warfarin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2847 81-81-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • warfarin
  • warfarin sodium
  • warfarin potassium
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
  • Molecular weight: 308.33
  • Formula: C19H16O4
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -3.82
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
7.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.54 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.13 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.06 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 29 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.024 Moderate 0.77
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.963 Moderate 0.77
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 61.802 10^-6 cm/s Moderate 0.77
dh-clint Dog hepatocyte intrinsic clearance 3.034 uL/min/10^6 cells Moderate 0.77
dppb Dog plasma protein binding (% unbound) 2.580 % Moderate 0.77
fcs-ppb Fetal calf serum protein binding (% unbound) 3.330 % Moderate 0.77
herg hERG pIC50 4.244 pIC50 Moderate 0.77
hh-clint Human hepatocyte intrinsic clearance 1.923 uL/min/10^6 cells Moderate 0.77
hlm-clint Human liver microsomal intrinsic clearance 3.266 uL/min/mg protein Moderate 0.77
hppb Human plasma protein binding (% unbound) 1.030 % Moderate 0.77
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 54
kinase-selectivity-class ACVR2B,AXL,BRAF,EIF2AK3,GRK2,MAPK7,PDK4,STK33,TEK 9
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.312 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 6.934 Moderate 0.77
mh-clint Mouse hepatocyte intrinsic clearance 6.950 Moderate 0.77
mppb Mouse plasma protein binding (% unbound) 4.510 Moderate 0.77
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.148 Moderate 0.77
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 2.170 % Moderate 0.77
rat-kpuu-brain Rat brain Kpuu 0.389 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.774 uL/min/10^6 cells Moderate 0.77
rh-fuinc Rat hepatocyte fraction unbound in incubation 77.170 % Moderate 0.77
rppb Rat plasma protein binding (% unbound) 1.260 % Moderate 0.77
solubility-dd Solubility at pH 7.4 in DMSO 859.014 uM Moderate 0.77

Approvals:

DateAgencyCompanyOrphan
June 8, 1954 FDA BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 10365.32 10.40 3945 204412 43371 90376719
Drug interaction 1820.86 10.40 2679 205678 273774 90146316
Calciphylaxis 1244.49 10.40 415 207942 2961 90417129
International normalised ratio decreased 1042.94 10.40 397 207960 4327 90415763
International normalised ratio abnormal 1017.09 10.40 369 207988 3476 90416614
Pulmonary arterial hypertension 1005.48 10.40 670 207687 25517 90394573
Gastrointestinal haemorrhage 871.53 10.40 1056 207301 89192 90330898
Anticoagulation drug level above therapeutic 815.29 10.40 266 208091 1756 90418334
Dyspnoea 783.46 10.40 4038 204319 876917 89543173
Haematoma 721.39 10.40 647 207710 38401 90381689
Synovitis 706.17 10.40 10 208347 329742 90090348
Haemorrhage 691.40 10.40 825 207532 68544 90351546
Cardiac failure congestive 674.73 10.40 975 207382 97719 90322371
Drug ineffective 663.24 10.40 1373 206984 1382925 89037165
Atrial fibrillation 614.46 10.40 1102 207255 132509 90287581
Glossodynia 596.15 10.40 36 208321 321743 90098347
Epistaxis 589.19 10.40 846 207511 84279 90335811
International normalised ratio fluctuation 573.34 10.40 229 208128 2864 90417226
Fluid retention 568.45 10.40 847 207510 87244 90332846
Subdural haematoma 556.29 10.40 391 207966 16254 90403836
Hand deformity 552.49 10.40 32 208325 296330 90123760
Infusion related reaction 550.52 10.40 140 208217 416640 90003450
Pain in jaw 547.50 10.40 612 207745 47373 90372717
Pulmonary hypertension 542.12 10.40 575 207782 41948 90378142
Haemoglobin decreased 493.76 10.40 1126 207231 160830 90259260
Cerebral haemorrhage 492.70 10.40 496 207861 34026 90386064
Labelled drug-drug interaction medication error 476.79 10.40 338 208019 14244 90405846
Duodenal ulcer perforation 476.71 10.40 6 208351 221282 90198808
Melaena 474.85 10.40 488 207869 34309 90385781
Helicobacter infection 464.90 10.40 12 208345 226838 90193252
Right ventricular failure 463.10 10.40 371 207986 18834 90401256
Hypervolaemia 460.83 10.40 467 207890 32290 90387800
Drug intolerance 458.97 10.40 228 208129 447363 89972727
Contraindicated product administered 449.55 10.40 94 208263 320045 90100045
Pericarditis 443.38 10.40 51 208306 270100 90149990
Anaemia 442.73 10.40 1793 206564 351009 90069081
Arthropathy 441.35 10.40 146 208211 366096 90053994
Folliculitis 438.17 10.40 6 208351 204347 90215743
Joint swelling 437.89 10.40 312 208045 502988 89917102
Treatment failure 433.48 10.40 86 208271 303842 90116248
Systemic lupus erythematosus 431.33 10.40 147 208210 361749 90058341
Prothrombin time prolonged 423.95 10.40 270 208087 9502 90410588
Cardiac failure 419.97 10.40 836 207521 108660 90311430
Psoriatic arthropathy 415.47 10.40 28 208329 228307 90191783
Dyspnoea exertional 411.47 10.40 656 207701 71632 90348458
Catheter site erythema 404.26 10.40 206 208151 4688 90415402
Alopecia 403.67 10.40 328 208029 494743 89925347
Off label use 398.35 10.40 1259 207098 1100993 89319097
Hepatic enzyme increased 397.37 10.40 166 208191 360570 90059520
Wound 388.08 10.40 108 208249 302872 90117218
Hypotension 387.86 10.40 1628 206729 323769 90096321
Device related infection 378.10 10.40 376 207981 25410 90394680
Muscle injury 367.10 10.40 8 208349 176646 90243444
Irritable bowel syndrome 361.67 10.40 31 208326 207417 90212673
Therapeutic product effect decreased 353.50 10.40 100 208257 277471 90142619
Rheumatoid arthritis 353.44 10.40 197 208160 362417 90057673
Coagulopathy 351.51 10.40 345 208012 22944 90397146
Death 348.41 10.40 2011 206346 454540 89965550
Syncope 347.69 10.40 870 207487 131793 90288297
Type 2 diabetes mellitus 334.35 10.40 38 208319 203206 90216884
Catheter site pain 332.36 10.40 189 208168 5390 90414700
Stomatitis 331.70 10.40 109 208248 274589 90145501
Thrombosis 329.91 10.40 599 207758 72652 90347438
Hypersensitivity 329.18 10.40 336 208021 454341 89965749
Discomfort 318.92 10.40 116 208241 274219 90145871
Abdominal wall haematoma 314.97 10.40 154 208203 3198 90416892
Musculoskeletal stiffness 306.83 10.40 149 208208 296383 90123707
Catheter management 292.84 10.40 142 208215 2894 90417196
Transfusion 292.18 10.40 274 208083 17214 90402876
Anticoagulation drug level below therapeutic 290.00 10.40 95 208262 636 90419454
Haemorrhage intracranial 287.42 10.40 255 208102 14907 90405183
Haemoptysis 281.66 10.40 365 207992 32955 90387135
Impaired healing 279.10 10.40 95 208262 234104 90185986
Fibromyalgia 270.69 10.40 70 208287 206199 90213891
Sleep disorder due to general medical condition, insomnia type 270.67 10.40 5 208352 128689 90291401
Haematuria 269.59 10.40 366 207991 34571 90385519
Drug hypersensitivity 266.14 10.40 409 207948 463200 89956890
Blood cholesterol increased 264.67 10.40 75 208282 207937 90212153
Blister 246.23 10.40 140 208217 254858 90165232
Oedema peripheral 245.49 10.40 1208 207149 256707 90163383
Fall 243.72 10.40 1917 206440 479893 89940197
Liver injury 243.60 10.40 48 208309 170519 90249571
Ill-defined disorder 238.32 10.40 65 208292 184826 90235264
Catheter site infection 229.91 10.40 150 208207 5504 90414586
Product use issue 226.13 10.40 255 208102 329664 90090426
Product use in unapproved indication 224.94 10.40 265 208092 335971 90084119
Deep vein thrombosis 224.56 10.40 586 207771 91034 90329056
Pulmonary embolism 222.09 10.40 734 207623 130086 90290004
Arthralgia 221.75 10.40 979 207378 777543 89642547
Catheter site discharge 221.35 10.40 109 208248 2300 90417790
Catheter site pruritus 220.02 10.40 107 208250 2195 90417895
Sleep disorder 218.08 10.40 91 208266 197939 90222151
Muscle haemorrhage 217.39 10.40 120 208237 3226 90416864
Lip dry 216.18 10.40 3 208354 100952 90319138
Mobility decreased 213.08 10.40 159 208198 250575 90169515
Bursitis 210.60 10.40 27 208330 131627 90288463
Facet joint syndrome 210.35 10.40 3 208354 98386 90321704
Injury 204.30 10.40 99 208258 197250 90222840
Lower respiratory tract infection 204.07 10.40 166 208191 250493 90169597
Rash 202.22 10.40 1043 207314 795057 89625033
Palpitations 200.68 10.40 731 207626 135997 90284093
Ecchymosis 199.98 10.40 190 208167 12133 90407957
Flushing 198.74 10.40 548 207809 87943 90332147
Central venous catheterisation 197.90 10.40 106 208251 2680 90417410
Rectal haemorrhage 195.42 10.40 522 207835 82222 90337868
Joint range of motion decreased 194.04 10.40 38 208319 135605 90284485
Infusion site pain 190.39 10.40 231 208126 19507 90400583
Maternal exposure during pregnancy 190.33 10.40 335 208022 359728 90060362
Heparin-induced thrombocytopenia 189.71 10.40 130 208227 5182 90414908
Catheter site haemorrhage 188.72 10.40 113 208244 3555 90416535
Wheezing 181.27 10.40 168 208189 237912 90182178
Osteoarthritis 181.11 10.40 113 208244 195617 90224473
Therapeutic product effect incomplete 177.95 10.40 113 208244 193783 90226307
General physical health deterioration 176.51 10.40 343 208014 354772 90065318
Acute kidney injury 175.31 10.40 1299 207058 319088 90101002
Oxygen saturation decreased 174.37 10.40 594 207763 106889 90313201
Urticaria 173.51 10.40 282 208075 312452 90107638
Cerebrovascular accident 173.34 10.40 651 207706 122882 90297208
Hypercholesterolaemia 173.28 10.40 16 208341 100876 90319214
Coagulation time prolonged 168.92 10.40 81 208276 1609 90418481
Abdominal discomfort 166.12 10.40 553 207804 476775 89943315
Gastrointestinal disorder 165.58 10.40 208 208149 256479 90163611
Hypertension 163.41 10.40 524 207833 457008 89963082
Bradycardia 162.93 10.40 493 207864 83354 90336736
Device alarm issue 157.60 10.40 80 208277 1805 90418285
Inflammation 157.25 10.40 109 208248 178483 90241607
Hypoaesthesia 156.55 10.40 303 208054 313907 90106183
Retroperitoneal haematoma 155.97 10.40 97 208260 3271 90416819
Grip strength decreased 155.52 10.40 16 208341 92560 90327530
Obesity 154.22 10.40 28 208329 105479 90314611
Catheter site swelling 154.18 10.40 78 208279 1747 90418343
C-reactive protein increased 154.09 10.40 115 208242 181274 90238816
Exposure during pregnancy 153.96 10.40 193 208164 238217 90181873
Device leakage 152.60 10.40 149 208208 9842 90410248
Sinusitis 152.41 10.40 353 208004 342735 90077355
Pain 152.02 10.40 1512 206845 994829 89425261
Catheter placement 151.68 10.40 86 208271 2438 90417652
Pneumonia aspiration 150.18 10.40 307 208050 40633 90379457
Blood pressure decreased 149.89 10.40 445 207912 74450 90345640
Upper gastrointestinal haemorrhage 149.63 10.40 222 208135 22754 90397336
Prescribed overdose 149.14 10.40 23 208334 97602 90322488
Infection 147.98 10.40 389 207968 361705 90058385
Retroperitoneal haemorrhage 145.91 10.40 90 208267 2990 90417100
Pulmonary oedema 144.91 10.40 390 207967 61690 90358400
Subdural haemorrhage 144.56 10.40 93 208264 3330 90416760
Swelling 142.00 10.40 491 207866 418567 90001523
Subarachnoid haemorrhage 138.77 10.40 188 208169 17716 90402374
Hospitalisation 137.05 10.40 621 207736 127479 90292611
Prothrombin time abnormal 136.76 10.40 50 208307 482 90419608
Thrombosis in device 135.96 10.40 86 208271 2989 90417101
Deep vein thrombosis postoperative 133.82 10.40 7 208350 70802 90349288
Asthma 132.74 10.40 220 208137 241940 90178150
Night sweats 131.11 10.40 66 208291 128700 90291390
Psoriasis 127.66 10.40 92 208265 147662 90272428
Cardiac disorder 127.47 10.40 352 208005 56520 90363570
Presyncope 124.43 10.40 245 208112 31560 90388530
Haematemesis 123.82 10.40 253 208104 33473 90386617
Wound infection 123.53 10.40 45 208312 106357 90313733
Autoimmune disorder 122.09 10.40 16 208341 76728 90343362
Cardiac pacemaker insertion 121.11 10.40 92 208265 4315 90415775
Skin necrosis 120.97 10.40 171 208186 16770 90403320
Paraesthesia 119.84 10.40 247 208110 250079 90170011
Nasal congestion 119.00 10.40 442 207915 82972 90337118
Peripheral venous disease 118.98 10.40 24 208333 83897 90336193
Febrile neutropenia 117.83 10.40 114 208243 158235 90261855
Atrial flutter 117.18 10.40 134 208223 10624 90409466
Renal failure 117.00 10.40 603 207754 130404 90289686
Infusion site infection 116.63 10.40 74 208283 2586 90417504
Blepharospasm 113.26 10.40 3 208354 55442 90364648
Dehydration 111.75 10.40 798 207559 193649 90226441
Activated partial thromboplastin time prolonged 110.82 10.40 112 208245 7713 90412377
Device occlusion 110.33 10.40 121 208236 9161 90410929
Lung transplant 110.22 10.40 81 208276 3611 90416479
Complication associated with device 109.91 10.40 176 208181 19273 90400817
Infusion site erythema 109.70 10.40 146 208211 13524 90406566
Shock haemorrhagic 109.55 10.40 138 208219 12107 90407983
Faeces discoloured 108.46 10.40 184 208173 21136 90398954
Blood loss anaemia 108.26 10.40 125 208232 10015 90410075
Intentional product use issue 108.11 10.40 209 208148 216683 90203407
Prescribed underdose 107.31 10.40 21 208336 74998 90345092
Haemorrhage subcutaneous 107.05 10.40 77 208280 3319 90416771
Haemorrhagic stroke 107.01 10.40 101 208256 6395 90413695
Catheter site inflammation 105.27 10.40 49 208308 908 90419182
Dialysis 105.07 10.40 130 208227 11199 90408891
Sciatica 104.66 10.40 51 208306 101331 90318759
Depression 101.89 10.40 352 208005 300249 90119841
Cellulitis 101.60 10.40 448 207909 90889 90329201
Pruritus 101.26 10.40 779 207578 540746 89879344
Red blood cell sedimentation rate increased 100.97 10.40 32 208325 82563 90337527
Chest pain 98.04 10.40 1145 207212 318500 90101590
Dry mouth 96.47 10.40 172 208185 183887 90236203
Cardiac valve replacement complication 95.64 10.40 28 208329 121 90419969
Injection site reaction 95.54 10.40 46 208311 92034 90328056
Dizziness 95.40 10.40 1892 206465 587392 89832698
Pulmonary thrombosis 95.18 10.40 115 208242 9667 90410423
Pulmonary arterial pressure increased 95.14 10.40 76 208281 3840 90416250
Lower gastrointestinal haemorrhage 93.90 10.40 109 208248 8783 90411307
Catheter site rash 93.36 10.40 43 208314 777 90419313
Catheterisation cardiac 93.22 10.40 83 208274 4873 90415217
Intra-abdominal haematoma 92.40 10.40 59 208298 2085 90418005
Sepsis 92 10.40 718 207639 179096 90240994
X-ray abnormal 90.81 10.40 3 208354 45421 90374669
Nail disorder 87.79 10.40 15 208342 59052 90361038
Pneumonia 87.57 10.40 2000 206357 636059 89784031
Lupus-like syndrome 85.90 10.40 7 208350 48839 90371251
Myelosuppression 85.66 10.40 11 208346 53580 90366510
Road traffic accident 85.40 10.40 73 208284 107553 90312537
Head injury 85.27 10.40 208 208149 30980 90389110
Pulmonary fibrosis 83.99 10.40 74 208283 107429 90312661
Intra-abdominal haemorrhage 83.09 10.40 60 208297 2602 90417488
Unevaluable event 82.75 10.40 296 208061 54552 90365538
Hyperkalaemia 82.64 10.40 332 208025 64632 90355458
Exostosis 82.34 10.40 12 208345 53122 90366968
Heart rate increased 82.32 10.40 492 207865 112410 90307680
Device related sepsis 81.79 10.40 76 208281 4717 90415373
Pleural effusion 81.63 10.40 488 207869 111503 90308587
Haematocrit decreased 81.27 10.40 246 208111 41586 90378504
Foot deformity 80.62 10.40 19 208338 59632 90360458
Acute respiratory failure 80.22 10.40 249 208108 42669 90377421
Onychomadesis 79.77 10.40 7 208350 45991 90374099
Respiratory failure 78.77 10.40 504 207853 117914 90302176
Gout 78.58 10.40 140 208217 16719 90403371
Vascular device infection 78.56 10.40 116 208241 11836 90408254
Live birth 78.36 10.40 42 208315 79065 90341025
Asthenia 77.90 10.40 1688 206669 532063 89888027
Coagulation test abnormal 77.67 10.40 40 208317 931 90419159
Ventricular tachycardia 76.50 10.40 173 208184 24535 90395555
Gait inability 75.71 10.40 138 208219 146318 90273772
Internal haemorrhage 75.52 10.40 82 208275 6138 90413952
Haemarthrosis 75.35 10.40 67 208290 3927 90416163
Cardioactive drug level increased 75.02 10.40 54 208303 2330 90417760
Hypoxia 74.45 10.40 347 208010 72052 90348038
Spinal epidural haematoma 73.61 10.40 43 208314 1291 90418799
Arrhythmia 72.20 10.40 238 208119 42094 90377996
Sleep disorder due to a general medical condition 71.95 10.40 9 208348 44729 90375361
Subcutaneous haematoma 71.81 10.40 48 208309 1835 90418255
Therapy change 71.62 10.40 92 208265 8230 90411860
Loss of personal independence in daily activities 71.47 10.40 127 208230 135978 90284112
Hypercoagulation 71.05 10.40 51 208306 2191 90417899
Vascular pseudoaneurysm 70.76 10.40 46 208311 1677 90418413
Torsade de pointes 70.67 10.40 126 208231 15056 90405034
Cardiac arrest 70.65 10.40 448 207909 104487 90315603
Ascites 70.62 10.40 256 208101 47484 90372606
Dermatitis contact 70.04 10.40 118 208239 13477 90406613
Prosthetic cardiac valve thrombosis 69.82 10.40 18 208339 42 90420048
Cough 69.79 10.40 1214 207143 367748 90052342
Coeliac disease 69.30 10.40 10 208347 44600 90375490
Post procedural haemorrhage 69.12 10.40 93 208264 8705 90411385
Malignant neoplasm progression 68.44 10.40 87 208270 106783 90313307
Gastric haemorrhage 68.29 10.40 83 208274 7020 90413070
Cardiac operation 68.13 10.40 63 208294 3886 90416204
Haematoma muscle 67.78 10.40 46 208311 1804 90418286
Potentiating drug interaction 67.62 10.40 74 208283 5588 90414502
Epilepsy 67.39 10.40 54 208303 82152 90337938
Diarrhoea 65.90 10.40 2711 205646 936479 89483611
Spontaneous haematoma 65.69 10.40 38 208319 1120 90418970
Hip arthroplasty 65.10 10.40 48 208309 76160 90343930
Brain natriuretic peptide increased 64.06 10.40 74 208283 5931 90414159
Therapeutic response decreased 63.99 10.40 67 208290 89662 90330428
Cardiac ablation 63.94 10.40 43 208314 1661 90418429
Lower limb fracture 63.46 10.40 61 208296 84952 90335138
Gingival bleeding 63.44 10.40 119 208238 14784 90405306
Device infusion issue 63.26 10.40 51 208306 2611 90417479
Injection site pain 63.24 10.40 197 208160 173502 90246588
Knee arthroplasty 62.90 10.40 59 208298 83123 90336967
Intraventricular haemorrhage 62.30 10.40 49 208308 2420 90417670
Catheter site irritation 61.66 10.40 30 208327 616 90419474
Hypocoagulable state 61.56 10.40 41 208316 1558 90418532
Coma 61.16 10.40 329 208028 72303 90347787
Cardiac failure chronic 60.94 10.40 70 208287 5576 90414514
Pulmonary endarterectomy 60.66 10.40 20 208337 137 90419953
Transplant evaluation 60.40 10.40 38 208319 1308 90418782
Myocardial infarction 60.30 10.40 434 207923 105538 90314552
Liver function test increased 59.79 10.40 64 208293 84791 90335299
Loss of consciousness 59.48 10.40 537 207820 139701 90280389
Blood potassium decreased 58.39 10.40 241 208116 47486 90372604
Pericardial haemorrhage 57.91 10.40 42 208315 1834 90418256
Taste disorder 57.63 10.40 35 208322 61511 90358579
Malaise 56.96 10.40 1756 206601 584230 89835860
Haemoperitoneum 56.49 10.40 54 208303 3474 90416616
Vaginal haemorrhage 56.21 10.40 179 208178 31092 90388998
Tongue haematoma 55.93 10.40 18 208339 113 90419977
Hypovolaemic shock 55.75 10.40 75 208282 7019 90413071
Heart rate irregular 55.16 10.40 151 208206 24117 90395973
Oxygen consumption increased 54.85 10.40 60 208297 4529 90415561
Joint stiffness 54.84 10.40 59 208298 77983 90342107
Catheter site related reaction 54.83 10.40 33 208324 1048 90419042
Muscle spasticity 54.68 10.40 8 208349 35314 90384776
Onychomycosis 54.43 10.40 10 208347 37366 90382724
Cardiac failure acute 54.24 10.40 98 208259 11831 90408259
Immunodeficiency 54.19 10.40 16 208341 43218 90376872
Feeling abnormal 53.87 10.40 605 207752 166630 90253460
Congestive hepatopathy 53.52 10.40 49 208308 2984 90417106
Drug-induced liver injury 53.31 10.40 78 208279 90240 90329850
Cerebellar haemorrhage 53.30 10.40 38 208319 1615 90418475
Laryngitis 53.19 10.40 25 208332 50728 90369362
Pulmonary haemorrhage 53.00 10.40 78 208279 7935 90412155
Dyspnoea at rest 52.73 10.40 60 208297 4731 90415359
Medical device change 52.71 10.40 22 208335 310 90419780
Ischaemic stroke 52.46 10.40 140 208217 22026 90398064
Cardioversion 52.43 10.40 35 208322 1335 90418755
Pelvic haematoma 52.41 10.40 28 208329 704 90419386
Prothrombin time ratio increased 52.39 10.40 17 208340 110 90419980
Anaphylactic reaction 52.24 10.40 75 208282 87449 90332641
Pregnancy 51.81 10.40 40 208317 62007 90358083
Pericardial effusion 51.53 10.40 194 208163 36639 90383451
Joint dislocation 51.49 10.40 19 208338 44563 90375527
Device expulsion 51.49 10.40 15 208342 40871 90379219
Blood viscosity decreased 51.05 10.40 14 208343 45 90420045
Choroidal haemorrhage 50.82 10.40 14 208343 46 90420044
Lethargy 50.48 10.40 282 208075 62857 90357233
Drug tolerance decreased 50.38 10.40 7 208350 32123 90387967
Liver function test abnormal 50.30 10.40 241 208116 50604 90369486
Anticoagulation drug level increased 50.18 10.40 21 208336 298 90419792
Atrial tachycardia 49.65 10.40 65 208292 5925 90414165
Neutropenia 49.60 10.40 308 208049 224596 90195494
Catheter removal 49.09 10.40 22 208335 372 90419718
Orthopnoea 48.81 10.40 69 208288 6766 90413324
Occult blood positive 48.78 10.40 53 208304 3970 90416120
Antiphospholipid syndrome 48.67 10.40 41 208316 2233 90417857
Brain herniation 48.62 10.40 54 208303 4146 90415944
Aortic stenosis 48.29 10.40 66 208291 6270 90413820
Food interaction 47.68 10.40 32 208325 1232 90418858
Leukopenia 47.62 10.40 100 208257 100610 90319480
Heart valve replacement 47.25 10.40 27 208330 777 90419313
Osteoporosis 47.22 10.40 94 208263 96437 90323653
Embolism 47.13 10.40 81 208276 9400 90410690
Intentional overdose 47.09 10.40 90 208267 93744 90326346
Migraine 46.66 10.40 252 208105 190140 90229950
Transient ischaemic attack 46.65 10.40 210 208147 42966 90377124
Accidental overdose 46.47 10.40 157 208200 28116 90391974
Traumatic haematoma 46.11 10.40 36 208321 1759 90418331
