 12 197269 37 63291704
Anticoagulation drug level abnormal 40.41 10.40 9 197272 3 63291738
Prescribed underdose 40.19 10.40 21 197260 29668 63262073
Occult blood positive 39.83 10.40 53 197228 3617 63288124
Arrhythmia 39.73 10.40 228 197053 37912 63253829
Heart valve replacement 39.45 10.40 24 197257 569 63291172
Heart rate increased 39.31 10.40 457 196824 93781 63197960
Emergency care 39.22 10.40 30 197251 1044 63290697
Embolism 39.03 10.40 80 197201 7826 63283915
Cardiac failure acute 38.60 10.40 89 197192 9434 63282307
International normalised ratio 38.57 10.40 14 197267 94 63291647
Brain herniation 38.23 10.40 52 197229 3625 63288116
Foetal warfarin syndrome 38.22 10.40 8 197273 0 63291741
Atrial tachycardia 38.21 10.40 56 197225 4184 63287557
Protein C decreased 37.91 10.40 11 197270 31 63291710
Spinal cord haematoma 37.80 10.40 16 197265 169 63291572
Pericardial effusion 37.64 10.40 189 197092 29869 63261872
Tongue haematoma 37.62 10.40 13 197268 74 63291667
Ovarian haemorrhage 37.06 10.40 19 197262 319 63291422
Pulmonary haemorrhage 37.04 10.40 74 197207 7107 63284634
Sepsis 36.96 10.40 675 196606 152448 63139293
Wheezing 36.87 10.40 162 197119 95433 63196308
Dizziness postural 36.84 10.40 75 197206 7301 63284440
Antiphospholipid syndrome 36.80 10.40 36 197245 1754 63289987
Lip dry 36.75 10.40 3 197278 15467 63276274
Vascular pseudoaneurysm ruptured 36.68 10.40 12 197269 56 63291685
Ascites 36.41 10.40 234 197047 40494 63251247
Eye haemorrhage 36.22 10.40 81 197200 8415 63283326
Intestinal haematoma 36.11 10.40 13 197268 85 63291656
Drug monitoring procedure not performed 36.03 10.40 23 197258 595 63291146
Anovulatory cycle 35.89 10.40 15 197266 153 63291588
Anticoagulation drug level increased 35.70 10.40 16 197265 196 63291545
Device breakage 35.39 10.40 97 197184 11445 63280296
Orthopnoea 35.31 10.40 67 197214 6194 63285547
Infusion site cellulitis 35.27 10.40 16 197265 202 63291539
Obesity 35.22 10.40 25 197256 29927 63261814
Drug tolerance decreased 35.08 10.40 6 197275 17467 63274274
Catheter site warmth 35.06 10.40 16 197265 205 63291536
Haematoma evacuation 35.06 10.40 15 197266 163 63291578
Wrong technique in product usage process 34.75 10.40 90 197191 62250 63229491
Adrenal haemorrhage 34.69 10.40 20 197261 428 63291313
Oral herpes 34.48 10.40 19 197262 26055 63265686
Spinal subdural haematoma 34.37 10.40 14 197267 133 63291608
Mineral supplementation 34.33 10.40 24 197257 725 63291016
Device connection issue 34.18 10.40 23 197258 652 63291089
Blood viscosity decreased 34.04 10.40 11 197270 49 63291692
Intentional self-injury 33.56 10.40 19 197262 25668 63266073
Pregnancy 33.49 10.40 39 197242 36797 63254944
Cytokine release syndrome 33.39 10.40 3 197278 14311 63277430
Heart rate irregular 33.20 10.40 148 197133 22273 63269468
Blood potassium decreased 33.10 10.40 234 197047 41792 63249949
Seizure 32.88 10.40 259 197022 132375 63159366
Prothrombin consumption time prolonged 32.84 10.40 10 197271 35 63291706
Cough 32.81 10.40 1164 196117 291579 63000162
Anticoagulant-related nephropathy 32.70 10.40 8 197273 8 63291733
Oxygen therapy 32.62 10.40 37 197244 2141 63289600
Cardiac valve disease 32.46 10.40 52 197229 4200 63287541
Anxiety 32.43 10.40 478 196803 217063 63074678
Catheter site vesicles 32.41 10.40 17 197264 300 63291441
Extradural haematoma 32.39 10.40 33 197248 1689 63290052
Catheter culture positive 32.25 10.40 14 197267 158 63291583
Rheumatoid nodule 32.10 10.40 7 197274 17148 63274593
Headache 31.99 10.40 2331 194950 630910 62660831
Suicide attempt 31.67 10.40 91 197190 60827 63230914
Sedation 31.25 10.40 45 197236 38764 63252977
Aortic valve replacement 31.05 10.40 23 197258 762 63290979
Renal vascular thrombosis 31.04 10.40 10 197271 44 63291697
Infusion site warmth 30.90 10.40 33 197248 1785 63289956
Haemothorax 30.85 10.40 36 197245 2149 63289592
Night sweats 30.78 10.40 66 197215 48748 63242993
Hypovolaemic shock 30.63 10.40 63 197218 6178 63285563
Protein S decreased 30.60 10.40 9 197272 27 63291714
Hypercholesterolaemia 30.53 10.40 14 197267 21320 63270421
Illness 30.38 10.40 67 197214 48992 63242749
Central venous catheter removal 30.30 10.40 18 197263 408 63291333
Neutrophil count decreased 30.25 10.40 83 197198 56323 63235418
Ear pain 29.96 10.40 41 197240 36077 63255664
Arthritis 29.85 10.40 224 197057 115697 63176044
Grip strength decreased 29.82 10.40 16 197265 22271 63269470
Petechiae 29.73 10.40 103 197178 13794 63277947
Intracardiac thrombus 29.60 10.40 37 197244 2373 63289368
Psychotic disorder 29.53 10.40 22 197259 25690 63266051
Accidental exposure to product 29.53 10.40 25 197256 27380 63264361
Joint stiffness 29.52 10.40 53 197228 41816 63249925
Coma 29.50 10.40 318 196963 64046 63227695
Accidental overdose 29.49 10.40 147 197134 23162 63268579
Cerebral haematoma 29.44 10.40 46 197235 3637 63288104
Drug dependence 29.36 10.40 20 197261 24463 63267278
Mediastinal haematoma 29.32 10.40 11 197270 82 63291659
Product complaint 29.22 10.40 97 197184 12712 63279029
Breast haematoma 29.20 10.40 14 197267 202 63291539
Gangrene 29.10 10.40 61 197220 6062 63285679
Vaginal haemorrhage 29.08 10.40 165 197116 27322 63264419
Osteoporosis 28.83 10.40 87 197194 57251 63234490
Haematochezia 28.60 10.40 273 197008 53271 63238470
Condition aggravated 28.57 10.40 993 196288 401224 62890517
Basal cell carcinoma 28.40 10.40 27 197254 27964 63263777
Acute myeloid leukaemia 28.28 10.40 9 197272 17138 63274603
Cerebral mass effect 27.97 10.40 23 197258 890 63290851
Immunodeficiency 27.90 10.40 14 197267 20240 63271501
Calcium deficiency 27.89 10.40 25 197256 1089 63290652
Cardiac arrest 27.86 10.40 423 196858 92122 63199619
Dilatation ventricular 27.61 10.40 36 197245 2409 63289332
Atrial thrombosis 27.43 10.40 31 197250 1787 63289954
Myxoedema coma 27.39 10.40 17 197264 418 63291323
Vitamin K deficiency 27.22 10.40 17 197264 423 63291318
Sciatic nerve palsy 27.20 10.40 8 197273 24 63291717
Facet joint syndrome 27.13 10.40 3 197278 12135 63279606
Lupus-like syndrome 27.12 10.40 7 197274 15288 63276453
Diarrhoea 26.99 10.40 2576 194705 712790 62578951
Bradyarrhythmia 26.83 10.40 33 197248 2082 63289659
Joint range of motion decreased 26.71 10.40 37 197244 32391 63259350
Intestinal haemorrhage 26.61 10.40 45 197236 3802 63287939
Abdominal distension 26.50 10.40 397 196884 86218 63205523
Breast necrosis 26.35 10.40 12 197269 153 63291588
Colitis 26.33 10.40 71 197210 48457 63243284
Hepatotoxicity 26.02 10.40 47 197234 36994 63254747
Infusion site swelling 25.97 10.40 78 197203 9692 63282049
Haemorrhagic diathesis 25.84 10.40 48 197233 4367 63287374
Drug level changed 25.81 10.40 13 197268 210 63291531
Infusion site abscess 25.81 10.40 13 197268 210 63291531
Lethargy 25.80 10.40 277 197004 55730 63236011
Infusion site haemorrhage 25.74 10.40 52 197229 5034 63286707
Mitral valve disease 25.68 10.40 35 197246 2445 63289296
Pyrexia 25.58 10.40 1198 196083 469280 62822461
Pancytopenia 25.58 10.40 186 197095 96747 63194994
Disease complication 25.54 10.40 40 197241 3169 63288572
Loss of consciousness 25.51 10.40 512 196769 117609 63174132
Blood viscosity increased 25.40 10.40 14 197267 274 63291467
Hypoprothrombinaemia 25.26 10.40 14 197267 277 63291464
Skin weeping 25.25 10.40 20 197261 733 63291008
Sedation complication 25.14 10.40 6 197275 13816 63277925
Exostosis 25.13 10.40 12 197269 17850 63273891
Adverse drug reaction 25.08 10.40 145 197136 79569 63212172
Hip fracture 24.92 10.40 167 197114 29307 63262434
Mouth haemorrhage 24.91 10.40 61 197220 6722 63285019
Neoplasm progression 24.89 10.40 47 197234 36381 63255360
Compartment syndrome 24.81 10.40 33 197248 2251 63289490
Cardiomegaly 24.39 10.40 114 197167 17500 63274241
Atrial septal defect repair 24.36 10.40 13 197268 238 63291503
Scleroderma 24.33 10.40 53 197228 5409 63286332
Dry mouth 24.30 10.40 142 197139 77721 63214020
Application site pruritus 24.18 10.40 44 197237 3940 63287801
Right ventricular dysfunction 24.08 10.40 29 197252 1790 63289951
Therapeutic response shortened 24.05 10.40 4 197277 11884 63279857
Haemorrhagic ovarian cyst 24.05 10.40 19 197262 694 63291047
Generalised tonic-clonic seizure 24.00 10.40 33 197248 28983 63262758
Gastric antral vascular ectasia 23.97 10.40 18 197263 609 63291132
Therapy interrupted 23.87 10.40 40 197241 32415 63259326
Infusion site irritation 23.54 10.40 21 197260 909 63290832
Prothrombin time shortened 23.50 10.40 30 197251 1965 63289776
Endarterectomy 23.38 10.40 12 197269 202 63291539
Serotonin syndrome 23.35 10.40 33 197248 28649 63263092
Cardiogenic shock 23.34 10.40 114 197167 17818 63273923
Thyroid haemorrhage 23.23 10.40 9 197272 74 63291667
Prothrombin level abnormal 23.13 10.40 9 197272 75 63291666
Coagulation time shortened 23.11 10.40 11 197270 156 63291585
Cerebral infarction 23.06 10.40 140 197141 23753 63267988
Catheter site dermatitis 23.02 10.40 9 197272 76 63291665
Atrioventricular block complete 23.00 10.40 67 197214 8184 63283557
Foetal exposure during pregnancy 22.95 10.40 40 197241 31922 63259819
No adverse event 22.90 10.40 60 197221 41345 63250396
Sleep disorder due to a general medical condition 22.75 10.40 5 197276 12183 63279558
Catarrh 22.67 10.40 26 197255 1523 63290218
Protein S deficiency 22.46 10.40 7 197274 27 63291714
Subdural haematoma evacuation 22.46 10.40 7 197274 27 63291714
Palmar-plantar erythrodysaesthesia syndrome 22.43 10.40 23 197258 22992 63268749
Renal disorder 22.24 10.40 177 197104 32797 63258944
Pulmonary arterial pressure abnormal 22.22 10.40 16 197265 507 63291234
Catheter site nodule 22.00 10.40 8 197273 54 63291687
Skin exfoliation 21.95 10.40 65 197216 43037 63248704
Concomitant disease progression 21.92 10.40 30 197251 2104 63289637
Cognitive disorder 21.88 10.40 94 197187 55721 63236020
Dry eye 21.84 10.40 60 197221 40701 63251040
Coagulation factor decreased 21.61 10.40 9 197272 91 63291650
Dizziness exertional 21.47 10.40 14 197267 376 63291365
Transient ischaemic attack 21.42 10.40 195 197086 37558 63254183
Sciatica 21.15 10.40 47 197234 34277 63257464
Tendonitis 21.00 10.40 18 197263 19597 63272144
Medical device site thrombosis 20.96 10.40 5 197276 4 63291737
Spinal subarachnoid haemorrhage 20.96 10.40 5 197276 4 63291737
Walking distance test abnormal 20.89 10.40 16 197265 558 63291183
Ovarian rupture 20.85 10.40 7 197274 36 63291705
Deep vein thrombosis postoperative 20.55 10.40 5 197276 11364 63280377
Neuroleptic malignant syndrome 20.48 10.40 6 197275 12050 63279691
Gastrointestinal arteriovenous malformation 20.45 10.40 16 197265 576 63291165
Aortic stenosis 20.44 10.40 47 197234 4973 63286768
Abdominal wall haemorrhage 20.39 10.40 10 197271 152 63291589
Dermatitis atopic 20.29 10.40 3 197278 9721 63282020
Blood culture negative 20.28 10.40 10 197271 154 63291587
Aphthous ulcer 20.17 10.40 9 197272 13929 63277812
Tuberculosis 20.13 10.40 5 197276 11206 63280535
Drug resistance 20.08 10.40 25 197256 22908 63268833
Cardioactive drug level decreased 20.02 10.40 8 197273 72 63291669
Oral mucosa haematoma 19.96 10.40 5 197276 6 63291735
Gait disturbance 19.80 10.40 426 196855 182752 63108989
Conjunctival haemorrhage 19.76 10.40 38 197243 3549 63288192
Stent placement 19.73 10.40 39 197242 3716 63288025
Exercise tolerance decreased 19.72 10.40 49 197232 5448 63286293
Retching 19.70 10.40 94 197187 14551 63277190
Drug eruption 19.63 10.40 37 197244 28657 63263084
Blood pressure increased 19.58 10.40 370 196911 161692 63130049
Mitral valve repair 19.57 10.40 11 197270 224 63291517
Heart valve operation 19.56 10.40 10 197271 167 63291574
Gastrooesophageal reflux disease 19.48 10.40 411 196870 95228 63196513
Nephrosclerosis 19.46 10.40 20 197261 1034 63290707
Balloon atrial septostomy 19.46 10.40 8 197273 78 63291663
Procedural pain 19.43 10.40 23 197258 21546 63270195
Blood pressure fluctuation 19.41 10.40 76 197205 46241 63245500
Autoimmune disorder 19.34 10.40 15 197266 17162 63274579
Endocarditis 19.32 10.40 50 197231 5700 63286041
Infusion site oedema 19.20 10.40 18 197263 831 63290910
Valvuloplasty cardiac 19.11 10.40 4 197277 0 63291741
Tracheal calcification 19.11 10.40 4 197277 0 63291741
Femoral nerve palsy 19.11 10.40 4 197277 0 63291741
Device dislocation 19.02 10.40 141 197140 25564 63266177
Injection site urticaria 18.98 10.40 10 197271 14063 63277678
Cardiac pacemaker replacement 18.85 10.40 13 197268 384 63291357
Aortic dissection 18.69 10.40 27 197254 1991 63289750
Haemophagocytic lymphohistiocytosis 18.59 10.40 5 197276 10622 63281119
Catheter site oedema 18.57 10.40 7 197274 53 63291688
Toxicity to various agents 18.56 10.40 606 196675 246644 63045097
Blue toe syndrome 18.56 10.40 13 197268 394 63291347
Cardiac flutter 18.53 10.40 40 197241 4056 63287685
Dystonia 18.37 10.40 10 197271 13809 63277932
Abdominal cavity drainage 18.27 10.40 13 197268 404 63291337
Prothrombin level increased 18.26 10.40 11 197270 256 63291485
Product storage error 18.23 10.40 12 197269 14944 63276797
Hepatorenal failure 18.22 10.40 16 197265 678 63291063
Device related thrombosis 18.19 10.40 25 197256 1760 63289981
Abortion spontaneous 18.18 10.40 80 197201 47115 63244626
Hepatitis 18.17 10.40 63 197218 39725 63252016
Sinus node dysfunction 18.13 10.40 43 197238 4642 63287099
Injection site rash 18.10 10.40 19 197262 18790 63272951
Joint dislocation 18.08 10.40 19 197262 18781 63272960
Drain placement 18.02 10.40 7 197274 58 63291683
Insomnia 18.01 10.40 520 196761 214732 63077009
Catheter site dryness 18.01 10.40 6 197275 30 63291711
Multiple sclerosis 17.96 10.40 30 197251 24342 63267399
Catheter site urticaria 17.84 10.40 6 197275 31 63291710
Purple glove syndrome 17.82 10.40 10 197271 203 63291538
Mitral valve replacement 17.82 10.40 11 197270 268 63291473
Acne 17.79 10.40 28 197253 23265 63268476
Breast cancer female 17.75 10.40 10 197271 13549 63278192
Hydrocephalus 17.72 10.40 46 197235 5254 63286487
Mitral valve stenosis 17.64 10.40 20 197261 1157 63290584
Liver function test abnormal 17.63 10.40 228 197053 47953 63243788
Drug ineffective for unapproved indication 17.62 10.40 51 197230 34012 63257729
Subarachnoid haematoma 17.52 10.40 5 197276 13 63291728
Blood potassium increased 17.49 10.40 107 197174 18202 63273539
Injection site warmth 17.45 10.40 13 197268 15182 63276559
Renal impairment 17.45 10.40 378 196903 87977 63203764
Eschar 17.44 10.40 15 197266 618 63291123
Device difficult to use 17.39 10.40 9 197272 12787 63278954
Lymphocyte count decreased 17.39 10.40 43 197238 30214 63261527
Contusion 17.37 10.40 599 196682 149445 63142296
Embolic stroke 17.23 10.40 37 197244 3739 63288002
Pulmonary alveolar haemorrhage 17.16 10.40 42 197239 4626 63287115
Cytomegalovirus infection 17.16 10.40 24 197257 20928 63270813
Thoracic haemorrhage 17.10 10.40 6 197275 36 63291705
Thrombectomy 17.10 10.40 9 197272 160 63291581
Panniculitis 17.04 10.40 7 197274 11378 63280363
Chronic cutaneous lupus erythematosus 17.01 10.40 12 197269 368 63291373
Nocturnal dyspnoea 17.00 10.40 20 197261 1204 63290537
Jugular vein distension 16.94 10.40 18 197263 968 63290773
Cor pulmonale 16.90 10.40 26 197255 2028 63289713
Injection site discharge 16.90 10.40 17 197264 857 63290884
Arteriovenous malformation 16.90 10.40 21 197260 1339 63290402
Heart sounds abnormal 16.82 10.40 15 197266 649 63291092
Large intestinal polypectomy 16.78 10.40 10 197271 228 63291513
Skin reaction 16.68 10.40 13 197268 14836 63276905
Obstructive airways disorder 16.66 10.40 24 197257 20675 63271066
Exophthalmos 16.62 10.40 22 197259 1494 63290247
Gestational diabetes 16.60 10.40 3 197278 8393 63283348
Cerebellar haematoma 16.59 10.40 12 197269 383 63291358
Hypophagia 16.50 10.40 159 197122 31100 63260641
Haemorrhagic ascites 16.41 10.40 8 197273 120 63291621
Pneumocystis jirovecii pneumonia 16.37 10.40 17 197264 16897 63274844
Coma scale normal 16.35 10.40 4 197277 4 63291737
Cerebral venous sinus thrombosis 16.28 10.40 25 197256 1947 63289794
Angiodysplasia 16.21 10.40 12 197269 397 63291344
Iron deficiency anaemia 16.20 10.40 112 197169 19857 63271884
Right ventricular enlargement 16.16 10.40 11 197270 318 63291423
Cholecystitis chronic 16.12 10.40 6 197275 10355 63281386
Feeling abnormal 16.09 10.40 588 196693 147804 63143937
Chronic sinusitis 16.07 10.40 10 197271 12833 63278908
Disability 16.06 10.40 20 197261 18327 63273414
Coeliac disease 15.96 10.40 10 197271 12787 63278954
Myocardial infarction 15.95 10.40 415 196866 99478 63192263
Metastases to lymph nodes 15.95 10.40 3 197278 8155 63283586
Duodenal ulcer haemorrhage 15.94 10.40 28 197253 2439 63289302
Carpal tunnel syndrome 15.92 10.40 25 197256 20792 63270949
Device physical property issue 15.90 10.40 25 197256 1987 63289754
Mood swings 15.86 10.40 20 197261 18228 63273513
Blood urea increased 15.86 10.40 138 197143 26241 63265500
