warfarin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2847 81-81-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • warfarin
  • warfarin sodium
  • warfarin potassium
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
  • Molecular weight: 308.33
  • Formula: C19H16O4
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -3.82
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
7.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.54 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.13 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.06 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 29 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 8, 1954 FDA BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 8172.47 10.08 3715 183397 39437 50378575
Drug interaction 1143.56 10.08 2373 184739 197248 50220764
Calciphylaxis 938.30 10.08 357 186755 2281 50415731
Drug ineffective 896.92 10.08 1032 186080 818301 49599711
International normalised ratio abnormal 845.84 10.08 338 186774 2505 50415507
International normalised ratio decreased 842.63 10.08 376 186736 3772 50414240
Pulmonary arterial hypertension 837.21 10.08 654 186458 19665 50398347
Dyspnoea 602.11 10.08 3763 183349 543845 49874167
Fluid retention 582.23 10.08 822 186290 49827 50368185
Gastrointestinal haemorrhage 524.96 10.08 959 186153 72362 50345650
International normalised ratio fluctuation 514.67 10.08 220 186892 1970 50416042
Anticoagulation drug level above therapeutic 513.91 10.08 185 186927 987 50417025
Haematoma 478.13 10.08 577 186535 29933 50388079
Haemorrhage 448.80 10.08 750 186362 52691 50365321
Synovitis 414.16 10.08 9 187103 123856 50294156
Cardiac failure congestive 411.97 10.08 942 186170 83440 50334572
Epistaxis 398.99 10.08 789 186323 63165 50354847
Pulmonary hypertension 396.80 10.08 551 186561 32866 50385146
Atrial fibrillation 390.83 10.08 1036 186076 100709 50317303
Pain in jaw 381.24 10.08 582 186530 37846 50380166
Subdural haematoma 378.58 10.08 342 186770 12605 50405407
Labelled drug-drug interaction medication error 365.36 10.08 306 186806 10171 50407841
Right ventricular failure 353.35 10.08 361 186751 15532 50402480
Contraindicated product administered 349.65 10.08 64 187048 148894 50269118
Hypervolaemia 341.71 10.08 446 186666 25053 50392959
Drug intolerance 341.30 10.08 193 186919 218911 50199101
Treatment failure 336.58 10.08 53 187059 137584 50280428
Catheter site erythema 334.91 10.08 199 186913 3763 50414249
Infusion related reaction 327.96 10.08 109 187003 169448 50248564
Cerebral haemorrhage 327.08 10.08 450 186662 26602 50391410
Rheumatoid arthritis 326.26 10.08 171 186941 202379 50215633
Dyspnoea exertional 314.61 10.08 628 186484 50605 50367407
Glossodynia 307.67 10.08 34 187078 115535 50302477
Melaena 304.13 10.08 433 186679 26431 50391581
Prothrombin time prolonged 303.78 10.08 256 186856 8582 50409430
Alopecia 298.30 10.08 280 186832 244767 50173245
Joint swelling 290.75 10.08 287 186825 244999 50173013
Cardiac failure 285.54 10.08 768 186344 75272 50342740
Device related infection 281.44 10.08 365 186747 20370 50397642
Off label use 277.60 10.08 868 186244 473558 49944454
Haemoglobin decreased 264.44 10.08 1050 186062 126166 50291846
Hand deformity 262.89 10.08 31 187081 100168 50317844
Catheter site pain 262.03 10.08 167 186945 3595 50414417
Therapeutic product effect decreased 256.91 10.08 91 187021 135959 50282053
Coagulopathy 254.75 10.08 323 186789 17621 50400391
Drug hypersensitivity 254.73 10.08 333 186779 250677 50167335
Catheter management 240.50 10.08 141 186971 2598 50415414
Systemic lupus erythematosus 239.54 10.08 110 187002 140512 50277500
Abdominal wall haematoma 239.35 10.08 140 186972 2568 50415444
Arthropathy 238.80 10.08 144 186968 157762 50260250
Arthralgia 234.29 10.08 835 186277 437867 49980145
Transfusion 230.34 10.08 261 186851 12644 50405368
Anaemia 216.21 10.08 1635 185477 250821 50167191
Rectal haemorrhage 214.69 10.08 454 186658 38104 50379908
Oedema peripheral 213.38 10.08 1149 185963 156812 50261200
Anticoagulation drug level below therapeutic 208.53 10.08 82 187030 579 50417433
Pericarditis 207.26 10.08 24 187088 78665 50339347
Haemorrhage intracranial 205.29 10.08 241 186871 12133 50405879
Thrombosis 196.69 10.08 551 186561 55282 50362730
Syncope 193.31 10.08 824 186288 102178 50315834
Catheter site discharge 193.15 10.08 107 187005 1761 50416251
Musculoskeletal stiffness 190.28 10.08 120 186992 128361 50289651
Hypersensitivity 190.27 10.08 314 186798 214847 50203165
Haemoptysis 187.28 10.08 338 186774 25235 50392777
Catheter site pruritus 186.98 10.08 107 187005 1880 50416132
Pain 183.24 10.08 1322 185790 577581 49840431
Rash 181.99 10.08 916 186196 436555 49981457
Haematuria 179.31 10.08 332 186780 25281 50392731
Catheter site infection 176.55 10.08 138 186974 4148 50413864
Hypotension 174.22 10.08 1475 185637 233994 50184018
Hepatic enzyme increased 174.12 10.08 151 186961 137229 50280783
Oedema 170.35 10.08 609 186503 69572 50348440
Muscle haemorrhage 166.53 10.08 115 186997 2843 50415169
Central venous catheterisation 164.59 10.08 101 187011 2029 50415983
Infusion site pain 156.21 10.08 210 186902 12136 50405876
Discomfort 155.34 10.08 105 187007 108275 50309737
Wound 153.64 10.08 101 187011 105693 50312319
Hospitalisation 152.66 10.08 575 186537 67362 50350650
Catheter site haemorrhage 150.61 10.08 106 187006 2704 50415308
Device leakage 150.07 10.08 144 186968 5734 50412278
Death 146.38 10.08 1841 185271 323538 50094474
Heparin-induced thrombocytopenia 142.78 10.08 118 186994 3847 50414165
Duodenal ulcer perforation 142.70 10.08 6 187106 45605 50372407
Helicobacter infection 139.11 10.08 12 187100 49690 50368322
Stomatitis 137.61 10.08 104 187008 101240 50316772
Device alarm issue 136.68 10.08 77 187035 1311 50416701
Ecchymosis 136.40 10.08 178 186934 9991 50408021
Exposure during pregnancy 132.66 10.08 151 186961 120864 50297148
Catheter site swelling 130.84 10.08 74 187038 1270 50416742
Febrile neutropenia 130.35 10.08 102 187010 97565 50320447
Coagulation time prolonged 126.54 10.08 69 187043 1099 50416913
Catheter placement 124.21 10.08 83 187029 1941 50416071
Prothrombin time abnormal 124.01 10.08 49 187063 351 50417661
Product use issue 123.97 10.08 227 186885 149248 50268764
Therapeutic product effect incomplete 122.86 10.08 95 187017 91420 50326592
Oxygen saturation decreased 120.79 10.08 564 186548 72684 50345328
Folliculitis 119.98 10.08 6 187106 39219 50378793
Subdural haemorrhage 118.65 10.08 91 187021 2658 50415354
Retroperitoneal haematoma 117.40 10.08 89 187023 2554 50415458
Infusion site infection 115.74 10.08 72 187040 1483 50416529
Nasal congestion 111.79 10.08 429 186683 50691 50367321
Psoriatic arthropathy 110.71 10.08 20 187092 47012 50371000
Abdominal discomfort 109.11 10.08 463 186649 231178 50186834
Maternal exposure during pregnancy 108.08 10.08 272 186840 159506 50258506
Fall 106.79 10.08 1785 185327 333147 50084865
Irritable bowel syndrome 106.73 10.08 29 187083 51412 50366600
Muscle injury 106.53 10.08 8 187104 37103 50380909
Flushing 106.11 10.08 510 186602 66505 50351507
Deep vein thrombosis 104.84 10.08 542 186570 72762 50345250
Chest pain 104.39 10.08 1056 186056 175826 50242186
Thrombosis in device 99.59 10.08 82 187030 2659 50415353
Catheter site inflammation 98.57 10.08 49 187063 638 50417374
Injection site pain 98.05 10.08 162 186950 110862 50307150
Skin necrosis 97.19 10.08 157 186955 10710 50407302
Sleep disorder due to general medical condition, insomnia type 95.58 10.08 5 187107 31442 50386570
Upper gastrointestinal haemorrhage 95.31 10.08 194 186918 15841 50402171
Cardiac pacemaker insertion 94.22 10.08 90 187022 3563 50414449
Product use in unapproved indication 94.14 10.08 178 186934 115641 50302371
Palpitations 93.35 10.08 634 186478 93872 50324140
Pulmonary embolism 92.67 10.08 669 186443 101035 50316977
Sinusitis 92.45 10.08 322 186790 170236 50247776
Retroperitoneal haemorrhage 91.90 10.08 76 187036 2480 50415532
Bradycardia 90.49 10.08 474 186638 63952 50354060
Infusion site erythema 89.08 10.08 134 186978 8593 50409419
Neutropenia 88.77 10.08 267 186845 147698 50270314
Pneumonia aspiration 87.45 10.08 283 186829 30721 50387291
Depression 86.53 10.08 317 186795 165106 50252906
Presyncope 85.36 10.08 239 186873 23959 50394053
Lung transplant 85.28 10.08 76 187036 2749 50415263
Injection site reaction 83.79 10.08 40 187072 49992 50368020
Psoriasis 83.60 10.08 79 187033 68921 50349091
Haemorrhage subcutaneous 82.21 10.08 73 187039 2628 50415384
Cardiac valve replacement complication 81.82 10.08 28 187084 125 50417887
Pneumonia 80.59 10.08 1898 185214 376503 50041509
Vascular device infection 80.50 10.08 90 187022 4294 50413718
Intentional overdose 79.99 10.08 68 187044 62436 50355576
Drug abuse 79.20 10.08 63 187049 59783 50358229
Malignant neoplasm progression 79.07 10.08 81 187031 68043 50349969
Shock haemorrhagic 77.98 10.08 123 186989 8221 50409791
Blood cholesterol increased 77.08 10.08 55 187057 55160 50362852
Dizziness 77.03 10.08 1748 185364 344621 50073391
Pulmonary oedema 76.42 10.08 371 186741 48567 50369445
Atrial flutter 76.19 10.08 125 186987 8638 50409374
Device occlusion 75.50 10.08 102 187010 5921 50412091
Cardiac disorder 75.33 10.08 337 186775 42642 50375370
Faeces discoloured 75.26 10.08 177 186935 15947 50402065
Lower respiratory tract infection 75.02 10.08 149 186963 95052 50322960
Pulmonary arterial pressure increased 74.31 10.08 76 187036 3272 50414740
Ill-defined disorder 74.27 10.08 56 187056 54598 50363414
Infection 73.44 10.08 359 186753 172595 50245417
Coagulation test abnormal 73.42 10.08 40 187072 636 50417376
Injection site erythema 73.23 10.08 102 187010 74834 50343178
Loss of personal independence in daily activities 72.90 10.08 91 187021 69959 50348053
Intra-abdominal haematoma 72.65 10.08 54 187058 1503 50416509
Catheterisation cardiac 72.58 10.08 82 187030 3958 50414054
Suicidal ideation 72.42 10.08 59 187053 55326 50362686
Completed suicide 72.12 10.08 248 186864 131641 50286371
Hypertension 72.03 10.08 471 186641 210732 50207280
Catheter site rash 71.96 10.08 41 187071 714 50417298
Urticaria 71.27 10.08 243 186869 129318 50288694
Lower gastrointestinal haemorrhage 70.75 10.08 106 187006 6773 50411239
Pulmonary thrombosis 70.25 10.08 111 187001 7430 50410582
Blood pressure decreased 70.20 10.08 399 186713 55510 50362502
Complication associated with device 69.63 10.08 162 186950 14493 50403519
Impaired healing 69.19 10.08 94 187018 69692 50348320
Haematemesis 68.43 10.08 242 186870 27483 50390529
Blister 67.03 10.08 134 186978 85284 50332728
Swelling 66.97 10.08 451 186661 200421 50217591
Multiple sclerosis relapse 66.54 10.08 38 187074 42926 50375086
Haemarthrosis 66.34 10.08 67 187045 2841 50415171
Pruritus 65.59 10.08 701 186411 282867 50135145
Blood loss anaemia 65.30 10.08 112 187000 8027 50409985
Device related sepsis 64.94 10.08 72 187040 3403 50414609
Haemorrhagic stroke 64.72 10.08 88 187024 5140 50412872
Cerebrovascular accident 64.57 10.08 583 186529 94097 50323915
Leukopenia 63.92 10.08 94 187018 67434 50350578
Hypocoagulable state 63.82 10.08 41 187071 895 50417117
Dialysis 63.13 10.08 120 186992 9318 50408694
Device expulsion 62.18 10.08 15 187097 28807 50389205
Internal haemorrhage 61.87 10.08 79 187033 4338 50413674
Paraesthesia 61.82 10.08 232 186880 120011 50298001
Therapy change 60.26 10.08 85 187027 5140 50412872
Sleep disorder 60.04 10.08 74 187038 57209 50360803
Anaphylactic reaction 59.69 10.08 67 187045 53988 50364024
Spinal epidural haematoma 59.35 10.08 40 187072 949 50417063
Activated partial thromboplastin time prolonged 59.31 10.08 94 187018 6308 50411704
Cardioactive drug level increased 59.15 10.08 53 187059 1931 50416081
General physical health deterioration 57.40 10.08 301 186811 142133 50275879
Osteoarthritis 57.00 10.08 104 187008 68502 50349510
Subarachnoid haemorrhage 56.64 10.08 124 186988 10652 50407360
Cardiac operation 55.87 10.08 60 187052 2735 50415277
Gastrointestinal disorder 55.51 10.08 172 186940 94284 50323728
Dermatitis contact 55.46 10.08 108 187004 8538 50409474
Injection site pruritus 55.43 10.08 41 187071 40370 50377642
Spontaneous haematoma 55.01 10.08 35 187077 751 50417261
Asthenia 54.89 10.08 1556 185556 317486 50100526
Subcutaneous haematoma 54.37 10.08 45 187067 1470 50416542
Device infusion issue 54.12 10.08 43 187069 1324 50416688
Intra-abdominal haemorrhage 54.07 10.08 53 187059 2167 50415845
Cardiac ablation 54.02 10.08 42 187070 1252 50416760
Pulmonary endarterectomy 53.88 10.08 20 187092 118 50417894
Mucosal inflammation 53.43 10.08 42 187070 40100 50377912
Fibromyalgia 52.73 10.08 53 187059 44925 50373087
Type 2 diabetes mellitus 52.39 10.08 31 187081 34344 50383668
Seizure 51.56 10.08 242 186870 117632 50300380
Therapeutic response decreased 50.57 10.08 60 187052 47171 50370841
Food interaction 50.41 10.08 31 187081 625 50417387
Injection site swelling 50.39 10.08 48 187064 41725 50376287
Acute kidney injury 50.30 10.08 1150 185962 226908 50191104
Transplant evaluation 49.99 10.08 37 187075 1023 50416989
Acute respiratory failure 49.92 10.08 225 186887 28557 50389455
Malaise 49.54 10.08 1606 185506 333926 50084086
Red blood cell sedimentation rate increased 48.52 10.08 24 187088 29392 50388620
Intraventricular haemorrhage 48.09 10.08 46 187066 1824 50416188
Fatigue 47.90 10.08 2135 184977 705466 49712546
Wrong technique in product usage process 47.14 10.08 83 187029 55427 50362585
Hypoaesthesia 46.87 10.08 277 186835 126980 50291032
Head injury 46.42 10.08 194 186918 23826 50394186
Haemoperitoneum 46.14 10.08 52 187060 2503 50415509
Catheter site irritation 45.93 10.08 27 187085 500 50417512
C-reactive protein increased 45.81 10.08 112 187000 66362 50351650
Pericardial haemorrhage 45.56 10.08 40 187072 1418 50416594
Choroidal haemorrhage 45.45 10.08 14 187098 41 50417971
Prosthetic cardiac valve thrombosis 45.14 10.08 12 187100 16 50417996
Torsade de pointes 44.83 10.08 120 186992 11715 50406297
Oxygen consumption increased 44.50 10.08 60 187052 3476 50414536
Infusion site discharge 44.12 10.08 28 187084 598 50417414
Mobility decreased 43.90 10.08 150 186962 79798 50338214
Pelvic haematoma 43.55 10.08 26 187086 496 50417516
Hypoxia 43.52 10.08 331 186781 50792 50367220
Vascular pseudoaneurysm 43.31 10.08 38 187074 1346 50416666
Post procedural haemorrhage 43.25 10.08 88 187024 7182 50410830
Medical device change 43.23 10.08 22 187090 302 50417710
Gout 43.14 10.08 116 186996 11354 50406658
Anxiety 42.66 10.08 435 186677 177171 50240841
Gastric haemorrhage 42.60 10.08 76 187036 5620 50412392
Catheter site related reaction 42.60 10.08 30 187082 766 50417246
Potentiating drug interaction 42.42 10.08 61 187051 3755 50414257
Inflammation 42.35 10.08 92 187020 56820 50361192
Hypercoagulation 42.03 10.08 43 187069 1852 50416160
Emergency care 41.34 10.08 30 187082 804 50417208
Anticoagulation drug level decreased 40.90 10.08 12 187100 28 50417984
Prothrombin time ratio increased 40.34 10.08 15 187097 89 50417923
Haematoma muscle 40.27 10.08 28 187084 700 50417312
Haematocrit decreased 40.26 10.08 244 186868 34732 50383280
Traumatic haematoma 40.19 10.08 36 187076 1311 50416701
Brain natriuretic peptide increased 39.93 10.08 65 187047 4462 50413550
Gingival bleeding 39.90 10.08 112 187000 11241 50406771
Cellulitis 39.46 10.08 418 186694 70380 50347632
Intentional self-injury 39.43 10.08 18 187094 23094 50394918
Cardioversion 39 10.08 33 187079 1112 50416900
Muscle spasticity 38.97 10.08 8 187104 17176 50400836
Anticoagulation drug level abnormal 38.86 10.08 9 187103 3 50418009
Dyspnoea at rest 38.66 10.08 57 187055 3590 50414422
Catheter site discolouration 38.62 10.08 15 187097 102 50417910
International normalised ratio 38.53 10.08 14 187098 77 50417935
Intentional product use issue 37.22 10.08 152 186960 76766 50341246
Occult blood positive 37.16 10.08 53 187059 3238 50414774
Congestive hepatopathy 37.15 10.08 46 187066 2448 50415564
Anticoagulant-related nephropathy 36.83 10.08 8 187104 0 50418012
Foetal warfarin syndrome 36.83 10.08 8 187104 0 50418012
Protein C decreased 36.82 10.08 11 187101 28 50417984
Cardiac failure chronic 36.78 10.08 55 187057 3508 50414504
Arthritis 36.77 10.08 180 186932 86541 50331471
Device breakage 36.36 10.08 97 187015 9450 50408562
Spinal cord haematoma 36.24 10.08 16 187096 156 50417856
Cerebellar haemorrhage 36.20 10.08 33 187079 1230 50416782
Intestinal haematoma 36.11 10.08 12 187100 48 50417964
Tongue haematoma 36.01 10.08 13 187099 70 50417942
Unevaluable event 35.76 10.08 292 186820 45774 50372238
Catheter removal 35.53 10.08 20 187092 340 50417672
Anticoagulation drug level increased 35.46 10.08 16 187096 165 50417847
Embolism 35.29 10.08 79 187033 6889 50411123
Drug monitoring procedure not performed 35.20 10.08 22 187090 457 50417555
Suicide attempt 34.98 10.08 88 187024 51644 50366368
Heart valve replacement 34.95 10.08 22 187090 463 50417549
Dizziness postural 34.93 10.08 73 187039 6072 50411940
Infusion site haemorrhage 34.84 10.08 49 187063 2955 50415057
Asthma 34.20 10.08 192 186920 89145 50328867
Device connection issue 34.19 10.08 23 187089 544 50417468
Haematoma evacuation 33.82 10.08 15 187097 148 50417864
Brain herniation 33.75 10.08 49 187063 3043 50414969
Catheter culture positive 33.58 10.08 14 187098 117 50417895
Spinal subdural haematoma 33.58 10.08 14 187098 117 50417895
Arrhythmia 33.11 10.08 223 186889 32909 50385103
Cognitive disorder 33.10 10.08 71 187041 44052 50373960
Gangrene 33.05 10.08 61 187051 4631 50413381
Oxygen therapy 32.93 10.08 37 187075 1775 50416237
Pleural effusion 32.74 10.08 452 186660 81002 50337010
Foot deformity 32.71 10.08 15 187097 19195 50398817
Ovarian haemorrhage 32.61 10.08 18 187094 294 50417718
Oral herpes 32.56 10.08 18 187094 20707 50397305
Skin weeping 32.49 10.08 20 187092 404 50417608
Pericardial effusion 32.36 10.08 183 186929 25406 50392606
Pregnancy 32.28 10.08 37 187075 29540 50388472