Hip fracture 46.09 10.40 174 208183 32903 90387187
Blood creatinine increased 45.97 10.40 394 207963 100992 90319098
Cardiac valve disease 45.93 10.40 55 208302 4580 90415510
Product complaint 45.73 10.40 98 208259 13402 90406688
Spinal subdural haematoma 45.33 10.40 16 208341 138 90419952
Cardiomegaly 45.27 10.40 120 208237 18805 90401285
Catheter site discolouration 44.97 10.40 15 208342 107 90419983
Suicidal ideation 44.36 10.40 63 208294 73792 90346298
Eye haemorrhage 44.23 10.40 82 208275 10098 90409992
Colitis ulcerative 44.10 10.40 44 208313 60222 90359868
Headache 43.52 10.40 2411 205946 860335 89559755
Mucosal inflammation 43.41 10.40 41 208316 57584 90362506
Dizziness postural 43.25 10.40 76 208281 8977 90411113
International normalised ratio 43.22 10.40 14 208343 90 90420000
Liver disorder 43.10 10.40 139 208218 121130 90298960
Musculoskeletal pain 42.89 10.40 225 208132 171026 90249064
Disability 42.81 10.40 20 208337 40725 90379365
Haemothorax 42.54 10.40 39 208318 2379 90417711
Spinal cord haematoma 42.46 10.40 17 208340 214 90419876
Cerebral infarction 42.24 10.40 146 208211 26450 90393640
Ovarian haemorrhage 41.99 10.40 20 208337 391 90419699
Petechiae 41.99 10.40 104 208253 15637 90404453
Intestinal haematoma 41.84 10.40 14 208343 101 90419989
Cytokine release syndrome 41.79 10.40 7 208350 27966 90392124
Ear pain 41.24 10.40 43 208314 57659 90362431
Intracardiac thrombus 41.20 10.40 38 208319 2336 90417754
Device breakage 40.91 10.40 96 208261 13948 90406142
Haematochezia 40.67 10.40 291 208066 70622 90349468
Mineral supplementation 40.63 10.40 24 208333 736 90419354
Foetal warfarin syndrome 40.62 10.40 8 208349 0 90420090
Anticoagulation drug level decreased 40.60 10.40 12 208345 54 90420036
Haematoma evacuation 40.54 10.40 15 208342 150 90419940
Protein C decreased 40.44 10.40 11 208346 34 90420056
Cardiogenic shock 40.33 10.40 136 208221 24332 90395758
Cerebral mass effect 40.24 10.40 27 208330 1039 90419051
Adrenal haemorrhage 40.19 10.40 21 208336 504 90419586
COVID-19 39.99 10.40 226 208131 168617 90251473
Urinary tract infection 39.93 10.40 952 207405 304680 90115410
Drug monitoring procedure not performed 39.85 10.40 24 208333 763 90419327
Anovulatory cycle 39.85 10.40 15 208342 158 90419932
Anticoagulant-related nephropathy 39.84 10.40 10 208347 20 90420070
Renal impairment 39.38 10.40 393 207964 105028 90315062
Catheter site warmth 39.36 10.40 16 208341 210 90419880
Dilatation ventricular 39.25 10.40 37 208320 2339 90417751
Infusion site cellulitis 38.74 10.40 18 208339 332 90419758
Somnolence 38.42 10.40 685 207672 208399 90211691
Haemorrhagic diathesis 38.32 10.40 55 208302 5469 90414621
Insomnia 38.24 10.40 538 207819 332936 90087154
Weight increased 38.03 10.40 704 207653 417223 90002867
Extradural haematoma 37.64 10.40 34 208323 2034 90418056
Atrial thrombosis 37.16 10.40 35 208322 2210 90417880
Renal disorder 37.12 10.40 179 208178 37680 90382410
Vascular pseudoaneurysm ruptured 36.55 10.40 12 208345 81 90420009
Intestinal haemorrhage 36.46 10.40 48 208309 4399 90415691
Walking aid user 36.43 10.40 18 208339 35488 90384602
Injection site erythema 36.34 10.40 111 208246 98391 90321699
Infusion site haemorrhage 36.26 10.40 53 208304 5358 90414732
Cerebral haematoma 36.26 10.40 47 208310 4242 90415848
Multiple sclerosis relapse 36.24 10.40 40 208317 52265 90367825
Hepatitis 36.24 10.40 67 208290 70672 90349418
Catheter site vesicles 36.03 10.40 18 208339 392 90419698
Prothrombin consumption time prolonged 35.82 10.40 10 208347 35 90420055
Aortic valve replacement 35.73 10.40 24 208333 925 90419165
Catheter culture positive 35.56 10.40 14 208343 168 90419922
Pulmonary alveolar haemorrhage 34.88 10.40 55 208302 5943 90414147
Mitral valve disease 34.83 10.40 36 208321 2546 90417544
Dermatitis atopic 34.79 10.40 6 208351 23466 90396624
Emergency care 34.73 10.40 29 208328 1560 90418530
Drug abuse 34.70 10.40 87 208270 82260 90337830
Infusion site warmth 34.23 10.40 33 208324 2145 90417945
Sciatic nerve palsy 34.06 10.40 9 208348 24 90420066
Injection site swelling 34.03 10.40 53 208304 59786 90360304
Anxiety 34.02 10.40 504 207853 309268 90110822
Infusion site swelling 34.01 10.40 80 208277 11640 90408450
Arthritis 33.91 10.40 235 208122 167080 90253010
Condition aggravated 33.87 10.40 1077 207280 594468 89825622
Dyspepsia 33.76 10.40 292 208065 197868 90222222
Productive cough 33.64 10.40 297 208060 76766 90343324
Delirium 33.46 10.40 125 208232 104234 90315856
Protein S decreased 33.28 10.40 9 208348 27 90420063
Injection site pruritus 33.25 10.40 45 208312 53789 90366301
Breast haematoma 33.12 10.40 14 208343 204 90419886
Myxoedema coma 33.04 10.40 17 208340 395 90419695
Mediastinal haematoma 32.68 10.40 11 208346 81 90420009
Mouth haemorrhage 32.66 10.40 65 208292 8436 90411654
Calcium deficiency 32.66 10.40 26 208331 1307 90418783
Lung disorder 32.65 10.40 206 208151 149677 90270413
Vitamin K deficiency 32.50 10.40 18 208339 487 90419603
Application site pruritus 32.01 10.40 44 208313 4203 90415887
Hypophagia 31.77 10.40 165 208192 35772 90384318
Myalgia 31.55 10.40 572 207785 174553 90245537
Haemorrhagic ovarian cyst 31.31 10.40 20 208337 707 90419383
Prothrombin time shortened 31.16 10.40 32 208325 2246 90417844
Oxygen therapy 31.05 10.40 37 208320 3065 90417025
Bradyarrhythmia 30.85 10.40 33 208324 2428 90417662
Mental status changes 30.84 10.40 192 208165 44487 90375603
Central venous catheter removal 30.83 10.40 17 208340 456 90419634
Endocarditis 30.53 10.40 57 208300 7056 90413034
Prothrombin level abnormal 30.52 10.40 10 208347 67 90420023
Scleroderma 30.48 10.40 53 208304 6208 90413882
Device connection issue 30.07 10.40 22 208335 974 90419116
Drug level changed 30.06 10.40 13 208344 201 90419889
Electrocardiogram QT prolonged 29.97 10.40 276 208081 72180 90347910
Adverse drug reaction 29.96 10.40 152 208205 116549 90303541
Ear infection 29.96 10.40 73 208284 69702 90350388
Chronic obstructive pulmonary disease 29.92 10.40 280 208077 73549 90346541
Blood viscosity increased 29.85 10.40 14 208343 264 90419826
Disease complication 29.83 10.40 40 208317 3732 90416358
Blood potassium increased 29.62 10.40 110 208247 20639 90399451
Conjunctival haemorrhage 29.61 10.40 41 208316 3943 90416147
Atrioventricular block complete 29.60 10.40 68 208289 9743 90410347
Renal vascular thrombosis 29.55 10.40 10 208347 75 90420015
Therapeutic response shortened 29.54 10.40 8 208349 22871 90397219
Iron deficiency anaemia 29.35 10.40 120 208237 23542 90396548
Blood urea increased 29.25 10.40 143 208214 30270 90389820
Skin exfoliation 29.20 10.40 71 208286 67842 90352248
Illness 29.09 10.40 94 208263 81875 90338215
Nasopharyngitis 29.07 10.40 713 207644 406391 90013699
Back injury 28.77 10.40 39 208318 46583 90373507
Subdural haematoma evacuation 28.65 10.40 8 208349 28 90420062
Heavy menstrual bleeding 28.61 10.40 108 208249 20422 90399668
Oedema 28.34 10.40 631 207726 199664 90220426
Device dislocation 28.14 10.40 145 208212 31337 90388753
Exercise tolerance decreased 28.13 10.40 57 208300 7494 90412596
Concomitant disease progression 28.11 10.40 30 208327 2202 90417888
Catarrh 28.06 10.40 26 208331 1608 90418482
Amnesia 28.04 10.40 141 208216 108364 90311726
Compartment syndrome 27.95 10.40 34 208323 2878 90417212
Atrial septal defect repair 27.92 10.40 13 208344 241 90419849
Aortic dissection 27.85 10.40 31 208326 2386 90417704
Chronic sinusitis 27.73 10.40 10 208347 23792 90396298
Cardiac flutter 27.63 10.40 43 208314 4595 90415495
Drug ineffective for unapproved indication 27.62 10.40 71 208286 66573 90353517
Embolic stroke 27.45 10.40 40 208317 4032 90416058
Breast necrosis 27.26 10.40 12 208345 194 90419896
Pyrexia 27.24 10.40 1241 207116 659244 89760846
No adverse event 26.98 10.40 74 208283 67908 90352182
Shock 26.74 10.40 134 208223 28644 90391446
Abdominal distension 26.56 10.40 435 207922 130166 90289924
Hydrocephalus 26.36 10.40 49 208308 6045 90414045
Rheumatoid nodule 26.13 10.40 7 208350 20159 90399931
Endarterectomy 26.04 10.40 12 208345 217 90419873
Thyroid haemorrhage 25.98 10.40 9 208348 73 90420017
Coagulation time shortened 25.92 10.40 11 208346 162 90419928
Protein S deficiency 25.89 10.40 7 208350 21 90420069
Incorrect route of product administration 25.89 10.40 48 208309 50578 90369512
Mitral valve incompetence 25.43 10.40 111 208246 22413 90397677
Subarachnoid haematoma 25.41 10.40 7 208350 23 90420067
Adverse event 25.25 10.40 162 208195 117256 90302834
Gastrointestinal arteriovenous malformation 25.22 10.40 16 208341 559 90419531
Stent placement 25.08 10.40 39 208318 4164 90415926
Right ventricular dysfunction 25.00 10.40 29 208328 2335 90417755
Cardioactive drug level decreased 24.97 10.40 9 208348 83 90420007
Hypoglycaemia 24.94 10.40 258 208099 69590 90350500
Catheter site dermatitis 24.87 10.40 9 208348 84 90420006
Walking distance test abnormal 24.77 10.40 16 208341 577 90419513
Proctitis 24.71 10.40 3 208354 15256 90404834
Hypoprothrombinaemia 24.56 10.40 14 208343 401 90419689
Food allergy 24.54 10.40 14 208343 25464 90394626
Influenza 24.42 10.40 453 207904 138811 90281279
Device related thrombosis 24.38 10.40 27 208330 2066 90418024
Drug dependence 24.37 10.40 19 208338 29308 90390782
Pulmonary arterial pressure abnormal 24.35 10.40 16 208341 594 90419496
Infusion site discharge 24.30 10.40 29 208328 2406 90417684
Muscle spasms 24.24 10.40 420 207937 251463 90168627
Coagulation factor decreased 24.23 10.40 11 208346 192 90419898
Mitral valve stenosis 24.07 10.40 22 208335 1337 90418753
Sinus node dysfunction 24.02 10.40 44 208313 5368 90414722
Catheter site nodule 23.99 10.40 8 208349 57 90420033
Oral herpes 23.93 10.40 25 208332 33499 90386591
Procedural pain 23.68 10.40 25 208332 33335 90386755
Retching 23.63 10.40 97 208260 19062 90401028
Female genital tract fistula 23.54 10.40 6 208351 17862 90402228
General symptom 23.47 10.40 3 208354 14665 90405425
Urine output decreased 23.43 10.40 73 208284 12530 90407560
Blood pressure systolic decreased 23.42 10.40 60 208297 9210 90410880
Clostridium difficile infection 23.31 10.40 153 208204 36092 90383998
Tricuspid valve incompetence 23.30 10.40 88 208269 16643 90403447
Atrioventricular block 23.26 10.40 58 208299 8757 90411333
Abdominal cavity drainage 23.22 10.40 14 208343 446 90419644
Infusion site abscess 23.14 10.40 13 208344 362 90419728
Femoral nerve palsy 23.05 10.40 5 208352 3 90420087
Cor pulmonale 23.01 10.40 26 208331 2034 90418056
Nephrogenic systemic fibrosis 22.97 10.40 37 208320 4071 90416019
Nephrosclerosis 22.83 10.40 20 208337 1149 90418941
Infusion site pruritus 22.79 10.40 49 208308 6716 90413374
Abdominal wall haemorrhage 22.64 10.40 10 208347 163 90419927
Sedation 22.63 10.40 48 208309 48123 90371967
Confusional state 22.51 10.40 696 207661 385509 90034581
Drug therapy 22.48 10.40 17 208340 792 90419298
Spinal subarachnoid haemorrhage 22.46 10.40 5 208352 4 90420086
Hepatorenal failure 22.42 10.40 16 208341 681 90419409
Angiodysplasia 22.40 10.40 16 208341 682 90419408
Gait disturbance 22.38 10.40 443 207914 260053 90160037
Anticoagulant therapy 22.33 10.40 17 208340 800 90419290
Cardiac pacemaker replacement 22.23 10.40 13 208344 391 90419699
Infusion site irritation 22.22 10.40 21 208336 1332 90418758
Blood culture positive 22.21 10.40 41 208316 5031 90415059
Hepatic cytolysis 22.13 10.40 23 208334 30893 90389197
Skin discolouration 22.11 10.40 176 208181 44139 90375951
Gastric antral vascular ectasia 22.11 10.40 17 208340 812 90419278
Serotonin syndrome 22.08 10.40 33 208324 37854 90382236
Neutrophil count decreased 22.07 10.40 87 208270 71445 90348645
Prothrombin level increased 22.03 10.40 12 208345 314 90419776
Left ventricular failure 21.96 10.40 48 208309 6652 90413438
Balloon atrial septostomy 21.89 10.40 8 208349 77 90420013
Acute myeloid leukaemia 21.88 10.40 10 208347 20630 90399460
Accidental exposure to product 21.81 10.40 40 208317 42326 90377764
Heart valve operation 21.80 10.40 10 208347 179 90419911
Foetal exposure during pregnancy 21.75 10.40 41 208316 42934 90377156
Sedation complication 21.73 10.40 6 208351 16938 90403152
Product quality issue 21.70 10.40 101 208256 79224 90340866
Mitral valve repair 21.60 10.40 11 208346 250 90419840
Duodenal ulcer haemorrhage 21.59 10.40 28 208329 2528 90417562
Cardiac tamponade 21.56 10.40 43 208314 5589 90414501
Basal cell carcinoma 21.56 10.40 27 208330 33362 90386728
Anticoagulation drug level abnormal 21.55 10.40 9 208348 127 90419963
Oral mucosa haematoma 21.46 10.40 5 208352 6 90420084
Adverse reaction 21.39 10.40 22 208335 29690 90390400
Dizziness exertional 21.35 10.40 14 208343 518 90419572
Blood culture negative 21.16 10.40 10 208347 192 90419898
Colitis 20.99 10.40 86 208271 69856 90350234
Ovarian rupture 20.98 10.40 7 208350 50 90420040
Ovarian cyst ruptured 20.96 10.40 21 208336 1431 90418659
Eschar 20.88 10.40 15 208342 645 90419445
Venous thrombosis 20.87 10.40 42 208315 5495 90414595
Vaginal haematoma 20.82 10.40 9 208348 139 90419951
Intentional self-injury 20.80 10.40 22 208335 29312 90390778
Rash vesicular 20.60 10.40 8 208349 18189 90401901
Pulmonary calcification 20.50 10.40 11 208346 279 90419811
Burns second degree 20.45 10.40 24 208333 1956 90418134
Hepatotoxicity 20.45 10.40 47 208310 45795 90374295
Catheter site oedema 20.40 10.40 7 208350 55 90420035
Tracheal calcification 20.31 10.40 4 208353 0 90420090
Valvuloplasty cardiac 20.31 10.40 4 208353 0 90420090
Uterine haemorrhage 20.30 10.40 38 208319 4714 90415376
Purple glove syndrome 20.26 10.40 10 208347 212 90419878
Extrasystoles 20.24 10.40 42 208315 5615 90414475
Parosmia 20.24 10.40 48 208309 7021 90413069
Rales 20.21 10.40 81 208276 15746 90404344
Spondylitis 20.21 10.40 4 208353 14174 90405916
Dry eye 20.16 10.40 67 208290 57864 90362226
Post procedural haematoma 20.10 10.40 20 208337 1352 90418738
Suicide attempt 20.04 10.40 97 208260 75302 90344788
Blue toe syndrome 20.02 10.40 13 208344 473 90419617
Heart sounds abnormal 20.00 10.40 15 208342 690 90419400
Jugular vein distension 19.96 10.40 18 208339 1075 90419015
Multiple injuries 19.92 10.40 23 208334 1842 90418248
Memory impairment 19.92 10.40 326 208031 196918 90223172
Blood sodium decreased 19.90 10.40 120 208237 27493 90392597
Venous pressure jugular increased 19.82 10.40 14 208343 586 90419504
Catheter site dryness 19.78 10.40 6 208351 30 90420060
Arteriovenous malformation 19.76 10.40 21 208336 1534 90418556
Cerebellar haematoma 19.74 10.40 12 208345 388 90419702
Ventricular fibrillation 19.67 10.40 74 208283 13970 90406120
Catheter site urticaria 19.62 10.40 6 208351 31 90420059
Colonoscopy 19.50 10.40 22 208335 1718 90418372
Psychotic disorder 19.39 10.40 26 208331 31204 90388886
Device difficult to use 19.36 10.40 8 208349 17517 90402573
Mitral valve replacement 19.33 10.40 13 208344 502 90419588
Nocturnal dyspnoea 19.28 10.40 20 208337 1420 90418670
End stage renal disease 19.15 10.40 53 208304 8518 90411572
Device malfunction 19.02 10.40 97 208260 20880 90399210
Tongue necrosis 19.01 10.40 7 208350 69 90420021
Occult blood 19.00 10.40 19 208338 1292 90418798
Haemorrhagic cerebral infarction 18.99 10.40 14 208343 627 90419463
Exophthalmos 18.88 10.40 22 208335 1780 90418310
Angioplasty 18.86 10.40 20 208337 1457 90418633
Personality disorder 18.85 10.40 3 208354 12441 90407649
Therapy interrupted 18.81 10.40 56 208301 50052 90370038
Heart rate decreased 18.80 10.40 197 208160 53308 90366782
Affect lability 18.77 10.40 9 208348 18054 90402036
Infusion site oedema 18.76 10.40 18 208339 1163 90418927
Nausea 18.73 10.40 2866 205491 1107450 89312640
Product administration error 18.52 10.40 114 208243 26309 90393781
Hyperhomocysteinaemia 18.51 10.40 11 208346 341 90419749
Cerebral venous sinus thrombosis 18.49 10.40 25 208332 2351 90417739
Haemodialysis 18.47 10.40 53 208304 8694 90411396
Haemorrhagic ascites 18.42 10.40 8 208349 125 90419965
Endotracheal intubation 18.40 10.40 30 208327 3334 90416756
Analgesic therapy 18.40 10.40 14 208343 658 90419432
Haemolysis 18.40 10.40 52 208305 8458 90411632
Hypopnoea 18.39 10.40 35 208322 4396 90415694
Device physical property issue 18.33 10.40 27 208330 2749 90417341
Product substitution issue 18.28 10.40 86 208271 17922 90402168
Neuroleptic malignant syndrome 18.18 10.40 6 208351 15090 90405000
Dysentery 18.16 10.40 17 208340 1065 90419025
Periorbital haematoma 18.14 10.40 15 208342 796 90419294
Paraplegia 18.09 10.40 30 208327 3382 90416708
Carotid artery occlusion 18.09 10.40 43 208314 6299 90413791
Terminal state 18.02 10.40 27 208330 2791 90417299
Fatigue 18.00 10.40 2352 206005 1151671 89268419
Platelet count decreased 17.97 10.40 427 207930 136542 90283548
Generalised tonic-clonic seizure 17.93 10.40 33 208324 34870 90385220
Subcapsular renal haematoma 17.93 10.40 11 208346 362 90419728
Infected skin ulcer 17.88 10.40 26 208331 2616 90417474
Schizophrenia 17.83 10.40 6 208351 14908 90405182
Hypovolaemia 17.82 10.40 66 208291 12365 90407725
Pulseless electrical activity 17.79 10.40 53 208304 8879 90411211
Oral candidiasis 17.79 10.40 34 208323 35421 90384669
Frequent bowel movements 17.72 10.40 69 208288 56866 90363224
Infusion site reaction 17.58 10.40 11 208346 19028 90401062
Splenic haemorrhage 17.57 10.40 9 208348 207 90419883
Diastolic hypotension 17.56 10.40 7 208350 87 90420003
Coma scale normal 17.55 10.40 4 208353 4 90420086
Extremity necrosis 17.42 10.40 22 208335 1935 90418155
Application site irritation 17.38 10.40 22 208335 1939 90418151
Gastritis erosive 17.35 10.40 44 208313 6711 90413379
Gastric ulcer haemorrhage 17.35 10.40 38 208319 5273 90414817
Therapeutic product effect increased 17.32 10.40 18 208339 1281 90418809
Metastases to lymph nodes 17.30 10.40 3 208354 11686 90408404
Heart transplant 17.29 10.40 13 208344 600 90419490
Procedural haemorrhage 17.28 10.40 28 208329 3096 90416994
Lip haemorrhage 17.28 10.40 13 208344 601 90419489
Overdose 17.27 10.40 480 207877 157229 90262861
Neoplasm progression 17.23 10.40 49 208308 44437 90375653
Drain placement 17.14 10.40 7 208350 93 90419997
Hyponatraemia 17.12 10.40 415 207942 133123 90286967
Cardiac output decreased 17.07 10.40 16 208341 1004 90419086
Hiatus hernia strangulated 17.07 10.40 10 208347 302 90419788
Kidney infection 17.03 10.40 110 208247 25806 90394284
Dermatomyositis 17.03 10.40 29 208328 3341 90416749
Lacrimal haemorrhage 17.01 10.40 5 208352 22 90420068
Blood glucose decreased 17.00 10.40 102 208255 23327 90396763
Antacid therapy 16.98 10.40 14 208343 740 90419350
Thrombectomy 16.97 10.40 9 208348 223 90419867
Vaginal discharge 16.96 10.40 12 208345 19452 90400638
Respiratory distress 16.94 10.40 150 208207 38796 90381294
Appendicolith 16.87 10.40 14 208343 747 90419343
Chest discomfort 16.84 10.40 427 207930 137938 90282152
Catheter site mass 16.83 10.40 5 208352 23 90420067
Thoracic haemorrhage 16.77 10.40 6 208351 54 90420036
Palmar-plantar erythrodysaesthesia syndrome 16.73 10.40 24 208333 27999 90392091
Skin fissures 16.64 10.40 14 208343 20795 90399295
Peripheral embolism 16.63 10.40 18 208339 1342 90418748
Localised oedema 16.60 10.40 41 208316 6153 90413937
Vascular stenosis 16.55 10.40 12 208345 524 90419566
Post procedural complication 16.53 10.40 87 208270 18955 90401135
Sinus bradycardia 16.51 10.40 80 208277 16872 90403218
Factor V inhibition 16.50 10.40 8 208349 163 90419927
Aplastic anaemia 16.47 10.40 5 208352 13264 90406826
Hepatic haematoma 16.47 10.40 12 208345 528 90419562
Brain operation 16.46 10.40 13 208344 646 90419444
Blood blister 16.45 10.40 23 208334 2232 90417858
Colon cancer 16.45 10.40 59 208298 10885 90409205
Nasal discharge discolouration 16.37 10.40 26 208331 2827 90417263
Pulmonary congestion 16.34 10.40 88 208269 19345 90400745
Diverticulum 16.28 10.40 63 208294 12050 90408040
Oesophageal compression 16.28 10.40 4 208353 7 90420083
Upper respiratory tract inflammation 16.23 10.40 25 208332 2647 90417443
Ankylosing spondylitis 16.20 10.40 5 208352 13128 90406962
Chordae tendinae rupture 16.17 10.40 5 208352 27 90420063
Large intestinal polypectomy 16.11 10.40 10 208347 336 90419754
Macular degeneration 16.08 10.40 40 208317 37930 90382160
Inferior vena caval occlusion 16.02 10.40 5 208352 28 90420062
Hepatic infarction 16.00 10.40 13 208344 673 90419417
Diverticulum intestinal haemorrhagic 16.00 10.40 20 208337 1741 90418349
Catheter site erosion 15.96 10.40 6 208351 63 90420027
Blood alkaline phosphatase increased 15.95 10.40 175 208182 47904 90372186
Aphthous ulcer 15.95 10.40 10 208347 17277 90402813
Anti factor V antibody positive 15.93 10.40 4 208353 8 90420082
Investigation 15.91 10.40 19 208338 1578 90418512
Chronic kidney disease 15.88 10.40 181 208176 50010 90370080
Prothrombin level decreased 15.87 10.40 13 208344 681 90419409
Injection site urticaria 15.83 10.40 11 208346 18000 90402090
Eosinophil cationic protein increased 15.79 10.40 6 208351 65 90420025
Poor peripheral circulation 15.73 10.40 31 208326 3994 90416096
Haematoma infection 15.72 10.40 13 208344 690 90419400
Duodenal ulcer 15.66 10.40 53 208304 9499 90410591
Nasal polyps 15.65 10.40 3 208354 10877 90409213
Coagulation time abnormal 15.63 10.40 6 208351 67 90420023
Factor VIII deficiency 15.62 10.40 4 208353 9 90420081
Implantable defibrillator insertion 15.59 10.40 12 208345 574 90419516
Multiple organ dysfunction syndrome 15.56 10.40 232 208125 68104 90351986
Nodal rhythm 15.49 10.40 20 208337 1798 90418292
Therapy non-responder 15.48 10.40 221 208136 136483 90283607
Heart rate abnormal 15.45 10.40 39 208318 5932 90414158
Right ventricular systolic pressure increased 15.43 10.40 12 208345 583 90419507
Pulmonary artery dilatation 15.42 10.40 10 208347 363 90419727
Lupus endocarditis 15.41 10.40 9 208348 270 90419820
