warfarin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2847	81-81-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: warfarin warfarin sodium warfarin potassium	An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide. Molecular weight: 308.33 Formula: C19H16O4 CLOGP: 2.90 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 63.60 ALOGS: -3.82 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

warfarin
warfarin sodium
warfarin potassium

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

Molecular weight: 308.33
Formula: C19H16O4
CLOGP: 2.90
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 63.60
ALOGS: -3.82
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
7.50	mg	O
7.50	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.02 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.54 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	93 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.13 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.06 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	29 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 8, 1954	FDA	BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
International normalised ratio increased	8172.47	10.08	3715	183397	39437	50378575
Drug interaction	1143.56	10.08	2373	184739	197248	50220764
Calciphylaxis	938.30	10.08	357	186755	2281	50415731
Drug ineffective	896.92	10.08	1032	186080	818301	49599711
International normalised ratio abnormal	845.84	10.08	338	186774	2505	50415507
International normalised ratio decreased	842.63	10.08	376	186736	3772	50414240
Pulmonary arterial hypertension	837.21	10.08	654	186458	19665	50398347
Dyspnoea	602.11	10.08	3763	183349	543845	49874167
Fluid retention	582.23	10.08	822	186290	49827	50368185
Gastrointestinal haemorrhage	524.96	10.08	959	186153	72362	50345650
International normalised ratio fluctuation	514.67	10.08	220	186892	1970	50416042
Anticoagulation drug level above therapeutic	513.91	10.08	185	186927	987	50417025
Haematoma	478.13	10.08	577	186535	29933	50388079
Haemorrhage	448.80	10.08	750	186362	52691	50365321
Synovitis	414.16	10.08	9	187103	123856	50294156
Cardiac failure congestive	411.97	10.08	942	186170	83440	50334572
Epistaxis	398.99	10.08	789	186323	63165	50354847
Pulmonary hypertension	396.80	10.08	551	186561	32866	50385146
Atrial fibrillation	390.83	10.08	1036	186076	100709	50317303
Pain in jaw	381.24	10.08	582	186530	37846	50380166
Subdural haematoma	378.58	10.08	342	186770	12605	50405407
Labelled drug-drug interaction medication error	365.36	10.08	306	186806	10171	50407841
Right ventricular failure	353.35	10.08	361	186751	15532	50402480
Contraindicated product administered	349.65	10.08	64	187048	148894	50269118
Hypervolaemia	341.71	10.08	446	186666	25053	50392959
Drug intolerance	341.30	10.08	193	186919	218911	50199101
Treatment failure	336.58	10.08	53	187059	137584	50280428
Catheter site erythema	334.91	10.08	199	186913	3763	50414249
Infusion related reaction	327.96	10.08	109	187003	169448	50248564
Cerebral haemorrhage	327.08	10.08	450	186662	26602	50391410
Rheumatoid arthritis	326.26	10.08	171	186941	202379	50215633
Dyspnoea exertional	314.61	10.08	628	186484	50605	50367407
Glossodynia	307.67	10.08	34	187078	115535	50302477
Melaena	304.13	10.08	433	186679	26431	50391581
Prothrombin time prolonged	303.78	10.08	256	186856	8582	50409430
Alopecia	298.30	10.08	280	186832	244767	50173245
Joint swelling	290.75	10.08	287	186825	244999	50173013
Cardiac failure	285.54	10.08	768	186344	75272	50342740
Device related infection	281.44	10.08	365	186747	20370	50397642
Off label use	277.60	10.08	868	186244	473558	49944454
Haemoglobin decreased	264.44	10.08	1050	186062	126166	50291846
Hand deformity	262.89	10.08	31	187081	100168	50317844
Catheter site pain	262.03	10.08	167	186945	3595	50414417
Therapeutic product effect decreased	256.91	10.08	91	187021	135959	50282053
Coagulopathy	254.75	10.08	323	186789	17621	50400391
Drug hypersensitivity	254.73	10.08	333	186779	250677	50167335
Catheter management	240.50	10.08	141	186971	2598	50415414
Systemic lupus erythematosus	239.54	10.08	110	187002	140512	50277500
Abdominal wall haematoma	239.35	10.08	140	186972	2568	50415444
Arthropathy	238.80	10.08	144	186968	157762	50260250
Arthralgia	234.29	10.08	835	186277	437867	49980145
Transfusion	230.34	10.08	261	186851	12644	50405368
Anaemia	216.21	10.08	1635	185477	250821	50167191
Rectal haemorrhage	214.69	10.08	454	186658	38104	50379908
Oedema peripheral	213.38	10.08	1149	185963	156812	50261200
Anticoagulation drug level below therapeutic	208.53	10.08	82	187030	579	50417433
Pericarditis	207.26	10.08	24	187088	78665	50339347
Haemorrhage intracranial	205.29	10.08	241	186871	12133	50405879
Thrombosis	196.69	10.08	551	186561	55282	50362730
Syncope	193.31	10.08	824	186288	102178	50315834
Catheter site discharge	193.15	10.08	107	187005	1761	50416251
Musculoskeletal stiffness	190.28	10.08	120	186992	128361	50289651
Hypersensitivity	190.27	10.08	314	186798	214847	50203165
Haemoptysis	187.28	10.08	338	186774	25235	50392777
Catheter site pruritus	186.98	10.08	107	187005	1880	50416132
Pain	183.24	10.08	1322	185790	577581	49840431
Rash	181.99	10.08	916	186196	436555	49981457
Haematuria	179.31	10.08	332	186780	25281	50392731
Catheter site infection	176.55	10.08	138	186974	4148	50413864
Hypotension	174.22	10.08	1475	185637	233994	50184018
Hepatic enzyme increased	174.12	10.08	151	186961	137229	50280783
Oedema	170.35	10.08	609	186503	69572	50348440
Muscle haemorrhage	166.53	10.08	115	186997	2843	50415169
Central venous catheterisation	164.59	10.08	101	187011	2029	50415983
Infusion site pain	156.21	10.08	210	186902	12136	50405876
Discomfort	155.34	10.08	105	187007	108275	50309737
Wound	153.64	10.08	101	187011	105693	50312319
Hospitalisation	152.66	10.08	575	186537	67362	50350650
Catheter site haemorrhage	150.61	10.08	106	187006	2704	50415308
Device leakage	150.07	10.08	144	186968	5734	50412278
Death	146.38	10.08	1841	185271	323538	50094474
Heparin-induced thrombocytopenia	142.78	10.08	118	186994	3847	50414165
Duodenal ulcer perforation	142.70	10.08	6	187106	45605	50372407
Helicobacter infection	139.11	10.08	12	187100	49690	50368322
Stomatitis	137.61	10.08	104	187008	101240	50316772
Device alarm issue	136.68	10.08	77	187035	1311	50416701
Ecchymosis	136.40	10.08	178	186934	9991	50408021
Exposure during pregnancy	132.66	10.08	151	186961	120864	50297148
Catheter site swelling	130.84	10.08	74	187038	1270	50416742
Febrile neutropenia	130.35	10.08	102	187010	97565	50320447
Coagulation time prolonged	126.54	10.08	69	187043	1099	50416913
Catheter placement	124.21	10.08	83	187029	1941	50416071
Prothrombin time abnormal	124.01	10.08	49	187063	351	50417661
Product use issue	123.97	10.08	227	186885	149248	50268764
Therapeutic product effect incomplete	122.86	10.08	95	187017	91420	50326592
Oxygen saturation decreased	120.79	10.08	564	186548	72684	50345328
Folliculitis	119.98	10.08	6	187106	39219	50378793
Subdural haemorrhage	118.65	10.08	91	187021	2658	50415354
Retroperitoneal haematoma	117.40	10.08	89	187023	2554	50415458
Infusion site infection	115.74	10.08	72	187040	1483	50416529
Nasal congestion	111.79	10.08	429	186683	50691	50367321
Psoriatic arthropathy	110.71	10.08	20	187092	47012	50371000
Abdominal discomfort	109.11	10.08	463	186649	231178	50186834
Maternal exposure during pregnancy	108.08	10.08	272	186840	159506	50258506
Fall	106.79	10.08	1785	185327	333147	50084865
Irritable bowel syndrome	106.73	10.08	29	187083	51412	50366600
Muscle injury	106.53	10.08	8	187104	37103	50380909
Flushing	106.11	10.08	510	186602	66505	50351507
Deep vein thrombosis	104.84	10.08	542	186570	72762	50345250
Chest pain	104.39	10.08	1056	186056	175826	50242186
Thrombosis in device	99.59	10.08	82	187030	2659	50415353
Catheter site inflammation	98.57	10.08	49	187063	638	50417374
Injection site pain	98.05	10.08	162	186950	110862	50307150
Skin necrosis	97.19	10.08	157	186955	10710	50407302
Sleep disorder due to general medical condition, insomnia type	95.58	10.08	5	187107	31442	50386570
Upper gastrointestinal haemorrhage	95.31	10.08	194	186918	15841	50402171
Cardiac pacemaker insertion	94.22	10.08	90	187022	3563	50414449
Product use in unapproved indication	94.14	10.08	178	186934	115641	50302371
Palpitations	93.35	10.08	634	186478	93872	50324140
Pulmonary embolism	92.67	10.08	669	186443	101035	50316977
Sinusitis	92.45	10.08	322	186790	170236	50247776
Retroperitoneal haemorrhage	91.90	10.08	76	187036	2480	50415532
Bradycardia	90.49	10.08	474	186638	63952	50354060
Infusion site erythema	89.08	10.08	134	186978	8593	50409419
Neutropenia	88.77	10.08	267	186845	147698	50270314
Pneumonia aspiration	87.45	10.08	283	186829	30721	50387291
Depression	86.53	10.08	317	186795	165106	50252906
Presyncope	85.36	10.08	239	186873	23959	50394053
Lung transplant	85.28	10.08	76	187036	2749	50415263
Injection site reaction	83.79	10.08	40	187072	49992	50368020
Psoriasis	83.60	10.08	79	187033	68921	50349091
Haemorrhage subcutaneous	82.21	10.08	73	187039	2628	50415384
Cardiac valve replacement complication	81.82	10.08	28	187084	125	50417887
Pneumonia	80.59	10.08	1898	185214	376503	50041509
Vascular device infection	80.50	10.08	90	187022	4294	50413718
Intentional overdose	79.99	10.08	68	187044	62436	50355576
Drug abuse	79.20	10.08	63	187049	59783	50358229
Malignant neoplasm progression	79.07	10.08	81	187031	68043	50349969
Shock haemorrhagic	77.98	10.08	123	186989	8221	50409791
Blood cholesterol increased	77.08	10.08	55	187057	55160	50362852
Dizziness	77.03	10.08	1748	185364	344621	50073391
Pulmonary oedema	76.42	10.08	371	186741	48567	50369445
Atrial flutter	76.19	10.08	125	186987	8638	50409374
Device occlusion	75.50	10.08	102	187010	5921	50412091
Cardiac disorder	75.33	10.08	337	186775	42642	50375370
Faeces discoloured	75.26	10.08	177	186935	15947	50402065
Lower respiratory tract infection	75.02	10.08	149	186963	95052	50322960
Pulmonary arterial pressure increased	74.31	10.08	76	187036	3272	50414740
Ill-defined disorder	74.27	10.08	56	187056	54598	50363414
Infection	73.44	10.08	359	186753	172595	50245417
Coagulation test abnormal	73.42	10.08	40	187072	636	50417376
Injection site erythema	73.23	10.08	102	187010	74834	50343178
Loss of personal independence in daily activities	72.90	10.08	91	187021	69959	50348053
Intra-abdominal haematoma	72.65	10.08	54	187058	1503	50416509
Catheterisation cardiac	72.58	10.08	82	187030	3958	50414054
Suicidal ideation	72.42	10.08	59	187053	55326	50362686
Completed suicide	72.12	10.08	248	186864	131641	50286371
Hypertension	72.03	10.08	471	186641	210732	50207280
Catheter site rash	71.96	10.08	41	187071	714	50417298
Urticaria	71.27	10.08	243	186869	129318	50288694
Lower gastrointestinal haemorrhage	70.75	10.08	106	187006	6773	50411239
Pulmonary thrombosis	70.25	10.08	111	187001	7430	50410582
Blood pressure decreased	70.20	10.08	399	186713	55510	50362502
Complication associated with device	69.63	10.08	162	186950	14493	50403519
Impaired healing	69.19	10.08	94	187018	69692	50348320
Haematemesis	68.43	10.08	242	186870	27483	50390529
Blister	67.03	10.08	134	186978	85284	50332728
Swelling	66.97	10.08	451	186661	200421	50217591
Multiple sclerosis relapse	66.54	10.08	38	187074	42926	50375086
Haemarthrosis	66.34	10.08	67	187045	2841	50415171
Pruritus	65.59	10.08	701	186411	282867	50135145
Blood loss anaemia	65.30	10.08	112	187000	8027	50409985
Device related sepsis	64.94	10.08	72	187040	3403	50414609
Haemorrhagic stroke	64.72	10.08	88	187024	5140	50412872
Cerebrovascular accident	64.57	10.08	583	186529	94097	50323915
Leukopenia	63.92	10.08	94	187018	67434	50350578
Hypocoagulable state	63.82	10.08	41	187071	895	50417117
Dialysis	63.13	10.08	120	186992	9318	50408694
Device expulsion	62.18	10.08	15	187097	28807	50389205
Internal haemorrhage	61.87	10.08	79	187033	4338	50413674
Paraesthesia	61.82	10.08	232	186880	120011	50298001
Therapy change	60.26	10.08	85	187027	5140	50412872
Sleep disorder	60.04	10.08	74	187038	57209	50360803
Anaphylactic reaction	59.69	10.08	67	187045	53988	50364024
Spinal epidural haematoma	59.35	10.08	40	187072	949	50417063
Activated partial thromboplastin time prolonged	59.31	10.08	94	187018	6308	50411704
Cardioactive drug level increased	59.15	10.08	53	187059	1931	50416081
General physical health deterioration	57.40	10.08	301	186811	142133	50275879
Osteoarthritis	57.00	10.08	104	187008	68502	50349510
Subarachnoid haemorrhage	56.64	10.08	124	186988	10652	50407360
Cardiac operation	55.87	10.08	60	187052	2735	50415277
Gastrointestinal disorder	55.51	10.08	172	186940	94284	50323728
Dermatitis contact	55.46	10.08	108	187004	8538	50409474
Injection site pruritus	55.43	10.08	41	187071	40370	50377642
Spontaneous haematoma	55.01	10.08	35	187077	751	50417261
Asthenia	54.89	10.08	1556	185556	317486	50100526
Subcutaneous haematoma	54.37	10.08	45	187067	1470	50416542
Device infusion issue	54.12	10.08	43	187069	1324	50416688
Intra-abdominal haemorrhage	54.07	10.08	53	187059	2167	50415845
Cardiac ablation	54.02	10.08	42	187070	1252	50416760
Pulmonary endarterectomy	53.88	10.08	20	187092	118	50417894
Mucosal inflammation	53.43	10.08	42	187070	40100	50377912
Fibromyalgia	52.73	10.08	53	187059	44925	50373087
Type 2 diabetes mellitus	52.39	10.08	31	187081	34344	50383668
Seizure	51.56	10.08	242	186870	117632	50300380
Therapeutic response decreased	50.57	10.08	60	187052	47171	50370841
Food interaction	50.41	10.08	31	187081	625	50417387
Injection site swelling	50.39	10.08	48	187064	41725	50376287
Acute kidney injury	50.30	10.08	1150	185962	226908	50191104
Transplant evaluation	49.99	10.08	37	187075	1023	50416989
Acute respiratory failure	49.92	10.08	225	186887	28557	50389455
Malaise	49.54	10.08	1606	185506	333926	50084086
Red blood cell sedimentation rate increased	48.52	10.08	24	187088	29392	50388620
Intraventricular haemorrhage	48.09	10.08	46	187066	1824	50416188
Fatigue	47.90	10.08	2135	184977	705466	49712546
Wrong technique in product usage process	47.14	10.08	83	187029	55427	50362585
Hypoaesthesia	46.87	10.08	277	186835	126980	50291032
Head injury	46.42	10.08	194	186918	23826	50394186
Haemoperitoneum	46.14	10.08	52	187060	2503	50415509
Catheter site irritation	45.93	10.08	27	187085	500	50417512
C-reactive protein increased	45.81	10.08	112	187000	66362	50351650
Pericardial haemorrhage	45.56	10.08	40	187072	1418	50416594
Choroidal haemorrhage	45.45	10.08	14	187098	41	50417971
Prosthetic cardiac valve thrombosis	45.14	10.08	12	187100	16	50417996
Torsade de pointes	44.83	10.08	120	186992	11715	50406297
Oxygen consumption increased	44.50	10.08	60	187052	3476	50414536
Infusion site discharge	44.12	10.08	28	187084	598	50417414
Mobility decreased	43.90	10.08	150	186962	79798	50338214
Pelvic haematoma	43.55	10.08	26	187086	496	50417516
Hypoxia	43.52	10.08	331	186781	50792	50367220
Vascular pseudoaneurysm	43.31	10.08	38	187074	1346	50416666
Post procedural haemorrhage	43.25	10.08	88	187024	7182	50410830
Medical device change	43.23	10.08	22	187090	302	50417710
Gout	43.14	10.08	116	186996	11354	50406658
Anxiety	42.66	10.08	435	186677	177171	50240841
Gastric haemorrhage	42.60	10.08	76	187036	5620	50412392
Catheter site related reaction	42.60	10.08	30	187082	766	50417246
Potentiating drug interaction	42.42	10.08	61	187051	3755	50414257
Inflammation	42.35	10.08	92	187020	56820	50361192
Hypercoagulation	42.03	10.08	43	187069	1852	50416160
Emergency care	41.34	10.08	30	187082	804	50417208
Anticoagulation drug level decreased	40.90	10.08	12	187100	28	50417984
Prothrombin time ratio increased	40.34	10.08	15	187097	89	50417923
Haematoma muscle	40.27	10.08	28	187084	700	50417312
Haematocrit decreased	40.26	10.08	244	186868	34732	50383280
Traumatic haematoma	40.19	10.08	36	187076	1311	50416701
Brain natriuretic peptide increased	39.93	10.08	65	187047	4462	50413550
Gingival bleeding	39.90	10.08	112	187000	11241	50406771
Cellulitis	39.46	10.08	418	186694	70380	50347632
Intentional self-injury	39.43	10.08	18	187094	23094	50394918
Cardioversion	39	10.08	33	187079	1112	50416900
Muscle spasticity	38.97	10.08	8	187104	17176	50400836
Anticoagulation drug level abnormal	38.86	10.08	9	187103	3	50418009
Dyspnoea at rest	38.66	10.08	57	187055	3590	50414422
Catheter site discolouration	38.62	10.08	15	187097	102	50417910
International normalised ratio	38.53	10.08	14	187098	77	50417935
Intentional product use issue	37.22	10.08	152	186960	76766	50341246
Occult blood positive	37.16	10.08	53	187059	3238	50414774
Congestive hepatopathy	37.15	10.08	46	187066	2448	50415564
Foetal warfarin syndrome	36.83	10.08	8	187104	0	50418012
Anticoagulant-related nephropathy	36.83	10.08	8	187104	0	50418012
Protein C decreased	36.82	10.08	11	187101	28	50417984
Cardiac failure chronic	36.78	10.08	55	187057	3508	50414504
Arthritis	36.77	10.08	180	186932	86541	50331471
Device breakage	36.36	10.08	97	187015	9450	50408562
Spinal cord haematoma	36.24	10.08	16	187096	156	50417856
Cerebellar haemorrhage	36.20	10.08	33	187079	1230	50416782
Intestinal haematoma	36.11	10.08	12	187100	48	50417964
Tongue haematoma	36.01	10.08	13	187099	70	50417942
Unevaluable event	35.76	10.08	292	186820	45774	50372238
Catheter removal	35.53	10.08	20	187092	340	50417672
Anticoagulation drug level increased	35.46	10.08	16	187096	165	50417847
Embolism	35.29	10.08	79	187033	6889	50411123
Drug monitoring procedure not performed	35.20	10.08	22	187090	457	50417555
Suicide attempt	34.98	10.08	88	187024	51644	50366368
Heart valve replacement	34.95	10.08	22	187090	463	50417549
Dizziness postural	34.93	10.08	73	187039	6072	50411940
Infusion site haemorrhage	34.84	10.08	49	187063	2955	50415057
Asthma	34.20	10.08	192	186920	89145	50328867
Device connection issue	34.19	10.08	23	187089	544	50417468
Haematoma evacuation	33.82	10.08	15	187097	148	50417864
Brain herniation	33.75	10.08	49	187063	3043	50414969
Spinal subdural haematoma	33.58	10.08	14	187098	117	50417895
Catheter culture positive	33.58	10.08	14	187098	117	50417895
Arrhythmia	33.11	10.08	223	186889	32909	50385103
Cognitive disorder	33.10	10.08	71	187041	44052	50373960
Gangrene	33.05	10.08	61	187051	4631	50413381
Oxygen therapy	32.93	10.08	37	187075	1775	50416237
Pleural effusion	32.74	10.08	452	186660	81002	50337010
