dihydrotachysterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| Vitamin D analogues/derivatives | 2841 | 67-96-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.04 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A11CC02 | ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin D and analogues |
| CHEBI has role | CHEBI:50646 | antiosteoporotic |
| MeSH PA | D050071 | Bone Density Conservation Agents |
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D014815 | Vitamins |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypophosphatemia | indication | 4996001 | |
| Hypocalcemia | indication | 5291005 | |
| Tetany | indication | 10629009 | |
| Hypoparathyroidism | indication | 36976004 | DOID:11199 |
| Rickets | indication | 41345002 | DOID:10609 |
| Renal osteodystrophy | off-label use | 16726004 | DOID:13068 |
| Hyperphosphatemia | contraindication | 20165001 | DOID:0050459 |
| Hypervitaminosis D | contraindication | 27712000 | DOID:9971 |
| Sarcoidosis | contraindication | 31541009 | DOID:11335 |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Kidney stone | contraindication | 95570007 | |
| Arteriosclerosis obliterans | contraindication | 361133006 | DOID:5160 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin D3 receptor | Nuclear hormone receptor | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4018234 | VUID |
| N0000146565 | NUI |
| D00299 | KEGG_DRUG |
| 4018234 | VANDF |
| 4021907 | VANDF |
| C0012319 | UMLSCUI |
| CHEBI:4591 | CHEBI |
| CHEMBL2356023 | ChEMBL_ID |
| D004097 | MESH_DESCRIPTOR_UI |
| DB01070 | DRUGBANK_ID |
| 5311071 | PUBCHEM_CID |
| 1610 | INN_ID |
| R5LM3H112R | UNII |
| 3429 | RXNORM |
| 4601 | MMSL |
| d03125 | MMSL |
| 001015 | NDDF |
| 126235007 | SNOMEDCT_US |
| 20237006 | SNOMEDCT_US |
Pharmaceutical products:
None