Stem definition | Drug id | CAS RN |
---|---|---|
phenylazosalicylic acid derivatives antibacterial | 284 | 80573-04-2 |
Dose | Unit | Route |
---|---|---|
6.75 | g | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 269.86 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
July 18, 2000 | FDA | SALIX PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Colitis ulcerative | 83.07 | 31.75 | 25 | 872 | 17707 | 46667458 |
Effusion | 42.82 | 31.75 | 9 | 888 | 1482 | 46683683 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Colitis ulcerative | 57.07 | 31.10 | 18 | 577 | 14416 | 29937467 |
Source | Code | Description |
---|---|---|
ATC | A07EC04 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Aminosalicylic acid and similar agents |
FDA CS | M0000971 | Aminosalicylic Acids |
FDA EPC | N0000175781 | Aminosalicylate |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drugs |
CHEBI has role | CHEBI:49201 | anti-ulcer agents |
CHEBI has role | CHEBI:55324 | gastrointestinal agents |
CHEBI has role | CHEBI:50266 | prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ulcerative colitis | indication | 64766004 | DOID:8577 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Pyloric obstruction | contraindication | 244815007 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.28 | acidic |
pKa2 | 4.08 | acidic |
pKa3 | 11.45 | acidic |
pKa4 | 12.18 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
Arachidonate 5-lipoxygenase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
ID | Source |
---|---|
P80AL8J7ZP | UNII |
4021231 | VUID |
N0000148675 | NUI |
D02715 | KEGG_DRUG |
150399-21-6 | SECONDARY_CAS_RN |
4021231 | VANDF |
4021232 | VANDF |
C0052940 | UMLSCUI |
CHEBI:267413 | CHEBI |
BLQ | PDB_CHEM_ID |
CHEMBL1201346 | ChEMBL_ID |
CHEMBL1200760 | ChEMBL_ID |
DB01014 | DRUGBANK_ID |
54585 | PUBCHEM_CID |
5221 | INN_ID |
C038637 | MESH_SUPPLEMENTAL_RECORD_UI |
11569 | IUPHAR_LIGAND_ID |
153718 | RXNORM |
130137 | MMSL |
15641 | MMSL |
d04700 | MMSL |
007156 | NDDF |
007157 | NDDF |
391811002 | SNOMEDCT_US |
420306005 | SNOMEDCT_US |
420557005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0079 | CAPSULE | 750 mg | ORAL | ANDA | 24 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-157 | CAPSULE | 750 mg | ORAL | ANDA | 24 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-102 | CAPSULE | 750 mg | ORAL | ANDA | 24 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-102 | CAPSULE | 750 mg | ORAL | ANDA | 24 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6137 | CAPSULE | 750 mg | ORAL | ANDA | 25 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60429-952 | CAPSULE | 750 mg | ORAL | ANDA | 24 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-2575 | CAPSULE | 750 mg | ORAL | ANDA | 25 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8301 | CAPSULE | 750 mg | ORAL | ANDA | 23 sections |
Colazal | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65649-101 | CAPSULE | 750 mg | ORAL | NDA authorized generic | 21 sections |
Balsalazide Disodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72789-149 | CAPSULE | 750 mg | ORAL | ANDA | 24 sections |