Aspartate aminotransferase increased 15.41 10.40 327 208030 102610 90317480
Panniculitis 15.34 10.40 7 208350 14451 90405639
Purpura 15.31 10.40 71 208286 14707 90405383
Wrong technique in product usage process 15.26 10.40 99 208258 71472 90348618
Iris haemorrhage 15.23 10.40 3 208354 0 90420090
Acquired cardiac septal defect 15.23 10.40 3 208354 0 90420090
Acquired protein S deficiency 15.23 10.40 3 208354 0 90420090
Cardiac pacemaker adjustment 15.23 10.40 3 208354 0 90420090
Hepatic artery embolism 15.23 10.40 3 208354 0 90420090
Unresponsive to stimuli 15.15 10.40 144 208213 37977 90382113
Dystonia 15.15 10.40 10 208347 16809 90403281
Pulse absent 15.10 10.40 39 208318 6016 90414074
Incision site haemorrhage 15.03 10.40 12 208345 606 90419484
Product dose omission in error 14.96 10.40 15 208342 20488 90399602
Facial pain 14.91 10.40 65 208292 13117 90406973
Sudden death 14.88 10.40 57 208300 10852 90409238
Haemorrhagic hepatic cyst 14.83 10.40 5 208352 37 90420053
Right ventricular enlargement 14.76 10.40 11 208346 501 90419589
Concomitant disease aggravated 14.75 10.40 59 208298 11459 90408631
Pancreatitis 14.68 10.40 97 208260 69729 90350361
Plasma cell myeloma 14.66 10.40 151 208206 40677 90379413
Aspiration pleural cavity 14.63 10.40 14 208343 902 90419188
Sickle cell anaemia 14.62 10.40 12 208345 630 90419460
Drug resistance 14.59 10.40 30 208327 30419 90389671
Poisoning deliberate 14.58 10.40 10 208347 16476 90403614
Gravitational oedema 14.57 10.40 16 208341 1213 90418877
Product storage error 14.56 10.40 15 208342 20226 90399864
Venous haemorrhage 14.51 10.40 9 208348 302 90419788
Abdominal compartment syndrome 14.50 10.40 13 208344 770 90419320
Finger deformity 14.45 10.40 34 208323 32863 90387227
Supraventricular tachycardia 14.43 10.40 75 208282 16261 90403829
Pelvic haemorrhage 14.42 10.40 7 208350 143 90419947
Chronic respiratory failure 14.40 10.40 24 208333 2717 90417373
Large intestinal haemorrhage 14.37 10.40 18 208339 1570 90418520
Hospice care 14.32 10.40 52 208305 9652 90410438
Arterial thrombosis 14.26 10.40 18 208339 1582 90418508
Biopsy liver 14.24 10.40 10 208347 415 90419675
Squamous cell carcinoma of the oral cavity 14.21 10.40 10 208347 416 90419674
Finger amputation 14.21 10.40 12 208345 656 90419434
Rehabilitation therapy 14.20 10.40 20 208337 1954 90418136
Renal haemorrhage 14.14 10.40 15 208342 1093 90418997
Breast haemorrhage 14.10 10.40 8 208349 227 90419863
Oliguria 14.07 10.40 55 208302 10569 90409521
Low cardiac output syndrome 14.07 10.40 10 208347 423 90419667
Vascular stent thrombosis 14.05 10.40 15 208342 1101 90418989
Haemorrhage urinary tract 14.04 10.40 15 208342 1102 90418988
Injection site discharge 14.02 10.40 17 208340 1434 90418656
Renal stone removal 13.99 10.40 7 208350 153 90419937
Traumatic intracranial haemorrhage 13.98 10.40 12 208345 671 90419419
Localised infection 13.95 10.40 128 208229 33434 90386656
Diet noncompliance 13.92 10.40 10 208347 430 90419660
Polyarthritis 13.89 10.40 13 208344 18337 90401753
Arteriovenous fistula site haemorrhage 13.85 10.40 8 208349 235 90419855
Medical device implantation 13.82 10.40 12 208345 681 90419409
Transcatheter aortic valve implantation 13.79 10.40 5 208352 47 90420043
Intra-abdominal fluid collection 13.75 10.40 24 208333 2820 90417270
Increased tendency to bruise 13.73 10.40 59 208298 11831 90408259
Incarcerated umbilical hernia 13.72 10.40 4 208353 17 90420073
Blood urine present 13.69 10.40 77 208280 17201 90402889
Paracentesis 13.65 10.40 14 208343 981 90419109
Hyponatraemic syndrome 13.65 10.40 11 208346 563 90419527
Respiratory disorder 13.64 10.40 90 208267 64726 90355364
Thyroiditis acute 13.63 10.40 6 208351 97 90419993
Mallory-Weiss syndrome 13.61 10.40 18 208339 1657 90418433
Dental restoration failure 13.53 10.40 15 208342 1149 90418941
Tri-iodothyronine increased 13.52 10.40 8 208349 246 90419844
Arteriovenous fistula operation 13.49 10.40 8 208349 247 90419843
Inappropriate schedule of product administration 13.47 10.40 253 208104 149680 90270410
Steroid dependence 13.46 10.40 21 208336 2248 90417842
Tuberculosis 13.43 10.40 6 208351 12543 90407547
Pneumocystis jirovecii pneumonia 13.42 10.40 18 208339 21598 90398492
Chronic cutaneous lupus erythematosus 13.38 10.40 13 208344 853 90419237
Oxygen consumption 13.36 10.40 6 208351 102 90419988
Heart valve incompetence 13.27 10.40 26 208331 3336 90416754
Spontaneous haemorrhage 13.24 10.40 12 208345 721 90419369
Catheter site hypersensitivity 13.20 10.40 6 208351 105 90419985
Mitral valve calcification 13.18 10.40 15 208342 1183 90418907
Hyphaema 13.17 10.40 9 208348 357 90419733
Brachiocephalic vein thrombosis 13.15 10.40 6 208351 106 90419984
Gestational diabetes 13.11 10.40 4 208353 10578 90409512
Pruritus genital 13.10 10.40 31 208326 4527 90415563
Transaminases abnormal 13.10 10.40 12 208345 731 90419359
Infusion site induration 13.05 10.40 17 208340 1542 90418548
Limb injury 13.02 10.40 120 208237 31388 90388702
Leg amputation 13 10.40 21 208336 2316 90417774
Motor dysfunction 13.00 10.40 15 208342 19215 90400875
Intentional dose omission 12.99 10.40 13 208344 17770 90402320
Haemorrhoidal haemorrhage 12.98 10.40 34 208323 5289 90414801
Cytomegalovirus infection 12.92 10.40 26 208331 26576 90393514
Coronary artery bypass 12.92 10.40 21 208336 2328 90417762
Colon operation 12.91 10.40 10 208347 483 90419607
Spinal cord haemorrhage 12.88 10.40 8 208349 269 90419821
Right atrial dilatation 12.88 10.40 12 208345 747 90419343
Staphylococcal infection 12.86 10.40 169 208188 48270 90371820
Multiple sclerosis 12.86 10.40 28 208329 27812 90392278
Cardiospasm 12.82 10.40 26 208331 3420 90416670
Thromboembolectomy 12.78 10.40 5 208352 59 90420031
Coagulation factor deficiency 12.78 10.40 5 208352 59 90420031
Gangrene 12.71 10.40 61 208296 12815 90407275
Visual impairment 12.63 10.40 221 208136 132144 90287946
Maternal exposure before pregnancy 12.58 10.40 5 208352 11208 90408882
Blood disorder 12.57 10.40 43 208314 7747 90412343
Biopsy liver abnormal 12.57 10.40 8 208349 281 90419809
Injection site warmth 12.57 10.40 13 208344 17502 90402588
Pharyngeal haematoma 12.55 10.40 5 208352 62 90420028
Polyuria 12.52 10.40 51 208306 9989 90410101
Intracranial haematoma 12.45 10.40 9 208348 391 90419699
Vascular calcification 12.45 10.40 12 208345 780 90419310
Blindness 12.43 10.40 104 208253 26464 90393626
Vessel puncture site haemorrhage 12.43 10.40 6 208351 121 90419969
Vascular injury 12.38 10.40 14 208343 1096 90418994
Bedridden 12.32 10.40 58 208299 12090 90408000
Drug eruption 12.29 10.40 41 208316 35366 90384724
Injection site rash 12.29 10.40 23 208334 24150 90395940
Injection site pustule 12.25 10.40 6 208351 125 90419965
Pulmonary arterial wedge pressure increased 12.25 10.40 9 208348 401 90419689
Eye injury 12.22 10.40 5 208352 11015 90409075
Human ehrlichiosis 12.20 10.40 7 208350 203 90419887
Cerebellar infarction 12.17 10.40 20 208337 2238 90417852
Angina bullosa haemorrhagica 12.17 10.40 6 208351 127 90419963
Mechanical ventilation 12.16 10.40 16 208341 1466 90418624
Abdominal tenderness 12.13 10.40 48 208309 9276 90410814
Drug level increased 12.11 10.40 107 208250 27655 90392435
Pallor 12.10 10.40 126 208231 34039 90386051
Tendonitis 12.09 10.40 19 208338 21353 90398737
Carotid artery thrombosis 12.08 10.40 3 208354 9089 90411001
Aortic thrombosis 12.08 10.40 15 208342 1297 90418793
Aortic surgery 12.06 10.40 4 208353 28 90420062
Cardiac resynchronisation therapy 12.06 10.40 4 208353 28 90420062
Walking disability 12.05 10.40 16 208341 1479 90418611
Aortic arteriosclerosis 12.04 10.40 42 208315 7642 90412448
Change of bowel habit 12.00 10.40 20 208337 2263 90417827
Altered state of consciousness 11.99 10.40 118 208239 31414 90388676
Infusion site haematoma 11.97 10.40 8 208349 306 90419784
Obstructive airways disorder 11.96 10.40 26 208331 25843 90394247
Brain stem haemorrhage 11.96 10.40 12 208345 819 90419271
Renal cell carcinoma 11.96 10.40 27 208330 3824 90416266
Thrombotic stroke 11.94 10.40 10 208347 540 90419550
Haematotoxicity 11.91 10.40 7 208350 12528 90407562
Radiculopathy 11.91 10.40 15 208342 18490 90401600
Tumour haemorrhage 11.90 10.40 19 208338 2075 90418015
Subchorionic haematoma 11.87 10.40 6 208351 134 90419956
Pain in extremity 11.86 10.40 1196 207161 449333 89970757
Catheter site extravasation 11.83 10.40 9 208348 423 90419667
Suture insertion 11.83 10.40 8 208349 312 90419778
Diuretic therapy 11.71 10.40 6 208351 138 90419952
Echocardiogram 11.71 10.40 4 208353 31 90420059
Cockroach allergy 11.70 10.40 5 208352 75 90420015
Hypomania 11.70 10.40 3 208354 8894 90411196
Intravascular haemolysis 11.68 10.40 9 208348 431 90419659
Pupil fixed 11.67 10.40 19 208338 2109 90417981
Hyperthyroidism 11.60 10.40 77 208280 18233 90401857
Hyperaesthesia 11.52 10.40 52 208305 10650 90409440
Abortion 11.50 10.40 22 208335 2773 90417317
Inadequate diet 11.47 10.40 7 208350 228 90419862
Cerebral artery thrombosis 11.43 10.40 9 208348 445 90419645
Myocarditis 11.40 10.40 9 208348 13797 90406293
Pituitary infarction 11.38 10.40 4 208353 34 90420056
Bronchopulmonary aspergillosis 11.36 10.40 6 208351 11392 90408698
Palmoplantar keratoderma 11.35 10.40 25 208332 3482 90416608
Maxillonasal dysplasia 11.35 10.40 3 208354 8 90420082
Medical device site thrombosis 11.35 10.40 5 208352 81 90420009
Post thrombotic syndrome 11.33 10.40 10 208347 580 90419510
Seasonal allergy 11.31 10.40 91 208266 22892 90397198
Abnormal loss of weight 11.31 10.40 38 208319 6785 90413305
Catheter site cellulitis 11.28 10.40 8 208349 337 90419753
Brain natriuretic peptide 11.28 10.40 4 208353 35 90420055
Factor XIII Inhibition 11.28 10.40 4 208353 35 90420055
Injection site haemorrhage 11.27 10.40 107 208250 28211 90391879
Postpartum haemorrhage 11.27 10.40 20 208337 2381 90417709
Ear haemorrhage 11.23 10.40 16 208341 1580 90418510
Hernia obstructive 11.23 10.40 6 208351 151 90419939
Cardiac murmur 11.22 10.40 76 208281 18118 90401972
Thyrotoxic crisis 11.21 10.40 14 208343 1217 90418873
Uveitis 11.19 10.40 12 208345 15891 90404199
Pulmonary arterial pressure decreased 11.13 10.40 5 208352 85 90420005
Phlebitis 11.12 10.40 40 208317 7390 90412700
Wound haemorrhage 11.11 10.40 22 208335 2845 90417245
Arteriovenous graft site haemorrhage 11.10 10.40 3 208354 9 90420081
Iliac artery embolism 11.10 10.40 3 208354 9 90420081
Breast hypoplasia 11.10 10.40 3 208354 9 90420081
Cardiac function disturbance postoperative 11.09 10.40 4 208353 37 90420053
Application site odour 11.09 10.40 4 208353 37 90420053
Emergency care examination 11.08 10.40 6 208351 155 90419935
Hypertransaminasaemia 11.07 10.40 12 208345 15813 90404277
Abdominal pain upper 11.01 10.40 639 207718 332035 90088055
Jugular vein thrombosis 11.00 10.40 25 208332 3556 90416534
Gastrointestinal toxicity 10.99 10.40 4 208353 9463 90410627
Pulmonary infarction 10.98 10.40 22 208335 2870 90417220
Skin reaction 10.97 10.40 16 208341 18537 90401553
Upper limb fracture 10.93 10.40 86 208271 21492 90398598
Infusion site discolouration 10.92 10.40 13 208344 1076 90419014
Blood pressure abnormal 10.91 10.40 80 208277 19565 90400525
Infusion site pustule 10.90 10.40 4 208353 39 90420051
Colectomy 10.90 10.40 24 208333 3343 90416747
Post herpetic neuralgia 10.89 10.40 21 208336 2663 90417427
Nasal septum ulceration 10.86 10.40 3 208354 10 90420080
Cardioactive drug level below therapeutic 10.86 10.40 3 208354 10 90420080
Aortic valve repair 10.86 10.40 3 208354 10 90420080
Progressive multifocal leukoencephalopathy 10.81 10.40 12 208345 15643 90404447
Gastrointestinal endoscopic therapy 10.81 10.40 4 208353 40 90420050
Pancytopenia 10.78 10.40 203 208154 120060 90300030
Drug dose omission by device 10.78 10.40 5 208352 10226 90409864
Breast cancer female 10.74 10.40 11 208346 14875 90405215
Mucosal dryness 10.74 10.40 23 208334 3144 90416946
Catheter site scab 10.72 10.40 7 208350 257 90419833
Factor XIII deficiency 10.72 10.40 5 208352 93 90419997
Metastases to bone 10.70 10.40 27 208330 25478 90394612
Peripheral ischaemia 10.70 10.40 33 208324 5634 90414456
Vocal cord operation 10.68 10.40 5 208352 94 90419996
Conjunctivitis 10.65 10.40 29 208328 26677 90393413
5-hydroxyindolacetic acid increased 10.64 10.40 3 208354 11 90420079
Pulmonary vascular disorder 10.63 10.40 8 208349 370 90419720
N-terminal prohormone brain natriuretic peptide increased 10.61 10.40 22 208335 2940 90417150
Spinal cord compression 10.61 10.40 30 208327 4881 90415209
Acne 10.60 10.40 32 208325 28475 90391615
Insurance issue 10.59 10.40 6 208351 10952 90409138
Lymphopenia 10.58 10.40 23 208334 22858 90397232
Blood pressure immeasurable 10.56 10.40 15 208342 1477 90418613
Chest tube insertion 10.55 10.40 4 208353 43 90420047
Decreased activity 10.52 10.40 42 208315 8150 90411940
Metastases to central nervous system 10.50 10.40 15 208342 17527 90402563
Cardiopulmonary failure 10.47 10.40 27 208330 4161 90415929
Livedo reticularis 10.46 10.40 24 208333 3435 90416655
Gastric operation 10.46 10.40 8 208349 379 90419711
Postpartum venous thrombosis 10.43 10.40 3 208354 12 90420078
Radioactive iodine therapy 10.43 10.40 3 208354 12 90420078
Seizure 10.42 10.40 269 208088 152360 90267730

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 12402.11 11.18 5427 184066 42741 42389101
Gastric haemorrhage 2130.53 11.18 1006 188487 9509 42422333
Haemorrhage 2065.26 11.18 1888 187605 58675 42373167
International normalised ratio abnormal 1920.10 11.18 680 188813 2743 42429099
International normalised ratio decreased 1331.34 11.18 564 188929 4008 42427834
Gastrointestinal haemorrhage 1242.46 11.18 1831 187662 95895 42335947
Anticoagulation drug level above therapeutic 1167.69 11.18 438 189055 2152 42429690
Drug interaction 940.92 11.18 2961 186532 264038 42167804
Haematoma 822.80 11.18 805 188688 27218 42404624
Subdural haematoma 796.56 11.18 726 188767 22412 42409430
Haematuria 781.81 11.18 1116 188377 56683 42375159
Melaena 688.27 11.18 855 188638 37891 42393951
Haemorrhage intracranial 644.29 11.18 566 188927 16626 42415216
Anticoagulation drug level below therapeutic 587.39 11.18 207 189286 819 42431023
Epistaxis 569.13 11.18 1046 188447 65780 42366062
Off label use 499.19 11.18 1339 188154 636996 41794846
International normalised ratio fluctuation 490.05 11.18 194 189299 1130 42430712
Calciphylaxis 487.68 11.18 187 189306 986 42430856
Febrile neutropenia 465.95 11.18 125 189368 185578 42246264
Haemoglobin decreased 412.53 11.18 1411 188082 131060 42300782
Rectal haemorrhage 410.31 11.18 767 188726 48839 42383003
Cerebral haemorrhage 397.99 11.18 661 188832 38305 42393537
Prothrombin time prolonged 391.81 11.18 330 189163 9139 42422703
Labelled drug-drug interaction medication error 390.36 11.18 411 189082 15171 42416671
Anaemia 350.70 11.18 2287 187206 277991 42153851
Drug ineffective 338.99 11.18 1549 187944 628648 41803194
Cardiac failure congestive 311.55 11.18 962 188531 84640 42347202
Coagulopathy 290.66 11.18 422 189071 21740 42410102
Fall 256.35 11.18 1852 187641 232668 42199174
Muscle haemorrhage 247.23 11.18 179 189314 3946 42427896
Haemoptysis 237.55 11.18 589 188904 45578 42386264
Cardiac failure 222.33 11.18 1003 188490 105853 42325989
Neutropenia 219.64 11.18 342 189151 199089 42232753
Drug abuse 218.55 11.18 96 189397 104675 42327167
Pyrexia 218.54 11.18 956 188537 393086 42038756
Abdominal wall haematoma 217.30 11.18 133 189360 2189 42429653
Upper gastrointestinal haemorrhage 215.77 11.18 440 189053 29859 42401983
Retroperitoneal haematoma 212.15 11.18 145 189348 2906 42428936
Faeces discoloured 208.73 11.18 314 189179 16700 42415142
Subarachnoid haemorrhage 193.29 11.18 278 189215 14194 42417648
Contusion 180.56 11.18 501 188992 41484 42390358
Haematocrit decreased 180.22 11.18 446 189047 34462 42397380
Ecchymosis 172.30 11.18 192 189301 7560 42424282
Subdural haemorrhage 170.08 11.18 134 189359 3367 42428475
Cytokine release syndrome 164.39 11.18 8 189485 44519 42387323
Pulmonary arterial hypertension 162.13 11.18 213 189280 9974 42421868
Haematemesis 160.31 11.18 390 189103 29809 42402033
Retroperitoneal haemorrhage 160.29 11.18 124 189369 3031 42428811
Coagulation time prolonged 149.50 11.18 88 189405 1344 42430498
Foetal warfarin syndrome 141.45 11.18 32 189461 0 42431842
Atrial fibrillation 137.83 11.18 1077 188416 138516 42293326
Product use in unapproved indication 131.94 11.18 402 189091 184054 42247788
Fluid retention 131.70 11.18 373 189120 31246 42400596
Myelosuppression 122.85 11.18 17 189476 40444 42391398
Intra-abdominal haematoma 119.18 11.18 79 189414 1502 42430340
Haemarthrosis 117.52 11.18 115 189378 3883 42427959
Right ventricular failure 116.70 11.18 176 189317 9379 42422463
Lower gastrointestinal haemorrhage 113.85 11.18 186 189307 10622 42421220
Cerebrovascular accident 113.22 11.18 780 188713 96380 42335462
Mucosal inflammation 113.22 11.18 39 189454 49335 42382507
Anticoagulant-related nephropathy 113.19 11.18 38 189455 125 42431717
Therapeutic product effect incomplete 112.67 11.18 90 189403 70849 42360993
Malignant neoplasm progression 109.82 11.18 196 189297 108204 42323638
COVID-19 108.40 11.18 220 189273 115728 42316114
Deep vein thrombosis 107.60 11.18 647 188846 76310 42355532
Intraventricular haemorrhage 107.28 11.18 108 189385 3776 42428066
Occult blood positive 106.08 11.18 112 189381 4145 42427697
Pulmonary hypertension 105.03 11.18 285 189208 23284 42408558
Appendicolith 102.47 11.18 201 189292 13255 42418587
Head injury 101.01 11.18 258 189235 20324 42411518
Dyspnoea 100.65 11.18 2626 186867 439995 41991847
Transfusion 98.87 11.18 172 189321 10342 42421500
Haematoma muscle 97.42 11.18 79 189414 2071 42429771
Blood loss anaemia 93.81 11.18 161 189332 9575 42422267
Disease progression 89.06 11.18 333 189160 143323 42288519
Thrombosis 87.62 11.18 563 188930 67948 42363894
Cerebral mass effect 87.11 11.18 61 189432 1273 42430569
Leukopenia 85.21 11.18 125 189368 74621 42357221
Anaphylactic reaction 84.69 11.18 42 189451 42701 42389141
Hepatic cytolysis 84.59 11.18 10 189483 26834 42405008
Asthma 83.72 11.18 92 189401 62222 42369620
Ear haemorrhage 83.27 11.18 55 189438 1039 42430803
Infusion related reaction 80.34 11.18 91 189402 60715 42371127
Shock haemorrhagic 80.12 11.18 204 189289 16038 42415804
Oedema peripheral 79.52 11.18 940 188553 135136 42296706
Prothrombin time ratio increased 78.89 11.18 29 189464 133 42431709
Arthralgia 78.43 11.18 562 188931 204676 42227166
Cardiogenic shock 77.36 11.18 339 189154 35301 42396541
Intestinal haematoma 77.26 11.18 31 189462 188 42431654
Skin necrosis 76.68 11.18 116 189377 6198 42425644
Activated partial thromboplastin time prolonged 76.64 11.18 198 189295 15705 42416137
Drug dependence 75.89 11.18 18 189475 29076 42402766
Ventricular fibrillation 75.14 11.18 299 189194 29824 42402018
Gingival bleeding 74.87 11.18 135 189358 8350 42423492
Intentional overdose 74.76 11.18 71 189422 51385 42380457
Foetal exposure during pregnancy 73.89 11.18 61 189432 47250 42384592
Suicide attempt 73.80 11.18 58 189435 46042 42385800
Pancytopenia 73.57 11.18 272 189221 117471 42314371
Drug ineffective for unapproved indication 72.74 11.18 59 189434 46104 42385738
Neutrophil count decreased 72.33 11.18 106 189387 63309 42368533
Cardiac tamponade 72.22 11.18 115 189378 6425 42425417
Spinal epidural haematoma 71.83 11.18 36 189457 391 42431451
Dizziness 71.83 11.18 1529 187964 247725 42184117
Thrombocytopenia 71.74 11.18 523 188970 189756 42242086
Product use issue 71.39 11.18 146 189347 76605 42355237
Pain in jaw 71.38 11.18 182 189311 14320 42417522
Conjunctival haemorrhage 70.89 11.18 83 189410 3450 42428392
Heparin-induced thrombocytopenia 68.76 11.18 113 189380 6484 42425358
Agitation 68.11 11.18 113 189380 64201 42367641
Ventricular tachycardia 67.85 11.18 290 189203 29870 42401972
Appendicitis 66.99 11.18 223 189270 20390 42411452
Oedema 66.89 11.18 428 189065 51573 42380269
Therapy partial responder 66.85 11.18 6 189487 20015 42411827
Pruritus 66.37 11.18 529 188964 188242 42243600
Extradural haematoma 66.25 11.18 52 189441 1299 42430543
Stomatitis 64.68 11.18 77 189416 50252 42381590
Haemorrhagic stroke 64.33 11.18 117 189376 7285 42424557
Haematochezia 63.86 11.18 462 189031 57974 42373868
Injection site pain 63.61 11.18 99 189394 57699 42374143
Haemorrhage subcutaneous 63.08 11.18 68 189425 2578 42429264
Post procedural haemorrhage 62.48 11.18 132 189361 9180 42422662
Depression 60.92 11.18 271 189222 111092 42320750
Compartment syndrome 59.01 11.18 73 189420 3216 42428626
Rash maculo-papular 57.77 11.18 49 189444 37454 42394388
Acute myeloid leukaemia 57.59 11.18 14 189479 22242 42409600
Atrial flutter 57.29 11.18 188 189305 17063 42414779
Seizure 56.95 11.18 309 189184 120252 42311590
Hypervolaemia 56.44 11.18 228 189265 22897 42408945
Cerebellar haemorrhage 55.85 11.18 52 189441 1648 42430194
Blood phosphorus increased 55.34 11.18 151 189342 12374 42419468
Lymphopenia 54.95 11.18 14 189479 21549 42410293
Colitis 54.93 11.18 76 189417 46496 42385346
Scrotal haematoma 54.34 11.18 19 189474 73 42431769
Gastritis erosive 54.26 11.18 101 189392 6402 42425440
Traumatic haematoma 53.81 11.18 37 189456 749 42431093
Neoplasm progression 52.36 11.18 32 189461 28968 42402874
Product dose omission issue 51.31 11.18 439 189054 153926 42277916
Synovitis 51.08 11.18 5 189488 15562 42416280
Gastrointestinal arteriovenous malformation 50.89 11.18 27 189466 333 42431509
Chills 50.79 11.18 230 189263 93836 42338006
Anxiety 50.58 11.18 314 189179 118246 42313596
Transient ischaemic attack 50.57 11.18 289 189204 33450 42398392
Aggression 50.18 11.18 74 189419 44089 42387753
Cytomegalovirus infection 50.02 11.18 42 189451 32264 42399578
