verapamil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, verapamil derivatives 2815 52-53-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • verapamil
  • RS-Verapamil
  • (+/-)-Verapamil
  • verapamil hydrochloride
  • verapamil HCl
A calcium channel blocker that is a class IV anti-arrhythmia agent.
  • Molecular weight: 454.61
  • Formula: C27H38N2O4
  • CLOGP: 4.27
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 63.95
  • ALOGS: -5.06
  • ROTB: 13
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O
0.24 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.75 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 22 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 18 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 12, 1981 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 871.84 11.58 672 32573 145001 63310776
Bradycardia 536.28 11.58 382 32863 72845 63382932
Toxicity to various agents 316.72 11.58 507 32738 246743 63209034
Cardiogenic shock 289.30 11.58 155 33090 17777 63438000
Hypotension 281.64 11.58 508 32737 272096 63183681
Atrioventricular block complete 250.57 11.58 110 33135 8141 63447636
Drug interaction 245.47 11.58 434 32811 228697 63227080
BRASH syndrome 189.76 11.58 45 33200 424 63455353
Atrioventricular block 178.80 11.58 85 33160 7562 63448215
Metabolic acidosis 177.83 11.58 164 33081 44905 63410872
Anuria 119.14 11.58 77 33168 12474 63443303
Overdose 117.82 11.58 214 33031 114864 63340913
Neovascularisation 112.04 11.58 36 33209 1109 63454668
Electrocardiogram QRS complex prolonged 106.16 11.58 55 33190 5883 63449894
Intentional overdose 105.61 11.58 160 33085 73992 63381785
Sinus bradycardia 101.92 11.58 74 33171 14477 63441300
Atrioventricular block first degree 95.71 11.58 55 33190 7218 63448559
Acute respiratory distress syndrome 95.44 11.58 87 33158 23447 63432330
Drug ineffective for unapproved indication 90.33 11.58 100 33145 33963 63421814
Electrocardiogram QT prolonged 82.70 11.58 127 33118 59403 63396374
Synovitis 81.22 11.58 4 33241 186914 63268863
Shock 80.37 11.58 79 33166 23384 63432393
Nodal rhythm 79.21 11.58 31 33214 1712 63454065
Joint swelling 78.09 11.58 37 33208 327629 63128148
Systemic lupus erythematosus 78.07 11.58 9 33236 208909 63246868
Glossodynia 77.17 11.58 4 33241 178872 63276905
Paradoxical drug reaction 75.79 11.58 39 33206 4113 63451664
Cardiac arrest 63.62 11.58 146 33099 92399 63363378
Labelled drug-drug interaction medication error 63.25 11.58 54 33191 13345 63442432
Arthropathy 61.54 11.58 23 33222 234769 63221008
Cryopyrin associated periodic syndrome 59.72 11.58 17 33228 343 63455434
Infusion related reaction 59.58 11.58 27 33218 245494 63210283
Pericarditis 56.56 11.58 3 33242 131576 63324201
Therapeutic product effect decreased 55.76 11.58 16 33229 193171 63262606
Wound 50.01 11.58 12 33233 163251 63292526
Contraindicated product administered 48.20 11.58 27 33218 217621 63238156
Nodal arrhythmia 46.98 11.58 19 33226 1144 63454633
Alopecia 46.91 11.58 65 33180 337471 63118306
Hepatic enzyme increased 46.41 11.58 24 33221 202304 63253473
Lower respiratory tract infection 46.29 11.58 7 33238 132300 63323477
Atrioventricular block second degree 44.67 11.58 27 33218 3887 63451890
Acute lung injury 44.65 11.58 20 33225 1551 63454226
Non-cardiogenic pulmonary oedema 44.11 11.58 16 33229 715 63455062
Bundle branch block right 43.38 11.58 29 33216 4969 63450808
Rash 43.22 11.58 150 33095 560721 62895056
Vasoplegia syndrome 43.15 11.58 20 33225 1679 63454098
Cardiac failure congestive 42.09 11.58 125 33120 92308 63363469
Myocardial stunning 41.89 11.58 11 33234 162 63455615
Rhythm idioventricular 41.62 11.58 12 33233 254 63455523
Rheumatoid arthritis 41.51 11.58 43 33202 253776 63202001
Coma 41.44 11.58 99 33146 64265 63391512
Large intestine polyp 40.82 11.58 34 33211 8123 63447654
Hyperkalaemia 40.01 11.58 88 33157 54115 63401662
Abdominal discomfort 39.58 11.58 67 33178 320818 63134959
Swelling 39.29 11.58 52 33193 275326 63180451
Pain 39.10 11.58 228 33017 740400 62715377
Acute kidney injury 38.61 11.58 253 32992 263162 63192615
Drug intolerance 38.48 11.58 64 33181 308597 63147180
Discomfort 38.16 11.58 20 33225 167354 63288423