Foot deformity	32.71	10.08	15	187097	19195	50398817
Ovarian haemorrhage	32.61	10.08	18	187094	294	50417718
Oral herpes	32.56	10.08	18	187094	20707	50397305
Skin weeping	32.49	10.08	20	187092	404	50417608
Pericardial effusion	32.36	10.08	183	186929	25406	50392606
Pregnancy	32.28	10.08	37	187075	29540	50388472
Blood viscosity decreased	32.16	10.08	11	187101	49	50417963
Mineral supplementation	32.07	10.08	24	187088	675	50417337
Infusion site cellulitis	32.00	10.08	15	187097	170	50417842
Hyperkalaemia	31.69	10.08	294	186818	47795	50370217
Vascular pseudoaneurysm ruptured	31.47	10.08	11	187101	53	50417959
Pancytopenia	31.41	10.08	182	186930	83848	50334164
Prothrombin consumption time prolonged	31.13	10.08	10	187102	35	50417977
Pulmonary haemorrhage	31.10	10.08	72	187040	6420	50411592
Cough	30.83	10.08	1136	185976	240128	50177884
Cardiac failure acute	30.59	10.08	83	187029	8167	50409845
Eye haemorrhage	30.48	10.08	77	187035	7258	50410754
Aortic valve replacement	30.34	10.08	23	187089	660	50417352
Acute myeloid leukaemia	30.33	10.08	9	187103	15065	50402947
Serotonin syndrome	30.27	10.08	28	187084	24685	50393327
Central venous catheter removal	30.21	10.08	18	187094	342	50417670
Headache	30.15	10.08	2217	184895	504318	49913694
Renal failure	30.15	10.08	558	186554	106075	50311937
Pyrexia	30.11	10.08	1126	185986	379077	50038935
Foetal exposure during pregnancy	30.10	10.08	34	187078	27325	50390687
Psychotic disorder	30.08	10.08	22	187090	21790	50396222
Adrenal haemorrhage	29.97	10.08	19	187093	405	50417607
Ventricular tachycardia	29.96	10.08	127	186985	15694	50402318
Catheter site warmth	29.73	10.08	15	187097	202	50417810
Generalised tonic-clonic seizure	29.71	10.08	32	187080	26278	50391734
Atrial tachycardia	29.66	10.08	38	187074	2094	50415918
Accidental exposure to product	29.59	10.08	25	187087	23032	50394980
Orthopnoea	29.37	10.08	65	187047	5624	50412388
Renal vascular thrombosis	29.34	10.08	10	187102	44	50417968
Ascites	29.30	10.08	230	186882	35631	50382381
Myelosuppression	29.22	10.08	7	187105	13510	50404502
Knee arthroplasty	29.18	10.08	55	187057	35791	50382221
Basal cell carcinoma	29.16	10.08	26	187086	23330	50394682
Protein S decreased	29.06	10.08	9	187103	27	50417985
Contusion	28.97	10.08	579	186533	111604	50306408
Haemothorax	28.87	10.08	36	187076	1930	50416082
Rheumatoid nodule	28.73	10.08	6	187106	12729	50405283
Neutrophil count decreased	28.33	10.08	82	187030	45944	50372068
Atrial thrombosis	28.29	10.08	31	187081	1446	50416566
Toxicity to various agents	28.26	10.08	585	186527	211914	50206098
COVID-19	28.09	10.08	84	187028	46578	50371434
Angioedema	27.95	10.08	61	187051	37615	50380397
Catheter site vesicles	27.66	10.08	16	187096	287	50417725
Infusion site irritation	27.66	10.08	21	187091	604	50417408
Cardiac valve disease	27.66	10.08	50	187062	3736	50414276
Heart rate increased	27.61	10.08	420	186692	76830	50341182
Hypovolaemic shock	27.61	10.08	60	187052	5128	50412884
Antiphospholipid syndrome	27.61	10.08	31	187081	1486	50416526
Mediastinal haematoma	27.58	10.08	11	187101	81	50417931
Calcium deficiency	27.58	10.08	25	187087	925	50417087
Heart rate irregular	27.55	10.08	143	186969	19217	50398795
Respiratory failure	27.49	10.08	482	186630	90699	50327313
Infusion site swelling	27.42	10.08	73	187039	7103	50410909
Infusion site warmth	27.30	10.08	30	187082	1404	50416608
Drug dependence	27.16	10.08	20	187092	19739	50398273
Ischaemic stroke	27.15	10.08	124	186988	15824	50402188
Disturbance in attention	27.05	10.08	46	187066	31140	50386872
Drug level changed	26.94	10.08	13	187099	158	50417854
Osteoporosis	26.87	10.08	81	187031	44798	50373214
Cerebral haematoma	26.84	10.08	45	187067	3166	50414846
Sedation	26.69	10.08	45	187067	30565	50387447
Cerebral mass effect	26.59	10.08	23	187089	799	50417213
Extradural haematoma	26.47	10.08	31	187081	1556	50416456
Blood potassium decreased	26.46	10.08	230	186882	36715	50381297
Stress	26.21	10.08	106	187006	53687	50364325
Anovulatory cycle	26.16	10.08	12	187100	129	50417883
Ear pain	26.15	10.08	40	187072	28243	50389769
Bursitis	26.04	10.08	26	187086	22109	50395903
Blood viscosity increased	25.90	10.08	14	187098	219	50417793
Sciatic nerve palsy	25.83	10.08	8	187104	24	50417988
Intestinal haemorrhage	25.83	10.08	44	187068	3136	50414876
Intracardiac thrombus	25.82	10.08	36	187076	2153	50415859
Blood pressure increased	25.76	10.08	342	186770	132790	50285222
Product complaint	25.69	10.08	97	187015	11369	50406643
Palmar-plantar erythrodysaesthesia syndrome	25.54	10.08	22	187090	20076	50397936
Breast necrosis	25.45	10.08	12	187100	138	50417874
Injection site discharge	25.42	10.08	17	187095	398	50417614
Hip arthroplasty	25.38	10.08	46	187066	30383	50387629
Abortion spontaneous	25.29	10.08	75	187037	41697	50376315
Bradyarrhythmia	25.22	10.08	33	187079	1857	50416155
No adverse event	25.21	10.08	54	187058	33524	50384488
Vitamin K deficiency	25.13	10.08	17	187095	406	50417606
Infusion site abscess	25.07	10.08	13	187099	186	50417826
Breast haematoma	25.01	10.08	13	187099	187	50417825
Thyroid haemorrhage	24.70	10.08	9	187103	50	50417962
Disease complication	24.61	10.08	40	187072	2742	50415270
Mitral valve disease	24.41	10.08	34	187078	2032	50415980
Tuberculosis	24.36	10.08	4	187108	10079	50407933
Dilatation ventricular	24.16	10.08	36	187076	2289	50415723
Abdominal distension	24.02	10.08	391	186721	72512	50345500
Endarterectomy	24.02	10.08	12	187100	158	50417854
Hepatotoxicity	23.76	10.08	40	187072	27186	50390826
Cytomegalovirus infection	23.64	10.08	19	187093	17943	50400069
Hypoprothrombinaemia	23.64	10.08	14	187098	263	50417749
Myxoedema coma	23.62	10.08	16	187096	383	50417629
Neuroleptic malignant syndrome	23.60	10.08	6	187106	11124	50406888
Atrial septal defect repair	23.57	10.08	13	187099	212	50417800
Right ventricular dysfunction	23.48	10.08	29	187083	1539	50416473
Injury	23.47	10.08	97	187015	48828	50369184
Haematochezia	23.41	10.08	238	186874	39644	50378368
Insomnia	23.36	10.08	481	186631	174384	50243628
Petechiae	23.35	10.08	100	187012	12412	50405600
Sepsis	23.25	10.08	650	186462	132275	50285737
Immunodeficiency	23.12	10.08	13	187099	14815	50403197
Infusion site oedema	23.08	10.08	18	187094	539	50417473
Haemorrhagic ovarian cyst	23.02	10.08	19	187093	618	50417394
Blood viscosity abnormal	23.02	10.08	5	187107	0	50418012
Colitis	22.74	10.08	70	187042	38459	50379553
Gastrooesophageal reflux disease	22.67	10.08	403	186709	76025	50341987
Neoplasm progression	22.64	10.08	46	187066	29111	50388901
Haemorrhagic diathesis	22.56	10.08	47	187065	3901	50414111
Herpes zoster	22.53	10.08	161	186951	70625	50347387
Compartment syndrome	22.50	10.08	32	187080	1950	50416062
Protein S deficiency	22.13	10.08	7	187105	23	50417989
Coagulation time shortened	22.07	10.08	11	187101	144	50417868
Prothrombin level abnormal	21.93	10.08	9	187103	72	50417940
Cytokine release syndrome	21.83	10.08	3	187109	8631	50409381
Mouth haemorrhage	21.65	10.08	61	187051	6135	50411877
Scleroderma	21.64	10.08	52	187060	4749	50413263
Pulmonary arterial pressure abnormal	21.60	10.08	16	187096	443	50417569
Tendonitis	21.58	10.08	18	187094	16687	50401325
Adverse drug reaction	21.50	10.08	118	186994	55104	50362908
Vaginal haemorrhage	21.47	10.08	160	186952	24391	50393621
Gastric antral vascular ectasia	21.30	10.08	17	187095	527	50417485
Atrioventricular block complete	21.16	10.08	67	187045	7188	50410824
Joint stiffness	20.92	10.08	51	187061	30257	50387755
Drug withdrawal syndrome	20.84	10.08	38	187074	25043	50392969
Mitral valve repair	20.75	10.08	11	187101	165	50417847
Cardiogenic shock	20.68	10.08	113	186999	15486	50402526
Medical device site thrombosis	20.68	10.08	5	187107	3	50418009
Catheter site nodule	20.65	10.08	8	187104	54	50417958
Drug resistance	20.45	10.08	24	187088	18965	50399047
Injection site warmth	20.44	10.08	13	187099	13853	50404159
Catheter site dermatitis	20.40	10.08	8	187104	56	50417956
Lupus-like syndrome	20.35	10.08	5	187107	9486	50408526
Infusion site pruritus	20.35	10.08	45	187067	3892	50414120
Drug eruption	20.31	10.08	35	187077	23571	50394441
Dizziness exertional	20.27	10.08	14	187098	346	50417666
Blood culture negative	20.13	10.08	10	187102	130	50417882
Injection site urticaria	20.10	10.08	10	187102	12207	50405805
Spinal subarachnoid haemorrhage	20.10	10.08	5	187107	4	50418008
Heart valve operation	20.06	10.08	10	187102	131	50417881
Ovarian rupture	19.98	10.08	7	187105	34	50417978
Abdominal wall haemorrhage	19.80	10.08	10	187102	135	50417877
Device difficult to use	19.71	10.08	6	187106	9880	50408132
Aortic stenosis	19.53	10.08	46	187066	4148	50413864
Application site pruritus	19.47	10.08	43	187069	3716	50414296
Hip fracture	19.39	10.08	163	186949	25768	50392244
Liver injury	19.38	10.08	39	187073	24767	50393245
Breast cancer	19.37	10.08	87	187025	42803	50375209
Walking distance test abnormal	19.35	10.08	16	187096	522	50417490
Lethargy	19.33	10.08	273	186839	49159	50368853
Drug tolerance decreased	19.31	10.08	5	187107	9155	50408857
Dystonia	19.26	10.08	10	187102	11916	50406096
Lymphocyte count decreased	19.18	10.08	43	187069	26264	50391748
Blood pressure fluctuation	19.13	10.08	68	187044	35755	50382257
Oral mucosa haematoma	19.10	10.08	5	187107	6	50418006
Cholecystitis chronic	19.04	10.08	6	187106	9663	50408349
Injection site rash	19.03	10.08	19	187093	16158	50401854
Dehydration	19.01	10.08	716	186396	151733	50266279
Cardiac flutter	18.95	10.08	40	187072	3350	50414662
Multiple sclerosis	18.93	10.08	29	187083	20464	50397548
Gastrointestinal arteriovenous malformation	18.89	10.08	16	187096	540	50417472
Cardiomegaly	18.83	10.08	112	187000	15833	50402179
Acne	18.81	10.08	27	187085	19568	50398444
Coagulation factor decreased	18.76	10.08	7	187105	42	50417970
Gait disturbance	18.75	10.08	417	186695	149588	50268424
Pneumocystis jirovecii pneumonia	18.69	10.08	16	187096	14647	50403365
Nephrosclerosis	18.69	10.08	20	187092	908	50417104
Cardioactive drug level decreased	18.68	10.08	8	187104	72	50417940
Product storage error	18.66	10.08	11	187101	12213	50405799
Device dislocation	18.61	10.08	140	186972	21406	50396606
Catheter site oedema	18.49	10.08	7	187105	44	50417968
Skin exfoliation	18.49	10.08	63	187049	33549	50384463
Prescribed underdose	18.46	10.08	19	187093	15930	50402082
Dry eye	18.45	10.08	59	187053	32036	50385976
Valvuloplasty cardiac	18.42	10.08	4	187108	0	50418012
Tracheal calcification	18.42	10.08	4	187108	0	50418012
Femoral nerve palsy	18.42	10.08	4	187108	0	50418012
Polyneuropathy	18.40	10.08	11	187101	12120	50405892
Diarrhoea	18.38	10.08	2463	184649	586013	49831999
Aortic dissection	18.37	10.08	26	187086	1577	50416435
Conjunctival haemorrhage	18.29	10.08	37	187075	3007	50415005
Balloon atrial septostomy	18.12	10.08	8	187104	78	50417934
Renal disorder	18.04	10.08	168	186944	27337	50390675
Sinus node dysfunction	18.00	10.08	43	187069	3912	50414100
Gestational diabetes	17.95	10.08	3	187109	7462	50410550
Hepatorenal failure	17.76	10.08	16	187096	587	50417425
Haemophagocytic lymphohistiocytosis	17.65	10.08	5	187107	8628	50409384
Retching	17.61	10.08	94	187018	12768	50405244
Concomitant disease progression	17.55	10.08	29	187083	2016	50415996
Mood swings	17.36	10.08	20	187092	15934	50402078
Nocturnal dyspnoea	17.20	10.08	20	187092	996	50417016
Metastases to liver	17.12	10.08	30	187082	20074	50397938
White blood cell count decreased	17.12	10.08	316	186796	116406	50301606
Abdominal cavity drainage	17.09	10.08	13	187099	375	50417637
Body temperature increased	17.06	10.08	59	187053	31282	50386730
Exercise tolerance decreased	17.05	10.08	48	187064	4826	50413186
Catheter site dryness	16.98	10.08	6	187106	30	50417982
Thoracic haemorrhage	16.98	10.08	6	187106	30	50417982
Injection site bruising	16.95	10.08	74	187038	36694	50381318
Aphthous ulcer	16.95	10.08	9	187103	10588	50407424
Drain placement	16.84	10.08	7	187105	58	50417954
Jugular vein distension	16.81	10.08	18	187094	818	50417194
Central nervous system lesion	16.80	10.08	7	187105	9482	50408530
Large intestinal polypectomy	16.74	10.08	10	187102	191	50417821
Mitral valve replacement	16.70	10.08	11	187101	251	50417761
Aggression	16.66	10.08	33	187079	21083	50396929
Subarachnoid haematoma	16.66	10.08	5	187107	13	50417999
Endocarditis	16.61	10.08	49	187063	5058	50412954
Blue toe syndrome	16.57	10.08	13	187099	393	50417619
Neurotoxicity	16.56	10.08	18	187094	14722	50403290
Metastases to lymph nodes	16.50	10.08	3	187109	7021	50410991
Night sweats	16.45	10.08	66	187046	33508	50384504
Pulmonary alveolar haemorrhage	16.45	10.08	42	187070	3985	50414027
Suture insertion	16.38	10.08	8	187104	100	50417912
Anaphylactic shock	16.34	10.08	31	187081	20124	50397888
Therapy interrupted	16.33	10.08	31	187081	20121	50397891
Stent placement	16.33	10.08	38	187074	3400	50414612
Thrombectomy	16.30	10.08	9	187103	147	50417865
Cardiac pacemaker replacement	16.30	10.08	12	187100	329	50417683
Dysentery	16.21	10.08	17	187095	754	50417258
Purple glove syndrome	16.20	10.08	10	187102	203	50417809
Device related thrombosis	16.18	10.08	22	187090	1285	50416727
Pancreatitis	16.08	10.08	92	187020	42522	50375490
Coeliac disease	16.05	10.08	6	187106	8679	50409333
Drug-induced liver injury	15.90	10.08	52	187060	28043	50389969
Spinal stenosis	15.84	10.08	16	187096	13534	50404478
Diabetic ketoacidosis	15.83	10.08	26	187086	17846	50400166
Hyphaema	15.83	10.08	9	187103	156	50417856
Mouth ulceration	15.77	10.08	52	187060	27972	50390040
Exostosis	15.75	10.08	12	187100	11641	50406371
Coma scale normal	15.66	10.08	4	187108	4	50418008
Oesophageal compression	15.66	10.08	4	187108	4	50418008
Hypercalcaemia	15.57	10.08	40	187072	23312	50394700
Myocarditis	15.53	10.08	5	187107	7942	50410070
Lymphopenia	15.52	10.08	21	187091	15600	50402412
Carpal tunnel syndrome	15.51	10.08	24	187088	16869	50401143
Panniculitis	15.50	10.08	6	187106	8497	50409515
Iron deficiency anaemia	15.46	10.08	111	187001	16723	50401289
Cardiac arrest	15.45	10.08	412	186700	83239	50334773
Exophthalmos	15.41	10.08	21	187091	1229	50416783
Arteriovenous malformation	15.31	10.08	21	187091	1237	50416775
Ovarian cyst ruptured	15.30	10.08	19	187093	1014	50416998
Accidental overdose	15.26	10.08	124	186988	19409	50398603
Progressive multifocal leukoencephalopathy	15.23	10.08	12	187100	11445	50406567
Withdrawal syndrome	15.20	10.08	26	187086	17564	50400448
Metastases to bone	15.19	10.08	27	187085	17968	50400044
Prothrombin level increased	15.18	10.08	10	187102	228	50417784
Cor pulmonale	15.18	10.08	26	187086	1861	50416151
Endotracheal intubation	15.17	10.08	28	187084	2126	50415886
Heart sounds abnormal	15.07	10.08	15	187097	625	50417387
Duodenal ulcer haemorrhage	15.06	10.08	28	187084	2138	50415874
Impaired work ability	14.95	10.08	17	187095	13623	50404389
Eschar	14.95	10.08	13	187099	455	50417557
Tri-iodothyronine increased	14.92	10.08	8	187104	123	50417889
Chronic respiratory failure	14.84	10.08	24	187088	1638	50416374
Traumatic intracranial haemorrhage	14.82	10.08	12	187100	380	50417632
Aplastic anaemia	14.78	10.08	5	187107	7698	50410314
Subdural haematoma evacuation	14.77	10.08	4	187108	6	50418006
Hepatocellular injury	14.70	10.08	48	187064	25899	50392113
Migraine	14.69	10.08	193	186919	75087	50342925
Cerebral infarction	14.69	10.08	133	186979	21471	50396541
Hydrocephalus	14.69	10.08	45	187067	4743	50413269
Hepatitis	14.69	10.08	63	187049	31390	50386622
Diastolic hypotension	14.66	10.08	7	187105	83	50417929
Hypercholesterolaemia	14.64	10.08	13	187099	11690	50406322
Neuropathy peripheral	14.48	10.08	261	186851	96496	50321516
Coagulation factor deficiency	14.40	10.08	4	187108	7	50418005
Uterine haemorrhage	14.35	10.08	36	187076	3379	50414633
Intervertebral disc protrusion	14.33	10.08	34	187078	20359	50397653
Obesity	14.31	10.08	25	187087	16750	50401262
Skin reaction	14.29	10.08	13	187099	11555	50406457
Encephalopathy	14.27	10.08	70	187042	33641	50384371
Vaginal haematoma	14.26	10.08	8	187104	135	50417877
Splenic haemorrhage	14.19	10.08	9	187103	192	50417820
Transaminases increased	14.08	10.08	54	187058	27770	50390242
Inappropriate schedule of product administration	14.08	10.08	184	186928	71647	50346365
Neutropenic sepsis	14.07	10.08	19	187093	14128	50403884
Premature labour	14.06	10.08	13	187099	11463	50406549
Intentional product misuse	14.05	10.08	108	187004	46626	50371386
Lacrimal haemorrhage	13.99	10.08	5	187107	26	50417986
Mitral valve stenosis	13.99	10.08	18	187094	996	50417016
Therapeutic product effect increased	13.96	10.08	18	187094	998	50417014
Osteopenia	13.95	10.08	26	187086	16992	50401020
Right ventricular systolic pressure increased	13.94	10.08	13	187099	499	50417513
Sinus tachycardia	13.92	10.08	37	187075	21317	50396695
Diet noncompliance	13.91	10.08	10	187102	264	50417748
Sickle cell anaemia	13.90	10.08	13	187099	501	50417511
Angioplasty	13.86	10.08	20	187092	1235	50416777
Blood potassium increased	13.85	10.08	106	187006	16292	50401720
Catheter site extravasation	13.84	10.08	10	187102	266	50417746
Thromboembolectomy	13.84	10.08	5	187107	27	50417985
Emergency care examination	13.82	10.08	6	187106	56	50417956
Prothrombin level decreased	13.81	10.08	13	187099	505	50417507
Acquired cardiac septal defect	13.81	10.08	3	187109	0	50418012
Adrenal cortex necrosis	13.81	10.08	3	187109	0	50418012
Iris haemorrhage	13.81	10.08	3	187109	0	50418012
Hepatic artery embolism	13.81	10.08	3	187109	0	50418012
Cardiac pacemaker adjustment	13.81	10.08	3	187109	0	50418012
Craniectomy	13.81	10.08	3	187109	0	50418012
Sleep disorder due to a general medical condition	13.78	10.08	5	187107	7366	50410646
Drug ineffective for unapproved indication	13.77	10.08	37	187075	21244	50396768
Rales	13.71	10.08	73	187039	9905	50408107
Device physical property issue	13.71	10.08	23	187089	1619	50416393
Brain operation	13.71	10.08	13	187099	510	50417502
Haemorrhagic cerebral infarction	13.70	10.08	14	187098	602	50417410
Haematotoxicity	13.70	10.08	6	187106	7889	50410123
Catheter site urticaria	13.69	10.08	5	187107	28	50417984
Venous haemorrhage	13.64	10.08	9	187103	206	50417806
Pharyngeal haematoma	13.54	10.08	5	187107	29	50417983
Implantable defibrillator insertion	13.54	10.08	11	187101	350	50417662
Illness	13.49	10.08	46	187066	24494	50393518
Periorbital haematoma	13.48	10.08	15	187097	712	50417300