White blood cell count decreased 49.93 11.18 287 189206 110109 42321733
Cardiac failure chronic 49.88 11.18 123 189370 9478 42422364
Gastric ulcer 49.40 11.18 186 189307 18076 42413766
Device alarm issue 48.94 11.18 35 189458 756 42431086
Thrombosis in device 48.85 11.18 65 189428 3081 42428761
Device interaction 48.38 11.18 31 189462 555 42431287
Cholestasis 48.19 11.18 45 189448 32834 42399008
Syncope 47.98 11.18 663 188830 98743 42333099
Rheumatoid arthritis 47.36 11.18 72 189421 42368 42389474
Haemoperitoneum 47.34 11.18 52 189441 2014 42429828
Dyspnoea exertional 47.25 11.18 383 189110 49765 42382077
Gastric ulcer haemorrhage 47.22 11.18 92 189401 6035 42425807
Sleep disorder due to a general medical condition 47.12 11.18 10 189483 17443 42414399
Mallory-Weiss syndrome 47.06 11.18 45 189448 1476 42430366
International normalised ratio 46.73 11.18 15 189478 41 42431801
Hyperhidrosis 46.69 11.18 225 189268 90287 42341555
Renal haemorrhage 46.52 11.18 46 189447 1573 42430269
Mesenteric haematoma 46.25 11.18 13 189480 18 42431824
Steroid dependence 45.93 11.18 96 189397 6626 42425216
Chest wall haematoma 45.82 11.18 22 189471 216 42431626
Rash 45.81 11.18 912 188581 276042 42155800
Angioedema 45.56 11.18 74 189419 42403 42389439
Sedation 45.51 11.18 41 189452 30434 42401408
Accidental exposure to product 45.22 11.18 17 189476 20376 42411466
Bronchopulmonary aspergillosis 45.13 11.18 15 189478 19414 42412428
Pulmonary embolism 45.11 11.18 765 188728 118847 42312995
Generalised tonic-clonic seizure 45.05 11.18 31 189462 26348 42405494
Hemianopia homonymous 44.94 11.18 34 189459 803 42431039
Prostate cancer 44.92 11.18 81 189412 44562 42387280
Catheter management 44.83 11.18 37 189456 995 42430847
Abdominal distension 44.74 11.18 502 188991 71233 42360609
Serotonin syndrome 44.64 11.18 30 189463 25815 42406027
Mouth haemorrhage 44.64 11.18 91 189402 6170 42425672
Hypotension 44.48 11.18 1478 188015 256153 42175689
Burns second degree 43.93 11.18 89 189404 6007 42425835
Suicidal ideation 43.60 11.18 93 189400 48068 42383774
Psoriasis 43.06 11.18 95 189398 48509 42383333
Urticaria 43.04 11.18 176 189317 73860 42357982
Stress 42.92 11.18 340 189153 43872 42387970
Treatment failure 42.92 11.18 139 189354 62485 42369357
Subcutaneous haematoma 42.91 11.18 37 189456 1058 42430784
Psychotic disorder 42.78 11.18 40 189453 29168 42402674
Toxicity to various agents 42.07 11.18 741 188752 228395 42203447
Completed suicide 41.91 11.18 254 189239 96211 42335631
Dry skin 41.58 11.18 96 189397 48242 42383600
Catheter site erythema 41.28 11.18 45 189448 1728 42430114
Spontaneous haematoma 41.16 11.18 31 189462 727 42431115
Tumour lysis syndrome 40.88 11.18 24 189469 22207 42409635
Infection 40.30 11.18 312 189181 111756 42320086
Diabetic ketoacidosis 39.94 11.18 25 189468 22342 42409500
Medication error 39.66 11.18 268 189225 32886 42398956
Pancreatitis acute 39.35 11.18 55 189438 33509 42398333
Extrapyramidal disorder 39.32 11.18 12 189481 16400 42415442
Systemic lupus erythematosus 38.82 11.18 110 189383 9214 42422628
Cardiac failure acute 38.67 11.18 141 189352 13492 42418350
Penile necrosis 38.66 11.18 14 189479 61 42431781
Venous pressure jugular increased 38.47 11.18 30 189463 742 42431100
Pain 38.47 11.18 813 188680 244035 42187807
Septic shock 38.46 11.18 244 189249 91428 42340414
Cytomegalovirus infection reactivation 38.28 11.18 3 189490 11175 42420667
Hyphaema 38.11 11.18 29 189464 691 42431151
Psoriatic arthropathy 37.99 11.18 33 189460 24934 42406908
Lymphadenopathy 37.81 11.18 56 189437 33309 42398533
Pelvic haematoma 37.54 11.18 19 189474 211 42431631
Intracardiac thrombus 37.38 11.18 50 189443 2382 42429460
Prothrombin time abnormal 36.99 11.18 31 189462 852 42430990
No adverse event 36.46 11.18 74 189419 38947 42392895
Duodenal ulcer haemorrhage 36.29 11.18 80 189413 5728 42426114
COVID-19 pneumonia 36.12 11.18 26 189467 21587 42410255
Catarrh 35.78 11.18 81 189412 5905 42425937
Pericardial haemorrhage 35.68 11.18 60 189433 3509 42428333
Catheter site haemorrhage 35.57 11.18 50 189443 2498 42429344
Blood urine present 35.55 11.18 124 189369 11609 42420233
Internal haemorrhage 35.39 11.18 76 189417 5345 42426497
Lymphocyte count decreased 35.24 11.18 43 189450 27766 42404076
Hypercoagulation 35.24 11.18 38 189455 1441 42430401
Disturbance in attention 34.95 11.18 49 189444 29817 42402025
Traumatic intracranial haemorrhage 34.92 11.18 28 189465 722 42431120
Spinal subdural haematoma 34.79 11.18 13 189480 63 42431779
Diverticulum intestinal haemorrhagic 34.60 11.18 54 189439 2965 42428877
Sinusitis 34.51 11.18 102 189391 47190 42384652
Haemophagocytic lymphohistiocytosis 34.47 11.18 19 189474 18203 42413639
Thalamus haemorrhage 34.42 11.18 33 189460 1086 42430756
Hypokalaemia 34.30 11.18 183 189310 71538 42360304
Atrial thrombosis 34.18 11.18 48 189445 2396 42429446
Hepatocellular injury 34.00 11.18 33 189460 23645 42408197
Pneumocystis jirovecii pneumonia 34.00 11.18 37 189456 25144 42406698
Obstructive airways disorder 33.86 11.18 36 189457 24723 42407119
Laryngeal haematoma 33.51 11.18 16 189477 155 42431687
Pneumonitis 33.41 11.18 86 189407 41632 42390210
Posterior reversible encephalopathy syndrome 33.30 11.18 8 189485 12813 42419029
Haematoma evacuation 33.17 11.18 18 189475 233 42431609
Food interaction 33.07 11.18 31 189462 991 42430851
Cardiac pacemaker insertion 33.00 11.18 55 189438 3193 42428649
Cardiac murmur 32.82 11.18 128 189365 12647 42419195
Intentional product use issue 32.33 11.18 187 189306 71646 42360196
Restlessness 32.27 11.18 50 189443 29199 42402643
Aspergillus infection 32.22 11.18 15 189478 15822 42416020
Arteriovenous malformation 32.06 11.18 28 189465 815 42431027
Wheezing 31.97 11.18 130 189363 54651 42377191
Therapeutic product effect decreased 31.89 11.18 80 189413 39070 42392772
Blue toe syndrome 31.71 11.18 15 189478 142 42431700
Aplastic anaemia 31.63 11.18 8 189485 12376 42419466
Bronchiectasis 31.50 11.18 161 189332 17858 42413984
Alanine aminotransferase increased 31.36 11.18 247 189246 88159 42343683
Sopor 31.29 11.18 129 189364 13073 42418769
Asthenia 31.27 11.18 1537 187956 279256 42152586
Immune effector cell-associated neurotoxicity syndrome 31.15 11.18 3 189490 9458 42422384
Drug resistance 31.11 11.18 66 189427 34182 42397660
Neuropathy peripheral 31.05 11.18 296 189197 101557 42330285
Adrenal haemorrhage 31.02 11.18 19 189474 313 42431529
Hypertension 30.89 11.18 540 188953 166664 42265178
Neuroleptic malignant syndrome 30.75 11.18 30 189463 21442 42410400
Intentional product misuse 30.69 11.18 156 189337 61744 42370098
Insomnia 30.63 11.18 357 189136 117896 42313946
Pancreatitis 30.37 11.18 95 189398 43173 42388669
Blood uric acid increased 30.09 11.18 143 189350 15404 42416438
Coma 30.07 11.18 129 189364 53425 42378417
Small intestinal haemorrhage 30.03 11.18 44 189449 2284 42429558
Haemorrhagic diathesis 29.76 11.18 52 189441 3137 42428705
Implant site haematoma 29.47 11.18 13 189480 103 42431739
Hyperkalaemia 29.38 11.18 512 188981 79946 42351896
Hyperbilirubinaemia 29.35 11.18 29 189464 20606 42411236
Hypertriglyceridaemia 29.04 11.18 5 189488 10121 42421721
Musculoskeletal stiffness 28.97 11.18 145 189348 57620 42374222
Mediastinal haematoma 28.64 11.18 13 189480 111 42431731
Epilepsy 28.62 11.18 45 189448 26126 42405716
Catheter site discharge 28.59 11.18 26 189467 799 42431043
Diverticulum 28.55 11.18 86 189407 7455 42424387
Pulmonary alveolar haemorrhage 28.48 11.18 136 189357 14680 42417162
Oxygen consumption increased 28.45 11.18 36 189457 1623 42430219
Antiphospholipid syndrome 28.33 11.18 23 189470 604 42431238
Drug hypersensitivity 28.15 11.18 294 189199 99095 42332747
General physical health deterioration 28.08 11.18 488 189005 150758 42281084
Cardioversion 27.95 11.18 28 189465 973 42430869
Colonic haematoma 27.93 11.18 9 189484 25 42431817
Cytomegalovirus viraemia 27.90 11.18 6 189487 10371 42421471
Aortic stenosis 27.87 11.18 94 189399 8651 42423191
Alopecia 27.80 11.18 55 189438 29221 42402621
Embolic stroke 27.71 11.18 66 189427 4974 42426868
Atheroembolism 27.48 11.18 18 189475 335 42431507
Irritability 27.44 11.18 52 189441 28076 42403766
Hallucination, auditory 27.40 11.18 16 189477 14848 42416994
Exposure during pregnancy 27.39 11.18 3 189490 8545 42423297
Hypopnoea 27.16 11.18 87 189406 7795 42424047
Febrile bone marrow aplasia 27.14 11.18 6 189487 10175 42421667
Premature baby 27.08 11.18 38 189455 23115 42408727
Coagulation time shortened 27.06 11.18 15 189478 203 42431639
Nodule 26.88 11.18 11 189482 12523 42419319
Neutrophil count increased 26.85 11.18 29 189464 19775 42412067
Multiple sclerosis relapse 26.80 11.18 15 189478 14249 42417593
Duodenal ulcer 26.79 11.18 117 189376 12162 42419680
Choroidal haemorrhage 26.79 11.18 12 189481 99 42431743
Product administration error 26.75 11.18 156 189337 18187 42413655
Cardiac operation 26.69 11.18 54 189439 3641 42428201
Ascites 26.51 11.18 376 189117 56302 42375540
Congestive hepatopathy 26.46 11.18 42 189451 2340 42429502
Substance abuse 26.43 11.18 4 189489 8901 42422941
Mental status changes 26.37 11.18 295 189198 41820 42390022
Akathisia 26.22 11.18 7 189486 10444 42421398
Cerebral haematoma 26.16 11.18 69 189424 5541 42426301
Hypochromasia 26.07 11.18 17 189476 314 42431528
Abnormal behaviour 25.72 11.18 49 189444 26402 42405440
Therapeutic product effect increased 25.71 11.18 24 189469 763 42431079
Parosmia 25.70 11.18 84 189409 7607 42424235
Catheter site pruritus 25.65 11.18 17 189476 323 42431519
Renal haematoma 25.43 11.18 22 189471 632 42431210
Nephropathy 25.40 11.18 78 189415 6833 42425009
Product complaint 25.36 11.18 71 189422 5906 42425936
Hepatic steatosis 25.29 11.18 35 189458 21413 42410429
Hepatic enzyme increased 25.27 11.18 111 189382 45673 42386169
Gamma-glutamyltransferase increased 25.25 11.18 68 189425 32429 42399413
Sinus tachycardia 25.06 11.18 33 189460 20620 42411222
Cerebral artery embolism 24.99 11.18 27 189466 1026 42430816
Death 24.88 11.18 1782 187711 469403 41962439
Schizophrenia 24.76 11.18 8 189485 10542 42421300
Hypogammaglobulinaemia 24.60 11.18 11 189482 11880 42419962
Transplant rejection 24.52 11.18 15 189478 13573 42418269
Cytopenia 24.42 11.18 25 189468 17472 42414370
Frequent bowel movements 24.39 11.18 171 189322 21236 42410606
Medical device change 24.38 11.18 12 189481 125 42431717
Complication associated with device 24.18 11.18 75 189418 6606 42425236
Drug-induced liver injury 24.15 11.18 88 189405 38185 42393657
Hepatotoxicity 24.14 11.18 47 189446 25120 42406722
Cardioactive drug level increased 24.12 11.18 34 189459 1703 42430139
Hypocoagulable state 24.09 11.18 26 189467 987 42430855
Haemothorax 24.01 11.18 64 189429 5172 42426670
Medical device site thrombosis 23.90 11.18 8 189485 26 42431816
Haemorrhagic arteriovenous malformation 23.90 11.18 17 189476 364 42431478
Dyskinesia 23.85 11.18 48 189445 25342 42406500
C-reactive protein increased 23.76 11.18 175 189318 63385 42368457
Subarachnoid haematoma 23.73 11.18 15 189478 262 42431580
Bone marrow failure 23.69 11.18 72 189421 33021 42398821
Joint swelling 23.68 11.18 191 189302 67831 42364011
Rales 23.65 11.18 107 189386 11293 42420549
Rash erythematous 23.56 11.18 69 189424 32022 42399820
Obesity 23.56 11.18 23 189470 16436 42415406
Blood pressure fluctuation 23.50 11.18 53 189440 26855 42404987
Fat embolism 23.45 11.18 13 189480 176 42431666
Intraocular haematoma 23.31 11.18 7 189486 14 42431828
Inflammation 23.27 11.18 75 189418 33772 42398070
Paranoia 23.27 11.18 17 189476 14009 42417833
Immune reconstitution inflammatory syndrome 23.26 11.18 8 189485 10135 42421707
Drug reaction with eosinophilia and systemic symptoms 23.22 11.18 102 189391 41973 42389869
Haemorrhoidal haemorrhage 23.19 11.18 55 189438 4133 42427709
Acute generalised exanthematous pustulosis 23.05 11.18 5 189488 8590 42423252
Pharyngeal haematoma 22.91 11.18 10 189483 77 42431765
Tongue haematoma 22.91 11.18 11 189482 108 42431734
Hepatitis 22.85 11.18 55 189438 27245 42404597
Large intestinal haemorrhage 22.77 11.18 33 189460 1696 42430146
Platelet distribution width increased 22.55 11.18 12 189481 149 42431693
Heart valve replacement 22.45 11.18 18 189475 464 42431378
Lung transplant 22.39 11.18 39 189454 2347 42429495
Drug use disorder 22.27 11.18 9 189484 10324 42421518
Prothrombin level abnormal 22.27 11.18 10 189483 83 42431759
Blood pressure increased 22.22 11.18 319 189174 101609 42330233
Purpura 22.08 11.18 108 189385 11771 42420071
Catheter placement 22.03 11.18 24 189469 921 42430921
Prothrombin time shortened 21.91 11.18 31 189462 1558 42430284
Gingival pain 21.73 11.18 85 189408 8409 42423433
Blood viscosity decreased 21.72 11.18 9 189484 60 42431782
Oesophageal carcinoma 21.64 11.18 8 189485 9688 42422154
Splenic haematoma 21.55 11.18 12 189481 164 42431678
Cardiac ventricular thrombosis 21.45 11.18 33 189460 1789 42430053
Palpitations 21.41 11.18 331 189162 50466 42381376
Forced expiratory volume decreased 21.37 11.18 4 189489 7626 42424216
Psychomotor hyperactivity 21.35 11.18 11 189482 10947 42420895
Pneumonia fungal 21.35 11.18 7 189486 9139 42422703
Hypersensitivity 21.34 11.18 212 189281 72158 42359684
Paraesthesia 21.32 11.18 216 189277 73243 42358599
Mouth ulceration 21.32 11.18 21 189472 14942 42416900
Depressed mood 21.29 11.18 45 189448 23339 42408503
Conjunctivitis 21.06 11.18 16 189477 12923 42418919
Illness 21.05 11.18 50 189443 24880 42406962
Palmar-plantar erythrodysaesthesia syndrome 21.01 11.18 37 189456 20545 42411297
Anticoagulation drug level increased 20.92 11.18 19 189474 583 42431259
Intentional self-injury 20.90 11.18 22 189471 15180 42416662
Blood pressure decreased 20.86 11.18 370 189123 57962 42373880
Diffuse large B-cell lymphoma 20.76 11.18 8 189485 9446 42422396
Intentional dose omission 20.76 11.18 7 189486 8979 42422863
Withdrawal syndrome 20.75 11.18 21 189472 14754 42417088
Mitral valve replacement 20.57 11.18 12 189481 180 42431662
Infected skin ulcer 20.52 11.18 34 189459 1964 42429878
Labelled drug-disease interaction medication error 20.50 11.18 11 189482 139 42431703
Protein S deficiency 20.50 11.18 10 189483 102 42431740
Myocarditis 20.30 11.18 33 189460 18905 42412937
Anal abscess 20.19 11.18 5 189488 7845 42423997
Erythema 20.19 11.18 351 189142 108442 42323400
Gravitational oedema 20.13 11.18 20 189473 688 42431154
Anger 20.06 11.18 17 189476 13001 42418841
Muscle strain 20.04 11.18 55 189438 4522 42427320
Injection site erythema 19.99 11.18 37 189456 20158 42411684
Herpes zoster 19.83 11.18 97 189396 38780 42393062
Encephalitis 19.70 11.18 8 189485 9150 42422692
Thrombotic microangiopathy 19.65 11.18 22 189471 14760 42417082
Anticoagulation drug level decreased 19.63 11.18 12 189481 197 42431645
Peripheral swelling 19.61 11.18 533 188960 89737 42342105
Polyneuropathy 19.55 11.18 33 189460 18628 42413214
Anastomotic infection 19.53 11.18 10 189483 114 42431728
Prothrombin level increased 19.47 11.18 12 189481 200 42431642
Catheter removal 19.42 11.18 12 189481 201 42431641
Dermatitis atopic 19.35 11.18 16 189477 12388 42419454
Adrenal insufficiency 19.34 11.18 34 189459 18890 42412952
Therapeutic response shortened 19.34 11.18 19 189474 13535 42418307
Coagulation test abnormal 19.33 11.18 19 189474 645 42431197
Blood urea increased 19.32 11.18 227 189266 32566 42399276
Cerebellar haematoma 19.27 11.18 12 189481 204 42431638
Drug intolerance 19.22 11.18 247 189246 80177 42351665
Tremor 19.20 11.18 309 189184 96620 42335222
Gastrointestinal ulcer 19.19 11.18 32 189461 1858 42429984
Apallic syndrome 19.16 11.18 14 189479 313 42431529
Transplant evaluation 19.15 11.18 17 189476 506 42431336
Spinal cord haemorrhage 19.09 11.18 14 189479 315 42431527
Intra-abdominal haemorrhage 19.06 11.18 41 189452 2887 42428955
Hyperthyroidism 19.02 11.18 119 189374 14222 42417620
Gangrene 18.97 11.18 58 189435 5068 42426774
Haemobilia 18.93 11.18 16 189477 445 42431397
Maternal exposure during pregnancy 18.83 11.18 4 189489 6974 42424868
Large intestinal ulcer haemorrhage 18.80 11.18 10 189483 124 42431718
Pericarditis uraemic 18.80 11.18 6 189487 16 42431826
Pulmonary endarterectomy 18.69 11.18 9 189484 89 42431753
Pulmonary haemorrhage 18.66 11.18 100 189393 11297 42420545
Dry eye 18.59 11.18 25 189468 15481 42416361
Puncture site haematoma 18.57 11.18 11 189482 170 42431672
Poisoning deliberate 18.55 11.18 11 189482 10123 42421719
Hypoprothrombinaemia 18.48 11.18 16 189477 460 42431382
Cerebral infarction 18.47 11.18 216 189277 30953 42400889
Potentiating drug interaction 18.43 11.18 67 189426 6401 42425441
Anaphylactic shock 18.43 11.18 49 189444 23468 42408374
Urinary bladder haemorrhage 18.39 11.18 31 189462 1816 42430026
Hypertransaminasaemia 18.37 11.18 9 189484 9218 42422624
Influenza like illness 18.30 11.18 76 189417 31764 42400078
Brain herniation 18.25 11.18 55 189438 4768 42427074
Skin exfoliation 18.25 11.18 109 189384 41444 42390398
Ventricular hyperkinesia 18.20 11.18 12 189481 226 42431616
Chest tube insertion 18.18 11.18 9 189484 95 42431747
Pulmonary vasculitis 18.17 11.18 3 189490 6263 42425579
Neurotoxicity 17.99 11.18 50 189443 23601 42408241
Blood cholinesterase decreased 17.97 11.18 11 189482 181 42431661
Bovine tuberculosis 17.94 11.18 9 189484 98 42431744
Mental disorder 17.88 11.18 33 189460 17996 42413846
Cardiac valve disease 17.87 11.18 44 189449 3387 42428455
Eosinophilic granulomatosis with polyangiitis 17.86 11.18 8 189485 8630 42423212
Product storage error 17.84 11.18 14 189479 11126 42420716
Hepatitis B 17.80 11.18 4 189489 6707 42425135
Hepatic failure 17.78 11.18 98 189395 38002 42393840
Implantable defibrillator replacement 17.76 11.18 5 189488 7 42431835
Tracheal calcification 17.68 11.18 4 189489 0 42431842
Vascular calcification 17.67 11.18 20 189473 801 42431041
Disease recurrence 17.58 11.18 70 189423 29608 42402234
Pathogen resistance 17.58 11.18 15 189478 11435 42420407
Drug withdrawal syndrome 17.58 11.18 44 189449 21505 42410337
Rhinitis 17.55 11.18 102 189391 11875 42419967
Diarrhoea 17.55 11.18 1788 187705 459061 41972781
Haemorrhagic cholecystitis 17.50 11.18 10 189483 144 42431698
Catheter site pain 17.47 11.18 29 189464 1678 42430164
Right ventricular diastolic collapse 17.46 11.18 8 189485 70 42431772
Pulmonary haematoma 17.46 11.18 8 189485 70 42431772
Arteriovenous fistula site haemorrhage 17.40 11.18 9 189484 105 42431737
Device occlusion 17.29 11.18 79 189414 8371 42423471
Oesophageal ulcer 17.29 11.18 46 189447 3713 42428129
Periorbital haematoma 17.26 11.18 14 189479 367 42431475
Hyperglycaemia 17.26 11.18 126 189367 45733 42386109
Electrolyte imbalance 17.22 11.18 31 189462 17070 42414772
Acute respiratory distress syndrome 17.22 11.18 72 189421 30036 42401806
Epstein-Barr virus infection 17.16 11.18 11 189482 9707 42422135
Impaired work ability 17.10 11.18 102 189391 11989 42419853
Dystonia 17.04 11.18 19 189474 12771 42419071
Cognitive disorder 17 11.18 86 189407 34086 42397756
Glomerular filtration rate 16.96 11.18 9 189484 111 42431731
Xanthopsia 16.91 11.18 10 189483 154 42431688
Spinal cord haematoma 16.89 11.18 9 189484 112 42431730
Bradyarrhythmia 16.89 11.18 37 189456 2638 42429204
Splenic rupture 16.88 11.18 28 189465 1619 42430223
Gout 16.88 11.18 195 189298 27860 42403982
Osteoarthritis 16.83 11.18 54 189439 24351 42407491
Incarcerated hernia 16.80 11.18 10 189483 156 42431686
Neurological symptom 16.72 11.18 12 189481 9979 42421863
Encephalomalacia 16.59 11.18 22 189471 1039 42430803
Cardiolipin antibody positive 16.59 11.18 6 189487 26 42431816
Toxic epidermal necrolysis 16.55 11.18 62 189431 26688 42405154
Hypophagia 16.50 11.18 188 189305 26768 42405074
Protein C decreased 16.41 11.18 6 189487 27 42431815
Lichen planus 16.28 11.18 24 189469 1253 42430589
Adenovirus infection 16.27 11.18 5 189488 6804 42425038
Pancreatic haemorrhage 16.24 11.18 6 189487 28 42431814
Concomitant disease progression 16.24 11.18 35 189458 2468 42429374
Tumour haemorrhage 16.21 11.18 44 189449 3594 42428248
Cardiac ventricular disorder 16.17 11.18 12 189481 275 42431567
Feeling hot 16.16 11.18 52 189441 23430 42408412
Swelling 16.16 11.18 338 189155 54547 42377295
Radiation proctitis 16.16 11.18 10 189483 168 42431674
Right atrial enlargement 16.13 11.18 12 189481 276 42431566
Syringe issue 16.07 11.18 9 189484 8547 42423295
Klebsiella infection 16.03 11.18 16 189477 11316 42420526
Catatonia 15.99 11.18 4 189489 6235 42425607
Eye irritation 15.99 11.18 16 189477 11302 42420540
Erectile dysfunction 15.90 11.18 57 189436 24856 42406986
Respiratory depression 15.80 11.18 38 189455 18830 42413012
Exercise tolerance decreased 15.76 11.18 61 189432 6005 42425837
Medical device site haematoma 15.74 11.18 6 189487 31 42431811
Procedural site reaction 15.70 11.18 10 189483 177 42431665
Uveitis 15.65 11.18 11 189482 9247 42422595
Enteritis 15.62 11.18 15 189478 10801 42421041
Polyomavirus-associated nephropathy 15.61 11.18 3 189490 5612 42426230
Anaesthesia 15.60 11.18 7 189486 58 42431784
Proctalgia 15.58 11.18 6 189487 7087 42424755
Hypocalcaemia 15.55 11.18 75 189418 30098 42401744
Delusion 15.49 11.18 26 189467 14708 42417134
Breast haematoma 15.46 11.18 4 189489 3 42431839
Hepatic haematoma 15.46 11.18 14 189479 428 42431414
Impaired quality of life 15.42 11.18 112 189381 14065 42417777
Craniotomy 15.42 11.18 10 189483 183 42431659
Fistula 15.33 11.18 8 189485 7904 42423938
Gastrointestinal erosion 15.32 11.18 14 189479 433 42431409
Rhinovirus infection 15.31 11.18 5 189488 6543 42425299
Jugular vein distension 15.30 11.18 17 189476 667 42431175
Hepatic rupture 15.30 11.18 7 189486 61 42431781
Blood pressure systolic abnormal 15.27 11.18 3 189490 5525 42426317