Extrapyramidal disorder 36.94 11.58 40 33205 13244 63442533
Suicide attempt 35.30 11.58 90 33155 60828 63394949
Fear of disease 34.80 11.58 16 33229 1318 63454459
Duodenal ulcer perforation 34.53 11.58 3 33242 87206 63368571
Product coating issue 34.36 11.58 8 33237 69 63455708
Device pacing issue 32.53 11.58 8 33237 89 63455688
Respiratory depression 32.51 11.58 38 33207 13677 63442100
Atrial fibrillation 32.45 11.58 134 33111 116502 63339275
Body temperature decreased 32.01 11.58 46 33199 20273 63435504
Cardiac failure 31.03 11.58 110 33135 89032 63366745
Suspected suicide 30.04 11.58 26 33219 6542 63449235
Neonatal respiratory distress 28.99 11.58 10 33235 385 63455392
Myocardial ischaemia 27.80 11.58 34 33211 12825 63442952
Hyperglycaemia 27.60 11.58 65 33180 41802 63413975
Pulseless electrical activity 27.02 11.58 26 33219 7495 63448282
Hypersensitivity 26.97 11.58 72 33173 292613 63163164
Rhabdomyolysis 26.58 11.58 66 33179 43885 63411892
Mixed liver injury 26.35 11.58 21 33224 4714 63451063
Anion gap 25.87 11.58 13 33232 1304 63454473
Atrioventricular dissociation 25.83 11.58 8 33237 218 63455559
Supraventricular tachycardia 25.00 11.58 34 33211 14237 63441540
Tongue oedema 24.80 11.58 20 33225 4566 63451211
Infection 24.59 11.58 52 33193 229121 63226656
Drug hypersensitivity 24.26 11.58 259 32986 310428 63145349
Arrhythmia 23.83 11.58 58 33187 38082 63417695
Ventricular extrasystoles 23.82 11.58 30 33215 11657 63444120
Cardio-respiratory arrest 23.51 11.58 77 33168 59882 63395895
Irritable bowel syndrome 23.44 11.58 7 33238 82405 63373372
Cerebrovascular accident 23.21 11.58 115 33130 107909 63347868
Melaena 23.20 11.58 50 33195 30315 63425462
Cough 22.84 11.58 244 33001 292499 63163278
Arthralgia 22.78 11.58 190 33055 569520 62886257
Clinically isolated syndrome 22.65 11.58 5 33240 33 63455744
Lactic acidosis 22.63 11.58 57 33188 38230 63417547
Impaired healing 22.28 11.58 13 33232 102529 63353248
Electrolyte imbalance 21.36 11.58 38 33207 20038 63435739
Depressed level of consciousness 21.08 11.58 76 33169 62002 63393775
Product monitoring error 20.90 11.58 18 33227 4498 63451279
Tricuspid valve disease 20.80 11.58 7 33238 250 63455527
Gastrointestinal disorder 19.50 11.58 24 33221 131215 63324562
Syncope 19.18 11.58 116 33129 117269 63338508
Hyponatraemic syndrome 18.81 11.58 8 33237 547 63455230
Exposure during pregnancy 18.67 11.58 33 33212 155514 63300263
Placental calcification 18.45 11.58 4 33241 24 63455753
Gallbladder oedema 18.19 11.58 6 33239 201 63455576
Maternal exposure during pregnancy 18.16 11.58 57 33188 220005 63235772
Hypotonia neonatal 17.95 11.58 10 33235 1236 63454541
Cholestatic liver injury 17.65 11.58 13 33232 2597 63453180
Low cardiac output syndrome 17.43 11.58 7 33238 414 63455363
Musculoskeletal stiffness 17.30 11.58 45 33200 184573 63271204
Cardiac failure acute 17.15 11.58 23 33222 9500 63446277
Blood phosphorus decreased 17.15 11.58 16 33229 4437 63451340
Mobility decreased 17.13 11.58 23 33222 121136 63334641
Poisoning deliberate 17.09 11.58 25 33220 11193 63444584
Renal impairment 16.85 11.58 91 33154 88264 63367513
Pallor 16.51 11.58 44 33201 30524 63425253
Sinus node dysfunction 16.46 11.58 16 33229 4669 63451108
Therapeutic product effect incomplete 16.44 11.58 25 33220 125031 63330746
Accidental overdose 16.25 11.58 37 33208 23272 63432505
Normocytic anaemia 16.22 11.58 11 33234 1929 63453848
Sinus arrest 16.18 11.58 11 33234 1938 63453839
Blister 16.07 11.58 27 33218 129787 63325990
Product used for unknown indication 15.85 11.58 7 33238 525 63455252
Medication overuse headache 15.72 11.58 8 33237 824 63454953
Liver injury 15.72 11.58 6 33239 60514 63395263
Hypertrophic cardiomyopathy 15.71 11.58 10 33235 1577 63454200
Hip fracture 15.49 11.58 42 33203 29432 63426345
Breast enlargement 15.43 11.58 10 33235 1626 63454151
Metastases to retroperitoneum 15.41 11.58 5 33240 159 63455618
Embolic stroke 15.38 11.58 14 33231 3762 63452015
Loss of personal independence in daily activities 15.30 11.58 17 33228 97273 63358504
Renal tubular disorder 15.15 11.58 12 33233 2670 63453107
Salivary gland calculus 15.01 11.58 5 33240 173 63455604