Haematoma infection	13.48	10.08	13	187099	521	50417491
Prothrombin time shortened	13.45	10.08	23	187089	1644	50416368
Condition aggravated	13.36	10.08	932	186180	296126	50121886
Tremor	13.35	10.08	323	186789	114580	50303432
Restlessness	13.30	10.08	48	187064	25125	50392887
Thrombotic microangiopathy	13.29	10.08	8	187104	8783	50409229
Demyelination	13.27	10.08	3	187109	6023	50411989
Chordae tendinae rupture	13.26	10.08	5	187107	31	50417981
Abdominal compartment syndrome	13.23	10.08	13	187099	533	50417479
Loss of consciousness	13.21	10.08	491	186621	103862	50314150
Catheter site erosion	13.20	10.08	6	187106	63	50417949
Right ventricular enlargement	13.19	10.08	10	187102	287	50417725
Coma	13.18	10.08	289	186823	56590	50361422
Venous pressure jugular increased	13.17	10.08	13	187099	536	50417476
Rehabilitation therapy	13.17	10.08	20	187092	1293	50416719
Terminal state	13.10	10.08	26	187086	2084	50415928
Pyelonephritis	13.10	10.08	22	187090	14967	50403045
Haemorrhagic hepatic cyst	13	10.08	5	187107	33	50417979
Diverticulum intestinal haemorrhagic	12.95	10.08	19	187093	1191	50416821
Squamous cell carcinoma of the oral cavity	12.95	10.08	10	187102	295	50417717
Influenza like illness	12.86	10.08	143	186969	57316	50360696
Bronchopulmonary aspergillosis	12.82	10.08	6	187106	7586	50410426
Haemorrhagic ascites	12.81	10.08	7	187105	112	50417900
Venous thrombosis	12.80	10.08	41	187071	4425	50413587
Injection site pustule	12.80	10.08	6	187106	68	50417944
Blood culture positive	12.76	10.08	40	187072	4268	50413744
Obstructive airways disorder	12.75	10.08	24	187088	15628	50402384
Pulmonary calcification	12.74	10.08	9	187103	231	50417781
Colitis ulcerative	12.74	10.08	27	187085	16827	50401185
Factor V inhibition	12.72	10.08	8	187104	168	50417844
Extrasystoles	12.68	10.08	42	187070	4613	50413399
Application site irritation	12.66	10.08	22	187090	1593	50416419
Irritability	12.63	10.08	58	187054	28368	50389644
Left ventricular failure	12.59	10.08	43	187069	4798	50413214
Colonoscopy	12.56	10.08	20	187092	1347	50416665
Anger	12.56	10.08	14	187098	11319	50406693
Affect lability	12.51	10.08	9	187103	8989	50409023
Lip haemorrhage	12.50	10.08	12	187100	478	50417534
Dry mouth	12.50	10.08	140	186972	56038	50361974
Status epilepticus	12.35	10.08	19	187093	13387	50404625
Grip strength decreased	12.34	10.08	16	187096	12105	50405907
Arteriovenous fistula site haemorrhage	12.32	10.08	8	187104	178	50417834
Cardiac tamponade	12.27	10.08	39	187073	4193	50413819
Schizophrenia	12.25	10.08	6	187106	7391	50410621
Hospice care	12.25	10.08	48	187064	5724	50412288
Poisoning deliberate	12.25	10.08	7	187105	7905	50410107
Transient ischaemic attack	12.24	10.08	177	186935	32033	50385979
Blood blister	12.22	10.08	22	187090	1638	50416374
Renal stone removal	12.18	10.08	7	187105	124	50417888
Wheezing	12.14	10.08	159	186953	61888	50356124
Crying	12.11	10.08	37	187075	20379	50397633
Blood urea increased	12.10	10.08	137	186975	23448	50394564
Pulmonary artery dilatation	12.09	10.08	9	187103	251	50417761
Conjunctivitis	12.09	10.08	26	187086	16119	50401893
Inadequate diet	12.03	10.08	7	187105	127	50417885
Multiple injuries	11.98	10.08	22	187090	1664	50416348
Injection site mass	11.95	10.08	25	187087	15655	50402357
Maternal exposure before pregnancy	11.90	10.08	3	187109	5594	50412418
Bone marrow failure	11.90	10.08	57	187055	27567	50390445
Coagulation time abnormal	11.88	10.08	6	187106	81	50417931
Long QT syndrome congenital	11.87	10.08	5	187107	43	50417969
Incarcerated umbilical hernia	11.85	10.08	4	187108	17	50417995
Bone disorder	11.84	10.08	33	187079	18719	50399293
Duodenal ulcer	11.77	10.08	53	187059	6722	50411290
Large intestinal haemorrhage	11.77	10.08	18	187094	1171	50416841
Heart rate abnormal	11.76	10.08	37	187075	3955	50414057
Iliac artery embolism	11.74	10.08	3	187109	3	50418009
Vascular stenosis	11.70	10.08	9	187103	264	50417748
Subcapsular renal haematoma	11.67	10.08	9	187103	265	50417747
Immune reconstitution inflammatory syndrome	11.65	10.08	3	187109	5513	50412499
Hyperhidrosis	11.63	10.08	247	186865	89179	50328833
Tricuspid valve incompetence	11.61	10.08	84	187028	12686	50405326
Pathological fracture	11.60	10.08	7	187105	7675	50410337
Hypophagia	11.60	10.08	155	186957	27573	50390439
Renal impairment	11.59	10.08	364	186748	75297	50342715
Visual impairment	11.58	10.08	180	186932	68095	50349917
Herpes simplex	11.57	10.08	6	187106	7156	50410856
Pelvic haemorrhage	11.57	10.08	7	187105	137	50417875
Occult blood	11.57	10.08	18	187094	1189	50416823
Blood creatinine increased	11.56	10.08	366	186746	75794	50342218
Urine output decreased	11.55	10.08	72	187040	10349	50407663
Peritonitis	11.54	10.08	25	187087	15461	50402551
Cardiac output increased	11.52	10.08	7	187105	138	50417874
Atrioventricular block	11.50	10.08	51	187061	6427	50411585
Joint effusion	11.48	10.08	19	187093	13002	50405010
Clostridium difficile infection	11.39	10.08	144	186968	25295	50392717
Unintentional medical device removal	11.39	10.08	3	187109	5432	50412580
Cerebellar haematoma	11.38	10.08	10	187102	355	50417657
Metastases to central nervous system	11.38	10.08	15	187097	11267	50406745
Spinal cord haemorrhage	11.37	10.08	8	187104	204	50417808
Prescribed overdose	11.36	10.08	23	187089	14577	50403435
Catheter site mass	11.32	10.08	4	187108	20	50417992
Cardiac resynchronisation therapy	11.32	10.08	4	187108	20	50417992
Hepatic steatosis	11.29	10.08	49	187063	24335	50393677
Infusion site induration	11.27	10.08	15	187097	858	50417154
Heart valve incompetence	11.27	10.08	26	187086	2313	50415699
Colitis microscopic	11.24	10.08	5	187107	6515	50411497
Lymphadenopathy	11.24	10.08	75	187037	33424	50384588
Pre-eclampsia	11.24	10.08	8	187104	8036	50409976
Aspiration pleural cavity	11.22	10.08	14	187098	751	50417261
Sporotrichosis	11.16	10.08	4	187108	21	50417991
Acute generalised exanthematous pustulosis	11.10	10.08	10	187102	8928	50409084
Productive cough	11.05	10.08	264	186848	52430	50365582
Haemorrhage urinary tract	11.02	10.08	14	187098	765	50417247
Tinnitus	11.01	10.08	60	187052	28072	50389940
Hypercreatininaemia	11.01	10.08	10	187102	371	50417641
Peripheral embolism	11.00	10.08	17	187095	1116	50416896
Diabetes mellitus	10.98	10.08	122	186990	48911	50369101
Thyroiditis acute	10.98	10.08	6	187106	96	50417916
Biopsy liver	10.96	10.08	10	187102	373	50417639
Pulmonary arterial wedge pressure increased	10.95	10.08	9	187103	291	50417721
Liver function test increased	10.93	10.08	53	187059	25553	50392459
Embolic stroke	10.93	10.08	33	187079	3451	50414561
Oxygen consumption	10.92	10.08	6	187106	97	50417915
Cardiac output decreased	10.91	10.08	15	187097	885	50417127
Transaminases abnormal	10.88	10.08	12	187100	564	50417448
Uveitis	10.88	10.08	11	187101	9299	50408713
Infective pulmonary exacerbation of cystic fibrosis	10.88	10.08	8	187104	7901	50410111
Arteriovenous fistula operation	10.85	10.08	8	187104	220	50417792
Liver function test abnormal	10.83	10.08	227	186885	44112	50373900
Osteonecrosis of jaw	10.83	10.08	73	187039	32453	50385559
Dermatitis allergic	10.81	10.08	19	187093	12701	50405311
Blood pressure systolic decreased	10.81	10.08	46	187066	5693	50412319
Influenza	10.78	10.08	419	186693	89119	50328893
Metastases to lung	10.76	10.08	15	187097	11005	50407007
Localised oedema	10.76	10.08	41	187071	4826	50413186
Emotional distress	10.75	10.08	62	187050	28601	50389411
Angina pectoris	10.73	10.08	55	187057	26133	50391879
Joint range of motion decreased	10.66	10.08	34	187078	18478	50399534
Malignant melanoma	10.65	10.08	13	187099	10095	50407917
Procedural pain	10.59	10.08	22	187090	13810	50404202
Breast haemorrhage	10.58	10.08	7	187105	161	50417851
Renal haemorrhage	10.57	10.08	14	187098	797	50417215
Incision site haemorrhage	10.56	10.08	11	187101	484	50417528
Diuretic therapy	10.56	10.08	6	187106	104	50417908
Blood pressure orthostatic abnormal	10.54	10.08	3	187109	6	50418006
Oral candidiasis	10.51	10.08	30	187082	16885	50401127
Paraplegia	10.45	10.08	26	187086	2428	50415584
Adnexal torsion	10.39	10.08	8	187104	235	50417777
Nightmare	10.39	10.08	28	187084	16058	50401954
Pulmonary pain	10.36	10.08	25	187087	2290	50415722
Catheter site hypersensitivity	10.36	10.08	6	187106	108	50417904
Premature baby	10.34	10.08	34	187078	18303	50399709
Aortic surgery	10.32	10.08	4	187108	27	50417985
Pulmonary resection	10.32	10.08	4	187108	27	50417985
Photophobia	10.32	10.08	25	187087	14862	50403150
Myoclonus	10.27	10.08	24	187088	14446	50403566
Incorrect route of product administration	10.26	10.08	35	187077	18631	50399381
Right atrial dilatation	10.24	10.08	12	187100	603	50417409
5-hydroxyindolacetic acid increased	10.23	10.08	3	187109	7	50418005
Infusion site discolouration	10.13	10.08	12	187100	610	50417402
Vessel puncture site haemorrhage	10.12	10.08	6	187106	113	50417899
Heart transplant	10.12	10.08	10	187102	413	50417599
Thrombocytopenia	10.09	10.08	378	186734	127295	50290717

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
International normalised ratio increased	10690.92	10.68	5089	157401	39283	29372754
Gastric haemorrhage	1962.90	10.68	978	161512	8319	29403718
Haemorrhage	1895.22	10.68	1734	160756	43338	29368699
International normalised ratio abnormal	1738.31	10.68	643	161847	2320	29409717
International normalised ratio decreased	1140.47	10.68	525	161965	3665	29408372
Gastrointestinal haemorrhage	1002.57	10.68	1664	160826	77869	29334168
Anticoagulation drug level above therapeutic	902.70	10.68	350	162140	1481	29410556
Drug interaction	798.05	10.68	2637	159853	194748	29217289
Haematuria	689.62	10.68	1020	161470	43119	29368918
Haematoma	688.05	10.68	739	161751	22473	29389564
Subdural haematoma	651.02	10.68	641	161849	17552	29394485
Melaena	590.13	10.68	790	161700	30386	29381651
Haemorrhage intracranial	568.57	10.68	538	161952	14004	29398033
Epistaxis	492.03	10.68	958	161532	50746	29361291
Anticoagulation drug level below therapeutic	470.21	10.68	167	162323	518	29411519
International normalised ratio fluctuation	444.20	10.68	179	162311	856	29411181
Calciphylaxis	403.44	10.68	166	162324	846	29411191
Labelled drug-drug interaction medication error	354.68	10.68	384	162106	11775	29400262
Cerebral haemorrhage	323.08	10.68	602	161888	30824	29381213
Rectal haemorrhage	313.79	10.68	628	161862	33921	29378116
Febrile neutropenia	307.64	10.68	116	162374	112124	29299913
Anaemia	307.55	10.68	2021	160469	198930	29213107
Haemoglobin decreased	302.67	10.68	1288	161202	107087	29304950
Prothrombin time prolonged	280.75	10.68	292	162198	8540	29403497
Off label use	271.59	10.68	804	161686	299996	29112041
Drug ineffective	253.13	10.68	1083	161407	362087	29049950
Drug abuse	250.19	10.68	65	162425	79818	29332219
Haemoptysis	249.96	10.68	532	161958	30018	29382019
Muscle haemorrhage	241.55	10.68	177	162313	3185	29408852
Coagulopathy	234.83	10.68	382	162108	17525	29394512
Fall	233.10	10.68	1718	160772	175460	29236577
Pyrexia	230.10	10.68	811	161679	286811	29125226
Cardiac failure congestive	229.97	10.68	931	161559	75650	29336387
Subarachnoid haemorrhage	204.07	10.68	259	162231	9433	29402604
Faeces discoloured	201.73	10.68	304	162186	13047	29398990
Upper gastrointestinal haemorrhage	194.92	10.68	395	162095	21519	29390518
Abdominal wall haematoma	192.87	10.68	117	162373	1510	29410527
Retroperitoneal haematoma	180.48	10.68	129	162361	2229	29409808
Cardiac failure	172.19	10.68	876	161614	78411	29333626
Contusion	166.72	10.68	460	162030	30635	29381402
Pulmonary arterial hypertension	163.10	10.68	203	162287	7246	29404791
Neutropenia	161.82	10.68	298	162192	131413	29280624
Subdural haemorrhage	157.22	10.68	128	162362	2707	29409330
Haematocrit decreased	151.31	10.68	425	162065	28597	29383440
Retroperitoneal haemorrhage	148.60	10.68	118	162372	2405	29409632
Ecchymosis	146.98	10.68	177	162313	6103	29405934
Fluid retention	135.79	10.68	358	162132	23202	29388835
Coagulation time prolonged	130.68	10.68	82	162408	1128	29410909
Foetal warfarin syndrome	130.50	10.68	31	162459	0	29412037
Haematemesis	129.72	10.68	362	162128	24264	29387773
Product use in unapproved indication	125.00	10.68	177	162313	86698	29325339
Depression	121.01	10.68	175	162315	84972	29327065
Atrial fibrillation	115.80	10.68	983	161507	104663	29307374
Haemarthrosis	115.74	10.68	107	162383	2699	29409338
Intra-abdominal haematoma	114.89	10.68	75	162415	1109	29410928
Intraventricular haemorrhage	105.01	10.68	103	162387	2803	29409234
Right ventricular failure	101.63	10.68	167	162323	7723	29404314
Thrombosis	100.02	10.68	485	162005	42560	29369477
Lower gastrointestinal haemorrhage	98.01	10.68	168	162322	8045	29403992
Transfusion	96.07	10.68	156	162334	7142	29404895
Pulmonary hypertension	93.56	10.68	269	162221	18339	29393698
Head injury	90.26	10.68	242	162248	15839	29396198
Occult blood positive	88.85	10.68	106	162384	3618	29408419
Intentional overdose	88.18	10.68	51	162439	38477	29373560
Mucosal inflammation	85.87	10.68	33	162457	31562	29380475
Ear haemorrhage	83.86	10.68	54	162436	779	29411258
Leukopenia	81.85	10.68	110	162380	55093	29356944
Spinal epidural haematoma	81.60	10.68	36	162454	224	29411813
Dyspnoea	81.22	10.68	2358	160132	324374	29087663
Shock haemorrhagic	81.17	10.68	169	162321	9382	29402655
Completed suicide	81.17	10.68	241	162249	90005	29322032
Blood loss anaemia	79.41	10.68	143	162347	7123	29404914
Intestinal haematoma	77.72	10.68	25	162465	51	29411986
Malignant neoplasm progression	77.22	10.68	183	162307	73676	29338361
Suicide attempt	75.46	10.68	47	162443	34063	29377974
Gingival bleeding	74.39	10.68	130	162360	6323	29405714
Infusion related reaction	74.05	10.68	79	162411	43807	29368230
Agitation	72.30	10.68	106	162384	51198	29360839
Cerebral mass effect	71.60	10.68	50	162440	831	29411206
Anaphylactic reaction	71.36	10.68	31	162459	27542	29384495
Pulmonary alveolar haemorrhage	70.29	10.68	126	162364	6254	29405783
Foetal exposure during pregnancy	67.83	10.68	52	162438	33815	29378222
Pancytopenia	67.17	10.68	233	162257	82935	29329102
Anticoagulant-related nephropathy	66.06	10.68	18	162472	13	29412024
Deep vein thrombosis	65.95	10.68	540	161950	56859	29355178
Activated partial thromboplastin time prolonged	64.64	10.68	136	162354	7606	29404431
Drug dependence	63.88	10.68	18	162472	20963	29391074
Pain in jaw	62.15	10.68	172	162318	11469	29400568
Haematoma muscle	61.21	10.68	47	162443	910	29411127
Cardiac tamponade	60.90	10.68	99	162391	4536	29407501
Compartment syndrome	60.49	10.68	71	162419	2381	29409656
Dizziness	60.34	10.68	1415	161075	188269	29223768
Haemorrhage subcutaneous	60.01	10.68	66	162424	2059	29409978
Extradural haematoma	59.36	10.68	49	162441	1057	29410980
Oedema	59.05	10.68	403	162087	40080	29371957
Thrombocytopenia	59.00	10.68	466	162024	134357	29277680
Prothrombin time ratio increased	58.99	10.68	23	162467	99	29411938
Intentional product use issue	58.72	10.68	89	162401	42409	29369628
Drug hypersensitivity	58.41	10.68	187	162303	68219	29343818
Skin necrosis	56.52	10.68	100	162390	4912	29407125
Therapeutic product effect incomplete	55.58	10.68	81	162409	39224	29372813
Product use issue	54.93	10.68	126	162364	51318	29360719
Seizure	54.90	10.68	294	162196	92829	29319208
Conjunctival haemorrhage	54.53	10.68	70	162420	2578	29409459
Heparin-induced thrombocytopenia	54.42	10.68	98	162392	4881	29407156
Stomatitis	53.95	10.68	75	162415	37038	29374999
Neutrophil count decreased	53.91	10.68	98	162392	43469	29368568
Cytokine release syndrome	53.75	10.68	5	162485	13114	29398923
Appendicolith	53.64	10.68	80	162410	3400	29408637
Acute myeloid leukaemia	52.49	10.68	13	162477	16500	29395537
Transient ischaemic attack	52.46	10.68	260	162230	23010	29389027
Hypervolaemia	52.31	10.68	213	162277	17332	29394705
COVID-19	52.13	10.68	73	162417	35941	29376096
Oedema peripheral	51.83	10.68	828	161662	102729	29309308
Cerebrovascular accident	51.77	10.68	648	161842	76263	29335774
Toxicity to various agents	51.52	10.68	659	161831	173002	29239035
Aggression	51.48	10.68	72	162418	35469	29376568
Cytomegalovirus infection	51.33	10.68	32	162458	23183	29388854
Cardiac failure chronic	50.99	10.68	111	162379	6356	29405681
Post procedural haemorrhage	50.66	10.68	121	162369	7370	29404667
Arthralgia	50.35	10.68	507	161983	139110	29272927
Haemorrhagic stroke	50.21	10.68	104	162386	5752	29406285
Haemoperitoneum	49.72	10.68	52	162438	1530	29410507
Device alarm issue	49.58	10.68	34	162456	548	29411489
Ventricular tachycardia	49.32	10.68	250	162240	22324	29389713
General physical health deterioration	49.03	10.68	347	162143	102510	29309527
Suicidal ideation	48.64	10.68	72	162418	34644	29377393
Synovitis	47.86	10.68	3	162487	10887	29401150
Catheter site erythema	47.68	10.68	45	162445	1166	29410871
Rheumatoid arthritis	46.70	10.68	65	162425	32087	29379950
Scrotal haematoma	46.44	10.68	18	162472	76	29411961
Asthma	45.69	10.68	72	162418	33777	29378260
Dyspnoea exertional	45.57	10.68	350	162140	36140	29375897
Cerebellar haemorrhage	45.43	10.68	47	162443	1365	29410672
Gastritis erosive	45.33	10.68	95	162395	5298	29406739
Traumatic haematoma	44.64	10.68	34	162456	650	29411387
Pain	44.60	10.68	668	161822	170764	29241273
Rash	44.26	10.68	755	161735	189064	29222973
White blood cell count decreased	43.86	10.68	273	162217	83089	29328948
Gastric ulcer	43.75	10.68	173	162317	13888	29398149
Intentional product misuse	43.75	10.68	77	162413	34584	29377453
Haematochezia	43.58	10.68	350	162140	36633	29375404
Mesenteric haematoma	43.53	10.68	13	162477	18	29412019
Cholestasis	43.31	10.68	39	162451	23423	29388614
Chills	43.18	10.68	223	162267	71077	29340960
Angioedema	42.97	10.68	68	162422	31847	29380190
Rash maculo-papular	42.92	10.68	42	162448	24247	29387790
Catheter management	42.42	10.68	36	162454	808	29411229
Spontaneous haematoma	42.25	10.68	29	162461	468	29411569
Urticaria	42.20	10.68	156	162334	54504	29357533
Hepatocellular injury	42.05	10.68	33	162457	21210	29390827
Gastrointestinal arteriovenous malformation	41.18	10.68	25	162465	323	29411714
Colitis	40.74	10.68	68	162422	31180	29380857
Prothrombin time abnormal	39.84	10.68	29	162461	516	29411521
Pancreatitis	39.77	10.68	81	162409	34433	29377604
Alanine aminotransferase increased	39.60	10.68	228	162262	70716	29341321
Gastric ulcer haemorrhage	39.49	10.68	85	162405	4829	29407208