Hypothyroidism 15.26 11.18 82 189411 32002 42399840
Agranulocytosis 15.25 11.18 77 189416 30535 42401307
Strangury 15.20 11.18 9 189484 139 42431703
Muscle spasms 15.20 11.18 280 189213 85764 42346078
Panic attack 15.17 11.18 16 189477 11029 42420813
Aortic valve replacement 15.16 11.18 20 189473 940 42430902
Nausea 15.02 11.18 1540 187953 395259 42036583
Blood creatinine increased 15.02 11.18 615 188878 109388 42322454
Euphoric mood 14.96 11.18 5 189488 6448 42425394
Fear 14.93 11.18 16 189477 10949 42420893
Central venous catheterisation 14.92 11.18 27 189466 1674 42430168
N-telopeptide urine increased 14.87 11.18 6 189487 37 42431805
Salivary hypersecretion 14.86 11.18 16 189477 10927 42420915
Infusion site haemorrhage 14.86 11.18 23 189470 1254 42430588
Incision site haemorrhage 14.79 11.18 15 189478 529 42431313
Orthostatic hypotension 14.77 11.18 204 189289 30366 42401476
Sinus node dysfunction 14.70 11.18 51 189442 4761 42427081
Drug dose omission by device 14.66 11.18 4 189489 5882 42425960
Incision site haematoma 14.65 11.18 8 189485 105 42431737
Heart valve operation 14.64 11.18 7 189486 68 42431774
Wound haemorrhage 14.63 11.18 32 189461 2279 42429563
Cardiac disorder 14.62 11.18 302 189191 48630 42383212
Ketoacidosis 14.58 11.18 3 189490 5349 42426493
Hypomagnesaemia 14.57 11.18 71 189422 28417 42403425
Basal cell carcinoma 14.52 11.18 52 189441 22681 42409161
Mitral valve thickening 14.47 11.18 14 189479 466 42431376
Skin fissures 14.46 11.18 13 189480 9663 42422179
Catheter site infection 14.46 11.18 38 189455 3045 42428797
Brain natriuretic peptide increased 14.38 11.18 64 189429 6706 42425136
Paracentesis 14.37 11.18 14 189479 470 42431372
Cor pulmonale 14.25 11.18 18 189475 810 42431032
Brain stem haemorrhage 14.23 11.18 20 189473 999 42430843
Pseudomonas infection 14.20 11.18 31 189462 15892 42415950
Left ventricular enlargement 14.18 11.18 18 189475 814 42431028
Endarterectomy 14.15 11.18 9 189484 159 42431683
Analgesic therapy 14.11 11.18 62 189431 6462 42425380
Accidental overdose 14.08 11.18 190 189303 28140 42403702
Protein C deficiency 14.04 11.18 4 189489 6 42431836
Product dose omission in error 14.02 11.18 10 189483 8344 42423498
Tongue haemorrhage 14.01 11.18 17 189476 734 42431108
Peptic ulcer 13.96 11.18 40 189453 3372 42428470
Increased tendency to bruise 13.95 11.18 47 189446 4323 42427519
Muscle rigidity 13.90 11.18 20 189473 12039 42419803
Ankle deformity 13.87 11.18 10 189483 219 42431623
Hepatic encephalopathy 13.86 11.18 33 189460 16409 42415433
Enterococcal infection 13.84 11.18 20 189473 12019 42419823
Vitamin K deficiency 13.81 11.18 13 189480 418 42431424
Blood pressure diastolic abnormal 13.77 11.18 5 189488 6123 42425719
Eye haemorrhage 13.74 11.18 50 189443 4780 42427062
Acute cutaneous lupus erythematosus 13.73 11.18 7 189486 79 42431763
Gastrointestinal angiodysplasia 13.72 11.18 16 189477 662 42431180
Ulnar nerve palsy 13.67 11.18 4 189489 7 42431835
Presyncope 13.64 11.18 156 189337 22231 42409611
Subdural haematoma evacuation 13.59 11.18 5 189488 23 42431819
Refusal of treatment by patient 13.58 11.18 53 189440 5238 42426604
Injection site swelling 13.58 11.18 35 189458 16938 42414904
Left ventricular failure 13.57 11.18 58 189435 5973 42425869
Gastric polyps 13.52 11.18 26 189467 1689 42430153
Rebound effect 13.52 11.18 8 189485 7371 42424471
Encephalopathy 13.51 11.18 118 189375 41215 42390627
Tuberculosis 13.46 11.18 15 189478 10084 42421758
Vitamin K decreased 13.45 11.18 6 189487 49 42431793
Aortic bruit 13.44 11.18 10 189483 230 42431612
Haemorrhagic infarction 13.39 11.18 14 189479 512 42431330
Cystitis haemorrhagic 13.35 11.18 8 189485 7321 42424521
Fungal infection 13.35 11.18 44 189449 19678 42412164
Cardiac pacemaker replacement 13.31 11.18 9 189484 177 42431665
Therapeutic response decreased 13.31 11.18 103 189390 36909 42394933
Vascular pseudoaneurysm 13.31 11.18 34 189459 2678 42429164
Procedural haemorrhage 13.30 11.18 35 189458 2806 42429036
Prothrombin level decreased 13.29 11.18 21 189472 1165 42430677
Walking distance test abnormal 13.27 11.18 9 189484 178 42431664
Cardiolipin antibody 13.26 11.18 3 189490 0 42431842
Vena cava filter removal 13.26 11.18 3 189490 0 42431842
Vascular fragility 13.26 11.18 3 189490 0 42431842
Arteriovenous graft site haemorrhage 13.26 11.18 3 189490 0 42431842
Alcohol use 13.25 11.18 35 189458 2813 42429029
Cardioactive drug level above therapeutic 13.24 11.18 6 189487 51 42431791
Night sweats 13.21 11.18 45 189448 19924 42411918
Haemorrhoids 13.20 11.18 125 189368 16972 42414870
Skin lesion 13.17 11.18 69 189424 27105 42404737
Metastases to lung 13.11 11.18 19 189474 11405 42420437
Crying 13.10 11.18 6 189487 6388 42425454
Blood potassium increased 13.08 11.18 133 189360 18403 42413439
Aspartate aminotransferase increased 13.04 11.18 253 189240 76910 42354932
Vitreous haemorrhage 13.03 11.18 34 189459 2713 42429129
Iris haemorrhage 13.01 11.18 4 189489 9 42431833
Nephrolithiasis 13.01 11.18 103 189390 36727 42395115
Aphthous ulcer 12.95 11.18 5 189488 5896 42425946
Tricuspid valve replacement 12.94 11.18 5 189488 27 42431815
Hemiparesis 12.90 11.18 126 189367 17250 42414592
Hepatic vein thrombosis 12.87 11.18 7 189486 91 42431751
Blood pressure systolic decreased 12.83 11.18 50 189443 4937 42426905
Peripheral sensory neuropathy 12.83 11.18 12 189481 8750 42423092
Procalcitonin abnormal 12.82 11.18 12 189481 383 42431459
Poisoning 12.79 11.18 29 189464 14670 42417172
Eye haematoma 12.79 11.18 8 189485 137 42431705
Heart rate irregular 12.72 11.18 118 189375 15932 42415910
Cellulitis 12.63 11.18 361 189132 61224 42370618
Antiphospholipid antibodies positive 12.59 11.18 12 189481 392 42431450
Hydrocephalus 12.57 11.18 57 189436 6021 42425821
Left atrial enlargement 12.55 11.18 19 189474 1016 42430826
Injection site pruritus 12.50 11.18 14 189479 9391 42422451
Hepatitis C 12.49 11.18 16 189477 10117 42421725
Subcapsular renal haematoma 12.46 11.18 14 189479 556 42431286
Hyperammonaemia 12.45 11.18 10 189483 7856 42423986
Ankylosing spondylitis 12.44 11.18 8 189485 7048 42424794
Arteriosclerosis coronary artery 12.41 11.18 42 189451 18635 42413207
Foetal growth restriction 12.41 11.18 4 189489 5279 42426563
Femoral nerve palsy 12.40 11.18 6 189487 60 42431782
Heartland virus infection 12.37 11.18 5 189488 31 42431811
Large intestine polyp 12.36 11.18 77 189416 9188 42422654
Thrombectomy 12.36 11.18 7 189486 99 42431743
Circulatory collapse 12.36 11.18 160 189333 23476 42408366
Endocarditis 12.32 11.18 70 189423 8082 42423760
Hypercholesterolaemia 12.32 11.18 24 189469 12825 42419017
Intracranial haematoma 12.24 11.18 14 189479 567 42431275
Coagulation factor V level increased 12.24 11.18 5 189488 32 42431810
Therapeutic response increased 12.21 11.18 10 189483 266 42431576
Ear infection 12.20 11.18 24 189469 12780 42419062
Tachycardia 12.19 11.18 349 189144 100738 42331104
Ubiquinone decreased 12.19 11.18 4 189489 12 42431830
Hypoaesthesia 12.17 11.18 234 189259 71229 42360613
Miosis 12.14 11.18 26 189467 13420 42418422
Injection site reaction 12.13 11.18 33 189460 15688 42416154
Eye pruritus 12.12 11.18 20 189473 11392 42420450
Burning feet syndrome 12.12 11.18 7 189486 103 42431739
Dysphagia 12.11 11.18 239 189254 72480 42359362
Basal ganglia haemorrhage 12.10 11.18 19 189474 1049 42430793
Eosinophilia 12.09 11.18 91 189402 32808 42399034
Transaminases increased 12.07 11.18 91 189402 32794 42399048
Post procedural haematoma 12.04 11.18 24 189469 1601 42430241
Throat tightness 12.00 11.18 15 189478 9584 42422258
Pain in extremity 11.99 11.18 800 188693 149804 42282038
Gastric antral vascular ectasia 11.98 11.18 12 189481 417 42431425
Myasthenia gravis 11.97 11.18 117 189376 16020 42415822
Paraesthesia oral 11.97 11.18 4 189489 5159 42426683
Antipsychotic drug level increased 11.95 11.18 3 189490 4663 42427179
Coagulation time abnormal 11.89 11.18 7 189486 107 42431735
Hypoalbuminaemia 11.87 11.18 33 189460 15577 42416265
Cardiac pseudoaneurysm 11.86 11.18 5 189488 35 42431807
Status epilepticus 11.80 11.18 33 189460 15545 42416297
Elbow operation 11.76 11.18 8 189485 159 42431683
Pulmonary arterial pressure increased 11.74 11.18 23 189470 1515 42430327
Libido decreased 11.73 11.18 4 189489 5094 42426748
Antiphospholipid antibodies 11.73 11.18 4 189489 14 42431828
Lipase increased 11.71 11.18 18 189475 10548 42421294
Upper airway obstruction 11.71 11.18 16 189477 778 42431064
Scrotal oedema 11.69 11.18 26 189467 1873 42429969
Post transplant lymphoproliferative disorder 11.66 11.18 14 189479 9106 42422736
Blood pressure diastolic increased 11.66 11.18 7 189486 6398 42425444
Aneurysm ruptured 11.65 11.18 14 189479 598 42431244
Sleep disorder therapy 11.64 11.18 61 189432 6833 42425009
Acute hepatic failure 11.62 11.18 38 189455 17035 42414807
Aspiration pleural cavity 11.61 11.18 17 189476 882 42430960
Infusion site warmth 11.60 11.18 9 189484 221 42431621
Metastases to bone 11.49 11.18 31 189462 14778 42417064
Spinal osteoarthritis 11.47 11.18 13 189480 8673 42423169
Skin laceration 11.46 11.18 104 189389 13954 42417888
Cardiac failure high output 11.45 11.18 6 189487 72 42431770
Oral herpes 11.44 11.18 10 189483 7534 42424308
Obsessive-compulsive disorder 11.41 11.18 8 189485 6735 42425107
Sterile pyuria 11.40 11.18 5 189488 39 42431803
Heart transplant 11.39 11.18 18 189475 999 42430843
Exposure to toxic agent 11.39 11.18 4 189489 5000 42426842
Wound decomposition 11.38 11.18 6 189487 73 42431769
Productive cough 11.37 11.18 161 189332 51406 42380436
Budd-Chiari syndrome 11.31 11.18 4 189489 16 42431826
Respiratory symptom 11.30 11.18 20 189473 11086 42420756
Oesophageal pain 11.27 11.18 18 189475 1008 42430834
Iron deficiency 11.25 11.18 86 189407 10975 42420867
Dysgeusia 11.22 11.18 214 189279 33975 42397867
Left atrial volume increased 11.20 11.18 3 189490 3 42431839
Epiphyseal disorder 11.20 11.18 3 189490 3 42431839
Mood altered 11.18 11.18 19 189474 10699 42421143

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 21596.44 10.21 8648 339876 78124 110162651
Haemorrhage 2818.35 10.21 2480 346044 104212 110136563
Drug interaction 2689.01 10.21 5272 343252 494911 109745864
International normalised ratio abnormal 2465.90 10.21 879 347645 5478 110235297
Gastric haemorrhage 2308.35 10.21 1087 347437 14828 110225947
Gastrointestinal haemorrhage 2206.58 10.21 2663 345861 162855 110077920
International normalised ratio decreased 2069.39 10.21 829 347695 7407 110233368
Anticoagulation drug level above therapeutic 1986.06 10.21 690 347834 3940 110236835
Haematoma 1550.57 10.21 1363 347161 57113 110183662
Calciphylaxis 1485.34 10.21 542 347982 3645 110237130
Subdural haematoma 1420.49 10.21 1064 347460 35390 110205385
Melaena 1265.52 10.21 1310 347214 67447 110173328
Haematuria 1185.08 10.21 1384 347140 81621 110159154
Epistaxis 1168.98 10.21 1729 346795 128643 110112132
Haemorrhage intracranial 1013.24 10.21 793 347731 28176 110212599
Haemoglobin decreased 972.70 10.21 2309 346215 246418 109994357
Pulmonary arterial hypertension 948.11 10.21 801 347723 31767 110209008
Cardiac failure congestive 918.36 10.21 1681 346843 149319 110091456
Anaemia 915.94 10.21 3778 344746 543308 109697467
Cerebral haemorrhage 901.90 10.21 1068 347456 63900 110176875
Labelled drug-drug interaction medication error 870.14 10.21 729 347795 28573 110212202
Anticoagulation drug level below therapeutic 851.47 10.21 286 348238 1448 110239327
Synovitis 801.53 10.21 12 348512 274080 109966695
Off label use 784.22 10.21 2293 346231 1497892 108742883
Drug ineffective 772.61 10.21 2355 346169 1518185 108722590
Prothrombin time prolonged 765.67 10.21 545 347979 16716 110224059
Dyspnoea 685.20 10.21 5877 342647 1100995 109139780
Pemphigus 657.62 10.21 3 348521 214567 110026208
Infusion related reaction 645.92 10.21 199 348325 380963 109859812
Fluid retention 638.94 10.21 1101 347423 93206 110147569
International normalised ratio fluctuation 620.35 10.21 288 348236 3792 110236983
Coagulopathy 615.35 10.21 701 347823 40210 110200565
Atrial fibrillation 607.14 10.21 1845 346679 227797 110012978
Cardiac failure 605.54 10.21 1620 346904 186006 110054769
Haemoptysis 566.77 10.21 895 347629 70459 110170316
Hand deformity 562.13 10.21 31 348493 218475 110022300
Rectal haemorrhage 561.31 10.21 1196 347328 118637 110122138
Pulmonary hypertension 552.65 10.21 772 347752 54448 110186327
Glossodynia 520.98 10.21 49 348475 221955 110018820
Abdominal wall haematoma 509.58 10.21 281 348243 5424 110235351
Duodenal ulcer perforation 494.81 10.21 14 348510 177686 110063089
Folliculitis 487.23 10.21 8 348516 167645 110073130
Pain in jaw 481.91 10.21 695 347829 50482 110190293
Right ventricular failure 481.82 10.21 497 348027 25457 110215318
Joint swelling 476.27 10.21 417 348107 442428 109798347
Febrile neutropenia 466.52 10.21 207 348317 316560 109924215
Pericarditis 465.48 10.21 68 348456 219046 110021729
Muscle haemorrhage 458.51 10.21 280 348244 6589 110234186
Helicobacter infection 458.08 10.21 29 348495 181848 110058927
Drug intolerance 457.79 10.21 366 348158 406146 109834629
Alopecia 457.07 10.21 293 348231 364460 109876315
Stomatitis 448.90 10.21 146 348378 270096 109970679
Psoriatic arthropathy 432.32 10.21 55 348469 196706 110044069
Hypervolaemia 425.83 10.21 644 347880 48816 110191959
Hepatic enzyme increased 415.56 10.21 248 348276 320644 109920131
Fall 414.97 10.21 3285 345239 600197 109640578
Therapeutic product effect decreased 414.69 10.21 127 348397 244189 109996586
Rheumatoid arthritis 413.34 10.21 214 348310 299399 109941376
Arthropathy 410.77 10.21 196 348328 287326 109953449
Upper gastrointestinal haemorrhage 402.83 10.21 632 347892 49464 110191311
C-reactive protein abnormal 391.23 10.21 3 348521 129692 110111083
Irritable bowel syndrome 385.90 10.21 36 348488 164179 110076596
Hypersensitivity 372.05 10.21 435 348089 403563 109837212
Treatment failure 369.26 10.21 207 348317 277027 109963748
Ecchymosis 367.84 10.21 357 348167 16981 110223794
Catheter site erythema 367.63 10.21 232 348292 5796 110234979
Muscle injury 362.02 10.21 20 348504 140787 110099988
Transfusion 358.77 10.21 422 348102 25050 110215725
Retroperitoneal haematoma 354.11 10.21 228 348296 5903 110234872
Type 2 diabetes mellitus 351.94 10.21 66 348458 177166 110063609
Wound 350.17 10.21 150 348374 234287 110006488
Arthralgia 349.62 10.21 1272 347252 778360 109462415
Dyspnoea exertional 348.20 10.21 911 347613 103149 110137626
Hypotension 347.06 10.21 2828 345696 521021 109719754
Subarachnoid haemorrhage 342.53 10.21 445 348079 29257 110211518
Fibromyalgia 332.29 10.21 67 348457 170842 110069933
Musculoskeletal stiffness 330.12 10.21 240 348284 279582 109961193
Thrombosis 325.22 10.21 913 347611 107749 110133026
Faeces discoloured 323.94 10.21 464 348060 33484 110207291
Syncope 323.12 10.21 1380 347144 201156 110039619
Contraindicated product administered 319.78 10.21 193 348331 248074 109992701
Drug hypersensitivity 317.54 10.21 592 347932 453498 109787277
Sleep disorder due to general medical condition, insomnia type 302.99 10.21 6 348518 105637 110135138
Product use in unapproved indication 296.54 10.21 602 347922 446775 109794000
Discomfort 293.62 10.21 155 348369 214552 110026223
Subdural haemorrhage 292.98 10.21 208 348316 6350 110234425
Haematemesis 289.51 10.21 601 347923 58507 110182268
Impaired healing 288.79 10.21 129 348395 196588 110044187
Bursitis 288.56 10.21 35 348489 129883 110110892
Facet joint syndrome 288.42 10.21 3 348521 96825 110143950
Haematocrit decreased 287.94 10.21 641 347883 65476 110175299
Maternal exposure during pregnancy 283.60 10.21 232 348292 254651 109986124
Systemic lupus erythematosus 282.38 10.21 232 348292 254106 109986669
Therapeutic product effect incomplete 279.90 10.21 180 348344 223625 110017150
Cerebrovascular accident 279.77 10.21 1223 347301 180061 110060714
Retroperitoneal haemorrhage 279.39 10.21 196 348328 5869 110234906
Lip dry 278.15 10.21 8 348516 100075 110140700
Device related infection 276.25 10.21 468 348056 39051 110201724
Coagulation time prolonged 275.26 10.21 149 348375 2768 110238007
Product use issue 273.77 10.21 348 348176 311347 109929428
Catheter site pain 270.92 10.21 197 348327 6249 110234526
Deep vein thrombosis 266.11 10.21 1007 347517 138880 110101895
Catheter management 264.12 10.21 158 348366 3577 110237198
Oedema peripheral 259.79 10.21 1850 346674 326810 109913965
Blister 255.40 10.21 205 348319 227171 110013604
Wheezing 254.56 10.21 257 348267 254973 109985802
Ill-defined disorder 251.26 10.21 90 348434 156763 110084012
Osteoarthritis 249.45 10.21 132 348392 182491 110058284
Urticaria 246.30 10.21 390 348134 318467 109922308
Asthma 246.25 10.21 255 348269 250036 109990739
Inflammation 243.56 10.21 154 348370 193084 110047691
Heparin-induced thrombocytopenia 240.04 10.21 234 348290 11190 110229585
Sinusitis 235.73 10.21 356 348168 296332 109944443
Swollen joint count increased 235.06 10.21 6 348518 83655 110157120
Pain 233.76 10.21 1908 346616 953047 109287728
Lower gastrointestinal haemorrhage 230.58 10.21 288 348236 18198 110222577
Joint range of motion decreased 226.16 10.21 53 348471 121779 110118996
Liver injury 218.62 10.21 100 348424 150313 110090462
Rash 216.83 10.21 1606 346918 819358 109421417
Obesity 215.04 10.21 47 348477 113304 110127471
Catheter site discharge 213.21 10.21 127 348397 2852 110237923
Neutropenia 211.06 10.21 550 347974 374070 109866705
Blood loss anaemia 210.87 10.21 272 348252 17753 110223022
Myelosuppression 210.52 10.21 25 348499 94315 110146460
Intraventricular haemorrhage 206.15 10.21 157 348367 5350 110235425
Hypoaesthesia 205.39 10.21 426 348098 313797 109926978
Catheter site pruritus 201.61 10.21 112 348412 2194 110238581
Shock haemorrhagic 200.22 10.21 330 348194 26917 110213858
Night sweats 199.57 10.21 86 348438 133897 110106878
Lower respiratory tract infection 198.66 10.21 286 348238 242820 109997955
Haemarthrosis 198.48 10.21 173 348351 7156 110233619
Intra-abdominal haematoma 195.31 10.21 127 348397 3345 110237430
Head injury 192.88 10.21 422 348102 42595 110198180
Pruritus 192.13 10.21 1062 347462 580498 109660277
Exposure during pregnancy 191.71 10.21 148 348376 167276 110073499
Mobility decreased 191.37 10.21 282 348242 237140 110003635
Skin necrosis 190.69 10.21 284 348240 21228 110219547
Sleep disorder 189.09 10.21 208 348316 198436 110042339
Catheter site haemorrhage 188.54 10.21 153 348371 5727 110235048
Hypertension 187.37 10.21 898 347626 509186 109731589
Catheter site infection 187.37 10.21 174 348350 7826 110232949
Pulmonary embolism 186.98 10.21 1237 347287 213237 110027538
Gastrointestinal disorder 186.73 10.21 296 348228 241656 109999119
Hypercholesterolaemia 184.25 10.21 32 348492 90805 110149970
Drug abuse 183.39 10.21 173 348351 177238 110063537
Paraesthesia 183.14 10.21 372 348152 276149 109964626
Central venous catheterisation 181.27 10.21 126 348398 3716 110237059
Activated partial thromboplastin time prolonged 179.52 10.21 282 348242 22086 110218689
Haematoma muscle 178.75 10.21 128 348396 3962 110236813
Injury 176.13 10.21 179 348345 177086 110063689
Thrombosis in device 175.87 10.21 141 348383 5186 110235589
Device alarm issue 174.34 10.21 104 348420 2342 110238433
Grip strength decreased 172.25 10.21 24 348500 80150 110160625
Death 171.99 10.21 3125 345399 695744 109545031
C-reactive protein increased 170.63 10.21 264 348260 217655 110023120
Infection 167.89 10.21 582 347942 361618 109879157
Blood cholesterol increased 167.74 10.21 201 348323 184584 110056191
Appendicolith 166.58 10.21 215 348309 14040 110226735
Cytokine release syndrome 163.58 10.21 16 348508 70290 110170485
Pyrexia 159.29 10.21 1939 346585 896326 109344449
General physical health deterioration 158.31 10.21 745 347779 424550 109816225
Acute kidney injury 157.21 10.21 2844 345680 632586 109608189
Palpitations 157.20 10.21 948 347576 158264 110082511
Deep vein thrombosis postoperative 156.91 10.21 7 348517 59284 110181491
Blepharospasm 153.84 10.21 4 348520 54847 110185928
Anticoagulant-related nephropathy 153.80 10.21 47 348477 164 110240611
Occult blood positive 153.63 10.21 151 348373 7294 110233481
Cardiogenic shock 152.50 10.21 462 348062 56876 110183899
Peripheral venous disease 151.43 10.21 39 348485 84078 110156697
Prescribed overdose 151.30 10.21 44 348480 87537 110153238
Post procedural haemorrhage 150.89 10.21 214 348310 15298 110225477
Haemorrhagic stroke 148.80 10.21 200 348324 13589 110227186
Intentional product use issue 148.10 10.21 353 348171 247553 109993222
Catheter placement 147.62 10.21 105 348419 3215 110237560
Depression 146.31 10.21 511 348013 316824 109923951
Atrial flutter 145.90 10.21 269 348255 23993 110216782
Injection site reaction 144.52 10.21 50 348474 89020 110151755
Autoimmune disorder 142.10 10.21 19 348505 65464 110175311
Ventricular tachycardia 141.60 10.21 412 348112 49597 110191178
Wound infection 140.37 10.21 64 348460 96401 110144374
Mucosal inflammation 139.56 10.21 64 348460 96077 110144698
Bradycardia 139.17 10.21 903 347621 154614 110086161
Sciatica 134.92 10.21 61 348463 92338 110148437
Complication associated with device 134.08 10.21 233 348291 19840 110220935
Psoriasis 132.76 10.21 147 348377 139846 110100929
Spinal epidural haematoma 132.55 10.21 77 348447 1648 110239127
Bone erosion 131.51 10.21 3 348521 46368 110194407
Blood pressure decreased 131.11 10.21 712 347812 114379 110126396
Hyperkalaemia 129.88 10.21 802 347722 134994 110105781
Live birth 129.40 10.21 30 348494 69454 110171321
Ventricular fibrillation 129.36 10.21 353 348171 40960 110199815
Cerebral mass effect 127.60 10.21 85 348439 2334 110238441
Catheter site swelling 125.83 10.21 83 348441 2241 110238534