Cardiotoxicity 14.62 11.58 20 33225 8418 63447359
Pyrexia 14.53 11.58 167 33078 470311 62985466
Exfoliative rash 14.52 11.58 12 33233 2835 63452942
Malabsorption 14.48 11.58 14 33231 4058 63451719
Apraxia 14.46 11.58 10 33235 1811 63453966
Febrile neutropenia 14.33 11.58 25 33220 118424 63337353
Stress cardiomyopathy 14.31 11.58 21 33224 9429 63446348
Hepatitis A antibody abnormal 14.28 11.58 4 33241 76 63455701
Interspinous osteoarthritis 14.28 11.58 4 33241 76 63455701
Blood cholesterol increased 14.18 11.58 17 33228 94015 63361762
Dizziness 14.09 11.58 309 32936 429616 63026161
Tachycardia 14.07 11.58 108 33137 118048 63337729
Type 2 diabetes mellitus 14.01 11.58 8 33237 63860 63391917
Product physical issue 13.85 11.58 15 33230 4965 63450812
Pneumonia chlamydial 13.81 11.58 4 33241 86 63455691
Hip arthroplasty 13.63 11.58 4 33241 47642 63408135
Haemarthrosis 13.43 11.58 12 33233 3149 63452628
Ventricular fibrillation 13.32 11.58 23 33222 11844 63443933
Circulatory collapse 13.32 11.58 33 33212 21905 63433872
Malignant neoplasm progression 13.30 11.58 14 33231 82107 63373670
Toxic skin eruption 13.21 11.58 24 33221 12861 63442916
Rhabdomyosarcoma 12.91 11.58 4 33241 109 63455668
Blood pressure immeasurable 12.79 11.58 8 33237 1224 63454553
Herbal interaction 12.61 11.58 4 33241 118 63455659
Cerebral haemorrhage 12.53 11.58 40 33205 30689 63425088
Sinoatrial block 12.45 11.58 7 33238 881 63454896
Periorbital oedema 12.24 11.58 15 33230 5669 63450108
Pulmonary oedema 12.20 11.58 59 33186 54814 63400963
Malignant neoplasm of ampulla of Vater 12.15 11.58 3 33242 34 63455743
Poor quality sleep 12.12 11.58 30 33215 19905 63435872
Respiratory failure 12.07 11.58 93 33152 101765 63354012
Haemorrhage subcutaneous 12.04 11.58 11 33234 2972 63452805
Aortic valve disease mixed 11.91 11.58 3 33242 37 63455740
Spinal stenosis 11.89 11.58 25 33220 14900 63440877
Electrocardiogram T wave abnormal 11.83 11.58 10 33235 2437 63453340
Ventricular tachyarrhythmia 11.77 11.58 4 33241 147 63455630
Coma scale abnormal 11.75 11.58 14 33231 5139 63450638
Articular calcification 11.70 11.58 4 33241 150 63455627

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 479.65 13.54 402 17900 97766 34840863
Cardiogenic shock 279.91 13.54 174 18128 26444 34912185
Bradycardia 250.23 13.54 249 18053 75169 34863460
Toxicity to various agents 145.34 13.54 322 17980 200040 34738589
Hypotension 118.72 13.54 317 17985 221332 34717297
Intentional overdose 100.41 13.54 119 18183 43555 34895074
Shock 82.13 13.54 81 18221 24098 34914531
Atrioventricular block complete 80.76 13.54 54 18248 9265 34929364
Drug interaction 70.91 13.54 269 18033 225677 34712952
Cerebral artery thrombosis 66.13 13.54 22 18280 758 34937871
BRASH syndrome 65.26 13.54 20 18282 526 34938103
Vasoplegia syndrome 63.75 13.54 27 18275 1829 34936800
Brain scan abnormal 63.53 13.54 22 18280 858 34937771
Overdose 63.11 13.54 144 18158 90915 34847714
Areflexia 51.12 13.54 27 18275 3004 34935625
Coma 46.81 13.54 85 18217 45593 34893036
Hemiplegia 43.33 13.54 33 18269 6939 34931690
Nodal rhythm 43.04 13.54 19 18283 1424 34937205
Compartment syndrome 40.19 13.54 23 18279 2995 34935634
Oesophageal ulcer haemorrhage 39.99 13.54 11 18291 195 34938434
Febrile neutropenia 36.55 13.54 13 18289 136836 34801793
Antiacetylcholine receptor antibody positive 35.72 13.54 8 18294 57 34938572
Pacemaker generated rhythm 35.13 13.54 8 18294 62 34938567
Coma scale abnormal 34.18 13.54 23 18279 3985 34934644
Cardiac arrest 33.84 13.54 119 18183 96040 34842589
Ischaemic stroke 32.78 13.54 44 18258 18206 34920423
Sinus bradycardia 32.56 13.54 37 18265 12926 34925703
Prostatic adenoma 32.28 13.54 9 18293 168 34938461
Pseudomonal sepsis 31.80 13.54 21 18281 3526 34935103
Hyperkalaemia 29.90 13.54 92 18210 69297 34869332
Poisoning deliberate 29.87 13.54 28 18274 7816 34930813
Pulse absent 28.65 13.54 24 18278 5779 34932850
Supraventricular tachycardia 28.38 13.54 32 18270 11085 34927544
Normochromic normocytic anaemia 28.21 13.54 21 18281 4266 34934363
Embolic stroke 27.50 13.54 21 18281 4433 34934196
Acute respiratory distress syndrome 27.45 13.54 49 18253 25920 34912709