Venous thrombosis 15.83 10.40 42 197239 4860 63286881
Aplastic anaemia 15.82 10.40 5 197276 9564 63282177
X-ray abnormal 15.82 10.40 3 197278 8107 63283634
Heavy menstrual bleeding 15.81 10.40 102 197179 17671 63274070
Pulmonary calcification 15.69 10.40 10 197271 258 63291483
Left ventricular failure 15.68 10.40 46 197235 5641 63286100
Ovarian cyst ruptured 15.68 10.40 19 197262 1180 63290561
Inappropriate schedule of product administration 15.63 10.40 228 197053 103737 63188004
Vaginal haematoma 15.57 10.40 8 197273 135 63291606
Dysentery 15.55 10.40 17 197264 944 63290797
Catheter site mass 15.34 10.40 5 197276 23 63291718
Diastolic hypotension 15.32 10.40 7 197274 90 63291651
Urine output decreased 15.31 10.40 73 197208 11297 63280444
Overdose 15.28 10.40 467 196814 114611 63177130
Vascular stenosis 15.26 10.40 11 197270 349 63291392
Splenic haemorrhage 15.23 10.40 9 197272 202 63291539
Disturbance in attention 15.16 10.40 64 197217 38125 63253616
Right ventricular systolic pressure increased 15.15 10.40 13 197268 534 63291207
Multiple injuries 15.13 10.40 23 197258 1775 63289966
Haemorrhagic cerebral infarction 15.13 10.40 14 197267 636 63291105
Chronic respiratory failure 15.12 10.40 24 197257 1923 63289818
Schizophrenia 15.09 10.40 6 197275 9946 63281795
Coagulation factor deficiency 15.08 10.40 4 197277 7 63291734
Parosmia 15.06 10.40 48 197233 6158 63285583
Colitis ulcerative 15.05 10.40 37 197244 26054 63265687
Sickle cell anaemia 15.03 10.40 13 197268 540 63291201
Incorrect route of product administration 15.02 10.40 40 197241 27412 63264329
Tri-iodothyronine increased 15.01 10.40 8 197273 146 63291595
Endotracheal intubation 14.97 10.40 28 197253 2560 63289181
Conjunctivitis 14.95 10.40 26 197255 20770 63270971
Angioplasty 14.95 10.40 20 197261 1372 63290369
Hypercalcaemia 14.94 10.40 42 197239 28280 63263461
Infusion site pruritus 14.94 10.40 47 197234 5988 63285753
Blood creatinine increased 14.93 10.40 368 196913 87476 63204265
White blood cell count decreased 14.88 10.40 324 196957 138780 63152961
Terminal state 14.87 10.40 26 197255 2256 63289485
Anaphylactic shock 14.86 10.40 32 197249 23601 63268140
Lacrimal haemorrhage 14.84 10.40 5 197276 26 63291715
Burns second degree 14.84 10.40 24 197257 1954 63289787
Hypopnoea 14.80 10.40 35 197246 3771 63287970
Blood culture positive 14.72 10.40 40 197241 4695 63287046
Thromboembolectomy 14.69 10.40 5 197276 27 63291714
Implantable defibrillator insertion 14.67 10.40 12 197269 461 63291280
Venous pressure jugular increased 14.55 10.40 13 197268 564 63291177
Mouth ulceration 14.55 10.40 53 197228 32931 63258810
Periorbital haematoma 14.54 10.40 15 197266 779 63290962
Joint effusion 14.52 10.40 19 197262 17041 63274700
Cardiac tamponade 14.51 10.40 40 197241 4735 63287006
Extrasystoles 14.48 10.40 42 197239 5118 63286623
Stress 14.48 10.40 136 197145 67031 63224710
Uterine haemorrhage 14.48 10.40 36 197245 4005 63287736
Metastases to bone 14.47 10.40 27 197254 20992 63270749
Occult blood 14.45 10.40 19 197262 1282 63290459
Diabetic ketoacidosis 14.42 10.40 26 197255 20479 63271262
Colonoscopy 14.37 10.40 21 197260 1565 63290176
Cardiac pacemaker adjustment 14.33 10.40 3 197278 0 63291741
Acquired cardiac septal defect 14.33 10.40 3 197278 0 63291741
Adrenal cortex necrosis 14.33 10.40 3 197278 0 63291741
Iris haemorrhage 14.33 10.40 3 197278 0 63291741
Hepatic artery embolism 14.33 10.40 3 197278 0 63291741
Productive cough 14.32 10.40 276 197005 62932 63228809
Squamous cell carcinoma of the oral cavity 14.31 10.40 10 197271 302 63291439
Blood pressure systolic decreased 14.27 10.40 53 197228 7344 63284397
Abdominal compartment syndrome 14.24 10.40 13 197268 580 63291161
Traumatic intracranial haemorrhage 14.21 10.40 12 197269 482 63291259
Catheter site erosion 14.20 10.40 6 197275 63 63291678
Application site irritation 14.19 10.40 22 197259 1728 63290013
Herpes zoster 14.14 10.40 176 197105 82286 63209455
Oesophageal compression 14.13 10.40 4 197277 10 63291731
Chordae tendinae rupture 14.11 10.40 5 197276 31 63291710
Factor V inhibition 14.01 10.40 8 197273 168 63291573
Rales 13.95 10.40 77 197204 12620 63279121
Brain operation 13.95 10.40 13 197268 596 63291145
Therapeutic product effect increased 13.89 10.40 18 197263 1197 63290544
Prothrombin level decreased 13.84 10.40 13 197268 602 63291139
Clostridium difficile infection 13.78 10.40 148 197133 29774 63261967
Progressive multifocal leukoencephalopathy 13.77 10.40 12 197269 12959 63278782
Lip haemorrhage 13.72 10.40 12 197269 506 63291235
Central nervous system lesion 13.70 10.40 8 197273 10627 63281114
Haematotoxicity 13.66 10.40 6 197275 9370 63282371
Bullous haemorrhagic dermatosis 13.65 10.40 6 197275 70 63291671
Haemorrhagic hepatic cyst 13.60 10.40 5 197276 35 63291706
Live birth 13.53 10.40 38 197243 25592 63266149
Thrombotic microangiopathy 13.53 10.40 8 197273 10553 63281188
Affect lability 13.52 10.40 9 197272 11142 63280599
Emergency care examination 13.42 10.40 6 197275 73 63291668
Oral candidiasis 13.41 10.40 32 197249 22766 63268975
Intervertebral disc protrusion 13.39 10.40 34 197247 23675 63268066
Spinal stenosis 13.35 10.40 16 197265 14909 63276832
Neutropenic sepsis 13.29 10.40 19 197262 16419 63275322
Pulmonary fibrosis 13.29 10.40 71 197210 39738 63252003
Drug-induced liver injury 13.28 10.40 72 197209 40150 63251591
Atrioventricular block 13.28 10.40 53 197228 7594 63284147
Metastases to liver 13.27 10.40 34 197247 23605 63268136
Breast haemorrhage 13.17 10.40 8 197273 189 63291552
Lupus endocarditis 13.16 10.40 9 197272 262 63291479
Purpura 13.15 10.40 70 197211 11315 63280426
Post procedural haematoma 13.10 10.40 18 197263 1267 63290474
Lymphopenia 13.10 10.40 23 197258 18304 63273437
Mental status changes 13.09 10.40 184 197097 39415 63252326
Tricuspid valve incompetence 13.06 10.40 84 197197 14537 63277204
Haematoma infection 13.06 10.40 13 197268 647 63291094
Procedural haemorrhage 13.03 10.40 27 197254 2661 63289080
Catheter site extravasation 12.90 10.40 10 197271 355 63291386
Gastrointestinal toxicity 12.88 10.40 4 197277 7737 63284004
Duodenal ulcer 12.87 10.40 53 197228 7703 63284038
Coagulation time abnormal 12.87 10.40 6 197275 81 63291660
Uveitis 12.86 10.40 12 197269 12541 63279200
Influenza 12.82 10.40 435 196846 108287 63183454
Hepatic infarction 12.73 10.40 13 197268 667 63291074
Nephrogenic systemic fibrosis 12.71 10.40 37 197244 4519 63287222
Steroid dependence 12.69 10.40 21 197260 1743 63289998
Breast cancer 12.68 10.40 93 197188 48290 63243451
Arteriovenous fistula site haemorrhage 12.67 10.40 8 197273 203 63291538
Angioedema 12.67 10.40 92 197189 47873 63243868
Pulmonary artery dilatation 12.64 10.40 9 197272 280 63291461
Body temperature increased 12.60 10.40 66 197215 37126 63254615
Demyelination 12.60 10.40 3 197278 6917 63284824
Incarcerated umbilical hernia 12.53 10.40 4 197277 17 63291724
Pancreatitis 12.52 10.40 95 197186 48960 63242781
Localised oedema 12.51 10.40 41 197240 5337 63286404
Drug withdrawal syndrome 12.46 10.40 43 197238 27151 63264590
Venous haemorrhage 12.42 10.40 9 197272 288 63291453
Pelvic haemorrhage 12.39 10.40 7 197274 144 63291597
Poisoning deliberate 12.37 10.40 10 197271 11208 63280533
Large intestinal haemorrhage 12.37 10.40 18 197263 1336 63290405
Hyphaema 12.37 10.40 9 197272 290 63291451
Blood blister 12.36 10.40 22 197259 1936 63289805
Rehabilitation therapy 12.35 10.40 20 197261 1630 63290111
Subcapsular renal haematoma 12.29 10.40 9 197272 293 63291448
Aggression 12.28 10.40 35 197246 23463 63268278
Infusion site induration 12.28 10.40 17 197264 1205 63290536
Hepatic cytolysis 12.27 10.40 18 197263 15389 63276352
Osteopenia 12.26 10.40 27 197254 19758 63271983
Diet noncompliance 12.25 10.40 10 197271 383 63291358
Weight increased 12.23 10.40 674 196607 260118 63031623
Haemorrhage urinary tract 12.18 10.40 14 197267 822 63290919
Renal stone removal 12.18 10.40 7 197274 149 63291592
Acute generalised exanthematous pustulosis 12.11 10.40 10 197271 11089 63280652
Pyelonephritis 12.09 10.40 23 197258 17755 63273986
Creatinine renal clearance decreased 12.08 10.40 20 197261 16288 63275453
Biopsy liver 12.07 10.40 10 197271 391 63291350
Cardiac output decreased 12.06 10.40 15 197266 957 63290784
Brachiocephalic vein thrombosis 12.02 10.40 6 197275 95 63291646
Cardiac resynchronisation therapy 12.00 10.40 4 197277 20 63291721
Infected skin ulcer 11.99 10.40 24 197257 2308 63289433
Paraplegia 11.98 10.40 26 197255 2646 63289095
Dermatomyositis 11.97 10.40 27 197254 2821 63288920
Oxygen consumption 11.91 10.40 6 197275 97 63291644
Bronchopulmonary aspergillosis 11.85 10.40 6 197275 8629 63283112
Upper respiratory tract inflammation 11.83 10.40 25 197256 2498 63289243
Arteriovenous fistula operation 11.82 10.40 8 197273 229 63291512
Liver function test increased 11.82 10.40 57 197224 32754 63258987
Skin discolouration 11.80 10.40 174 197107 37654 63254087
Thyroiditis acute 11.80 10.40 6 197275 99 63291642
Injection site pustule 11.80 10.40 6 197275 99 63291642
Diverticulum intestinal haemorrhagic 11.79 10.40 19 197262 1542 63290199
Aspiration pleural cavity 11.77 10.40 14 197267 853 63290888
Ear infection 11.76 10.40 70 197211 38143 63253598
Shock 11.73 10.40 118 197163 23345 63268396
Low cardiac output syndrome 11.65 10.40 10 197271 411 63291330
Myocarditis 11.65 10.40 9 197272 10316 63281425
Premature labour 11.62 10.40 13 197268 12491 63279250
Spinal cord haemorrhage 11.61 10.40 8 197273 236 63291505
Nail disorder 11.59 10.40 14 197267 13001 63278740
Transaminases increased 11.58 10.40 54 197227 31313 63260428
Mitral valve incompetence 11.52 10.40 102 197179 19492 63272249
Peripheral embolism 11.52 10.40 17 197264 1278 63290463
Pulmonary arterial wedge pressure increased 11.50 10.40 9 197272 324 63291417
Investigation 11.40 10.40 19 197262 1586 63290155
Product administration error 11.37 10.40 113 197168 22284 63269457
Heart transplant 11.36 10.40 11 197270 529 63291212
Extremity necrosis 11.33 10.40 19 197262 1594 63290147
Pharyngeal haematoma 11.25 10.40 5 197276 60 63291681
Neuropathy peripheral 11.24 10.40 268 197013 113399 63178342
Concomitant disease aggravated 11.20 10.40 57 197224 9055 63282686
Catheter site hypersensitivity 11.19 10.40 6 197275 111 63291630
Transaminases abnormal 11.16 10.40 12 197269 654 63291087
Disease recurrence 11.11 10.40 47 197234 27983 63263758
Hyponatraemic syndrome 11.11 10.40 11 197270 544 63291197
Heart valve incompetence 11.08 10.40 26 197255 2788 63288953
Craniectomy 11.05 10.40 3 197278 6 63291735
Iliac artery embolism 11.05 10.40 3 197278 6 63291735
Finger amputation 11.04 10.40 11 197270 548 63291193
Hypomania 11.03 10.40 3 197278 6327 63285414
Aortic surgery 11.00 10.40 4 197277 27 63291714
Pulmonary resection 11.00 10.40 4 197277 27 63291714
Right atrial dilatation 11.00 10.40 12 197269 665 63291076
Status epilepticus 10.99 10.40 19 197262 15214 63276527
Poor peripheral circulation 10.99 10.40 31 197250 3718 63288023
Inadequate diet 10.97 10.40 7 197274 181 63291560
Migraine 10.97 10.40 241 197040 103105 63188636
Somnolence 10.97 10.40 669 196612 178016 63113725
Hernia obstructive 10.95 10.40 6 197275 116 63291625
Gravitational oedema 10.89 10.40 16 197265 1198 63290543
Pathological fracture 10.89 10.40 7 197274 8827 63282914
Heart rate abnormal 10.87 10.40 37 197244 4910 63286831
Maternal exposure before pregnancy 10.86 10.40 5 197276 7598 63284143
Dermatitis allergic 10.84 10.40 19 197262 15129 63276612
N-terminal prohormone brain natriuretic peptide increased 10.82 10.40 22 197259 2139 63289602
Renal haemorrhage 10.82 10.40 14 197267 930 63290811
Mallory-Weiss syndrome 10.80 10.40 18 197263 1503 63290238
Chronic obstructive pulmonary disease 10.76 10.40 263 197018 62423 63229318
Metastases to central nervous system 10.74 10.40 15 197266 13090 63278651
Encephalopathy 10.72 10.40 73 197208 38547 63253194
Polyneuropathy 10.71 10.40 18 197263 14571 63277170
Hepatic haematoma 10.65 10.40 10 197271 463 63291278
Cardiac function disturbance postoperative 10.64 10.40 4 197277 30 63291711
Blood pressure systolic increased 10.63 10.40 95 197186 47302 63244439
Colon operation 10.63 10.40 9 197272 363 63291378
Incision site haemorrhage 10.62 10.40 11 197270 574 63291167
Vessel puncture site haemorrhage 10.59 10.40 6 197275 124 63291617
Subchorionic haematoma 10.55 10.40 6 197275 125 63291616
Suture insertion 10.54 10.40 8 197273 275 63291466
Device malfunction 10.52 10.40 93 197188 17764 63273977
Paracentesis 10.52 10.40 14 197267 956 63290785
Unintentional medical device removal 10.46 10.40 3 197278 6112 63285629
Cerebral artery thrombosis 10.46 10.40 9 197272 371 63291370
Maxillonasal dysplasia 10.46 10.40 3 197278 8 63291733
Skin fissures 10.41 10.40 12 197269 11376 63280365

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 11187.21 10.73 5190 168106 42137 34741498
Gastric haemorrhage 2029.01 10.73 999 172297 9262 34774373
Haemorrhage 1965.97 10.73 1792 171504 49578 34734057
International normalised ratio abnormal 1809.54 10.73 665 172631 2670 34780965
International normalised ratio decreased 1205.73 10.73 543 172753 4024 34779611
Gastrointestinal haemorrhage 1070.93 10.73 1718 171578 86759 34696876
Anticoagulation drug level above therapeutic 1027.43 10.73 389 172907 1727 34781908
Drug interaction 849.65 10.73 2752 170544 223194 34560441
Haematuria 736.31 10.73 1065 172231 49001 34734634
Subdural haematoma 734.59 10.73 689 172607 19732 34763903
Haematoma 715.70 10.73 753 172543 24852 34758783
Melaena 619.71 10.73 819 172477 34561 34749074
Haemorrhage intracranial 606.33 10.73 555 172741 15391 34768244
Epistaxis 528.61 10.73 997 172299 57254 34726381
Anticoagulation drug level below therapeutic 507.68 10.73 183 173113 685 34782950
International normalised ratio fluctuation 459.77 10.73 189 173107 1085 34782550
Calciphylaxis 424.92 10.73 171 173125 921 34782714
Haemoglobin decreased 353.74 10.73 1357 171939 119415 34664220
Febrile neutropenia 353.19 10.73 119 173177 136730 34646905
Rectal haemorrhage 349.06 10.73 676 172620 39573 34744062
Labelled drug-drug interaction medication error 345.64 10.73 398 172898 14541 34769094
Cerebral haemorrhage 336.82 10.73 614 172682 34323 34749312
Prothrombin time prolonged 324.08 10.73 310 172986 9096 34774539
Anaemia 323.76 10.73 2120 171176 231215 34552420
Off label use 322.85 10.73 1039 172257 418485 34365150
Drug ineffective 280.69 10.73 1240 172056 455511 34328124
Haemoptysis 258.38 10.73 550 172746 34456 34749179
Cardiac failure congestive 256.29 10.73 951 172345 82319 34701316
Coagulopathy 247.99 10.73 391 172905 19398 34764237
Drug abuse 247.29 10.73 91 173205 99005 34684630
Fall 242.48 10.73 1778 171518 201107 34582528
Muscle haemorrhage 241.89 10.73 177 173119 3541 34780094
Pyrexia 239.16 10.73 849 172447 332164 34451471
Cardiac failure 208.71 10.73 951 172345 90297 34693338
Upper gastrointestinal haemorrhage 204.77 10.73 415 172881 25103 34758532
Faeces discoloured 203.29 10.73 306 172990 14572 34769063
Abdominal wall haematoma 193.42 10.73 118 173178 1719 34781916
Subarachnoid haemorrhage 185.79 10.73 269 173027 12366 34771269
Neutropenia 184.76 10.73 308 172988 156470 34627165
Retroperitoneal haematoma 184.50 10.73 132 173164 2546 34781089
Pulmonary arterial hypertension 164.87 10.73 210 173086 8529 34775106
Haematocrit decreased 164.83 10.73 439 172857 31777 34751858
Contusion 163.79 10.73 473 172823 35891 34747744
Ecchymosis 160.29 10.73 183 173113 6620 34777015
Subdural haemorrhage 157.58 10.73 129 173167 3062 34780573
Retroperitoneal haemorrhage 149.47 10.73 120 173176 2768 34780867
Fluid retention 139.17 10.73 368 172928 26519 34757116
Haematemesis 137.11 10.73 373 172923 27338 34756297
Coagulation time prolonged 135.46 10.73 83 173213 1219 34782416
Foetal warfarin syndrome 133.67 10.73 31 173265 0 34783635
Product use in unapproved indication 131.81 10.73 238 173058 117261 34666374
Atrial fibrillation 126.09 10.73 1037 172259 121356 34662279
COVID-19 118.08 10.73 126 173170 77424 34706211
Intra-abdominal haematoma 111.94 10.73 75 173221 1295 34782340
Haemarthrosis 111.47 10.73 107 173189 3152 34780483
Right ventricular failure 109.24 10.73 173 173123 8611 34775024
Depression 108.59 10.73 197 173099 96901 34686734
Intraventricular haemorrhage 102.43 10.73 106 173190 3425 34780210
Thrombosis 102.23 10.73 508 172788 49950 34733685
Pulmonary hypertension 101.86 10.73 280 173016 20644 34762991
Lower gastrointestinal haemorrhage 99.87 10.73 173 173123 9279 34774356
Mucosal inflammation 98.77 10.73 34 173262 38588 34745047
Haematoma muscle 97.86 10.73 69 173227 1299 34782336
Head injury 95.44 10.73 250 173046 17910 34765725
Dyspnoea 93.97 10.73 2487 170809 374295 34409340
Occult blood positive 93.86 10.73 108 173188 3940 34779695