Blood viscosity decreased 32.16 10.08 11 187101 49 50417963
Mineral supplementation 32.07 10.08 24 187088 675 50417337
Infusion site cellulitis 32.00 10.08 15 187097 170 50417842
Hyperkalaemia 31.69 10.08 294 186818 47795 50370217
Vascular pseudoaneurysm ruptured 31.47 10.08 11 187101 53 50417959
Pancytopenia 31.41 10.08 182 186930 83848 50334164
Prothrombin consumption time prolonged 31.13 10.08 10 187102 35 50417977
Pulmonary haemorrhage 31.10 10.08 72 187040 6420 50411592
Cough 30.83 10.08 1136 185976 240128 50177884
Cardiac failure acute 30.59 10.08 83 187029 8167 50409845
Eye haemorrhage 30.48 10.08 77 187035 7258 50410754
Aortic valve replacement 30.34 10.08 23 187089 660 50417352
Acute myeloid leukaemia 30.33 10.08 9 187103 15065 50402947
Serotonin syndrome 30.27 10.08 28 187084 24685 50393327
Central venous catheter removal 30.21 10.08 18 187094 342 50417670
Headache 30.15 10.08 2217 184895 504318 49913694
Renal failure 30.15 10.08 558 186554 106075 50311937
Pyrexia 30.11 10.08 1126 185986 379077 50038935
Foetal exposure during pregnancy 30.10 10.08 34 187078 27325 50390687
Psychotic disorder 30.08 10.08 22 187090 21790 50396222
Adrenal haemorrhage 29.97 10.08 19 187093 405 50417607
Ventricular tachycardia 29.96 10.08 127 186985 15694 50402318
Catheter site warmth 29.73 10.08 15 187097 202 50417810
Generalised tonic-clonic seizure 29.71 10.08 32 187080 26278 50391734
Atrial tachycardia 29.66 10.08 38 187074 2094 50415918
Accidental exposure to product 29.59 10.08 25 187087 23032 50394980
Orthopnoea 29.37 10.08 65 187047 5624 50412388
Renal vascular thrombosis 29.34 10.08 10 187102 44 50417968
Ascites 29.30 10.08 230 186882 35631 50382381
Myelosuppression 29.22 10.08 7 187105 13510 50404502
Knee arthroplasty 29.18 10.08 55 187057 35791 50382221
Basal cell carcinoma 29.16 10.08 26 187086 23330 50394682
Protein S decreased 29.06 10.08 9 187103 27 50417985
Contusion 28.97 10.08 579 186533 111604 50306408
Haemothorax 28.87 10.08 36 187076 1930 50416082
Rheumatoid nodule 28.73 10.08 6 187106 12729 50405283
Neutrophil count decreased 28.33 10.08 82 187030 45944 50372068
Atrial thrombosis 28.29 10.08 31 187081 1446 50416566
Toxicity to various agents 28.26 10.08 585 186527 211914 50206098
COVID-19 28.09 10.08 84 187028 46578 50371434
Angioedema 27.95 10.08 61 187051 37615 50380397
Catheter site vesicles 27.66 10.08 16 187096 287 50417725
Infusion site irritation 27.66 10.08 21 187091 604 50417408
Cardiac valve disease 27.66 10.08 50 187062 3736 50414276
Heart rate increased 27.61 10.08 420 186692 76830 50341182
Hypovolaemic shock 27.61 10.08 60 187052 5128 50412884
Antiphospholipid syndrome 27.61 10.08 31 187081 1486 50416526
Mediastinal haematoma 27.58 10.08 11 187101 81 50417931
Calcium deficiency 27.58 10.08 25 187087 925 50417087
Heart rate irregular 27.55 10.08 143 186969 19217 50398795
Respiratory failure 27.49 10.08 482 186630 90699 50327313
Infusion site swelling 27.42 10.08 73 187039 7103 50410909
Infusion site warmth 27.30 10.08 30 187082 1404 50416608
Drug dependence 27.16 10.08 20 187092 19739 50398273
Ischaemic stroke 27.15 10.08 124 186988 15824 50402188
Disturbance in attention 27.05 10.08 46 187066 31140 50386872
Drug level changed 26.94 10.08 13 187099 158 50417854
Osteoporosis 26.87 10.08 81 187031 44798 50373214
Cerebral haematoma 26.84 10.08 45 187067 3166 50414846
Sedation 26.69 10.08 45 187067 30565 50387447
Cerebral mass effect 26.59 10.08 23 187089 799 50417213
Extradural haematoma 26.47 10.08 31 187081 1556 50416456
Blood potassium decreased 26.46 10.08 230 186882 36715 50381297
Stress 26.21 10.08 106 187006 53687 50364325
Anovulatory cycle 26.16 10.08 12 187100 129 50417883
Ear pain 26.15 10.08 40 187072 28243 50389769
Bursitis 26.04 10.08 26 187086 22109 50395903
Blood viscosity increased 25.90 10.08 14 187098 219 50417793
Sciatic nerve palsy 25.83 10.08 8 187104 24 50417988
Intestinal haemorrhage 25.83 10.08 44 187068 3136 50414876
Intracardiac thrombus 25.82 10.08 36 187076 2153 50415859
Blood pressure increased 25.76 10.08 342 186770 132790 50285222
Product complaint 25.69 10.08 97 187015 11369 50406643
Palmar-plantar erythrodysaesthesia syndrome 25.54 10.08 22 187090 20076 50397936
Breast necrosis 25.45 10.08 12 187100 138 50417874
Injection site discharge 25.42 10.08 17 187095 398 50417614
Hip arthroplasty 25.38 10.08 46 187066 30383 50387629
Abortion spontaneous 25.29 10.08 75 187037 41697 50376315
Bradyarrhythmia 25.22 10.08 33 187079 1857 50416155
No adverse event 25.21 10.08 54 187058 33524 50384488
Vitamin K deficiency 25.13 10.08 17 187095 406 50417606
Infusion site abscess 25.07 10.08 13 187099 186 50417826
Breast haematoma 25.01 10.08 13 187099 187 50417825
Thyroid haemorrhage 24.70 10.08 9 187103 50 50417962
Disease complication 24.61 10.08 40 187072 2742 50415270
Mitral valve disease 24.41 10.08 34 187078 2032 50415980
Tuberculosis 24.36 10.08 4 187108 10079 50407933
Dilatation ventricular 24.16 10.08 36 187076 2289 50415723
Abdominal distension 24.02 10.08 391 186721 72512 50345500
Endarterectomy 24.02 10.08 12 187100 158 50417854
Hepatotoxicity 23.76 10.08 40 187072 27186 50390826
Cytomegalovirus infection 23.64 10.08 19 187093 17943 50400069
Hypoprothrombinaemia 23.64 10.08 14 187098 263 50417749
Myxoedema coma 23.62 10.08 16 187096 383 50417629
Neuroleptic malignant syndrome 23.60 10.08 6 187106 11124 50406888
Atrial septal defect repair 23.57 10.08 13 187099 212 50417800
Right ventricular dysfunction 23.48 10.08 29 187083 1539 50416473
Injury 23.47 10.08 97 187015 48828 50369184
Haematochezia 23.41 10.08 238 186874 39644 50378368
Insomnia 23.36 10.08 481 186631 174384 50243628
Petechiae 23.35 10.08 100 187012 12412 50405600
Sepsis 23.25 10.08 650 186462 132275 50285737
Immunodeficiency 23.12 10.08 13 187099 14815 50403197
Infusion site oedema 23.08 10.08 18 187094 539 50417473
Haemorrhagic ovarian cyst 23.02 10.08 19 187093 618 50417394
Blood viscosity abnormal 23.02 10.08 5 187107 0 50418012
Colitis 22.74 10.08 70 187042 38459 50379553
Gastrooesophageal reflux disease 22.67 10.08 403 186709 76025 50341987
Neoplasm progression 22.64 10.08 46 187066 29111 50388901
Haemorrhagic diathesis 22.56 10.08 47 187065 3901 50414111
Herpes zoster 22.53 10.08 161 186951 70625 50347387
Compartment syndrome 22.50 10.08 32 187080 1950 50416062
Protein S deficiency 22.13 10.08 7 187105 23 50417989
Coagulation time shortened 22.07 10.08 11 187101 144 50417868
Prothrombin level abnormal 21.93 10.08 9 187103 72 50417940
Cytokine release syndrome 21.83 10.08 3 187109 8631 50409381
Mouth haemorrhage 21.65 10.08 61 187051 6135 50411877
Scleroderma 21.64 10.08 52 187060 4749 50413263
Pulmonary arterial pressure abnormal 21.60 10.08 16 187096 443 50417569
Tendonitis 21.58 10.08 18 187094 16687 50401325
Adverse drug reaction 21.50 10.08 118 186994 55104 50362908
Vaginal haemorrhage 21.47 10.08 160 186952 24391 50393621
Gastric antral vascular ectasia 21.30 10.08 17 187095 527 50417485
Atrioventricular block complete 21.16 10.08 67 187045 7188 50410824
Joint stiffness 20.92 10.08 51 187061 30257 50387755
Drug withdrawal syndrome 20.84 10.08 38 187074 25043 50392969
Mitral valve repair 20.75 10.08 11 187101 165 50417847
Cardiogenic shock 20.68 10.08 113 186999 15486 50402526
Medical device site thrombosis 20.68 10.08 5 187107 3 50418009
Catheter site nodule 20.65 10.08 8 187104 54 50417958
Drug resistance 20.45 10.08 24 187088 18965 50399047
Injection site warmth 20.44 10.08 13 187099 13853 50404159
Catheter site dermatitis 20.40 10.08 8 187104 56 50417956
Lupus-like syndrome 20.35 10.08 5 187107 9486 50408526
Infusion site pruritus 20.35 10.08 45 187067 3892 50414120
Drug eruption 20.31 10.08 35 187077 23571 50394441
Dizziness exertional 20.27 10.08 14 187098 346 50417666
Blood culture negative 20.13 10.08 10 187102 130 50417882
Injection site urticaria 20.10 10.08 10 187102 12207 50405805
Spinal subarachnoid haemorrhage 20.10 10.08 5 187107 4 50418008
Heart valve operation 20.06 10.08 10 187102 131 50417881
Ovarian rupture 19.98 10.08 7 187105 34 50417978
Abdominal wall haemorrhage 19.80 10.08 10 187102 135 50417877
Device difficult to use 19.71 10.08 6 187106 9880 50408132
Aortic stenosis 19.53 10.08 46 187066 4148 50413864
Application site pruritus 19.47 10.08 43 187069 3716 50414296
Hip fracture 19.39 10.08 163 186949 25768 50392244
Liver injury 19.38 10.08 39 187073 24767 50393245
Breast cancer 19.37 10.08 87 187025 42803 50375209
Walking distance test abnormal 19.35 10.08 16 187096 522 50417490
Lethargy 19.33 10.08 273 186839 49159 50368853
Drug tolerance decreased 19.31 10.08 5 187107 9155 50408857
Dystonia 19.26 10.08 10 187102 11916 50406096
Lymphocyte count decreased 19.18 10.08 43 187069 26264 50391748
Blood pressure fluctuation 19.13 10.08 68 187044 35755 50382257
Oral mucosa haematoma 19.10 10.08 5 187107 6 50418006
Cholecystitis chronic 19.04 10.08 6 187106 9663 50408349
Injection site rash 19.03 10.08 19 187093 16158 50401854
Dehydration 19.01 10.08 716 186396 151733 50266279
Cardiac flutter 18.95 10.08 40 187072 3350 50414662
Multiple sclerosis 18.93 10.08 29 187083 20464 50397548
Gastrointestinal arteriovenous malformation 18.89 10.08 16 187096 540 50417472
Cardiomegaly 18.83 10.08 112 187000 15833 50402179
Acne 18.81 10.08 27 187085 19568 50398444
Coagulation factor decreased 18.76 10.08 7 187105 42 50417970
Gait disturbance 18.75 10.08 417 186695 149588 50268424
Pneumocystis jirovecii pneumonia 18.69 10.08 16 187096 14647 50403365
Nephrosclerosis 18.69 10.08 20 187092 908 50417104
Cardioactive drug level decreased 18.68 10.08 8 187104 72 50417940
Product storage error 18.66 10.08 11 187101 12213 50405799
Device dislocation 18.61 10.08 140 186972 21406 50396606
Catheter site oedema 18.49 10.08 7 187105 44 50417968
Skin exfoliation 18.49 10.08 63 187049 33549 50384463
Prescribed underdose 18.46 10.08 19 187093 15930 50402082
Dry eye 18.45 10.08 59 187053 32036 50385976
Tracheal calcification 18.42 10.08 4 187108 0 50418012
Femoral nerve palsy 18.42 10.08 4 187108 0 50418012
Valvuloplasty cardiac 18.42 10.08 4 187108 0 50418012
Polyneuropathy 18.40 10.08 11 187101 12120 50405892
Diarrhoea 18.38 10.08 2463 184649 586013 49831999
Aortic dissection 18.37 10.08 26 187086 1577 50416435
Conjunctival haemorrhage 18.29 10.08 37 187075 3007 50415005
Balloon atrial septostomy 18.12 10.08 8 187104 78 50417934
Renal disorder 18.04 10.08 168 186944 27337 50390675
Sinus node dysfunction 18.00 10.08 43 187069 3912 50414100
Gestational diabetes 17.95 10.08 3 187109 7462 50410550
Hepatorenal failure 17.76 10.08 16 187096 587 50417425
Haemophagocytic lymphohistiocytosis 17.65 10.08 5 187107 8628 50409384
Retching 17.61 10.08 94 187018 12768 50405244
Concomitant disease progression 17.55 10.08 29 187083 2016 50415996
Mood swings 17.36 10.08 20 187092 15934 50402078
Nocturnal dyspnoea 17.20 10.08 20 187092 996 50417016
Metastases to liver 17.12 10.08 30 187082 20074 50397938
White blood cell count decreased 17.12 10.08 316 186796 116406 50301606
Abdominal cavity drainage 17.09 10.08 13 187099 375 50417637
Body temperature increased 17.06 10.08 59 187053 31282 50386730
Exercise tolerance decreased 17.05 10.08 48 187064 4826 50413186
Thoracic haemorrhage 16.98 10.08 6 187106 30 50417982
Catheter site dryness 16.98 10.08 6 187106 30 50417982
Injection site bruising 16.95 10.08 74 187038 36694 50381318
Aphthous ulcer 16.95 10.08 9 187103 10588 50407424
Drain placement 16.84 10.08 7 187105 58 50417954
Jugular vein distension 16.81 10.08 18 187094 818 50417194
Central nervous system lesion 16.80 10.08 7 187105 9482 50408530
Large intestinal polypectomy 16.74 10.08 10 187102 191 50417821
Mitral valve replacement 16.70 10.08 11 187101 251 50417761
Aggression 16.66 10.08 33 187079 21083 50396929
Subarachnoid haematoma 16.66 10.08 5 187107 13 50417999
Endocarditis 16.61 10.08 49 187063 5058 50412954
Blue toe syndrome 16.57 10.08 13 187099 393 50417619
Neurotoxicity 16.56 10.08 18 187094 14722 50403290
Metastases to lymph nodes 16.50 10.08 3 187109 7021 50410991
Night sweats 16.45 10.08 66 187046 33508 50384504
Pulmonary alveolar haemorrhage 16.45 10.08 42 187070 3985 50414027
Suture insertion 16.38 10.08 8 187104 100 50417912
Anaphylactic shock 16.34 10.08 31 187081 20124 50397888
Therapy interrupted 16.33 10.08 31 187081 20121 50397891
Stent placement 16.33 10.08 38 187074 3400 50414612
Thrombectomy 16.30 10.08 9 187103 147 50417865
Cardiac pacemaker replacement 16.30 10.08 12 187100 329 50417683
Dysentery 16.21 10.08 17 187095 754 50417258
Purple glove syndrome 16.20 10.08 10 187102 203 50417809
Device related thrombosis 16.18 10.08 22 187090 1285 50416727
Pancreatitis 16.08 10.08 92 187020 42522 50375490
Coeliac disease 16.05 10.08 6 187106 8679 50409333
Drug-induced liver injury 15.90 10.08 52 187060 28043 50389969
Spinal stenosis 15.84 10.08 16 187096 13534 50404478
Hyphaema 15.83 10.08 9 187103 156 50417856
Diabetic ketoacidosis 15.83 10.08 26 187086 17846 50400166
Mouth ulceration 15.77 10.08 52 187060 27972 50390040
Exostosis 15.75 10.08 12 187100 11641 50406371
Coma scale normal 15.66 10.08 4 187108 4 50418008
Oesophageal compression 15.66 10.08 4 187108 4 50418008
Hypercalcaemia 15.57 10.08 40 187072 23312 50394700
Myocarditis 15.53 10.08 5 187107 7942 50410070
Lymphopenia 15.52 10.08 21 187091 15600 50402412
Carpal tunnel syndrome 15.51 10.08 24 187088 16869 50401143
Panniculitis 15.50 10.08 6 187106 8497 50409515
Iron deficiency anaemia 15.46 10.08 111 187001 16723 50401289
Cardiac arrest 15.45 10.08 412 186700 83239 50334773
Exophthalmos 15.41 10.08 21 187091 1229 50416783
Arteriovenous malformation 15.31 10.08 21 187091 1237 50416775
Ovarian cyst ruptured 15.30 10.08 19 187093 1014 50416998
Accidental overdose 15.26 10.08 124 186988 19409 50398603
Progressive multifocal leukoencephalopathy 15.23 10.08 12 187100 11445 50406567
Withdrawal syndrome 15.20 10.08 26 187086 17564 50400448
Metastases to bone 15.19 10.08 27 187085 17968 50400044
Prothrombin level increased 15.18 10.08 10 187102 228 50417784
Cor pulmonale 15.18 10.08 26 187086 1861 50416151
Endotracheal intubation 15.17 10.08 28 187084 2126 50415886
Heart sounds abnormal 15.07 10.08 15 187097 625 50417387
Duodenal ulcer haemorrhage 15.06 10.08 28 187084 2138 50415874
Impaired work ability 14.95 10.08 17 187095 13623 50404389
Eschar 14.95 10.08 13 187099 455 50417557
Tri-iodothyronine increased 14.92 10.08 8 187104 123 50417889
Chronic respiratory failure 14.84 10.08 24 187088 1638 50416374
Traumatic intracranial haemorrhage 14.82 10.08 12 187100 380 50417632
Aplastic anaemia 14.78 10.08 5 187107 7698 50410314
Subdural haematoma evacuation 14.77 10.08 4 187108 6 50418006
Hepatocellular injury 14.70 10.08 48 187064 25899 50392113
Migraine 14.69 10.08 193 186919 75087 50342925
Cerebral infarction 14.69 10.08 133 186979 21471 50396541
Hydrocephalus 14.69 10.08 45 187067 4743 50413269
Hepatitis 14.69 10.08 63 187049 31390 50386622
Diastolic hypotension 14.66 10.08 7 187105 83 50417929
Hypercholesterolaemia 14.64 10.08 13 187099 11690 50406322
Neuropathy peripheral 14.48 10.08 261 186851 96496 50321516
Coagulation factor deficiency 14.40 10.08 4 187108 7 50418005
Uterine haemorrhage 14.35 10.08 36 187076 3379 50414633
Intervertebral disc protrusion 14.33 10.08 34 187078 20359 50397653
Obesity 14.31 10.08 25 187087 16750 50401262
Skin reaction 14.29 10.08 13 187099 11555 50406457
Encephalopathy 14.27 10.08 70 187042 33641 50384371
Vaginal haematoma 14.26 10.08 8 187104 135 50417877
Splenic haemorrhage 14.19 10.08 9 187103 192 50417820
Transaminases increased 14.08 10.08 54 187058 27770 50390242
Inappropriate schedule of product administration 14.08 10.08 184 186928 71647 50346365
Neutropenic sepsis 14.07 10.08 19 187093 14128 50403884
Premature labour 14.06 10.08 13 187099 11463 50406549
Intentional product misuse 14.05 10.08 108 187004 46626 50371386
Lacrimal haemorrhage 13.99 10.08 5 187107 26 50417986
Mitral valve stenosis 13.99 10.08 18 187094 996 50417016
Therapeutic product effect increased 13.96 10.08 18 187094 998 50417014
Osteopenia 13.95 10.08 26 187086 16992 50401020
Right ventricular systolic pressure increased 13.94 10.08 13 187099 499 50417513
Sinus tachycardia 13.92 10.08 37 187075 21317 50396695
Diet noncompliance 13.91 10.08 10 187102 264 50417748
Sickle cell anaemia 13.90 10.08 13 187099 501 50417511
Angioplasty 13.86 10.08 20 187092 1235 50416777
Blood potassium increased 13.85 10.08 106 187006 16292 50401720
Catheter site extravasation 13.84 10.08 10 187102 266 50417746
Thromboembolectomy 13.84 10.08 5 187107 27 50417985
Emergency care examination 13.82 10.08 6 187106 56 50417956
Prothrombin level decreased 13.81 10.08 13 187099 505 50417507
Cardiac pacemaker adjustment 13.81 10.08 3 187109 0 50418012
Craniectomy 13.81 10.08 3 187109 0 50418012
Iris haemorrhage 13.81 10.08 3 187109 0 50418012
Acquired cardiac septal defect 13.81 10.08 3 187109 0 50418012
Hepatic artery embolism 13.81 10.08 3 187109 0 50418012
Adrenal cortex necrosis 13.81 10.08 3 187109 0 50418012
Sleep disorder due to a general medical condition 13.78 10.08 5 187107 7366 50410646
Drug ineffective for unapproved indication 13.77 10.08 37 187075 21244 50396768
Rales 13.71 10.08 73 187039 9905 50408107
Device physical property issue 13.71 10.08 23 187089 1619 50416393
Brain operation 13.71 10.08 13 187099 510 50417502
Haemorrhagic cerebral infarction 13.70 10.08 14 187098 602 50417410
Haematotoxicity 13.70 10.08 6 187106 7889 50410123
Catheter site urticaria 13.69 10.08 5 187107 28 50417984
Venous haemorrhage 13.64 10.08 9 187103 206 50417806
Pharyngeal haematoma 13.54 10.08 5 187107 29 50417983
Implantable defibrillator insertion 13.54 10.08 11 187101 350 50417662
Illness 13.49 10.08 46 187066 24494 50393518
Periorbital haematoma 13.48 10.08 15 187097 712 50417300
Haematoma infection 13.48 10.08 13 187099 521 50417491
Prothrombin time shortened 13.45 10.08 23 187089 1644 50416368
Condition aggravated 13.36 10.08 932 186180 296126 50121886