Rhythm idioventricular 26.91 13.54 9 18293 315 34938314
Lactic acidosis 26.30 13.54 57 18245 34715 34903914
Neuromyopathy 25.73 13.54 12 18290 1022 34937607
Superinfection 25.26 13.54 16 18286 2503 34936126
Cerebral haematoma 24.70 13.54 20 18282 4595 34934034
Suicide attempt 23.95 13.54 59 18243 39057 34899572
Left ventricle outflow tract obstruction 23.52 13.54 7 18295 166 34938463
Cardiorenal syndrome 23.12 13.54 10 18292 713 34937916
Xanthelasma 22.44 13.54 6 18296 95 34938534
Mallory-Weiss syndrome 22.41 13.54 12 18290 1372 34937257
Cluster headache 22.02 13.54 9 18293 557 34938072
Cerebral infarction 21.91 13.54 46 18256 27409 34911220
Nodal arrhythmia 21.26 13.54 10 18292 868 34937761
Tobacco abuse 20.51 13.54 8 18294 438 34938191
Palpitations 20.07 13.54 56 18246 39930 34898699
Pyrexia 20.05 13.54 98 18204 332915 34605714
Atrioventricular block first degree 19.91 13.54 20 18282 6072 34932557
Facial paralysis 19.46 13.54 26 18276 10708 34927921
Therapeutic drug monitoring analysis incorrectly performed 19.13 13.54 7 18295 321 34938308
Acidosis 19.06 13.54 26 18276 10919 34927710
Alkalosis hypochloraemic 19.05 13.54 7 18295 325 34938304
Acute kidney injury 18.91 13.54 243 18059 304745 34633884
Antineutrophil cytoplasmic antibody increased 18.45 13.54 4 18298 24 34938605
Medication error 18.30 13.54 41 18261 25524 34913105
Hyperlactacidaemia 18.14 13.54 14 18288 3002 34935627
Prothrombin time ratio decreased 17.97 13.54 7 18295 382 34938247
Diarrhoea 17.51 13.54 126 18176 389786 34548843
Neutropenia 17.31 13.54 35 18267 156743 34781886
Pallor 17.28 13.54 40 18262 25440 34913189
Haemoglobin decreased 17.02 13.54 23 18279 120749 34817880
Disease progression 16.89 13.54 19 18283 108058 34830571
Labelled drug-drug interaction medication error 16.84 13.54 29 18273 14910 34923719
Heart rate abnormal 16.80 13.54 11 18291 1820 34936809
Lymphoedema 16.62 13.54 15 18287 3988 34934641
Arrhythmia 15.90 13.54 48 18254 35760 34902869
Haemodynamic instability 15.65 13.54 22 18280 9501 34929128
Erythromelalgia 15.62 13.54 4 18298 53 34938576
Internal haemorrhage 15.48 13.54 16 18286 5025 34933604
Atrioventricular block 15.34 13.54 20 18282 8043 34930586
Wrong patient received product 15.26 13.54 12 18290 2642 34935987
Neck injury 15.24 13.54 9 18293 1242 34937387
Intensive care 15.22 13.54 7 18295 577 34938052
Hyperparathyroidism primary 15.18 13.54 5 18297 167 34938462
Neutrophil count decreased 15.17 13.54 4 18298 51100 34887529
Pain 14.89 13.54 56 18246 204619 34734010
Defect conduction intraventricular 14.76 13.54 6 18296 366 34938263
Disturbance in attention 14.69 13.54 38 18264 25907 34912722
Myofascial pain syndrome 14.69 13.54 6 18296 371 34938258
Victim of crime 14.59 13.54 6 18296 377 34938252
Non-cardiogenic pulmonary oedema 14.40 13.54 7 18295 654 34937975
Thalamus haemorrhage 14.30 13.54 8 18294 997 34937632
Gravitational oedema 14.21 13.54 7 18295 673 34937956
Anuria 14.20 13.54 22 18280 10363 34928266
Anaphylactic reaction 14.06 13.54 43 18259 32258 34906371
Idiopathic intracranial hypertension 14.01 13.54 7 18295 694 34937935
Sudden death 13.95 13.54 27 18275 15174 34923455
Rebound tachycardia 13.70 13.54 3 18299 19 34938610
Benign prostatic hyperplasia 13.62 13.54 26 18276 14469 34924160
Atrial fibrillation 13.58 13.54 110 18192 122283 34816346

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1303.32 11.00 1099 44911 244668 79453710
Bradycardia 691.43 11.00 594 45416 134963 79563415
Cardiogenic shock 544.58 11.00 325 45685 41589 79656789
Toxicity to various agents 421.01 11.00 818 45192 420722 79277656
Hypotension 366.90 11.00 793 45217 439524 79258854
Atrioventricular block complete 300.25 11.00 160 45850 16450 79681928
Drug interaction 256.55 11.00 666 45344 414517 79283861
BRASH syndrome 236.92 11.00 64 45946 953 79697425
Intentional overdose 188.20 11.00 267 45743 105693 79592685
Overdose 174.08 11.00 350 45660 183856 79514522
Atrioventricular block 164.56 11.00 102 45908 13939 79684439
Shock 155.99 11.00 157 45853 43391 79654987
Metabolic acidosis 132.03 11.00 198 45812 82331 79616047
Sinus bradycardia 119.04 11.00 106 45904 25141 79673237
Nodal rhythm 117.80 11.00 50 45960 3085 79695293