Transfusion 93.16 10.73 159 173137 8426 34775209
Cytokine release syndrome 92.84 10.73 5 173291 22872 34760763
Malignant neoplasm progression 89.47 10.73 189 173107 87857 34695778
Intentional overdose 87.60 10.73 54 173242 43620 34740015
Shock haemorrhagic 85.58 10.73 180 173116 11174 34772461
Infusion related reaction 85.55 10.73 82 173214 52975 34730660
Anticoagulant-related nephropathy 85.07 10.73 24 173272 28 34783607
Blood loss anaemia 84.01 10.73 148 173148 8046 34775589
Ear haemorrhage 83.43 10.73 55 173241 923 34782712
Deep vein thrombosis 82.34 10.73 580 172716 64668 34718967
Cerebral mass effect 80.76 10.73 54 173242 929 34782706
Appendicolith 80.10 10.73 149 173147 8452 34775183
Suicide attempt 78.96 10.73 48 173248 39068 34744567
Activated partial thromboplastin time prolonged 78.94 10.73 149 173147 8546 34775089
Spinal epidural haematoma 78.09 10.73 36 173260 283 34783352
Gingival bleeding 77.75 10.73 131 173165 6869 34776766
Leukopenia 77.20 10.73 120 173176 62736 34720899
Intestinal haematoma 75.73 10.73 26 173270 81 34783554
Therapeutic product effect incomplete 74.83 10.73 84 173212 50457 34733178
Completed suicide 74.37 10.73 244 173052 97924 34685711
Anaphylactic reaction 71.95 10.73 35 173261 32266 34751369
Cerebrovascular accident 71.48 10.73 688 172608 84123 34699512
Agitation 71.05 10.73 109 173187 57290 34726345
Pain in jaw 70.04 10.73 181 173115 12859 34770776
Pulmonary alveolar haemorrhage 69.78 10.73 130 173166 7382 34776253
Drug dependence 67.93 10.73 18 173278 24199 34759436
Prothrombin time ratio increased 67.45 10.73 27 173269 143 34783492
Foetal exposure during pregnancy 67.32 10.73 54 173242 38047 34745588
Cardiac tamponade 67.26 10.73 105 173191 5161 34778474
Pancytopenia 67.03 10.73 244 173052 94913 34688722
Product use issue 66.49 10.73 133 173163 63083 34720552
Oedema peripheral 64.95 10.73 892 172404 118920 34664715
Extradural haematoma 64.95 10.73 51 173245 1138 34782497
Ventricular tachycardia 64.40 10.73 282 173014 26297 34757338
Dizziness 64.31 10.73 1476 171820 217045 34566590
Arthralgia 63.64 10.73 538 172758 169503 34614132
Oedema 63.29 10.73 416 172880 45325 34738310
Haemorrhage subcutaneous 62.49 10.73 67 173229 2257 34781378
Intentional product use issue 61.08 10.73 128 173168 59688 34723947
Thrombocytopenia 60.44 10.73 490 172806 155757 34627878
Skin necrosis 60.37 10.73 106 173190 5747 34777888
Heparin-induced thrombocytopenia 59.89 10.73 103 173193 5492 34778143
Cardiogenic shock 59.69 10.73 276 173020 26342 34757293
Neutrophil count decreased 59.53 10.73 101 173195 51003 34732632
Disease progression 57.97 10.73 307 172989 107770 34675865
Post procedural haemorrhage 57.42 10.73 127 173169 8162 34775473
Stomatitis 57.29 10.73 76 173220 42438 34741197
Conjunctival haemorrhage 56.97 10.73 73 173223 2982 34780653
Haemorrhagic stroke 56.83 10.73 110 173186 6429 34777206
Toxicity to various agents 55.90 10.73 680 172616 199682 34583953
Asthma 55.72 10.73 78 173218 42578 34741057
Seizure 55.60 10.73 299 172997 104558 34679077
Compartment syndrome 54.53 10.73 71 173225 2947 34780688
Synovitis 54.31 10.73 4 173292 14062 34769573
Rheumatoid arthritis 53.97 10.73 66 173230 38172 34745463
Hepatic cytolysis 53.55 10.73 5 173291 14491 34769144
Hypervolaemia 53.10 10.73 216 173080 19493 34764142
Traumatic haematoma 52.91 10.73 37 173259 687 34782948
Cytomegalovirus infection 52.84 10.73 32 173264 26103 34757532
Myelosuppression 52.76 10.73 15 173281 19250 34764385
Acute myeloid leukaemia 52.35 10.73 13 173283 18257 34765378
Pain 52.15 10.73 708 172588 203967 34579668
Drug hypersensitivity 51.88 10.73 214 173082 80315 34703320
Atrial flutter 51.31 10.73 182 173114 15392 34768243
Gastritis erosive 50.60 10.73 99 173197 5833 34777802
Transient ischaemic attack 49.66 10.73 269 173027 27344 34756291
Rash 49.65 10.73 791 172505 221961 34561674
Device alarm issue 49.62 10.73 34 173262 610 34783025
Aggression 49.17 10.73 73 173223 38891 34744744
Suicidal ideation 48.73 10.73 78 173218 40310 34743325
Haemoperitoneum 48.30 10.73 52 173244 1760 34781875
Scrotal haematoma 48.24 10.73 18 173278 76 34783559
Colitis 47.37 10.73 71 173225 37679 34745956
Cardiac failure chronic 47.18 10.73 114 173182 7765 34775870
Ventricular fibrillation 47.10 10.73 232 173064 22722 34760913
Cerebellar haemorrhage 47.09 10.73 48 173248 1523 34782112
Rash maculo-papular 46.99 10.73 43 173253 28408 34755227
Cholestasis 46.60 10.73 39 173257 26909 34756726
Chills 46.41 10.73 225 173071 80818 34702817
Dyspnoea exertional 46.25 10.73 370 172926 42909 34740726
Catheter site erythema 45.98 10.73 45 173251 1358 34782277
White blood cell count decreased 45.84 10.73 281 173015 95164 34688471
Gastric ulcer 45.78 10.73 176 173120 15474 34768161
Prostate cancer 45.59 10.73 79 173217 39570 34744065
Spontaneous haematoma 45.58 10.73 30 173266 502 34783133
Device interaction 45.49 10.73 31 173265 551 34783084
Angioedema 45.26 10.73 72 173224 37302 34746333
Gastrointestinal arteriovenous malformation 45.04 10.73 26 173270 340 34783295
Mesenteric haematoma 44.85 10.73 13 173283 18 34783617
Lymphopenia 44.21 10.73 13 173283 16322 34767313
Haematochezia 43.98 10.73 387 172909 46147 34737488
Gastric ulcer haemorrhage 43.95 10.73 89 173207 5377 34778258
Appendicitis 43.71 10.73 167 173129 14640 34768995
Catheter management 43.48 10.73 37 173259 928 34782707
Subcutaneous haematoma 42.36 10.73 37 173259 962 34782673
Intentional product misuse 42.17 10.73 103 173193 45508 34738127
Urticaria 41.92 10.73 163 173133 62214 34721421
Anxiety 41.61 10.73 305 172991 99123 34684512
Mallory-Weiss syndrome 40.96 10.73 42 173254 1342 34782293
Hyphaema 40.59 10.73 29 173267 558 34783077
Cardiac failure acute 40.54 10.73 130 173166 10440 34773195
Hypotension 40.44 10.73 1409 171887 220240 34563395
Chest wall haematoma 40.33 10.73 20 173276 188 34783447
Neoplasm progression 39.95 10.73 34 173262 23266 34760369
Psoriasis 39.66 10.73 83 173213 38729 34744906
General physical health deterioration 39.37 10.73 426 172870 127843 34655792
Thrombosis in device 39.31 10.73 64 173232 3261 34780374
Hyperhidrosis 38.92 10.73 218 173078 75474 34708161
Pruritus 38.74 10.73 484 172812 141497 34642138
Generalised tonic-clonic seizure 38.68 10.73 29 173267 21145 34762490
Injection site pain 38.53 10.73 85 173211 38920 34744715
International normalised ratio 37.98 10.73 13 173283 40 34783595
Renal haemorrhage 37.42 10.73 41 173255 1416 34782219
Mouth haemorrhage 37.41 10.73 82 173214 5237 34778398
Hepatocellular injury 37.36 10.73 33 173263 22178 34761457
Psychotic disorder 36.89 10.73 40 173256 24412 34759223
Penile necrosis 36.62 10.73 13 173283 46 34783589
Prothrombin time abnormal 36.43 10.73 30 173266 718 34782917
Disturbance in attention 36.38 10.73 45 173251 25900 34757735
Alanine aminotransferase increased 36.21 10.73 243 173053 80572 34703063
Hypertension 36.16 10.73 468 172828 135975 34647660
Haematoma evacuation 36.14 10.73 18 173278 171 34783464
Hypercoagulation 35.68 10.73 38 173258 1270 34782365
Bronchopulmonary aspergillosis 35.62 10.73 14 173282 14645 34768990
Pancreatitis acute 35.23 10.73 53 173243 28088 34755547
Diabetic ketoacidosis 35.18 10.73 23 173273 18009 34765626
Catheter site haemorrhage 35.12 10.73 49 173247 2175 34781460
Pancreatitis 35.03 10.73 89 173207 38802 34744833
Syncope 34.82 10.73 642 172654 90809 34692826
Musculoskeletal stiffness 34.65 10.73 117 173179 46563 34737072
Venous pressure jugular increased 34.64 10.73 30 173266 771 34782864
Thalamus haemorrhage 34.38 10.73 33 173263 972 34782663
Diverticulum intestinal haemorrhagic 34.31 10.73 52 173244 2490 34781145
Lymphadenopathy 34.31 10.73 55 173241 28408 34755227
Serotonin syndrome 34.28 10.73 29 173267 19904 34763731
Therapeutic product effect decreased 34.08 10.73 76 173220 34667 34748968
Infection 33.80 10.73 288 173008 90627 34693008
Blood phosphorus increased 33.37 10.73 99 173197 7622 34776013
Exposure during pregnancy 33.22 10.73 3 173293 8931 34774704
Accidental exposure to product 33.19 10.73 11 173285 12791 34770844
Blood pressure fluctuation 33.14 10.73 46 173250 25203 34758432
Product dose omission issue 33.06 10.73 407 172889 119304 34664331
Implant site haematoma 32.61 10.73 13 173283 68 34783567
Psoriatic arthropathy 32.60 10.73 30 173266 19768 34763867
Drug intolerance 32.60 10.73 168 173128 59402 34724233
Insomnia 32.31 10.73 344 172952 103563 34680072
Sinusitis 31.96 10.73 102 173194 41300 34742335
Extrapyramidal disorder 31.80 10.73 12 173284 12868 34770767
Catheter site discharge 31.76 10.73 26 173270 617 34783018
Tumour lysis syndrome 31.63 10.73 23 173273 17036 34766599
Therapy partial responder 31.40 10.73 5 173291 9611 34774024
Drug ineffective for unapproved indication 31.33 10.73 43 173253 23672 34759963
Pericardial haemorrhage 31.03 10.73 56 173240 3102 34780533
Restlessness 30.94 10.73 49 173247 25433 34758202
Oxygen consumption increased 30.92 10.73 36 173260 1330 34782305
Intracardiac thrombus 30.81 10.73 49 173247 2447 34781188
Treatment failure 30.75 10.73 123 173173 46574 34737061
Haemorrhagic diathesis 30.35 10.73 52 173244 2764 34780871
Internal haemorrhage 30.25 10.73 73 173223 4968 34778667
Blood urine present 30.19 10.73 120 173176 10714 34772921
Food interaction 30.18 10.73 30 173266 923 34782712
Small intestinal haemorrhage 29.74 10.73 44 173252 2062 34781573
Pelvic haematoma 29.49 10.73 16 173280 184 34783451
Atrial thrombosis 29.47 10.73 45 173251 2169 34781466
Abnormal behaviour 29.39 10.73 49 173247 24920 34758715
Aspergillus infection 29.29 10.73 12 173284 12242 34771393
Traumatic intracranial haemorrhage 29.26 10.73 26 173270 692 34782943
Cardiac pacemaker insertion 29.26 10.73 52 173244 2846 34780789
Duodenal ulcer 29.24 10.73 115 173181 10217 34773418
Lymphocyte count decreased 28.91 10.73 42 173254 22580 34761055
COVID-19 pneumonia 28.79 10.73 25 173271 16942 34766693
Bone marrow failure 28.69 10.73 64 173232 29189 34754446
Posterior reversible encephalopathy syndrome 28.68 10.73 7 173289 9947 34773688
Mediastinal haematoma 28.55 10.73 13 173283 99 34783536
Choroidal haemorrhage 28.48 10.73 12 173284 74 34783561
Abdominal distension 28.28 10.73 427 172869 58065 34725570
Hypokalaemia 28.14 10.73 171 173125 58043 34725592
Multiple sclerosis relapse 28.09 10.73 15 173281 13118 34770517
Adrenal haemorrhage 27.73 10.73 16 173280 209 34783426
Aplastic anaemia 27.67 10.73 7 173289 9709 34773926
Premature baby 27.58 10.73 34 173262 19599 34764036
Blue toe syndrome 27.49 10.73 14 173282 140 34783495
Gamma-glutamyltransferase increased 27.02 10.73 66 173230 29165 34754470
Cardioversion 27.00 10.73 28 173268 907 34782728
Cerebral haematoma 26.81 10.73 66 173230 4549 34779086
Irritability 26.77 10.73 51 173245 24639 34758996
Arteriovenous malformation 26.69 10.73 26 173270 780 34782855
Haemothorax 26.66 10.73 59 173237 3793 34779842
Pneumonitis 26.47 10.73 83 173213 33795 34749840
Asthenia 26.44 10.73 1477 171819 243774 34539861
Hepatotoxicity 26.38 10.73 41 173255 21444 34762191
Neuroleptic malignant syndrome 26.33 10.73 30 173266 17904 34765731
Hypertriglyceridaemia 26.26 10.73 5 173291 8443 34775192
Hyperbilirubinaemia 26.02 10.73 27 173269 16816 34766819
Neutrophil count increased 25.92 10.73 28 173268 17118 34766517
Pneumocystis jirovecii pneumonia 25.78 10.73 36 173260 19674 34763961
Pulmonary embolism 25.63 10.73 604 172692 89142 34694493
Epilepsy 25.47 10.73 42 173254 21453 34762182
Coma 25.45 10.73 128 173168 45550 34738085
Duodenal ulcer haemorrhage 25.31 10.73 68 173228 4945 34778690
Drug resistance 25.20 10.73 57 173239 25870 34757765
C-reactive protein increased 25.07 10.73 161 173135 53937 34729698
Sedation 24.93 10.73 41 173255 20965 34762670
Colonic haematoma 24.90 10.73 9 173287 34 34783601
Substance abuse 24.89 10.73 4 173292 7637 34775998
Hypochromasia 24.86 10.73 17 173279 304 34783331
Coagulation time shortened 24.85 10.73 15 173281 214 34783421
Steroid dependence 24.82 10.73 34 173262 1483 34782152
Product administration error 24.67 10.73 152 173144 16192 34767443
Cerebral artery embolism 24.58 10.73 26 173270 862 34782773
Hepatic steatosis 24.55 10.73 33 173263 18329 34765306
Anticoagulation drug level decreased 24.55 10.73 12 173284 109 34783526
Blood pressure increased 24.51 10.73 299 172997 87803 34695832
Sleep disorder 24.50 10.73 78 173218 31610 34752025
Sopor 24.42 10.73 122 173174 12014 34771621
Oesophageal carcinoma 24.11 10.73 8 173288 9296 34774339
Catheter site pruritus 24.07 10.73 17 173279 321 34783314
Joint swelling 23.95 10.73 186 173110 59704 34723931
Septic shock 23.89 10.73 234 173062 71600 34712035
Diverticulum 23.87 10.73 84 173212 7075 34776560
Tremor 23.85 10.73 278 173018 82309 34701326
Medical device site thrombosis 23.77 10.73 8 173288 23 34783612
Dyskinesia 23.69 10.73 47 173249 22366 34761269
Immune reconstitution inflammatory syndrome 23.65 10.73 7 173289 8752 34774883
Therapeutic product effect increased 23.61 10.73 23 173273 690 34782945
Spinal subdural haematoma 23.55 10.73 10 173286 63 34783572
Hallucination, auditory 23.52 10.73 15 173281 11902 34771733
Sinus tachycardia 23.42 10.73 31 173265 17329 34766306
Haemophagocytic lymphohistiocytosis 23.40 10.73 18 173278 12955 34770680
Hepatic enzyme increased 23.24 10.73 107 173189 38973 34744662
Hypocoagulable state 23.22 10.73 26 173270 920 34782715
Complication associated with device 23.15 10.73 74 173222 5932 34777703
Cardiac operation 23.11 10.73 49 173247 3058 34780577
Death 23.05 10.73 1681 171615 396368 34387267
Neuropathy peripheral 23.00 10.73 283 173013 82980 34700655
Laryngeal haematoma 22.92 10.73 13 173283 164 34783471
Hypersensitivity 22.83 10.73 193 173103 60842 34722793
Subarachnoid haematoma 22.74 10.73 15 173281 252 34783383
Depressed mood 22.65 10.73 38 173258 19279 34764356
Potentiating drug interaction 22.64 10.73 65 173231 4912 34778723
Lung transplant 22.64 10.73 38 173258 1986 34781649
Medical device change 22.58 10.73 12 173284 132 34783503
Intraocular haematoma 22.56 10.73 7 173289 14 34783621
Haemorrhoidal haemorrhage 22.55 10.73 54 173242 3657 34779978
Intentional self-injury 22.52 10.73 21 173275 13750 34769885
Alopecia 22.50 10.73 55 173241 24300 34759335
Inflammation 22.33 10.73 69 173227 28226 34755409
Dystonia 22.31 10.73 13 173283 10832 34772803
Product complaint 22.19 10.73 72 173224 5818 34777817
Antiphospholipid syndrome 22.14 10.73 19 173277 482 34783153
Atheroembolism 22.12 10.73 16 173280 314 34783321
Embolic stroke 22.06 10.73 60 173236 4394 34779241
Anger 22.06 10.73 16 173280 11868 34771767
Nephropathy 21.99 10.73 72 173224 5845 34777790
Haemorrhagic arteriovenous malformation 21.89 10.73 17 173279 373 34783262
Fat embolism 21.88 10.73 13 173283 180 34783455
Hyperthyroidism 21.82 10.73 107 173189 10459 34773176
Purpura 21.71 10.73 105 173191 10206 34773429
Obstructive airways disorder 21.59 10.73 27 173269 15467 34768168
Schizophrenia 21.52 10.73 8 173288 8658 34774977
Catheter placement 21.44 10.73 23 173273 775 34782860
Paranoia 21.44 10.73 17 173279 12051 34771584
Paraesthesia 21.36 10.73 209 173087 63963 34719672
Aspartate aminotransferase increased 21.22 10.73 224 173072 67559 34716076
Peripheral swelling 21.20 10.73 513 172783 76028 34707607
Muscle strain 21.15 10.73 55 173241 3921 34779714
Acute generalised exanthematous pustulosis 21.08 10.73 4 173292 6772 34776863
Akathisia 20.97 10.73 7 173289 8102 34775533
Haemorrhagic cholecystitis 20.93 10.73 10 173286 86 34783549
Anticoagulation drug level increased 20.91 10.73 19 173277 521 34783114
Mental status changes 20.78 10.73 284 173012 37799 34745836
Labelled drug-disease interaction medication error 20.78 10.73 11 173285 120 34783515
Hyperkalaemia 20.73 10.73 470 172826 68919 34714716
Apallic syndrome 20.68 10.73 14 173282 246 34783389
Congestive hepatopathy 20.62 10.73 35 173261 1846 34781789
Psychomotor hyperactivity 20.57 10.73 11 173285 9611 34774024
Herpes zoster 20.56 10.73 94 173202 34305 34749330
Hepatitis 20.54 10.73 56 173240 23848 34759787
Catheter site pain 20.42 10.73 29 173267 1309 34782326
Withdrawal syndrome 20.36 10.73 19 173277 12436 34771199
Intra-abdominal haemorrhage 20.35 10.73 40 173256 2364 34781271
Hepatic failure 20.26 10.73 95 173201 34436 34749199
Blood viscosity decreased 20.17 10.73 9 173287 65 34783570
Adrenal insufficiency 20.08 10.73 24 173272 14023 34769612
Hypoprothrombinaemia 20.04 10.73 16 173280 366 34783269
Cytomegalovirus viraemia 19.95 10.73 6 173290 7424 34776211
Large intestinal haemorrhage 19.92 10.73 32 173264 1612 34782023
Brain herniation 19.86 10.73 54 173242 3954 34779681
Prothrombin time shortened 19.83 10.73 30 173266 1434 34782201
Platelet distribution width increased 19.80 10.73 11 173285 133 34783502
Drug withdrawal syndrome 19.77 10.73 43 173253 19791 34763844
Splenic haematoma 19.66 10.73 12 173284 175 34783460