Tremor 13.35 10.08 323 186789 114580 50303432
Restlessness 13.30 10.08 48 187064 25125 50392887
Thrombotic microangiopathy 13.29 10.08 8 187104 8783 50409229
Demyelination 13.27 10.08 3 187109 6023 50411989
Chordae tendinae rupture 13.26 10.08 5 187107 31 50417981
Abdominal compartment syndrome 13.23 10.08 13 187099 533 50417479
Loss of consciousness 13.21 10.08 491 186621 103862 50314150
Catheter site erosion 13.20 10.08 6 187106 63 50417949
Right ventricular enlargement 13.19 10.08 10 187102 287 50417725
Coma 13.18 10.08 289 186823 56590 50361422
Rehabilitation therapy 13.17 10.08 20 187092 1293 50416719
Venous pressure jugular increased 13.17 10.08 13 187099 536 50417476
Terminal state 13.10 10.08 26 187086 2084 50415928
Pyelonephritis 13.10 10.08 22 187090 14967 50403045
Haemorrhagic hepatic cyst 13 10.08 5 187107 33 50417979
Diverticulum intestinal haemorrhagic 12.95 10.08 19 187093 1191 50416821
Squamous cell carcinoma of the oral cavity 12.95 10.08 10 187102 295 50417717
Influenza like illness 12.86 10.08 143 186969 57316 50360696
Bronchopulmonary aspergillosis 12.82 10.08 6 187106 7586 50410426
Haemorrhagic ascites 12.81 10.08 7 187105 112 50417900
Venous thrombosis 12.80 10.08 41 187071 4425 50413587
Injection site pustule 12.80 10.08 6 187106 68 50417944
Blood culture positive 12.76 10.08 40 187072 4268 50413744
Obstructive airways disorder 12.75 10.08 24 187088 15628 50402384
Pulmonary calcification 12.74 10.08 9 187103 231 50417781
Colitis ulcerative 12.74 10.08 27 187085 16827 50401185
Factor V inhibition 12.72 10.08 8 187104 168 50417844
Extrasystoles 12.68 10.08 42 187070 4613 50413399
Application site irritation 12.66 10.08 22 187090 1593 50416419
Irritability 12.63 10.08 58 187054 28368 50389644
Left ventricular failure 12.59 10.08 43 187069 4798 50413214
Colonoscopy 12.56 10.08 20 187092 1347 50416665
Anger 12.56 10.08 14 187098 11319 50406693
Affect lability 12.51 10.08 9 187103 8989 50409023
Lip haemorrhage 12.50 10.08 12 187100 478 50417534
Dry mouth 12.50 10.08 140 186972 56038 50361974
Status epilepticus 12.35 10.08 19 187093 13387 50404625
Grip strength decreased 12.34 10.08 16 187096 12105 50405907
Arteriovenous fistula site haemorrhage 12.32 10.08 8 187104 178 50417834
Cardiac tamponade 12.27 10.08 39 187073 4193 50413819
Schizophrenia 12.25 10.08 6 187106 7391 50410621
Hospice care 12.25 10.08 48 187064 5724 50412288
Poisoning deliberate 12.25 10.08 7 187105 7905 50410107
Transient ischaemic attack 12.24 10.08 177 186935 32033 50385979
Blood blister 12.22 10.08 22 187090 1638 50416374
Renal stone removal 12.18 10.08 7 187105 124 50417888
Wheezing 12.14 10.08 159 186953 61888 50356124
Crying 12.11 10.08 37 187075 20379 50397633
Blood urea increased 12.10 10.08 137 186975 23448 50394564
Pulmonary artery dilatation 12.09 10.08 9 187103 251 50417761
Conjunctivitis 12.09 10.08 26 187086 16119 50401893
Inadequate diet 12.03 10.08 7 187105 127 50417885
Multiple injuries 11.98 10.08 22 187090 1664 50416348
Injection site mass 11.95 10.08 25 187087 15655 50402357
Maternal exposure before pregnancy 11.90 10.08 3 187109 5594 50412418
Bone marrow failure 11.90 10.08 57 187055 27567 50390445
Coagulation time abnormal 11.88 10.08 6 187106 81 50417931
Long QT syndrome congenital 11.87 10.08 5 187107 43 50417969
Incarcerated umbilical hernia 11.85 10.08 4 187108 17 50417995
Bone disorder 11.84 10.08 33 187079 18719 50399293
Duodenal ulcer 11.77 10.08 53 187059 6722 50411290
Large intestinal haemorrhage 11.77 10.08 18 187094 1171 50416841
Heart rate abnormal 11.76 10.08 37 187075 3955 50414057
Iliac artery embolism 11.74 10.08 3 187109 3 50418009
Vascular stenosis 11.70 10.08 9 187103 264 50417748
Subcapsular renal haematoma 11.67 10.08 9 187103 265 50417747
Immune reconstitution inflammatory syndrome 11.65 10.08 3 187109 5513 50412499
Hyperhidrosis 11.63 10.08 247 186865 89179 50328833
Tricuspid valve incompetence 11.61 10.08 84 187028 12686 50405326
Pathological fracture 11.60 10.08 7 187105 7675 50410337
Hypophagia 11.60 10.08 155 186957 27573 50390439
Renal impairment 11.59 10.08 364 186748 75297 50342715
Visual impairment 11.58 10.08 180 186932 68095 50349917
Herpes simplex 11.57 10.08 6 187106 7156 50410856
Occult blood 11.57 10.08 18 187094 1189 50416823
Pelvic haemorrhage 11.57 10.08 7 187105 137 50417875
Blood creatinine increased 11.56 10.08 366 186746 75794 50342218
Urine output decreased 11.55 10.08 72 187040 10349 50407663
Peritonitis 11.54 10.08 25 187087 15461 50402551
Cardiac output increased 11.52 10.08 7 187105 138 50417874
Atrioventricular block 11.50 10.08 51 187061 6427 50411585
Joint effusion 11.48 10.08 19 187093 13002 50405010
Clostridium difficile infection 11.39 10.08 144 186968 25295 50392717
Unintentional medical device removal 11.39 10.08 3 187109 5432 50412580
Cerebellar haematoma 11.38 10.08 10 187102 355 50417657
Metastases to central nervous system 11.38 10.08 15 187097 11267 50406745
Spinal cord haemorrhage 11.37 10.08 8 187104 204 50417808
Prescribed overdose 11.36 10.08 23 187089 14577 50403435
Catheter site mass 11.32 10.08 4 187108 20 50417992
Cardiac resynchronisation therapy 11.32 10.08 4 187108 20 50417992
Hepatic steatosis 11.29 10.08 49 187063 24335 50393677
Infusion site induration 11.27 10.08 15 187097 858 50417154
Heart valve incompetence 11.27 10.08 26 187086 2313 50415699
Colitis microscopic 11.24 10.08 5 187107 6515 50411497
Lymphadenopathy 11.24 10.08 75 187037 33424 50384588
Pre-eclampsia 11.24 10.08 8 187104 8036 50409976
Aspiration pleural cavity 11.22 10.08 14 187098 751 50417261
Sporotrichosis 11.16 10.08 4 187108 21 50417991
Acute generalised exanthematous pustulosis 11.10 10.08 10 187102 8928 50409084
Productive cough 11.05 10.08 264 186848 52430 50365582
Haemorrhage urinary tract 11.02 10.08 14 187098 765 50417247
Tinnitus 11.01 10.08 60 187052 28072 50389940
Hypercreatininaemia 11.01 10.08 10 187102 371 50417641
Peripheral embolism 11.00 10.08 17 187095 1116 50416896
Diabetes mellitus 10.98 10.08 122 186990 48911 50369101
Thyroiditis acute 10.98 10.08 6 187106 96 50417916
Biopsy liver 10.96 10.08 10 187102 373 50417639
Pulmonary arterial wedge pressure increased 10.95 10.08 9 187103 291 50417721
Liver function test increased 10.93 10.08 53 187059 25553 50392459
Embolic stroke 10.93 10.08 33 187079 3451 50414561
Oxygen consumption 10.92 10.08 6 187106 97 50417915
Cardiac output decreased 10.91 10.08 15 187097 885 50417127
Transaminases abnormal 10.88 10.08 12 187100 564 50417448
Uveitis 10.88 10.08 11 187101 9299 50408713
Infective pulmonary exacerbation of cystic fibrosis 10.88 10.08 8 187104 7901 50410111
Arteriovenous fistula operation 10.85 10.08 8 187104 220 50417792
Liver function test abnormal 10.83 10.08 227 186885 44112 50373900
Osteonecrosis of jaw 10.83 10.08 73 187039 32453 50385559
Dermatitis allergic 10.81 10.08 19 187093 12701 50405311
Blood pressure systolic decreased 10.81 10.08 46 187066 5693 50412319
Influenza 10.78 10.08 419 186693 89119 50328893
Metastases to lung 10.76 10.08 15 187097 11005 50407007
Localised oedema 10.76 10.08 41 187071 4826 50413186
Emotional distress 10.75 10.08 62 187050 28601 50389411
Angina pectoris 10.73 10.08 55 187057 26133 50391879
Joint range of motion decreased 10.66 10.08 34 187078 18478 50399534
Malignant melanoma 10.65 10.08 13 187099 10095 50407917
Procedural pain 10.59 10.08 22 187090 13810 50404202
Breast haemorrhage 10.58 10.08 7 187105 161 50417851
Renal haemorrhage 10.57 10.08 14 187098 797 50417215
Incision site haemorrhage 10.56 10.08 11 187101 484 50417528
Diuretic therapy 10.56 10.08 6 187106 104 50417908
Blood pressure orthostatic abnormal 10.54 10.08 3 187109 6 50418006
Oral candidiasis 10.51 10.08 30 187082 16885 50401127
Paraplegia 10.45 10.08 26 187086 2428 50415584
Adnexal torsion 10.39 10.08 8 187104 235 50417777
Nightmare 10.39 10.08 28 187084 16058 50401954
Catheter site hypersensitivity 10.36 10.08 6 187106 108 50417904
Pulmonary pain 10.36 10.08 25 187087 2290 50415722
Premature baby 10.34 10.08 34 187078 18303 50399709
Pulmonary resection 10.32 10.08 4 187108 27 50417985
Aortic surgery 10.32 10.08 4 187108 27 50417985
Photophobia 10.32 10.08 25 187087 14862 50403150
Myoclonus 10.27 10.08 24 187088 14446 50403566
Incorrect route of product administration 10.26 10.08 35 187077 18631 50399381
Right atrial dilatation 10.24 10.08 12 187100 603 50417409
5-hydroxyindolacetic acid increased 10.23 10.08 3 187109 7 50418005
Infusion site discolouration 10.13 10.08 12 187100 610 50417402
Heart transplant 10.12 10.08 10 187102 413 50417599
Vessel puncture site haemorrhage 10.12 10.08 6 187106 113 50417899
Thrombocytopenia 10.09 10.08 378 186734 127295 50290717

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 10690.92 10.68 5089 157401 39283 29372754
Gastric haemorrhage 1962.90 10.68 978 161512 8319 29403718
Haemorrhage 1895.22 10.68 1734 160756 43338 29368699
International normalised ratio abnormal 1738.31 10.68 643 161847 2320 29409717
International normalised ratio decreased 1140.47 10.68 525 161965 3665 29408372
Gastrointestinal haemorrhage 1002.57 10.68 1664 160826 77869 29334168
Anticoagulation drug level above therapeutic 902.70 10.68 350 162140 1481 29410556
Drug interaction 798.05 10.68 2637 159853 194748 29217289
Haematuria 689.62 10.68 1020 161470 43119 29368918
Haematoma 688.05 10.68 739 161751 22473 29389564
Subdural haematoma 651.02 10.68 641 161849 17552 29394485
Melaena 590.13 10.68 790 161700 30386 29381651
Haemorrhage intracranial 568.57 10.68 538 161952 14004 29398033
Epistaxis 492.03 10.68 958 161532 50746 29361291
Anticoagulation drug level below therapeutic 470.21 10.68 167 162323 518 29411519
International normalised ratio fluctuation 444.20 10.68 179 162311 856 29411181
Calciphylaxis 403.44 10.68 166 162324 846 29411191
Labelled drug-drug interaction medication error 354.68 10.68 384 162106 11775 29400262
Cerebral haemorrhage 323.08 10.68 602 161888 30824 29381213
Rectal haemorrhage 313.79 10.68 628 161862 33921 29378116
Febrile neutropenia 307.64 10.68 116 162374 112124 29299913
Anaemia 307.55 10.68 2021 160469 198930 29213107
Haemoglobin decreased 302.67 10.68 1288 161202 107087 29304950
Prothrombin time prolonged 280.75 10.68 292 162198 8540 29403497
Off label use 271.59 10.68 804 161686 299996 29112041
Drug ineffective 253.13 10.68 1083 161407 362087 29049950
Drug abuse 250.19 10.68 65 162425 79818 29332219
Haemoptysis 249.96 10.68 532 161958 30018 29382019
Muscle haemorrhage 241.55 10.68 177 162313 3185 29408852
Coagulopathy 234.83 10.68 382 162108 17525 29394512
Fall 233.10 10.68 1718 160772 175460 29236577
Pyrexia 230.10 10.68 811 161679 286811 29125226
Cardiac failure congestive 229.97 10.68 931 161559 75650 29336387
Subarachnoid haemorrhage 204.07 10.68 259 162231 9433 29402604
Faeces discoloured 201.73 10.68 304 162186 13047 29398990
Upper gastrointestinal haemorrhage 194.92 10.68 395 162095 21519 29390518
Abdominal wall haematoma 192.87 10.68 117 162373 1510 29410527
Retroperitoneal haematoma 180.48 10.68 129 162361 2229 29409808
Cardiac failure 172.19 10.68 876 161614 78411 29333626
Contusion 166.72 10.68 460 162030 30635 29381402
Pulmonary arterial hypertension 163.10 10.68 203 162287 7246 29404791
Neutropenia 161.82 10.68 298 162192 131413 29280624
Subdural haemorrhage 157.22 10.68 128 162362 2707 29409330
Haematocrit decreased 151.31 10.68 425 162065 28597 29383440
Retroperitoneal haemorrhage 148.60 10.68 118 162372 2405 29409632
Ecchymosis 146.98 10.68 177 162313 6103 29405934
Fluid retention 135.79 10.68 358 162132 23202 29388835
Coagulation time prolonged 130.68 10.68 82 162408 1128 29410909
Foetal warfarin syndrome 130.50 10.68 31 162459 0 29412037
Haematemesis 129.72 10.68 362 162128 24264 29387773
Product use in unapproved indication 125.00 10.68 177 162313 86698 29325339
Depression 121.01 10.68 175 162315 84972 29327065
Atrial fibrillation 115.80 10.68 983 161507 104663 29307374
Haemarthrosis 115.74 10.68 107 162383 2699 29409338
Intra-abdominal haematoma 114.89 10.68 75 162415 1109 29410928
Intraventricular haemorrhage 105.01 10.68 103 162387 2803 29409234
Right ventricular failure 101.63 10.68 167 162323 7723 29404314
Thrombosis 100.02 10.68 485 162005 42560 29369477
Lower gastrointestinal haemorrhage 98.01 10.68 168 162322 8045 29403992
Transfusion 96.07 10.68 156 162334 7142 29404895
Pulmonary hypertension 93.56 10.68 269 162221 18339 29393698
Head injury 90.26 10.68 242 162248 15839 29396198
Occult blood positive 88.85 10.68 106 162384 3618 29408419
Intentional overdose 88.18 10.68 51 162439 38477 29373560
Mucosal inflammation 85.87 10.68 33 162457 31562 29380475
Ear haemorrhage 83.86 10.68 54 162436 779 29411258
Leukopenia 81.85 10.68 110 162380 55093 29356944
Spinal epidural haematoma 81.60 10.68 36 162454 224 29411813
Dyspnoea 81.22 10.68 2358 160132 324374 29087663
Shock haemorrhagic 81.17 10.68 169 162321 9382 29402655
Completed suicide 81.17 10.68 241 162249 90005 29322032
Blood loss anaemia 79.41 10.68 143 162347 7123 29404914
Intestinal haematoma 77.72 10.68 25 162465 51 29411986
Malignant neoplasm progression 77.22 10.68 183 162307 73676 29338361
Suicide attempt 75.46 10.68 47 162443 34063 29377974
Gingival bleeding 74.39 10.68 130 162360 6323 29405714
Infusion related reaction 74.05 10.68 79 162411 43807 29368230
Agitation 72.30 10.68 106 162384 51198 29360839
Cerebral mass effect 71.60 10.68 50 162440 831 29411206
Anaphylactic reaction 71.36 10.68 31 162459 27542 29384495
Pulmonary alveolar haemorrhage 70.29 10.68 126 162364 6254 29405783
Foetal exposure during pregnancy 67.83 10.68 52 162438 33815 29378222
Pancytopenia 67.17 10.68 233 162257 82935 29329102
Anticoagulant-related nephropathy 66.06 10.68 18 162472 13 29412024
Deep vein thrombosis 65.95 10.68 540 161950 56859 29355178
Activated partial thromboplastin time prolonged 64.64 10.68 136 162354 7606 29404431
Drug dependence 63.88 10.68 18 162472 20963 29391074
Pain in jaw 62.15 10.68 172 162318 11469 29400568
Haematoma muscle 61.21 10.68 47 162443 910 29411127
Cardiac tamponade 60.90 10.68 99 162391 4536 29407501
Compartment syndrome 60.49 10.68 71 162419 2381 29409656
Dizziness 60.34 10.68 1415 161075 188269 29223768
Haemorrhage subcutaneous 60.01 10.68 66 162424 2059 29409978
Extradural haematoma 59.36 10.68 49 162441 1057 29410980
Oedema 59.05 10.68 403 162087 40080 29371957
Thrombocytopenia 59.00 10.68 466 162024 134357 29277680
Prothrombin time ratio increased 58.99 10.68 23 162467 99 29411938
Intentional product use issue 58.72 10.68 89 162401 42409 29369628
Drug hypersensitivity 58.41 10.68 187 162303 68219 29343818
Skin necrosis 56.52 10.68 100 162390 4912 29407125
Therapeutic product effect incomplete 55.58 10.68 81 162409 39224 29372813
Product use issue 54.93 10.68 126 162364 51318 29360719
Seizure 54.90 10.68 294 162196 92829 29319208
Conjunctival haemorrhage 54.53 10.68 70 162420 2578 29409459
Heparin-induced thrombocytopenia 54.42 10.68 98 162392 4881 29407156
Stomatitis 53.95 10.68 75 162415 37038 29374999
Neutrophil count decreased 53.91 10.68 98 162392 43469 29368568
Cytokine release syndrome 53.75 10.68 5 162485 13114 29398923
Appendicolith 53.64 10.68 80 162410 3400 29408637
Acute myeloid leukaemia 52.49 10.68 13 162477 16500 29395537
Transient ischaemic attack 52.46 10.68 260 162230 23010 29389027
Hypervolaemia 52.31 10.68 213 162277 17332 29394705
COVID-19 52.13 10.68 73 162417 35941 29376096
Oedema peripheral 51.83 10.68 828 161662 102729 29309308
Cerebrovascular accident 51.77 10.68 648 161842 76263 29335774
Toxicity to various agents 51.52 10.68 659 161831 173002 29239035
Aggression 51.48 10.68 72 162418 35469 29376568
Cytomegalovirus infection 51.33 10.68 32 162458 23183 29388854
Cardiac failure chronic 50.99 10.68 111 162379 6356 29405681
Post procedural haemorrhage 50.66 10.68 121 162369 7370 29404667
Arthralgia 50.35 10.68 507 161983 139110 29272927
Haemorrhagic stroke 50.21 10.68 104 162386 5752 29406285
Haemoperitoneum 49.72 10.68 52 162438 1530 29410507
Device alarm issue 49.58 10.68 34 162456 548 29411489
Ventricular tachycardia 49.32 10.68 250 162240 22324 29389713
General physical health deterioration 49.03 10.68 347 162143 102510 29309527
Suicidal ideation 48.64 10.68 72 162418 34644 29377393
Synovitis 47.86 10.68 3 162487 10887 29401150
Catheter site erythema 47.68 10.68 45 162445 1166 29410871
Rheumatoid arthritis 46.70 10.68 65 162425 32087 29379950
Scrotal haematoma 46.44 10.68 18 162472 76 29411961
Asthma 45.69 10.68 72 162418 33777 29378260
Dyspnoea exertional 45.57 10.68 350 162140 36140 29375897
Cerebellar haemorrhage 45.43 10.68 47 162443 1365 29410672
Gastritis erosive 45.33 10.68 95 162395 5298 29406739
Traumatic haematoma 44.64 10.68 34 162456 650 29411387
Pain 44.60 10.68 668 161822 170764 29241273
Rash 44.26 10.68 755 161735 189064 29222973
White blood cell count decreased 43.86 10.68 273 162217 83089 29328948
Gastric ulcer 43.75 10.68 173 162317 13888 29398149
Intentional product misuse 43.75 10.68 77 162413 34584 29377453
Haematochezia 43.58 10.68 350 162140 36633 29375404
Mesenteric haematoma 43.53 10.68 13 162477 18 29412019
Cholestasis 43.31 10.68 39 162451 23423 29388614
Chills 43.18 10.68 223 162267 71077 29340960
Angioedema 42.97 10.68 68 162422 31847 29380190
Rash maculo-papular 42.92 10.68 42 162448 24247 29387790
Catheter management 42.42 10.68 36 162454 808 29411229
Spontaneous haematoma 42.25 10.68 29 162461 468 29411569
Urticaria 42.20 10.68 156 162334 54504 29357533
Hepatocellular injury 42.05 10.68 33 162457 21210 29390827
Gastrointestinal arteriovenous malformation 41.18 10.68 25 162465 323 29411714
Colitis 40.74 10.68 68 162422 31180 29380857
Prothrombin time abnormal 39.84 10.68 29 162461 516 29411521
Pancreatitis 39.77 10.68 81 162409 34433 29377604
Alanine aminotransferase increased 39.60 10.68 228 162262 70716 29341321
Gastric ulcer haemorrhage 39.49 10.68 85 162405 4829 29407208
Drug intolerance 39.40 10.68 135 162355 48244 29363793