Drug intolerance	39.40	10.68	135	162355	48244	29363793
Device interaction	39.37	10.68	29	162461	526	29411511
Somnolence	39.12	10.68	329	162161	93626	29318411
Generalised tonic-clonic seizure	38.82	10.68	29	162461	19110	29392927
Cardiac failure acute	38.81	10.68	125	162365	9067	29402970
Lymphopenia	38.70	10.68	13	162477	13520	29398517
Mallory-Weiss syndrome	38.40	10.68	41	162449	1236	29410801
Hyphaema	38.04	10.68	27	162463	461	29411576
Chest wall haematoma	37.99	10.68	18	162472	135	29411902
Mouth haemorrhage	37.64	10.68	82	162408	4698	29407339
Injection site pain	37.51	10.68	76	162414	32370	29379667
Diabetic ketoacidosis	37.16	10.68	21	162469	16052	29395985
Thrombosis in device	36.80	10.68	64	162426	3100	29408937
Hyperhidrosis	36.79	10.68	206	162284	64334	29347703
Hypotension	36.53	10.68	1358	161132	192996	29219041
Aspergillus infection	36.33	10.68	7	162483	10574	29401463
Penile necrosis	36.20	10.68	13	162477	42	29411995
Anxiety	35.95	10.68	298	162192	85067	29326970
Exposure during pregnancy	35.75	10.68	3	162487	8551	29403486
Bone marrow failure	35.54	10.68	60	162430	27389	29384648
Disease progression	35.39	10.68	284	162206	81632	29330405
Atrial flutter	34.76	10.68	160	162330	13734	29398303
Subarachnoid haematoma	34.73	10.68	14	162476	67	29411970
Disturbance in attention	34.55	10.68	40	162450	21384	29390653
Myelosuppression	34.52	10.68	12	162478	12215	29399822
Haematoma evacuation	34.48	10.68	18	162472	170	29411867
Venous pressure jugular increased	34.42	10.68	30	162460	699	29411338
Pelvic haematoma	34.23	10.68	16	162474	116	29411921
Diverticulum intestinal haemorrhagic	34.09	10.68	49	162441	2013	29410024
Pancreatitis acute	33.74	10.68	51	162439	24334	29387703
Hypertension	33.26	10.68	446	162044	116168	29295869
Renal haemorrhage	33.24	10.68	38	162452	1238	29410799
International normalised ratio	33.14	10.68	12	162478	40	29411997
Lymphadenopathy	33.13	10.68	54	162436	24995	29387042
Catheter site haemorrhage	32.89	10.68	48	162442	2000	29410037
Psoriasis	32.75	10.68	81	162409	32146	29379891
Hypercoagulation	32.73	10.68	35	162455	1057	29410980
Subcutaneous haematoma	32.58	10.68	32	162458	872	29411165
Serotonin syndrome	32.45	10.68	29	162461	17483	29394554
Abnormal behaviour	32.36	10.68	48	162442	23079	29388958
Neoplasm progression	31.95	10.68	33	162457	18579	29393458
Psychotic disorder	31.76	10.68	39	162451	20315	29391722
Thalamus haemorrhage	31.76	10.68	32	162458	900	29411137
Bronchopulmonary aspergillosis	31.74	10.68	14	162476	12330	29399707
Cardiogenic shock	31.61	10.68	197	162293	18993	29393044
Cardiac pacemaker insertion	31.29	10.68	52	162438	2427	29409610
Pruritus	30.80	10.68	454	162036	116395	29295642
Therapeutic product effect decreased	30.73	10.68	73	162417	29378	29382659
Internal haemorrhage	30.47	10.68	72	162418	4355	29407682
Catheter site discharge	30.38	10.68	25	162465	537	29411500
Blood urine present	30.33	10.68	120	162370	9635	29402402
Haemophagocytic lymphohistiocytosis	30.19	10.68	10	162480	10494	29401543
Choroidal haemorrhage	30.18	10.68	12	162478	55	29411982
Coma	30.18	10.68	113	162377	39337	29372700
Traumatic intracranial haemorrhage	30.14	10.68	26	162464	597	29411440
Infection	30.06	10.68	273	162217	76478	29335559
Restlessness	29.98	10.68	47	162443	22098	29389939
Hepatic cytolysis	29.79	10.68	5	162485	8342	29403695
Oxygen consumption increased	29.66	10.68	36	162454	1251	29410786
Accidental exposure to product	29.60	10.68	11	162479	10742	29401295
Syncope	29.58	10.68	619	161871	80752	29331285
Atrial thrombosis	29.55	10.68	45	162445	1948	29410089
Tremor	29.49	10.68	260	162230	73278	29338759
Sleep disorder	29.15	10.68	56	162434	24330	29387707
Small intestinal haemorrhage	28.89	10.68	44	162446	1905	29410132
Hypokalaemia	28.73	10.68	160	162330	50043	29361994
Posterior reversible encephalopathy syndrome	28.66	10.68	7	162483	8969	29403068
Anticoagulation drug level decreased	28.57	10.68	12	162478	65	29411972
Extrapyramidal disorder	28.30	10.68	12	162478	10819	29401218
Musculoskeletal stiffness	28.20	10.68	108	162382	37350	29374687
Gamma-glutamyltransferase increased	28.11	10.68	66	162424	26671	29385366
Arteriovenous malformation	27.50	10.68	26	162464	675	29411362
Pericardial haemorrhage	27.45	10.68	54	162436	2877	29409160
Mediastinal haematoma	27.38	10.68	13	162477	98	29411939
Neuroleptic malignant syndrome	27.30	10.68	29	162461	16119	29395918
Aspartate aminotransferase increased	27.22	10.68	204	162286	59521	29352516
Premature baby	27.08	10.68	33	162457	17247	29394790
Tumour lysis syndrome	26.94	10.68	22	162468	13862	29398175
Blue toe syndrome	26.93	10.68	14	162476	131	29411906
Treatment failure	26.85	10.68	108	162382	36831	29375206
C-reactive protein increased	26.47	10.68	139	162351	44124	29367913
Irritability	26.36	10.68	51	162439	22101	29389936
Multiple sclerosis relapse	26.28	10.68	15	162475	11404	29400633
Insomnia	26.20	10.68	337	162153	88424	29323613
Blood pressure fluctuation	26.20	10.68	43	162447	19851	29392186
Hyperbilirubinaemia	26.18	10.68	26	162464	14908	29397129
Lymphocyte count decreased	26.00	10.68	41	162449	19230	29392807
Vomiting	25.90	10.68	930	161560	211330	29200707
Sinusitis	25.88	10.68	99	162391	34251	29377786
Dyskinesia	25.83	10.68	44	162446	20017	29392020
Duodenal ulcer haemorrhage	25.73	10.68	68	162422	4411	29407626
Implant site haematoma	25.68	10.68	11	162479	63	29411974
Hypertriglyceridaemia	25.54	10.68	5	162485	7470	29404567
Food interaction	25.50	10.68	28	162462	872	29411165
Haemorrhagic diathesis	25.45	10.68	49	162441	2569	29409468
Medical device change	25.44	10.68	12	162478	89	29411948
Atheroembolism	25.44	10.68	16	162474	221	29411816
Cardioversion	25.34	10.68	27	162463	812	29411225
Drug resistance	25.28	10.68	50	162440	21490	29390547
Hyperthyroidism	25.26	10.68	104	162386	8504	29403533
Death	25.17	10.68	1582	160908	340502	29071535
Product administration error	24.89	10.68	149	162341	14161	29397876
Asthenia	24.62	10.68	1431	161059	213819	29198218
Cerebral haematoma	24.45	10.68	65	162425	4231	29407806
Pneumonitis	24.39	10.68	76	162414	27968	29384069
Substance abuse	24.36	10.68	4	162486	6783	29405254
Therapeutic product effect increased	24.33	10.68	23	162467	597	29411440
Pneumocystis jirovecii pneumonia	24.29	10.68	34	162456	16745	29395292
Coagulation time shortened	24.05	10.68	15	162475	204	29411833
Colonic haematoma	24.00	10.68	9	162481	34	29412003
Diverticulum	23.97	10.68	83	162407	6249	29405788
Haemorrhoidal haemorrhage	23.89	10.68	52	162438	2977	29409060
Nausea	23.88	10.68	1323	161167	287932	29124105
Hypochromasia	23.87	10.68	17	162473	292	29411745
Peripheral swelling	23.85	10.68	487	162003	63252	29348785
Cerebral artery embolism	23.82	10.68	26	162464	804	29411233
Haemothorax	23.77	10.68	56	162434	3380	29408657
Lung transplant	23.74	10.68	38	162452	1718	29410319
Neutrophil count increased	23.26	10.68	28	162462	14714	29397323
Epilepsy	23.21	10.68	41	162449	18391	29393646
Immune reconstitution inflammatory syndrome	23.19	10.68	7	162483	7795	29404242
Hepatotoxicity	23.18	10.68	39	162451	17828	29394209
Psoriatic arthropathy	23.08	10.68	28	162462	14663	29397374
Embolic stroke	23.05	10.68	57	162433	3549	29408488
Medical device site thrombosis	22.97	10.68	8	162482	23	29412014
Duodenal ulcer	22.83	10.68	106	162384	9132	29402905
Laryngeal haematoma	22.82	10.68	13	162477	148	29411889
Adrenal haemorrhage	22.79	10.68	14	162476	185	29411852
Anger	22.74	10.68	16	162474	10874	29401163
Intentional self-injury	22.65	10.68	21	162469	12440	29399597
Hepatic enzyme increased	22.61	10.68	102	162388	33697	29378340
Haemorrhagic cholecystitis	22.56	10.68	10	162480	63	29411974
Intracardiac thrombus	22.36	10.68	43	162447	2252	29409785
Sinus tachycardia	22.35	10.68	30	162460	15039	29396998
Septic shock	22.17	10.68	228	162262	62332	29349705
Dystonia	22.16	10.68	13	162477	9736	29402301
Hypocoagulable state	22.15	10.68	26	162464	872	29411165
Potentiating drug interaction	22.15	10.68	64	162426	4374	29407663
Hypersensitivity	22.11	10.68	185	162305	52718	29359319
Joint swelling	21.92	10.68	171	162319	49459	29362578
Product dose omission issue	21.88	10.68	385	162105	95998	29316039
Intraocular haematoma	21.85	10.68	7	162483	14	29412023
Aplastic anaemia	21.85	10.68	7	162483	7503	29404534
Pulmonary embolism	21.58	10.68	562	161928	75972	29336065
Catheter site pruritus	21.50	10.68	16	162474	295	29411742
Purpura	21.41	10.68	104	162386	9128	29402909
Depressed mood	21.25	10.68	36	162454	16412	29395625
Hepatic failure	21.14	10.68	95	162395	31417	29380620
Haemorrhagic arteriovenous malformation	20.86	10.68	17	162473	360	29411677
Blood pressure increased	20.76	10.68	283	162207	73520	29338517
Fat embolism	20.71	10.68	13	162477	179	29411858
Infusion site pain	20.60	10.68	48	162442	2877	29409160
Product complaint	20.59	10.68	71	162419	5334	29406703
Encephalitis	20.56	10.68	5	162485	6425	29405612
Spinal subdural haematoma	20.53	10.68	9	162481	55	29411982
Labelled drug-disease interaction medication error	20.53	10.68	11	162479	110	29411927
Cardiac operation	20.50	10.68	45	162445	2591	29409446
Complication associated with device	20.49	10.68	69	162421	5122	29406915
Gravitational oedema	20.48	10.68	20	162470	541	29411496
Hyperkalaemia	20.37	10.68	461	162029	60931	29351106
Intra-abdominal haemorrhage	20.11	10.68	39	162451	2056	29409981
Neuropathy peripheral	20.10	10.68	272	162218	70755	29341282
Drug withdrawal syndrome	20.04	10.68	43	162447	17941	29394096
Cytomegalovirus viraemia	20.04	10.68	5	162485	6315	29405722
Transplant rejection	19.95	10.68	13	162477	9199	29402838
Sedation	19.91	10.68	41	162449	17364	29394673
Apallic syndrome	19.83	10.68	14	162476	237	29411800
Infusion site erythema	19.80	10.68	34	162456	1630	29410407
Catheter site pain	19.74	10.68	28	162462	1136	29410901
Appendicitis	19.71	10.68	98	162392	8681	29403356
Drug reaction with eosinophilia and systemic symptoms	19.62	10.68	83	162407	27909	29384128
Antiphospholipid syndrome	19.47	10.68	17	162473	397	29411640
Withdrawal syndrome	19.43	10.68	19	162471	10973	29401064
Haemobilia	19.42	10.68	15	162475	293	29411744
Large intestinal ulcer haemorrhage	19.38	10.68	10	162480	92	29411945
Herpes zoster	19.32	10.68	92	162398	29960	29382077
Sopor	19.11	10.68	114	162376	10820	29401217
Rash erythematous	19.06	10.68	58	162432	21504	29390533
Hepatic steatosis	19.04	10.68	33	162457	14913	29397124
Hepatitis	19.02	10.68	55	162435	20728	29391309
Injection site reaction	19.02	10.68	20	162470	11168	29400869
Prostate cancer	18.95	10.68	74	162416	25453	29386584
Hypercholesterolaemia	18.94	10.68	8	162482	7230	29404807
Splenic haematoma	18.94	10.68	12	162478	168	29411869
Protein S deficiency	18.93	10.68	10	162480	97	29411940
Hallucination, auditory	18.86	10.68	15	162475	9578	29402459
Neurotoxicity	18.86	10.68	32	162458	14581	29397456
Hypoprothrombinaemia	18.82	10.68	16	162474	360	29411677
Anticoagulation drug level increased	18.77	10.68	18	162472	476	29411561
Pericarditis uraemic	18.73	10.68	6	162484	12	29412025
Mitral valve replacement	18.60	10.68	11	162479	135	29411902
Psychomotor hyperactivity	18.60	10.68	11	162479	8202	29403835
Hepatic rupture	18.55	10.68	7	162483	27	29412010
Acute generalised exanthematous pustulosis	18.53	10.68	4	162486	5579	29406458
Pulmonary endarterectomy	18.51	10.68	9	162481	72	29411965
Radiation proctitis	18.40	10.68	9	162481	73	29411964
Akathisia	18.38	10.68	7	162483	6735	29405302
Paraesthesia	18.36	10.68	198	162292	53647	29358390
Heart valve replacement	18.35	10.68	15	162475	319	29411718
Craniotomy	18.30	10.68	9	162481	74	29411963
Large intestinal haemorrhage	18.21	10.68	31	162459	1476	29410561
Pathogen resistance	18.20	10.68	11	162479	8105	29403932
Hepatitis B	18.12	10.68	4	162486	5493	29406544
Protein C decreased	18.11	10.68	6	162484	14	29412023
Diffuse large B-cell lymphoma	17.99	10.68	6	162484	6270	29405767
Blood cholinesterase decreased	17.93	10.68	10	162480	109	29411928
Congestive hepatopathy	17.80	10.68	33	162457	1681	29410356
Tongue haematoma	17.77	10.68	10	162480	111	29411926
Brain herniation	17.75	10.68	52	162438	3581	29408456
Pharyngeal haematoma	17.72	10.68	8	162482	53	29411984
Chest tube insertion	17.70	10.68	9	162481	80	29411957
Central venous catheterisation	17.69	10.68	25	162465	1011	29411026
Muscle strain	17.68	10.68	51	162439	3482	29408555
Prothrombin level increased	17.55	10.68	11	162479	151	29411886
Paranoia	17.54	10.68	17	162473	9860	29402177
Vitamin K deficiency	17.45	10.68	13	162477	240	29411797
Prothrombin level abnormal	17.42	10.68	9	162481	83	29411954
Nephropathy	17.39	10.68	66	162424	5197	29406840
Renal haematoma	17.35	10.68	17	162473	462	29411575
Mental status changes	17.34	10.68	279	162211	34648	29377389
Catheter site infection	17.32	10.68	36	162454	1996	29410041
Fear	17.30	10.68	16	162474	9488	29402549
Prothrombin time shortened	17.21	10.68	29	162461	1369	29410668
Transplant evaluation	17.17	10.68	17	162473	468	29411569
Hyperglycaemia	17.14	10.68	114	162376	34173	29377864
Catheter placement	17.05	10.68	20	162470	670	29411367
Ventricular hyperkinesia	17.00	10.68	12	162478	203	29411834
Infected skin ulcer	16.92	10.68	29	162461	1388	29410649
Abdominal distension	16.91	10.68	350	162140	45561	29366476
Tracheal calcification	16.84	10.68	4	162486	0	29412037
Therapy partial responder	16.70	10.68	4	162486	5195	29406842
Acute respiratory distress syndrome	16.70	10.68	67	162423	22868	29389169
Blood viscosity decreased	16.67	10.68	8	162482	62	29411975
Weight decreased	16.64	10.68	669	161821	150236	29261801
Hemianopia homonymous	16.62	10.68	20	162470	689	29411348
Gangrene	16.59	10.68	56	162434	4162	29407875
Cardiotoxicity	16.58	10.68	3	162487	4741	29407296
Cardiac ventricular thrombosis	16.54	10.68	23	162467	916	29411121
Alopecia	16.39	10.68	52	162438	19032	29393005
Large intestine polyp	16.31	10.68	75	162415	6434	29405603
Influenza like illness	16.27	10.68	74	162416	24396	29387641
Atrial tachycardia	16.09	10.68	34	162456	1907	29410130
Schizophrenia	16.02	10.68	8	162482	6557	29405480
Bovine tuberculosis	15.99	10.68	9	162481	100	29411937
Sinus node dysfunction	15.96	10.68	51	162439	3683	29408354
Right ventricular diastolic collapse	15.94	10.68	8	162482	69	29411968
Toxic epidermal necrolysis	15.92	10.68	49	162441	18104	29393933
Right atrial enlargement	15.86	10.68	12	162478	227	29411810
Palmar-plantar erythrodysaesthesia syndrome	15.86	10.68	36	162454	14723	29397314
Catheter removal	15.84	10.68	11	162479	181	29411856
Drug ineffective for unapproved indication	15.83	10.68	34	162456	14180	29397857
Haemorrhoids	15.79	10.68	114	162376	11543	29400494
Xanthopsia	15.66	10.68	10	162480	142	29411895
Encephalomalacia	15.65	10.68	20	162470	733	29411304
Sepsis	15.63	10.68	633	161857	142049	29269988
Dry mouth	15.63	10.68	64	162426	21720	29390317
Adrenal insufficiency	15.61	10.68	23	162467	11091	29400946
Implantable defibrillator replacement	15.61	10.68	5	162485	10	29412027
Peptic ulcer	15.59	10.68	39	162451	2446	29409591
Ventricular fibrillation	15.58	10.68	144	162346	15689	29396348
Blood pressure decreased	15.56	10.68	343	162147	45134	29366903
Inflammation	15.55	10.68	68	162422	22660	29389377
Crying	15.54	10.68	5	162485	5346	29406691
Puncture site haematoma	15.43	10.68	10	162480	146	29411891
Anaesthesia	15.42	10.68	7	162483	47	29411990
Hypophagia	15.39	10.68	179	162311	20693	29391344
Hypocalcaemia	15.28	10.68	60	162430	20605	29391432
Obstructive airways disorder	15.28	10.68	23	162467	10993	29401044
Incarcerated hernia	15.25	10.68	10	162480	149	29411888
Medical device site haematoma	15.18	10.68	6	162484	27	29412010
Urinary bladder haemorrhage	15.15	10.68	30	162460	1606	29410431
Adenovirus infection	15.14	10.68	3	162487	4444	29407593
Vascular calcification	15.12	10.68	20	162470	759	29411278
Anal abscess	15.09	10.68	5	162485	5246	29406791
Osteoarthritis	15.08	10.68	50	162440	18053	29393984
Hepatitis C	15.07	10.68	16	162474	8894	29403143
Tongue haemorrhage	15.05	10.68	16	162474	480	29411557
Diabetes mellitus	15.01	10.68	143	162347	39688	29372349
Mouth ulceration	14.97	10.68	21	162469	10334	29401703
Mitral valve thickening	14.95	10.68	14	162476	359	29411678
Hydrocephalus	14.91	10.68	55	162435	4272	29407765
Cerebellar haematoma	14.86	10.68	11	162479	201	29411836
Epstein-Barr virus infection	14.84	10.68	9	162481	6620	29405417
Spinal cord haemorrhage	14.84	10.68	13	162477	305	29411732
Transaminases increased	14.79	10.68	69	162421	22593	29389444
Hyperthermia	14.78	10.68	18	162472	9412	29402625
Muscle rigidity	14.72	10.68	18	162472	9393	29402644
Aortic stenosis	14.70	10.68	51	162439	3843	29408194
Cardiac disorder	14.70	10.68	287	162203	36976	29375061
Gastrointestinal erosion	14.61	10.68	14	162476	370	29411667
Polyneuropathy	14.44	10.68	28	162462	12124	29399913
Pulmonary calcification	14.43	10.68	10	162480	164	29411873
Femoral nerve palsy	14.36	10.68	6	162484	32	29412005
Heart valve operation	14.29	10.68	7	162483	57	29411980
Hepatic haematoma	14.27	10.68	14	162476	381	29411656
Mental disorder	14.26	10.68	31	162459	12874	29399163
Injection site erythema	14.23	10.68	35	162455	13921	29398116
Blood glucose increased	14.23	10.68	233	162257	58751	29353286
Strangury	14.21	10.68	9	162481	126	29411911
Pneumonia fungal	14.16	10.68	7	162483	5770	29406267
Myocarditis	14.13	10.68	24	162466	10932	29401105
Eye haematoma	14.09	10.68	7	162483	59	29411978
Periorbital haematoma	14.06	10.68	13	162477	328	29411709
Incision site haematoma	13.98	10.68	8	162482	92	29411945
Splenic rupture	13.98	10.68	27	162463	1419	29410618
Neutropenic sepsis	13.95	10.68	27	162463	11700	29400337
Aortic bruit	13.93	10.68	10	162480	174	29411863
Gastrointestinal ulcer	13.92	10.68	29	162461	1610	29410427
Hepatic encephalopathy	13.84	10.68	32	162458	13003	29399034
Cardioactive drug level increased	13.75	10.68	29	162461	1624	29410413
Presyncope	13.71	10.68	142	162348	15947	29396090
Arteriovenous fistula site haemorrhage	13.68	10.68	8	162482	96	29411941
N-telopeptide urine increased	13.64	10.68	6	162484	37	29412000
Jugular vein distension	13.63	10.68	17	162473	608	29411429
Device occlusion	13.60	10.68	64	162426	5544	29406493
Parkinsonism	13.55	10.68	12	162478	7266	29404771
Tumour haemorrhage	13.54	10.68	37	162453	2448	29409589
Procedural site reaction	13.50	10.68	10	162480	183	29411854