Pericarditis uraemic 19.34 10.73 6 173290 12 34783623
Encephalitis 19.32 10.73 6 173290 7271 34776364
Renal haematoma 19.30 10.73 18 173278 511 34783124
Wheezing 19.29 10.73 123 173173 41279 34742356
Pulmonary endarterectomy 19.18 10.73 9 173287 74 34783561
Mitral valve replacement 19.08 10.73 12 173284 185 34783450
Protein S deficiency 19.05 10.73 10 173286 107 34783528
Gravitational oedema 18.98 10.73 20 173276 660 34782975
Rash erythematous 18.95 10.73 62 173234 24915 34758720
Central venous catheterisation 18.94 10.73 28 173268 1311 34782324
Neurotoxicity 18.83 10.73 38 173258 17972 34765663
No adverse event 18.75 10.73 55 173241 22872 34760763
Anastomotic infection 18.74 10.73 10 173286 111 34783524
Pathogen resistance 18.63 10.73 12 173284 9470 34774165
Illness 18.41 10.73 24 173272 13505 34770130
Obesity 18.41 10.73 22 173274 12856 34770779
Drug-induced liver injury 18.32 10.73 77 173219 28755 34754880
Cardiotoxicity 18.30 10.73 3 173293 5645 34777990
Prothrombin level abnormal 18.30 10.73 9 173287 83 34783552
Large intestinal ulcer haemorrhage 18.28 10.73 10 173286 117 34783518
Rales 18.25 10.73 97 173199 9786 34773849
Ventricular hyperkinesia 18.07 10.73 12 173284 204 34783431
Transplant evaluation 18.04 10.73 17 173279 489 34783146
Catheter removal 18.02 10.73 12 173284 205 34783430
Medication error 17.99 10.73 200 173096 25365 34758270
Nausea 17.99 10.73 1446 171850 338462 34445173
Diffuse large B-cell lymphoma 17.97 10.73 7 173289 7363 34776272
Vitamin K deficiency 17.89 10.73 13 173283 257 34783378
Anal abscess 17.80 10.73 5 173291 6468 34777167
Transplant rejection 17.73 10.73 15 173281 10296 34773339
Stress 17.67 10.73 229 173067 30118 34753517
Hepatitis B 17.65 10.73 4 173292 5979 34777656
Tongue haematoma 17.64 10.73 10 173286 126 34783509
Prothrombin level increased 17.64 10.73 11 173285 167 34783468
Drug reaction with eosinophilia and systemic symptoms 17.55 10.73 94 173202 32918 34750717
Fistula 17.52 10.73 6 173290 6834 34776801
Pharyngeal haematoma 17.45 10.73 8 173288 62 34783573
Influenza like illness 17.43 10.73 74 173222 27560 34756075
Hemianopia homonymous 17.39 10.73 20 173276 729 34782906
Heart valve replacement 17.34 10.73 15 173281 385 34783250
Somnolence 17.27 10.73 419 172877 110697 34672938
Tracheal calcification 17.25 10.73 4 173292 0 34783635
Gangrene 17.22 10.73 56 173240 4530 34779105
Haemobilia 17.21 10.73 15 173281 389 34783246
Fear 17.10 10.73 16 173280 10460 34773175
Palmar-plantar erythrodysaesthesia syndrome 17.08 10.73 36 173260 16759 34766876
Hyperglycaemia 17.03 10.73 120 173176 39360 34744275
Chest tube insertion 17.01 10.73 9 173287 98 34783537
Blood pressure decreased 17.00 10.73 354 172942 51161 34732474
Pneumonia fungal 16.89 10.73 7 173289 7093 34776542
Bovine tuberculosis 16.86 10.73 9 173287 100 34783535
Injection site reaction 16.85 10.73 24 173272 13009 34770626
Encephalomalacia 16.79 10.73 21 173275 837 34782798
Right ventricular diastolic collapse 16.72 10.73 8 173288 69 34783566
Poisoning deliberate 16.72 10.73 9 173287 7835 34775800
Dry skin 16.68 10.73 89 173207 31198 34752437
Vomiting 16.59 10.73 1032 172264 246589 34537046
Adenovirus infection 16.58 10.73 3 173293 5254 34778381
Blood cholinesterase decreased 16.55 10.73 10 173286 143 34783492
Exercise tolerance decreased 16.48 10.73 60 173236 5138 34778497
Xanthopsia 16.43 10.73 10 173286 145 34783490
Sleep disorder due to a general medical condition 16.42 10.73 3 173293 5218 34778417
Glomerular filtration rate 16.40 10.73 9 173287 106 34783529
Peptic ulcer 16.38 10.73 40 173256 2743 34780892
Hepatic rupture 16.37 10.73 7 173289 45 34783590
Infected skin ulcer 16.36 10.73 29 173267 1584 34782051
Mouth ulceration 16.34 10.73 21 173275 11889 34771746
Spinal cord haematoma 16.33 10.73 9 173287 107 34783528
Puncture site haematoma 16.31 10.73 10 173286 147 34783488
Craniotomy 16.31 10.73 10 173286 147 34783488
Electrolyte imbalance 16.30 10.73 29 173267 14383 34769252
Infusion site pain 16.28 10.73 49 173247 3802 34779833
Device occlusion 16.27 10.73 70 173226 6475 34777160
Aortic stenosis 16.17 10.73 53 173243 4305 34779330
Implantable defibrillator replacement 16.12 10.73 5 173291 10 34783625
Cardiac ventricular thrombosis 16.04 10.73 24 173272 1136 34782499
Hypophagia 16.04 10.73 186 173110 23836 34759799
Incarcerated hernia 16.02 10.73 10 173286 152 34783483
Catheter site infection 16.01 10.73 38 173258 2559 34781076
Mental disorder 15.98 10.73 32 173264 15177 34768458
Cardiolipin antibody positive 15.96 10.73 6 173290 26 34783609
Right atrial enlargement 15.94 10.73 12 173284 251 34783384
Infusion site erythema 15.94 10.73 35 173261 2238 34781397
Urinary bladder haemorrhage 15.91 10.73 30 173266 1719 34781916
Epstein-Barr virus infection 15.90 10.73 9 173287 7619 34776016
Tongue haemorrhage 15.85 10.73 17 173279 573 34783062
Osteoarthritis 15.82 10.73 51 173245 20591 34763044
Vascular calcification 15.82 10.73 20 173276 806 34782829
Protein C decreased 15.78 10.73 6 173290 27 34783608
Medical device site haematoma 15.78 10.73 6 173290 27 34783608
Conjunctivitis 15.63 10.73 15 173281 9690 34773945
Mitral valve thickening 15.53 10.73 14 173282 380 34783255
Coagulation test abnormal 15.52 10.73 17 173279 587 34783048
Acute respiratory distress syndrome 15.50 10.73 71 173225 25898 34757737
Spinal cord haemorrhage 15.48 10.73 13 173283 320 34783315
Radiation proctitis 15.44 10.73 9 173287 120 34783515
Anaesthesia 15.41 10.73 7 173289 53 34783582
Bronchiectasis 15.33 10.73 92 173204 9709 34773926
Oesophageal ulcer 15.23 10.73 44 173252 3337 34780298
Sinus node dysfunction 15.16 10.73 51 173245 4198 34779437
Cerebellar haematoma 15.16 10.73 11 173285 217 34783418
Gastrointestinal ulcer 15.13 10.73 29 173267 1682 34781953
Polyneuropathy 15.09 10.73 32 173264 14864 34768771
Cardioactive drug level increased 15.06 10.73 29 173267 1688 34781947
Hepatic haematoma 15.05 10.73 14 173282 396 34783239
Muscle rigidity 15.00 10.73 18 173278 10500 34773135
Cytopenia 14.94 10.73 25 173271 12698 34770937
Hypogammaglobulinaemia 14.93 10.73 10 173286 7730 34775905
Periorbital haematoma 14.92 10.73 13 173283 337 34783298
Hepatitis C 14.92 10.73 16 173280 9814 34773821
Toxic epidermal necrolysis 14.90 10.73 56 173240 21590 34762045
Splenic rupture 14.73 10.73 27 173269 1514 34782121
Strangury 14.70 10.73 9 173287 132 34783503
Gastrointestinal erosion 14.68 10.73 14 173282 409 34783226
Heart valve operation 14.67 10.73 7 173289 60 34783575
Blood pressure diastolic abnormal 14.66 10.73 3 173293 4815 34778820
Injection site erythema 14.61 10.73 36 173260 15863 34767772
Incision site haematoma 14.60 10.73 8 173288 94 34783541
Hepatic encephalopathy 14.50 10.73 32 173264 14653 34768982
Syringe issue 14.45 10.73 5 173291 5659 34777976
Brain natriuretic peptide increased 14.44 10.73 61 173235 5598 34778037
Neutropenic sepsis 14.43 10.73 29 173267 13738 34769897
Blood urea increased 14.41 10.73 221 173075 30143 34753492
Pulmonary haematoma 14.38 10.73 7 173289 63 34783572
Euphoric mood 14.36 10.73 5 173291 5636 34777999
Eye haematoma 14.28 10.73 7 173289 64 34783571
N-telopeptide urine increased 14.24 10.73 6 173290 37 34783598
Blood uric acid increased 14.21 10.73 89 173207 9535 34774100
Jugular vein distension 14.16 10.73 17 173279 649 34782986
Procedural site reaction 14.10 10.73 10 173286 190 34783445
Feeling hot 14.07 10.73 49 173247 19323 34764312
Respiratory depression 14.00 10.73 38 173258 16207 34767428
Transaminases increased 13.91 10.73 77 173219 26746 34756889
Muscle spasms 13.89 10.73 275 173021 74726 34708909
Disease recurrence 13.89 10.73 57 173239 21433 34762202
Cerebral infarction 13.88 10.73 202 173094 27253 34756382
Antiphospholipid antibodies positive 13.87 10.73 12 173284 308 34783327
Oesophageal ulcer haemorrhage 13.84 10.73 10 173286 196 34783439
Tumour haemorrhage 13.78 10.73 39 173257 2923 34780712
Vascular pseudoaneurysm 13.67 10.73 32 173264 2135 34781500
Arteriovenous fistula site haemorrhage 13.64 10.73 8 173288 108 34783527
Gastrointestinal angiodysplasia 13.62 10.73 16 173280 597 34783038
Protein C deficiency 13.61 10.73 4 173292 6 34783629
Panic attack 13.60 10.73 16 173280 9416 34774219
Crying 13.60 10.73 6 173290 5856 34777779
Catatonia 13.60 10.73 4 173292 5021 34778614
Concomitant disease progression 13.57 10.73 35 173261 2483 34781152
Weight decreased 13.56 10.73 725 172571 175576 34608059
Lipase increased 13.55 10.73 16 173280 9400 34774235
Cardiac valve disease 13.49 10.73 40 173256 3078 34780557
Large intestine polyp 13.49 10.73 76 173220 7838 34775797
Ascites 13.46 10.73 314 172982 46257 34737378
Spinal osteoarthritis 13.43 10.73 11 173285 7672 34775963
Incision site haemorrhage 13.41 10.73 15 173281 530 34783105
Endarterectomy 13.40 10.73 9 173287 156 34783479
Diarrhoea 13.28 10.73 1712 171584 388200 34395435
Haemorrhagic infarction 13.26 10.73 14 173282 463 34783172
Ulnar nerve palsy 13.24 10.73 4 173292 7 34783628
Night sweats 13.21 10.73 43 173253 17309 34766326
Erectile dysfunction 13.18 10.73 55 173241 20582 34763053
Hyperthermia 13.16 10.73 20 173276 10557 34773078
Cardiac disorder 13.15 10.73 293 173003 42833 34740802
Maternal exposure during pregnancy 13.15 10.73 4 173292 4914 34778721
Eye haemorrhage 13.07 10.73 49 173247 4256 34779379
Proctalgia 13.05 10.73 6 173290 5717 34777918
Femoral artery aneurysm 13.02 10.73 9 173287 164 34783471
Acute cutaneous lupus erythematosus 13.02 10.73 7 173289 79 34783556
Increased tendency to bruise 12.98 10.73 47 173249 4014 34779621
Cognitive disorder 12.98 10.73 86 173210 28607 34755028
Frequent bowel movements 12.94 10.73 108 173188 12679 34770956
Eye infection intraocular 12.94 10.73 3 173293 0 34783635
Arteriovenous graft site haemorrhage 12.94 10.73 3 173293 0 34783635
Vascular fragility 12.94 10.73 3 173293 0 34783635
Cardiolipin antibody 12.94 10.73 3 173293 0 34783635
Delusion 12.92 10.73 27 173269 12608 34771027
Cor pulmonale 12.92 10.73 18 173278 798 34782837
Erythema 12.92 10.73 338 172958 88442 34695193
Uveitis 12.91 10.73 11 173285 7524 34776111
Aortic valve replacement 12.83 10.73 18 173278 803 34782832
Klebsiella infection 12.82 10.73 14 173282 8517 34775118
Basal cell carcinoma 12.80 10.73 52 173244 19606 34764029
Impaired quality of life 12.80 10.73 60 173236 5758 34777877
Pulmonary calcification 12.74 10.73 10 173286 223 34783412
Blood pressure systolic decreased 12.65 10.73 50 173246 4453 34779182
Pulmonary haemorrhage 12.63 10.73 91 173205 10213 34773422
Hypertransaminasaemia 12.60 10.73 6 173290 5600 34778035
Upper airway obstruction 12.57 10.73 16 173280 649 34782986
Product storage error 12.57 10.73 13 173283 8109 34775526
Agranulocytosis 12.57 10.73 68 173228 23753 34759882
Subdural haematoma evacuation 12.57 10.73 5 173291 26 34783609
Walking distance test abnormal 12.56 10.73 9 173287 174 34783461
Myocarditis 12.56 10.73 31 173265 13651 34769984
Skin lesion 12.54 10.73 61 173235 21900 34761735
Infusion site warmth 12.52 10.73 8 173288 127 34783508
Hypercholesterolaemia 12.49 10.73 15 173281 8747 34774888
Brain stem haemorrhage 12.49 10.73 19 173277 913 34782722
Ankle deformity 12.44 10.73 10 173286 231 34783404
Orthostatic hypotension 12.43 10.73 189 173107 25730 34757905
Paracentesis 12.39 10.73 13 173283 427 34783208
Prothrombin level decreased 12.38 10.73 21 173275 1107 34782528
Thrombotic microangiopathy 12.38 10.73 21 173275 10609 34773026
Oesophageal pain 12.37 10.73 18 173278 831 34782804
Burns second degree 12.37 10.73 21 173275 1108 34782527
Cellulitis 12.36 10.73 347 172949 52604 34731031
Emotional distress 12.32 10.73 36 173260 14990 34768645
Elbow operation 12.30 10.73 8 173288 131 34783504
Hydrocephalus 12.28 10.73 55 173241 5177 34778458
Libido decreased 12.24 10.73 4 173292 4692 34778943
Cardiac pacemaker replacement 12.21 10.73 9 173287 182 34783453
Encephalopathy 12.18 10.73 114 173182 35205 34748430
Thrombectomy 12.16 10.73 7 173289 91 34783544
Femoral nerve palsy 12.14 10.73 6 173290 56 34783579
Mean platelet volume increased 12.05 10.73 14 173282 516 34783119
Presyncope 12.03 10.73 146 173150 18913 34764722
Aortic bruit 12.02 10.73 10 173286 243 34783392
Tricuspid valve replacement 11.98 10.73 5 173291 30 34783605
Inappropriate schedule of product administration 11.97 10.73 227 173069 62069 34721566
Catheter site swelling 11.95 10.73 12 173284 374 34783261
Gout 11.94 10.73 147 173149 19106 34764529
Hypocalcaemia 11.91 10.73 71 173225 24218 34759417
Refusal of treatment by patient 11.89 10.73 53 173243 4979 34778656
Pulmonary arterial pressure increased 11.88 10.73 22 173274 1243 34782392
Heartland virus infection 11.84 10.73 5 173291 31 34783604
Coagulation factor V level increased 11.84 10.73 5 173291 31 34783604
Aplasia 11.79 10.73 4 173292 4584 34779051
Vitreous haemorrhage 11.79 10.73 32 173264 2341 34781294
Aphthous ulcer 11.76 10.73 5 173291 4990 34778645
Ubiquinone decreased 11.76 10.73 4 173292 12 34783623
Procalcitonin 11.76 10.73 4 173292 12 34783623
Lymphoma 11.75 10.73 28 173268 12479 34771156
Cardiac ventricular disorder 11.74 10.73 10 173286 251 34783384
Cardioactive drug level above therapeutic 11.70 10.73 6 173290 61 34783574
Haemorrhoids 11.65 10.73 117 173179 14458 34769177
Blood potassium increased 11.59 10.73 129 173167 16366 34767269
Cardiac pseudoaneurysm 11.58 10.73 5 173291 33 34783602
Metastatic carcinoid tumour 11.52 10.73 4 173292 13 34783622
Disorientation 11.50 10.73 107 173189 33081 34750554
Infusion site haemorrhage 11.43 10.73 19 173277 985 34782650
Cystitis haemorrhagic 11.41 10.73 7 173289 5672 34777963
Burning feet syndrome 11.41 10.73 7 173289 103 34783532
Pseudomonas infection 11.41 10.73 28 173268 12354 34771281
Muscle twitching 11.40 10.73 21 173275 10277 34773358
Hemiparesis 11.36 10.73 124 173172 15654 34767981
Bradyarrhythmia 11.34 10.73 30 173266 2161 34781474
Antiphospholipid antibodies 11.30 10.73 4 173292 14 34783621
Left ventricular failure 11.28 10.73 53 173243 5091 34778544
Post procedural haematoma 11.27 10.73 24 173272 1502 34782133
Bladder cancer 11.27 10.73 42 173254 16236 34767399
Hyperammonaemia 11.27 10.73 9 173287 6358 34777277
Wound haemorrhage 11.26 10.73 29 173267 2056 34781579
Atrial septal defect 11.25 10.73 12 173284 7380 34776255
Atrial septal defect repair 11.24 10.73 7 173289 106 34783529
Therapeutic procedure 11.23 10.73 9 173287 207 34783428
Throat tightness 11.20 10.73 15 173281 8343 34775292
Therapeutic response increased 11.14 10.73 10 173286 270 34783365
Procedural haemorrhage 11.09 10.73 32 173264 2425 34781210
Salivary hypersecretion 11.09 10.73 16 173280 8628 34775007
Mood altered 11.07 10.73 17 173279 8935 34774700
Normocytic anaemia 11.04 10.73 31 173265 2313 34781322
Protein-losing gastroenteropathy 10.95 10.73 11 173285 343 34783292
Heart transplant 10.94 10.73 18 173278 925 34782710
Wound decomposition 10.91 10.73 6 173290 71 34783564
Tuberculosis 10.88 10.73 16 173280 8561 34775074
Epiphyseal disorder 10.87 10.73 3 173293 3 34783632
Breast haematoma 10.87 10.73 3 173293 3 34783632
Alkalosis hypokalaemic 10.87 10.73 3 173293 3 34783632
Atelectasis 10.86 10.73 48 173248 17679 34765956
Nephrolithiasis 10.86 10.73 97 173199 30236 34753399
Aneurysm ruptured 10.79 10.73 13 173283 498 34783137

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 18570.57 9.93 8295 314616 76426 79345051
Haemorrhage 2389.02 9.93 2357 320554 88761 79332716
International normalised ratio abnormal 2211.65 9.93 845 322066 4923 79416554
Gastric haemorrhage 2075.82 9.93 1076 321835 13974 79407503
Drug interaction 2015.32 9.93 4878 318033 410305 79011172
International normalised ratio decreased 1795.12 9.93 801 322110 7269 79414208
Gastrointestinal haemorrhage 1653.46 9.93 2482 320429 145237 79276240
Anticoagulation drug level above therapeutic 1608.98 9.93 591 322320 3029 79418448
Calciphylaxis 1239.22 9.93 494 322417 3276 79418201
Subdural haematoma 1220.86 9.93 1015 321896 30419 79391058
Haematoma 1218.71 9.93 1269 321642 50926 79370551
Melaena 999.69 9.93 1233 321678 59657 79361820
Haematuria 985.24 9.93 1302 321609 67534 79353943
Epistaxis 938.00 9.93 1647 321264 109868 79311609
Drug ineffective 895.98 9.93 1906 321005 1079007 78342470
Haemorrhage intracranial 859.19 9.93 768 322143 25425 79396052
Pulmonary arterial hypertension 848.92 9.93 790 322121 27576 79393901
Labelled drug-drug interaction medication error 710.26 9.93 708 322203 26942 79394535
Anticoagulation drug level below therapeutic 698.75 9.93 255 322656 1278 79420199
Cerebral haemorrhage 685.95 9.93 998 321913 56675 79364802
Haemoglobin decreased 680.67 9.93 2212 320699 219907 79201570
Cardiac failure congestive 670.51 9.93 1657 321254 140745 79280732
Fluid retention 655.33 9.93 1083 321828 68726 79352751
Anaemia 632.70 9.93 3504 319407 441511 78979966
Off label use 594.28 9.93 1801 321110 905414 78516063