Device interaction 39.37 10.68 29 162461 526 29411511
Somnolence 39.12 10.68 329 162161 93626 29318411
Generalised tonic-clonic seizure 38.82 10.68 29 162461 19110 29392927
Cardiac failure acute 38.81 10.68 125 162365 9067 29402970
Lymphopenia 38.70 10.68 13 162477 13520 29398517
Mallory-Weiss syndrome 38.40 10.68 41 162449 1236 29410801
Hyphaema 38.04 10.68 27 162463 461 29411576
Chest wall haematoma 37.99 10.68 18 162472 135 29411902
Mouth haemorrhage 37.64 10.68 82 162408 4698 29407339
Injection site pain 37.51 10.68 76 162414 32370 29379667
Diabetic ketoacidosis 37.16 10.68 21 162469 16052 29395985
Thrombosis in device 36.80 10.68 64 162426 3100 29408937
Hyperhidrosis 36.79 10.68 206 162284 64334 29347703
Hypotension 36.53 10.68 1358 161132 192996 29219041
Aspergillus infection 36.33 10.68 7 162483 10574 29401463
Penile necrosis 36.20 10.68 13 162477 42 29411995
Anxiety 35.95 10.68 298 162192 85067 29326970
Exposure during pregnancy 35.75 10.68 3 162487 8551 29403486
Bone marrow failure 35.54 10.68 60 162430 27389 29384648
Disease progression 35.39 10.68 284 162206 81632 29330405
Atrial flutter 34.76 10.68 160 162330 13734 29398303
Subarachnoid haematoma 34.73 10.68 14 162476 67 29411970
Disturbance in attention 34.55 10.68 40 162450 21384 29390653
Myelosuppression 34.52 10.68 12 162478 12215 29399822
Haematoma evacuation 34.48 10.68 18 162472 170 29411867
Venous pressure jugular increased 34.42 10.68 30 162460 699 29411338
Pelvic haematoma 34.23 10.68 16 162474 116 29411921
Diverticulum intestinal haemorrhagic 34.09 10.68 49 162441 2013 29410024
Pancreatitis acute 33.74 10.68 51 162439 24334 29387703
Hypertension 33.26 10.68 446 162044 116168 29295869
Renal haemorrhage 33.24 10.68 38 162452 1238 29410799
International normalised ratio 33.14 10.68 12 162478 40 29411997
Lymphadenopathy 33.13 10.68 54 162436 24995 29387042
Catheter site haemorrhage 32.89 10.68 48 162442 2000 29410037
Psoriasis 32.75 10.68 81 162409 32146 29379891
Hypercoagulation 32.73 10.68 35 162455 1057 29410980
Subcutaneous haematoma 32.58 10.68 32 162458 872 29411165
Serotonin syndrome 32.45 10.68 29 162461 17483 29394554
Abnormal behaviour 32.36 10.68 48 162442 23079 29388958
Neoplasm progression 31.95 10.68 33 162457 18579 29393458
Psychotic disorder 31.76 10.68 39 162451 20315 29391722
Thalamus haemorrhage 31.76 10.68 32 162458 900 29411137
Bronchopulmonary aspergillosis 31.74 10.68 14 162476 12330 29399707
Cardiogenic shock 31.61 10.68 197 162293 18993 29393044
Cardiac pacemaker insertion 31.29 10.68 52 162438 2427 29409610
Pruritus 30.80 10.68 454 162036 116395 29295642
Therapeutic product effect decreased 30.73 10.68 73 162417 29378 29382659
Internal haemorrhage 30.47 10.68 72 162418 4355 29407682
Catheter site discharge 30.38 10.68 25 162465 537 29411500
Blood urine present 30.33 10.68 120 162370 9635 29402402
Haemophagocytic lymphohistiocytosis 30.19 10.68 10 162480 10494 29401543
Choroidal haemorrhage 30.18 10.68 12 162478 55 29411982
Coma 30.18 10.68 113 162377 39337 29372700
Traumatic intracranial haemorrhage 30.14 10.68 26 162464 597 29411440
Infection 30.06 10.68 273 162217 76478 29335559
Restlessness 29.98 10.68 47 162443 22098 29389939
Hepatic cytolysis 29.79 10.68 5 162485 8342 29403695
Oxygen consumption increased 29.66 10.68 36 162454 1251 29410786
Accidental exposure to product 29.60 10.68 11 162479 10742 29401295
Syncope 29.58 10.68 619 161871 80752 29331285
Atrial thrombosis 29.55 10.68 45 162445 1948 29410089
Tremor 29.49 10.68 260 162230 73278 29338759
Sleep disorder 29.15 10.68 56 162434 24330 29387707
Small intestinal haemorrhage 28.89 10.68 44 162446 1905 29410132
Hypokalaemia 28.73 10.68 160 162330 50043 29361994
Posterior reversible encephalopathy syndrome 28.66 10.68 7 162483 8969 29403068
Anticoagulation drug level decreased 28.57 10.68 12 162478 65 29411972
Extrapyramidal disorder 28.30 10.68 12 162478 10819 29401218
Musculoskeletal stiffness 28.20 10.68 108 162382 37350 29374687
Gamma-glutamyltransferase increased 28.11 10.68 66 162424 26671 29385366
Arteriovenous malformation 27.50 10.68 26 162464 675 29411362
Pericardial haemorrhage 27.45 10.68 54 162436 2877 29409160
Mediastinal haematoma 27.38 10.68 13 162477 98 29411939
Neuroleptic malignant syndrome 27.30 10.68 29 162461 16119 29395918
Aspartate aminotransferase increased 27.22 10.68 204 162286 59521 29352516
Premature baby 27.08 10.68 33 162457 17247 29394790
Tumour lysis syndrome 26.94 10.68 22 162468 13862 29398175
Blue toe syndrome 26.93 10.68 14 162476 131 29411906
Treatment failure 26.85 10.68 108 162382 36831 29375206
C-reactive protein increased 26.47 10.68 139 162351 44124 29367913
Irritability 26.36 10.68 51 162439 22101 29389936
Multiple sclerosis relapse 26.28 10.68 15 162475 11404 29400633
Insomnia 26.20 10.68 337 162153 88424 29323613
Blood pressure fluctuation 26.20 10.68 43 162447 19851 29392186
Hyperbilirubinaemia 26.18 10.68 26 162464 14908 29397129
Lymphocyte count decreased 26.00 10.68 41 162449 19230 29392807
Vomiting 25.90 10.68 930 161560 211330 29200707
Sinusitis 25.88 10.68 99 162391 34251 29377786
Dyskinesia 25.83 10.68 44 162446 20017 29392020
Duodenal ulcer haemorrhage 25.73 10.68 68 162422 4411 29407626
Implant site haematoma 25.68 10.68 11 162479 63 29411974
Hypertriglyceridaemia 25.54 10.68 5 162485 7470 29404567
Food interaction 25.50 10.68 28 162462 872 29411165
Haemorrhagic diathesis 25.45 10.68 49 162441 2569 29409468
Medical device change 25.44 10.68 12 162478 89 29411948
Atheroembolism 25.44 10.68 16 162474 221 29411816
Cardioversion 25.34 10.68 27 162463 812 29411225
Drug resistance 25.28 10.68 50 162440 21490 29390547
Hyperthyroidism 25.26 10.68 104 162386 8504 29403533
Death 25.17 10.68 1582 160908 340502 29071535
Product administration error 24.89 10.68 149 162341 14161 29397876
Asthenia 24.62 10.68 1431 161059 213819 29198218
Cerebral haematoma 24.45 10.68 65 162425 4231 29407806
Pneumonitis 24.39 10.68 76 162414 27968 29384069
Substance abuse 24.36 10.68 4 162486 6783 29405254
Therapeutic product effect increased 24.33 10.68 23 162467 597 29411440
Pneumocystis jirovecii pneumonia 24.29 10.68 34 162456 16745 29395292
Coagulation time shortened 24.05 10.68 15 162475 204 29411833
Colonic haematoma 24.00 10.68 9 162481 34 29412003
Diverticulum 23.97 10.68 83 162407 6249 29405788
Haemorrhoidal haemorrhage 23.89 10.68 52 162438 2977 29409060
Nausea 23.88 10.68 1323 161167 287932 29124105
Hypochromasia 23.87 10.68 17 162473 292 29411745
Peripheral swelling 23.85 10.68 487 162003 63252 29348785
Cerebral artery embolism 23.82 10.68 26 162464 804 29411233
Haemothorax 23.77 10.68 56 162434 3380 29408657
Lung transplant 23.74 10.68 38 162452 1718 29410319
Neutrophil count increased 23.26 10.68 28 162462 14714 29397323
Epilepsy 23.21 10.68 41 162449 18391 29393646
Immune reconstitution inflammatory syndrome 23.19 10.68 7 162483 7795 29404242
Hepatotoxicity 23.18 10.68 39 162451 17828 29394209
Psoriatic arthropathy 23.08 10.68 28 162462 14663 29397374
Embolic stroke 23.05 10.68 57 162433 3549 29408488
Medical device site thrombosis 22.97 10.68 8 162482 23 29412014
Duodenal ulcer 22.83 10.68 106 162384 9132 29402905
Laryngeal haematoma 22.82 10.68 13 162477 148 29411889
Adrenal haemorrhage 22.79 10.68 14 162476 185 29411852
Anger 22.74 10.68 16 162474 10874 29401163
Intentional self-injury 22.65 10.68 21 162469 12440 29399597
Hepatic enzyme increased 22.61 10.68 102 162388 33697 29378340
Haemorrhagic cholecystitis 22.56 10.68 10 162480 63 29411974
Intracardiac thrombus 22.36 10.68 43 162447 2252 29409785
Sinus tachycardia 22.35 10.68 30 162460 15039 29396998
Septic shock 22.17 10.68 228 162262 62332 29349705
Dystonia 22.16 10.68 13 162477 9736 29402301
Hypocoagulable state 22.15 10.68 26 162464 872 29411165
Potentiating drug interaction 22.15 10.68 64 162426 4374 29407663
Hypersensitivity 22.11 10.68 185 162305 52718 29359319
Joint swelling 21.92 10.68 171 162319 49459 29362578
Product dose omission issue 21.88 10.68 385 162105 95998 29316039
Intraocular haematoma 21.85 10.68 7 162483 14 29412023
Aplastic anaemia 21.85 10.68 7 162483 7503 29404534
Pulmonary embolism 21.58 10.68 562 161928 75972 29336065
Catheter site pruritus 21.50 10.68 16 162474 295 29411742
Purpura 21.41 10.68 104 162386 9128 29402909
Depressed mood 21.25 10.68 36 162454 16412 29395625
Hepatic failure 21.14 10.68 95 162395 31417 29380620
Haemorrhagic arteriovenous malformation 20.86 10.68 17 162473 360 29411677
Blood pressure increased 20.76 10.68 283 162207 73520 29338517
Fat embolism 20.71 10.68 13 162477 179 29411858
Infusion site pain 20.60 10.68 48 162442 2877 29409160
Product complaint 20.59 10.68 71 162419 5334 29406703
Encephalitis 20.56 10.68 5 162485 6425 29405612
Spinal subdural haematoma 20.53 10.68 9 162481 55 29411982
Labelled drug-disease interaction medication error 20.53 10.68 11 162479 110 29411927
Cardiac operation 20.50 10.68 45 162445 2591 29409446
Complication associated with device 20.49 10.68 69 162421 5122 29406915
Gravitational oedema 20.48 10.68 20 162470 541 29411496
Hyperkalaemia 20.37 10.68 461 162029 60931 29351106
Intra-abdominal haemorrhage 20.11 10.68 39 162451 2056 29409981
Neuropathy peripheral 20.10 10.68 272 162218 70755 29341282
Drug withdrawal syndrome 20.04 10.68 43 162447 17941 29394096
Cytomegalovirus viraemia 20.04 10.68 5 162485 6315 29405722
Transplant rejection 19.95 10.68 13 162477 9199 29402838
Sedation 19.91 10.68 41 162449 17364 29394673
Apallic syndrome 19.83 10.68 14 162476 237 29411800
Infusion site erythema 19.80 10.68 34 162456 1630 29410407
Catheter site pain 19.74 10.68 28 162462 1136 29410901
Appendicitis 19.71 10.68 98 162392 8681 29403356
Drug reaction with eosinophilia and systemic symptoms 19.62 10.68 83 162407 27909 29384128
Antiphospholipid syndrome 19.47 10.68 17 162473 397 29411640
Withdrawal syndrome 19.43 10.68 19 162471 10973 29401064
Haemobilia 19.42 10.68 15 162475 293 29411744
Large intestinal ulcer haemorrhage 19.38 10.68 10 162480 92 29411945
Herpes zoster 19.32 10.68 92 162398 29960 29382077
Sopor 19.11 10.68 114 162376 10820 29401217
Rash erythematous 19.06 10.68 58 162432 21504 29390533
Hepatic steatosis 19.04 10.68 33 162457 14913 29397124
Hepatitis 19.02 10.68 55 162435 20728 29391309
Injection site reaction 19.02 10.68 20 162470 11168 29400869
Prostate cancer 18.95 10.68 74 162416 25453 29386584
Hypercholesterolaemia 18.94 10.68 8 162482 7230 29404807
Splenic haematoma 18.94 10.68 12 162478 168 29411869
Protein S deficiency 18.93 10.68 10 162480 97 29411940
Hallucination, auditory 18.86 10.68 15 162475 9578 29402459
Neurotoxicity 18.86 10.68 32 162458 14581 29397456
Hypoprothrombinaemia 18.82 10.68 16 162474 360 29411677
Anticoagulation drug level increased 18.77 10.68 18 162472 476 29411561
Pericarditis uraemic 18.73 10.68 6 162484 12 29412025
Mitral valve replacement 18.60 10.68 11 162479 135 29411902
Psychomotor hyperactivity 18.60 10.68 11 162479 8202 29403835
Hepatic rupture 18.55 10.68 7 162483 27 29412010
Acute generalised exanthematous pustulosis 18.53 10.68 4 162486 5579 29406458
Pulmonary endarterectomy 18.51 10.68 9 162481 72 29411965
Radiation proctitis 18.40 10.68 9 162481 73 29411964
Akathisia 18.38 10.68 7 162483 6735 29405302
Paraesthesia 18.36 10.68 198 162292 53647 29358390
Heart valve replacement 18.35 10.68 15 162475 319 29411718
Craniotomy 18.30 10.68 9 162481 74 29411963
Large intestinal haemorrhage 18.21 10.68 31 162459 1476 29410561
Pathogen resistance 18.20 10.68 11 162479 8105 29403932
Hepatitis B 18.12 10.68 4 162486 5493 29406544
Protein C decreased 18.11 10.68 6 162484 14 29412023
Diffuse large B-cell lymphoma 17.99 10.68 6 162484 6270 29405767
Blood cholinesterase decreased 17.93 10.68 10 162480 109 29411928
Congestive hepatopathy 17.80 10.68 33 162457 1681 29410356
Tongue haematoma 17.77 10.68 10 162480 111 29411926
Brain herniation 17.75 10.68 52 162438 3581 29408456
Pharyngeal haematoma 17.72 10.68 8 162482 53 29411984
Chest tube insertion 17.70 10.68 9 162481 80 29411957
Central venous catheterisation 17.69 10.68 25 162465 1011 29411026
Muscle strain 17.68 10.68 51 162439 3482 29408555
Prothrombin level increased 17.55 10.68 11 162479 151 29411886
Paranoia 17.54 10.68 17 162473 9860 29402177
Vitamin K deficiency 17.45 10.68 13 162477 240 29411797
Prothrombin level abnormal 17.42 10.68 9 162481 83 29411954
Nephropathy 17.39 10.68 66 162424 5197 29406840
Renal haematoma 17.35 10.68 17 162473 462 29411575
Mental status changes 17.34 10.68 279 162211 34648 29377389
Catheter site infection 17.32 10.68 36 162454 1996 29410041
Fear 17.30 10.68 16 162474 9488 29402549
Prothrombin time shortened 17.21 10.68 29 162461 1369 29410668
Transplant evaluation 17.17 10.68 17 162473 468 29411569
Hyperglycaemia 17.14 10.68 114 162376 34173 29377864
Catheter placement 17.05 10.68 20 162470 670 29411367
Ventricular hyperkinesia 17.00 10.68 12 162478 203 29411834
Infected skin ulcer 16.92 10.68 29 162461 1388 29410649
Abdominal distension 16.91 10.68 350 162140 45561 29366476
Tracheal calcification 16.84 10.68 4 162486 0 29412037
Therapy partial responder 16.70 10.68 4 162486 5195 29406842
Acute respiratory distress syndrome 16.70 10.68 67 162423 22868 29389169
Blood viscosity decreased 16.67 10.68 8 162482 62 29411975
Weight decreased 16.64 10.68 669 161821 150236 29261801
Hemianopia homonymous 16.62 10.68 20 162470 689 29411348
Gangrene 16.59 10.68 56 162434 4162 29407875
Cardiotoxicity 16.58 10.68 3 162487 4741 29407296
Cardiac ventricular thrombosis 16.54 10.68 23 162467 916 29411121
Alopecia 16.39 10.68 52 162438 19032 29393005
Large intestine polyp 16.31 10.68 75 162415 6434 29405603
Influenza like illness 16.27 10.68 74 162416 24396 29387641
Atrial tachycardia 16.09 10.68 34 162456 1907 29410130
Schizophrenia 16.02 10.68 8 162482 6557 29405480
Bovine tuberculosis 15.99 10.68 9 162481 100 29411937
Sinus node dysfunction 15.96 10.68 51 162439 3683 29408354
Right ventricular diastolic collapse 15.94 10.68 8 162482 69 29411968
Toxic epidermal necrolysis 15.92 10.68 49 162441 18104 29393933
Right atrial enlargement 15.86 10.68 12 162478 227 29411810
Palmar-plantar erythrodysaesthesia syndrome 15.86 10.68 36 162454 14723 29397314
Catheter removal 15.84 10.68 11 162479 181 29411856
Drug ineffective for unapproved indication 15.83 10.68 34 162456 14180 29397857
Haemorrhoids 15.79 10.68 114 162376 11543 29400494
Xanthopsia 15.66 10.68 10 162480 142 29411895
Encephalomalacia 15.65 10.68 20 162470 733 29411304
Sepsis 15.63 10.68 633 161857 142049 29269988
Dry mouth 15.63 10.68 64 162426 21720 29390317
Adrenal insufficiency 15.61 10.68 23 162467 11091 29400946
Implantable defibrillator replacement 15.61 10.68 5 162485 10 29412027
Peptic ulcer 15.59 10.68 39 162451 2446 29409591
Ventricular fibrillation 15.58 10.68 144 162346 15689 29396348
Blood pressure decreased 15.56 10.68 343 162147 45134 29366903
Inflammation 15.55 10.68 68 162422 22660 29389377
Crying 15.54 10.68 5 162485 5346 29406691
Puncture site haematoma 15.43 10.68 10 162480 146 29411891
Anaesthesia 15.42 10.68 7 162483 47 29411990
Hypophagia 15.39 10.68 179 162311 20693 29391344
Hypocalcaemia 15.28 10.68 60 162430 20605 29391432
Obstructive airways disorder 15.28 10.68 23 162467 10993 29401044
Incarcerated hernia 15.25 10.68 10 162480 149 29411888
Medical device site haematoma 15.18 10.68 6 162484 27 29412010
Urinary bladder haemorrhage 15.15 10.68 30 162460 1606 29410431
Adenovirus infection 15.14 10.68 3 162487 4444 29407593
Vascular calcification 15.12 10.68 20 162470 759 29411278
Anal abscess 15.09 10.68 5 162485 5246 29406791
Osteoarthritis 15.08 10.68 50 162440 18053 29393984
Hepatitis C 15.07 10.68 16 162474 8894 29403143
Tongue haemorrhage 15.05 10.68 16 162474 480 29411557
Diabetes mellitus 15.01 10.68 143 162347 39688 29372349
Mouth ulceration 14.97 10.68 21 162469 10334 29401703
Mitral valve thickening 14.95 10.68 14 162476 359 29411678
Hydrocephalus 14.91 10.68 55 162435 4272 29407765
Cerebellar haematoma 14.86 10.68 11 162479 201 29411836
Epstein-Barr virus infection 14.84 10.68 9 162481 6620 29405417
Spinal cord haemorrhage 14.84 10.68 13 162477 305 29411732
Transaminases increased 14.79 10.68 69 162421 22593 29389444
Hyperthermia 14.78 10.68 18 162472 9412 29402625
Muscle rigidity 14.72 10.68 18 162472 9393 29402644
Aortic stenosis 14.70 10.68 51 162439 3843 29408194
Cardiac disorder 14.70 10.68 287 162203 36976 29375061
Gastrointestinal erosion 14.61 10.68 14 162476 370 29411667
Polyneuropathy 14.44 10.68 28 162462 12124 29399913
Pulmonary calcification 14.43 10.68 10 162480 164 29411873
Femoral nerve palsy 14.36 10.68 6 162484 32 29412005
Heart valve operation 14.29 10.68 7 162483 57 29411980
Hepatic haematoma 14.27 10.68 14 162476 381 29411656
Mental disorder 14.26 10.68 31 162459 12874 29399163
Injection site erythema 14.23 10.68 35 162455 13921 29398116
Blood glucose increased 14.23 10.68 233 162257 58751 29353286
Strangury 14.21 10.68 9 162481 126 29411911
Pneumonia fungal 14.16 10.68 7 162483 5770 29406267
Myocarditis 14.13 10.68 24 162466 10932 29401105
Eye haematoma 14.09 10.68 7 162483 59 29411978
Periorbital haematoma 14.06 10.68 13 162477 328 29411709
Incision site haematoma 13.98 10.68 8 162482 92 29411945
Splenic rupture 13.98 10.68 27 162463 1419 29410618
Neutropenic sepsis 13.95 10.68 27 162463 11700 29400337
Aortic bruit 13.93 10.68 10 162480 174 29411863
Gastrointestinal ulcer 13.92 10.68 29 162461 1610 29410427
Hepatic encephalopathy 13.84 10.68 32 162458 13003 29399034
Cardioactive drug level increased 13.75 10.68 29 162461 1624 29410413
Presyncope 13.71 10.68 142 162348 15947 29396090
Arteriovenous fistula site haemorrhage 13.68 10.68 8 162482 96 29411941
N-telopeptide urine increased 13.64 10.68 6 162484 37 29412000
Jugular vein distension 13.63 10.68 17 162473 608 29411429
Device occlusion 13.60 10.68 64 162426 5544 29406493
Parkinsonism 13.55 10.68 12 162478 7266 29404771
Tumour haemorrhage 13.54 10.68 37 162453 2448 29409589
Procedural site reaction 13.50 10.68 10 162480 183 29411854