Anuria 117.12 11.00 97 45913 20866 79677512
Neovascularisation 105.65 11.00 36 45974 1209 79697169
Atrioventricular block first degree 105.60 11.00 74 45936 12417 79685961
Acute respiratory distress syndrome 104.42 11.00 128 45882 43939 79654439
Vasoplegia syndrome 101.33 11.00 47 45963 3583 79694795
Cardiac arrest 99.70 11.00 270 45740 171826 79526552
Electrocardiogram QRS complex prolonged 93.50 11.00 65 45945 10768 79687610
Electrocardiogram QT prolonged 89.18 11.00 175 45835 90211 79608167
Coma 86.45 11.00 184 45826 100465 79597913
Drug ineffective for unapproved indication 74.98 11.00 118 45892 51120 79647258
Joint swelling 72.57 11.00 38 45972 288608 79409770
Synovitis 70.73 11.00 4 46006 150730 79547648
Labelled drug-drug interaction medication error 64.99 11.00 80 45930 27570 79670808
Rhythm idioventricular 64.75 11.00 21 45989 603 79697775
Nodal arrhythmia 59.57 11.00 27 45983 1951 79696427
Cryopyrin associated periodic syndrome 56.37 11.00 17 45993 382 79697996
Hyperkalaemia 56.01 11.00 169 45841 114229 79584149
Infusion related reaction 55.40 11.00 32 45978 230205 79468173
Non-cardiogenic pulmonary oedema 53.33 11.00 23 45987 1476 79696902
Systemic lupus erythematosus 51.76 11.00 5 46005 121144 79577234
Brain scan abnormal 50.97 11.00 21 45989 1202 79697176
Febrile neutropenia 50.26 11.00 36 45974 230963 79467415
Suicide attempt 49.87 11.00 132 45878 82800 79615578
Cerebral artery thrombosis 49.45 11.00 20 45990 1091 79697287
Therapeutic product effect decreased 48.44 11.00 17 45993 163846 79534532
Paradoxical drug reaction 48.15 11.00 37 45973 7148 79691230
Supraventricular tachycardia 47.52 11.00 60 45950 21210 79677168
Arthropathy 46.47 11.00 22 45988 177089 79521289
Hepatic enzyme increased 45.93 11.00 24 45986 182586 79515792
Pain 45.10 11.00 231 45779 703571 78994807
Acute kidney injury 43.80 11.00 475 45535 518929 79179449
Pemphigus 42.83 11.00 4 46006 99578 79598800
Lower respiratory tract infection 42.55 11.00 11 45999 129209 79569169
Glossodynia 42.26 11.00 5 46005 103332 79595046
Rheumatoid arthritis 42.15 11.00 35 45975 208435 79489943
Coma scale abnormal 42.02 11.00 37 45973 8641 79689737
Lactic acidosis 41.30 11.00 111 45899 70248 79628130
Embolic stroke 41.20 11.00 35 45975 7791 79690587
Poisoning deliberate 40.31 11.00 52 45958 18776 79679602
Myocardial stunning 38.98 11.00 11 45999 194 79698184
Atrial fibrillation 38.60 11.00 220 45790 197666 79500712
Pericarditis 38.12 11.00 7 46003 104229 79594149
Ischaemic stroke 37.43 11.00 68 45942 33063 79665315
Atrioventricular dissociation 37.36 11.00 12 45998 334 79698044
Alopecia 35.46 11.00 49 45961 231306 79467072
Prostatic adenoma 34.95 11.00 9 46001 110 79698268
Pacemaker generated rhythm 34.02 11.00 8 46002 65 79698313
Bundle branch block right 33.90 11.00 37 45973 11214 79687164
Areflexia 33.84 11.00 27 45983 5507 79692871
Fear of disease 33.81 11.00 16 45994 1276 79697102
Cardiac failure congestive 33.69 11.00 167 45843 142235 79556143
Antiacetylcholine receptor antibody positive 33.59 11.00 8 46002 69 79698309
Pyrexia 33.37 11.00 242 45768 678467 79019911
Swelling 33.11 11.00 46 45964 216665 79481713
Cerebral infarction 33.02 11.00 78 45932 45598 79652780
Acute lung injury 32.52 11.00 21 45989 3079 79695299
Infection 32.44 11.00 56 45954 241656 79456722
Product coating issue 32.26 11.00 8 46002 83 79698295
Left ventricle outflow tract obstruction 31.39 11.00 11 45999 402 79697976
Hyperglycaemia 30.81 11.00 100 45910 70235 79628143
Oesophageal ulcer haemorrhage 30.61 11.00 12 45998 603 79697775
Sinus node dysfunction 29.85 11.00 29 45981 7672 79690706
Wound 29.60 11.00 15 45995 116164 79582214
Cardiac failure 29.43 11.00 171 45839 154671 79543707
Compartment syndrome 29.39 11.00 24 45986 5058 79693320
Atrioventricular block second degree 29.22 11.00 28 45982 7284 79691094
Large intestine polyp 28.63 11.00 36 45974 12672 79685706
Mixed liver injury 28.37 11.00 28 45982 7550 79690828
Product monitoring error 28.08 11.00 30 45980 8876 79689502
Duodenal ulcer perforation 27.58 11.00 3 46007 66208 79632170
Pulseless electrical activity 27.07 11.00 37 45973 14123 79684255
Disease progression 26.33 11.00 41 45969 184321 79514057