Prothrombin time prolonged 589.16 9.93 513 322398 16386 79405091
International normalised ratio fluctuation 579.18 9.93 282 322629 3172 79418305
Rectal haemorrhage 578.99 9.93 1078 321833 75222 79346255
Dyspnoea 567.34 9.93 5621 317290 851404 78570073
Synovitis 555.75 9.93 11 322900 150723 79270754
Coagulopathy 485.84 9.93 662 322249 35344 79386133
Haemoptysis 479.49 9.93 834 322077 55165 79366312
Cardiac failure 471.22 9.93 1539 321372 153303 79268174
Pulmonary hypertension 459.37 9.93 752 322159 47328 79374149
Infusion related reaction 458.79 9.93 179 322732 230058 79191419
Drug intolerance 439.99 9.93 262 322649 263857 79157620
Atrial fibrillation 437.07 9.93 1772 321139 196114 79225363
Febrile neutropenia 427.70 9.93 200 322711 230799 79190678
Abdominal wall haematoma 425.06 9.93 258 322653 4615 79416862
Right ventricular failure 410.13 9.93 491 322420 23006 79398471
Muscle haemorrhage 402.09 9.93 274 322637 6026 79415451
Pemphigus 385.79 9.93 3 322908 99579 79321898
Pain in jaw 385.56 9.93 680 322231 45471 79376006
Rheumatoid arthritis 361.15 9.93 197 322714 208273 79213204
Hypervolaemia 350.17 9.93 624 322287 42066 79379411
Joint swelling 347.32 9.93 394 322517 288252 79133225
Therapeutic product effect decreased 340.50 9.93 119 322792 163744 79257733
Catheter site erythema 334.67 9.93 228 322683 5012 79416465
Arthralgia 333.95 9.93 1192 321719 570611 78850866
Alopecia 325.44 9.93 275 322636 231080 79190397
Upper gastrointestinal haemorrhage 311.74 9.93 583 322328 40797 79380680
Ecchymosis 309.52 9.93 344 322567 14862 79406615
Hand deformity 309.18 9.93 31 322880 103888 79317589
Transfusion 302.72 9.93 402 322509 20928 79400549
Retroperitoneal haematoma 299.77 9.93 214 322697 5083 79416394
Drug hypersensitivity 296.65 9.93 470 322441 298446 79123031
Fall 294.18 9.93 3142 319769 484487 78936990
Treatment failure 283.94 9.93 169 322742 170317 79251160
Dyspnoea exertional 281.56 9.93 884 322027 86189 79335288
Drug abuse 274.16 9.93 159 322752 162532 79258945
Arthropathy 269.96 9.93 194 322717 176917 79244560
Faeces discoloured 269.34 9.93 449 322462 28678 79392799
Hypersensitivity 269.11 9.93 403 322508 261836 79159641
Glossodynia 266.72 9.93 48 322863 103289 79318188
Subarachnoid haemorrhage 258.87 9.93 401 322510 24064 79397413
Musculoskeletal stiffness 257.32 9.93 199 322712 174809 79246668
Pain 255.31 9.93 1736 321175 702066 78719411
Thrombosis 253.92 9.93 834 322077 83266 79338211
Subdural haemorrhage 253.85 9.93 203 322708 5745 79415732
Neutropenia 247.90 9.93 494 322417 287216 79134261
Stomatitis 246.46 9.93 144 322767 146613 79274864
Contraindicated product administered 244.78 9.93 169 322742 157369 79264108
Pericarditis 243.29 9.93 61 322850 104175 79317302
Catheter site pain 242.83 9.93 190 322721 5206 79416271
Hepatic enzyme increased 233.17 9.93 237 322674 182373 79239104
Device related infection 232.37 9.93 462 322449 33832 79387645
Product use in unapproved indication 232.28 9.93 411 322500 249948 79171529
Catheter management 230.66 9.93 158 322753 3505 79417972
Oedema peripheral 228.05 9.93 1775 321136 250513 79170964
Retroperitoneal haemorrhage 217.22 9.93 179 322732 5291 79416186
Coagulation time prolonged 214.80 9.93 131 322780 2364 79419113
Duodenal ulcer perforation 212.88 9.93 14 322897 66197 79355280
Syncope 212.23 9.93 1348 321563 178101 79243376
Haematemesis 211.56 9.93 575 322336 51689 79369788
Rash 209.81 9.93 1426 321485 576932 78844545
Haematocrit decreased 207.96 9.93 633 322278 60679 79360798
Product use issue 207.02 9.93 331 322580 209491 79211986
Therapeutic product effect incomplete 204.50 9.93 164 322747 141481 79279996
Catheter site discharge 203.45 9.93 125 322786 2287 79419190
Hypotension 196.00 9.93 2679 320232 437638 78983839
Pyrexia 190.95 9.93 1793 321118 676916 78744561
Heparin-induced thrombocytopenia 190.15 9.93 215 322696 9467 79412010
Folliculitis 189.66 9.93 8 322903 55372 79366105
Helicobacter infection 189.66 9.93 28 322883 69676 79351801
Discomfort 186.97 9.93 141 322770 125476 79296001
Lower gastrointestinal haemorrhage 182.90 9.93 273 322638 15852 79405625
Intraventricular haemorrhage 179.75 9.93 153 322758 4734 79416743
Haemarthrosis 177.95 9.93 164 322747 5648 79415829
Psoriatic arthropathy 177.52 9.93 48 322863 77951 79343526
Catheter site pruritus 176.28 9.93 112 322799 2179 79419298
Intra-abdominal haematoma 171.01 9.93 120 322791 2771 79418706
Central venous catheterisation 170.48 9.93 126 322785 3163 79418314
Catheter site haemorrhage 169.66 9.93 151 322760 4966 79416511
Systemic lupus erythematosus 169.03 9.93 145 322766 121004 79300473
Shock haemorrhagic 162.91 9.93 292 322619 19768 79401709
Catheter site infection 161.69 9.93 167 322744 6628 79414849
Device alarm issue 157.94 9.93 101 322810 1988 79419489
Wound 156.14 9.93 144 322767 116035 79305442
Oedema 155.65 9.93 921 321990 118659 79302818
Blood loss anaemia 155.60 9.93 248 322663 15250 79406227
Sinusitis 155.47 9.93 351 322560 195150 79226327
Deep vein thrombosis 155.27 9.93 928 321983 119991 79301486
Haematoma muscle 153.41 9.93 108 322803 2507 79418970
Completed suicide 152.79 9.93 498 322413 245269 79176208
Skin necrosis 151.66 9.93 267 322644 17820 79403657
COVID-19 150.58 9.93 254 322657 157420 79264057
Sleep disorder due to general medical condition, insomnia type 150.13 9.93 6 322905 43550 79377927
Mucosal inflammation 150.02 9.93 59 322852 75521 79345956
Irritable bowel syndrome 150.00 9.93 34 322877 62207 79359270
Maternal exposure during pregnancy 149.71 9.93 200 322711 136338 79285139
Cerebrovascular accident 148.82 9.93 1108 321803 154184 79267293
Head injury 147.12 9.93 407 322504 36962 79384515
Intentional overdose 145.17 9.93 129 322782 105831 79315646
Thrombosis in device 140.91 9.93 140 322771 5302 79416175
Depression 139.85 9.93 432 322479 216358 79205119
Exposure during pregnancy 138.70 9.93 123 322788 101009 79320468
Pruritus 134.58 9.93 990 321921 393658 79027819
Malignant neoplasm progression 134.58 9.93 214 322697 135776 79285701
Leukopenia 132.55 9.93 166 322745 116347 79305130
Catheter placement 132.27 9.93 104 322807 2870 79418607
Hypertension 131.05 9.93 794 322117 330198 79091279
Muscle injury 128.71 9.93 21 322890 48540 79372937
Activated partial thromboplastin time prolonged 128.42 9.93 217 322694 14011 79407466
Spinal epidural haematoma 127.94 9.93 77 322834 1355 79420122
Urticaria 126.71 9.93 359 322552 184842 79236635
Occult blood positive 125.33 9.93 147 322764 6736 79414741
Injection site pain 123.19 9.93 210 322701 129628 79291849
Anaphylactic reaction 119.54 9.93 98 322813 83645 79337832
Asthma 118.79 9.93 229 322682 134866 79286611
Haemorrhagic stroke 118.18 9.93 182 322729 10864 79410613
Post procedural haemorrhage 116.68 9.93 204 322707 13540 79407937
Catheter site swelling 116.57 9.93 80 322831 1780 79419697
Infection 115.55 9.93 544 322367 241168 79180309
Infusion site pain 114.66 9.93 206 322705 13970 79407507
Cytokine release syndrome 114.58 9.93 8 322903 35990 79385487
Intentional product use issue 113.03 9.93 283 322628 151829 79269648
Atrial flutter 112.75 9.93 262 322649 21363 79400114
General physical health deterioration 112.22 9.93 654 322257 274584 79146893
Anticoagulant-related nephropathy 111.89 9.93 31 322880 46 79421431
Paraesthesia 109.74 9.93 357 322554 175966 79245511
Intestinal haematoma 108.59 9.93 39 322872 185 79421292
Blister 108.14 9.93 199 322712 119277 79302200
Haemoperitoneum 107.44 9.93 109 322802 4234 79417243
Haemorrhage subcutaneous 106.94 9.93 114 322797 4695 79416782
Fibromyalgia 106.75 9.93 64 322847 64276 79357201
Dizziness 106.36 9.93 2837 320074 523604 78897873
Injection site reaction 105.10 9.93 45 322866 54740 79366737
Gingival bleeding 103.98 9.93 214 322697 16062 79405415
Osteoarthritis 103.97 9.93 120 322791 87189 79334288
Myelosuppression 103.35 9.93 19 322892 40277 79381200
Appendicolith 101.63 9.93 148 322763 8403 79413074
Complication associated with device 101.30 9.93 221 322690 17275 79404202
Cerebral mass effect 101.00 9.93 74 322837 1832 79419645
Impaired healing 100.62 9.93 124 322787 87531 79333946
Cardiac pacemaker insertion 100.50 9.93 121 322790 5701 79415776
Inflammation 100.07 9.93 140 322771 93613 79327864
Ventricular tachycardia 99.21 9.93 384 322527 41551 79379926
Psoriasis 98.42 9.93 131 322780 89456 79332021
Spontaneous haematoma 98.31 9.93 65 322846 1357 79420120
Blood cholesterol increased 96.56 9.93 118 322793 83602 79337875
Injection site erythema 95.81 9.93 105 322806 78092 79343385
Extradural haematoma 95.61 9.93 85 322826 2791 79418686
Lower respiratory tract infection 93.99 9.93 243 322668 128977 79292500
Cardiogenic shock 92.87 9.93 376 322535 41538 79379939
Subcutaneous haematoma 92.17 9.93 82 322829 2695 79418782
Suicidal ideation 90.81 9.93 105 322806 76235 79345242
Lung transplant 90.79 9.93 102 322809 4459 79417018
Type 2 diabetes mellitus 90.39 9.93 60 322851 57062 79364415
Palpitations 90.08 9.93 845 322066 125765 79295712
C-reactive protein increased 89.79 9.93 248 322663 128779 79292698
Sleep disorder 89.40 9.93 130 322781 85547 79335930
Device leakage 89.40 9.93 159 322752 10697 79410780
Drug dependence 89.23 9.93 27 322884 40742 79380735
Traumatic haematoma 88.90 9.93 71 322840 2005 79419472
Cerebellar haemorrhage 88.63 9.93 82 322829 2838 79418639
Prothrombin time ratio increased 87.92 9.93 36 322875 258 79421219
Hospitalisation 87.76 9.93 668 322243 93568 79327909
Pancytopenia 87.69 9.93 359 322552 165386 79256091
Infusion site infection 87.34 9.93 66 322845 1715 79419762
Ill-defined disorder 86.90 9.93 83 322828 65792 79355685
Death 86.11 9.93 2948 319963 563566 78857911
Pulmonary alveolar haemorrhage 84.50 9.93 160 322751 11297 79410180
Presyncope 84.46 9.93 360 322551 40694 79380783
Bradycardia 84.43 9.93 880 322031 134677 79286800
Neutrophil count decreased 83.70 9.93 158 322753 93801 79327676
Suicide attempt 83.46 9.93 129 322782 82803 79338674
Toxicity to various agents 83.43 9.93 1203 321708 420337 79001140
Pulmonary embolism 82.60 9.93 1060 321851 170594 79250883
Hypoaesthesia 81.42 9.93 411 322500 178941 79242536
Blood pressure decreased 80.60 9.93 683 322228 98783 79322694
Anxiety 80.08 9.93 633 322278 247879 79173598
Asthenia 78.30 9.93 2665 320246 509024 78912453
Ear haemorrhage 78.25 9.93 67 322844 2090 79419387
Intra-abdominal haemorrhage 77.78 9.93 94 322817 4446 79417031
Coagulation test abnormal 77.63 9.93 55 322856 1290 79420187
Device occlusion 76.96 9.93 157 322754 11709 79409768
Contusion 76.41 9.93 930 321981 147846 79273631
Multiple sclerosis relapse 76.20 9.93 47 322864 46486 79374991
Catheter site inflammation 76.09 9.93 51 322860 1090 79420387
Hypercoagulation 75.51 9.93 76 322835 2924 79418553
Cardiac tamponade 75.28 9.93 135 322776 9141 79412336
Injection site pruritus 74.55 9.93 39 322872 42244 79379233
Cardiac failure chronic 74.21 9.93 149 322762 10986 79410491
Pericardial haemorrhage 73.66 9.93 91 322820 4404 79417073
Internal haemorrhage 73.55 9.93 130 322781 8703 79412774
Hypocoagulable state 72.15 9.93 64 322847 2095 79419382
Dialysis 71.59 9.93 200 322711 18262 79403215
Gastrointestinal disorder 71.54 9.93 254 322657 121951 79299526
Chest pain 70.63 9.93 1567 321344 280737 79140740
Cardiac failure acute 70.42 9.93 202 322709 18727 79402750
Swollen joint count increased 70.42 9.93 6 322905 22921 79398556
Flushing 70.41 9.93 604 322307 87664 79333813
Cardiac operation 70.40 9.93 94 322817 4918 79416559
Haematochezia 70.05 9.93 600 322311 87045 79334432
Catheter site rash 69.63 9.93 46 322865 959 79420518
Red blood cell sedimentation rate increased 69.06 9.93 51 322860 45891 79375586
Conjunctival haemorrhage 68.96 9.93 101 322810 5764 79415713
Cardioactive drug level increased 68.84 9.93 80 322831 3629 79417848
Potentiating drug interaction 68.59 9.93 126 322785 8693 79412784
Choroidal haemorrhage 68.38 9.93 26 322885 149 79421328
Food interaction 68.22 9.93 56 322855 1646 79419831
Hyperkalaemia 68.12 9.93 736 322175 113662 79307815
Prothrombin time abnormal 67.97 9.93 47 322864 1059 79420418
Abdominal discomfort 67.82 9.93 668 322243 250059 79171418
Pulmonary arterial pressure increased 66.40 9.93 87 322824 4468 79417009
Compartment syndrome 66.36 9.93 92 322819 4990 79416487
Oxygen consumption increased 66.31 9.93 91 322820 4888 79416589
Blood pressure fluctuation 66.09 9.93 106 322805 67039 79354438
Wheezing 65.97 9.93 246 322665 116418 79305059
Pulmonary endarterectomy 65.53 9.93 27 322884 197 79421280
Gout 65.52 9.93 235 322676 24514 79396963
Haematoma evacuation 65.20 9.93 30 322881 294 79421183
Cardiac disorder 65.11 9.93 473 322438 65284 79356193
Acute myeloid leukaemia 64.85 9.93 22 322889 30863 79390614
Infusion site erythema 64.74 9.93 128 322783 9332 79412145
Oxygen saturation decreased 64.67 9.93 803 322108 128244 79293233
Colitis 63.78 9.93 125 322786 73182 79348295
Acute kidney injury 63.76 9.93 2640 320271 516764 78904713
Ventricular fibrillation 63.40 9.93 277 322634 31649 79389828
Bursitis 63.28 9.93 33 322878 35811 79385666
Loss of personal independence in daily activities 62.89 9.93 209 322702 102371 79319106
White blood cell count decreased 62.79 9.93 475 322436 187813 79233664
Injection site swelling 62.62 9.93 59 322852 47073 79374404
Adrenal haemorrhage 62.38 9.93 36 322875 584 79420893
International normalised ratio 62.37 9.93 22 322889 98 79421379
Generalised tonic-clonic seizure 61.90 9.93 52 322859 43858 79377619
Gastrointestinal arteriovenous malformation 61.53 9.93 42 322869 926 79420551
Cardiac valve replacement complication 61.38 9.93 26 322885 205 79421272
Catheterisation cardiac 60.74 9.93 94 322817 5634 79415843
Device expulsion 60.58 9.93 15 322896 25846 79395631
Gastritis erosive 60.52 9.93 135 322776 10712 79410765
Medical device change 60.40 9.93 33 322878 479 79420998
Foot deformity 60.36 9.93 12 322899 24062 79397415
Seizure 60.34 9.93 482 322429 188352 79233125
Serotonin syndrome 60.25 9.93 56 322855 44971 79376506
Accidental exposure to product 59.65 9.93 26 322885 31296 79390181
Dystonia 59.60 9.93 8 322903 21391 79400086
Vascular pseudoaneurysm 59.04 9.93 72 322839 3438 79418039
Cerebral haematoma 58.68 9.93 111 322800 7831 79413646
Pulmonary oedema 58.32 9.93 580 322331 87674 79333803
Insomnia 58.30 9.93 673 322238 244497 79176980
Brain natriuretic peptide increased 58.01 9.93 118 322793 8782 79412695
Illness 57.47 9.93 62 322849 46449 79375028
Device related sepsis 57.42 9.93 96 322815 6144 79415333
Neoplasm progression 57.34 9.93 75 322836 51607 79369870
Liver injury 57.02 9.93 88 322823 56526 79364951
Sedation 56.87 9.93 76 322835 51819 79369658
Haemothorax 56.84 9.93 89 322822 5389 79416088
Mobility decreased 56.57 9.93 278 322633 121897 79299580
Pelvic haematoma 56.54 9.93 38 322873 816 79420661
Cardioversion 56.23 9.93 55 322856 2043 79419434
Mediastinal haematoma 56.04 9.93 24 322887 195 79421282
Abdominal distension 55.49 9.93 734 322177 118916 79302561
Rheumatoid nodule 55.14 9.93 4 322907 17434 79404043
Atrial thrombosis 55.12 9.93 71 322840 3585 79417892
Blood pressure increased 55.12 9.93 568 322343 210792 79210685
Psychotic disorder 54.80 9.93 52 322859 41350 79380127
Arthritis 54.58 9.93 259 322652 114621 79306856
Hepatotoxicity 54.47 9.93 77 322834 51275 79370202
Prescribed overdose 54.47 9.93 44 322867 37839 79383638
Transplant evaluation 54.13 9.93 49 322862 1648 79419829
Cytomegalovirus infection 53.64 9.93 56 322855 42588 79378889
Brain herniation 53.53 9.93 103 322808 7360 79414117
Gastric ulcer haemorrhage 53.37 9.93 115 322796 8912 79412565
Scrotal haematoma 53.16 9.93 18 322893 69 79421408
Hepatic cytolysis 52.56 9.93 22 322889 27129 79394348
Mesenteric haematoma 51.69 9.93 14 322897 18 79421459
Congestive hepatopathy 51.59 9.93 77 322834 4470 79417007
Transient ischaemic attack 51.57 9.93 378 322533 52317 79369160
Antiphospholipid syndrome 51.48 9.93 50 322861 1841 79419636
Thrombocytopenia 51.01 9.93 761 322150 264498 79156979
Pulmonary haemorrhage 50.87 9.93 153 322758 14564 79406913
Spinal subdural haematoma 50.84 9.93 23 322888 216 79421261
Ascites 50.61 9.93 498 322413 75064 79346413
Cellulitis 50.14 9.93 668 322243 108392 79313085
Duodenal ulcer 49.97 9.93 163 322748 16206 79405271
Hyphaema 49.95 9.93 36 322875 868 79420609
Protein C decreased 49.84 9.93 17 322894 67 79421410
Venous pressure jugular increased 49.38 9.93 42 322869 1298 79420179
Anticoagulation drug level decreased 49.32 9.93 21 322890 168 79421309
Obesity 49.02 9.93 42 322869 35083 79386394
Oral herpes 48.88 9.93 25 322886 27429 79394048
Night sweats 48.71 9.93 85 322826 52010 79369467
Angioedema 48.64 9.93 152 322759 75883 79345594
Eye haemorrhage 48.46 9.93 116 322795 9641 79411836
Therapeutic response decreased 48.38 9.93 126 322785 66727 79354750
Pulmonary thrombosis 48.33 9.93 133 322778 12038 79409439