Erectile dysfunction 13.50 10.68 52 162438 17957 29394080
Gastrointestinal angiodysplasia 13.39 10.68 16 162474 547 29411490
Blood pressure systolic decreased 13.36 10.68 49 162441 3795 29408242
Subdural haematoma evacuation 13.31 10.68 5 162485 19 29412018
Aortic valve replacement 13.31 10.68 18 162472 698 29411339
Catatonia 13.29 10.68 4 162486 4464 29407573
Emotional distress 13.29 10.68 36 162454 13859 29398178
Haemorrhagic infarction 13.27 10.68 14 162476 416 29411621
Infusion site haemorrhage 13.23 10.68 18 162472 702 29411335
Infusion site warmth 13.20 10.68 8 162482 103 29411934
Cardiac valve disease 13.19 10.68 40 162450 2808 29409229
Delusion 13.19 10.68 26 162464 11190 29400847
Incision site haemorrhage 13.19 10.68 15 162475 486 29411551
Euphoric mood 13.17 10.68 5 162485 4820 29407217
Spinal cord haematoma 13.14 10.68 8 162482 104 29411933
Wheezing 13.10 10.68 118 162372 33122 29378915
Vitreous haemorrhage 13.06 10.68 32 162458 1981 29410056
Mean platelet volume increased 12.98 10.68 14 162476 427 29411610
Lipase increased 12.98 10.68 16 162474 8321 29403716
Fistula 12.94 10.68 6 162484 5133 29406904
Panic attack 12.94 10.68 16 162474 8310 29403727
Orthostatic hypotension 12.86 10.68 185 162305 22444 29389593
Cognitive disorder 12.84 10.68 76 162414 23423 29388614
N-terminal prohormone brain natriuretic peptide increased 12.84 10.68 31 162459 1901 29410136
Ulnar nerve palsy 12.83 10.68 4 162486 7 29412030
Conjunctivitis 12.82 10.68 15 162475 7983 29404054
Oesophageal ulcer 12.78 10.68 42 162448 3078 29408959
Encephalopathy 12.77 10.68 109 162381 30934 29381103
No adverse event 12.76 10.68 51 162439 17427 29394610
Concomitant disease progression 12.71 10.68 35 162455 2326 29409711
Vascular pseudoaneurysm 12.66 10.68 31 162459 1918 29410119
Agranulocytosis 12.65 10.68 63 162427 20277 29391760
Klebsiella infection 12.65 10.68 13 162477 7336 29404701
Wrong technique in product usage process 12.64 10.68 111 162379 31317 29380720
Arteriovenous graft site haemorrhage 12.63 10.68 3 162487 0 29412037
Eye infection intraocular 12.63 10.68 3 162487 0 29412037
Vascular fragility 12.63 10.68 3 162487 0 29412037
Epiphyseal disorder 12.63 10.68 3 162487 0 29412037
Muscle spasms 12.61 10.68 267 162223 64815 29347222
Basal cell carcinoma 12.56 10.68 49 162441 16861 29395176
Electrolyte imbalance 12.53 10.68 27 162463 11247 29400790
Oesophageal pain 12.51 10.68 18 162472 740 29411297
Libido decreased 12.51 10.68 4 162486 4294 29407743
Acute coronary syndrome 12.50 10.68 31 162459 12294 29399743
Obesity 12.36 10.68 22 162468 9841 29402196
Acute cutaneous lupus erythematosus 12.34 10.68 7 162483 79 29411958
Femoral artery aneurysm 12.32 10.68 9 162481 161 29411876
Upper airway obstruction 12.24 10.68 16 162474 600 29411437
Burning feet syndrome 12.19 10.68 7 162483 81 29411956
Walking distance test abnormal 12.18 10.68 9 162481 164 29411873
Mood altered 12.18 10.68 16 162474 8095 29403942
Nightmare 12.15 10.68 28 162462 11389 29400648
Paracentesis 12.15 10.68 13 162477 393 29411644
Ankle deformity 12.10 10.68 10 162480 216 29411821
Dissociation 12.06 10.68 22 162468 1107 29410930
Dizziness exertional 12.04 10.68 8 162482 122 29411915
Peripheral sensory neuropathy 12.04 10.68 9 162481 5930 29406107
Elbow operation 11.99 10.68 8 162482 123 29411914
Night sweats 11.92 10.68 42 162448 14890 29397147
Metabolic acidosis 11.85 10.68 141 162349 37521 29374516
Pulmonary haematoma 11.83 10.68 6 162484 53 29411984
Prothrombin level decreased 11.79 10.68 21 162469 1037 29411000
Enterococcal infection 11.72 10.68 17 162473 8251 29403786
Maternal exposure during pregnancy 11.72 10.68 4 162486 4119 29407918
Enteritis 11.70 10.68 12 162478 6779 29405258
Atrial septal defect 11.69 10.68 12 162478 6777 29405260
Erythema 11.67 10.68 321 162169 75285 29336752
Eyelid ptosis 11.67 10.68 7 162483 5179 29406858
Eye haemorrhage 11.65 10.68 46 162444 3690 29408347
Gout 11.58 10.68 143 162347 16768 29395269
Coagulation test abnormal 11.57 10.68 14 162476 485 29411552
Thrombectomy 11.56 10.68 7 162483 90 29411947
Osteonecrosis of jaw 11.54 10.68 49 162441 16461 29395576
Aplasia 11.45 10.68 4 162486 4059 29407978
Catheter site swelling 11.44 10.68 11 162479 292 29411745
Pulmonary arterial pressure increased 11.39 10.68 21 162469 1065 29410972
Ubiquinone decreased 11.36 10.68 4 162486 12 29412025
Procalcitonin 11.36 10.68 4 162486 12 29412025
Coagulation factor V level increased 11.35 10.68 5 162485 31 29412006
Cellulitis 11.32 10.68 331 162159 45509 29366528
Arterial haemorrhage 11.32 10.68 17 162473 727 29411310
Protein-losing gastroenteropathy 11.31 10.68 11 162479 296 29411741
Illness 11.27 10.68 12 162478 6662 29405375
Bradyarrhythmia 11.26 10.68 30 162460 1955 29410082
COVID-19 pneumonia 11.26 10.68 22 162468 9500 29402537
Cardiac ventricular disorder 11.26 10.68 10 162480 239 29411798
Pseudomonas infection 11.24 10.68 27 162463 10825 29401212
Poisoning deliberate 11.22 10.68 9 162481 5722 29406315
Spinal osteoarthritis 11.22 10.68 11 162479 6345 29405692
Left ventricular failure 11.21 10.68 53 162437 4600 29407437
Normocytic anaemia 11.20 10.68 30 162460 1962 29410075
Lichen planus 11.13 10.68 18 162472 821 29411216
Metastatic carcinoid tumour 11.12 10.68 4 162486 13 29412024
Cardioactive drug level above therapeutic 11.12 10.68 6 162484 61 29411976
Cardiac pseudoaneurysm 11.09 10.68 5 162485 33 29412004
Skin laceration 11.08 10.68 101 162389 10961 29401076
Endarterectomy 11.06 10.68 8 162482 141 29411896
Granulocytopenia 11.02 10.68 10 162480 5984 29406053
Tuberculosis 11.00 10.68 14 162476 7182 29404855
Anaphylactic shock 11.00 10.68 37 162453 13299 29398738
Hepatitis cholestatic 10.97 10.68 13 162477 6880 29405157
Wound haemorrhage 10.96 10.68 28 162462 1779 29410258
Hyperammonaemia 10.95 10.68 9 162481 5654 29406383
Antiphospholipid antibodies 10.90 10.68 4 162486 14 29412023
Uveitis 10.84 10.68 10 162480 5937 29406100
Respiratory depression 10.82 10.68 38 162452 13485 29398552
Cor pulmonale 10.78 10.68 16 162474 677 29411360
Tubulointerstitial nephritis 10.77 10.68 55 162435 17588 29394449
Sterile pyuria 10.73 10.68 5 162485 36 29412001
Skin haemorrhage 10.72 10.68 44 162446 3593 29408444
Disorientation 10.69 10.68 107 162383 29408 29382629
Hypogammaglobulinaemia 10.68 10.68 10 162480 5897 29406140

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 17353.25 10.15 8116 295803 71051 64123762
Haemorrhage 2203.87 10.15 2270 301649 77081 64117732
International normalised ratio abnormal 2088.92 10.15 812 303107 4176 64190637
Gastric haemorrhage 1968.96 10.15 1053 302866 12428 64182385
Drug interaction 1752.05 10.15 4669 299250 357414 63837399
International normalised ratio decreased 1662.68 10.15 777 303142 6701 64188112
Gastrointestinal haemorrhage 1465.09 10.15 2401 301518 129911 64064902
Anticoagulation drug level above therapeutic 1397.69 10.15 530 303389 2515 64192298
Haematoma 1135.63 10.15 1240 302679 45010 64149803
Calciphylaxis 1122.53 10.15 463 303456 2849 64191964
Subdural haematoma 1019.57 10.15 931 302988 27123 64167690
Melaena 914.14 10.15 1193 302726 52355 64142458
Drug ineffective 889.90 10.15 1632 302287 838615 63356198
Haematuria 883.27 10.15 1249 302670 59222 64135591
Epistaxis 840.73 10.15 1592 302327 96539 64098274
Pulmonary arterial hypertension 803.32 10.15 780 303139 24587 64170226
Haemorrhage intracranial 770.63 10.15 742 303177 23142 64171671
Labelled drug-drug interaction medication error 669.88 10.15 663 303256 21399 64173414
Fluid retention 640.38 10.15 1068 302851 58538 64136275
Anticoagulation drug level below therapeutic 629.82 10.15 236 303683 1076 64193737
Cerebral haemorrhage 619.21 10.15 967 302952 50123 64144690
Cardiac failure congestive 573.04 10.15 1628 302291 128952 64065861
Haemoglobin decreased 569.92 10.15 2116 301803 192947 64001866
Anaemia 549.87 10.15 3352 300567 375328 63819485
International normalised ratio fluctuation 541.05 10.15 269 303650 2692 64192121
Rectal haemorrhage 523.10 10.15 998 302921 60819 64133994
Off label use 515.38 10.15 1416 302503 631390 63563423
Prothrombin time prolonged 515.26 10.15 493 303426 15248 64179565
Dyspnoea 507.77 10.15 5389 298530 713285 63481528
Coagulopathy 439.05 10.15 641 303278 31279 64163534
Haemoptysis 434.99 10.15 808 303111 48240 64146573
Synovitis 422.72 10.15 9 303910 99081 64095732
Pulmonary hypertension 410.88 10.15 733 303186 42406 64152407
Febrile neutropenia 407.52 10.15 187 303732 187470 64007343
Abdominal wall haematoma 398.26 10.15 250 303669 4055 64190758
Cardiac failure 392.15 10.15 1443 302476 130930 64063883
Muscle haemorrhage 387.05 10.15 274 303645 5479 64189334
Right ventricular failure 368.75 10.15 480 303439 20991 64173822
Atrial fibrillation 368.38 10.15 1690 302229 169399 64025414
Infusion related reaction 366.34 10.15 158 303761 164309 64030504
Pain in jaw 350.91 10.15 663 303256 40092 64154721
Drug intolerance 350.46 10.15 227 303692 187765 64007048
Rheumatoid arthritis 323.49 10.15 186 303733 164108 64030705
Hypervolaemia 316.30 10.15 612 303307 37673 64157140
Catheter site erythema 314.83 10.15 226 303693 4623 64190190
Drug abuse 298.23 10.15 125 303794 132249 64062564
Drug hypersensitivity 297.18 10.15 412 303507 237403 63957410
Transfusion 294.67 10.15 393 303526 17601 64177212
Retroperitoneal haematoma 284.15 10.15 210 303709 4501 64190312
Upper gastrointestinal haemorrhage 283.64 10.15 557 303362 34663 64160150
Arthralgia 280.13 10.15 1104 302815 441156 63753657
Pemphigus 269.48 10.15 3 303916 60698 64134115
Ecchymosis 268.55 10.15 331 303588 13691 64181122
Joint swelling 267.21 10.15 375 303544 215007 63979806
Dyspnoea exertional 265.55 10.15 858 303061 72872 64121941
Faeces discoloured 256.36 10.15 446 303473 25283 64169530
Fall 254.41 10.15 3041 300878 413785 63781028
Therapeutic product effect decreased 253.35 10.15 113 303806 115238 64079575
Neutropenia 252.32 10.15 465 303454 239159 63955654
Subarachnoid haemorrhage 251.68 10.15 369 303550 18069 64176744
Alopecia 246.51 10.15 250 303669 165440 64029373
Subdural haemorrhage 241.02 10.15 200 303719 5103 64189710
Thrombosis 222.55 10.15 786 303133 69856 64124957
Pain 221.19 10.15 1614 302305 551897 63642916
Catheter site pain 221.15 10.15 177 303742 4285 64190528
Catheter management 219.26 10.15 157 303762 3198 64191615
Treatment failure 216.32 10.15 142 303777 116674 64078139
Coagulation time prolonged 212.13 10.15 130 303789 2016 64192797
Product use in unapproved indication 209.70 10.15 317 303602 176301 64018512
Device related infection 209.67 10.15 453 303466 30173 64164640
Retroperitoneal haemorrhage 205.61 10.15 176 303743 4692 64190121
Oedema peripheral 203.87 10.15 1690 302229 208627 63986186
Hypersensitivity 198.18 10.15 391 303528 196061 63998752
Hand deformity 194.97 10.15 31 303888 62740 64132073
Catheter site discharge 194.49 10.15 125 303794 2116 64192697
Completed suicide 193.39 10.15 487 303432 223927 63970886
Musculoskeletal stiffness 192.39 10.15 178 303741 123028 64071785
Pyrexia 192.23 10.15 1696 302223 556948 63637865
Stomatitis 191.35 10.15 142 303777 109463 64085350
Oedema 188.71 10.15 896 303023 91039 64103774
Haematemesis 183.95 10.15 563 303356 46436 64148377
Contraindicated product administered 181.49 10.15 145 303774 107684 64087129
Haematocrit decreased 180.70 10.15 618 303301 54037 64140776
Rash 179.69 10.15 1344 302575 457205 63737608
Heparin-induced thrombocytopenia 176.82 10.15 209 303710 8270 64186543
Lower gastrointestinal haemorrhage 173.20 10.15 267 303652 13672 64181141
Haemarthrosis 171.54 10.15 164 303755 5065 64189748
Arthropathy 171.50 10.15 190 303729 120777 64074036
Pericarditis 170.87 10.15 42 303877 62474 64132339
Glossodynia 170.08 10.15 47 303872 64649 64130164
Syncope 169.81 10.15 1298 302621 156337 64038476
Intra-abdominal haematoma 168.92 10.15 119 303800 2360 64192453
Catheter site pruritus 167.37 10.15 112 303807 2036 64192777
Intraventricular haemorrhage 165.00 10.15 145 303774 4008 64190805
Depression 164.77 10.15 389 303530 182902 64011911
Hepatic enzyme increased 161.29 10.15 226 303693 129717 64065096
Central venous catheterisation 158.20 10.15 119 303800 2622 64192191
Catheter site infection 154.38 10.15 161 303758 5532 64189281
Shock haemorrhagic 154.33 10.15 281 303638 16510 64178303
Intentional overdose 153.82 10.15 119 303800 89825 64104988
Therapeutic product effect incomplete 151.74 10.15 158 303761 103324 64091489
Device alarm issue 150.77 10.15 100 303819 1790 64193023
Catheter site haemorrhage 150.62 10.15 144 303775 4447 64190366
Hypotension 150.48 10.15 2576 301343 378398 63816415
Skin necrosis 150.11 10.15 254 303665 14075 64180738
Product use issue 143.64 10.15 313 303606 151402 64043411
Injection site pain 143.07 10.15 189 303730 111219 64083594
Mucosal inflammation 142.67 10.15 58 303861 62526 64132287
Leukopenia 142.43 10.15 160 303759 101082 64093731
Blood loss anaemia 138.62 10.15 241 303678 13651 64181162
Head injury 132.81 10.15 398 303521 32444 64162369
Malignant neoplasm progression 131.59 10.15 205 303714 112666 64082147
Infusion site pain 126.17 10.15 197 303722 10200 64184613
Thrombosis in device 126.16 10.15 137 303782 4934 64189879
Exposure during pregnancy 123.88 10.15 110 303809 77565 64117248
Systemic lupus erythematosus 123.67 10.15 110 303809 77502 64117311
Spinal epidural haematoma 119.62 10.15 74 303845 1168 64193645
Catheter placement 118.27 10.15 98 303821 2495 64192318
Sinusitis 117.78 10.15 327 303592 145601 64049212
Deep vein thrombosis 116.52 10.15 872 303047 104310 64090503
Pruritus 115.91 10.15 929 302990 311471 63883342
Urticaria 115.30 10.15 335 303584 146982 64047831
Occult blood positive 114.93 10.15 145 303774 6142 64188671
Duodenal ulcer perforation 114.81 10.15 14 303905 34611 64160202
Anaphylactic reaction 114.69 10.15 93 303826 68571 64126242
Catheter site swelling 112.82 10.15 79 303840 1551 64193262
Folliculitis 110.76 10.15 8 303911 30069 64164744
Dizziness 109.79 10.15 2727 301192 427436 63767377
Injection site erythema 109.65 10.15 103 303816 70697 64124116
Maternal exposure during pregnancy 109.06 10.15 177 303742 95707 64099106
Discomfort 108.19 10.15 133 303786 80745 64114068
Intestinal haematoma 107.59 10.15 37 303882 124 64194689
Injection site reaction 106.76 10.15 43 303876 46621 64148192
Activated partial thromboplastin time prolonged 103.37 10.15 203 303716 12628 64182185
Helicobacter infection 102.47 10.15 27 303892 38335 64156478
Suicidal ideation 101.65 10.15 98 303821 66444 64128369
Haematoma muscle 101.61 10.15 77 303842 1716 64193097
Contusion 101.45 10.15 899 303020 113066 64081747
Haemoperitoneum 101.32 10.15 108 303811 3807 64191006
Toxicity to various agents 100.10 10.15 1163 302756 362350 63832463
Hypertension 99.85 10.15 763 303156 258498 63936315
Sleep disorder due to general medical condition, insomnia type 99.65 10.15 6 303913 26264 64168549
Pancytopenia 99.44 10.15 344 303575 142965 64051848
Post procedural haemorrhage 99.34 10.15 196 303723 12235 64182578
Haemorrhage subcutaneous 98.48 10.15 112 303807 4249 64190564
Haemorrhagic stroke 98.46 10.15 172 303747 9779 64185034
Device leakage 98.05 10.15 155 303764 8111 64186702
Cardiac pacemaker insertion 96.87 10.15 119 303800 4904 64189909
Hospitalisation 96.40 10.15 646 303273 74561 64120252
General physical health deterioration 94.97 10.15 569 303350 203856 63990957
Cerebrovascular accident 94.93 10.15 1029 302890 136554 64058259
Complication associated with device 94.13 10.15 215 303704 14865 64179948
Anticoagulant-related nephropathy 93.92 10.15 25 303894 21 64194792
Psoriasis 92.69 10.15 121 303798 71582 64123231
Psoriatic arthropathy 92.50 10.15 44 303875 43237 64151576
Spontaneous haematoma 91.25 10.15 63 303856 1208 64193605
Wound 89.98 10.15 138 303781 76339 64118474
Cerebral mass effect 89.54 10.15 70 303849 1636 64193177
Gingival bleeding 87.48 10.15 207 303712 14647 64180166
Suicide attempt 86.59 10.15 125 303794 70882 64123931
Irritable bowel syndrome 86.20 10.15 34 303885 37335 64157478
Infusion site infection 85.47 10.15 66 303853 1514 64193299
Intentional product use issue 84.36 10.15 204 303715 95160 64099653
Lung transplant 83.58 10.15 100 303819 4008 64190805
Infection 83.04 10.15 520 303399 184360 64010453
Drug dependence 82.47 10.15 27 303892 33285 64161528
Extradural haematoma 82.28 10.15 81 303838 2595 64192218
Multiple sclerosis relapse 81.70 10.15 46 303873 41089 64153724
Presyncope 81.66 10.15 355 303564 34734 64160079
Injection site pruritus 81.54 10.15 38 303881 37788 64157025
Anxiety 81.04 10.15 590 303329 202059 63992754
Pulmonary alveolar haemorrhage 80.80 10.15 156 303763 9582 64185231
Paraesthesia 80.37 10.15 343 303576 134179 64060634
Muscle injury 79.99 10.15 14 303905 26423 64168390
Asthma 79.35 10.15 210 303709 95015 64099798
Atrial flutter 78.48 10.15 235 303684 19145 64175668
Catheter site inflammation 77.81 10.15 51 303868 894 64193919
Traumatic haematoma 77.60 10.15 68 303851 1872 64192941
Neutrophil count decreased 77.46 10.15 154 303765 77042 64117771
Seizure 77.25 10.15 465 303454 166427 64028386
Ear haemorrhage 74.39 10.15 66 303853 1848 64192965
Subcutaneous haematoma 74.20 10.15 74 303845 2409 64192404
Cerebellar haemorrhage 74.07 10.15 76 303843 2561 64192252
Blood cholesterol increased 73.87 10.15 76 303843 49990 64144823
Sleep disorder 72.91 10.15 105 303814 59604 64135209
Coagulation test abnormal 72.29 10.15 52 303867 1067 64193746
Hypocoagulable state 72.22 10.15 64 303855 1789 64193024
Infusion site erythema 72.21 10.15 122 303797 6751 64188062
Ventricular tachycardia 71.02 10.15 335 303584 33930 64160883
Osteoarthritis 71.00 10.15 118 303801 63218 64131595
Intra-abdominal haemorrhage 70.58 10.15 91 303828 3940 64190873
Cardiac failure chronic 70.38 10.15 141 303778 8900 64185913
Generalised tonic-clonic seizure 70.36 10.15 51 303868 39806 64155007
Cytokine release syndrome 70.10 10.15 8 303911 20821 64173992
Internal haemorrhage 70.06 10.15 128 303791 7539 64187274