Erectile dysfunction	13.50	10.68	52	162438	17957	29394080
Gastrointestinal angiodysplasia	13.39	10.68	16	162474	547	29411490
Blood pressure systolic decreased	13.36	10.68	49	162441	3795	29408242
Subdural haematoma evacuation	13.31	10.68	5	162485	19	29412018
Aortic valve replacement	13.31	10.68	18	162472	698	29411339
Catatonia	13.29	10.68	4	162486	4464	29407573
Emotional distress	13.29	10.68	36	162454	13859	29398178
Haemorrhagic infarction	13.27	10.68	14	162476	416	29411621
Infusion site haemorrhage	13.23	10.68	18	162472	702	29411335
Infusion site warmth	13.20	10.68	8	162482	103	29411934
Cardiac valve disease	13.19	10.68	40	162450	2808	29409229
Delusion	13.19	10.68	26	162464	11190	29400847
Incision site haemorrhage	13.19	10.68	15	162475	486	29411551
Euphoric mood	13.17	10.68	5	162485	4820	29407217
Spinal cord haematoma	13.14	10.68	8	162482	104	29411933
Wheezing	13.10	10.68	118	162372	33122	29378915
Vitreous haemorrhage	13.06	10.68	32	162458	1981	29410056
Mean platelet volume increased	12.98	10.68	14	162476	427	29411610
Lipase increased	12.98	10.68	16	162474	8321	29403716
Fistula	12.94	10.68	6	162484	5133	29406904
Panic attack	12.94	10.68	16	162474	8310	29403727
Orthostatic hypotension	12.86	10.68	185	162305	22444	29389593
Cognitive disorder	12.84	10.68	76	162414	23423	29388614
N-terminal prohormone brain natriuretic peptide increased	12.84	10.68	31	162459	1901	29410136
Ulnar nerve palsy	12.83	10.68	4	162486	7	29412030
Conjunctivitis	12.82	10.68	15	162475	7983	29404054
Oesophageal ulcer	12.78	10.68	42	162448	3078	29408959
Encephalopathy	12.77	10.68	109	162381	30934	29381103
No adverse event	12.76	10.68	51	162439	17427	29394610
Concomitant disease progression	12.71	10.68	35	162455	2326	29409711
Vascular pseudoaneurysm	12.66	10.68	31	162459	1918	29410119
Agranulocytosis	12.65	10.68	63	162427	20277	29391760
Klebsiella infection	12.65	10.68	13	162477	7336	29404701
Wrong technique in product usage process	12.64	10.68	111	162379	31317	29380720
Arteriovenous graft site haemorrhage	12.63	10.68	3	162487	0	29412037
Eye infection intraocular	12.63	10.68	3	162487	0	29412037
Vascular fragility	12.63	10.68	3	162487	0	29412037
Epiphyseal disorder	12.63	10.68	3	162487	0	29412037
Muscle spasms	12.61	10.68	267	162223	64815	29347222
Basal cell carcinoma	12.56	10.68	49	162441	16861	29395176
Electrolyte imbalance	12.53	10.68	27	162463	11247	29400790
Oesophageal pain	12.51	10.68	18	162472	740	29411297
Libido decreased	12.51	10.68	4	162486	4294	29407743
Acute coronary syndrome	12.50	10.68	31	162459	12294	29399743
Obesity	12.36	10.68	22	162468	9841	29402196
Acute cutaneous lupus erythematosus	12.34	10.68	7	162483	79	29411958
Femoral artery aneurysm	12.32	10.68	9	162481	161	29411876
Upper airway obstruction	12.24	10.68	16	162474	600	29411437
Burning feet syndrome	12.19	10.68	7	162483	81	29411956
Walking distance test abnormal	12.18	10.68	9	162481	164	29411873
Mood altered	12.18	10.68	16	162474	8095	29403942
Nightmare	12.15	10.68	28	162462	11389	29400648
Paracentesis	12.15	10.68	13	162477	393	29411644
Ankle deformity	12.10	10.68	10	162480	216	29411821
Dissociation	12.06	10.68	22	162468	1107	29410930
Dizziness exertional	12.04	10.68	8	162482	122	29411915
Peripheral sensory neuropathy	12.04	10.68	9	162481	5930	29406107
Elbow operation	11.99	10.68	8	162482	123	29411914
Night sweats	11.92	10.68	42	162448	14890	29397147
Metabolic acidosis	11.85	10.68	141	162349	37521	29374516
Pulmonary haematoma	11.83	10.68	6	162484	53	29411984
Prothrombin level decreased	11.79	10.68	21	162469	1037	29411000
Enterococcal infection	11.72	10.68	17	162473	8251	29403786
Maternal exposure during pregnancy	11.72	10.68	4	162486	4119	29407918
Enteritis	11.70	10.68	12	162478	6779	29405258
Atrial septal defect	11.69	10.68	12	162478	6777	29405260
Erythema	11.67	10.68	321	162169	75285	29336752
Eyelid ptosis	11.67	10.68	7	162483	5179	29406858
Eye haemorrhage	11.65	10.68	46	162444	3690	29408347
Gout	11.58	10.68	143	162347	16768	29395269
Coagulation test abnormal	11.57	10.68	14	162476	485	29411552
Thrombectomy	11.56	10.68	7	162483	90	29411947
Osteonecrosis of jaw	11.54	10.68	49	162441	16461	29395576
Aplasia	11.45	10.68	4	162486	4059	29407978
Catheter site swelling	11.44	10.68	11	162479	292	29411745
Pulmonary arterial pressure increased	11.39	10.68	21	162469	1065	29410972
Ubiquinone decreased	11.36	10.68	4	162486	12	29412025
Procalcitonin	11.36	10.68	4	162486	12	29412025
Coagulation factor V level increased	11.35	10.68	5	162485	31	29412006
Cellulitis	11.32	10.68	331	162159	45509	29366528
Arterial haemorrhage	11.32	10.68	17	162473	727	29411310
Protein-losing gastroenteropathy	11.31	10.68	11	162479	296	29411741
Illness	11.27	10.68	12	162478	6662	29405375
Bradyarrhythmia	11.26	10.68	30	162460	1955	29410082
COVID-19 pneumonia	11.26	10.68	22	162468	9500	29402537
Cardiac ventricular disorder	11.26	10.68	10	162480	239	29411798
Pseudomonas infection	11.24	10.68	27	162463	10825	29401212
Poisoning deliberate	11.22	10.68	9	162481	5722	29406315
Spinal osteoarthritis	11.22	10.68	11	162479	6345	29405692
Left ventricular failure	11.21	10.68	53	162437	4600	29407437
Normocytic anaemia	11.20	10.68	30	162460	1962	29410075
Lichen planus	11.13	10.68	18	162472	821	29411216
Metastatic carcinoid tumour	11.12	10.68	4	162486	13	29412024
Cardioactive drug level above therapeutic	11.12	10.68	6	162484	61	29411976
Cardiac pseudoaneurysm	11.09	10.68	5	162485	33	29412004
Skin laceration	11.08	10.68	101	162389	10961	29401076
Endarterectomy	11.06	10.68	8	162482	141	29411896
Granulocytopenia	11.02	10.68	10	162480	5984	29406053
Tuberculosis	11.00	10.68	14	162476	7182	29404855
Anaphylactic shock	11.00	10.68	37	162453	13299	29398738
Hepatitis cholestatic	10.97	10.68	13	162477	6880	29405157
Wound haemorrhage	10.96	10.68	28	162462	1779	29410258
Hyperammonaemia	10.95	10.68	9	162481	5654	29406383
Antiphospholipid antibodies	10.90	10.68	4	162486	14	29412023
Uveitis	10.84	10.68	10	162480	5937	29406100
Respiratory depression	10.82	10.68	38	162452	13485	29398552
Cor pulmonale	10.78	10.68	16	162474	677	29411360
Tubulointerstitial nephritis	10.77	10.68	55	162435	17588	29394449
Sterile pyuria	10.73	10.68	5	162485	36	29412001
Skin haemorrhage	10.72	10.68	44	162446	3593	29408444
Disorientation	10.69	10.68	107	162383	29408	29382629
Hypogammaglobulinaemia	10.68	10.68	10	162480	5897	29406140

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
International normalised ratio increased	17353.25	10.15	8116	295803	71051	64123762
Haemorrhage	2203.87	10.15	2270	301649	77081	64117732
International normalised ratio abnormal	2088.92	10.15	812	303107	4176	64190637
Gastric haemorrhage	1968.96	10.15	1053	302866	12428	64182385
Drug interaction	1752.05	10.15	4669	299250	357414	63837399
International normalised ratio decreased	1662.68	10.15	777	303142	6701	64188112
Gastrointestinal haemorrhage	1465.09	10.15	2401	301518	129911	64064902
Anticoagulation drug level above therapeutic	1397.69	10.15	530	303389	2515	64192298
Haematoma	1135.63	10.15	1240	302679	45010	64149803
Calciphylaxis	1122.53	10.15	463	303456	2849	64191964
Subdural haematoma	1019.57	10.15	931	302988	27123	64167690
Melaena	914.14	10.15	1193	302726	52355	64142458
Drug ineffective	889.90	10.15	1632	302287	838615	63356198
Haematuria	883.27	10.15	1249	302670	59222	64135591
Epistaxis	840.73	10.15	1592	302327	96539	64098274
Pulmonary arterial hypertension	803.32	10.15	780	303139	24587	64170226
Haemorrhage intracranial	770.63	10.15	742	303177	23142	64171671
Labelled drug-drug interaction medication error	669.88	10.15	663	303256	21399	64173414
Fluid retention	640.38	10.15	1068	302851	58538	64136275
Anticoagulation drug level below therapeutic	629.82	10.15	236	303683	1076	64193737
Cerebral haemorrhage	619.21	10.15	967	302952	50123	64144690
Cardiac failure congestive	573.04	10.15	1628	302291	128952	64065861
Haemoglobin decreased	569.92	10.15	2116	301803	192947	64001866
Anaemia	549.87	10.15	3352	300567	375328	63819485
International normalised ratio fluctuation	541.05	10.15	269	303650	2692	64192121
Rectal haemorrhage	523.10	10.15	998	302921	60819	64133994
Off label use	515.38	10.15	1416	302503	631390	63563423
Prothrombin time prolonged	515.26	10.15	493	303426	15248	64179565
Dyspnoea	507.77	10.15	5389	298530	713285	63481528
Coagulopathy	439.05	10.15	641	303278	31279	64163534
Haemoptysis	434.99	10.15	808	303111	48240	64146573
Synovitis	422.72	10.15	9	303910	99081	64095732
Pulmonary hypertension	410.88	10.15	733	303186	42406	64152407
Febrile neutropenia	407.52	10.15	187	303732	187470	64007343
Abdominal wall haematoma	398.26	10.15	250	303669	4055	64190758
Cardiac failure	392.15	10.15	1443	302476	130930	64063883
Muscle haemorrhage	387.05	10.15	274	303645	5479	64189334
Right ventricular failure	368.75	10.15	480	303439	20991	64173822
Atrial fibrillation	368.38	10.15	1690	302229	169399	64025414
Infusion related reaction	366.34	10.15	158	303761	164309	64030504
Pain in jaw	350.91	10.15	663	303256	40092	64154721
Drug intolerance	350.46	10.15	227	303692	187765	64007048
Rheumatoid arthritis	323.49	10.15	186	303733	164108	64030705
Hypervolaemia	316.30	10.15	612	303307	37673	64157140
Catheter site erythema	314.83	10.15	226	303693	4623	64190190
Drug abuse	298.23	10.15	125	303794	132249	64062564
Drug hypersensitivity	297.18	10.15	412	303507	237403	63957410
Transfusion	294.67	10.15	393	303526	17601	64177212
Retroperitoneal haematoma	284.15	10.15	210	303709	4501	64190312
Upper gastrointestinal haemorrhage	283.64	10.15	557	303362	34663	64160150
Arthralgia	280.13	10.15	1104	302815	441156	63753657
Pemphigus	269.48	10.15	3	303916	60698	64134115
Ecchymosis	268.55	10.15	331	303588	13691	64181122
Joint swelling	267.21	10.15	375	303544	215007	63979806
Dyspnoea exertional	265.55	10.15	858	303061	72872	64121941
Faeces discoloured	256.36	10.15	446	303473	25283	64169530
Fall	254.41	10.15	3041	300878	413785	63781028
Therapeutic product effect decreased	253.35	10.15	113	303806	115238	64079575
Neutropenia	252.32	10.15	465	303454	239159	63955654
Subarachnoid haemorrhage	251.68	10.15	369	303550	18069	64176744
Alopecia	246.51	10.15	250	303669	165440	64029373
Subdural haemorrhage	241.02	10.15	200	303719	5103	64189710
Thrombosis	222.55	10.15	786	303133	69856	64124957
Pain	221.19	10.15	1614	302305	551897	63642916
Catheter site pain	221.15	10.15	177	303742	4285	64190528
Catheter management	219.26	10.15	157	303762	3198	64191615
Treatment failure	216.32	10.15	142	303777	116674	64078139
Coagulation time prolonged	212.13	10.15	130	303789	2016	64192797
Product use in unapproved indication	209.70	10.15	317	303602	176301	64018512
Device related infection	209.67	10.15	453	303466	30173	64164640
Retroperitoneal haemorrhage	205.61	10.15	176	303743	4692	64190121
Oedema peripheral	203.87	10.15	1690	302229	208627	63986186
Hypersensitivity	198.18	10.15	391	303528	196061	63998752
Hand deformity	194.97	10.15	31	303888	62740	64132073
Catheter site discharge	194.49	10.15	125	303794	2116	64192697
Completed suicide	193.39	10.15	487	303432	223927	63970886
Musculoskeletal stiffness	192.39	10.15	178	303741	123028	64071785
Pyrexia	192.23	10.15	1696	302223	556948	63637865
Stomatitis	191.35	10.15	142	303777	109463	64085350
Oedema	188.71	10.15	896	303023	91039	64103774
Haematemesis	183.95	10.15	563	303356	46436	64148377
Contraindicated product administered	181.49	10.15	145	303774	107684	64087129
Haematocrit decreased	180.70	10.15	618	303301	54037	64140776
Rash	179.69	10.15	1344	302575	457205	63737608
Heparin-induced thrombocytopenia	176.82	10.15	209	303710	8270	64186543
Lower gastrointestinal haemorrhage	173.20	10.15	267	303652	13672	64181141
Haemarthrosis	171.54	10.15	164	303755	5065	64189748
Arthropathy	171.50	10.15	190	303729	120777	64074036
Pericarditis	170.87	10.15	42	303877	62474	64132339
Glossodynia	170.08	10.15	47	303872	64649	64130164
Syncope	169.81	10.15	1298	302621	156337	64038476
Intra-abdominal haematoma	168.92	10.15	119	303800	2360	64192453
Catheter site pruritus	167.37	10.15	112	303807	2036	64192777
Intraventricular haemorrhage	165.00	10.15	145	303774	4008	64190805
Depression	164.77	10.15	389	303530	182902	64011911
Hepatic enzyme increased	161.29	10.15	226	303693	129717	64065096
Central venous catheterisation	158.20	10.15	119	303800	2622	64192191
Catheter site infection	154.38	10.15	161	303758	5532	64189281
Shock haemorrhagic	154.33	10.15	281	303638	16510	64178303
Intentional overdose	153.82	10.15	119	303800	89825	64104988
Therapeutic product effect incomplete	151.74	10.15	158	303761	103324	64091489
Device alarm issue	150.77	10.15	100	303819	1790	64193023
Catheter site haemorrhage	150.62	10.15	144	303775	4447	64190366
Hypotension	150.48	10.15	2576	301343	378398	63816415
Skin necrosis	150.11	10.15	254	303665	14075	64180738
Product use issue	143.64	10.15	313	303606	151402	64043411
Injection site pain	143.07	10.15	189	303730	111219	64083594
Mucosal inflammation	142.67	10.15	58	303861	62526	64132287
Leukopenia	142.43	10.15	160	303759	101082	64093731
Blood loss anaemia	138.62	10.15	241	303678	13651	64181162
Head injury	132.81	10.15	398	303521	32444	64162369
Malignant neoplasm progression	131.59	10.15	205	303714	112666	64082147
Infusion site pain	126.17	10.15	197	303722	10200	64184613
Thrombosis in device	126.16	10.15	137	303782	4934	64189879
Exposure during pregnancy	123.88	10.15	110	303809	77565	64117248
Systemic lupus erythematosus	123.67	10.15	110	303809	77502	64117311
Spinal epidural haematoma	119.62	10.15	74	303845	1168	64193645
Catheter placement	118.27	10.15	98	303821	2495	64192318
Sinusitis	117.78	10.15	327	303592	145601	64049212
Deep vein thrombosis	116.52	10.15	872	303047	104310	64090503
Pruritus	115.91	10.15	929	302990	311471	63883342
Urticaria	115.30	10.15	335	303584	146982	64047831
Occult blood positive	114.93	10.15	145	303774	6142	64188671
Duodenal ulcer perforation	114.81	10.15	14	303905	34611	64160202
Anaphylactic reaction	114.69	10.15	93	303826	68571	64126242
Catheter site swelling	112.82	10.15	79	303840	1551	64193262
Folliculitis	110.76	10.15	8	303911	30069	64164744
Dizziness	109.79	10.15	2727	301192	427436	63767377
Injection site erythema	109.65	10.15	103	303816	70697	64124116
Maternal exposure during pregnancy	109.06	10.15	177	303742	95707	64099106
Discomfort	108.19	10.15	133	303786	80745	64114068
Intestinal haematoma	107.59	10.15	37	303882	124	64194689
Injection site reaction	106.76	10.15	43	303876	46621	64148192
Activated partial thromboplastin time prolonged	103.37	10.15	203	303716	12628	64182185
Helicobacter infection	102.47	10.15	27	303892	38335	64156478
Suicidal ideation	101.65	10.15	98	303821	66444	64128369
Haematoma muscle	101.61	10.15	77	303842	1716	64193097
Contusion	101.45	10.15	899	303020	113066	64081747
Haemoperitoneum	101.32	10.15	108	303811	3807	64191006
Toxicity to various agents	100.10	10.15	1163	302756	362350	63832463
Hypertension	99.85	10.15	763	303156	258498	63936315
Sleep disorder due to general medical condition, insomnia type	99.65	10.15	6	303913	26264	64168549
Pancytopenia	99.44	10.15	344	303575	142965	64051848
Post procedural haemorrhage	99.34	10.15	196	303723	12235	64182578
Haemorrhage subcutaneous	98.48	10.15	112	303807	4249	64190564
Haemorrhagic stroke	98.46	10.15	172	303747	9779	64185034
Device leakage	98.05	10.15	155	303764	8111	64186702
Cardiac pacemaker insertion	96.87	10.15	119	303800	4904	64189909
Hospitalisation	96.40	10.15	646	303273	74561	64120252
General physical health deterioration	94.97	10.15	569	303350	203856	63990957
Cerebrovascular accident	94.93	10.15	1029	302890	136554	64058259
Complication associated with device	94.13	10.15	215	303704	14865	64179948
Anticoagulant-related nephropathy	93.92	10.15	25	303894	21	64194792
Psoriasis	92.69	10.15	121	303798	71582	64123231
Psoriatic arthropathy	92.50	10.15	44	303875	43237	64151576
Spontaneous haematoma	91.25	10.15	63	303856	1208	64193605
Wound	89.98	10.15	138	303781	76339	64118474
Cerebral mass effect	89.54	10.15	70	303849	1636	64193177
Gingival bleeding	87.48	10.15	207	303712	14647	64180166
Suicide attempt	86.59	10.15	125	303794	70882	64123931
Irritable bowel syndrome	86.20	10.15	34	303885	37335	64157478
Infusion site infection	85.47	10.15	66	303853	1514	64193299
Intentional product use issue	84.36	10.15	204	303715	95160	64099653
Lung transplant	83.58	10.15	100	303819	4008	64190805
Infection	83.04	10.15	520	303399	184360	64010453
Drug dependence	82.47	10.15	27	303892	33285	64161528
Extradural haematoma	82.28	10.15	81	303838	2595	64192218
Multiple sclerosis relapse	81.70	10.15	46	303873	41089	64153724
Presyncope	81.66	10.15	355	303564	34734	64160079
Injection site pruritus	81.54	10.15	38	303881	37788	64157025
Anxiety	81.04	10.15	590	303329	202059	63992754
Pulmonary alveolar haemorrhage	80.80	10.15	156	303763	9582	64185231
Paraesthesia	80.37	10.15	343	303576	134179	64060634
Muscle injury	79.99	10.15	14	303905	26423	64168390
Asthma	79.35	10.15	210	303709	95015	64099798
Atrial flutter	78.48	10.15	235	303684	19145	64175668
Catheter site inflammation	77.81	10.15	51	303868	894	64193919
Traumatic haematoma	77.60	10.15	68	303851	1872	64192941
Neutrophil count decreased	77.46	10.15	154	303765	77042	64117771
Seizure	77.25	10.15	465	303454	166427	64028386
Ear haemorrhage	74.39	10.15	66	303853	1848	64192965
Subcutaneous haematoma	74.20	10.15	74	303845	2409	64192404
Cerebellar haemorrhage	74.07	10.15	76	303843	2561	64192252
Blood cholesterol increased	73.87	10.15	76	303843	49990	64144823
Sleep disorder	72.91	10.15	105	303814	59604	64135209
Coagulation test abnormal	72.29	10.15	52	303867	1067	64193746
Hypocoagulable state	72.22	10.15	64	303855	1789	64193024
Infusion site erythema	72.21	10.15	122	303797	6751	64188062
Ventricular tachycardia	71.02	10.15	335	303584	33930	64160883
Osteoarthritis	71.00	10.15	118	303801	63218	64131595
Intra-abdominal haemorrhage	70.58	10.15	91	303828	3940	64190873
Cardiac failure chronic	70.38	10.15	141	303778	8900	64185913
Generalised tonic-clonic seizure	70.36	10.15	51	303868	39806	64155007
Cytokine release syndrome	70.10	10.15	8	303911	20821	64173992
Internal haemorrhage	70.06	10.15	128	303791	7539	64187274
Prothrombin time ratio increased	69.72	10.15	30	303889	208	64194605
Bradycardia	69.38	10.15	857	303062	117362	64077451
Acute myeloid leukaemia	68.44	10.15	22	303897	27441	64167372
