viloxazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2820 46817-91-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • viloxazine hydrochloride
  • viloxazine
  • emovit
  • viloxazin
  • viloxazine HCl
  • ICI 58,834
  • ICI 58834
A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.
  • Molecular weight: 237.30
  • Formula: C13H19NO3
  • CLOGP: 1.76
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 39.72
  • ALOGS: -2.28
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 85 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.73 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AX09 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cataplexy and narcolepsy indication 193042000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 6.81 CHEMBL KEGG DRUG
Sodium-dependent dopamine transporter Transporter Kd 6.81 CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 4.76 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 4.32 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 4.78 CHEMBL
Transporter Transporter Ki 6.77 CHEMBL

External reference:

IDSource
C0543469 UMLSCUI
D02572 KEGG_DRUG
5I5Y2789ZF UNII
3489 INN_ID
349857003 SNOMEDCT_US
420070007 SNOMEDCT_US
4025281 VANDF
11196 RXNORM
004063 NDDF
5666 PUBCHEM_CID
CHEBI:94405 CHEBI
CHEMBL306700 ChEMBL_ID
CHEMBL251072 ChEMBL_ID
35604-67-2 SECONDARY_CAS_RN
DB09185 DRUGBANK_ID
D014745 MESH_DESCRIPTOR_UI
CHEMBL2106483 ChEMBL_ID

Pharmaceutical products:

None