Haemorrhage subcutaneous 124.97 10.21 118 348406 5421 110235354
Infusion site pain 124.01 10.21 208 348316 17211 110223564
Leukopenia 122.54 10.21 174 348350 148617 110092158
Cardiac pacemaker insertion 121.18 10.21 123 348401 6178 110234597
Adjustment disorder with depressed mood 120.15 10.21 4 348520 43879 110196896
Anaphylactic reaction 119.82 10.21 110 348414 114190 110126585
Intestinal haematoma 118.21 10.21 44 348480 315 110240460
Gingival bleeding 118.08 10.21 219 348305 19620 110221155
Injection site pain 118.06 10.21 239 348285 177683 110063092
Malignant neoplasm progression 117.98 10.21 232 348292 174335 110066440
COVID-19 116.06 10.21 390 348134 244670 109996105
Haematochezia 116.01 10.21 691 347833 114833 110125942
Dizziness 115.18 10.21 2947 345577 695246 109545529
Epilepsy 114.17 10.21 89 348435 100120 110140655
Red blood cell sedimentation rate increased 113.85 10.21 52 348472 78250 110162525
Haemoperitoneum 112.52 10.21 110 348414 5278 110235497
Cerebellar haemorrhage 111.02 10.21 88 348436 3183 110237592
Ascites 110.37 10.21 581 347943 92227 110148548
Presyncope 110.05 10.21 372 348152 48515 110192260
Nail disorder 109.92 10.21 24 348500 57911 110182864
Sleep disorder due to a general medical condition 108.71 10.21 17 348507 52095 110188680
Flushing 107.43 10.21 630 347894 104106 110136669
Onychomadesis 107.27 10.21 10 348514 45653 110195122
Lung transplant 106.82 10.21 106 348418 5180 110235595
Extradural haematoma 106.62 10.21 87 348437 3282 110237493
Subcutaneous haematoma 105.89 10.21 83 348441 2953 110237822
Intentional overdose 104.19 10.21 160 348364 132341 110108434
Foot deformity 103.00 10.21 15 348509 48465 110192310
Dialysis 102.58 10.21 205 348319 19414 110221361
X-ray abnormal 102.54 10.21 4 348520 38113 110202662
Device occlusion 101.08 10.21 176 348348 15009 110225766
Abdominal discomfort 101.06 10.21 776 347748 393082 109847693
Insomnia 100.93 10.21 693 347831 359897 109880878
Dry mouth 100.38 10.21 310 348214 199638 110041137
Cardiac failure chronic 99.76 10.21 166 348358 13645 110227130
Pulmonary oedema 99.09 10.21 599 347925 100060 110140715
Spontaneous haematoma 98.87 10.21 67 348457 1894 110238881
Prothrombin time ratio increased 98.68 10.21 38 348486 302 110240473
Conjunctival haemorrhage 98.60 10.21 113 348411 6520 110234255
Cardiac tamponade 98.39 10.21 148 348376 11159 110229616
Anxiety 98.17 10.21 660 347864 344418 109896357
Appendicitis 98.04 10.21 252 348272 28212 110212563
Gout 97.58 10.21 295 348229 36271 110204504
Cardiac disorder 97.29 10.21 487 348037 75793 110164982
Exostosis 95.84 10.21 15 348509 45941 110194834
Prescribed underdose 95.19 10.21 43 348481 65131 110175644
Traumatic haematoma 95.01 10.21 71 348453 2350 110238425
Coeliac disease 94.98 10.21 12 348512 43175 110197600
Cardiac failure acute 93.31 10.21 223 348301 23855 110216920
Intra-abdominal haemorrhage 93.24 10.21 99 348425 5243 110235532
Blood phosphorus increased 93.05 10.21 177 348347 16163 110224612
Cardioactive drug level increased 92.01 10.21 85 348439 3797 110236978
Oxygen saturation decreased 91.26 10.21 824 347700 156158 110084617
Hypercoagulation 91.05 10.21 79 348445 3247 110237528
Infusion site infection 89.99 10.21 67 348457 2205 110238570
Musculoskeletal pain 89.59 10.21 287 348237 182736 110058039
Internal haemorrhage 89.32 10.21 133 348391 9938 110230837
Cellulitis 88.97 10.21 691 347833 125325 110115450
Pericardial haemorrhage 88.09 10.21 95 348429 5122 110235653
Hepatic cytolysis 87.44 10.21 32 348492 55021 110185754
Coagulation test abnormal 86.74 10.21 57 348467 1529 110239246
Road traffic accident 86.06 10.21 128 348396 107270 110133505
Ear haemorrhage 85.47 10.21 67 348457 2384 110238391
Drug dependence 84.81 10.21 26 348498 49994 110190781
Muscle spasms 84.71 10.21 521 348003 277636 109963139
Onychomycosis 84.03 10.21 11 348513 38520 110202255
Catheter site inflammation 83.92 10.21 51 348473 1189 110239586
Blood creatinine increased 83.04 10.21 912 347612 181977 110058798
Potentiating drug interaction 82.84 10.21 139 348385 11504 110229271
Taste disorder 82.50 10.21 52 348472 65335 110175440
Cardiac operation 82.23 10.21 98 348426 5897 110234878
Lower limb fracture 82.00 10.21 70 348454 75278 110165497
Catheter site rash 81.44 10.21 47 348477 993 110239782
Transient ischaemic attack 81.25 10.21 408 348116 63574 110177201
Gastritis erosive 81.07 10.21 140 348384 11860 110228915
Drug ineffective for unapproved indication 80.06 10.21 125 348399 102713 110138062
Renal failure 79.45 10.21 1076 347448 225498 110015277
Pulmonary haemorrhage 79.01 10.21 166 348358 16290 110224485
Aortic stenosis 78.78 10.21 145 348379 12914 110227861
Compartment syndrome 78.42 10.21 95 348429 5815 110234960
Device leakage 78.35 10.21 163 348361 15885 110224890
Asthenia 78.32 10.21 2778 345746 686221 109554554
Neutrophil count decreased 78.07 10.21 165 348359 120776 110119999
Drug-induced liver injury 77.34 10.21 164 348360 119903 110120872
Pulmonary arterial pressure increased 77.32 10.21 88 348436 5039 110235736
Injection site erythema 76.68 10.21 111 348413 94065 110146710
Catheterisation cardiac 76.48 10.21 96 348428 6095 110234680
Swelling 76.40 10.21 722 347802 350319 109890456
International normalised ratio 75.60 10.21 24 348500 98 110240677
Vascular pseudoaneurysm 75.53 10.21 79 348445 4111 110236664
Hypocoagulable state 75.43 10.21 64 348460 2551 110238224
Steroid dependence 75.33 10.21 112 348412 8357 110232418
Lung disorder 74.43 10.21 303 348221 179744 110061031
Myocardial infarction 74.39 10.21 929 347595 191154 110049621
Burns second degree 74.21 10.21 106 348418 7627 110233148
Gastrointestinal arteriovenous malformation 73.95 10.21 43 348481 922 110239853
Oxygen consumption increased 73.19 10.21 90 348434 5595 110235180
Spinal subdural haematoma 72.66 10.21 28 348496 223 110240552
Pregnancy 72.56 10.21 35 348489 51032 110189743
Catarrh 72.54 10.21 102 348422 7233 110233542
Adrenal haemorrhage 72.53 10.21 40 348484 772 110240003
Gastric ulcer haemorrhage 72.48 10.21 121 348403 9973 110230802
Prothrombin time abnormal 72.37 10.21 47 348477 1235 110239540
Chest pain 71.71 10.21 1621 346903 374754 109866021
Choroidal haemorrhage 71.47 10.21 26 348498 173 110240602
Suicidal ideation 71.41 10.21 116 348408 93821 110146954
Atrial thrombosis 71.39 10.21 78 348446 4268 110236507
Tongue haematoma 71.39 10.21 28 348496 235 110240540
Food interaction 71.13 10.21 57 348467 2095 110238680
Pelvic haematoma 70.62 10.21 43 348481 1006 110239769
Medical device change 70.57 10.21 33 348491 442 110240333
Pulmonary alveolar haemorrhage 70.02 10.21 179 348345 19971 110220804
Haemothorax 69.87 10.21 98 348426 6933 110233842
Brain natriuretic peptide increased 69.57 10.21 126 348398 11083 110229692
Congestive hepatopathy 69.41 10.21 84 348440 5136 110235639
Antiphospholipid syndrome 69.22 10.21 60 348464 2463 110238312
Nasopharyngitis 68.99 10.21 853 347671 393508 109847267
Gait inability 68.75 10.21 211 348313 136165 110104610
Hepatitis 68.65 10.21 111 348413 89943 110150832
Pulmonary fibrosis 68.59 10.21 136 348388 101906 110138869
Cerebral haematoma 68.54 10.21 115 348409 9517 110231258
Cardiac valve replacement complication 68.47 10.21 26 348498 198 110240577
Pulmonary endarterectomy 68.09 10.21 27 348497 234 110240541
Abdominal distension 67.86 10.21 847 347677 174256 110066519
Liver function test increased 67.63 10.21 109 348415 88439 110152336
Cerebral infarction 67.55 10.21 333 348191 51505 110189270
Infusion site erythema 67.43 10.21 129 348395 11830 110228945
Therapy partial responder 67.05 10.21 17 348507 37044 110203731
Mental status changes 66.84 10.21 440 348084 75682 110165093
Haematoma evacuation 66.64 10.21 30 348494 366 110240409
Muscle spasticity 65.90 10.21 16 348508 35899 110204876
Mouth haemorrhage 65.85 10.21 137 348387 13351 110227424
Hip arthroplasty 65.58 10.21 48 348476 55765 110185010
Accidental exposure to product 65.57 10.21 38 348486 49970 110190805
Duodenal ulcer haemorrhage 65.43 10.21 102 348422 7935 110232840
Cardioversion 65.26 10.21 56 348468 2267 110238508
Device related sepsis 64.99 10.21 99 348425 7548 110233227
Immunodeficiency 64.40 10.21 21 348503 38817 110201958
Injection site pruritus 64.34 10.21 41 348483 51217 110189558
Lethargy 64.33 10.21 510 348014 93066 110147709
Suicide attempt 64.30 10.21 144 348380 103250 110137525
Loss of consciousness 64.26 10.21 921 347603 195385 110045390
Transplant evaluation 63.64 10.21 50 348474 1785 110238990
Brain herniation 63.31 10.21 106 348418 8757 110232018
Embolic stroke 63.03 10.21 105 348419 8638 110232137
Scrotal haematoma 62.69 10.21 19 348505 64 110240711
Adverse event 62.53 10.21 158 348366 108651 110132124
Colitis 62.43 10.21 144 348380 102179 110138596
Hospitalisation 62.13 10.21 705 347819 141788 110098987
Serotonin syndrome 61.90 10.21 57 348467 59096 110181679
Osteoporosis 61.34 10.21 113 348411 87039 110153736
Accidental overdose 61.27 10.21 324 348200 51510 110189265
Joint stiffness 61.15 10.21 73 348451 67170 110173605
Arrhythmia 60.99 10.21 402 348122 69173 110171602
Sedation 60.90 10.21 78 348446 69605 110171170
Venous pressure jugular increased 60.67 10.21 43 348481 1309 110239466
Intracardiac thrombus 60.58 10.21 71 348453 4197 110236578
Pulmonary thrombosis 59.88 10.21 134 348390 13729 110227046
Mediastinal haematoma 59.64 10.21 24 348500 217 110240558
Migraine 59.56 10.21 308 348216 171344 110069431
Duodenal ulcer 59.36 10.21 165 348359 19349 110221426
Renal haemorrhage 59.29 10.21 55 348469 2470 110238305
Illness 59.21 10.21 105 348419 82066 110158709
Product label confusion 58.96 10.21 3 348521 22674 110218101
Therapeutic response decreased 58.71 10.21 136 348388 96363 110144412
Diverticulum 58.23 10.21 142 348382 15384 110225391
Memory impairment 57.82 10.21 373 348151 196571 110044204
Pancytopenia 57.54 10.21 405 348119 209208 110031567
Acute myeloid leukaemia 57.47 10.21 24 348500 38086 110202689
Arteriovenous malformation 56.79 10.21 48 348476 1903 110238872
Spinal cord haematoma 56.72 10.21 25 348499 289 110240486
Heart rate increased 56.69 10.21 698 347826 143136 110097639
Blood urea increased 56.62 10.21 331 348193 54626 110186149
Knee arthroplasty 56.45 10.21 73 348451 64875 110175900
Hypopnoea 56.04 10.21 116 348408 11264 110229511
Respiratory failure 55.98 10.21 972 347552 214360 110026415
Laryngitis 55.93 10.21 32 348492 42379 110198396
Mallory-Weiss syndrome 55.91 10.21 59 348465 3102 110237673
Diverticulum intestinal haemorrhagic 55.90 10.21 72 348452 4691 110236084
Generalised tonic-clonic seizure 55.68 10.21 54 348470 54626 110186149
Eye haemorrhage 55.63 10.21 118 348406 11656 110229119
Hypophagia 55.54 10.21 319 348205 52307 110188468
Therapy change 55.34 10.21 107 348417 9890 110230885
Cardiac murmur 55.07 10.21 187 348337 24441 110216334
Prosthetic cardiac valve thrombosis 54.95 10.21 18 348506 83 110240692
Liver disorder 54.72 10.21 246 348278 141997 110098778
Weight increased 54.52 10.21 962 347562 418682 109822093
Device expulsion 54.31 10.21 15 348509 30876 110209899
Multiple sclerosis relapse 54.27 10.21 47 348477 50193 110190582
Injection site swelling 54.17 10.21 69 348455 61721 110179054
Haematotoxicity 54.15 10.21 3 348521 21079 110219696
Neoplasm progression 53.71 10.21 75 348449 64520 110176255
Gastric ulcer 53.44 10.21 258 348266 39569 110201206
Protein C decreased 53.44 10.21 17 348507 70 110240705
Drug tolerance decreased 53.08 10.21 11 348513 27529 110213246
Oedema 52.50 10.21 942 347582 209034 110031741
Catheter removal 52.49 10.21 30 348494 622 110240153
Pleural effusion 52.41 10.21 819 347705 176890 110063885
Hyphaema 51.51 10.21 36 348488 1071 110239704
Product administration error 51.32 10.21 243 348281 36974 110203801
Blood uric acid increased 51.28 10.21 167 348357 21362 110219413
Heart valve replacement 51.28 10.21 37 348487 1159 110239616
Haemorrhagic diathesis 51.25 10.21 88 348436 7420 110233355
Nasal congestion 51.17 10.21 504 348020 97778 110142997
Unevaluable event 50.58 10.21 340 348184 58887 110181888
Anticoagulation drug level increased 50.49 10.21 34 348490 951 110239824
Coagulation time shortened 50.42 10.21 25 348499 384 110240391
Orthopnoea 50.40 10.21 109 348415 10912 110229863
Heart rate irregular 50.37 10.21 228 348296 34046 110206729
Ear pain 50.32 10.21 56 348468 53170 110187605
Dry eye 50.27 10.21 61 348463 55732 110185043
Chest wall haematoma 49.57 10.21 27 348497 508 110240267
Dyspepsia 49.51 10.21 375 348149 190590 110050185
Rales 49.43 10.21 181 348343 24558 110216217
Lupus-like syndrome 49.35 10.21 34 348490 40758 110200017
Ear infection 49.07 10.21 76 348448 62656 110178119
Disability 48.96 10.21 17 348507 30206 110210569
Rheumatoid nodule 48.88 10.21 4 348520 20292 110220483
Traumatic intracranial haemorrhage 48.58 10.21 39 348485 1437 110239338
Back injury 48.05 10.21 47 348477 47352 110193423
Bradyarrhythmia 47.89 10.21 68 348456 4866 110235909
Concomitant disease progression 47.85 10.21 58 348466 3552 110237223
Parosmia 47.80 10.21 119 348405 13061 110227714
Dehydration 47.46 10.21 1185 347339 278326 109962449
Colitis ulcerative 47.09 10.21 109 348415 77254 110163521
Hydrocephalus 46.75 10.21 102 348422 10273 110230502
Psychotic disorder 46.63 10.21 55 348469 50882 110189893
Oral herpes 46.48 10.21 28 348496 36052 110204723
Abdominal pain upper 46.07 10.21 798 347726 348313 109892462
Blue toe syndrome 45.80 10.21 28 348496 660 110240115
Loss of personal independence in daily activities 45.64 10.21 281 348243 149739 110091036
Anticoagulation drug level decreased 45.46 10.21 21 348503 273 110240502
Lymphopenia 45.34 10.21 36 348488 40134 110200641
Vitamin K deficiency 45.32 10.21 31 348493 890 110239885
Therapeutic product effect increased 45.27 10.21 40 348484 1685 110239090
Sepsis 45.15 10.21 1351 347173 325995 109914780
Infected skin ulcer 45.05 10.21 59 348465 3908 110236867
Dizziness postural 44.90 10.21 124 348400 14485 110226290
Joint dislocation 44.80 10.21 26 348498 34164 110206611
Acute respiratory failure 44.72 10.21 397 348127 74863 110165912
Catheter site irritation 44.68 10.21 27 348497 623 110240152
Penile necrosis 44.33 10.21 14 348510 56 110240719
Hypovolaemic shock 44.05 10.21 123 348401 14460 110226315
Torsade de pointes 44.02 10.21 164 348360 22436 110218339
Hepatotoxicity 43.91 10.21 83 348441 63317 110177458
Subarachnoid haematoma 43.89 10.21 21 348503 297 110240478
Aortic valve replacement 43.26 10.21 38 348486 1588 110239187
Bronchopulmonary aspergillosis 43.15 10.21 20 348504 29843 110210932
Cytomegalovirus infection reactivation 43.10 10.21 4 348520 18329 110222446
Laryngeal haematoma 42.97 10.21 18 348506 182 110240593
Foetal warfarin syndrome 42.87 10.21 9 348515 0 110240775
Exercise tolerance decreased 42.76 10.21 108 348416 11959 110228816
Thalamus haemorrhage 42.71 10.21 41 348483 1923 110238852
Dystonia 42.70 10.21 14 348510 25791 110214984
Liver function test abnormal 42.67 10.21 367 348157 68583 110172192
Sedation complication 42.51 10.21 6 348518 19849 110220926
Aplastic anaemia 42.37 10.21 12 348512 24296 110216479
White blood cell count decreased 42.05 10.21 491 348033 228899 110011876
Petechiae 41.96 10.21 165 348359 23152 110217623
Atrial tachycardia 41.09 10.21 90 348434 9088 110231687
Blood potassium increased 40.79 10.21 210 348314 33039 110207736
Cytomegalovirus infection 40.66 10.21 68 348456 54376 110186399
Angioedema 40.55 10.21 166 348358 98334 110142441
Mesenteric haematoma 40.42 10.21 14 348510 79 110240696
Cardiac ablation 40.39 10.21 46 348478 2636 110238139
Dermatitis atopic 40.30 10.21 15 348509 25526 110215249
Atheroembolism 40.30 10.21 21 348503 360 110240415
Mineral supplementation 39.95 10.21 28 348496 837 110239938
Contusion 39.80 10.21 990 347534 232371 110008404
Hypoprothrombinaemia 39.60 10.21 29 348495 930 110239845
Aphthous ulcer 39.60 10.21 9 348515 21127 110219648
Dermatitis contact 39.54 10.21 115 348409 13838 110226937
Schizophrenia 39.51 10.21 10 348514 21816 110218959
Large intestinal haemorrhage 39.30 10.21 49 348475 3090 110237685
Drug monitoring procedure not performed 39.29 10.21 33 348491 1297 110239478
Pneumocystis jirovecii pneumonia 39.28 10.21 46 348478 42689 110198086
Analgesic therapy 39.15 10.21 77 348447 7207 110233568
Chronic sinusitis 39.13 10.21 15 348509 25069 110215706
Endocarditis 38.66 10.21 111 348413 13260 110227515
Chronic obstructive pulmonary disease 38.48 10.21 519 348005 108639 110132136
Arthritis 38.45 10.21 340 348184 167246 110073529
Blood urine present 38.45 10.21 165 348359 24080 110216695
Device connection issue 38.44 10.21 32 348492 1242 110239533
Completed suicide 38.42 10.21 535 347989 241846 109998929
Cardiac valve disease 38.36 10.21 71 348453 6350 110234425
Device interaction 38.18 10.21 26 348498 741 110240034
Tracheal calcification 38.10 10.21 8 348516 0 110240775
No adverse event 38.10 10.21 113 348411 73726 110167049
Condition aggravated 37.89 10.21 1911 346613 732925 109507850
Dilatation ventricular 37.85 10.21 55 348469 4020 110236755
Myxoedema coma 37.83 10.21 25 348499 677 110240098
Female genital tract fistula 37.80 10.21 4 348520 16515 110224260
Pericardial effusion 37.77 10.21 309 348215 56908 110183867
Pneumonia aspiration 37.27 10.21 406 348118 80827 110159948
Catheter site discolouration 37.24 10.21 15 348509 136 110240639
Basal cell carcinoma 37.20 10.21 53 348471 45217 110195558
Hemianopia homonymous 37.14 10.21 34 348490 1501 110239274
Lymphocyte count decreased 37.02 10.21 78 348446 57165 110183610
Prothrombin consumption time prolonged 36.77 10.21 11 348513 35 110240740
Catheter site related reaction 36.74 10.21 33 348491 1421 110239354
Therapeutic response shortened 36.67 10.21 24 348500 29559 110211216
Feeling hot 36.59 10.21 155 348369 90951 110149824
Endarterectomy 36.50 10.21 20 348504 381 110240394
Sinus node dysfunction 36.37 10.21 85 348439 8962 110231813
Breast haematoma 36.30 10.21 16 348508 185 110240590
Conjunctivitis 36.03 10.21 32 348492 33760 110207015
Walking aid user 35.91 10.21 17 348507 25058 110215717
Haemorrhoidal haemorrhage 35.82 10.21 79 348445 8014 110232761
Embolism 35.82 10.21 123 348401 16166 110224609
Device infusion issue 35.69 10.21 46 348478 2999 110237776
Infusion site haemorrhage 35.56 10.21 57 348467 4541 110236234
Periorbital haematoma 35.53 10.21 28 348496 1004 110239771
Skin exfoliation 35.28 10.21 149 348375 87502 110153273
Cerebellar haematoma 35.20 10.21 23 348501 611 110240164
Rash maculo-papular 35.19 10.21 118 348406 74104 110166671
Hip fracture 35.10 10.21 210 348314 34941 110205834
Iron deficiency anaemia 35.09 10.21 194 348330 31365 110209410
Anovulatory cycle 34.65 10.21 14 348510 128 110240647
Gravitational oedema 34.60 10.21 36 348488 1862 110238913
Renal haematoma 34.56 10.21 27 348497 956 110239819
Food allergy 34.49 10.21 10 348514 19938 110220837
Cardiomegaly 34.37 10.21 182 348342 28948 110211827
Drug therapy 34.37 10.21 73 348451 7218 110233557
Subdural haematoma evacuation 34.32 10.21 12 348512 70 110240705
Thrombocytopenia 34.28 10.21 837 347687 348048 109892727
Infusion site reaction 34.21 10.21 7 348517 17675 110223100
Hypoxia 34.14 10.21 586 347938 128929 110111846
Obstructive airways disorder 34.13 10.21 58 348466 46091 110194684
Walking distance test abnormal 34.11 10.21 24 348500 722 110240053
Protein S deficiency 33.82 10.21 14 348510 137 110240638
Sciatic nerve palsy 33.76 10.21 12 348512 74 110240701
Procedural haemorrhage 33.67 10.21 61 348463 5366 110235409
Intentional self-injury 33.64 10.21 41 348483 37388 110203387
Febrile bone marrow aplasia 33.61 10.21 7 348517 17458 110223317
Haemophagocytic lymphohistiocytosis 33.51 10.21 30 348494 31529 110209246
Purpura 33.45 10.21 159 348365 24229 110216546
Left ventricular failure 33.37 10.21 95 348429 11294 110229481
Catheter culture positive 33.21 10.21 16 348508 230 110240545
Poisoning deliberate 33.13 10.21 21 348503 26310 110214465
Neuroleptic malignant syndrome 33.12 10.21 35 348489 34024 110206751
Mitral valve replacement 33.03 10.21 22 348502 604 110240171
Colonic haematoma 32.97 10.21 12 348512 80 110240695
Ovarian haemorrhage 32.89 10.21 18 348506 342 110240433
Vascular calcification 32.87 10.21 28 348496 1122 110239653
Immune effector cell-associated neurotoxicity syndrome 32.77 10.21 4 348520 14778 110225997
Small intestinal haemorrhage 32.68 10.21 55 348469 4563 110236212
Medical device site thrombosis 32.55 10.21 13 348511 115 110240660
Cor pulmonale 32.29 10.21 38 348486 2256 110238519
Proctitis 32.13 10.21 7 348517 16920 110223855
Blood pressure fluctuation 32.13 10.21 124 348400 74700 110166075
Pharyngeal haematoma 32.06 10.21 14 348510 158 110240617
Sopor 31.93 10.21 211 348313 36335 110204440
Delirium 31.84 10.21 272 348252 134753 110106022
Atrial septal defect repair 31.78 10.21 20 348504 497 110240278
Blood pressure systolic decreased 31.78 10.21 104 348420 13337 110227438
Adverse reaction 31.58 10.21 28 348496 29566 110211209
Spinal cord haemorrhage 31.20 10.21 21 348503 587 110240188
Infusion site warmth 31.20 10.21 33 348491 1740 110239035
Emergency care 30.97 10.21 30 348494 1423 110239352
Feeling abnormal 30.91 10.21 767 347757 179944 110060831
Palmar-plantar erythrodysaesthesia syndrome 30.86 10.21 51 348473 40974 110199801
Renal impairment 30.81 10.21 795 347729 187650 110053125
Haemodialysis 30.77 10.21 124 348400 17595 110223180
Nasal polyps 30.71 10.21 3 348521 13197 110227578
Pancreatitis 30.68 10.21 171 348353 93362 110147413
Seizure 30.66 10.21 501 348023 220684 110020091
Chest tube insertion 30.56 10.21 13 348511 137 110240638
Cytomegalovirus viraemia 30.54 10.21 9 348515 17755 110223020
Posterior reversible encephalopathy syndrome 30.53 10.21 37 348487 33824 110206951