Asthenia	68.04	10.15	2561	301358	425483	63769330
Choroidal haemorrhage	67.94	10.15	26	303893	127	64194686
C-reactive protein increased	67.73	10.15	225	303694	94684	64100129
Prothrombin time abnormal	67.53	10.15	45	303874	812	64194001
Device occlusion	67.11	10.15	146	303773	9767	64185046
Serotonin syndrome	67.11	10.15	52	303867	39230	64155583
Compartment syndrome	67.09	10.15	91	303828	4141	64190672
Inflammation	66.61	10.15	129	303790	65171	64129642
Injection site swelling	66.60	10.15	58	303861	41295	64153518
Catheter site rash	65.17	10.15	46	303873	915	64193898
Haematochezia	65.05	10.15	535	303384	65838	64128975
Palpitations	65.04	10.15	766	303153	103722	64091091
Conjunctival haemorrhage	64.95	10.15	98	303821	4923	64189890
COVID-19	64.45	10.15	131	303788	65009	64129804
Cardiac tamponade	64.36	10.15	128	303791	8036	64186777
Pericardial haemorrhage	64.16	10.15	88	303831	4048	64190765
Angioedema	64.04	10.15	121	303798	61700	64133113
Nasal congestion	64.01	10.15	491	303428	59167	64135646
Appendicolith	63.40	10.15	80	303839	3389	64191424
Loss of personal independence in daily activities	63.28	10.15	156	303763	72298	64122515
Cardiac disorder	63.06	10.15	465	303454	55351	64139462
Cardiac operation	62.88	10.15	88	303831	4126	64190687
White blood cell count decreased	62.86	10.15	460	303459	157377	64037436
Pulmonary endarterectomy	62.77	10.15	27	303892	187	64194626
Hypercoagulation	62.02	10.15	69	303850	2554	64192259
Food interaction	61.91	10.15	53	303866	1413	64193400
Cardioactive drug level increased	61.89	10.15	79	303840	3386	64191427
Chest pain	61.83	10.15	1502	302417	234478	63960335
Potentiating drug interaction	61.77	10.15	123	303796	7729	64187084
Haematoma evacuation	61.76	10.15	30	303889	284	64194529
Lower respiratory tract infection	61.71	10.15	233	303686	94381	64100432
Dystonia	61.64	10.15	8	303911	18857	64175956
Hypoaesthesia	61.55	10.15	393	303526	138715	64056098
Oxygen consumption increased	61.53	10.15	91	303828	4490	64190323
Wrong technique in product usage process	61.49	10.15	134	303785	64840	64129973
Myelosuppression	61.35	10.15	18	303901	23812	64171001
Cardiac failure acute	61.35	10.15	193	303726	16151	64178662
Blood pressure fluctuation	60.63	10.15	94	303825	51777	64143036
Blood pressure decreased	60.03	10.15	646	303273	85553	64109260
Pulmonary arterial pressure increased	60.00	10.15	85	303834	4031	64190782
Cytomegalovirus infection	58.91	10.15	53	303866	37146	64157667
Device expulsion	58.14	10.15	14	303905	21122	64173691
Cardiac valve replacement complication	58.03	10.15	26	303893	201	64194612
Pelvic haematoma	58.03	10.15	38	303881	665	64194148
International normalised ratio	58.01	10.15	21	303898	85	64194728
Death	58.01	10.15	2805	301114	479900	63714913
Impaired healing	57.82	10.15	124	303795	60349	64134464
Blood pressure increased	57.69	10.15	527	303392	172025	64022788
Accidental exposure to product	57.58	10.15	26	303893	26338	64168475
Device related sepsis	57.50	10.15	94	303825	5061	64189752
Medical device change	57.33	10.15	33	303886	453	64194360
Agitation	56.73	10.15	219	303700	88148	64106665
Pulmonary embolism	56.63	10.15	987	302932	145369	64049444
Ill-defined disorder	56.25	10.15	75	303844	43977	64150836
Arthritis	55.57	10.15	205	303714	83609	64111204
Gastrointestinal arteriovenous malformation	55.50	10.15	41	303878	878	64193935
Thrombocytopenia	55.48	10.15	732	303187	223069	63971744
Atrial thrombosis	55.35	10.15	70	303849	2972	64191841
Fibromyalgia	55.29	10.15	52	303867	35679	64159134
Insomnia	55.11	10.15	631	303288	197205	63997608
Dialysis	54.75	10.15	190	303729	16730	64178083
Colitis	54.71	10.15	122	303797	58552	64136261
Flushing	54.57	10.15	589	303330	78059	64116754
Catheterisation cardiac	54.55	10.15	89	303830	4784	64190029
Blister	54.37	10.15	197	303722	80770	64114043
Gout	53.98	10.15	222	303697	21191	64173622
Hepatocellular injury	53.81	10.15	81	303838	45154	64149659
Gastritis erosive	53.59	10.15	131	303788	9464	64185349
Mediastinal haematoma	53.52	10.15	24	303895	186	64194627
Oxygen saturation decreased	53.32	10.15	754	303165	106422	64088391
Anticoagulation drug level decreased	53.22	10.15	21	303898	113	64194700
Intentional self-injury	52.80	10.15	36	303883	29008	64165805
Adrenal haemorrhage	52.79	10.15	33	303886	531	64194282
Psychotic disorder	52.72	10.15	51	303868	34527	64160286
Cardiogenic shock	52.56	10.15	296	303623	32131	64162682
Hyperkalaemia	52.56	10.15	717	303202	100412	64094401
Cerebral haematoma	52.31	10.15	109	303810	7076	64187737
Transplant evaluation	51.39	10.15	49	303870	1508	64193305
Disturbance in attention	51.37	10.15	71	303848	41003	64153810
Red blood cell sedimentation rate increased	51.29	10.15	43	303876	31192	64163621
Haemothorax	50.94	10.15	86	303833	4756	64190057
Protein C decreased	50.83	10.15	17	303902	51	64194762
Vascular pseudoaneurysm	50.78	10.15	68	303851	3056	64191757
Hyphaema	50.67	10.15	34	303885	621	64194192
Cardioversion	50.56	10.15	53	303866	1832	64192981
Scrotal haematoma	50.49	10.15	18	303901	69	64194744
Intentional product misuse	50.48	10.15	173	303746	72122	64122691
Aggression	50.11	10.15	88	303831	46144	64148669
Mesenteric haematoma	50.02	10.15	14	303905	17	64194796
Gangrene	49.59	10.15	108	303811	7230	64187583
Foot deformity	49.37	10.15	9	303910	16495	64178318
Neoplasm progression	49.07	10.15	73	303846	40891	64153922
Hepatotoxicity	49.06	10.15	70	303849	39892	64154921
Herpes zoster	47.84	10.15	201	303718	78986	64115827
Haemophagocytic lymphohistiocytosis	47.78	10.15	12	303907	17597	64177216
Rheumatoid nodule	47.65	10.15	3	303916	12648	64182165
Sedation	47.64	10.15	76	303843	41386	64153427
Cognitive disorder	47.02	10.15	120	303799	54967	64139846
Bone marrow failure	46.95	10.15	97	303822	47855	64146958
Gastrointestinal disorder	46.91	10.15	240	303679	89469	64105344
Subarachnoid haematoma	46.53	10.15	18	303901	91	64194722
Lymphocyte count decreased	46.38	10.15	75	303844	40624	64154189
Lymphopenia	46.38	10.15	32	303887	25625	64169188
Spinal subdural haematoma	46.34	10.15	22	303897	197	64194616
Brain herniation	46.27	10.15	98	303821	6435	64188378
Tongue haematoma	46.15	10.15	22	303897	199	64194614
Venous pressure jugular increased	46.02	10.15	42	303877	1221	64193592
Pulmonary thrombosis	45.90	10.15	131	303788	10387	64184426
Diverticulum intestinal haemorrhagic	45.44	10.15	66	303853	3203	64191610
Atrial tachycardia	45.38	10.15	69	303850	3490	64191323
Arteriovenous malformation	45.32	10.15	46	303873	1530	64193283
Gastric ulcer haemorrhage	45.29	10.15	111	303808	8032	64186781
Oral herpes	45.11	10.15	24	303895	22128	64172685
Congestive hepatopathy	45.07	10.15	73	303846	3900	64190913
Mouth haemorrhage	44.52	10.15	124	303795	9695	64185118
Diabetic ketoacidosis	44.37	10.15	45	303874	29800	64165013
Therapy change	43.83	10.15	95	303824	6339	64188474
Tremor	43.56	10.15	467	303452	147763	64047050
Type 2 diabetes mellitus	43.36	10.15	58	303861	33962	64160851
Abdominal discomfort	43.12	10.15	602	303317	181720	64013093
Bronchopulmonary aspergillosis	42.98	10.15	18	303901	19067	64175746
Transient ischaemic attack	42.68	10.15	355	303564	43827	64150986
Pulmonary oedema	42.61	10.15	562	303357	78112	64116701
Traumatic intracranial haemorrhage	42.52	10.15	37	303882	1009	64193804
Eye haemorrhage	42.36	10.15	110	303809	8250	64186563
Coagulation time shortened	42.34	10.15	25	303894	361	64194452
Spinal cord haematoma	42.00	10.15	23	303896	285	64194528
Basal cell carcinoma	41.98	10.15	50	303869	30788	64164025
Pneumocystis jirovecii pneumonia	41.85	10.15	41	303878	27593	64167220
Antiphospholipid syndrome	41.57	10.15	44	303875	1538	64193275
Neuroleptic malignant syndrome	41.55	10.15	34	303885	24962	64169851
Febrile bone marrow aplasia	41.42	10.15	3	303916	11252	64183561
Medical device site thrombosis	41.01	10.15	13	303906	31	64194782
Duodenal ulcer	40.70	10.15	155	303764	14280	64180533
Heart valve replacement	40.67	10.15	31	303888	697	64194116
Catheter removal	40.50	10.15	28	303891	538	64194275
Vitamin K deficiency	40.35	10.15	30	303889	649	64194164
Therapeutic product effect increased	40.16	10.15	40	303879	1300	64193513
Infusion site haemorrhage	40.12	10.15	52	303867	2263	64192550
Neurotoxicity	39.97	10.15	42	303877	27362	64167451
Pulmonary haemorrhage	39.66	10.15	144	303775	12965	64181848
Device connection issue	39.63	10.15	33	303886	846	64193967
Lymphadenopathy	39.61	10.15	102	303817	46584	64148229
Penile necrosis	39.37	10.15	13	303906	37	64194776
Duodenal ulcer haemorrhage	39.28	10.15	90	303829	6235	64188578
Cellulitis	39.28	10.15	640	303279	93017	64101796
Foetal warfarin syndrome	39.26	10.15	9	303910	0	64194813
Neuropathy peripheral	39.24	10.15	359	303560	117166	64077647
Cardiac ablation	39.15	10.15	45	303874	1727	64193086
Rash maculo-papular	38.94	10.15	104	303815	46922	64147891
Abdominal distension	38.79	10.15	652	303267	95342	64099471
Acute kidney injury	38.75	10.15	2533	301386	446707	63748106
Mallory-Weiss syndrome	38.63	10.15	54	303865	2529	64192284
Restlessness	38.52	10.15	81	303838	39704	64155109
Pancreatitis acute	38.42	10.15	91	303828	42764	64152049
Therapeutic response decreased	38.42	10.15	122	303797	52066	64142747
Tendonitis	38.41	10.15	24	303895	20258	64174555
Osteoporosis	38.01	10.15	89	303830	41991	64152822
Sinus tachycardia	37.93	10.15	58	303861	32130	64162683
Palmar-plantar erythrodysaesthesia syndrome	37.89	10.15	48	303871	28771	64166042
Drug resistance	37.87	10.15	67	303852	35035	64159778
Blue toe syndrome	37.66	10.15	27	303892	551	64194262
Dizziness postural	37.38	10.15	116	303803	9636	64185177
Chest wall haematoma	37.34	10.15	23	303896	360	64194453
Renal haemorrhage	37.19	10.15	46	303873	1909	64192904
Muscle spasticity	37.09	10.15	16	303903	16653	64178160
Intracardiac thrombus	36.95	10.15	65	303854	3716	64191097
Hypoprothrombinaemia	36.65	10.15	29	303890	690	64194123
Aphthous ulcer	36.59	10.15	8	303911	12898	64181915
Graft versus host disease	36.36	10.15	10	303909	13803	64181010
Infective pulmonary exacerbation of cystic fibrosis	36.23	10.15	6	303913	11790	64183023
Brain natriuretic peptide increased	36.21	10.15	98	303821	7535	64187278
Aspergillus infection	36.01	10.15	16	303903	16363	64178450
Anticoagulation drug level increased	35.94	10.15	28	303891	651	64194162
Hypokalaemia	35.83	10.15	384	303535	121519	64073294
Embolic stroke	35.76	10.15	90	303829	6621	64188192
Hyperhidrosis	35.72	10.15	396	303523	124524	64070289
Anticoagulation drug level abnormal	35.68	10.15	11	303908	23	64194790
Pancreatitis	35.57	10.15	152	303767	59455	64135358
Dry eye	35.45	10.15	51	303868	28968	64165845
Hypercholesterolaemia	35.43	10.15	14	303905	15359	64179454
Drug monitoring procedure not performed	35.29	10.15	30	303889	792	64194021
Aortic valve replacement	35.23	10.15	35	303884	1134	64193679
Emotional distress	35.20	10.15	73	303846	35965	64158848
Product administration error	35.14	10.15	237	303682	27406	64167407
Immunodeficiency	35.06	10.15	16	303903	16108	64178705
Diverticulum	35.00	10.15	139	303780	13059	64181754
Aplastic anaemia	34.96	10.15	11	303908	13909	64180904
Prosthetic cardiac valve thrombosis	34.94	10.15	12	303907	40	64194773
Tracheal calcification	34.90	10.15	8	303911	0	64194813
Dermatitis contact	34.44	10.15	107	303812	8893	64185920
Catheter site related reaction	34.32	10.15	32	303887	957	64193856
Dry mouth	34.28	10.15	157	303762	60261	64134552
Emergency care	34.12	10.15	31	303888	896	64193917
Vascular device infection	34.11	10.15	84	303835	6096	64188717
Hepatitis	33.95	10.15	106	303813	45476	64149337
Thalamus haemorrhage	33.91	10.15	40	303879	1579	64193234
Catheter site discolouration	33.81	10.15	15	303904	113	64194700
Posterior reversible encephalopathy syndrome	33.65	10.15	35	303884	22911	64171902
Hydrocephalus	33.57	10.15	95	303824	7496	64187317
Vascular pseudoaneurysm ruptured	33.45	10.15	16	303903	146	64194667
Concomitant disease progression	32.99	10.15	57	303862	3212	64191601
Immune reconstitution inflammatory syndrome	32.88	10.15	9	303910	12461	64182352
Haemorrhagic diathesis	32.64	10.15	77	303842	5437	64189376
Prothrombin consumption time prolonged	32.41	10.15	11	303908	35	64194778
Cholestasis	32.26	10.15	106	303813	44766	64150047
Conjunctivitis	32.23	10.15	29	303890	20325	64174488
Atheroembolism	32.19	10.15	18	303901	233	64194580
Bradyarrhythmia	32.16	10.15	61	303858	3697	64191116
Anaphylactic shock	31.72	10.15	59	303860	30269	64164544
Catheter site irritation	31.70	10.15	24	303895	534	64194279
Mouth ulceration	31.45	10.15	66	303853	32378	64162435
Device infusion issue	31.27	10.15	40	303879	1718	64193095
Bursitis	31.25	10.15	33	303886	21452	64173361
Hypophagia	30.55	10.15	303	303616	39284	64155529
Acute generalised exanthematous pustulosis	30.49	10.15	14	303905	14044	64180769
Aortic stenosis	30.47	10.15	82	303837	6283	64188530
Abnormal behaviour	30.45	10.15	71	303848	33551	64161262
Gastric ulcer	30.31	10.15	245	303674	29989	64164824
Mineral supplementation	30.31	10.15	27	303892	760	64194053
Endarterectomy	30.27	10.15	19	303900	308	64194505
Laryngeal haematoma	30.17	10.15	15	303904	150	64194663
Cytomegalovirus viraemia	30.12	10.15	7	303912	10821	64183992
Drug reaction with eosinophilia and systemic symptoms	30.10	10.15	142	303777	54075	64140738
Wheezing	30.09	10.15	239	303680	80340	64114473
Catheter culture positive	30.03	10.15	16	303903	187	64194626
Sinus node dysfunction	29.76	10.15	85	303834	6743	64188070
Fatigue	29.52	10.15	3084	300835	745646	63449167
Chills	29.40	10.15	462	303457	136802	64058011
Atrial septal defect repair	29.31	10.15	20	303899	376	64194437
Pregnancy	29.30	10.15	33	303886	20832	64173981
Encephalopathy	29.27	10.15	160	303759	58659	64136154
Mitral valve replacement	29.19	10.15	19	303900	329	64194484
Large intestinal haemorrhage	29.16	10.15	47	303872	2500	64192313
Irritability	29.13	10.15	83	303836	36663	64158150
Pneumonitis	29.10	10.15	130	303789	50235	64144578
Crying	29.06	10.15	31	303888	20059	64174754
Orthopnoea	29.06	10.15	102	303817	9032	64185781
Central venous catheter removal	28.72	10.15	20	303899	389	64194424
Colonic haematoma	28.67	10.15	12	303907	77	64194736
Osteopenia	28.60	10.15	19	303900	15521	64179292
Oxygen therapy	28.59	10.15	44	303875	2249	64192564
Myocarditis	28.55	10.15	23	303896	17020	64177793
Infusion site warmth	28.50	10.15	30	303889	1042	64193771
Protein S deficiency	28.42	10.15	14	303905	137	64194676
Drug withdrawal syndrome	28.40	10.15	66	303853	31225	64163588
Tuberculosis	28.25	10.15	13	303906	13025	64181788
Diffuse large B-cell lymphoma	28.23	10.15	7	303912	10354	64184459
Inappropriate schedule of product administration	28.22	10.15	288	303631	91998	64102815
Dizziness exertional	28.22	10.15	21	303898	455	64194358
Withdrawal syndrome	28	10.15	42	303877	23450	64171363
Drug ineffective for unapproved indication	27.99	10.15	66	303853	31067	64163746
Hypertriglyceridaemia	27.88	10.15	9	303910	11196	64183617
Diabetes mellitus	27.77	10.15	191	303728	66283	64128530
Haemorrhoidal haemorrhage	27.70	10.15	74	303845	5645	64189168
Drug-induced liver injury	27.51	10.15	123	303796	47520	64147293
Extrapyramidal disorder	27.37	10.15	31	303888	19521	64175292
Osteonecrosis of jaw	27.33	10.15	96	303823	39729	64155084
Periorbital haematoma	27.32	10.15	27	303892	869	64193944
Myxoedema coma	27.32	10.15	24	303895	663	64194150
Skin weeping	27.25	10.15	23	303896	601	64194212
Vascular calcification	27.04	10.15	28	303891	954	64193859
Device interaction	26.99	10.15	24	303895	674	64194139
Joint stiffness	26.91	10.15	65	303854	30339	64164474
Blood urine present	26.86	10.15	163	303756	18177	64176636
Injection site warmth	26.81	10.15	15	303904	13447	64181366
Chest tube insertion	26.77	10.15	13	303906	123	64194690
Night sweats	26.72	10.15	84	303835	35962	64158851
Injection site rash	26.68	10.15	21	303898	15721	64179092
Gravitational oedema	26.58	10.15	36	303883	1636	64193177
Infusion site irritation	26.53	10.15	20	303899	442	64194371
Breast necrosis	26.49	10.15	11	303908	69	64194744
Neuralgia	26.46	10.15	52	303867	26132	64168681
Neutropenic sepsis	26.41	10.15	43	303876	23229	64171584
Walking distance test abnormal	26.41	10.15	24	303895	694	64194119
Infected skin ulcer	26.28	10.15	49	303870	2931	64191882
Mobility decreased	26.20	10.15	268	303651	85572	64109241
Breast haematoma	26.17	10.15	14	303905	165	64194648
Obstructive airways disorder	26.16	10.15	43	303876	23142	64171671
Transplant rejection	26.14	10.15	26	303893	17375	64177438
Pharyngeal haematoma	26.12	10.15	12	303907	99	64194714
Ascites	26.10	10.15	424	303495	61577	64133236
Sciatic nerve palsy	26.10	10.15	11	303908	72	64194741
Depressed mood	26.08	10.15	102	303817	40910	64153903
Schizophrenia	26.02	10.15	10	303909	11158	64183655
Alanine aminotransferase increased	25.87	10.15	480	303439	138551	64056262
Calcium deficiency	25.84	10.15	24	303895	714	64194099
Thrombectomy	25.84	10.15	16	303903	253	64194560
Transaminases increased	25.82	10.15	115	303804	44479	64150334
Hepatic failure	25.78	10.15	154	303765	55240	64139573
Ankylosing spondylitis	25.71	10.15	4	303915	8230	64186583
Drug eruption	25.54	10.15	86	303833	36050	64158763
Infusion site cellulitis	25.46	10.15	16	303903	260	64194553
Neutrophil count increased	25.43	10.15	50	303869	25124	64169689
Illness	25.40	10.15	40	303879	21898	64172915
Poisoning deliberate	25.38	10.15	16	303903	13442	64181371
Muscle spasms	25.28	10.15	490	303429	140533	64054280
Polyneuropathy	25.27	10.15	34	303885	19860	64174953
Injection site discharge	25.20	10.15	19	303900	420	64194393
Femoral nerve palsy	25.17	10.15	10	303909	55	64194758
Acne	24.95	10.15	44	303875	23037	64171776
Infusion site oedema	24.94	10.15	22	303897	611	64194202
Impaired work ability	24.93	10.15	21	303898	15198	64179615
Tumour lysis syndrome	24.92	10.15	33	303886	19407	64175406
Product storage error	24.89	10.15	16	303903	13302	64181511
Hypercalcaemia	24.88	10.15	71	303848	31345	64163468
Protein S decreased	24.78	10.15	11	303908	83	64194730
Migraine	24.77	10.15	183	303736	62494	64132319
Epstein-Barr virus infection	24.75	10.15	14	303905	12474	64182339
Acute respiratory failure	24.70	10.15	351	303568	49583	64145230
Device breakage	24.67	10.15	94	303825	8661	64186152
Ovarian haemorrhage	24.58	10.15	16	303903	277	64194536
Hyperglycaemia	24.58	10.15	177	303742	60791	64134022