Arrhythmia 25.83 11.00 86 45924 61186 79637192
Suspected suicide 25.50 11.00 31 45979 10545 79687833
Discomfort 25.49 11.00 21 45989 125596 79572782
Pallor 25.47 11.00 75 45935 49987 79648391
Cerebrovascular accident 25.41 11.00 165 45845 155127 79543251
Rhabdomyolysis 25.14 11.00 122 45888 103009 79595369
Pulse absent 24.99 11.00 30 45980 10073 79688305
Low cardiac output syndrome 24.50 11.00 12 45998 1033 79697345
Sinoatrial block 24.36 11.00 13 45997 1338 79697040
Hemiplegia 24.09 11.00 36 45974 14903 79683475
Musculoskeletal stiffness 23.98 11.00 40 45970 174968 79523410
Arthralgia 23.43 11.00 214 45796 571589 79126789
Hypersensitivity 23.04 11.00 76 45934 262163 79436215
Sinus arrest 22.85 11.00 18 45992 3604 79694774
Cardio-respiratory arrest 22.71 11.00 123 45887 108387 79589991
Malignant neoplasm progression 22.69 11.00 27 45983 135963 79562415
Neuromyopathy 22.63 11.00 13 45997 1545 79696833
Periorbital oedema 22.52 11.00 26 45984 8376 79690002
Hypertrophic cardiomyopathy 22.47 11.00 15 45995 2325 79696053
Rash 22.18 11.00 220 45790 578138 79120240
Cluster headache 22.05 11.00 11 45999 985 79697393
Pseudomonal sepsis 21.62 11.00 22 45988 6152 79692226
Acidosis 21.61 11.00 40 45970 19722 79678656
Neutrophil count decreased 21.28 11.00 14 45996 93945 79604433
Clinically isolated syndrome 21.22 11.00 5 46005 41 79698337
Myocardial ischaemia 21.14 11.00 46 45964 25473 79672905
Irritable bowel syndrome 21.06 11.00 5 46005 62236 79636142
Tongue oedema 20.74 11.00 23 45987 7094 79691284
Hepatocellular injury 20.24 11.00 67 45943 47526 79650852
Device pacing issue 20.10 11.00 6 46004 130 79698248
Internal haemorrhage 19.86 11.00 25 45985 8808 79689570
Abdominal discomfort 19.80 11.00 76 45934 250651 79447727
Placental calcification 19.61 11.00 4 46006 15 79698363
Neutropenia 19.18 11.00 93 45917 287617 79410761
Pancytopenia 19.10 11.00 42 45968 165703 79532675
Blood pressure immeasurable 19.04 11.00 13 45997 2091 79696287
Gallbladder oedema 18.96 11.00 7 46003 298 79698080
Contraindicated product administered 18.92 11.00 39 45971 157499 79540879
Extrapyramidal disorder 18.92 11.00 41 45969 22638 79675740
Alkalosis hypochloraemic 18.81 11.00 8 46002 496 79697882
Xanthelasma 18.75 11.00 6 46004 165 79698213
Anion gap 18.62 11.00 13 45997 2168 79696210
Gastrointestinal disorder 18.59 11.00 26 45984 122179 79576199
Drug intolerance 18.41 11.00 84 45926 264035 79434343
Medication error 18.04 11.00 83 45927 68559 79629819
Hyperlactacidaemia 17.91 11.00 19 45991 5576 79692802
Cardiotoxicity 17.64 11.00 28 45982 12211 79686167
Bundle branch block left 17.51 11.00 27 45983 11486 79686892
Facial paralysis 17.47 11.00 38 45972 21034 79677344
Body temperature decreased 17.16 11.00 49 45961 32096 79666282
Pulmonary oedema 17.11 11.00 98 45912 88156 79610222
Cerebral haematoma 17.10 11.00 22 45988 7920 79690458
Tachycardia 17.02 11.00 167 45843 177601 79520777
Ventricular extrasystoles 16.87 11.00 36 45974 19668 79678710
Haematoma 16.71 11.00 67 45943 52128 79646250
Platelet count decreased 16.69 11.00 57 45953 194607 79503771
Mobility decreased 16.66 11.00 28 45982 122147 79576231
Tricuspid valve disease 16.60 11.00 7 46003 425 79697953
Haemodynamic instability 16.34 11.00 33 45977 17349 79681029
Palpitations 16.32 11.00 127 45883 126483 79571895
Electrocardiogram T wave abnormal 16.25 11.00 15 45995 3723 79694655
Normochromic normocytic anaemia 16.01 11.00 21 45989 7706 79690672
Folliculitis 15.93 11.00 6 46004 55374 79643004
Exfoliative rash 15.84 11.00 15 45995 3844 79694534
Blood cholesterol increased 15.77 11.00 15 45995 83705 79614673
Alanine aminotransferase increased 15.77 11.00 45 45965 162525 79535853
Weight increased 15.54 11.00 95 45915 277291 79421087
Mallory-Weiss syndrome 15.52 11.00 13 45997 2839 79695539
Hyponatraemic syndrome 15.47 11.00 8 46002 772 79697606
Wrong patient received product 15.35 11.00 16 45994 4602 79693776
Haemoglobin decreased 15.26 11.00 71 45939 222048 79476330
Impaired healing 15.05 11.00 17 45993 87638 79610740
Cough 15.02 11.00 296 45714 366493 79331885
Syncope 15.01 11.00 164 45846 179285 79519093
Cardiorenal syndrome 14.81 11.00 10 46000 1579 79696799
Hip fracture 14.62 11.00 45 45965 30716 79667662