Tongue haematoma 48.32 9.93 22 322889 210 79421267
Mouth haemorrhage 48.24 9.93 124 322787 10775 79410702
Therapy change 48.11 9.93 98 322813 7301 79414176
Intentional self-injury 47.43 9.93 37 322874 32382 79389095
Diverticulum intestinal haemorrhagic 47.06 9.93 69 322842 3942 79417535
Spinal cord haematoma 47.00 9.93 24 322887 301 79421176
Arteriovenous malformation 46.89 9.93 46 322865 1715 79419762
Nasal congestion 46.72 9.93 495 322416 76057 79345420
Wrong technique in product usage process 46.33 9.93 149 322762 73726 79347751
Intracardiac thrombus 46.30 9.93 71 322840 4222 79417255
Gangrene 46.07 9.93 108 322803 8856 79412621
Lymphopenia 45.83 9.93 34 322877 30523 79390954
Agitation 45.52 9.93 228 322683 99487 79321990
Lymphocyte count decreased 45.28 9.93 76 322835 47213 79374264
Catheter removal 45.18 9.93 30 322881 631 79420846
Coagulation time shortened 44.35 9.93 25 322886 387 79421090
Drug ineffective for unapproved indication 44.02 9.93 88 322823 51150 79370327
Muscle spasticity 43.88 9.93 16 322895 21459 79400018
Hip arthroplasty 43.81 9.93 48 322863 35708 79385769
Sedation complication 43.30 9.93 6 322905 15663 79405814
Bronchopulmonary aspergillosis 43.26 9.93 18 322893 22276 79399201
Aphthous ulcer 43.23 9.93 8 322903 16881 79404596
Embolic stroke 43.21 9.93 97 322814 7729 79413748
Immunodeficiency 43.18 9.93 17 322894 21751 79399726
Medical device site thrombosis 42.66 9.93 13 322898 32 79421445
Heart valve replacement 42.58 9.93 33 322878 891 79420586
Vitamin K deficiency 42.55 9.93 30 322881 698 79420779
Renal haemorrhage 42.44 9.93 49 322862 2207 79419270
Mallory-Weiss syndrome 42.39 9.93 55 322856 2797 79418680
Chest wall haematoma 42.35 9.93 25 322886 424 79421053
Prosthetic cardiac valve thrombosis 42.33 9.93 14 322897 49 79421428
Traumatic intracranial haemorrhage 42.00 9.93 37 322874 1200 79420277
Appendicitis 41.73 9.93 181 322730 20613 79400864
Basal cell carcinoma 41.71 9.93 54 322857 37321 79384156
Hepatocellular injury 41.53 9.93 81 322830 47512 79373965
Hypercholesterolaemia 41.16 9.93 21 322890 23074 79398403
Febrile bone marrow aplasia 41.13 9.93 3 322908 13017 79408460
Rash maculo-papular 41.11 9.93 105 322806 55973 79365504
Knee arthroplasty 40.95 9.93 70 322841 43178 79378299
Duodenal ulcer haemorrhage 40.92 9.93 90 322821 7073 79414404
Aggression 40.87 9.93 91 322820 50867 79370610
Blue toe syndrome 40.82 9.93 27 322884 564 79420913
Aplastic anaemia 40.77 9.93 11 322900 17894 79403583
Foetal warfarin syndrome 40.62 9.93 9 322902 0 79421477
Dry eye 40.55 9.93 54 322857 36877 79384600
Pneumocystis jirovecii pneumonia 40.54 9.93 43 322868 32465 79389012
Swelling 40.53 9.93 625 322286 216086 79205391
Disturbance in attention 40.51 9.93 91 322820 50710 79370767
Diabetic ketoacidosis 40.50 9.93 47 322864 34075 79387402
Intentional product misuse 40.42 9.93 223 322688 94942 79326535
Penile necrosis 40.33 9.93 13 322898 41 79421436
Herpes zoster 40.15 9.93 217 322694 92866 79328611
Haemorrhagic diathesis 40.05 9.93 81 322830 6003 79415474
Therapeutic product effect increased 39.91 9.93 40 322871 1531 79419946
Dizziness postural 39.86 9.93 120 322791 11429 79410048
Hypoprothrombinaemia 39.75 9.93 29 322882 713 79420764
Neuropathy peripheral 39.22 9.93 374 322537 140931 79280546
Device connection issue 38.93 9.93 33 322878 1015 79420462
Hepatitis 38.84 9.93 107 322804 55620 79365857
Anticoagulation drug level increased 38.76 9.93 29 322882 742 79420735
Haemophagocytic lymphohistiocytosis 38.70 9.93 20 322891 21817 79399660
Cognitive disorder 38.52 9.93 149 322762 69777 79351700
Concomitant disease progression 38.25 9.93 58 322853 3415 79418062
Diverticulum 38.21 9.93 140 322771 14756 79406721
Blood phosphorus increased 38.08 9.93 110 322801 10237 79411240
Conjunctivitis 38.07 9.93 29 322882 25686 79395791
Product administration error 38.06 9.93 240 322671 31606 79389871
Lip dry 38 9.93 8 322903 15410 79406067
Vascular pseudoaneurysm ruptured 37.92 9.93 17 322894 156 79421321
Drug monitoring procedure not performed 37.90 9.93 32 322879 979 79420498
Joint stiffness 37.83 9.93 67 322844 40763 79380714
Cerebral infarction 37.71 9.93 315 322596 45361 79376116
Hypophagia 37.52 9.93 313 322598 45054 79376423
Thalamus haemorrhage 37.45 9.93 41 322870 1741 79419736
Anticoagulation drug level abnormal 37.33 9.93 11 322900 23 79421454
Injury 37.23 9.93 174 322737 77322 79344155
Osteoporosis 36.89 9.93 105 322806 54007 79367470
Bone marrow failure 36.47 9.93 97 322814 51010 79370467
Aortic valve replacement 36.23 9.93 35 322876 1280 79420197
Tracheal calcification 36.11 9.93 8 322903 0 79421477
Hydrocephalus 36.08 9.93 98 322813 8802 79412675
Neuroleptic malignant syndrome 36.02 9.93 35 322876 27524 79393953
Catheter site discolouration 36.00 9.93 15 322896 113 79421364
Catheter site irritation 35.97 9.93 25 322886 568 79420909
Gastric ulcer 35.96 9.93 248 322663 33657 79387820
Cardiac ablation 35.94 9.93 45 322866 2208 79419269
Exercise tolerance decreased 35.90 9.93 99 322812 8972 79412505
Palmar-plantar erythrodysaesthesia syndrome 35.82 9.93 49 322862 33085 79388392
Lymphadenopathy 35.81 9.93 104 322807 53143 79368334
Condition aggravated 35.64 9.93 1662 321249 499462 78922015
Sinus tachycardia 35.63 9.93 59 322852 36849 79384628
Mental status changes 35.41 9.93 421 322490 66538 79354939
Pregnancy 35.21 9.93 34 322877 26817 79394660
Orthopnoea 35.08 9.93 105 322806 9968 79411509
Drug resistance 35.00 9.93 74 322837 42139 79379338
Steroid dependence 34.92 9.93 48 322863 2582 79418895
Rales 34.85 9.93 167 322744 19834 79401643
Subarachnoid haematoma 34.76 9.93 19 322892 276 79421201
Pancreatitis acute 34.75 9.93 95 322816 49509 79371968
Dermatitis contact 34.70 9.93 111 322800 10922 79410555
Facet joint syndrome 34.59 9.93 3 322908 11299 79410178
Catheter site related reaction 34.57 9.93 33 322878 1189 79420288
Atrial tachycardia 34.56 9.93 84 322827 7049 79414428
Bradyarrhythmia 34.49 9.93 61 322850 4085 79417392
Schizophrenia 34.20 9.93 10 322901 15430 79406047
Prothrombin consumption time prolonged 34.05 9.93 11 322900 35 79421442
Sleep disorder due to a general medical condition 33.99 9.93 8 322903 14269 79407208
Emergency care 33.99 9.93 31 322880 1053 79420424
Lethargy 33.75 9.93 489 322422 80803 79340674
Obstructive airways disorder 33.54 9.93 47 322864 31412 79390065
Acute generalised exanthematous pustulosis 33.37 9.93 14 322897 17240 79404237
Joint range of motion decreased 33.26 9.93 52 322859 33230 79388247
Grip strength decreased 33.23 9.93 24 322887 21845 79399632
Infective pulmonary exacerbation of cystic fibrosis 33.08 9.93 6 322905 12845 79408632
Fatigue 33.01 9.93 3280 319631 926447 78495030
Ankylosing spondylitis 32.97 9.93 5 322906 12200 79409277
Aortic stenosis 32.89 9.93 85 322826 7410 79414067
Blood urea increased 32.88 9.93 322 322589 48468 79373009
Device interaction 32.87 9.93 26 322885 724 79420753
Endarterectomy 32.69 9.93 20 322891 363 79421114
Drug-induced liver injury 32.62 9.93 147 322764 65970 79355507
Restlessness 32.60 9.93 89 322822 46403 79375074
Large intestinal haemorrhage 32.54 9.93 48 322863 2757 79418720
Mineral supplementation 32.34 9.93 27 322884 813 79420664
Muscle spasms 32.30 9.93 505 322406 174225 79247252
Exostosis 32.09 9.93 14 322897 16844 79404633
Mouth ulceration 32.08 9.93 67 322844 38327 79383150
Arrhythmia 31.86 9.93 384 322527 60888 79360589
Anovulatory cycle 31.85 9.93 14 322897 122 79421355
Prescribed underdose 31.56 9.93 44 322867 29470 79392007
Sinus node dysfunction 31.42 9.93 85 322826 7616 79413861
Posterior reversible encephalopathy syndrome 31.41 9.93 36 322875 26245 79395232
Neurotoxicity 31.37 9.93 52 322859 32466 79389011
Autoimmune disorder 31.30 9.93 14 322897 16598 79404879
Inappropriate schedule of product administration 31.28 9.93 368 322543 133260 79288217
Mitral valve replacement 31.26 9.93 20 322891 394 79421083
Myxoedema coma 31.12 9.93 25 322886 712 79420765
Hyperhidrosis 31.07 9.93 429 322482 151063 79270414
Graft versus host disease 31.03 9.93 11 322900 15015 79406462
Laryngeal haematoma 31.02 9.93 15 322896 166 79421311
Acute respiratory failure 30.89 9.93 373 322538 59168 79362309
Infected skin ulcer 30.86 9.93 52 322859 3349 79418128
Poisoning deliberate 30.85 9.93 19 322892 18809 79402668
Therapy partial responder 30.74 9.93 16 322895 17381 79404096
Cholestasis 30.69 9.93 108 322803 52001 79369476
Immune reconstitution inflammatory syndrome 30.59 9.93 9 322902 13832 79407645
Blood creatinine increased 30.42 9.93 833 322078 154224 79267253
Ear pain 30.39 9.93 54 322857 32815 79388662
Sciatica 30.34 9.93 55 322856 33167 79388310
Tendonitis 30.30 9.93 31 322880 23799 79397678
Device infusion issue 30.21 9.93 42 322869 2284 79419193
Breast haematoma 30.03 9.93 15 322896 179 79421298
Infusion site haemorrhage 30.01 9.93 54 322857 3666 79417811
Deep vein thrombosis postoperative 29.99 9.93 4 322907 10748 79410729
Torsade de pointes 29.94 9.93 156 322755 19156 79402321
Catheter culture positive 29.85 9.93 16 322895 223 79421254
Haemorrhoidal haemorrhage 29.76 9.93 77 322834 6718 79414759
Protein S deficiency 29.67 9.93 14 322897 146 79421331
Colonic haematoma 29.67 9.93 12 322899 83 79421394
Drug tolerance decreased 29.50 9.93 8 322903 12970 79408507
Atheroembolism 29.45 9.93 18 322893 326 79421151
Atrial septal defect repair 29.34 9.93 20 322891 440 79421037
Emotional distress 29.17 9.93 75 322836 39894 79381583
Aspergillus infection 29.15 9.93 21 322890 19140 79402337
Hypokalaemia 29.15 9.93 409 322502 143631 79277846
Petechiae 29.09 9.93 162 322749 20403 79401074
Walking distance test abnormal 28.99 9.93 24 322887 714 79420763
Periorbital haematoma 28.88 9.93 27 322884 947 79420530
Heart rate increased 28.85 9.93 666 322245 120058 79301419
Systemic infection 28.76 9.93 3 322908 9749 79411728
Pneumonitis 28.44 9.93 138 322773 60722 79360755
Disability 28.43 9.93 17 322894 17103 79404374
Purpura 28.41 9.93 155 322756 19372 79402105
Ovarian haemorrhage 28.25 9.93 17 322894 299 79421178
Gravitational oedema 28.18 9.93 36 322875 1803 79419674
Osteopenia 28.10 9.93 20 322891 18344 79403133
Infusion site warmth 28.04 9.93 32 322879 1423 79420054
Drug eruption 27.97 9.93 88 322823 43847 79377630
Nephropathy 27.97 9.93 95 322816 9643 79411834
Vascular calcification 27.93 9.93 28 322883 1072 79420405
Pancreatitis 27.87 9.93 163 322748 68412 79353065
Central venous catheter removal 27.87 9.93 20 322891 479 79420998
Cerebellar haematoma 27.77 9.93 22 322889 614 79420863
Loss of consciousness 27.72 9.93 883 322028 167060 79254417
Dizziness exertional 27.55 9.93 21 322890 553 79420924
Breast necrosis 27.45 9.93 11 322900 74 79421403
Subdural haematoma evacuation 27.45 9.93 11 322900 74 79421403
Gastric antral vascular ectasia 27.34 9.93 26 322885 932 79420545
Sciatic nerve palsy 27.33 9.93 11 322900 75 79421402
Pericardial effusion 27.28 9.93 297 322614 45940 79375537
Chest tube insertion 27.27 9.93 13 322898 139 79421338
Extrapyramidal disorder 27.17 9.93 31 322880 22648 79398829
Catheter site vesicles 27.15 9.93 17 322894 322 79421155
Cytomegalovirus viraemia 27.15 9.93 9 322902 12812 79408665
Oxygen therapy 27.12 9.93 44 322867 2746 79418731
Blood urine present 27.02 9.93 163 322748 21134 79400343
Vascular device infection 26.71 9.93 97 322814 10179 79411298
Anaphylactic shock 26.69 9.93 67 322844 35929 79385548
Diffuse large B-cell lymphoma 26.67 9.93 8 322903 12141 79409336
Hypercalcaemia 26.62 9.93 74 322837 38356 79383121
Adjustment disorder with depressed mood 26.27 9.93 3 322908 9083 79412394
Depressed mood 26.25 9.93 104 322807 48376 79373101
Hallucination, auditory 26.22 9.93 27 322884 20666 79400811
Infusion site cellulitis 26.22 9.93 16 322895 289 79421188
Prostate cancer 26.19 9.93 60 322851 33208 79388269
Breast cancer female 26.17 9.93 7 322904 11454 79410023
Tremor 26.16 9.93 508 322403 169575 79251902
Crying 26.01 9.93 33 322878 23010 79398467
Drug reaction with eosinophilia and systemic symptoms 25.95 9.93 153 322758 64091 79357386
Dilatation ventricular 25.90 9.93 54 322857 4090 79417387
Thrombectomy 25.88 9.93 16 322895 296 79421181
Implant site haematoma 25.82 9.93 13 322898 158 79421319
Cardiac pacemaker replacement 25.81 9.93 19 322892 474 79421003
Irritability 25.78 9.93 83 322828 41061 79380416
Respiratory failure 25.76 9.93 935 321976 179976 79241501
Product storage error 25.73 9.93 17 322894 16209 79405268
Procedural haemorrhage 25.62 9.93 58 322853 4648 79416829
Disease recurrence 25.59 9.93 92 322819 44017 79377460
Neutropenic sepsis 25.45 9.93 44 322867 27020 79394457
Catheter site warmth 25.43 9.93 15 322896 254 79421223
Spinal cord haemorrhage 25.37 9.93 20 322891 554 79420923
Tumour lysis syndrome 25.28 9.93 36 322875 23903 79397574
Embolism 25.28 9.93 118 322793 13864 79407613
Nasopharyngitis 25.27 9.93 809 322102 253072 79168405
BK virus infection 25.23 9.93 3 322908 8801 79412676
Heart rate irregular 25.20 9.93 222 322689 32457 79389020
Hypertriglyceridaemia 25.18 9.93 10 322901 12730 79408747
Hepatic steatosis 25.16 9.93 74 322837 37664 79383813
Cor pulmonale 25.15 9.93 38 322873 2230 79419247
Cardiac valve disease 25.08 9.93 65 322846 5676 79415801
Renal vascular thrombosis 24.99 9.93 10 322901 67 79421410
Renal haematoma 24.96 9.93 23 322888 792 79420685
Calcium deficiency 24.90 9.93 24 322887 875 79420602
Acne 24.85 9.93 45 322866 27145 79394332
Neutrophil count increased 24.81 9.93 51 322860 29345 79392132
Blood potassium increased 24.75 9.93 203 322708 29072 79392405
Hypovolaemic shock 24.74 9.93 107 322804 12169 79409308
Pharyngeal haematoma 24.72 9.93 12 322899 134 79421343
Device breakage 24.63 9.93 97 322814 10578 79410899
Small intestinal haemorrhage 24.57 9.93 53 322858 4110 79417367
Cataract 24.53 9.93 149 322762 61971 79359506
Injection site rash 24.41 9.93 22 322889 17932 79403545
COVID-19 pneumonia 24.40 9.93 50 322861 28799 79392678
Epstein-Barr virus infection 24.39 9.93 14 322897 14402 79407075
Musculoskeletal pain 24.29 9.93 281 322630 102073 79319404
Injection site warmth 24.18 9.93 15 322896 14792 79406685
Blood viscosity decreased 24.15 9.93 10 322901 74 79421403
Unevaluable event 24.12 9.93 337 322574 55248 79366229
Tuberculosis 23.99 9.93 16 322895 15182 79406295
Panniculitis 23.98 9.93 10 322901 12361 79409116
Ventricular hyperkinesia 23.96 9.93 15 322896 284 79421193
Arteriovenous fistula site haemorrhage 23.91 9.93 16 322895 341 79421136
Adenovirus infection 23.91 9.93 3 322908 8444 79413033
Protein S decreased 23.89 9.93 11 322900 108 79421369
Abnormal behaviour 23.86 9.93 72 322839 36349 79385128
Epilepsy 23.85 9.93 85 322826 40775 79380702
Hyperbilirubinaemia 23.85 9.93 39 322872 24479 79396998
Femoral nerve palsy 23.81 9.93 10 322901 77 79421400
Left ventricular failure 23.70 9.93 89 322822 9492 79411985
Glomerular filtration rate 23.68 9.93 12 322899 148 79421329
Migraine 23.67 9.93 233 322678 87260 79334217
Uveitis 23.63 9.93 20 322891 16810 79404667
Blood pressure systolic abnormal 23.61 9.93 21 322890 17226 79404251
Dry mouth 23.56 9.93 235 322676 87784 79333693
Ischaemic stroke 23.48 9.93 221 322690 32910 79388567
Encephalopathy 23.42 9.93 168 322743 67229 79354248
Apallic syndrome 23.41 9.93 24 322887 944 79420533
Therapeutic response shortened 23.34 9.93 18 322893 15845 79405632
Chills 23.32 9.93 483 322428 159751 79261726
Hypoxia 23.27 9.93 565 322346 102678 79318799
Withdrawal syndrome 23.17 9.93 46 322865 26808 79394669
Carpal tunnel syndrome 23.07 9.93 27 322884 19501 79401976
Substance abuse 22.98 9.93 7 322904 10519 79410958
Multiple-drug resistance 22.92 9.93 4 322907 8804 79412673
Incision site haemorrhage 22.84 9.93 25 322886 1061 79420416
Blood culture negative 22.79 9.93 13 322898 206 79421271
Heart valve operation 22.79 9.93 13 322898 206 79421271
Metastases to bone 22.70 9.93 40 322871 24387 79397090
Blood pressure systolic decreased 22.68 9.93 97 322814 10979 79410498
Thrombotic microangiopathy 22.65 9.93 29 322882 20140 79401337
Haemorrhagic arteriovenous malformation 22.65 9.93 19 322892 576 79420901
Device difficult to use 22.64 9.93 13 322898 13372 79408105
Rash erythematous 22.59 9.93 139 322772 57630 79363847
Tongue haemorrhage 22.58 9.93 24 322887 985 79420492
Pneumonia aspiration 22.56 9.93 389 322522 66578 79354899
Hypertransaminasaemia 22.54 9.93 10 322901 11914 79409563
Iris haemorrhage 22.47 9.93 6 322905 7 79421470
Influenza like illness 22.44 9.93 184 322727 71523 79349954
Haemorrhagic cholecystitis 22.19 9.93 10 322901 93 79421384
Infusion site irritation 22.10 9.93 21 322890 752 79420725
Haemorrhagic infarction 22.08 9.93 21 322890 753 79420724
Live birth 22.05 9.93 26 322885 18718 79402759
Renal failure 22.01 9.93 1010 321901 199958 79221519
Urinary bladder haemorrhage 21.99 9.93 38 322873 2498 79418979