Prothrombin time ratio increased 69.72 10.15 30 303889 208 64194605
Bradycardia 69.38 10.15 857 303062 117362 64077451
Acute myeloid leukaemia 68.44 10.15 22 303897 27441 64167372
Asthenia 68.04 10.15 2561 301358 425483 63769330
Choroidal haemorrhage 67.94 10.15 26 303893 127 64194686
C-reactive protein increased 67.73 10.15 225 303694 94684 64100129
Prothrombin time abnormal 67.53 10.15 45 303874 812 64194001
Device occlusion 67.11 10.15 146 303773 9767 64185046
Serotonin syndrome 67.11 10.15 52 303867 39230 64155583
Compartment syndrome 67.09 10.15 91 303828 4141 64190672
Inflammation 66.61 10.15 129 303790 65171 64129642
Injection site swelling 66.60 10.15 58 303861 41295 64153518
Catheter site rash 65.17 10.15 46 303873 915 64193898
Haematochezia 65.05 10.15 535 303384 65838 64128975
Palpitations 65.04 10.15 766 303153 103722 64091091
Conjunctival haemorrhage 64.95 10.15 98 303821 4923 64189890
COVID-19 64.45 10.15 131 303788 65009 64129804
Cardiac tamponade 64.36 10.15 128 303791 8036 64186777
Pericardial haemorrhage 64.16 10.15 88 303831 4048 64190765
Angioedema 64.04 10.15 121 303798 61700 64133113
Nasal congestion 64.01 10.15 491 303428 59167 64135646
Appendicolith 63.40 10.15 80 303839 3389 64191424
Loss of personal independence in daily activities 63.28 10.15 156 303763 72298 64122515
Cardiac disorder 63.06 10.15 465 303454 55351 64139462
Cardiac operation 62.88 10.15 88 303831 4126 64190687
White blood cell count decreased 62.86 10.15 460 303459 157377 64037436
Pulmonary endarterectomy 62.77 10.15 27 303892 187 64194626
Hypercoagulation 62.02 10.15 69 303850 2554 64192259
Food interaction 61.91 10.15 53 303866 1413 64193400
Cardioactive drug level increased 61.89 10.15 79 303840 3386 64191427
Chest pain 61.83 10.15 1502 302417 234478 63960335
Potentiating drug interaction 61.77 10.15 123 303796 7729 64187084
Haematoma evacuation 61.76 10.15 30 303889 284 64194529
Lower respiratory tract infection 61.71 10.15 233 303686 94381 64100432
Dystonia 61.64 10.15 8 303911 18857 64175956
Hypoaesthesia 61.55 10.15 393 303526 138715 64056098
Oxygen consumption increased 61.53 10.15 91 303828 4490 64190323
Wrong technique in product usage process 61.49 10.15 134 303785 64840 64129973
Myelosuppression 61.35 10.15 18 303901 23812 64171001
Cardiac failure acute 61.35 10.15 193 303726 16151 64178662
Blood pressure fluctuation 60.63 10.15 94 303825 51777 64143036
Blood pressure decreased 60.03 10.15 646 303273 85553 64109260
Pulmonary arterial pressure increased 60.00 10.15 85 303834 4031 64190782
Cytomegalovirus infection 58.91 10.15 53 303866 37146 64157667
Device expulsion 58.14 10.15 14 303905 21122 64173691
Cardiac valve replacement complication 58.03 10.15 26 303893 201 64194612
Pelvic haematoma 58.03 10.15 38 303881 665 64194148
International normalised ratio 58.01 10.15 21 303898 85 64194728
Death 58.01 10.15 2805 301114 479900 63714913
Impaired healing 57.82 10.15 124 303795 60349 64134464
Blood pressure increased 57.69 10.15 527 303392 172025 64022788
Accidental exposure to product 57.58 10.15 26 303893 26338 64168475
Device related sepsis 57.50 10.15 94 303825 5061 64189752
Medical device change 57.33 10.15 33 303886 453 64194360
Agitation 56.73 10.15 219 303700 88148 64106665
Pulmonary embolism 56.63 10.15 987 302932 145369 64049444
Ill-defined disorder 56.25 10.15 75 303844 43977 64150836
Arthritis 55.57 10.15 205 303714 83609 64111204
Gastrointestinal arteriovenous malformation 55.50 10.15 41 303878 878 64193935
Thrombocytopenia 55.48 10.15 732 303187 223069 63971744
Atrial thrombosis 55.35 10.15 70 303849 2972 64191841
Fibromyalgia 55.29 10.15 52 303867 35679 64159134
Insomnia 55.11 10.15 631 303288 197205 63997608
Dialysis 54.75 10.15 190 303729 16730 64178083
Colitis 54.71 10.15 122 303797 58552 64136261
Flushing 54.57 10.15 589 303330 78059 64116754
Catheterisation cardiac 54.55 10.15 89 303830 4784 64190029
Blister 54.37 10.15 197 303722 80770 64114043
Gout 53.98 10.15 222 303697 21191 64173622
Hepatocellular injury 53.81 10.15 81 303838 45154 64149659
Gastritis erosive 53.59 10.15 131 303788 9464 64185349
Mediastinal haematoma 53.52 10.15 24 303895 186 64194627
Oxygen saturation decreased 53.32 10.15 754 303165 106422 64088391
Anticoagulation drug level decreased 53.22 10.15 21 303898 113 64194700
Intentional self-injury 52.80 10.15 36 303883 29008 64165805
Adrenal haemorrhage 52.79 10.15 33 303886 531 64194282
Psychotic disorder 52.72 10.15 51 303868 34527 64160286
Cardiogenic shock 52.56 10.15 296 303623 32131 64162682
Hyperkalaemia 52.56 10.15 717 303202 100412 64094401
Cerebral haematoma 52.31 10.15 109 303810 7076 64187737
Transplant evaluation 51.39 10.15 49 303870 1508 64193305
Disturbance in attention 51.37 10.15 71 303848 41003 64153810
Red blood cell sedimentation rate increased 51.29 10.15 43 303876 31192 64163621
Haemothorax 50.94 10.15 86 303833 4756 64190057
Protein C decreased 50.83 10.15 17 303902 51 64194762
Vascular pseudoaneurysm 50.78 10.15 68 303851 3056 64191757
Hyphaema 50.67 10.15 34 303885 621 64194192
Cardioversion 50.56 10.15 53 303866 1832 64192981
Scrotal haematoma 50.49 10.15 18 303901 69 64194744
Intentional product misuse 50.48 10.15 173 303746 72122 64122691
Aggression 50.11 10.15 88 303831 46144 64148669
Mesenteric haematoma 50.02 10.15 14 303905 17 64194796
Gangrene 49.59 10.15 108 303811 7230 64187583
Foot deformity 49.37 10.15 9 303910 16495 64178318
Neoplasm progression 49.07 10.15 73 303846 40891 64153922
Hepatotoxicity 49.06 10.15 70 303849 39892 64154921
Herpes zoster 47.84 10.15 201 303718 78986 64115827
Haemophagocytic lymphohistiocytosis 47.78 10.15 12 303907 17597 64177216
Rheumatoid nodule 47.65 10.15 3 303916 12648 64182165
Sedation 47.64 10.15 76 303843 41386 64153427
Cognitive disorder 47.02 10.15 120 303799 54967 64139846
Bone marrow failure 46.95 10.15 97 303822 47855 64146958
Gastrointestinal disorder 46.91 10.15 240 303679 89469 64105344
Subarachnoid haematoma 46.53 10.15 18 303901 91 64194722
Lymphocyte count decreased 46.38 10.15 75 303844 40624 64154189
Lymphopenia 46.38 10.15 32 303887 25625 64169188
Spinal subdural haematoma 46.34 10.15 22 303897 197 64194616
Brain herniation 46.27 10.15 98 303821 6435 64188378
Tongue haematoma 46.15 10.15 22 303897 199 64194614
Venous pressure jugular increased 46.02 10.15 42 303877 1221 64193592
Pulmonary thrombosis 45.90 10.15 131 303788 10387 64184426
Diverticulum intestinal haemorrhagic 45.44 10.15 66 303853 3203 64191610
Atrial tachycardia 45.38 10.15 69 303850 3490 64191323
Arteriovenous malformation 45.32 10.15 46 303873 1530 64193283
Gastric ulcer haemorrhage 45.29 10.15 111 303808 8032 64186781
Oral herpes 45.11 10.15 24 303895 22128 64172685
Congestive hepatopathy 45.07 10.15 73 303846 3900 64190913
Mouth haemorrhage 44.52 10.15 124 303795 9695 64185118
Diabetic ketoacidosis 44.37 10.15 45 303874 29800 64165013
Therapy change 43.83 10.15 95 303824 6339 64188474
Tremor 43.56 10.15 467 303452 147763 64047050
Type 2 diabetes mellitus 43.36 10.15 58 303861 33962 64160851
Abdominal discomfort 43.12 10.15 602 303317 181720 64013093
Bronchopulmonary aspergillosis 42.98 10.15 18 303901 19067 64175746
Transient ischaemic attack 42.68 10.15 355 303564 43827 64150986
Pulmonary oedema 42.61 10.15 562 303357 78112 64116701
Traumatic intracranial haemorrhage 42.52 10.15 37 303882 1009 64193804
Eye haemorrhage 42.36 10.15 110 303809 8250 64186563
Coagulation time shortened 42.34 10.15 25 303894 361 64194452
Spinal cord haematoma 42.00 10.15 23 303896 285 64194528
Basal cell carcinoma 41.98 10.15 50 303869 30788 64164025
Pneumocystis jirovecii pneumonia 41.85 10.15 41 303878 27593 64167220
Antiphospholipid syndrome 41.57 10.15 44 303875 1538 64193275
Neuroleptic malignant syndrome 41.55 10.15 34 303885 24962 64169851
Febrile bone marrow aplasia 41.42 10.15 3 303916 11252 64183561
Medical device site thrombosis 41.01 10.15 13 303906 31 64194782
Duodenal ulcer 40.70 10.15 155 303764 14280 64180533
Heart valve replacement 40.67 10.15 31 303888 697 64194116
Catheter removal 40.50 10.15 28 303891 538 64194275
Vitamin K deficiency 40.35 10.15 30 303889 649 64194164
Therapeutic product effect increased 40.16 10.15 40 303879 1300 64193513
Infusion site haemorrhage 40.12 10.15 52 303867 2263 64192550
Neurotoxicity 39.97 10.15 42 303877 27362 64167451
Pulmonary haemorrhage 39.66 10.15 144 303775 12965 64181848
Device connection issue 39.63 10.15 33 303886 846 64193967
Lymphadenopathy 39.61 10.15 102 303817 46584 64148229
Penile necrosis 39.37 10.15 13 303906 37 64194776
Duodenal ulcer haemorrhage 39.28 10.15 90 303829 6235 64188578
Cellulitis 39.28 10.15 640 303279 93017 64101796
Foetal warfarin syndrome 39.26 10.15 9 303910 0 64194813
Neuropathy peripheral 39.24 10.15 359 303560 117166 64077647
Cardiac ablation 39.15 10.15 45 303874 1727 64193086
Rash maculo-papular 38.94 10.15 104 303815 46922 64147891
Abdominal distension 38.79 10.15 652 303267 95342 64099471
Acute kidney injury 38.75 10.15 2533 301386 446707 63748106
Mallory-Weiss syndrome 38.63 10.15 54 303865 2529 64192284
Restlessness 38.52 10.15 81 303838 39704 64155109
Pancreatitis acute 38.42 10.15 91 303828 42764 64152049
Therapeutic response decreased 38.42 10.15 122 303797 52066 64142747
Tendonitis 38.41 10.15 24 303895 20258 64174555
Osteoporosis 38.01 10.15 89 303830 41991 64152822
Sinus tachycardia 37.93 10.15 58 303861 32130 64162683
Palmar-plantar erythrodysaesthesia syndrome 37.89 10.15 48 303871 28771 64166042
Drug resistance 37.87 10.15 67 303852 35035 64159778
Blue toe syndrome 37.66 10.15 27 303892 551 64194262
Dizziness postural 37.38 10.15 116 303803 9636 64185177
Chest wall haematoma 37.34 10.15 23 303896 360 64194453
Renal haemorrhage 37.19 10.15 46 303873 1909 64192904
Muscle spasticity 37.09 10.15 16 303903 16653 64178160
Intracardiac thrombus 36.95 10.15 65 303854 3716 64191097
Hypoprothrombinaemia 36.65 10.15 29 303890 690 64194123
Aphthous ulcer 36.59 10.15 8 303911 12898 64181915
Graft versus host disease 36.36 10.15 10 303909 13803 64181010
Infective pulmonary exacerbation of cystic fibrosis 36.23 10.15 6 303913 11790 64183023
Brain natriuretic peptide increased 36.21 10.15 98 303821 7535 64187278
Aspergillus infection 36.01 10.15 16 303903 16363 64178450
Anticoagulation drug level increased 35.94 10.15 28 303891 651 64194162
Hypokalaemia 35.83 10.15 384 303535 121519 64073294
Embolic stroke 35.76 10.15 90 303829 6621 64188192
Hyperhidrosis 35.72 10.15 396 303523 124524 64070289
Anticoagulation drug level abnormal 35.68 10.15 11 303908 23 64194790
Pancreatitis 35.57 10.15 152 303767 59455 64135358
Dry eye 35.45 10.15 51 303868 28968 64165845
Hypercholesterolaemia 35.43 10.15 14 303905 15359 64179454
Drug monitoring procedure not performed 35.29 10.15 30 303889 792 64194021
Aortic valve replacement 35.23 10.15 35 303884 1134 64193679
Emotional distress 35.20 10.15 73 303846 35965 64158848
Product administration error 35.14 10.15 237 303682 27406 64167407
Immunodeficiency 35.06 10.15 16 303903 16108 64178705
Diverticulum 35.00 10.15 139 303780 13059 64181754
Aplastic anaemia 34.96 10.15 11 303908 13909 64180904
Prosthetic cardiac valve thrombosis 34.94 10.15 12 303907 40 64194773
Tracheal calcification 34.90 10.15 8 303911 0 64194813
Dermatitis contact 34.44 10.15 107 303812 8893 64185920
Catheter site related reaction 34.32 10.15 32 303887 957 64193856
Dry mouth 34.28 10.15 157 303762 60261 64134552
Emergency care 34.12 10.15 31 303888 896 64193917
Vascular device infection 34.11 10.15 84 303835 6096 64188717
Hepatitis 33.95 10.15 106 303813 45476 64149337
Thalamus haemorrhage 33.91 10.15 40 303879 1579 64193234
Catheter site discolouration 33.81 10.15 15 303904 113 64194700
Posterior reversible encephalopathy syndrome 33.65 10.15 35 303884 22911 64171902
Hydrocephalus 33.57 10.15 95 303824 7496 64187317
Vascular pseudoaneurysm ruptured 33.45 10.15 16 303903 146 64194667
Concomitant disease progression 32.99 10.15 57 303862 3212 64191601
Immune reconstitution inflammatory syndrome 32.88 10.15 9 303910 12461 64182352
Haemorrhagic diathesis 32.64 10.15 77 303842 5437 64189376
Prothrombin consumption time prolonged 32.41 10.15 11 303908 35 64194778
Cholestasis 32.26 10.15 106 303813 44766 64150047
Conjunctivitis 32.23 10.15 29 303890 20325 64174488
Atheroembolism 32.19 10.15 18 303901 233 64194580
Bradyarrhythmia 32.16 10.15 61 303858 3697 64191116
Anaphylactic shock 31.72 10.15 59 303860 30269 64164544
Catheter site irritation 31.70 10.15 24 303895 534 64194279
Mouth ulceration 31.45 10.15 66 303853 32378 64162435
Device infusion issue 31.27 10.15 40 303879 1718 64193095
Bursitis 31.25 10.15 33 303886 21452 64173361
Hypophagia 30.55 10.15 303 303616 39284 64155529
Acute generalised exanthematous pustulosis 30.49 10.15 14 303905 14044 64180769
Aortic stenosis 30.47 10.15 82 303837 6283 64188530
Abnormal behaviour 30.45 10.15 71 303848 33551 64161262
Gastric ulcer 30.31 10.15 245 303674 29989 64164824
Mineral supplementation 30.31 10.15 27 303892 760 64194053
Endarterectomy 30.27 10.15 19 303900 308 64194505
Laryngeal haematoma 30.17 10.15 15 303904 150 64194663
Cytomegalovirus viraemia 30.12 10.15 7 303912 10821 64183992
Drug reaction with eosinophilia and systemic symptoms 30.10 10.15 142 303777 54075 64140738
Wheezing 30.09 10.15 239 303680 80340 64114473
Catheter culture positive 30.03 10.15 16 303903 187 64194626
Sinus node dysfunction 29.76 10.15 85 303834 6743 64188070
Fatigue 29.52 10.15 3084 300835 745646 63449167
Chills 29.40 10.15 462 303457 136802 64058011
Atrial septal defect repair 29.31 10.15 20 303899 376 64194437
Pregnancy 29.30 10.15 33 303886 20832 64173981
Encephalopathy 29.27 10.15 160 303759 58659 64136154
Mitral valve replacement 29.19 10.15 19 303900 329 64194484
Large intestinal haemorrhage 29.16 10.15 47 303872 2500 64192313
Irritability 29.13 10.15 83 303836 36663 64158150
Pneumonitis 29.10 10.15 130 303789 50235 64144578
Crying 29.06 10.15 31 303888 20059 64174754
Orthopnoea 29.06 10.15 102 303817 9032 64185781
Central venous catheter removal 28.72 10.15 20 303899 389 64194424
Colonic haematoma 28.67 10.15 12 303907 77 64194736
Osteopenia 28.60 10.15 19 303900 15521 64179292
Oxygen therapy 28.59 10.15 44 303875 2249 64192564
Myocarditis 28.55 10.15 23 303896 17020 64177793
Infusion site warmth 28.50 10.15 30 303889 1042 64193771
Protein S deficiency 28.42 10.15 14 303905 137 64194676
Drug withdrawal syndrome 28.40 10.15 66 303853 31225 64163588
Tuberculosis 28.25 10.15 13 303906 13025 64181788
Diffuse large B-cell lymphoma 28.23 10.15 7 303912 10354 64184459
Inappropriate schedule of product administration 28.22 10.15 288 303631 91998 64102815
Dizziness exertional 28.22 10.15 21 303898 455 64194358
Withdrawal syndrome 28 10.15 42 303877 23450 64171363
Drug ineffective for unapproved indication 27.99 10.15 66 303853 31067 64163746
Hypertriglyceridaemia 27.88 10.15 9 303910 11196 64183617
Diabetes mellitus 27.77 10.15 191 303728 66283 64128530
Haemorrhoidal haemorrhage 27.70 10.15 74 303845 5645 64189168
Drug-induced liver injury 27.51 10.15 123 303796 47520 64147293
Extrapyramidal disorder 27.37 10.15 31 303888 19521 64175292
Osteonecrosis of jaw 27.33 10.15 96 303823 39729 64155084
Periorbital haematoma 27.32 10.15 27 303892 869 64193944
Myxoedema coma 27.32 10.15 24 303895 663 64194150
Skin weeping 27.25 10.15 23 303896 601 64194212
Vascular calcification 27.04 10.15 28 303891 954 64193859
Device interaction 26.99 10.15 24 303895 674 64194139
Joint stiffness 26.91 10.15 65 303854 30339 64164474
Blood urine present 26.86 10.15 163 303756 18177 64176636
Injection site warmth 26.81 10.15 15 303904 13447 64181366
Chest tube insertion 26.77 10.15 13 303906 123 64194690
Night sweats 26.72 10.15 84 303835 35962 64158851
Injection site rash 26.68 10.15 21 303898 15721 64179092
Gravitational oedema 26.58 10.15 36 303883 1636 64193177
Infusion site irritation 26.53 10.15 20 303899 442 64194371
Breast necrosis 26.49 10.15 11 303908 69 64194744
Neuralgia 26.46 10.15 52 303867 26132 64168681
Neutropenic sepsis 26.41 10.15 43 303876 23229 64171584
Walking distance test abnormal 26.41 10.15 24 303895 694 64194119
Infected skin ulcer 26.28 10.15 49 303870 2931 64191882
Mobility decreased 26.20 10.15 268 303651 85572 64109241
Breast haematoma 26.17 10.15 14 303905 165 64194648
Obstructive airways disorder 26.16 10.15 43 303876 23142 64171671
Transplant rejection 26.14 10.15 26 303893 17375 64177438
Pharyngeal haematoma 26.12 10.15 12 303907 99 64194714
Ascites 26.10 10.15 424 303495 61577 64133236
Sciatic nerve palsy 26.10 10.15 11 303908 72 64194741
Depressed mood 26.08 10.15 102 303817 40910 64153903
Schizophrenia 26.02 10.15 10 303909 11158 64183655
Alanine aminotransferase increased 25.87 10.15 480 303439 138551 64056262
Calcium deficiency 25.84 10.15 24 303895 714 64194099
Thrombectomy 25.84 10.15 16 303903 253 64194560
Transaminases increased 25.82 10.15 115 303804 44479 64150334
Hepatic failure 25.78 10.15 154 303765 55240 64139573
Ankylosing spondylitis 25.71 10.15 4 303915 8230 64186583
Drug eruption 25.54 10.15 86 303833 36050 64158763
Infusion site cellulitis 25.46 10.15 16 303903 260 64194553
Neutrophil count increased 25.43 10.15 50 303869 25124 64169689
Illness 25.40 10.15 40 303879 21898 64172915
Poisoning deliberate 25.38 10.15 16 303903 13442 64181371
Muscle spasms 25.28 10.15 490 303429 140533 64054280
Polyneuropathy 25.27 10.15 34 303885 19860 64174953
Injection site discharge 25.20 10.15 19 303900 420 64194393
Femoral nerve palsy 25.17 10.15 10 303909 55 64194758
Acne 24.95 10.15 44 303875 23037 64171776
Infusion site oedema 24.94 10.15 22 303897 611 64194202
Impaired work ability 24.93 10.15 21 303898 15198 64179615
Tumour lysis syndrome 24.92 10.15 33 303886 19407 64175406
Product storage error 24.89 10.15 16 303903 13302 64181511
Hypercalcaemia 24.88 10.15 71 303848 31345 64163468
Protein S decreased 24.78 10.15 11 303908 83 64194730
Migraine 24.77 10.15 183 303736 62494 64132319