Aggression 30.27 10.21 91 348433 59119 110181656
Catheter site vesicles 30.26 10.21 18 348506 403 110240372
Cardiac flutter 29.91 10.21 60 348464 5697 110235078
Incision site haemorrhage 29.90 10.21 26 348498 1072 110239703
Cardiac arrest 29.86 10.21 822 347702 195931 110044844
Cardiac pacemaker replacement 29.85 10.21 19 348505 482 110240293
Vaginal haemorrhage 29.82 10.21 157 348367 24917 110215858
Oral candidiasis 29.78 10.21 60 348464 44700 110196075
Graft versus host disease 29.75 10.21 11 348513 18795 110221980
Hypertransaminasaemia 29.63 10.21 20 348504 24235 110216540
Femoral nerve palsy 29.29 10.21 11 348513 81 110240694
Vaginal discharge 29.14 10.21 10 348514 17898 110222877
Arteriovenous fistula site haemorrhage 29.09 10.21 17 348507 368 110240407
Disturbance in attention 29.09 10.21 99 348425 61896 110178879
Dry skin 29.04 10.21 209 348315 107444 110133331
Urinary bladder haemorrhage 29.04 10.21 40 348484 2782 110237993
Multiple organ dysfunction syndrome 29.03 10.21 654 347870 151056 110089719
Nephropathy 29.01 10.21 101 348423 13366 110227409
Ischaemic stroke 28.96 10.21 226 348298 41037 110199738
Infusion site cellulitis 28.94 10.21 18 348506 438 110240337
Tumour haemorrhage 28.86 10.21 56 348468 5189 110235586
Amnesia 28.75 10.21 204 348320 105204 110135571
Drug resistance 28.56 10.21 87 348437 56287 110184488
Cardiac ventricular thrombosis 28.54 10.21 42 348482 3105 110237670
Wrong technique in product usage process 28.48 10.21 160 348364 87188 110153587
Blood pressure increased 28.43 10.21 609 347915 257764 109983011
Mouth ulceration 28.36 10.21 69 348455 48069 110192706
Multiple-drug resistance 28.34 10.21 4 348520 13231 110227544
Angioplasty 28.33 10.21 33 348491 1938 110238837
Infective pulmonary exacerbation of cystic fibrosis 28.26 10.21 6 348518 14765 110226010
Paracentesis 28.15 10.21 28 348496 1372 110239403
Central venous catheter removal 28.13 10.21 19 348505 534 110240241
Device difficult to use 28.10 10.21 12 348512 18793 110221982
Gingival pain 28.03 10.21 111 348413 15625 110225150
Extrasystoles 27.98 10.21 73 348451 8245 110232530
Anaphylactic shock 27.97 10.21 77 348447 51469 110189306
BK virus infection 27.97 10.21 4 348520 13102 110227673
Gastric antral vascular ectasia 27.96 10.21 26 348498 1171 110239604
Blood viscosity decreased 27.82 10.21 10 348514 64 110240711
Mitral valve incompetence 27.66 10.21 190 348334 33139 110207636
Acute generalised exanthematous pustulosis 27.64 10.21 17 348507 21647 110219128
Sinus tachycardia 27.63 10.21 62 348462 44431 110196344
Aspergillus infection 27.62 10.21 24 348500 25592 110215183
Cognitive disorder 27.62 10.21 162 348362 87349 110153426
Prothrombin level abnormal 27.61 10.21 13 348511 177 110240598
Iris haemorrhage 27.58 10.21 7 348517 9 110240766
Drug dose omission by device 27.56 10.21 6 348518 14510 110226265
Skin fissures 27.50 10.21 22 348502 24436 110216339
Haemorrhagic arteriovenous malformation 27.25 10.21 19 348505 563 110240212
Hyperphosphataemia 27.15 10.21 113 348411 16268 110224507
Restlessness 26.97 10.21 89 348435 56170 110184605
Procedural pain 26.95 10.21 44 348480 35521 110205254
Hyperthyroidism 26.82 10.21 171 348353 29090 110211685
Thrombectomy 26.75 10.21 16 348508 362 110240413
Circulatory collapse 26.69 10.21 229 348295 42764 110198011
Refusal of treatment by patient 26.66 10.21 78 348446 9416 110231359
Dizziness exertional 26.63 10.21 21 348503 754 110240021
Diabetic ketoacidosis 26.62 10.21 58 348466 42000 110198775
Sleep disorder therapy 26.62 10.21 67 348457 7404 110233371
Haemorrhagic cerebral infarction 26.61 10.21 28 348496 1467 110239308
Extrapyramidal disorder 26.61 10.21 31 348493 28836 110211939
Wound haemorrhage 26.58 10.21 51 348473 4687 110236088
Hepatic haematoma 26.58 10.21 23 348501 942 110239833
Aspiration pleural cavity 26.51 10.21 30 348494 1707 110239068
Ventricular hyperkinesia 26.46 10.21 15 348509 306 110240469
Pancreatitis acute 26.45 10.21 99 348425 60175 110180600
Platelet distribution width increased 26.40 10.21 12 348512 150 110240625
Heart transplant 26.36 10.21 29 348495 1599 110239176
Calcium deficiency 26.32 10.21 25 348499 1157 110239618
Implant site haematoma 26.31 10.21 13 348511 198 110240577
Haemorrhagic ascites 26.20 10.21 15 348509 312 110240463
Haemorrhagic infarction 26.14 10.21 22 348502 867 110239908
Paraesthesia oral 26.13 10.21 41 348483 33630 110207145
Agitation 26.09 10.21 229 348295 112822 110127953
Therapy non-responder 26.08 10.21 344 348180 156963 110083812
Product quality issue 26.08 10.21 140 348384 77159 110163616
Rhinitis 26.01 10.21 140 348384 22405 110218370
Lymphadenopathy 26.01 10.21 108 348416 63727 110177048
Catheter site warmth 25.95 10.21 15 348509 318 110240457
Vascular device infection 25.89 10.21 112 348412 16400 110224375
Apallic syndrome 25.79 10.21 24 348500 1082 110239693
Gangrene 25.75 10.21 111 348413 16230 110224545
Prothrombin level increased 25.71 10.21 18 348506 537 110240238
Diffuse large B-cell lymphoma 25.65 10.21 9 348515 15889 110224886
Coronary artery bypass 25.65 10.21 58 348466 5984 110234791
Breast necrosis 25.60 10.21 11 348513 119 110240656
Rash erythematous 25.55 10.21 152 348372 81680 110159095
Heart valve operation 25.52 10.21 13 348511 212 110240563
Pneumonia 25.48 10.21 3145 345379 873569 109367206
Product dose omission in error 25.39 10.21 22 348502 23490 110217285
Intentional dose omission 25.29 10.21 16 348508 20064 110220711
Prothrombin time shortened 25.24 10.21 43 348481 3603 110237172
Device breakage 25.24 10.21 98 348426 13671 110227104
Neck pain 25.17 10.21 257 348267 122873 110117902
Aortic valve incompetence 25.10 10.21 84 348440 10897 110229878
Splenic rupture 25.09 10.21 36 348488 2601 110238174
Post procedural haematoma 25.07 10.21 36 348488 2603 110238172
Heart sounds abnormal 25.04 10.21 27 348497 1455 110239320
Haemorrhagic ovarian cyst 25.03 10.21 19 348505 644 110240131
Finger deformity 25.02 10.21 41 348483 33051 110207724
Personality disorder 25.00 10.21 5 348519 12832 110227943
Ankylosing spondylitis 24.92 10.21 9 348515 15603 110225172
Renal disorder 24.91 10.21 252 348272 49227 110191548
Immune reconstitution inflammatory syndrome 24.82 10.21 10 348514 16216 110224559
Jugular vein distension 24.82 10.21 28 348496 1588 110239187
Blood pressure systolic abnormal 24.77 10.21 25 348499 24825 110215950
Drug use disorder 24.76 10.21 13 348511 18061 110222714
Bone marrow failure 24.75 10.21 96 348428 57752 110183023
Blood blister 24.74 10.21 44 348480 3815 110236960
Hallucination, auditory 24.71 10.21 28 348496 26369 110214406
Neuropathy peripheral 24.53 10.21 407 348117 178870 110061905
Mitral valve disease 24.51 10.21 41 348483 3384 110237391
Mitral valve stenosis 24.50 10.21 26 348498 1376 110239399
Iron deficiency 24.29 10.21 119 348405 18357 110222418
Glomerular filtration rate 24.28 10.21 12 348512 183 110240592
Pulmonary haematoma 24.23 10.21 11 348513 137 110240638
Blood potassium decreased 24.15 10.21 269 348255 53845 110186930
Tongue haemorrhage 24.05 10.21 24 348500 1181 110239594
Catheter site dermatitis 23.97 10.21 10 348514 100 110240675
Hypogammaglobulinaemia 23.93 10.21 17 348507 20059 110220716
Myocarditis 23.90 10.21 36 348488 30019 110210756
Colon cancer 23.87 10.21 109 348415 16334 110224441
Exposure via skin contact 23.84 10.21 6 348518 13141 110227634
Uveitis 23.82 10.21 20 348504 21690 110219085
Osteopenia 23.71 10.21 21 348503 22188 110218587
Oliguria 23.70 10.21 119 348405 18538 110222237
Respiratory disorder 23.68 10.21 130 348394 71252 110169523
Hepatocellular injury 23.67 10.21 81 348443 50561 110190214
Brain stem haemorrhage 23.66 10.21 29 348495 1797 110238978
Protein S decreased 23.48 10.21 11 348513 148 110240627
Factor V inhibition 23.37 10.21 15 348509 386 110240389
Post procedural complication 23.34 10.21 154 348370 26504 110214271
Upper respiratory tract infection 23.33 10.21 283 348241 131045 110109730
Large intestine polyp 23.30 10.21 102 348422 15015 110225760
Intracranial haematoma 23.27 10.21 22 348502 1012 110239763
Intraocular haematoma 23.23 10.21 7 348517 23 110240752
Renal vascular thrombosis 23.21 10.21 10 348514 109 110240666
Panniculitis 23.20 10.21 10 348514 15572 110225203
Pustular psoriasis 23.19 10.21 7 348517 13598 110227177
Haemobilia 23.09 10.21 18 348506 635 110240140
Oral mucosa haematoma 22.97 10.21 8 348516 46 110240729
COVID-19 pneumonia 22.87 10.21 52 348472 37091 110203684
Vascular pseudoaneurysm ruptured 22.84 10.21 17 348507 559 110240216
Arteriovenous graft site haemorrhage 22.73 10.21 6 348518 10 110240765
Blood culture negative 22.72 10.21 13 348511 270 110240505
Nephrogenic systemic fibrosis 22.57 10.21 52 348472 5431 110235344
Ubiquinone decreased 22.57 10.21 7 348517 26 110240749
Tumour lysis syndrome 22.51 10.21 39 348485 30762 110210013
Oxygen therapy 22.44 10.21 44 348480 4109 110236666
Vitamin K decreased 22.40 10.21 9 348515 81 110240694
Pericarditis uraemic 22.36 10.21 6 348518 11 110240764
Stress 22.35 10.21 461 348063 104887 110135888
Visual impairment 22.27 10.21 294 348230 134134 110106641
Disease recurrence 22.26 10.21 107 348417 60677 110180098
Neurotoxicity 22.20 10.21 64 348460 42143 110198632
Epstein-Barr virus infection 22.16 10.21 16 348508 18722 110222053
Venous thrombosis 22.11 10.21 68 348456 8437 110232338
Lacrimal haemorrhage 21.97 10.21 7 348517 29 110240746
Oesophageal ulcer 21.95 10.21 65 348459 7899 110232876
Bronchiectasis 21.93 10.21 193 348331 36300 110204475
N-terminal prohormone brain natriuretic peptide increased 21.92 10.21 55 348469 6066 110234709
End stage renal disease 21.90 10.21 129 348395 21344 110219431
Cerebral artery embolism 21.83 10.21 30 348494 2082 110238693
Myasthenia gravis 21.79 10.21 129 348395 21382 110219393
Xanthopsia 21.79 10.21 14 348510 361 110240414
Hernia repair 21.79 10.21 33 348491 2503 110238272
Protein C deficiency 21.78 10.21 7 348517 30 110240745
Injection site rash 21.75 10.21 25 348499 23394 110217381
Gastrointestinal angiodysplasia 21.71 10.21 23 348501 1215 110239560
Scleroderma 21.69 10.21 56 348468 6285 110234490
Cholestasis 21.68 10.21 117 348407 64401 110176374
Eschar 21.63 10.21 25 348499 1456 110239319
Right ventricular enlargement 21.61 10.21 21 348503 1000 110239775
Hypertriglyceridaemia 21.57 10.21 12 348512 16142 110224633
Product storage error 21.50 10.21 22 348502 21706 110219069
Angiodysplasia 21.34 10.21 25 348499 1477 110239298
Gastrointestinal erosion 21.33 10.21 22 348502 1126 110239649
Peripheral ischaemia 21.33 10.21 80 348444 10978 110229797
Gastritis 21.32 10.21 261 348263 53438 110187337
Anastomotic infection 21.25 10.21 10 348514 136 110240639
Thrombotic microangiopathy 21.22 10.21 37 348487 29112 110211663
Intentional product misuse 21.17 10.21 293 348231 132611 110108164
Fat embolism 21.17 10.21 16 348508 539 110240236
Drug eruption 21.11 10.21 92 348432 53567 110187208
Cataract 21.11 10.21 155 348369 79330 110161445
Herpes zoster 21.02 10.21 229 348295 108150 110132625
Systemic infection 20.95 10.21 3 348521 9816 110230959
Paradoxical drug reaction 20.94 10.21 3 348521 9814 110230961
Thyroid haemorrhage 20.90 10.21 9 348515 98 110240677
Gait disturbance 20.82 10.21 693 347831 277515 109963260
Normal newborn 20.74 10.21 23 348501 21873 110218902
Atrioventricular block complete 20.71 10.21 121 348403 19961 110220814
Prothrombin level decreased 20.68 10.21 27 348497 1783 110238992
Product complaint 20.57 10.21 93 348431 13879 110226896
Left ventricular enlargement 20.50 10.21 19 348505 852 110239923
Muscular weakness 20.50 10.21 611 347913 247857 109992918
Hyperbilirubinaemia 20.50 10.21 41 348483 30630 110210145
Catheter site dryness 20.44 10.21 7 348517 38 110240737
Inappropriate schedule of product administration 20.41 10.21 487 348037 203150 110037625
Injection site warmth 20.41 10.21 15 348509 17390 110223385
Tricuspid valve incompetence 20.35 10.21 137 348387 23736 110217039
Intestinal haemorrhage 20.32 10.21 60 348464 7281 110233494
Hepatic steatosis 20.28 10.21 82 348442 48749 110192026
Livedo reticularis 20.27 10.21 50 348474 5456 110235319
Breast cancer female 20.22 10.21 7 348517 12461 110228314
Large intestinal ulcer haemorrhage 20.21 10.21 13 348511 336 110240439
Substance abuse 20.21 10.21 7 348517 12456 110228319
Right ventricular dysfunction 20.17 10.21 37 348487 3286 110237489
Medical device site haematoma 20.14 10.21 7 348517 40 110240735
Catheter site mass 20.11 10.21 8 348516 70 110240705
Medication error 20.08 10.21 454 348070 104912 110135863
Injection site urticaria 19.97 10.21 15 348509 17200 110223575
Tuberculosis 19.97 10.21 16 348508 17758 110223017
Thoracic haemorrhage 19.97 10.21 12 348512 274 110240501
Hyponatraemic syndrome 19.96 10.21 18 348506 779 110239996
Right atrial enlargement 19.95 10.21 15 348509 501 110240274
Haemorrhagic cholecystitis 19.86 10.21 10 348514 159 110240616
Ovarian rupture 19.85 10.21 7 348517 42 110240733
Nephrosclerosis 19.83 10.21 28 348496 1993 110238782
Urinary bladder rupture 19.80 10.21 10 348514 160 110240615
Acne 19.78 10.21 48 348476 33472 110207303
Abdominal cavity drainage 19.78 10.21 19 348505 892 110239883
Encephalomalacia 19.70 10.21 24 348500 1478 110239297
Adrenal insufficiency 19.68 10.21 68 348456 42322 110198453
Hypochromasia 19.67 10.21 17 348507 695 110240080
Labelled drug-disease interaction medication error 19.64 10.21 13 348511 353 110240422
Psychomotor hyperactivity 19.54 10.21 21 348503 20256 110220519
Haemorrhage urinary tract 19.50 10.21 34 348490 2902 110237873
Device adhesion issue 19.50 10.21 3 348521 9307 110231468
Hemiparesis 19.48 10.21 218 348306 43685 110197090
Hypovolaemia 19.46 10.21 126 348398 21548 110219227
Affect lability 19.45 10.21 18 348506 18619 110222156
Chordae tendinae rupture 19.35 10.21 8 348516 78 110240697
Dyspnoea at rest 19.21 10.21 64 348460 8282 110232493
Multiple injuries 19.18 10.21 38 348486 3576 110237199
Pulmonary calcification 19.18 10.21 15 348509 532 110240243
Infusion site irritation 19.15 10.21 21 348503 1154 110239621
Crying 19.14 10.21 32 348492 25596 110215179
Muscle strain 19.14 10.21 78 348446 11124 110229651
Tendonitis 19.09 10.21 33 348491 26050 110214725
Haemorrhoids 19.08 10.21 184 348340 35488 110205287
Spondylitis 19.03 10.21 6 348518 11332 110229443
Anticoagulant therapy 19.02 10.21 48 348476 5313 110235462
Stent placement 18.96 10.21 58 348466 7176 110233599
Hypokalaemia 18.93 10.21 434 348090 182014 110058761
Tongue necrosis 18.89 10.21 9 348515 126 110240649
Subcapsular renal haematoma 18.84 10.21 19 348505 947 110239828
Emotional distress 18.82 10.21 75 348449 44772 110196003
Lip haemorrhage 18.71 10.21 23 348501 1429 110239346
Neutrophil count increased 18.63 10.21 52 348472 34600 110206175
Chronic kidney disease 18.61 10.21 341 348183 75950 110164825
Left atrial enlargement 18.51 10.21 25 348499 1706 110239069
Akathisia 18.49 10.21 16 348508 17097 110223678
Electrocardiogram QT prolonged 18.49 10.21 462 348062 108498 110132277
Metastases to central nervous system 18.46 10.21 27 348497 22790 110217985
Depressed mood 18.44 10.21 114 348410 60695 110180080
Low cardiac output syndrome 18.43 10.21 20 348504 1086 110239689
Implantable defibrillator replacement 18.35 10.21 5 348519 10 110240765
Procalcitonin abnormal 18.33 10.21 13 348511 396 110240379
Catheter site nodule 18.25 10.21 7 348517 55 110240720
Gastrointestinal ulcer 18.20 10.21 41 348483 4219 110236556
Hyperhidrosis 18.20 10.21 450 348074 186848 110053927
General symptom 18.19 10.21 3 348521 8843 110231932
Arterial rupture 18.17 10.21 18 348506 878 110239897
Vaginal haematoma 18.16 10.21 9 348515 138 110240637
Investigation 18.16 10.21 29 348495 2303 110238472
Urine output decreased 18.12 10.21 116 348408 19760 110221015
Carpal tunnel syndrome 18.06 10.21 27 348497 22583 110218192
Transplant rejection 18.05 10.21 31 348493 24536 110216239
Skin discolouration 18.03 10.21 235 348289 48811 110191964
Rash vesicular 18.01 10.21 12 348512 14640 110226135
Aortic bruit 18.00 10.21 11 348513 259 110240516
Medical device site haemorrhage 18.00 10.21 10 348514 196 110240579
Polyneuropathy 17.99 10.21 47 348477 31965 110208810
Exposure to toxic agent 17.98 10.21 9 348515 12849 110227926
Coagulation factor decreased 17.97 10.21 12 348512 331 110240444
Ovarian cyst ruptured 17.93 10.21 21 348503 1240 110239535
Cardiac output decreased 17.89 10.21 27 348497 2042 110238733
Increased tendency to bruise 17.86 10.21 79 348445 11679 110229096
Puncture site haematoma 17.86 10.21 11 348513 263 110240512
Application site irritation 17.78 10.21 26 348498 1911 110238864
Cardioactive drug level decreased 17.77 10.21 10 348514 201 110240574
Hallucinations, mixed 17.76 10.21 3 348521 8690 110232085
Motor dysfunction 17.75 10.21 31 348493 24375 110216400
Upper airway obstruction 17.73 10.21 25 348499 1777 110238998
Application site pruritus 17.73 10.21 40 348484 4120 110236655
Right ventricular diastolic collapse 17.67 10.21 8 348516 99 110240676
Vena cava thrombosis 17.66 10.21 36 348488 3458 110237317
Craniotomy 17.65 10.21 15 348509 599 110240176
Bradypnoea 17.64 10.21 3 348521 8646 110232129
Post transplant lymphoproliferative disorder 17.61 10.21 14 348510 15599 110225176
Spinal cord compression 17.47 10.21 58 348466 7494 110233281
Polyp 17.46 10.21 70 348454 9910 110230865
Ulnar nerve palsy 17.45 10.21 5 348519 13 110240762
Proctalgia 17.40 10.21 10 348514 13212 110227563
Mitral valve repair 17.32 10.21 12 348512 352 110240423
Arteriovenous fistula operation 17.32 10.21 12 348512 352 110240423
Antacid therapy 17.30 10.21 47 348477 5437 110235338
Pulmonary arterial pressure abnormal 17.24 10.21 18 348506 935 110239840
Bullous haemorrhagic dermatosis 17.23 10.21 12 348512 355 110240420
Renal infarct 17.18 10.21 35 348489 3360 110237415
Implantable defibrillator insertion 17.11 10.21 20 348504 1179 110239596
Blood viscosity increased 17.08 10.21 12 348512 360 110240415
Catheter site erosion 17.05 10.21 7 348517 67 110240708
Irritability 17.02 10.21 85 348439 47724 110193051
Spinal fusion surgery 16.95 10.21 4 348520 9152 110231623
Cardioactive drug level below therapeutic 16.93 10.21 5 348519 15 110240760
Gastrointestinal toxicity 16.84 10.21 7 348517 11141 110229634
Blood pressure diastolic abnormal 16.84 10.21 35 348489 25780 110214995
Pneumonitis 16.79 10.21 157 348367 76374 110164401
Infusion site oedema 16.79 10.21 22 348502 1458 110239317
Nodule 16.79 10.21 50 348474 32581 110208194
Balloon atrial septostomy 16.73 10.21 8 348516 113 110240662
Device related thrombosis 16.71 10.21 35 348489 3427 110237348
Treatment noncompliance 16.68 10.21 323 348201 72667 110168108
Haematoma infection 16.59 10.21 23 348501 1609 110239166
Mood swings 16.57 10.21 29 348495 22783 110217992
Respiratory tract infection 16.55 10.21 145 348379 71472 110169303
Blood culture positive 16.54 10.21 64 348460 8912 110231863
Status epilepticus 16.51 10.21 48 348476 31523 110209252
Heavy menstrual bleeding 16.49 10.21 98 348426 16267 110224508
Uterine haemorrhage 16.49 10.21 35 348489 3459 110237316
Mediastinal haemorrhage 16.44 10.21 7 348517 74 110240701
Peripheral sensory neuropathy 16.38 10.21 17 348507 16663 110224112
Behaviour disorder 16.38 10.21 5 348519 9642 110231133
N-telopeptide urine increased 16.36 10.21 6 348518 41 110240734
Carotid artery thrombosis 16.35 10.21 5 348519 9633 110231142
Metastases to lymph nodes 16.31 10.21 14 348510 15018 110225757
Anticoagulation drug level abnormal 16.29 10.21 11 348513 309 110240466
Aphasia 16.29 10.21 269 348255 58728 110182047
Coma scale normal 16.29 10.21 4 348520 4 110240771
Peptic ulcer 16.29 10.21 57 348467 7562 110233213
Hepatic vein thrombosis 16.26 10.21 11 348513 310 110240465
Cardioactive drug level above therapeutic 16.24 10.21 10 348514 239 110240536
Device dislocation 16.21 10.21 162 348362 31542 110209233
Product preparation error 16.17 10.21 7 348517 10872 110229903
Candida infection 16.16 10.21 87 348437 47922 110192853
Agranulocytosis 16.13 10.21 121 348403 61639 110179136
Drug reaction with eosinophilia and systemic symptoms 16.11 10.21 173 348351 81922 110158853
Dysgeusia 16.10 10.21 310 348214 69675 110171100
Gastrointestinal angiectasia 16.04 10.21 12 348512 398 110240377
Incision site haematoma 16.03 10.21 9 348515 180 110240595
Hypercalcaemia 16.02 10.21 84 348440 46573 110194202
Aneurysm 15.97 10.21 40 348484 4406 110236369
Sickle cell anaemia 15.97 10.21 16 348508 791 110239984
Multiple sclerosis 15.80 10.21 36 348488 25662 110215113
Cardiac failure high output 15.78 10.21 13 348511 497 110240278
Splenic haematoma 15.78 10.21 11 348513 326 110240449
Prostate cancer 15.76 10.21 63 348461 37578 110203197
Stress cardiomyopathy 15.64 10.21 16 348508 15790 110224985
Device physical property issue 15.64 10.21 36 348488 3758 110237017
Skin burning sensation 15.62 10.21 28 348496 21797 110218978
Cytopenia 15.60 10.21 46 348478 30070 110210705
Alcohol poisoning 15.56 10.21 63 348461 8957 110231818
Nocturnal dyspnoea 15.55 10.21 24 348500 1851 110238924
Intra-abdominal fluid collection 15.51 10.21 36 348488 3778 110236997
Insurance issue 15.50 10.21 7 348517 10605 110230170
Encephalopathy 15.43 10.21 172 348352 80883 110159892
Peripheral embolism 15.43 10.21 25 348499 2010 110238765
Aortic aneurysm 15.39 10.21 67 348457 9837 110230938
Cerebellar infarction 15.39 10.21 38 348486 4149 110236626
Fatigue 15.36 10.21 3496 345028 1212462 109028313
Metastases to lung 15.27 10.21 31 348493 23032 110217743
Bedridden 15.24 10.21 83 348441 13342 110227433
Skin laceration 15.16 10.21 168 348356 33585 110207190
Influenza like illness 15.14 10.21 192 348332 88220 110152555
Anal fistula 15.11 10.21 4 348520 8469 110232306
Liver abscess 15.10 10.21 3 348521 7736 110233039