Pneumonia 21.97 9.93 3022 319889 657224 78764253
Adverse event 21.95 9.93 148 322763 60066 79361411
Mood swings 21.90 9.93 29 322882 19851 79401626
Skin weeping 21.85 9.93 24 322887 1023 79420454
Platelet distribution width increased 21.82 9.93 11 322900 134 79421343
Abortion spontaneous 21.82 9.93 55 322856 29452 79392025
Angioplasty 21.79 9.93 32 322879 1831 79419646
Transplant rejection 21.77 9.93 28 322883 19409 79402068
Haemorrhagic ascites 21.74 9.93 14 322897 279 79421198
Myocarditis 21.67 9.93 34 322877 21699 79399778
Paracentesis 21.67 9.93 27 322884 1318 79420159
Catheter site dermatitis 21.56 9.93 10 322901 100 79421377
Cardiac flutter 21.55 9.93 56 322855 4898 79416579
Intraocular haematoma 21.50 9.93 7 322904 23 79421454
Pleural effusion 21.48 9.93 754 322157 144508 79276969
Tumour haemorrhage 21.37 9.93 50 322861 4094 79417383
Psychomotor hyperactivity 21.33 9.93 22 322889 16827 79404650
Jugular vein distension 21.31 9.93 28 322883 1442 79420035
Arteriovenous graft site haemorrhage 21.24 9.93 6 322905 10 79421467
Feeling hot 21.19 9.93 148 322763 59586 79361891
Haemorrhagic cerebral infarction 21.17 9.93 28 322883 1451 79420026
Blood pressure diastolic abnormal 21.16 9.93 28 322883 19174 79402303
Infusion site oedema 21.14 9.93 22 322889 881 79420596
Liver function test increased 21.11 9.93 86 322825 39687 79381790
Drug withdrawal syndrome 21.09 9.93 71 322840 34647 79386830
Endocarditis 21.08 9.93 92 322819 10505 79410972
Transaminases increased 21.02 9.93 123 322788 51620 79369857
Extrasystoles 20.98 9.93 72 322839 7347 79414130
Urinary bladder rupture 20.89 9.93 10 322901 108 79421369
Pericarditis uraemic 20.88 9.93 6 322905 11 79421466
Ubiquinone decreased 20.84 9.93 7 322904 26 79421451
Oral mucosa haematoma 20.73 9.93 8 322903 48 79421429
Hip fracture 20.72 9.93 203 322708 30558 79390919
Coeliac disease 20.71 9.93 10 322901 11341 79410136
Aspiration pleural cavity 20.71 9.93 29 322882 1588 79419889
Catarrh 20.70 9.93 34 322877 2144 79419333
Status epilepticus 20.67 9.93 44 322867 24997 79396480
Factor V inhibition 20.66 9.93 15 322896 366 79421111
Throat tightness 20.65 9.93 52 322859 27855 79393622
Fat embolism 20.65 9.93 16 322895 432 79421045
Hepatic failure 20.59 9.93 154 322757 61058 79360419
Oral candidiasis 20.56 9.93 57 322854 29571 79391906
Prothrombin level increased 20.49 9.93 16 322895 437 79421040
Blood blister 20.48 9.93 41 322870 3016 79418461
Ovarian rupture 20.44 9.93 7 322904 28 79421449
Haemobilia 20.39 9.93 17 322894 511 79420966
Heart sounds abnormal 20.32 9.93 27 322884 1406 79420071
Hepatic haematoma 20.20 9.93 21 322890 840 79420637
Pathogen resistance 20.19 9.93 17 322894 14325 79407152
Right atrial enlargement 20.18 9.93 15 322896 380 79421097
Dyskinesia 20.07 9.93 103 322808 44670 79376807
Hypogammaglobulinaemia 19.96 9.93 14 322897 12937 79408540
Lacrimal haemorrhage 19.88 9.93 7 322904 31 79421446
Nasal polyps 19.80 9.93 3 322908 7324 79414153
Pulmonary haematoma 19.75 9.93 10 322901 123 79421354
Burns second degree 19.75 9.93 37 322874 2591 79418886
Dermatitis atopic 19.70 9.93 8 322903 10048 79411429
Accidental overdose 19.68 9.93 246 322665 39335 79382142
Right ventricular dysfunction 19.68 9.93 37 322874 2598 79418879
Heart transplant 19.62 9.93 27 322884 1454 79420023
Injection site urticaria 19.59 9.93 14 322897 12812 79408665
Poisoning 19.56 9.93 46 322865 25226 79396251
Livedo reticularis 19.54 9.93 48 322863 4055 79417422
Procedural pain 19.53 9.93 40 322871 23044 79398433
Ulcer haemorrhage 19.53 9.93 60 322851 5778 79415699
Protein C deficiency 19.53 9.93 7 322904 33 79421444
Candida infection 19.43 9.93 84 322827 38130 79383347
Transplant dysfunction 19.41 9.93 3 322908 7218 79414259
Multiple sclerosis 19.37 9.93 38 322873 22244 79399233
Prothrombin level abnormal 19.36 9.93 11 322900 173 79421304
Chordae tendinae rupture 19.34 9.93 8 322903 59 79421418
Catheter site mass 19.34 9.93 8 322903 59 79421418
Xanthopsia 19.30 9.93 14 322897 341 79421136
Paradoxical drug reaction 19.28 9.93 3 322908 7182 79414295
Splenic rupture 19.26 9.93 35 322876 2394 79419083
Haemorrhagic ovarian cyst 19.24 9.93 18 322893 632 79420845
Cardiotoxicity 19.17 9.93 13 322898 12226 79409251
Hyperglycaemia 19.15 9.93 187 322724 70148 79351329
Post procedural haematoma 19.13 9.93 35 322876 2407 79419070
Intervertebral disc protrusion 19.09 9.93 42 322869 23579 79397898
Iron deficiency anaemia 19.08 9.93 173 322738 25499 79395978
Osteonecrosis of jaw 19.06 9.93 100 322811 43126 79378351
Food allergy 19.05 9.93 10 322901 10814 79410663
Anastomotic infection 19.00 9.93 10 322901 134 79421343
Eschar 18.94 9.93 25 322886 1293 79420184
N-terminal prohormone brain natriuretic peptide increased 18.92 9.93 52 322859 4703 79416774
Adrenal insufficiency 18.89 9.93 56 322855 28431 79393046
Chronic sinusitis 18.89 9.93 15 322896 13011 79408466
Gait disturbance 18.82 9.93 669 322242 206837 79214640
Adverse drug reaction 18.72 9.93 175 322736 66217 79355260
Medical device site haematoma 18.72 9.93 7 322904 38 79421439
Catheter site dryness 18.72 9.93 7 322904 38 79421439
Creatinine renal clearance decreased 18.69 9.93 30 322881 18972 79402505
Cardiac ventricular thrombosis 18.67 9.93 29 322882 1744 79419733
Polyneuropathy 18.66 9.93 44 322867 24107 79397370
Thyroid haemorrhage 18.66 9.93 9 322902 99 79421378
Large intestine polyp 18.57 9.93 101 322810 12607 79408870
Right ventricular enlargement 18.48 9.93 18 322893 665 79420812
Erythema 18.45 9.93 728 322183 222562 79198915
Exposure to toxic agent 18.41 9.93 7 322904 9151 79412326
Blood pressure diastolic increased 18.40 9.93 19 322892 14523 79406954
Vitamin K decreased 18.37 9.93 8 322903 68 79421409
Akathisia 18.32 9.93 16 322895 13243 79408234
Hyperthyroidism 18.24 9.93 153 322758 22056 79399421
Labelled drug-disease interaction medication error 18.09 9.93 13 322898 312 79421165
Wound haemorrhage 18.07 9.93 47 322864 4114 79417363
Infusion site discharge 18.03 9.93 17 322894 603 79420874
Gastrointestinal erosion 17.95 9.93 22 322889 1056 79420421
Anger 17.94 9.93 26 322885 17136 79404341
Ear infection 17.93 9.93 75 322836 34357 79387120
Hernia repair 17.84 9.93 31 322880 2047 79419430
Prothrombin time shortened 17.81 9.93 40 322871 3188 79418289
Cardiomegaly 17.79 9.93 174 322737 26178 79395299
Peripheral sensory neuropathy 17.68 9.93 16 322895 13017 79408460
Cholecystitis chronic 17.66 9.93 9 322902 9897 79411580
No adverse event 17.57 9.93 84 322827 37108 79384369
Weight increased 17.53 9.93 931 321980 276455 79145022
Prothrombin level decreased 17.46 9.93 27 322884 1617 79419860
Blood pressure systolic increased 17.45 9.93 180 322731 66806 79354671
Injection site discharge 17.43 9.93 19 322892 803 79420674
Skin exfoliation 17.42 9.93 141 322770 54959 79366518
Alanine aminotransferase increased 17.40 9.93 513 322398 162057 79259420
Brain stem haemorrhage 17.39 9.93 27 322884 1623 79419854
Upper airway obstruction 17.38 9.93 25 322886 1403 79420074
Joint dislocation 17.37 9.93 26 322885 16913 79404564
Infusion site abscess 17.36 9.93 11 322900 213 79421264
Drug specific antibody present 17.35 9.93 3 322908 6649 79414828
Upper respiratory tract infection 17.34 9.93 262 322649 90906 79330571
Spinal osteoarthritis 17.34 9.93 26 322885 16901 79404576
Device physical property issue 17.29 9.93 35 322876 2595 79418882
Colitis ulcerative 17.28 9.93 77 322834 34665 79386812
Cerebral artery embolism 17.28 9.93 29 322882 1862 79419615
Thoracic haemorrhage 17.27 9.93 11 322900 215 79421262
Agranulocytosis 17.27 9.93 109 322802 44921 79376556
Right ventricular diastolic collapse 17.25 9.93 8 322903 80 79421397
Pulmonary arterial pressure abnormal 17.23 9.93 18 322893 724 79420753
Back pain 17.21 9.93 1032 321879 303148 79118329
Burning sensation 17.20 9.93 153 322758 58479 79362998
Implantable defibrillator replacement 17.11 9.93 5 322906 10 79421467
Refusal of treatment by patient 17.09 9.93 77 322834 8914 79412563
Sickle cell anaemia 17.04 9.93 17 322894 647 79420830
Mitral valve thickening 17.01 9.93 14 322897 413 79421064
Mitral valve repair 16.95 9.93 12 322899 281 79421196
Catheter site nodule 16.88 9.93 7 322904 52 79421425
Diabetes mellitus 16.79 9.93 220 322691 78170 79343307
Colorectal cancer 16.75 9.93 7 322904 8640 79412837
Synovial cyst 16.71 9.93 10 322901 10055 79411422
Acute hepatic failure 16.69 9.93 64 322847 30049 79391428
Puncture site haematoma 16.66 9.93 10 322901 175 79421302
Nephrosclerosis 16.63 9.93 28 322883 1802 79419675
Ovarian cyst 16.62 9.93 16 322895 12639 79408838
Proctalgia 16.51 9.93 10 322901 9991 79411486
Hemiparesis 16.49 9.93 209 322702 33524 79387953
Hyponatraemic syndrome 16.48 9.93 18 322893 762 79420715
Haemorrhage urinary tract 16.48 9.93 33 322878 2428 79419049
Pulmonary calcification 16.48 9.93 14 322897 432 79421045
Hypochromasia 16.37 9.93 17 322894 679 79420798
Demyelination 16.35 9.93 6 322905 8017 79413460
Progressive multifocal leukoencephalopathy 16.34 9.93 37 322874 20563 79400914
Cardiac murmur 16.34 9.93 115 322796 15709 79405768
Anal fistula 16.32 9.93 4 322907 6940 79414537
Body temperature increased 16.28 9.93 109 322802 44311 79377166
Ulnar nerve palsy 16.21 9.93 5 322906 13 79421464
Lip haemorrhage 16.17 9.93 22 322889 1172 79420305
Breast cancer 16.13 9.93 76 322835 33705 79387772
Glaucoma 16.08 9.93 35 322876 19726 79401751
Scleroderma 16.04 9.93 54 322857 5456 79416021
Angiodysplasia 15.99 9.93 21 322890 1081 79420396
Oliguria 15.96 9.93 117 322794 16192 79405285
Delusion 15.94 9.93 37 322874 20386 79401091
Mitral valve stenosis 15.94 9.93 22 322889 1188 79420289
Catheter site oedema 15.90 9.93 8 322903 97 79421380
Venous thrombosis 15.89 9.93 64 322847 7052 79414425
Mitral valve disease 15.87 9.93 38 322873 3159 79418318
Craniotomy 15.84 9.93 14 322897 456 79421021
Tongue disorder 15.79 9.93 20 322891 13955 79407522
Oesophageal ulcer 15.79 9.93 63 322848 6912 79414565
Oesophageal carcinoma 15.78 9.93 13 322898 11071 79410406
Metastases to lung 15.77 9.93 31 322880 18132 79403345
Cardioactive drug level below therapeutic 15.70 9.93 5 322906 15 79421462
Bone pain 15.69 9.93 147 322764 55595 79365882
Cardiac failure high output 15.68 9.93 12 322899 318 79421159
Incision site haematoma 15.65 9.93 9 322902 145 79421332
Post transplant lymphoproliferative disorder 15.64 9.93 14 322897 11450 79410027
Catheter site erosion 15.64 9.93 7 322904 64 79421413
Hemianopia homonymous 15.63 9.93 23 322888 1318 79420159
Atrioventricular block complete 15.60 9.93 118 322793 16492 79404985
Coronary artery bypass 15.57 9.93 57 322854 6005 79415472
Abdominal cavity drainage 15.57 9.93 18 322893 812 79420665
Large intestinal ulcer haemorrhage 15.55 9.93 12 322899 322 79421155
Encephalomalacia 15.51 9.93 22 322889 1219 79420258
Intervertebral disc degeneration 15.45 9.93 25 322886 15760 79405717
Oral disorder 15.44 9.93 11 322900 10084 79411393
Abdominal pain upper 15.33 9.93 745 322166 223074 79198403
Coma scale normal 15.30 9.93 4 322907 4 79421473
Low cardiac output syndrome 15.30 9.93 20 322891 1025 79420452
Klebsiella infection 15.29 9.93 25 322886 15695 79405782
Cardiac output increased 15.27 9.93 11 322900 265 79421212
Odynophagia 15.26 9.93 14 322897 11313 79410164
Cardiac output decreased 15.24 9.93 27 322884 1811 79419666
Liver abscess 15.21 9.93 3 322908 6051 79415426
Blood viscosity increased 15.17 9.93 12 322899 334 79421143
Visual impairment 15.14 9.93 272 322639 91859 79329618
Chronic respiratory failure 15.08 9.93 36 322875 2986 79418491
Metastases to central nervous system 15.05 9.93 27 322884 16348 79405129
Coagulation factor deficiency 15.02 9.93 9 322902 157 79421320
Gastrointestinal toxicity 15.02 9.93 7 322904 8102 79413375
Application site irritation 14.95 9.93 26 322885 1718 79419759
Ovarian cyst ruptured 14.94 9.93 19 322892 947 79420530
Device adhesion issue 14.92 9.93 5 322906 7070 79414407
N-telopeptide urine increased 14.90 9.93 6 322905 41 79421436
Aortic bruit 14.89 9.93 11 322900 276 79421201
Dermatitis allergic 14.85 9.93 32 322879 18098 79403379
Subcapsular renal haematoma 14.83 9.93 17 322894 760 79420717
Balloon atrial septostomy 14.77 9.93 8 322903 114 79421363
Muscle rigidity 14.75 9.93 37 322874 19845 79401632
Renal disorder 14.69 9.93 246 322665 41859 79379618
Parkinsonism 14.66 9.93 28 322883 16556 79404921
Injection site mass 14.63 9.93 38 322873 20146 79401331
Liver function test abnormal 14.57 9.93 353 322558 64122 79357355
Anal abscess 14.56 9.93 10 322901 9345 79412132
Left atrial enlargement 14.56 9.93 21 322890 1182 79420295
Device related thrombosis 14.53 9.93 33 322878 2650 79418827
Neutrophilia 14.52 9.93 7 322904 7944 79413533
Aphasia 14.51 9.93 268 322643 46464 79375013
Arteriovenous fistula operation 14.49 9.93 12 322899 357 79421120
Dry skin 14.49 9.93 191 322720 67804 79353673
Alanine aminotransferase abnormal 14.45 9.93 9 322902 8858 79412619
Depressed level of consciousness 14.45 9.93 290 322621 96362 79325115
Alkalosis hypokalaemic 14.41 9.93 5 322906 21 79421456
Blood uric acid increased 14.33 9.93 98 322813 13262 79408215
Skin reaction 14.32 9.93 27 322884 16041 79405436
Aneurysm 14.31 9.93 39 322872 3509 79417968
Implantable defibrillator insertion 14.27 9.93 19 322892 991 79420486
Herpes simplex 14.23 9.93 17 322894 12170 79409307
Dyspnoea at rest 14.23 9.93 63 322848 7239 79414238
Vaginal haemorrhage 14.22 9.93 143 322768 21674 79399803
Affective disorder 14.19 9.93 8 322903 8311 79413166
Euglycaemic diabetic ketoacidosis 14.15 9.93 5 322906 6839 79414638
Muscle twitching 14.13 9.93 52 322859 24712 79396765
Aplasia 14.10 9.93 7 322904 7813 79413664
Aortic valve incompetence 14.10 9.93 76 322835 9454 79412023
SARS-CoV-2 test positive 14.05 9.93 16 322895 11700 79409777
Medical device site haemorrhage 14.04 9.93 9 322902 178 79421299
Gastrointestinal ulcer 14.02 9.93 38 322873 3408 79418069
Muscle strain 14.00 9.93 76 322835 9479 79411998
Peptic ulcer 13.92 9.93 56 322855 6167 79415310
Procalcitonin abnormal 13.92 9.93 12 322899 378 79421099
Metastases to lymph nodes 13.83 9.93 13 322898 10384 79411093
Incarcerated hernia 13.81 9.93 12 322899 382 79421095
Haemodialysis 13.79 9.93 123 322788 18045 79403432
Paraesthesia oral 13.75 9.93 40 322871 20431 79401046
Splenic haematoma 13.73 9.93 11 322900 312 79421165
Tricuspid valve incompetence 13.72 9.93 131 322780 19581 79401896
Intestinal haemorrhage 13.72 9.93 57 322854 6369 79415108
Polyomavirus-associated nephropathy 13.70 9.93 3 322908 5624 79415853
Cardioactive drug level above therapeutic 13.70 9.93 10 322901 246 79421231
Left ventricular enlargement 13.69 9.93 16 322895 730 79420747
Strangury 13.69 9.93 9 322902 186 79421291
Multiple injuries 13.69 9.93 38 322873 3457 79418020
Breast cancer stage I 13.68 9.93 5 322906 6695 79414782
Dysphagia 13.67 9.93 383 322528 121753 79299724
Stress cardiomyopathy 13.67 9.93 15 322896 11151 79410326
Retching 13.64 9.93 119 322792 17348 79404129
Vaginal haematoma 13.64 9.93 8 322903 134 79421343
Nocturnal dyspnoea 13.63 9.93 24 322887 1602 79419875
Mitral valve incompetence 13.55 9.93 176 322735 28389 79393088
Congenital tracheomalacia 13.54 9.93 3 322908 0 79421477
Application site pruritus 13.54 9.93 40 322871 3770 79417707
Colon cancer 13.54 9.93 103 322808 14420 79407057
Eye infection 13.53 9.93 17 322894 11903 79409574
Gastrointestinal pain 13.49 9.93 12 322899 9843 79411634
Cardioactive drug level decreased 13.48 9.93 9 322902 191 79421286
Gastrointestinal angiodysplasia 13.43 9.93 19 322892 1050 79420427
IgA nephropathy 13.42 9.93 25 322886 1743 79419734
Micturition urgency 13.36 9.93 19 322892 12622 79408855
Bullous haemorrhagic dermatosis 13.36 9.93 7 322904 93 79421384
Arterial haemorrhage 13.32 9.93 31 322880 2530 79418947
Nodule 13.31 9.93 48 322863 22946 79398531
Radiation proctitis 13.28 9.93 8 322903 141 79421336
Stent placement 13.27 9.93 57 322854 6463 79415014
Herpes virus infection 13.19 9.93 6 322905 7043 79414434
Cervical cord compression 13.17 9.93 12 322899 407 79421070
Diabetes mellitus inadequate control 13.17 9.93 52 322859 24212 79397265
Purple glove syndrome 13.16 9.93 10 322901 262 79421215
Circulatory collapse 13.12 9.93 220 322691 37448 79384029
Headache 13.11 9.93 2914 319997 650858 78770619
Gastrointestinal angiectasia 13.00 9.93 12 322899 414 79421063
Female genital tract fistula 13.00 9.93 4 322907 5971 79415506
Treatment noncompliance 12.99 9.93 290 322621 51978 79369499
Joint effusion 12.99 9.93 34 322877 17980 79403497
Drain placement 12.99 9.93 8 322903 147 79421330
Application site odour 12.96 9.93 5 322906 30 79421447
Mydriasis 12.96 9.93 33 322878 17610 79403867
Intra-abdominal fluid collection 12.93 9.93 35 322876 3137 79418340
Haematoma infection 12.90 9.93 23 322888 1550 79419927
Blood cholinesterase decreased 12.87 9.93 10 322901 271 79421206