Epstein-Barr virus infection 24.75 10.15 14 303905 12474 64182339
Acute respiratory failure 24.70 10.15 351 303568 49583 64145230
Device breakage 24.67 10.15 94 303825 8661 64186152
Ovarian haemorrhage 24.58 10.15 16 303903 277 64194536
Hyperglycaemia 24.58 10.15 177 303742 60791 64134022
Ear pain 24.48 10.15 51 303868 25085 64169728
Influenza like illness 24.46 10.15 180 303739 61522 64133291
Rash erythematous 24.36 10.15 132 303787 48501 64146312
Hyperbilirubinaemia 24.23 10.15 39 303880 21166 64173647
Gastric antral vascular ectasia 24.00 10.15 24 303895 784 64194029
Torsade de pointes 23.98 10.15 152 303767 17211 64177602
Substance abuse 23.95 10.15 7 303912 9285 64185528
Spinal cord haemorrhage 23.94 10.15 20 303899 515 64194298
Adenovirus infection 23.89 10.15 3 303916 7252 64187561
Hepatic steatosis 23.88 10.15 71 303848 30936 64163877
Purpura 23.83 10.15 151 303768 17095 64177718
Dyskinesia 23.77 10.15 100 303819 39288 64155525
Blood viscosity abnormal 23.76 10.15 6 303913 3 64194810
Status epilepticus 23.68 10.15 41 303878 21622 64173191
Encephalitis 23.64 10.15 15 303904 12556 64182257
Nightmare 23.63 10.15 39 303880 20954 64173859
Hallucination, auditory 23.56 10.15 27 303892 16912 64177901
Renal vascular thrombosis 23.53 10.15 10 303909 67 64194746
Cerebral infarction 23.40 10.15 296 303623 40748 64154065
Condition aggravated 23.39 10.15 1477 302442 370949 63823864
Lethargy 23.37 10.15 476 303443 72118 64122695
Parkinsonism 23.34 10.15 20 303899 14353 64180460
Catheter site warmth 23.33 10.15 15 303904 254 64194559
Anovulatory cycle 23.22 10.15 11 303908 98 64194715
Haemorrhagic cholecystitis 23.16 10.15 10 303909 70 64194743
Ventricular hyperkinesia 23.13 10.15 15 303904 258 64194555
Blood glucose increased 23.11 10.15 324 303595 97749 64097064
Cataract 23.08 10.15 144 303775 51118 64143695
Catheter site vesicles 23.07 10.15 16 303903 309 64194504
Mood swings 23.06 10.15 29 303890 17439 64177374
Arteriovenous fistula site haemorrhage 22.99 10.15 16 303903 311 64194502
Epilepsy 22.89 10.15 81 303838 33450 64161363
Dilatation ventricular 22.86 10.15 54 303865 3816 64190997
Cardiac pacemaker replacement 22.85 10.15 17 303902 368 64194445
Apallic syndrome 22.77 10.15 24 303895 835 64193978
Blood viscosity decreased 22.69 10.15 10 303909 74 64194739
Petechiae 22.67 10.15 158 303761 18468 64176345
Renal haematoma 22.47 10.15 22 303897 700 64194113
Device difficult to use 22.46 10.15 9 303910 9789 64185024
Haemobilia 22.39 10.15 17 303902 380 64194433
Pericardial effusion 22.34 10.15 283 303636 38971 64155842
Erythema 22.31 10.15 691 303228 186379 64008434
Heart valve operation 22.30 10.15 13 303906 183 64194630
Blood culture negative 22.30 10.15 13 303906 183 64194630
Hepatic cytolysis 22.26 10.15 20 303899 14029 64180784
Pathogen resistance 22.20 10.15 16 303903 12527 64182286
Ventricular fibrillation 22.13 10.15 190 303729 23670 64171143
Small intestinal haemorrhage 22.12 10.15 53 303866 3780 64191033
Cerebellar haematoma 22.10 10.15 20 303899 575 64194238
Incision site haemorrhage 22.09 10.15 25 303894 943 64193870
Embolism 22.07 10.15 115 303804 12120 64182693
Abortion spontaneous 22.05 10.15 54 303865 25089 64169724
Myoclonus 21.99 10.15 54 303865 25064 64169749
Anger 21.99 10.15 25 303894 15716 64179097
Hypovolaemic shock 21.73 10.15 101 303818 10165 64184648
Swelling 21.57 10.15 582 303337 159636 64035177
Iris haemorrhage 21.57 10.15 6 303913 7 64194806
Transplant dysfunction 21.55 10.15 3 303916 6705 64188108
Heart rate increased 21.44 10.15 613 303306 98062 64096751
Heart sounds abnormal 21.43 10.15 27 303892 1142 64193671
Candida infection 21.38 10.15 76 303843 31343 64163470
Back pain 21.37 10.15 962 302957 249209 63945604
Cor pulmonale 21.35 10.15 36 303883 1989 64192824
Swollen joint count increased 21.33 10.15 5 303914 7684 64187129
Psychomotor hyperactivity 21.24 10.15 22 303897 14429 64180384
Heart rate irregular 21.24 10.15 210 303709 27203 64167610
Urinary bladder rupture 21.21 10.15 10 303909 88 64194725
Nephropathy 21.18 10.15 87 303832 8299 64186514
Metastases to bone 21.16 10.15 40 303879 20395 64174418
Cardiac flutter 21.10 10.15 55 303864 4134 64190679
Haemorrhagic infarction 21.05 10.15 21 303898 684 64194129
Cardiac valve disease 21.04 10.15 63 303856 5132 64189681
Exostosis 21.03 10.15 14 303905 11424 64183389
Tongue haemorrhage 20.92 10.15 23 303896 840 64193973
Prescribed overdose 20.87 10.15 40 303879 20291 64174522
Vomiting 20.87 10.15 2276 301643 548841 63645972
Peripheral sensory neuropathy 20.82 10.15 14 303905 11364 64183449
Haemorrhagic ovarian cyst 20.80 10.15 18 303901 487 64194326
Haemorrhagic arteriovenous malformation 20.75 10.15 19 303900 555 64194258
Mental status changes 20.68 10.15 404 303515 60758 64134055
Multiple-drug resistance 20.67 10.15 3 303916 6499 64188314
Ulcer haemorrhage 20.64 10.15 57 303862 4435 64190378
Thrombotic microangiopathy 20.61 10.15 29 303890 16626 64178187
Fat embolism 20.57 10.15 16 303903 371 64194442
Angioplasty 20.54 10.15 32 303887 1653 64193160
Cholecystitis chronic 20.53 10.15 9 303910 9278 64185535
Intraocular haematoma 20.46 10.15 7 303912 23 64194790
Right ventricular dysfunction 20.41 10.15 37 303882 2166 64192647
Liver function test increased 20.36 10.15 76 303843 30894 64163919
Right atrial enlargement 20.35 10.15 15 303904 320 64194493
Blood pressure systolic decreased 20.34 10.15 89 303830 8731 64186082
Arteriovenous graft site haemorrhage 20.34 10.15 6 303913 10 64194803
Jugular vein distension 20.31 10.15 28 303891 1294 64193519
N-terminal prohormone brain natriuretic peptide increased 20.31 10.15 49 303870 3510 64191303
Left ventricular failure 20.23 10.15 86 303833 8331 64186482
Breast cancer 20.17 10.15 70 303849 29078 64165735
Carpal tunnel syndrome 20.15 10.15 27 303892 15801 64179012
Injection site urticaria 20.13 10.15 14 303905 11167 64183646
Urinary bladder haemorrhage 20.07 10.15 38 303881 2300 64192513
Aspiration pleural cavity 19.99 10.15 29 303890 1406 64193407
Poisoning 19.98 10.15 46 303873 21833 64172980
Pericarditis uraemic 19.98 10.15 6 303913 11 64194802
Acute hepatic failure 19.96 10.15 60 303859 26052 64168761
Paracentesis 19.85 10.15 27 303892 1232 64193581
Tumour haemorrhage 19.84 10.15 48 303871 3445 64191368
Hypoxia 19.82 10.15 550 303369 87599 64107214
Ubiquinone decreased 19.81 10.15 7 303912 26 64194787
Obesity 19.79 10.15 42 303877 20520 64174293
Gait disturbance 19.78 10.15 639 303280 171516 64023297
Subdural haematoma evacuation 19.70 10.15 8 303911 47 64194766
Disability 19.69 10.15 17 303902 12155 64182658
Cardiotoxicity 19.68 10.15 12 303907 10262 64184551
Multiple sclerosis 19.68 10.15 37 303882 18904 64175909
Disease recurrence 19.64 10.15 79 303840 31431 64163382
Thyroid haemorrhage 19.62 10.15 9 303910 74 64194739
Ovarian rupture 19.60 10.15 7 303912 27 64194786
Oral mucosa haematoma 19.56 10.15 8 303911 48 64194765
Factor V inhibition 19.50 10.15 15 303904 342 64194471
Blood blister 19.50 10.15 40 303879 2568 64192245
Oral candidiasis 19.47 10.15 51 303868 23161 64171652
Throat tightness 19.34 10.15 51 303868 23109 64171704
Therapeutic response shortened 19.31 10.15 12 303907 10158 64184655
Blood potassium increased 19.15 10.15 197 303722 25783 64169030
Injury 19.13 10.15 170 303749 55822 64138991
Implant site haematoma 19.11 10.15 11 303908 151 64194662
Uveitis 19.07 10.15 19 303900 12689 64182124
Agranulocytosis 19.02 10.15 104 303815 38125 64156688
Panniculitis 19.01 10.15 9 303910 8870 64185943
Xanthopsia 18.98 10.15 14 303905 299 64194514
Muscle twitching 18.96 10.15 38 303881 18960 64175853
Haemorrhagic cerebral infarction 18.95 10.15 27 303892 1287 64193526
Catheter site dermatitis 18.92 10.15 9 303910 81 64194732
Lacrimal haemorrhage 18.84 10.15 7 303912 31 64194782
Intervertebral disc protrusion 18.80 10.15 42 303877 20149 64174664
Chordae tendinae rupture 18.77 10.15 8 303911 54 64194759
Cardiac ventricular thrombosis 18.77 10.15 28 303891 1392 64193421
Akathisia 18.71 10.15 16 303903 11494 64183319
Exercise tolerance decreased 18.70 10.15 79 303840 7631 64187182
Burning sensation 18.68 10.15 147 303772 49517 64145296
Coagulation factor deficiency 18.64 10.15 9 303910 84 64194729
Progressive multifocal leukoencephalopathy 18.60 10.15 36 303883 18196 64176617
Iron deficiency anaemia 18.60 10.15 171 303748 21718 64173095
Adrenal insufficiency 18.41 10.15 50 303869 22437 64172376
Metastases to lymph nodes 18.41 10.15 9 303910 8708 64186105
Hypogammaglobulinaemia 18.41 10.15 13 303906 10286 64184527
Mitral valve repair 18.37 10.15 12 303907 209 64194604
Coeliac disease 18.36 10.15 6 303913 7406 64187407
Ovarian cyst 18.30 10.15 15 303904 11003 64183810
Haemorrhagic ascites 18.27 10.15 13 303906 262 64194551
Hepatic haematoma 18.25 10.15 21 303898 807 64194006
Sleep disorder due to a general medical condition 18.17 10.15 8 303911 8226 64186587
Injection site bruising 18.07 10.15 99 303820 36274 64158539
Hyperthyroidism 18.05 10.15 147 303772 18032 64176781
Prothrombin level abnormal 18.04 10.15 11 303908 169 64194644
Delusion 18.01 10.15 36 303883 17978 64176835
Ketoacidosis 18.01 10.15 5 303914 6858 64187955
Dysphagia 17.98 10.15 375 303544 106437 64088376
Pneumonia 17.96 10.15 2949 300970 556627 63638186
Splenic rupture 17.74 10.15 35 303884 2184 64192629
Catheter site dryness 17.69 10.15 7 303912 38 64194775
Oral disorder 17.68 10.15 10 303909 8911 64185902
Blood pressure diastolic abnormal 17.68 10.15 18 303901 11899 64182914
Large intestine polyp 17.61 10.15 99 303820 10738 64184075
Prothrombin level increased 17.55 10.15 15 303904 399 64194414
Endocarditis 17.51 10.15 89 303830 9289 64185524
Swollen tongue 17.44 10.15 95 303824 34859 64159954
Vitamin K decreased 17.41 10.15 8 303911 66 64194747
Musculoskeletal pain 17.27 10.15 274 303645 81020 64113793
Infusion site discharge 17.26 10.15 17 303902 545 64194268
Cardiac output increased 17.23 10.15 11 303908 184 64194629
Labelled drug-disease interaction medication error 17.18 10.15 13 303906 289 64194524
Intervertebral disc degeneration 17.09 10.15 22 303897 13098 64181715
Hip arthroplasty 17.09 10.15 48 303871 21303 64173510
Livedo reticularis 17.07 10.15 47 303872 3650 64191163
Body temperature increased 17.03 10.15 102 303817 36564 64158249
Heart transplant 17.02 10.15 25 303894 1226 64193587
Therapy partial responder 16.96 10.15 14 303905 10234 64184579
Gastrointestinal erosion 16.93 10.15 22 303897 960 64193853
Upper airway obstruction 16.91 10.15 25 303894 1233 64193580
Tinnitus 16.90 10.15 93 303826 34040 64160773
Bone pain 16.89 10.15 143 303776 47429 64147384
Panic attack 16.85 10.15 47 303872 20906 64173907
Injection site mass 16.85 10.15 35 303884 17235 64177578
Respiratory arrest 16.76 10.15 164 303755 52821 64141992
Spinal osteoarthritis 16.74 10.15 26 303893 14315 64180498
Procedural haemorrhage 16.69 10.15 51 303868 4201 64190612
Pulmonary haematoma 16.69 10.15 9 303910 108 64194705
Visual impairment 16.65 10.15 247 303672 73830 64120983
Blood creatinine increased 16.64 10.15 791 303128 134991 64059822
Knee arthroplasty 16.63 10.15 68 303851 26931 64167882
Pulmonary calcification 16.58 10.15 14 303905 366 64194447
Pulmonary arterial pressure abnormal 16.47 10.15 18 303901 653 64194160
Prothrombin level decreased 16.44 10.15 27 303892 1459 64193354
Protein C deficiency 16.44 10.15 6 303913 25 64194788
Implantable defibrillator replacement 16.37 10.15 5 303914 10 64194803
Prescribed underdose 16.35 10.15 38 303881 17977 64176836
Infusion site abscess 16.34 10.15 11 303908 202 64194611
Cardiac failure high output 16.32 10.15 12 303907 255 64194558
Sickle cell anaemia 16.28 10.15 17 303902 585 64194228
Unevaluable event 16.23 10.15 331 303588 50158 64144655
Demyelination 16.12 10.15 6 303913 6828 64187985
Cardio-respiratory arrest 16.11 10.15 347 303572 98046 64096767
Cerebral artery embolism 16.10 10.15 28 303891 1586 64193227
Right ventricular diastolic collapse 16.09 10.15 8 303911 80 64194733
Medical device site haematoma 16.07 10.15 6 303913 27 64194786
Thoracic haemorrhage 16.06 10.15 11 303908 208 64194605
Glaucoma 16.06 10.15 33 303886 16315 64178498
Arrhythmia 16.01 10.15 344 303575 52600 64142213
Tongue disorder 16.01 10.15 20 303899 12060 64182753
Puncture site haematoma 15.99 10.15 10 303909 161 64194652
Eschar 15.96 10.15 23 303896 1108 64193705
Mitral valve thickening 15.93 10.15 14 303905 387 64194426
Sciatica 15.89 10.15 46 303873 20218 64174595
Aortic bruit 15.88 10.15 11 303908 212 64194601
Catheter site nodule 15.86 10.15 7 303912 52 64194761
Loss of consciousness 15.86 10.15 853 303066 147512 64047301
Catheter site oedema 15.84 10.15 8 303911 83 64194730
Mitral valve disease 15.79 10.15 37 303882 2601 64192212
Angina pectoris 15.79 10.15 136 303783 44945 64149868
Eyelid ptosis 15.78 10.15 13 303906 9512 64185301
Radiation proctitis 15.76 10.15 8 303911 84 64194729
Muscle rigidity 15.74 10.15 37 303882 17436 64177377
No adverse event 15.74 10.15 75 303844 28486 64166327
Blood urea increased 15.73 10.15 294 303625 43859 64150954
Craniotomy 15.72 10.15 13 303906 330 64194483
Metastases to lung 15.70 10.15 30 303889 15234 64179579
Hip fracture 15.69 10.15 196 303723 26903 64167910
Hepatic rupture 15.64 10.15 7 303912 54 64194759
Klebsiella infection 15.58 10.15 24 303895 13257 64181556
Metastases to liver 15.57 10.15 59 303860 23882 64170931
Ischaemic stroke 15.54 10.15 207 303712 28828 64165985
Hernia repair 15.54 10.15 29 303890 1736 64193077
Liver abscess 15.53 10.15 3 303916 5277 64189536
Herpes simplex 15.53 10.15 16 303903 10520 64184293
Headache 15.52 10.15 2777 301142 526690 63668123
Metastases to central nervous system 15.51 10.15 26 303893 13886 64180927
Ulnar nerve palsy 15.47 10.15 5 303914 13 64194800
Catheter site mass 15.42 10.15 7 303912 56 64194757
Food allergy 15.27 10.15 9 303910 7842 64186971
Wound haemorrhage 15.23 10.15 43 303876 3388 64191425
Granulocytopenia 15.23 10.15 16 303903 10424 64184389
Abdominal cavity drainage 15.21 10.15 18 303901 713 64194100
Depressed level of consciousness 15.19 10.15 281 303638 81155 64113658
Arteriovenous fistula 15.16 10.15 20 303899 886 64193927
Drug tolerance decreased 15.13 10.15 7 303912 6991 64187822
Device physical property issue 15.11 10.15 32 303887 2101 64192712
Adverse drug reaction 15.11 10.15 139 303780 45325 64149488
Skin exfoliation 15.02 10.15 137 303782 44748 64150065
Drug specific antibody present 15.01 10.15 3 303916 5151 64189662
Infusion site pruritus 15.00 10.15 36 303883 2570 64192243
Incision site haematoma 15.00 10.15 9 303910 134 64194679
Hypochromasia 14.99 10.15 17 303902 643 64194170
Aplasia 14.96 10.15 7 303912 6946 64187867
Cardioactive drug level below therapeutic 14.95 10.15 5 303914 15 64194798
Odynophagia 14.95 10.15 14 303905 9627 64185186
Diabetes mellitus inadequate control 14.89 10.15 51 303868 21270 64173543
Tubulointerstitial nephritis 14.88 10.15 85 303834 30824 64163989
Right ventricular enlargement 14.85 10.15 15 303904 496 64194317
Pneumonia aspiration 14.81 10.15 375 303544 58896 64135917
Peritonitis 14.81 10.15 64 303855 24959 64169854
Enterocolitis 14.80 10.15 21 303898 11997 64182816
Respiratory failure 14.79 10.15 914 303005 160269 64034544
Blood pressure systolic abnormal 14.77 10.15 15 303904 9927 64184886
Synovial cyst 14.76 10.15 9 303910 7698 64187115
Appendicitis 14.73 10.15 112 303807 13457 64181356
Aneurysm 14.70 10.15 39 303880 2963 64191850
Coma scale normal 14.70 10.15 4 303915 4 64194809
Scleroderma 14.64 10.15 53 303866 4765 64190048
Post transplant lymphoproliferative disorder 14.64 10.15 14 303905 9530 64185283
Emergency care examination 14.62 10.15 7 303912 64 64194749
Catheter site erosion 14.62 10.15 7 303912 64 64194749
Post procedural haematoma 14.60 10.15 33 303886 2265 64192548
Hyponatraemic syndrome 14.59 10.15 18 303901 745 64194068
Left atrial enlargement 14.58 10.15 21 303898 1011 64193802
Proteinuria 14.58 10.15 74 303845 27649 64167164
Upper respiratory tract infection 14.58 10.15 248 303671 72537 64122276
Liver injury 14.58 10.15 82 303837 29850 64164963
IgA nephropathy 14.47 10.15 25 303894 1409 64193404
Dermatitis allergic 14.42 10.15 31 303888 15078 64179735
Lip haemorrhage 14.41 10.15 22 303897 1117 64193696
Ovarian cyst ruptured 14.39 10.15 19 303900 842 64193971
Nocturnal dyspnoea 14.34 10.15 24 303895 1318 64193495
Venous haemorrhage 14.15 10.15 11 303908 255 64194558
Mitral valve stenosis 14.09 10.15 21 303898 1043 64193770
Implantable defibrillator insertion 14.07 10.15 18 303901 773 64194040
Hyperlipidaemia 14.07 10.15 58 303861 22918 64171895
Malaise 14.04 10.15 2100 301819 394147 63800666
Cytomegalovirus chorioretinitis 14.02 10.15 3 303916 4909 64189904
N-telopeptide urine increased 14.02 10.15 6 303913 41 64194772
Hernia hiatus repair 14.02 10.15 6 303913 41 64194772
Application site irritation 14.01 10.15 26 303893 1550 64193263
Neutrophilia 14.01 10.15 7 303912 6687 64188126
Chronic respiratory failure 13.94 10.15 35 303884 2571 64192242
Polyomavirus-associated nephropathy 13.92 10.15 3 303916 4885 64189928
Herpes virus infection 13.88 10.15 6 303913 6238 64188575
Pre-eclampsia 13.83 10.15 6 303913 6225 64188588
Pleural effusion 13.80 10.15 729 303190 125830 64068983
Cardiac output decreased 13.77 10.15 27 303892 1677 64193136
Extrasystoles 13.72 10.15 65 303854 6593 64188220
Encephalomalacia 13.70 10.15 21 303898 1070 64193743
Mental disorder 13.68 10.15 71 303848 26374 64168439
Balloon atrial septostomy 13.64 10.15 8 303911 114 64194699
Nasopharyngitis 13.64 10.15 770 303149 195303 63999510
Haemorrhage urinary tract 13.62 10.15 31 303888 2138 64192675
Hepatitis B 13.55 10.15 10 303909 7735 64187078
Haematoma infection 13.52 10.15 23 303896 1280 64193533
Mania 13.49 10.15 36 303883 16250 64178563
Libido decreased 13.49 10.15 3 303916 4781 64190032
Oliguria 13.48 10.15 116 303803 14460 64180353
Blood viscosity increased 13.48 10.15 11 303908 274 64194539
Atrioventricular block complete 13.47 10.15 115 303804 14303 64180510