Cerebral haemorrhage 14.61 11.00 69 45941 57604 79640774
Superinfection 14.56 11.00 16 45994 4886 79693492
Electrolyte imbalance 14.52 11.00 45 45965 30836 79667542
Loss of personal independence in daily activities 14.46 11.00 23 45987 102557 79595821
Medication overuse headache 14.30 11.00 8 46002 904 79697474
Malabsorption 14.21 11.00 16 45994 5016 79693362
Respiratory failure 14.07 11.00 163 45847 180748 79517630
Tachycardia induced cardiomyopathy 13.94 11.00 5 46005 196 79698182
Interspinous osteoarthritis 13.89 11.00 4 46006 76 79698302
Hepatitis A antibody abnormal 13.89 11.00 4 46006 76 79698302
Altered state of consciousness 13.82 11.00 56 45954 43766 79654612
Mucosal inflammation 13.71 11.00 14 45996 75566 79622812
Tobacco abuse 13.57 11.00 8 46002 998 79697380
Dyspnoea 13.56 11.00 614 45396 856411 78841967
Melaena 13.40 11.00 70 45940 60820 79637558
Therapeutic drug monitoring analysis incorrectly performed 13.22 11.00 7 46003 709 79697669
Haemorrhage subcutaneous 13.09 11.00 15 45995 4794 79693584
Tobacco user 12.84 11.00 7 46003 752 79697626
Intentional product use issue 12.72 11.00 45 45965 152067 79546311
Victim of crime 12.64 11.00 6 46004 482 79697896
Depressed level of consciousness 12.48 11.00 97 45913 96555 79601823
Drug dependence 12.44 11.00 4 46006 40765 79657613
Defect conduction intraventricular 12.35 11.00 6 46004 507 79697871
Disturbance in attention 12.31 11.00 60 45950 50741 79647637
Pneumonia chlamydial 12.23 11.00 4 46006 118 79698260
Herpes zoster 12.08 11.00 22 45988 93061 79605317
Heart rate abnormal 11.84 11.00 16 45994 6041 79692337
Respiratory depression 11.84 11.00 39 45971 27591 79670787
Malignant neoplasm of ampulla of Vater 11.78 11.00 3 46007 35 79698343
Ascites 11.57 11.00 16 45994 75546 79622832
Thalamus haemorrhage 11.55 11.00 9 46001 1773 79696605
Prothrombin time ratio decreased 11.55 11.00 7 46003 918 79697460
Haematocrit decreased 11.53 11.00 11 45999 61301 79637077
Pneumonia aspiration 11.47 11.00 72 45938 66895 79631483
White blood cell count decreased 11.33 11.00 63 45947 188225 79510153
Cardiac failure acute 11.24 11.00 30 45980 18899 79679479
Chronic obstructive pulmonary disease 11.18 11.00 86 45924 85333 79613045
Psychotic disorder 11.07 11.00 5 46005 41397 79656981
Rhabdomyosarcoma 11.07 11.00 4 46006 160 79698218

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08DA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Phenylalkylamine derivatives
ATC C08DA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Phenylalkylamine derivatives
ATC C09BB10 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175566 Calcium Channel Blocker
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:62872 quinoline oxidase inhibitors
CHEBI has role CHEBI:77255 lethal toxin inhibitors
CHEBI has role CHEBI:77745 meprin-a inhibitors
CHEBI has role CHEBI:77747 EC 3.6.3.1 inhibitors
CHEBI has role CHEBI:77748 steroid-transporting ATPase inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
FDA MoA N0000190114 Cytochrome P450 3A Inhibitors
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Paroxysmal supraventricular tachycardia indication 67198005
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Prevention of Paroxysmal Supraventricular Tachycardia indication
Cardioversion of Atrial Fibrillation indication
Diastolic heart failure off-label use 418304008 DOID:9775
Cluster Headache Prevention off-label use
Hyperkalemia contraindication 14140009
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Acute cerebrovascular insufficiency contraindication 29322000
Sick sinus syndrome contraindication 36083008 DOID:13884
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Low cardiac output syndrome contraindication 44088000
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Lown-Ganong-Levine syndrome contraindication 55475008 DOID:13087
Aortic valve stenosis contraindication 60573004 DOID:1712
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Left heart failure contraindication 85232009
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Second degree atrioventricular block contraindication 195042002
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