Venous haemorrhage 12.85 9.93 11 322900 343 79421134
Investigation 12.82 9.93 29 322882 2322 79419155
Heartland virus infection 12.82 9.93 5 322906 31 79421446
Uterine haemorrhage 12.82 9.93 33 322878 2870 79418607
Human herpesvirus 6 infection 12.80 9.93 3 322908 5367 79416110
Hypopnoea 12.77 9.93 49 322862 5280 79416197
Ketoacidosis 12.76 9.93 8 322903 7846 79413631
Disease progression 12.76 9.93 613 322298 183749 79237728
Hepatic rupture 12.73 9.93 7 322904 103 79421374
Neuralgia 12.70 9.93 81 322830 33303 79388174
Sopor 12.69 9.93 196 322715 32814 79388663
Catheter site urticaria 12.69 9.93 5 322906 32 79421445
Cerebellar infarction 12.68 9.93 38 322873 3609 79417868
Vaginal infection 12.68 9.93 4 322907 5876 79415601
Myocardial infarction 12.66 9.93 887 322024 183242 79238235
Hepatic infarction 12.61 9.93 17 322894 898 79420579
Blepharospasm 12.58 9.93 4 322907 5847 79415630
Ischaemic hepatitis 12.58 9.93 38 322873 3626 79417851
Exophthalmos 12.56 9.93 24 322887 1706 79419771
Valvuloplasty cardiac 12.56 9.93 4 322907 12 79421465
Procalcitonin 12.56 9.93 4 322907 12 79421465
Arterial rupture 12.54 9.93 16 322895 800 79420677
Skin fissures 12.52 9.93 21 322890 13052 79408425
X-ray abnormal 12.45 9.93 4 322907 5809 79415668
Coagulation factor decreased 12.42 9.93 9 322902 219 79421258
Behaviour disorder 12.41 9.93 5 322906 6308 79415169
Mental disorder 12.40 9.93 75 322836 31227 79390250
Enterocolitis 12.40 9.93 25 322886 14487 79406990
Pelvic haemorrhage 12.40 9.93 8 322903 160 79421317
Bovine tuberculosis 12.40 9.93 8 322903 160 79421317
Protein-losing gastroenteropathy 12.39 9.93 14 322897 616 79420861
Rehabilitation therapy 12.37 9.93 25 322886 1852 79419625
Memory impairment 12.35 9.93 351 322560 111383 79310094
Disease complication 12.33 9.93 46 322865 4891 79416586
Hemiplegia 12.31 9.93 103 322808 14836 79406641
Renal infarct 12.31 9.93 31 322880 2660 79418817
Proteinuria 12.29 9.93 79 322832 32423 79389054
Eyelid ptosis 12.28 9.93 16 322895 11028 79410449
Granulocytopenia 12.26 9.93 17 322894 11414 79410063
Intracranial haematoma 12.25 9.93 17 322894 923 79420554
Hernia hiatus repair 12.21 9.93 6 322905 69 79421408
Cytopenia 12.17 9.93 42 322869 20341 79401136
Medication error 12.14 9.93 364 322547 68278 79353199
Encephalitis 12.13 9.93 26 322885 14734 79406743
Vomiting 12.08 9.93 2446 320465 663382 78758095
Oropharyngeal discomfort 12.06 9.93 7 322904 7159 79414318
Prostatic haemorrhage 12.06 9.93 8 322903 168 79421309
Mania 12.03 9.93 36 322875 18224 79403253
Aortic aneurysm rupture 12.02 9.93 20 322891 1275 79420202
Increased tendency to bruise 11.97 9.93 78 322833 10386 79411091
Mucormycosis 11.97 9.93 10 322901 8459 79413018
Stent-graft endoleak 11.96 9.93 5 322906 38 79421439
Pseudomonal sepsis 11.95 9.93 5 322906 6169 79415308
Therapy interrupted 11.95 9.93 76 322835 31265 79390212
Right ventricular systolic pressure increased 11.94 9.93 17 322894 945 79420532
Chronic cutaneous lupus erythematosus 11.91 9.93 12 322899 462 79421015
Dental pulp disorder 11.88 9.93 4 322907 15 79421462
Personality disorder 11.86 9.93 5 322906 6141 79415336
Blood potassium decreased 11.86 9.93 259 322652 46253 79375224
Vena cava thrombosis 11.86 9.93 32 322879 2863 79418614
Abnormal loss of weight 11.86 9.93 66 322845 8310 79413167
Photophobia 11.78 9.93 43 322868 20485 79400992
Hepatic encephalopathy 11.76 9.93 54 322857 24112 79397365
Premature labour 11.75 9.93 10 322901 8380 79413097
Diastolic hypotension 11.74 9.93 8 322903 176 79421301
Antiphospholipid antibodies positive 11.71 9.93 15 322896 753 79420724
Mediastinal haemorrhage 11.70 9.93 6 322905 76 79421401
Emergency care examination 11.69 9.93 7 322904 122 79421355
Pre-eclampsia 11.68 9.93 7 322904 7034 79414443
Metastases to liver 11.66 9.93 67 322844 28247 79393230
Spinal cord compression 11.66 9.93 54 322857 6323 79415154
Traumatic haemorrhage 11.59 9.93 20 322891 1313 79420164
Injection site bruising 11.59 9.93 108 322803 40894 79380583
Hepatitis B 11.58 9.93 10 322901 8322 79413155
Fibrinous bronchitis 11.53 9.93 5 322906 42 79421435
Blood pressure immeasurable 11.53 9.93 26 322885 2078 79419399
Scrotal oedema 11.52 9.93 22 322889 1563 79419914
Product complaint 11.52 9.93 93 322818 13256 79408221
Cushingoid 11.51 9.93 13 322898 9539 79411938
5-hydroxyindolacetic acid increased 11.49 9.93 4 322907 17 79421460
Localised oedema 11.49 9.93 63 322848 7889 79413588
Biliary tract operation 11.47 9.93 3 322908 3 79421474
Optic neuritis 11.42 9.93 13 322898 9507 79411970
Cytomegalovirus chorioretinitis 11.37 9.93 4 322907 5486 79415991
Arteriovenous fistula 11.37 9.93 20 322891 1334 79420143
Eosinophilia 11.34 9.93 123 322788 45222 79376255
Hepatic vein thrombosis 11.33 9.93 9 322902 252 79421225
Bladder necrosis 11.31 9.93 4 322907 18 79421459
Emotional disorder 11.28 9.93 26 322885 14361 79407116
Malignant melanoma 11.27 9.93 27 322884 14714 79406763
Product dose omission in error 11.25 9.93 9 322902 7779 79413698
Haemorrhoids 11.22 9.93 173 322738 28955 79392522
Electrolyte imbalance 11.21 9.93 76 322835 30805 79390672
Heart and lung transplant 11.21 9.93 8 322903 190 79421287
Nephrogenic systemic fibrosis 11.15 9.93 52 322859 6108 79415369
Stevens-Johnson syndrome 11.14 9.93 103 322808 39063 79382414
Coagulation factor V level increased 11.14 9.93 5 322906 46 79421431
Mitral perforation 11.13 9.93 4 322907 19 79421458
Peripheral ischaemia 11.13 9.93 71 322840 9386 79412091
Myoclonus 11.10 9.93 66 322845 27594 79393883
Thyroiditis acute 11.10 9.93 8 322903 193 79421284
Gastrointestinal polyp haemorrhage 11.09 9.93 12 322899 503 79420974
Respiratory arrest 11.08 9.93 165 322746 57385 79364092
Tardive dyskinesia 11.06 9.93 16 322895 10555 79410922
Injection site pustule 11.05 9.93 6 322905 86 79421391
Blood urine 11.04 9.93 16 322895 904 79420573
Personality change 11.03 9.93 15 322896 10155 79411322
Acquired oesophageal web 11.03 9.93 10 322901 337 79421140
Heart disease congenital 11.03 9.93 13 322898 599 79420878
Vessel puncture site haemorrhage 10.99 9.93 8 322903 196 79421281
Burning feet syndrome 10.99 9.93 8 322903 196 79421281
Complication of device insertion 10.98 9.93 6 322905 6344 79415133
Inadequate diet 10.98 9.93 9 322902 264 79421213
Amenorrhoea 10.98 9.93 9 322902 7683 79413794
Concomitant disease aggravated 10.97 9.93 91 322820 13076 79408401
Post procedural complication 10.96 9.93 146 322765 23683 79397794
Skin discolouration 10.95 9.93 230 322681 40804 79380673
Lip injury 10.93 9.93 18 322893 1138 79420339
Salivary hypersecretion 10.92 9.93 26 322885 14198 79407279
Dysaesthesia 10.91 9.93 5 322906 5843 79415634
Polyp 10.90 9.93 63 322848 8044 79413433
Septic shock 10.88 9.93 397 322514 122404 79299073
Hyperthermia 10.88 9.93 37 322874 18000 79403477
Affect lability 10.86 9.93 18 322893 11241 79410236
Anaesthesia 10.86 9.93 12 322899 515 79420962
Femoral artery aneurysm 10.85 9.93 8 322903 200 79421277
Thyrotoxic crisis 10.82 9.93 19 322892 1265 79420212
Diuretic therapy 10.82 9.93 8 322903 201 79421276
Infusion site pruritus 10.81 9.93 39 322872 4079 79417398
Libido decreased 10.81 9.93 4 322907 5317 79416160
Thromboembolectomy 10.81 9.93 6 322905 90 79421387
Tendon disorder 10.77 9.93 8 322903 7178 79414299
Therapeutic procedure 10.74 9.93 15 322896 819 79420658
Urine output decreased 10.74 9.93 116 322795 17906 79403571
Inhibitory drug interaction 10.71 9.93 41 322870 4412 79417065
Hallucination, visual 10.69 9.93 83 322828 32646 79388831
Bronchospasm 10.69 9.93 58 322853 24801 79396676
Device dislocation 10.69 9.93 156 322755 25814 79395663
Cardiac infection 10.68 9.93 11 322900 435 79421042
Drug dose omission by device 10.67 9.93 6 322905 6244 79415233
Parathyroid gland operation 10.66 9.93 4 322907 22 79421455
Vision blurred 10.63 9.93 337 322574 105561 79315916
Central nervous system lesion 10.61 9.93 24 322887 13344 79408133
Colonoscopy 10.60 9.93 24 322887 1923 79419554
Dysuria 10.54 9.93 144 322767 50807 79370670
Spinal fusion surgery 10.54 9.93 4 322907 5234 79416243
Bladder cancer 10.50 9.93 42 322869 19484 79401993
Cystitis haemorrhagic 10.49 9.93 13 322898 9159 79412318
Fistula 10.46 9.93 23 322888 12917 79408560
Peripheral embolism 10.45 9.93 24 322887 1942 79419535
Brain natriuretic peptide 10.44 9.93 5 322906 54 79421423
Drug therapy 10.42 9.93 18 322893 1183 79420294
Catheter site extravasation 10.42 9.93 11 322900 448 79421029
Dysentery 10.41 9.93 18 322893 1184 79420293
Delirium 10.36 9.93 262 322649 84365 79337112
Post thrombotic syndrome 10.35 9.93 13 322898 640 79420837
Blood glucose increased 10.35 9.93 371 322540 114604 79306873
Aortic aneurysm 10.31 9.93 64 322847 8382 79413095
Laryngitis 10.30 9.93 32 322879 16007 79405470
Respiratory tract infection 10.29 9.93 137 322774 48552 79372925
Subileus 10.29 9.93 5 322906 5649 79415828
Postpartum venous thrombosis 10.27 9.93 3 322908 6 79421471
Factor II mutation 10.27 9.93 3 322908 6 79421471
Acquired Von Willebrand's disease 10.27 9.93 3 322908 6 79421471
Acquired cardiac septal defect 10.27 9.93 3 322908 6 79421471
Cerebellar embolism 10.27 9.93 3 322908 6 79421471
Budd-Chiari syndrome 10.25 9.93 6 322905 100 79421377
Onychomycosis 10.22 9.93 11 322900 8250 79413227
Acquired phimosis 10.21 9.93 5 322906 57 79421420
Hernia obstructive 10.20 9.93 6 322905 101 79421376
Coagulation time abnormal 10.20 9.93 8 322903 220 79421257
Immunosuppression 10.15 9.93 23 322888 12780 79408697
Malaise 10.15 9.93 2187 320724 487682 78933795
Panic attack 10.14 9.93 57 322854 24159 79397318
Coordination abnormal 10.11 9.93 36 322875 17276 79404201
Tricuspid valve replacement 10.10 9.93 4 322907 26 79421451
Tricuspid valve repair 10.10 9.93 4 322907 26 79421451
Breast haemorrhage 10.07 9.93 7 322904 159 79421318
Basal ganglia haematoma 10.06 9.93 5 322906 59 79421418
Nerve injury 10.04 9.93 14 322897 9378 79412099
Eye haematoma 10.00 9.93 7 322904 161 79421316
Pulmonary resection 9.99 9.93 5 322906 60 79421417

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AA03 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Vitamin K antagonists
FDA EPC N0000175476 Vitamin K Antagonist
CHEBI has role CHEBI:33288 rodenticides
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:50390 NAD(P)H dehydrogenase (quinone) inhibitors
CHEBI has role CHEBI:55347 vitamin K antagonists
FDA MoA N0000175964 Vitamin K Inhibitors
MeSH PA D000925 Anticoagulants
MeSH PA D006401 Hematologic Agents
MeSH PA D010575 Pesticides
MeSH PA D012378 Rodenticides

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cerebral embolism indication 75543006 DOID:4372
Deep venous thrombosis indication 128053003
Pulmonary thromboembolism indication 233935004
Thromboembolic disorder indication 371039008
Thrombosis indication 439127006
Prevention of deep vein thrombosis indication 439993001
Thromboembolism due to Prosthetic Heart Valves indication
Myocardial Reinfarction Prevention indication
Prevention of Thromboembolism with Chronic Atrial Fibrillation indication
Deep Vein Thrombosis with Pulmonary Embolism indication
Pulmonary Thromboembolism Prevention indication
Thrombophilia off-label use 234467004 DOID:2452
Heart Failure with Paroxysmal Atrial Fibrillation off-label use
Nutritional disorder contraindication 2492009 DOID:374
Pericarditis contraindication 3238004 DOID:1787
Necrosis contraindication 6574001
Alcoholism contraindication 7200002
Obstruction of bile duct contraindication 30144000
Vasculitis contraindication 31996006 DOID:865
Hyperthyroidism contraindication 34486009 DOID:7998
Gangrene contraindication 36024000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Secondary uterine inertia contraindication 43715006
Tropical sprue contraindication 47384003 DOID:10607
Nephrotic syndrome contraindication 52254009 DOID:1184
Vitamin K deficiency contraindication 52675005 DOID:11249
Threatened abortion contraindication 54048003 DOID:9667
Hyperlipidemia contraindication 55822004 DOID:1168
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Fatty stool contraindication 66187002
Psychotic disorder contraindication 69322001
Heparin-induced thrombocytopenia contraindication 73397007
Gastrointestinal hemorrhage contraindication 74474003
Protein C deficiency disease contraindication 76407009 DOID:3756
Respiratory tract hemorrhage contraindication 95431003
Disorder of connective tissue contraindication 105969002 DOID:65
Polycythemia vera contraindication 109992005
Procedure on central nervous system contraindication 118679007
Intracranial aneurysm contraindication 128609009 DOID:10941
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Eclampsia in pregnancy contraindication 198992004
Local anesthetic intrathecal block contraindication 231249005
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Lumbar puncture contraindication 277762005
Pregnancy, function contraindication 289908002
Bacterial endocarditis contraindication 301183007
Dissection of aorta contraindication 308546005
Primary malignant neoplasm contraindication 372087000
Surgical procedure on eye proper contraindication 373353005
Pericardial effusion contraindication 373945007 DOID:118
Fever contraindication 386661006
Surgical procedure contraindication 387713003
Severe diarrhea contraindication 409587002
Traumatic injury contraindication 417746004
Genitourinary tract hemorrhage contraindication 417941003
Poor metabolizer due to cytochrome p450 CYP2C9 variant contraindication 424451001
Hypertensive urgency contraindication 443482000
Internal Hemorrhage contraindication
Indwelling Vascular Catheter contraindication
Cholesterol Embolism contraindication
Severe Diabetes Mellitus contraindication
Bleeding Risk Associated with Vitamin-K-Epoxide Reductase (Warfarin-Sensitive) Gene contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.96 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin K epoxide reductase complex subunit 1 Enzyme INHIBITOR IC50 7 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 3.98 WOMBAT-PK
Cytochrome P450 2C9 Enzyme Ki 4.87 WOMBAT-PK
Proprotein convertase subtilisin/kexin type 7 Enzyme IC50 4.61 CHEMBL
Vitamin K epoxide reductase complex subunit 1-like protein 1 Enzyme Ki 4.28 SCIENTIFIC LITERATURE

External reference:

IDSource
4019972 VUID
N0000148057 NUI
D00564 KEGG_DRUG
129-06-6 SECONDARY_CAS_RN
4018548 VANDF
4019972 VANDF
C0043031 UMLSCUI
CHEBI:10033 CHEBI
CHEMBL1464 ChEMBL_ID
DB00682 DRUGBANK_ID
CHEMBL1200879 ChEMBL_ID
D014859 MESH_DESCRIPTOR_UI
54678486 PUBCHEM_CID
6853 IUPHAR_LIGAND_ID
341 INN_ID
2610-86-8 SECONDARY_CAS_RN
5Q7ZVV76EI UNII
11289 RXNORM
1258 MMSL
5693 MMSL
d00022 MMSL
002084 NDDF
002085 NDDF
004065 NDDF
372756006 SNOMEDCT_US
41509001 SNOMEDCT_US
48603004 SNOMEDCT_US
63167009 SNOMEDCT_US
CHEMBL1200772 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1712 TABLET 1 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1712 TABLET 1 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1713 TABLET 2 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1713 TABLET 2 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1714 TABLET 2.50 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1714 TABLET 2.50 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1715 TABLET 3 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1715 TABLET 3 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1716 TABLET 4 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1716 TABLET 4 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1718 TABLET 6 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1718 TABLET 6 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1720 TABLET 10 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1720 TABLET 10 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1721 TABLET 5 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1721 TABLET 5 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1723 TABLET 7.50 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1723 TABLET 7.50 mg ORAL ANDA 29 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1211 TABLET 1 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1211 TABLET 1 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1212 TABLET 2 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1212 TABLET 2 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1213 TABLET 2.50 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1213 TABLET 2.50 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1214 TABLET 3 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1214 TABLET 3 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1215 TABLET 4 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1215 TABLET 4 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1216 TABLET 5 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1216 TABLET 5 mg ORAL ANDA 30 sections