Anal fistula 13.46 10.15 4 303915 5249 64189564
Refusal of treatment by patient 13.43 10.15 76 303843 8263 64186550
Inflammatory marker increased 13.43 10.15 12 303907 8439 64186374
Creatinine renal clearance decreased 13.43 10.15 30 303889 14391 64180422
Hemianopia homonymous 13.42 10.15 22 303897 1187 64193626
Mydriasis 13.34 10.15 33 303886 15279 64179534
Medical device site haemorrhage 13.34 10.15 9 303910 166 64194647
Cardioactive drug level decreased 13.29 10.15 9 303910 167 64194646
Vision blurred 13.24 10.15 324 303595 89992 64104821
Gastrointestinal angiodysplasia 13.21 10.15 19 303900 914 64193899
Personality disorder 13.20 10.15 3 303916 4708 64190105
Blood cholinesterase decreased 13.19 10.15 10 303909 223 64194590
Burning feet syndrome 13.17 10.15 8 303911 122 64194691
Septic shock 13.17 10.15 387 303532 105050 64089763
Gastrointestinal ulcer 13.13 10.15 38 303881 3037 64191776
Renal disorder 13.13 10.15 237 303682 35128 64159685
Premature labour 13.12 10.15 10 303909 7610 64187203
Arteriovenous fistula operation 13.12 10.15 12 303907 350 64194463
Splenic haematoma 13.11 10.15 11 303908 285 64194528
Large intestinal ulcer haemorrhage 13.11 10.15 11 303908 285 64194528
Bronchospasm 13.11 10.15 55 303864 21627 64173186
Congenital tracheomalacia 13.09 10.15 3 303916 0 64194813
Oesophageal ulcer 13.07 10.15 61 303858 6149 64188664
Brain stem haemorrhage 13.06 10.15 25 303894 1526 64193287
Stevens-Johnson syndrome 13.05 10.15 101 303818 34148 64160665
Tricuspid valve incompetence 13.05 10.15 130 303789 16873 64177940
Peptic ulcer 13.05 10.15 55 303864 5308 64189505
Blood pressure diastolic increased 13.03 10.15 19 303900 10733 64184080
Intestinal haemorrhage 12.99 10.15 56 303863 5458 64189355
Human herpesvirus 6 infection 12.96 10.15 3 303916 4651 64190162
Colitis ulcerative 12.96 10.15 60 303859 22968 64171845
Acute respiratory distress syndrome 12.96 10.15 119 303800 38816 64155997
Rales 12.95 10.15 119 303800 15110 64179703
Feeling hot 12.95 10.15 145 303774 45518 64149295
Proctalgia 12.92 10.15 10 303909 7549 64187264
Malignant melanoma 12.88 10.15 26 303893 12938 64181875
Retching 12.87 10.15 119 303800 15137 64179676
Micturition urgency 12.86 10.15 18 303901 10341 64184472
Strangury 12.80 10.15 9 303910 178 64194635
Valvuloplasty cardiac 12.78 10.15 4 303915 9 64194804
Anal abscess 12.74 10.15 10 303909 7498 64187315
Stent placement 12.68 10.15 56 303863 5515 64189298
Subcapsular renal haematoma 12.66 10.15 16 303903 679 64194134
Stress cardiomyopathy 12.61 10.15 15 303904 9242 64185571
Hypophosphataemia 12.61 10.15 32 303887 14688 64180125
Cardioactive drug level above therapeutic 12.57 10.15 10 303909 240 64194573
Vaginal haematoma 12.52 10.15 8 303911 134 64194679
Procalcitonin abnormal 12.52 10.15 11 303908 304 64194509
Infusion site swelling 12.49 10.15 55 303864 5410 64189403
Dyspnoea at rest 12.48 10.15 61 303858 6268 64188545
Diastolic hypotension 12.47 10.15 8 303911 135 64194678
Nausea 12.45 10.15 3405 300514 782395 63412418
Central nervous system lesion 12.44 10.15 23 303896 11826 64182987
Drain placement 12.42 10.15 8 303911 136 64194677
Hyperthermia 12.42 10.15 35 303884 15515 64179298
Protein-losing gastroenteropathy 12.40 10.15 14 303905 527 64194286
Hepatic encephalopathy 12.39 10.15 54 303865 21012 64173801
Haemorrhoids 12.39 10.15 170 303749 23831 64170982
Dysentery 12.39 10.15 18 303901 874 64193939
Euglycaemic diabetic ketoacidosis 12.35 10.15 5 303914 5405 64189408
Cardiomegaly 12.33 10.15 168 303751 23516 64171297
Aortic valve incompetence 12.30 10.15 74 303845 8227 64186586
Gamma-glutamyltransferase increased 12.24 10.15 158 303761 48352 64146461
Application site odour 12.22 10.15 5 303914 30 64194783
Device related thrombosis 12.22 10.15 29 303890 2056 64192757
Mucormycosis 12.18 10.15 10 303909 7331 64187482
Affective disorder 12.17 10.15 8 303911 6572 64188241
Prostatic haemorrhage 12.17 10.15 8 303911 141 64194672
Vaginal infection 12.16 10.15 4 303915 4916 64189897
Coronary artery bypass 12.15 10.15 57 303862 5758 64189055
Uterine haemorrhage 12.12 10.15 33 303886 2546 64192267
Grip strength decreased 12.09 10.15 23 303896 11701 64183112
Exposure to toxic agent 12.07 10.15 7 303912 6152 64188661
Amenorrhoea 12.03 10.15 8 303911 6531 64188282
Intra-abdominal fluid collection 12.01 10.15 34 303885 2683 64192130
Arterial haemorrhage 11.97 10.15 30 303889 2201 64192612
Cervical cord compression 11.97 10.15 12 303907 393 64194420
Inhibitory drug interaction 11.97 10.15 41 303878 3586 64191227
Procalcitonin 11.96 10.15 4 303915 12 64194801
Catheter site urticaria 11.96 10.15 5 303914 32 64194781
Emotional disorder 11.92 10.15 26 303893 12581 64182232
Gastrointestinal angiectasia 11.92 10.15 12 303907 395 64194418
Alanine aminotransferase abnormal 11.91 10.15 9 303910 6879 64187934
Purple glove syndrome 11.89 10.15 10 303909 260 64194553
Bovine tuberculosis 11.88 10.15 8 303911 147 64194666
Traumatic haemorrhage 11.85 10.15 20 303899 1106 64193707
Electrolyte imbalance 11.84 10.15 70 303849 25173 64169640
Nodule 11.82 10.15 44 303875 17903 64176910
Incorrect route of product administration 11.80 10.15 63 303856 23235 64171578
Blood pressure systolic increased 11.78 10.15 163 303756 49290 64145523
Exophthalmos 11.75 10.15 24 303895 1536 64193277
Lip swelling 11.74 10.15 95 303824 31812 64163001
Joint range of motion decreased 11.74 10.15 49 303870 19294 64175519
Sickle cell anaemia with crisis 11.69 10.15 53 303866 5279 64189534
Hypertransaminasaemia 11.68 10.15 10 303909 7181 64187632
Myelodysplastic syndrome 11.64 10.15 79 303840 27500 64167313
Anaesthesia 11.63 10.15 12 303907 407 64194406
Gastroenteritis 11.62 10.15 87 303832 29624 64165189
Arterial rupture 11.57 10.15 16 303903 742 64194071
Stress 11.56 10.15 208 303711 60326 64134487
Pelvic haemorrhage 11.56 10.15 8 303911 154 64194659
Polyp 11.54 10.15 62 303857 6611 64188202
Diuretic therapy 11.52 10.15 8 303911 155 64194658
Device adhesion issue 11.50 10.15 5 303914 5181 64189632
Nephropathy toxic 11.50 10.15 43 303876 17471 64177342
Muscle strain 11.48 10.15 72 303847 8122 64186691
Pseudomonal sepsis 11.45 10.15 5 303914 5167 64189646
Disease complication 11.43 10.15 45 303874 4210 64190603
Mediastinal haemorrhage 11.42 10.15 6 303913 68 64194745
Spinal stenosis 11.39 10.15 31 303888 13900 64180913
Lip injury 11.38 10.15 18 303901 942 64193871
Device dislocation 11.34 10.15 151 303768 21027 64173786
Tardive dyskinesia 11.34 10.15 16 303903 9162 64185651
Tendon disorder 11.31 10.15 8 303911 6324 64188489
Left ventricular enlargement 11.29 10.15 15 303904 669 64194144
Dental pulp disorder 11.29 10.15 4 303915 15 64194798
Stent-graft endoleak 11.23 10.15 5 303914 38 64194775
Rehabilitation therapy 11.23 10.15 23 303896 1475 64193338
Enterococcal infection 11.23 10.15 31 303888 13835 64180978
Optic neuritis 11.22 10.15 13 303906 8103 64186710
Cholelithiasis 11.19 10.15 149 303770 45357 64149456
Acquired oesophageal web 11.18 10.15 10 303909 283 64194530
COVID-19 pneumonia 11.18 10.15 40 303879 16464 64178349
Hepatic vein thrombosis 11.14 10.15 9 303910 221 64194592
Inadequate diet 11.14 10.15 9 303910 221 64194592
Hallucination, visual 11.12 10.15 81 303838 27753 64167060
5-hydroxyindolacetic acid increased 11.09 10.15 4 303915 16 64194797
Eye haematoma 11.07 10.15 7 303912 115 64194698
IgM nephropathy 11.02 10.15 3 303916 3 64194810
Factor II mutation 11.02 10.15 3 303916 3 64194810
Biliary tract operation 11.02 10.15 3 303916 3 64194810
Dry skin 11.01 10.15 172 303747 50989 64143824
Photophobia 11.00 10.15 43 303876 17250 64177563
Ischaemic hepatitis 10.98 10.15 37 303882 3209 64191604
Urinary incontinence 10.97 10.15 113 303806 36038 64158775
Heart disease congenital 10.94 10.15 13 303906 517 64194296
Injection site pustule 10.91 10.15 6 303913 75 64194738
Pulmonary resection 10.91 10.15 5 303914 41 64194772
Catheter site extravasation 10.91 10.15 11 303908 363 64194450
Complications of transplanted kidney 10.90 10.15 6 303913 5429 64189384
Aortic aneurysm rupture 10.87 10.15 20 303899 1184 64193629
Thromboembolectomy 10.84 10.15 6 303913 76 64194737
Fungal infection 10.84 10.15 106 303813 34145 64160668
Incarcerated hernia 10.83 10.15 11 303908 366 64194447
Drug abuser 10.82 10.15 7 303912 5801 64189012
Skin fissures 10.82 10.15 20 303899 10286 64184527
Application site pruritus 10.81 10.15 39 303880 3500 64191313
Vaginal haemorrhage 10.81 10.15 139 303780 19205 64175608
Dysaesthesia 10.79 10.15 5 303914 4990 64189823
Investigation 10.77 10.15 29 303890 2223 64192590
Subileus 10.73 10.15 5 303914 4972 64189841
Cystitis haemorrhagic 10.72 10.15 13 303906 7943 64186870
Bladder necrosis 10.72 10.15 4 303915 18 64194795
Intracranial haematoma 10.70 10.15 16 303903 797 64194016
Cushingoid 10.70 10.15 12 303907 7591 64187222
Eye infection 10.67 10.15 17 303902 9264 64185549
Thyrotoxic crisis 10.67 10.15 19 303900 1097 64193716
Salivary hypersecretion 10.63 10.15 26 303893 12087 64182726
Forced expiratory volume decreased 10.62 10.15 10 303909 6857 64187956
Gastrointestinal pain 10.61 10.15 12 303907 7562 64187251
Blood pressure immeasurable 10.60 10.15 26 303893 1882 64192931
Personality change 10.60 10.15 15 303904 8578 64186235
Colon cancer 10.56 10.15 99 303820 12640 64182173
Oropharyngeal discomfort 10.54 10.15 6 303913 5329 64189484
Mitral perforation 10.54 10.15 4 303915 19 64194794
Vessel puncture site haemorrhage 10.53 10.15 8 303911 179 64194634
Cardiac pseudoaneurysm 10.51 10.15 5 303914 45 64194768
Cerebellar infarction 10.50 10.15 37 303882 3282 64191531
Ataxia 10.48 10.15 61 303858 22023 64172790
Nephrosclerosis 10.48 10.15 23 303896 1548 64193265
Hemiplegia 10.47 10.15 99 303820 12669 64182144
Abdominal pain upper 10.47 10.15 697 303222 174333 64020480
Angiodysplasia 10.47 10.15 16 303903 813 64194000
Skin reaction 10.47 10.15 27 303892 12325 64182488
Tri-iodothyronine increased 10.45 10.15 8 303911 181 64194632
Infusion site vesicles 10.45 10.15 11 303908 382 64194431
Coagulation factor V level increased 10.42 10.15 5 303914 46 64194767
Face oedema 10.41 10.15 71 303848 24690 64170123
Erectile dysfunction 10.40 10.15 28 303891 12599 64182214
Eosinophilia 10.37 10.15 122 303797 37954 64156859
Aspartate aminotransferase increased 10.34 10.15 460 303459 119328 64075485
Decreased immune responsiveness 10.33 10.15 4 303915 4444 64190369
Pyelonephritis 10.32 10.15 44 303875 17222 64177591
Coordination abnormal 10.31 10.15 36 303883 14928 64179885
Bipolar disorder 10.27 10.15 10 303909 6751 64188062
Femoral artery aneurysm 10.27 10.15 8 303911 186 64194627
Therapy interrupted 10.25 10.15 54 303865 19982 64174831
Brain natriuretic peptide 10.23 10.15 5 303914 48 64194765
Adnexal torsion 10.23 10.15 8 303911 187 64194626
Heart and lung transplant 10.23 10.15 8 303911 187 64194626
Procedural pain 10.23 10.15 38 303881 15470 64179343
Parathyroid gland operation 10.22 10.15 4 303915 21 64194792
Thyroiditis acute 10.20 10.15 8 303911 188 64194625
Paranoia 10.19 10.15 41 303878 16311 64178502
Large intestinal polypectomy 10.17 10.15 9 303910 251 64194562

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AA03 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Vitamin K antagonists
FDA EPC N0000175476 Vitamin K Antagonist
CHEBI has role CHEBI:33288 rodenticides
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:50390 NAD(P)H dehydrogenase (quinone) inhibitors
CHEBI has role CHEBI:55347 vitamin K antagonists
MeSH PA D000925 Anticoagulants
MeSH PA D006401 Hematologic Agents
MeSH PA D010575 Pesticides
MeSH PA D012378 Rodenticides
FDA MoA N0000175964 Vitamin K Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cerebral embolism indication 75543006 DOID:4372
Deep venous thrombosis indication 128053003
Pulmonary thromboembolism indication 233935004
Thromboembolic disorder indication 371039008
Thrombosis indication 439127006
Prevention of deep vein thrombosis indication 439993001
Prevention of Thromboembolism with Chronic Atrial Fibrillation indication
Thromboembolism due to Prosthetic Heart Valves indication
Pulmonary Thromboembolism Prevention indication
Deep Vein Thrombosis with Pulmonary Embolism indication
Myocardial Reinfarction Prevention indication
Thrombophilia off-label use 234467004 DOID:2452
Heart Failure with Paroxysmal Atrial Fibrillation off-label use
Nutritional disorder contraindication 2492009 DOID:374
Pericarditis contraindication 3238004 DOID:1787
Necrosis contraindication 6574001
Alcoholism contraindication 7200002
Obstruction of bile duct contraindication 30144000
Vasculitis contraindication 31996006 DOID:865
Hyperthyroidism contraindication 34486009 DOID:7998
Gangrene contraindication 36024000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Secondary uterine inertia contraindication 43715006
Tropical sprue contraindication 47384003 DOID:10607
Nephrotic syndrome contraindication 52254009 DOID:1184
Vitamin K deficiency contraindication 52675005 DOID:11249
Threatened abortion contraindication 54048003 DOID:9667
Hyperlipidemia contraindication 55822004 DOID:1168
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Fatty stool contraindication 66187002
Psychotic disorder contraindication 69322001
Heparin-induced thrombocytopenia contraindication 73397007
Gastrointestinal hemorrhage contraindication 74474003
Protein C deficiency disease contraindication 76407009 DOID:3756
Respiratory tract hemorrhage contraindication 95431003
Disorder of connective tissue contraindication 105969002 DOID:65
Polycythemia vera contraindication 109992005
Procedure on central nervous system contraindication 118679007
Intracranial aneurysm contraindication 128609009 DOID:10941
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Eclampsia in pregnancy contraindication 198992004
Local anesthetic intrathecal block contraindication 231249005
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Lumbar puncture contraindication 277762005
Pregnancy, function contraindication 289908002
Bacterial endocarditis contraindication 301183007
Dissection of aorta contraindication 308546005
Primary malignant neoplasm contraindication 372087000
Surgical procedure on eye proper contraindication 373353005
Pericardial effusion contraindication 373945007 DOID:118
Fever contraindication 386661006
Surgical procedure contraindication 387713003
Severe diarrhea contraindication 409587002
Traumatic injury contraindication 417746004
Genitourinary tract hemorrhage contraindication 417941003
Poor metabolizer due to cytochrome p450 CYP2C9 variant contraindication 424451001
Hypertensive urgency contraindication 443482000
Cholesterol Embolism contraindication
Indwelling Vascular Catheter contraindication
Severe Diabetes Mellitus contraindication
Internal Hemorrhage contraindication
Bleeding Risk Associated with Vitamin-K-Epoxide Reductase (Warfarin-Sensitive) Gene contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.96 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin K epoxide reductase complex subunit 1 Enzyme INHIBITOR IC50 7 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 3.98 WOMBAT-PK
Cytochrome P450 2C9 Enzyme Ki 4.87 WOMBAT-PK
Proprotein convertase subtilisin/kexin type 7 Enzyme IC50 4.61 CHEMBL
Vitamin K epoxide reductase complex subunit 1-like protein 1 Enzyme Ki 4.28 SCIENTIFIC LITERATURE

External reference:

IDSource
4019972 VUID
N0000148057 NUI
D00564 KEGG_DRUG
129-06-6 SECONDARY_CAS_RN
2610-86-8 SECONDARY_CAS_RN
4018548 VANDF
4019972 VANDF
C0043031 UMLSCUI
CHEBI:10033 CHEBI
CHEMBL1464 ChEMBL_ID
DB00682 DRUGBANK_ID
CHEMBL1200879 ChEMBL_ID
D014859 MESH_DESCRIPTOR_UI
54678486 PUBCHEM_CID
6853 IUPHAR_LIGAND_ID
341 INN_ID
5Q7ZVV76EI UNII
11289 RXNORM
1258 MMSL
5693 MMSL
d00022 MMSL
002084 NDDF
002085 NDDF
004065 NDDF
372756006 SNOMEDCT_US
41509001 SNOMEDCT_US
48603004 SNOMEDCT_US
63167009 SNOMEDCT_US
CHEMBL1200772 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1712 TABLET 1 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1713 TABLET 2 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1714 TABLET 2.50 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1715 TABLET 3 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1716 TABLET 4 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1718 TABLET 6 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1720 TABLET 10 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1721 TABLET 5 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1723 TABLET 7.50 mg ORAL ANDA 29 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1211 TABLET 1 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1212 TABLET 2 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1213 TABLET 2.50 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1214 TABLET 3 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1215 TABLET 4 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1216 TABLET 5 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1217 TABLET 6 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1218 TABLET 7.50 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1219 TABLET 10 mg ORAL ANDA 30 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16590-340 TABLET 2.50 mg ORAL ANDA 31 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16590-341 TABLET 5 mg ORAL ANDA 31 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 17856-4034 TABLET 7.50 mg ORAL ANDA 32 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-672 TABLET 1 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-673 TABLET 2 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-674 TABLET 2.50 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-675 TABLET 3 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-677 TABLET 5 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-801 TABLET 10 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-939 TABLET 10 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-940 TABLET 10 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-327 TABLET 1 mg ORAL ANDA 28 sections