Hepatic infarction 15.07 10.21 17 348507 964 110239811
Hepatic rupture 15.05 10.21 8 348516 143 110240632
Drug specific antibody present 15.01 10.21 4 348520 8430 110232345
Hormone-dependent prostate cancer 15.00 10.21 9 348515 205 110240570
Coordination abnormal 14.99 10.21 36 348488 25192 110215583
Headache 14.96 10.21 3073 345451 879304 109361471
Chronic respiratory failure 14.96 10.21 36 348488 3867 110236908
Alkalosis hypokalaemic 14.94 10.21 5 348519 25 110240750
Adenovirus infection 14.92 10.21 8 348516 10986 110229789
Bundle branch block left 14.85 10.21 80 348444 12808 110227967
Pseudomonal sepsis 14.81 10.21 5 348519 9041 110231734
Localised oedema 14.80 10.21 63 348461 9160 110231615
Neutrophilia 14.79 10.21 7 348517 10322 110230453
Incarcerated hernia 14.77 10.21 12 348512 450 110240325
Erythema 14.77 10.21 759 347765 290688 109950087
Blood pressure immeasurable 14.74 10.21 27 348497 2396 110238379
Transplant dysfunction 14.72 10.21 4 348520 8324 110232451
Alcohol use 14.72 10.21 37 348487 4085 110236690
Retching 14.70 10.21 122 348402 22560 110218215
Throat tightness 14.70 10.21 55 348469 33434 110207341
Post thrombotic syndrome 14.68 10.21 14 348510 651 110240124
Venous haemorrhage 14.67 10.21 11 348513 366 110240409
Radiation proctitis 14.65 10.21 9 348515 214 110240561
Aortic aneurysm rupture 14.64 10.21 20 348504 1380 110239395
Pancreatic haemorrhage 14.63 10.21 7 348517 99 110240676
Forced expiratory volume decreased 14.63 10.21 12 348512 13164 110227611
Purple glove syndrome 14.62 10.21 10 348514 287 110240488
Scrotal oedema 14.62 10.21 22 348502 1659 110239116
Disease complication 14.61 10.21 46 348478 5781 110234994
Blood pressure diastolic increased 14.50 10.21 23 348501 18784 110221991
Unresponsive to stimuli 14.48 10.21 282 348242 63508 110177267
Herpes simplex 14.45 10.21 17 348507 15747 110225028
Metastases to nervous system 14.35 10.21 10 348514 296 110240479
Application site odour 14.32 10.21 5 348519 29 110240746
Rehabilitation therapy 14.32 10.21 25 348499 2136 110238639
Catheter site oedema 14.30 10.21 8 348516 159 110240616
Congenital tracheomalacia 14.29 10.21 3 348521 0 110240775
Odynophagia 14.27 10.21 14 348510 14087 110226688
Infusion site abscess 14.26 10.21 11 348513 382 110240393
Inhibitory drug interaction 14.24 10.21 41 348483 4906 110235869
Gastric polyps 14.21 10.21 44 348480 5479 110235296
Somnolence 14.20 10.21 1105 347419 296344 109944431
Eosinophilic granulomatosis with polyangiitis 14.18 10.21 8 348516 10678 110230097
Hiatus hernia strangulated 14.18 10.21 10 348514 302 110240473
Gestational diabetes 14.14 10.21 3 348521 7386 110233389
Withdrawal syndrome 14.12 10.21 51 348473 31329 110209446
Bovine tuberculosis 14.12 10.21 8 348516 163 110240612
Demyelination 14.12 10.21 6 348518 9423 110231352
Metastases to bone 14.11 10.21 51 348473 31321 110209454
Toxicity to various agents 14.10 10.21 1313 347211 479242 109761533
Antiphospholipid antibodies positive 14.05 10.21 16 348508 917 110239858
Heartland virus infection 14.04 10.21 5 348519 31 110240744
Injection site discharge 13.99 10.21 20 348504 1440 110239335
Budd-Chiari syndrome 13.97 10.21 7 348517 110 110240665
Eosinophil cationic protein increased 13.96 10.21 6 348518 65 110240710
Catheter site urticaria 13.91 10.21 5 348519 32 110240743
Right ventricular systolic pressure increased 13.89 10.21 17 348507 1052 110239723
Intervertebral disc protrusion 13.85 10.21 43 348481 27655 110213120
Pulmonary congestion 13.85 10.21 154 348370 30812 110209963
Haemorrhagic transformation stroke 13.85 10.21 30 348494 3007 110237768
Ischaemic hepatitis 13.84 10.21 39 348485 4609 110236166
Colonoscopy 13.83 10.21 25 348499 2195 110238580
Maternal exposure before pregnancy 13.80 10.21 3 348521 7262 110233513
Paraplegia 13.79 10.21 47 348477 6153 110234622
Arteriovenous fistula 13.73 10.21 20 348504 1465 110239310
Vomiting 13.73 10.21 2595 345929 908080 109332695
Parkinsonism 13.71 10.21 31 348493 22156 110218619
Strangury 13.68 10.21 9 348515 242 110240533
Adverse drug reaction 13.67 10.21 242 348282 105317 110135458
Cervical cord compression 13.65 10.21 12 348512 502 110240273
Cardiotoxicity 13.64 10.21 20 348504 16861 110223914
Eye pruritus 13.63 10.21 55 348469 32720 110208055
Coagulation factor deficiency 13.62 10.21 10 348514 322 110240453
Pulseless electrical activity 13.59 10.21 95 348429 16662 110224113
Acquired oesophageal web 13.59 10.21 10 348514 323 110240452
Nodal rhythm 13.58 10.21 32 348492 3391 110237384
Blood urine 13.58 10.21 16 348508 951 110239824
Rebound effect 13.54 10.21 16 348508 14790 110225985
Bacterial infection 13.50 10.21 212 348312 45824 110194951
Abnormal loss of weight 13.44 10.21 66 348458 10191 110230584
Exophthalmos 13.41 10.21 25 348499 2248 110238527
Concomitant disease aggravated 13.41 10.21 93 348431 16271 110224504
Aortic dissection 13.35 10.21 40 348484 4893 110235882
Arterial haemorrhage 13.35 10.21 34 348490 3785 110236990
Arrhythmia supraventricular 13.32 10.21 26 348498 2420 110238355
Pelvic haemorrhage 13.30 10.21 8 348516 183 110240592
Atrioventricular block 13.30 10.21 95 348429 16782 110223993
Drug effective for unapproved indication 13.29 10.21 15 348509 14152 110226623
Oral disorder 13.24 10.21 11 348513 11992 110228783
Stent-graft endoleak 13.18 10.21 5 348519 38 110240737
Orthostatic hypotension 13.11 10.21 287 348237 65962 110174813
Creatinine renal clearance decreased 13.06 10.21 31 348493 21784 110218991
Progressive multifocal leukoencephalopathy 13.01 10.21 38 348486 24918 110215857
Coagulation time abnormal 13.00 10.21 8 348516 191 110240584
Body temperature increased 12.99 10.21 110 348414 54603 110186172
Infusion site pruritus 12.98 10.21 40 348484 4968 110235807
Acute myocardial infarction 12.98 10.21 351 348173 83426 110157349
Mitral valve thickening 12.98 10.21 14 348510 755 110240020
Pulse absent 12.95 10.21 70 348454 11222 110229553
Heart and lung transplant 12.92 10.21 8 348516 193 110240582
Dyspnoea paroxysmal nocturnal 12.91 10.21 26 348498 2476 110238299
Heart disease congenital 12.87 10.21 13 348511 649 110240126
Valvuloplasty cardiac 12.87 10.21 4 348520 15 110240760
Echocardiogram abnormal 12.87 10.21 27 348497 2647 110238128
Intestinal infarction 12.85 10.21 19 348505 1411 110239364
Prostatic haemorrhage 12.81 10.21 8 348516 196 110240579
Wrong technique in device usage process 12.81 10.21 3 348521 6898 110233877
Radiculopathy 12.79 10.21 26 348498 19310 110221465
Macular degeneration 12.79 10.21 31 348493 21628 110219147
Affective disorder 12.78 10.21 10 348514 11231 110229544
Abortion spontaneous 12.75 10.21 60 348464 34222 110206553
Anuria 12.75 10.21 125 348399 24216 110216559
Gastrointestinal polyp haemorrhage 12.74 10.21 14 348510 771 110240004
Basal ganglia haemorrhage 12.72 10.21 22 348502 1866 110238909
Thrombotic stroke 12.70 10.21 14 348510 774 110240001
Atrial septal defect 12.70 10.21 24 348500 2181 110238594
Complication of device insertion 12.64 10.21 6 348518 8832 110231943
Coagulation factor V level increased 12.64 10.21 5 348519 43 110240732
Nasal oedema 12.64 10.21 3 348521 6836 110233939
Diuretic therapy 12.64 10.21 8 348516 201 110240574
Vessel puncture site haemorrhage 12.64 10.21 8 348516 201 110240574
Urinary tract infection 12.58 10.21 1193 347331 325089 109915686
Factor VIII deficiency 12.52 10.21 7 348517 139 110240636
Delusion 12.51 10.21 36 348488 23719 110217056
Thyroiditis acute 12.43 10.21 8 348516 207 110240568
Blood cholinesterase decreased 12.42 10.21 11 348513 465 110240310
Extremity necrosis 12.42 10.21 33 348491 3769 110237006
Renal embolism 12.39 10.21 8 348516 208 110240567
Product substitution issue 12.36 10.21 119 348405 22942 110217833
Upper respiratory tract inflammation 12.36 10.21 36 348488 4335 110236440
Pathogen resistance 12.36 10.21 23 348501 17649 110223126
Brain contusion 12.34 10.21 20 348504 1608 110239167
Klebsiella infection 12.33 10.21 28 348496 19981 110220794
Rhabdomyolysis 12.30 10.21 480 348044 119921 110120854
Bladder necrosis 12.29 10.21 4 348520 18 110240757
Spontaneous haemorrhage 12.25 10.21 17 348507 1191 110239584
Acquired Von Willebrand's disease 12.22 10.21 3 348521 3 110240772
Blood sodium decreased 12.21 10.21 179 348345 38140 110202635
Leg amputation 12.18 10.21 35 348489 4183 110236592
Hyponatraemia 12.17 10.21 819 347705 216834 110023941
Herpes virus infection 12.15 10.21 6 348518 8632 110232143
Dermatitis allergic 12.13 10.21 32 348492 21692 110219083
Dental pulp disorder 12.12 10.21 4 348520 19 110240756
Pharyngeal swelling 12.11 10.21 12 348512 12020 110228755
Mydriasis 12.10 10.21 33 348491 22124 110218651
Drain placement 12.10 10.21 8 348516 217 110240558
Vascular graft 12.08 10.21 23 348501 2102 110238673
Vitreous haemorrhage 12.07 10.21 37 348487 4583 110236192
Heart rate abnormal 12.05 10.21 50 348474 7188 110233587
Iliac artery occlusion 12.01 10.21 10 348514 388 110240387
Microcytic anaemia 12.01 10.21 45 348479 6173 110234602
Dysentery 12.01 10.21 18 348506 1353 110239422
Anaesthesia 12.00 10.21 12 348512 592 110240183
Oropharyngeal discomfort 11.98 10.21 9 348515 10318 110230457
Synovial cyst 11.97 10.21 11 348513 11419 110229356
Parathyroid gland operation 11.95 10.21 4 348520 20 110240755
Prothrombin time ratio abnormal 11.95 10.21 4 348520 20 110240755
Human herpesvirus 6 infection 11.94 10.21 3 348521 6578 110234197
Abnormal behaviour 11.93 10.21 73 348451 38966 110201809
Neutropenic sepsis 11.92 10.21 53 348471 30693 110210082
Beta 2 microglobulin urine increased 11.88 10.21 7 348517 154 110240621
SARS-CoV-2 test positive 11.88 10.21 22 348502 16913 110223862
Colorectal cancer 11.84 10.21 7 348517 9107 110231668
Spinal osteoarthritis 11.83 10.21 29 348495 20154 110220621
Traumatic haemorrhage 11.79 10.21 21 348503 1823 110238952
Terminal state 11.78 10.21 42 348482 5625 110235150
Injection site pustule 11.72 10.21 6 348518 99 110240676
Inadequate diet 11.71 10.21 9 348515 311 110240464
Immune-mediated enterocolitis 11.66 10.21 9 348515 10176 110230599
Immunosuppression 11.65 10.21 24 348500 17735 110223040
Joint microhaemorrhage 11.65 10.21 5 348519 54 110240721
Decreased immune responsiveness 11.63 10.21 8 348516 9598 110231177
Right-to-left cardiac shunt 11.58 10.21 9 348515 316 110240459
Cyanosis 11.57 10.21 144 348380 29597 110211178
Brain natriuretic peptide 11.56 10.21 5 348519 55 110240720
Cytomegalovirus chorioretinitis 11.56 10.21 4 348520 7124 110233651
Autoimmune thyroiditis 11.55 10.21 3 348521 6431 110234344
Dyskinesia 11.52 10.21 105 348419 51341 110189434
Aneurysm ruptured 11.49 10.21 16 348508 1124 110239651
Tricuspid valve repair 11.49 10.21 4 348520 23 110240752
Tricuspid valve replacement 11.49 10.21 4 348520 23 110240752
Vascular insufficiency 11.48 10.21 11 348513 515 110240260
Rash pruritic 11.41 10.21 229 348295 97840 110142935
Coronary artery aneurysm 11.41 10.21 7 348517 166 110240609
Mucormycosis 11.41 10.21 10 348514 10618 110230157
Cough 11.36 10.21 1640 346884 460001 109780774
Acalculia 11.34 10.21 4 348520 24 110240751
Disease progression 11.34 10.21 641 347883 243393 109997382
Cardiac aneurysm 11.32 10.21 20 348504 1725 110239050
Lip injury 11.32 10.21 18 348506 1424 110239351
Plasma cell myeloma 11.32 10.21 269 348255 62667 110178108
Anal abscess 11.27 10.21 12 348512 11626 110229149
Biopsy liver 11.22 10.21 12 348512 641 110240134
Ventricular arrhythmia 11.21 10.21 62 348462 10025 110230750
Drug withdrawal syndrome 11.20 10.21 72 348452 37982 110202793
Burning feet syndrome 11.19 10.21 8 348516 247 110240528
Infusion site swelling 11.17 10.21 61 348463 9816 110230959
Skin reaction 11.17 10.21 32 348492 21112 110219663
Lupus endocarditis 11.10 10.21 8 348516 250 110240525
Refusal of treatment by relative 11.08 10.21 13 348511 769 110240006
Procalcitonin decreased 11.06 10.21 6 348518 112 110240663
Tardive dyskinesia 11.05 10.21 16 348508 13563 110227212
Conjunctivitis allergic 11.05 10.21 4 348520 6927 110233848
Postpartum venous thrombosis 11.01 10.21 3 348521 6 110240769
Model for end stage liver disease score abnormal 11.01 10.21 3 348521 6 110240769
Factor II mutation 11.01 10.21 3 348521 6 110240769
Cerebellar embolism 11.01 10.21 3 348521 6 110240769
Acquired cardiac septal defect 11.01 10.21 3 348521 6 110240769
Blood electrolytes abnormal 10.99 10.21 22 348502 2086 110238689
Eye infection 10.96 10.21 18 348506 14500 110226275
Cardiolipin antibody positive 10.91 10.21 7 348517 180 110240595
Colon operation 10.91 10.21 11 348513 548 110240227
Haemorrhagic hepatic cyst 10.89 10.21 5 348519 64 110240711
Procedural site reaction 10.87 10.21 10 348514 444 110240331
Muscle rigidity 10.85 10.21 39 348485 23992 110216783
Procalcitonin 10.82 10.21 4 348520 28 110240747
Oesophageal compression 10.82 10.21 4 348520 28 110240747
Dieulafoy's vascular malformation 10.82 10.21 4 348520 28 110240747
Pulmonary hypertensive crisis 10.82 10.21 10 348514 447 110240328
Lower respiratory tract inflammation 10.81 10.21 7 348517 183 110240592
Frontotemporal dementia 10.77 10.21 12 348512 671 110240104
Haemorrhagic disorder 10.77 10.21 20 348504 1793 110238982
Coronary arterial stent insertion 10.76 10.21 42 348482 5873 110234902
Basal ganglia haematoma 10.76 10.21 5 348519 66 110240709
Hepatorenal failure 10.71 10.21 17 348507 1343 110239432
Nasal discharge discolouration 10.67 10.21 28 348496 3173 110237602
Cardiac fibrillation 10.63 10.21 15 348509 1067 110239708
Transcatheter aortic valve implantation 10.62 10.21 5 348519 68 110240707
Anger 10.61 10.21 28 348496 18979 110221796
Biopsy liver abnormal 10.60 10.21 10 348514 459 110240316
Breast cancer stage I 10.59 10.21 5 348519 7382 110233393
Infusion site pustule 10.59 10.21 4 348520 30 110240745
Coagulation factor increased 10.56 10.21 5 348519 69 110240706
Hernia obstructive 10.56 10.21 6 348518 123 110240652
Tracheostomy 10.56 10.21 18 348506 1509 110239266
Gastrointestinal endoscopic therapy 10.37 10.21 5 348519 72 110240703
Cushingoid 10.35 10.21 13 348511 11699 110229076
Breast haemorrhage 10.33 10.21 7 348517 198 110240577
Peripheral artery thrombosis 10.30 10.21 32 348492 3992 110236783
Retinal haemorrhage 10.29 10.21 58 348466 9443 110231332
Photophobia 10.25 10.21 44 348480 25727 110215048
Ketoacidosis 10.23 10.21 10 348514 10077 110230698
Hernia hiatus repair 10.22 10.21 6 348518 131 110240644
Intracranial mass 10.22 10.21 23 348501 2365 110238410
Poisoning 10.22 10.21 52 348472 29053 110211722

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AA03 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Vitamin K antagonists
FDA EPC N0000175476 Vitamin K Antagonist
MeSH PA D000925 Anticoagulants
MeSH PA D006401 Hematologic Agents
MeSH PA D010575 Pesticides
MeSH PA D012378 Rodenticides
FDA MoA N0000175964 Vitamin K Inhibitors
CHEBI has role CHEBI:33288 rodenticide
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:50390 EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:55347 vitamin K antagonist
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:233423 antifibrotic agent
CHEBI has role CHEBI:64951 anti-HBV agent

Related Drugs by ATC class:

B01AA Vitamin K antagonists 9 drugs
acenocoumarolclorindionedicoumaroldiphenadioneethyl biscoumacetatefluindionephenindionephenprocoumontioclomarol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cerebral embolism indication 75543006 DOID:4372
Deep venous thrombosis indication 128053003
Pulmonary thromboembolism indication 233935004
Thromboembolic disorder indication 371039008
Thrombosis indication 439127006
Prevention of deep vein thrombosis indication 439993001
Thromboembolism due to Prosthetic Heart Valves indication
Myocardial Reinfarction Prevention indication
Prevention of Thromboembolism with Chronic Atrial Fibrillation indication
Deep Vein Thrombosis with Pulmonary Embolism indication
Pulmonary Thromboembolism Prevention indication
Thrombophilia off-label use 234467004 DOID:2452
Heart Failure with Paroxysmal Atrial Fibrillation off-label use
Nutritional disorder contraindication 2492009 DOID:374
Pericarditis contraindication 3238004 DOID:1787
Necrosis contraindication 6574001
Alcoholism contraindication 7200002
Obstruction of bile duct contraindication 30144000
Vasculitis contraindication 31996006 DOID:865
Hyperthyroidism contraindication 34486009 DOID:7998
Gangrene contraindication 36024000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Secondary uterine inertia contraindication 43715006
Tropical sprue contraindication 47384003 DOID:10607
Nephrotic syndrome contraindication 52254009 DOID:1184
Vitamin K deficiency contraindication 52675005 DOID:11249
Threatened abortion contraindication 54048003 DOID:9667
Hyperlipidemia contraindication 55822004 DOID:1168
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Fatty stool contraindication 66187002
Psychotic disorder contraindication 69322001
Heparin-induced thrombocytopenia contraindication 73397007
Gastrointestinal hemorrhage contraindication 74474003
Protein C deficiency disease contraindication 76407009 DOID:3756
Respiratory tract hemorrhage contraindication 95431003
Disorder of connective tissue contraindication 105969002 DOID:65
Polycythemia vera contraindication 109992005
Procedure on central nervous system contraindication 118679007
Intracranial aneurysm contraindication 128609009 DOID:10941
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Eclampsia in pregnancy contraindication 198992004
Local anesthetic intrathecal block contraindication 231249005
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Lumbar puncture contraindication 277762005
Pregnancy, function contraindication 289908002
Bacterial endocarditis contraindication 301183007
Dissection of aorta contraindication 308546005
Primary malignant neoplasm contraindication 372087000
Surgical procedure on eye proper contraindication 373353005
Pericardial effusion contraindication 373945007 DOID:118
Fever contraindication 386661006
Surgical procedure contraindication 387713003
Severe diarrhea contraindication 409587002
Traumatic injury contraindication 417746004
Genitourinary tract hemorrhage contraindication 417941003
Poor metabolizer due to cytochrome p450 CYP2C9 variant contraindication 424451001
Hypertensive urgency contraindication 443482000
Internal Hemorrhage contraindication
Indwelling Vascular Catheter contraindication
Cholesterol Embolism contraindication
Severe Diabetes Mellitus contraindication
Bleeding Risk Associated with Vitamin-K-Epoxide Reductase (Warfarin-Sensitive) Gene contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.96 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin K epoxide reductase complex subunit 1 Enzyme INHIBITOR IC50 7 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 3.98 WOMBAT-PK
Cytochrome P450 2C9 Enzyme Ki 4.87 WOMBAT-PK
Proprotein convertase subtilisin/kexin type 7 Enzyme IC50 4.61 CHEMBL
Vitamin K epoxide reductase complex subunit 1-like protein 1 Enzyme Ki 4.28 SCIENTIFIC LITERATURE

External reference:

IDSource
4019972 VUID
N0000148057 NUI
D00564 KEGG_DRUG
129-06-6 SECONDARY_CAS_RN
4018548 VANDF
4019972 VANDF
C0043031 UMLSCUI
CHEBI:10033 CHEBI
CHEMBL1464 ChEMBL_ID
CHEMBL1200879 ChEMBL_ID
DB00682 DRUGBANK_ID
CHEMBL1200772 ChEMBL_ID
D014859 MESH_DESCRIPTOR_UI
54678486 PUBCHEM_CID
6853 IUPHAR_LIGAND_ID
341 INN_ID
2610-86-8 SECONDARY_CAS_RN
5Q7ZVV76EI UNII
11289 RXNORM
1258 MMSL
5693 MMSL
d00022 MMSL
002084 NDDF
002085 NDDF
004065 NDDF
372756006 SNOMEDCT_US
41509001 SNOMEDCT_US
48603004 SNOMEDCT_US
63167009 SNOMEDCT_US
5Q7ZVV76EI INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1712 TABLET 1 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1713 TABLET 2 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1714 TABLET 2.50 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1715 TABLET 3 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1716 TABLET 4 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1718 TABLET 6 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1720 TABLET 10 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1721 TABLET 5 mg ORAL ANDA 29 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-1723 TABLET 7.50 mg ORAL ANDA 29 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1211 TABLET 1 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1212 TABLET 2 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1213 TABLET 2.50 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1214 TABLET 3 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1215 TABLET 4 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1216 TABLET 5 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1217 TABLET 6 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1218 TABLET 7.50 mg ORAL ANDA 30 sections
Jantoven HUMAN PRESCRIPTION DRUG LABEL 1 0832-1219 TABLET 10 mg ORAL ANDA 30 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16590-340 TABLET 2.50 mg ORAL ANDA 31 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16590-341 TABLET 5 mg ORAL ANDA 31 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 17856-4034 TABLET 7.50 mg ORAL ANDA 32 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-672 TABLET 1 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-673 TABLET 2 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-674 TABLET 2.50 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-675 TABLET 3 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-677 TABLET 5 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-801 TABLET 10 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-939 TABLET 10 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-940 TABLET 10 mg ORAL ANDA 24 sections
Warfarin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-355 TABLET 1 mg ORAL ANDA 31 sections