Ear pain	24.48	10.15	51	303868	25085	64169728
Influenza like illness	24.46	10.15	180	303739	61522	64133291
Rash erythematous	24.36	10.15	132	303787	48501	64146312
Hyperbilirubinaemia	24.23	10.15	39	303880	21166	64173647
Gastric antral vascular ectasia	24.00	10.15	24	303895	784	64194029
Torsade de pointes	23.98	10.15	152	303767	17211	64177602
Substance abuse	23.95	10.15	7	303912	9285	64185528
Spinal cord haemorrhage	23.94	10.15	20	303899	515	64194298
Adenovirus infection	23.89	10.15	3	303916	7252	64187561
Hepatic steatosis	23.88	10.15	71	303848	30936	64163877
Purpura	23.83	10.15	151	303768	17095	64177718
Dyskinesia	23.77	10.15	100	303819	39288	64155525
Blood viscosity abnormal	23.76	10.15	6	303913	3	64194810
Status epilepticus	23.68	10.15	41	303878	21622	64173191
Encephalitis	23.64	10.15	15	303904	12556	64182257
Nightmare	23.63	10.15	39	303880	20954	64173859
Hallucination, auditory	23.56	10.15	27	303892	16912	64177901
Renal vascular thrombosis	23.53	10.15	10	303909	67	64194746
Cerebral infarction	23.40	10.15	296	303623	40748	64154065
Condition aggravated	23.39	10.15	1477	302442	370949	63823864
Lethargy	23.37	10.15	476	303443	72118	64122695
Parkinsonism	23.34	10.15	20	303899	14353	64180460
Catheter site warmth	23.33	10.15	15	303904	254	64194559
Anovulatory cycle	23.22	10.15	11	303908	98	64194715
Haemorrhagic cholecystitis	23.16	10.15	10	303909	70	64194743
Ventricular hyperkinesia	23.13	10.15	15	303904	258	64194555
Blood glucose increased	23.11	10.15	324	303595	97749	64097064
Cataract	23.08	10.15	144	303775	51118	64143695
Catheter site vesicles	23.07	10.15	16	303903	309	64194504
Mood swings	23.06	10.15	29	303890	17439	64177374
Arteriovenous fistula site haemorrhage	22.99	10.15	16	303903	311	64194502
Epilepsy	22.89	10.15	81	303838	33450	64161363
Dilatation ventricular	22.86	10.15	54	303865	3816	64190997
Cardiac pacemaker replacement	22.85	10.15	17	303902	368	64194445
Apallic syndrome	22.77	10.15	24	303895	835	64193978
Blood viscosity decreased	22.69	10.15	10	303909	74	64194739
Petechiae	22.67	10.15	158	303761	18468	64176345
Renal haematoma	22.47	10.15	22	303897	700	64194113
Device difficult to use	22.46	10.15	9	303910	9789	64185024
Haemobilia	22.39	10.15	17	303902	380	64194433
Pericardial effusion	22.34	10.15	283	303636	38971	64155842
Erythema	22.31	10.15	691	303228	186379	64008434
Heart valve operation	22.30	10.15	13	303906	183	64194630
Blood culture negative	22.30	10.15	13	303906	183	64194630
Hepatic cytolysis	22.26	10.15	20	303899	14029	64180784
Pathogen resistance	22.20	10.15	16	303903	12527	64182286
Ventricular fibrillation	22.13	10.15	190	303729	23670	64171143
Small intestinal haemorrhage	22.12	10.15	53	303866	3780	64191033
Cerebellar haematoma	22.10	10.15	20	303899	575	64194238
Incision site haemorrhage	22.09	10.15	25	303894	943	64193870
Embolism	22.07	10.15	115	303804	12120	64182693
Abortion spontaneous	22.05	10.15	54	303865	25089	64169724
Myoclonus	21.99	10.15	54	303865	25064	64169749
Anger	21.99	10.15	25	303894	15716	64179097
Hypovolaemic shock	21.73	10.15	101	303818	10165	64184648
Swelling	21.57	10.15	582	303337	159636	64035177
Iris haemorrhage	21.57	10.15	6	303913	7	64194806
Transplant dysfunction	21.55	10.15	3	303916	6705	64188108
Heart rate increased	21.44	10.15	613	303306	98062	64096751
Heart sounds abnormal	21.43	10.15	27	303892	1142	64193671
Candida infection	21.38	10.15	76	303843	31343	64163470
Back pain	21.37	10.15	962	302957	249209	63945604
Cor pulmonale	21.35	10.15	36	303883	1989	64192824
Swollen joint count increased	21.33	10.15	5	303914	7684	64187129
Psychomotor hyperactivity	21.24	10.15	22	303897	14429	64180384
Heart rate irregular	21.24	10.15	210	303709	27203	64167610
Urinary bladder rupture	21.21	10.15	10	303909	88	64194725
Nephropathy	21.18	10.15	87	303832	8299	64186514
Metastases to bone	21.16	10.15	40	303879	20395	64174418
Cardiac flutter	21.10	10.15	55	303864	4134	64190679
Haemorrhagic infarction	21.05	10.15	21	303898	684	64194129
Cardiac valve disease	21.04	10.15	63	303856	5132	64189681
Exostosis	21.03	10.15	14	303905	11424	64183389
Tongue haemorrhage	20.92	10.15	23	303896	840	64193973
Prescribed overdose	20.87	10.15	40	303879	20291	64174522
Vomiting	20.87	10.15	2276	301643	548841	63645972
Peripheral sensory neuropathy	20.82	10.15	14	303905	11364	64183449
Haemorrhagic ovarian cyst	20.80	10.15	18	303901	487	64194326
Haemorrhagic arteriovenous malformation	20.75	10.15	19	303900	555	64194258
Mental status changes	20.68	10.15	404	303515	60758	64134055
Multiple-drug resistance	20.67	10.15	3	303916	6499	64188314
Ulcer haemorrhage	20.64	10.15	57	303862	4435	64190378
Thrombotic microangiopathy	20.61	10.15	29	303890	16626	64178187
Fat embolism	20.57	10.15	16	303903	371	64194442
Angioplasty	20.54	10.15	32	303887	1653	64193160
Cholecystitis chronic	20.53	10.15	9	303910	9278	64185535
Intraocular haematoma	20.46	10.15	7	303912	23	64194790
Right ventricular dysfunction	20.41	10.15	37	303882	2166	64192647
Liver function test increased	20.36	10.15	76	303843	30894	64163919
Right atrial enlargement	20.35	10.15	15	303904	320	64194493
Blood pressure systolic decreased	20.34	10.15	89	303830	8731	64186082
Arteriovenous graft site haemorrhage	20.34	10.15	6	303913	10	64194803
Jugular vein distension	20.31	10.15	28	303891	1294	64193519
N-terminal prohormone brain natriuretic peptide increased	20.31	10.15	49	303870	3510	64191303
Left ventricular failure	20.23	10.15	86	303833	8331	64186482
Breast cancer	20.17	10.15	70	303849	29078	64165735
Carpal tunnel syndrome	20.15	10.15	27	303892	15801	64179012
Injection site urticaria	20.13	10.15	14	303905	11167	64183646
Urinary bladder haemorrhage	20.07	10.15	38	303881	2300	64192513
Aspiration pleural cavity	19.99	10.15	29	303890	1406	64193407
Poisoning	19.98	10.15	46	303873	21833	64172980
Pericarditis uraemic	19.98	10.15	6	303913	11	64194802
Acute hepatic failure	19.96	10.15	60	303859	26052	64168761
Paracentesis	19.85	10.15	27	303892	1232	64193581
Tumour haemorrhage	19.84	10.15	48	303871	3445	64191368
Hypoxia	19.82	10.15	550	303369	87599	64107214
Ubiquinone decreased	19.81	10.15	7	303912	26	64194787
Obesity	19.79	10.15	42	303877	20520	64174293
Gait disturbance	19.78	10.15	639	303280	171516	64023297
Subdural haematoma evacuation	19.70	10.15	8	303911	47	64194766
Disability	19.69	10.15	17	303902	12155	64182658
Cardiotoxicity	19.68	10.15	12	303907	10262	64184551
Multiple sclerosis	19.68	10.15	37	303882	18904	64175909
Disease recurrence	19.64	10.15	79	303840	31431	64163382
Thyroid haemorrhage	19.62	10.15	9	303910	74	64194739
Ovarian rupture	19.60	10.15	7	303912	27	64194786
Oral mucosa haematoma	19.56	10.15	8	303911	48	64194765
Factor V inhibition	19.50	10.15	15	303904	342	64194471
Blood blister	19.50	10.15	40	303879	2568	64192245
Oral candidiasis	19.47	10.15	51	303868	23161	64171652
Throat tightness	19.34	10.15	51	303868	23109	64171704
Therapeutic response shortened	19.31	10.15	12	303907	10158	64184655
Blood potassium increased	19.15	10.15	197	303722	25783	64169030
Injury	19.13	10.15	170	303749	55822	64138991
Implant site haematoma	19.11	10.15	11	303908	151	64194662
Uveitis	19.07	10.15	19	303900	12689	64182124
Agranulocytosis	19.02	10.15	104	303815	38125	64156688
Panniculitis	19.01	10.15	9	303910	8870	64185943
Xanthopsia	18.98	10.15	14	303905	299	64194514
Muscle twitching	18.96	10.15	38	303881	18960	64175853
Haemorrhagic cerebral infarction	18.95	10.15	27	303892	1287	64193526
Catheter site dermatitis	18.92	10.15	9	303910	81	64194732
Lacrimal haemorrhage	18.84	10.15	7	303912	31	64194782
Intervertebral disc protrusion	18.80	10.15	42	303877	20149	64174664
Chordae tendinae rupture	18.77	10.15	8	303911	54	64194759
Cardiac ventricular thrombosis	18.77	10.15	28	303891	1392	64193421
Akathisia	18.71	10.15	16	303903	11494	64183319
Exercise tolerance decreased	18.70	10.15	79	303840	7631	64187182
Burning sensation	18.68	10.15	147	303772	49517	64145296
Coagulation factor deficiency	18.64	10.15	9	303910	84	64194729
Progressive multifocal leukoencephalopathy	18.60	10.15	36	303883	18196	64176617
Iron deficiency anaemia	18.60	10.15	171	303748	21718	64173095
Adrenal insufficiency	18.41	10.15	50	303869	22437	64172376
Metastases to lymph nodes	18.41	10.15	9	303910	8708	64186105
Hypogammaglobulinaemia	18.41	10.15	13	303906	10286	64184527
Mitral valve repair	18.37	10.15	12	303907	209	64194604
Coeliac disease	18.36	10.15	6	303913	7406	64187407
Ovarian cyst	18.30	10.15	15	303904	11003	64183810
Haemorrhagic ascites	18.27	10.15	13	303906	262	64194551
Hepatic haematoma	18.25	10.15	21	303898	807	64194006
Sleep disorder due to a general medical condition	18.17	10.15	8	303911	8226	64186587
Injection site bruising	18.07	10.15	99	303820	36274	64158539
Hyperthyroidism	18.05	10.15	147	303772	18032	64176781
Prothrombin level abnormal	18.04	10.15	11	303908	169	64194644
Delusion	18.01	10.15	36	303883	17978	64176835
Ketoacidosis	18.01	10.15	5	303914	6858	64187955
Dysphagia	17.98	10.15	375	303544	106437	64088376
Pneumonia	17.96	10.15	2949	300970	556627	63638186
Splenic rupture	17.74	10.15	35	303884	2184	64192629
Catheter site dryness	17.69	10.15	7	303912	38	64194775
Oral disorder	17.68	10.15	10	303909	8911	64185902
Blood pressure diastolic abnormal	17.68	10.15	18	303901	11899	64182914
Large intestine polyp	17.61	10.15	99	303820	10738	64184075
Prothrombin level increased	17.55	10.15	15	303904	399	64194414
Endocarditis	17.51	10.15	89	303830	9289	64185524
Swollen tongue	17.44	10.15	95	303824	34859	64159954
Vitamin K decreased	17.41	10.15	8	303911	66	64194747
Musculoskeletal pain	17.27	10.15	274	303645	81020	64113793
Infusion site discharge	17.26	10.15	17	303902	545	64194268
Cardiac output increased	17.23	10.15	11	303908	184	64194629
Labelled drug-disease interaction medication error	17.18	10.15	13	303906	289	64194524
Intervertebral disc degeneration	17.09	10.15	22	303897	13098	64181715
Hip arthroplasty	17.09	10.15	48	303871	21303	64173510
Livedo reticularis	17.07	10.15	47	303872	3650	64191163
Body temperature increased	17.03	10.15	102	303817	36564	64158249
Heart transplant	17.02	10.15	25	303894	1226	64193587
Therapy partial responder	16.96	10.15	14	303905	10234	64184579
Gastrointestinal erosion	16.93	10.15	22	303897	960	64193853
Upper airway obstruction	16.91	10.15	25	303894	1233	64193580
Tinnitus	16.90	10.15	93	303826	34040	64160773
Bone pain	16.89	10.15	143	303776	47429	64147384
Panic attack	16.85	10.15	47	303872	20906	64173907
Injection site mass	16.85	10.15	35	303884	17235	64177578
Respiratory arrest	16.76	10.15	164	303755	52821	64141992
Spinal osteoarthritis	16.74	10.15	26	303893	14315	64180498
Procedural haemorrhage	16.69	10.15	51	303868	4201	64190612
Pulmonary haematoma	16.69	10.15	9	303910	108	64194705
Visual impairment	16.65	10.15	247	303672	73830	64120983
Blood creatinine increased	16.64	10.15	791	303128	134991	64059822
Knee arthroplasty	16.63	10.15	68	303851	26931	64167882
Pulmonary calcification	16.58	10.15	14	303905	366	64194447
Pulmonary arterial pressure abnormal	16.47	10.15	18	303901	653	64194160
Prothrombin level decreased	16.44	10.15	27	303892	1459	64193354
Protein C deficiency	16.44	10.15	6	303913	25	64194788
Implantable defibrillator replacement	16.37	10.15	5	303914	10	64194803
Prescribed underdose	16.35	10.15	38	303881	17977	64176836
Infusion site abscess	16.34	10.15	11	303908	202	64194611
Cardiac failure high output	16.32	10.15	12	303907	255	64194558
Sickle cell anaemia	16.28	10.15	17	303902	585	64194228
Unevaluable event	16.23	10.15	331	303588	50158	64144655
Demyelination	16.12	10.15	6	303913	6828	64187985
Cardio-respiratory arrest	16.11	10.15	347	303572	98046	64096767
Cerebral artery embolism	16.10	10.15	28	303891	1586	64193227
Right ventricular diastolic collapse	16.09	10.15	8	303911	80	64194733
Medical device site haematoma	16.07	10.15	6	303913	27	64194786
Thoracic haemorrhage	16.06	10.15	11	303908	208	64194605
Glaucoma	16.06	10.15	33	303886	16315	64178498
Arrhythmia	16.01	10.15	344	303575	52600	64142213
Tongue disorder	16.01	10.15	20	303899	12060	64182753
Puncture site haematoma	15.99	10.15	10	303909	161	64194652
Eschar	15.96	10.15	23	303896	1108	64193705
Mitral valve thickening	15.93	10.15	14	303905	387	64194426
Sciatica	15.89	10.15	46	303873	20218	64174595
Aortic bruit	15.88	10.15	11	303908	212	64194601
Catheter site nodule	15.86	10.15	7	303912	52	64194761
Loss of consciousness	15.86	10.15	853	303066	147512	64047301
Catheter site oedema	15.84	10.15	8	303911	83	64194730
Mitral valve disease	15.79	10.15	37	303882	2601	64192212
Angina pectoris	15.79	10.15	136	303783	44945	64149868
Eyelid ptosis	15.78	10.15	13	303906	9512	64185301
Radiation proctitis	15.76	10.15	8	303911	84	64194729
Muscle rigidity	15.74	10.15	37	303882	17436	64177377
No adverse event	15.74	10.15	75	303844	28486	64166327
Blood urea increased	15.73	10.15	294	303625	43859	64150954
Craniotomy	15.72	10.15	13	303906	330	64194483
Metastases to lung	15.70	10.15	30	303889	15234	64179579
Hip fracture	15.69	10.15	196	303723	26903	64167910
Hepatic rupture	15.64	10.15	7	303912	54	64194759
Klebsiella infection	15.58	10.15	24	303895	13257	64181556
Metastases to liver	15.57	10.15	59	303860	23882	64170931
Ischaemic stroke	15.54	10.15	207	303712	28828	64165985
Hernia repair	15.54	10.15	29	303890	1736	64193077
Liver abscess	15.53	10.15	3	303916	5277	64189536
Herpes simplex	15.53	10.15	16	303903	10520	64184293
Headache	15.52	10.15	2777	301142	526690	63668123
Metastases to central nervous system	15.51	10.15	26	303893	13886	64180927
Ulnar nerve palsy	15.47	10.15	5	303914	13	64194800
Catheter site mass	15.42	10.15	7	303912	56	64194757
Food allergy	15.27	10.15	9	303910	7842	64186971
Wound haemorrhage	15.23	10.15	43	303876	3388	64191425
Granulocytopenia	15.23	10.15	16	303903	10424	64184389
Abdominal cavity drainage	15.21	10.15	18	303901	713	64194100
Depressed level of consciousness	15.19	10.15	281	303638	81155	64113658
Arteriovenous fistula	15.16	10.15	20	303899	886	64193927
Drug tolerance decreased	15.13	10.15	7	303912	6991	64187822
Device physical property issue	15.11	10.15	32	303887	2101	64192712
Adverse drug reaction	15.11	10.15	139	303780	45325	64149488
Skin exfoliation	15.02	10.15	137	303782	44748	64150065
Drug specific antibody present	15.01	10.15	3	303916	5151	64189662
Infusion site pruritus	15.00	10.15	36	303883	2570	64192243
Incision site haematoma	15.00	10.15	9	303910	134	64194679
Hypochromasia	14.99	10.15	17	303902	643	64194170
Aplasia	14.96	10.15	7	303912	6946	64187867
Cardioactive drug level below therapeutic	14.95	10.15	5	303914	15	64194798
Odynophagia	14.95	10.15	14	303905	9627	64185186
Diabetes mellitus inadequate control	14.89	10.15	51	303868	21270	64173543
Tubulointerstitial nephritis	14.88	10.15	85	303834	30824	64163989
Right ventricular enlargement	14.85	10.15	15	303904	496	64194317
Pneumonia aspiration	14.81	10.15	375	303544	58896	64135917
Peritonitis	14.81	10.15	64	303855	24959	64169854
Enterocolitis	14.80	10.15	21	303898	11997	64182816
Respiratory failure	14.79	10.15	914	303005	160269	64034544
Blood pressure systolic abnormal	14.77	10.15	15	303904	9927	64184886
Synovial cyst	14.76	10.15	9	303910	7698	64187115
Appendicitis	14.73	10.15	112	303807	13457	64181356
Aneurysm	14.70	10.15	39	303880	2963	64191850
Coma scale normal	14.70	10.15	4	303915	4	64194809
Scleroderma	14.64	10.15	53	303866	4765	64190048
Post transplant lymphoproliferative disorder	14.64	10.15	14	303905	9530	64185283
Emergency care examination	14.62	10.15	7	303912	64	64194749
Catheter site erosion	14.62	10.15	7	303912	64	64194749
Post procedural haematoma	14.60	10.15	33	303886	2265	64192548
Hyponatraemic syndrome	14.59	10.15	18	303901	745	64194068
Left atrial enlargement	14.58	10.15	21	303898	1011	64193802
Proteinuria	14.58	10.15	74	303845	27649	64167164
Upper respiratory tract infection	14.58	10.15	248	303671	72537	64122276
Liver injury	14.58	10.15	82	303837	29850	64164963
IgA nephropathy	14.47	10.15	25	303894	1409	64193404
Dermatitis allergic	14.42	10.15	31	303888	15078	64179735
Lip haemorrhage	14.41	10.15	22	303897	1117	64193696
Ovarian cyst ruptured	14.39	10.15	19	303900	842	64193971
Nocturnal dyspnoea	14.34	10.15	24	303895	1318	64193495
Venous haemorrhage	14.15	10.15	11	303908	255	64194558
Mitral valve stenosis	14.09	10.15	21	303898	1043	64193770
Implantable defibrillator insertion	14.07	10.15	18	303901	773	64194040
Hyperlipidaemia	14.07	10.15	58	303861	22918	64171895
Malaise	14.04	10.15	2100	301819	394147	63800666
Cytomegalovirus chorioretinitis	14.02	10.15	3	303916	4909	64189904
N-telopeptide urine increased	14.02	10.15	6	303913	41	64194772
Hernia hiatus repair	14.02	10.15	6	303913	41	64194772
Application site irritation	14.01	10.15	26	303893	1550	64193263
Neutrophilia	14.01	10.15	7	303912	6687	64188126
Chronic respiratory failure	13.94	10.15	35	303884	2571	64192242
Polyomavirus-associated nephropathy	13.92	10.15	3	303916	4885	64189928
Herpes virus infection	13.88	10.15	6	303913	6238	64188575
Pre-eclampsia	13.83	10.15	6	303913	6225	64188588
Pleural effusion	13.80	10.15	729	303190	125830	64068983
Cardiac output decreased	13.77	10.15	27	303892	1677	64193136
Extrasystoles	13.72	10.15	65	303854	6593	64188220
Encephalomalacia	13.70	10.15	21	303898	1070	64193743
Mental disorder	13.68	10.15	71	303848	26374	64168439
Balloon atrial septostomy	13.64	10.15	8	303911	114	64194699
Nasopharyngitis	13.64	10.15	770	303149	195303	63999510
Haemorrhage urinary tract	13.62	10.15	31	303888	2138	64192675
Hepatitis B	13.55	10.15	10	303909	7735	64187078
Haematoma infection	13.52	10.15	23	303896	1280	64193533
Mania	13.49	10.15	36	303883	16250	64178563
Libido decreased	13.49	10.15	3	303916	4781	64190032
Oliguria	13.48	10.15	116	303803	14460	64180353
Blood viscosity increased	13.48	10.15	11	303908	274	64194539
Atrioventricular block complete	13.47	10.15	115	303804	14303	64180510
Anal fistula	13.46	10.15	4	303915	5249	64189564
Refusal of treatment by patient	13.43	10.15	76	303843	8263	64186550
Inflammatory marker increased	13.43	10.15	12	303907	8439	64186374
Creatinine renal clearance decreased	13.43	10.15	30	303889	14391	64180422
Hemianopia homonymous	13.42	10.15	22	303897	1187	64193626
Mydriasis	13.34	10.15	33	303886	15279	64179534
Medical device site haemorrhage	13.34	10.15	9	303910	166	64194647
Cardioactive drug level decreased	13.29	10.15	9	303910	167	64194646
Vision blurred	13.24	10.15	324	303595	89992	64104821
Gastrointestinal angiodysplasia	13.21	10.15	19	303900	914	64193899
Personality disorder	13.20	10.15	3	303916	4708	64190105
Blood cholinesterase decreased	13.19	10.15	10	303909	223	64194590
Burning feet syndrome	13.17	10.15	8	303911	122	64194691
Septic shock	13.17	10.15	387	303532	105050	64089763
Gastrointestinal ulcer	13.13	10.15	38	303881	3037	64191776
Renal disorder	13.13	10.15	237	303682	35128	64159685
Premature labour	13.12	10.15	10	303909	7610	64187203
Arteriovenous fistula operation	13.12	10.15	12	303907	350	64194463
Splenic haematoma	13.11	10.15	11	303908	285	64194528
Large intestinal ulcer haemorrhage	13.11	10.15	11	303908	285	64194528
Bronchospasm	13.11	10.15	55	303864	21627	64173186
Congenital tracheomalacia	13.09	10.15	3	303916	0	64194813
Oesophageal ulcer	13.07	10.15	61	303858	6149	64188664
Brain stem haemorrhage	13.06	10.15	25	303894	1526	64193287
Stevens-Johnson syndrome	13.05	10.15	101	303818	34148	64160665
Tricuspid valve incompetence	13.05	10.15	130	303789	16873	64177940
Peptic ulcer	13.05	10.15	55	303864	5308	64189505
Blood pressure diastolic increased	13.03	10.15	19	303900	10733	64184080
Intestinal haemorrhage	12.99	10.15	56	303863	5458	64189355
Human herpesvirus 6 infection	12.96	10.15	3	303916	4651	64190162
Colitis ulcerative	12.96	10.15	60	303859	22968	64171845
Acute respiratory distress syndrome	12.96	10.15	119	303800	38816	64155997
Rales	12.95	10.15	119	303800	15110	64179703
Feeling hot	12.95	10.15	145	303774	45518	64149295
Proctalgia	12.92	10.15	10	303909	7549	64187264
Malignant melanoma	12.88	10.15	26	303893	12938	64181875
Retching	12.87	10.15	119	303800	15137	64179676
Micturition urgency	12.86	10.15	18	303901	10341	64184472
Strangury	12.80	10.15	9	303910	178	64194635
Valvuloplasty cardiac	12.78	10.15	4	303915	9	64194804
Anal abscess	12.74	10.15	10	303909	7498	64187315
Stent placement	12.68	10.15	56	303863	5515	64189298
Subcapsular renal haematoma	12.66	10.15	16	303903	679	64194134
Stress cardiomyopathy	12.61	10.15	15	303904	9242	64185571
Hypophosphataemia	12.61	10.15	32	303887	14688	64180125
Cardioactive drug level above therapeutic	12.57	10.15	10	303909	240	64194573
Vaginal haematoma	12.52	10.15	8	303911	134	64194679
Procalcitonin abnormal	12.52	10.15	11	303908	304	64194509
Infusion site swelling	12.49	10.15	55	303864	5410	64189403
Dyspnoea at rest	12.48	10.15	61	303858	6268	64188545
Diastolic hypotension	12.47	10.15	8	303911	135	64194678
Nausea	12.45	10.15	3405	300514	782395	63412418
Central nervous system lesion	12.44	10.15	23	303896	11826	64182987
Drain placement	12.42	10.15	8	303911	136	64194677
Hyperthermia	12.42	10.15	35	303884	15515	64179298
Protein-losing gastroenteropathy	12.40	10.15	14	303905	527	64194286
Hepatic encephalopathy	12.39	10.15	54	303865	21012	64173801
Haemorrhoids	12.39	10.15	170	303749	23831	64170982
Dysentery	12.39	10.15	18	303901	874	64193939
Euglycaemic diabetic ketoacidosis	12.35	10.15	5	303914	5405	64189408
Cardiomegaly	12.33	10.15	168	303751	23516	64171297
Aortic valve incompetence	12.30	10.15	74	303845	8227	64186586
Gamma-glutamyltransferase increased	12.24	10.15	158	303761	48352	64146461
Application site odour	12.22	10.15	5	303914	30	64194783
Device related thrombosis	12.22	10.15	29	303890	2056	64192757
Mucormycosis	12.18	10.15	10	303909	7331	64187482
Affective disorder	12.17	10.15	8	303911	6572	64188241
Prostatic haemorrhage	12.17	10.15	8	303911	141	64194672
Vaginal infection	12.16	10.15	4	303915	4916	64189897
Coronary artery bypass	12.15	10.15	57	303862	5758	64189055
Uterine haemorrhage	12.12	10.15	33	303886	2546	64192267
Grip strength decreased	12.09	10.15	23	303896	11701	64183112
Exposure to toxic agent	12.07	10.15	7	303912	6152	64188661
Amenorrhoea	12.03	10.15	8	303911	6531	64188282
Intra-abdominal fluid collection	12.01	10.15	34	303885	2683	64192130
Arterial haemorrhage	11.97	10.15	30	303889	2201	64192612
Cervical cord compression	11.97	10.15	12	303907	393	64194420
Inhibitory drug interaction	11.97	10.15	41	303878	3586	64191227
Procalcitonin	11.96	10.15	4	303915	12	64194801
Catheter site urticaria	11.96	10.15	5	303914	32	64194781
Emotional disorder	11.92	10.15	26	303893	12581	64182232
Gastrointestinal angiectasia	11.92	10.15	12	303907	395	64194418
Alanine aminotransferase abnormal	11.91	10.15	9	303910	6879	64187934
Purple glove syndrome	11.89	10.15	10	303909	260	64194553
Bovine tuberculosis	11.88	10.15	8	303911	147	64194666
Traumatic haemorrhage	11.85	10.15	20	303899	1106	64193707
Electrolyte imbalance	11.84	10.15	70	303849	25173	64169640
Nodule	11.82	10.15	44	303875	17903	64176910
Incorrect route of product administration	11.80	10.15	63	303856	23235	64171578
Blood pressure systolic increased	11.78	10.15	163	303756	49290	64145523
Exophthalmos	11.75	10.15	24	303895	1536	64193277
Lip swelling	11.74	10.15	95	303824	31812	64163001
Joint range of motion decreased	11.74	10.15	49	303870	19294	64175519
Sickle cell anaemia with crisis	11.69	10.15	53	303866	5279	64189534
Hypertransaminasaemia	11.68	10.15	10	303909	7181	64187632
Myelodysplastic syndrome	11.64	10.15	79	303840	27500	64167313
Anaesthesia	11.63	10.15	12	303907	407	64194406
Gastroenteritis	11.62	10.15	87	303832	29624	64165189
Arterial rupture	11.57	10.15	16	303903	742	64194071
Stress	11.56	10.15	208	303711	60326	64134487
Pelvic haemorrhage	11.56	10.15	8	303911	154	64194659
Polyp	11.54	10.15	62	303857	6611	64188202
Diuretic therapy	11.52	10.15	8	303911	155	64194658
Device adhesion issue	11.50	10.15	5	303914	5181	64189632
Nephropathy toxic	11.50	10.15	43	303876	17471	64177342
Muscle strain	11.48	10.15	72	303847	8122	64186691
Pseudomonal sepsis	11.45	10.15	5	303914	5167	64189646
Disease complication	11.43	10.15	45	303874	4210	64190603
Mediastinal haemorrhage	11.42	10.15	6	303913	68	64194745
Spinal stenosis	11.39	10.15	31	303888	13900	64180913
Lip injury	11.38	10.15	18	303901	942	64193871
Device dislocation	11.34	10.15	151	303768	21027	64173786
Tardive dyskinesia	11.34	10.15	16	303903	9162	64185651
Tendon disorder	11.31	10.15	8	303911	6324	64188489
Left ventricular enlargement	11.29	10.15	15	303904	669	64194144
Dental pulp disorder	11.29	10.15	4	303915	15	64194798
Stent-graft endoleak	11.23	10.15	5	303914	38	64194775
Rehabilitation therapy	11.23	10.15	23	303896	1475	64193338
Enterococcal infection	11.23	10.15	31	303888	13835	64180978
Optic neuritis	11.22	10.15	13	303906	8103	64186710
Cholelithiasis	11.19	10.15	149	303770	45357	64149456
Acquired oesophageal web	11.18	10.15	10	303909	283	64194530
COVID-19 pneumonia	11.18	10.15	40	303879	16464	64178349
Hepatic vein thrombosis	11.14	10.15	9	303910	221	64194592
Inadequate diet	11.14	10.15	9	303910	221	64194592
Hallucination, visual	11.12	10.15	81	303838	27753	64167060
5-hydroxyindolacetic acid increased	11.09	10.15	4	303915	16	64194797
Eye haematoma	11.07	10.15	7	303912	115	64194698
IgM nephropathy	11.02	10.15	3	303916	3	64194810
Factor II mutation	11.02	10.15	3	303916	3	64194810
Biliary tract operation	11.02	10.15	3	303916	3	64194810
Dry skin	11.01	10.15	172	303747	50989	64143824
Photophobia	11.00	10.15	43	303876	17250	64177563
Ischaemic hepatitis	10.98	10.15	37	303882	3209	64191604
Urinary incontinence	10.97	10.15	113	303806	36038	64158775
Heart disease congenital	10.94	10.15	13	303906	517	64194296
Injection site pustule	10.91	10.15	6	303913	75	64194738
Pulmonary resection	10.91	10.15	5	303914	41	64194772
Catheter site extravasation	10.91	10.15	11	303908	363	64194450
Complications of transplanted kidney	10.90	10.15	6	303913	5429	64189384
Aortic aneurysm rupture	10.87	10.15	20	303899	1184	64193629
Thromboembolectomy	10.84	10.15	6	303913	76	64194737
Fungal infection	10.84	10.15	106	303813	34145	64160668
Incarcerated hernia	10.83	10.15	11	303908	366	64194447
Drug abuser	10.82	10.15	7	303912	5801	64189012
Skin fissures	10.82	10.15	20	303899	10286	64184527
Application site pruritus	10.81	10.15	39	303880	3500	64191313
Vaginal haemorrhage	10.81	10.15	139	303780	19205	64175608
Dysaesthesia	10.79	10.15	5	303914	4990	64189823
Investigation	10.77	10.15	29	303890	2223	64192590
Subileus	10.73	10.15	5	303914	4972	64189841
Cystitis haemorrhagic	10.72	10.15	13	303906	7943	64186870
Bladder necrosis	10.72	10.15	4	303915	18	64194795
Intracranial haematoma	10.70	10.15	16	303903	797	64194016
Cushingoid	10.70	10.15	12	303907	7591	64187222
Eye infection	10.67	10.15	17	303902	9264	64185549
Thyrotoxic crisis	10.67	10.15	19	303900	1097	64193716
Salivary hypersecretion	10.63	10.15	26	303893	12087	64182726
Forced expiratory volume decreased	10.62	10.15	10	303909	6857	64187956
Gastrointestinal pain	10.61	10.15	12	303907	7562	64187251
Blood pressure immeasurable	10.60	10.15	26	303893	1882	64192931
Personality change	10.60	10.15	15	303904	8578	64186235
Colon cancer	10.56	10.15	99	303820	12640	64182173
Oropharyngeal discomfort	10.54	10.15	6	303913	5329	64189484
Mitral perforation	10.54	10.15	4	303915	19	64194794
Vessel puncture site haemorrhage	10.53	10.15	8	303911	179	64194634
Cardiac pseudoaneurysm	10.51	10.15	5	303914	45	64194768
Cerebellar infarction	10.50	10.15	37	303882	3282	64191531
Ataxia	10.48	10.15	61	303858	22023	64172790
Nephrosclerosis	10.48	10.15	23	303896	1548	64193265
Hemiplegia	10.47	10.15	99	303820	12669	64182144
Abdominal pain upper	10.47	10.15	697	303222	174333	64020480
Angiodysplasia	10.47	10.15	16	303903	813	64194000
Skin reaction	10.47	10.15	27	303892	12325	64182488
Tri-iodothyronine increased	10.45	10.15	8	303911	181	64194632
Infusion site vesicles	10.45	10.15	11	303908	382	64194431
Coagulation factor V level increased	10.42	10.15	5	303914	46	64194767
Face oedema	10.41	10.15	71	303848	24690	64170123
Erectile dysfunction	10.40	10.15	28	303891	12599	64182214
Eosinophilia	10.37	10.15	122	303797	37954	64156859
Aspartate aminotransferase increased	10.34	10.15	460	303459	119328	64075485
Decreased immune responsiveness	10.33	10.15	4	303915	4444	64190369
Pyelonephritis	10.32	10.15	44	303875	17222	64177591
Coordination abnormal	10.31	10.15	36	303883	14928	64179885
Bipolar disorder	10.27	10.15	10	303909	6751	64188062
Femoral artery aneurysm	10.27	10.15	8	303911	186	64194627
Therapy interrupted	10.25	10.15	54	303865	19982	64174831
Brain natriuretic peptide	10.23	10.15	5	303914	48	64194765
Adnexal torsion	10.23	10.15	8	303911	187	64194626
Heart and lung transplant	10.23	10.15	8	303911	187	64194626
Procedural pain	10.23	10.15	38	303881	15470	64179343
Parathyroid gland operation	10.22	10.15	4	303915	21	64194792
Thyroiditis acute	10.20	10.15	8	303911	188	64194625
Paranoia	10.19	10.15	41	303878	16311	64178502
Large intestinal polypectomy	10.17	10.15	9	303910	251	64194562

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AA03	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Vitamin K antagonists
FDA EPC	N0000175476	Vitamin K Antagonist
CHEBI has role	CHEBI:33288	rodenticides
CHEBI has role	CHEBI:50249	anticoagulants
CHEBI has role	CHEBI:50390	NAD(P)H dehydrogenase (quinone) inhibitors
CHEBI has role	CHEBI:55347	vitamin K antagonists
MeSH PA	D000925	Anticoagulants
MeSH PA	D006401	Hematologic Agents
MeSH PA	D010575	Pesticides
MeSH PA	D012378	Rodenticides
FDA MoA	N0000175964	Vitamin K Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Cerebral embolism	indication	75543006	DOID:4372
Deep venous thrombosis	indication	128053003
Pulmonary thromboembolism	indication	233935004
Thromboembolic disorder	indication	371039008
Thrombosis	indication	439127006
Prevention of deep vein thrombosis	indication	439993001
Prevention of Thromboembolism with Chronic Atrial Fibrillation	indication
Thromboembolism due to Prosthetic Heart Valves	indication
Pulmonary Thromboembolism Prevention	indication
Deep Vein Thrombosis with Pulmonary Embolism	indication
Myocardial Reinfarction Prevention	indication
Thrombophilia	off-label use	234467004	DOID:2452
Heart Failure with Paroxysmal Atrial Fibrillation	off-label use
Nutritional disorder	contraindication	2492009	DOID:374
Pericarditis	contraindication	3238004	DOID:1787
Necrosis	contraindication	6574001
Alcoholism	contraindication	7200002
Obstruction of bile duct	contraindication	30144000
Vasculitis	contraindication	31996006	DOID:865
Hyperthyroidism	contraindication	34486009	DOID:7998
Gangrene	contraindication	36024000
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Secondary uterine inertia	contraindication	43715006
Tropical sprue	contraindication	47384003	DOID:10607
Nephrotic syndrome	contraindication	52254009	DOID:1184
Vitamin K deficiency	contraindication	52675005	DOID:11249
Threatened abortion	contraindication	54048003	DOID:9667
Hyperlipidemia	contraindication	55822004	DOID:1168
Hepatic failure	contraindication	59927004
Cerebrovascular disease	contraindication	62914000	DOID:6713
Blood coagulation disorder	contraindication	64779008	DOID:1247
Fatty stool	contraindication	66187002
Psychotic disorder	contraindication	69322001
Heparin-induced thrombocytopenia	contraindication	73397007
Gastrointestinal hemorrhage	contraindication	74474003
Protein C deficiency disease	contraindication	76407009	DOID:3756
Respiratory tract hemorrhage	contraindication	95431003
Disorder of connective tissue	contraindication	105969002	DOID:65
Polycythemia vera	contraindication	109992005
Procedure on central nervous system	contraindication	118679007
Intracranial aneurysm	contraindication	128609009	DOID:10941
Bleeding	contraindication	131148009
Impaired renal function disorder	contraindication	197663003
Eclampsia in pregnancy	contraindication	198992004
Local anesthetic intrathecal block	contraindication	231249005
Disease of liver	contraindication	235856003	DOID:409
Chronic diarrhea	contraindication	236071009
Edema	contraindication	267038008
Anemia	contraindication	271737000	DOID:2355
Cerebral hemorrhage	contraindication	274100004
Lumbar puncture	contraindication	277762005
Pregnancy, function	contraindication	289908002
Bacterial endocarditis	contraindication	301183007
Dissection of aorta	contraindication	308546005
Primary malignant neoplasm	contraindication	372087000
Surgical procedure on eye proper	contraindication	373353005
Pericardial effusion	contraindication	373945007	DOID:118
Fever	contraindication	386661006
Surgical procedure	contraindication	387713003
Severe diarrhea	contraindication	409587002
Traumatic injury	contraindication	417746004
Genitourinary tract hemorrhage	contraindication	417941003
Poor metabolizer due to cytochrome p450 CYP2C9 variant	contraindication	424451001
Hypertensive urgency	contraindication	443482000
Cholesterol Embolism	contraindication
Indwelling Vascular Catheter	contraindication
Severe Diabetes Mellitus	contraindication
Internal Hemorrhage	contraindication
Bleeding Risk Associated with Vitamin-K-Epoxide Reductase (Warfarin-Sensitive) Gene	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.96	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Vitamin K epoxide reductase complex subunit 1	Enzyme	Q9BQB6	VKOR1_HUMAN	INHIBITOR	IC50	7	WOMBAT-PK	CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		Ki	3.98	WOMBAT-PK
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		Ki	4.87	WOMBAT-PK
Proprotein convertase subtilisin/kexin type 7	Enzyme	Q16549	PCSK7_HUMAN		IC50	4.61	CHEMBL
Vitamin K epoxide reductase complex subunit 1-like protein 1	Enzyme	Q8N0U8	VKORL_HUMAN		Ki	4.28	SCIENTIFIC LITERATURE

External reference:

ID	Source
4019972	VUID
N0000148057	NUI
D00564	KEGG_DRUG
129-06-6	SECONDARY_CAS_RN
2610-86-8	SECONDARY_CAS_RN
4018548	VANDF
4019972	VANDF
C0043031	UMLSCUI
CHEBI:10033	CHEBI
CHEMBL1464	ChEMBL_ID
DB00682	DRUGBANK_ID
CHEMBL1200879	ChEMBL_ID
D014859	MESH_DESCRIPTOR_UI
54678486	PUBCHEM_CID
6853	IUPHAR_LIGAND_ID
341	INN_ID
5Q7ZVV76EI	UNII
11289	RXNORM
1258	MMSL
5693	MMSL
d00022	MMSL
002084	NDDF
002085	NDDF
004065	NDDF
372756006	SNOMEDCT_US
41509001	SNOMEDCT_US
48603004	SNOMEDCT_US
63167009	SNOMEDCT_US
CHEMBL1200772	ChEMBL_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1712	TABLET	1 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1713	TABLET	2 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1714	TABLET	2.50 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1715	TABLET	3 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1716	TABLET	4 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1718	TABLET	6 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1720	TABLET	10 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1721	TABLET	5 mg	ORAL	ANDA	29 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1723	TABLET	7.50 mg	ORAL	ANDA	29 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1211	TABLET	1 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1212	TABLET	2 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1213	TABLET	2.50 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1214	TABLET	3 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1215	TABLET	4 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1216	TABLET	5 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1217	TABLET	6 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1218	TABLET	7.50 mg	ORAL	ANDA	30 sections
Jantoven	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1219	TABLET	10 mg	ORAL	ANDA	30 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	16590-340	TABLET	2.50 mg	ORAL	ANDA	31 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	16590-341	TABLET	5 mg	ORAL	ANDA	31 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	17856-4034	TABLET	7.50 mg	ORAL	ANDA	32 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-672	TABLET	1 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-673	TABLET	2 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-674	TABLET	2.50 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-675	TABLET	3 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-677	TABLET	5 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-801	TABLET	10 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-939	TABLET	10 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	21695-940	TABLET	10 mg	ORAL	ANDA	24 sections
Warfarin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	31722-327	TABLET	1 mg	ORAL	ANDA	28 sections