First Degree Atrioventricular Heart Block contraindication
Neuromuscular Transmission Deficiency contraindication
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel BLOCKER UNKNOWN IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER IC50 6 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 8 CHEMBL
Cytochrome P450 3A4 Enzyme INHIBITOR Ki 6.22 IUPHAR
Multidrug resistance protein 1 Transporter Ki 6.52 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.90 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 5.76 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.85 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 6.98 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.81 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 7.20 DRUG MATRIX
Histamine H2 receptor GPCR Ki 5.59 DRUG MATRIX
Aldehyde oxidase Enzyme IC50 5.46 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.07 DRUG MATRIX
Multidrug resistance-associated protein 1 Transporter Ki 4.88 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter EC50 4.43 CHEMBL
Carbonic anhydrase 1 Enzyme WOMBAT-PK
G protein-activated inward rectifier potassium channel 2 Ion channel WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER Ki 4.49 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 10 Ion channel BLOCKER IC50 4.30 IUPHAR
Potassium voltage-gated channel subfamily A member 3 Ion channel IC50 5.10 CHEMBL
Potassium voltage-gated channel subfamily C member 2 Ion channel EC50 4.90 WOMBAT-PK
Solute carrier family 22 member 1 Transporter IC50 5.17 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 4.35 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7 Ion channel Kd 4.80 WOMBAT-PK
Solute carrier family 22 member 2 Transporter IC50 4.07 WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.48 CHEMBL
Equilibrative nucleoside transporter 4 Transporter INHIBITOR Ki 4.73 IUPHAR
Two pore calcium channel protein 1 Ion channel BLOCKER IC50 4.64 IUPHAR
Sodium channel protein type 5 subunit alpha Ion channel WOMBAT-PK
Two pore calcium channel protein 2 Ion channel BLOCKER IC50 5 IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 6.66 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.03 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.76 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 5.68 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.52 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 6 CHEMBL
Translocator protein Membrane receptor IC50 8.85 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 7.41 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel Ki 7.24 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR EC50 4.51 CHEMBL
Voltage-gated L-type calcium channel Ion channel IC50 8.43 CHEMBL
Chloroquine resistance transporter Transporter IC50 4.52 CHEMBL
Potassium voltage-gated channel subfamily C member 2 Ion channel BLOCKER EC50 4.90 IUPHAR

External reference:

IDSource
4019969 VUID
N0000148054 NUI
D00619 KEGG_DRUG
152-11-4 SECONDARY_CAS_RN
4018128 VANDF
4019969 VANDF
C0042523 UMLSCUI
CHEBI:9948 CHEBI
CHEMBL6966 ChEMBL_ID
CHEMBL1280 ChEMBL_ID
D014700 MESH_DESCRIPTOR_UI
DB00661 DRUGBANK_ID
2406 IUPHAR_LIGAND_ID
2122 INN_ID
CJ0O37KU29 UNII
2520 PUBCHEM_CID
11170 RXNORM
5670 MMSL
757 MMSL
d00048 MMSL
000709 NDDF
004515 NDDF
14340003 SNOMEDCT_US
372754009 SNOMEDCT_US
47898004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-1891 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-1901 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-1911 TABLET, FILM COATED, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2712 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2712 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2712 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2818 TABLET, FILM COATED, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2818 TABLET, FILM COATED, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2818 TABLET, FILM COATED, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2924 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2924 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
CALAN SR HUMAN PRESCRIPTION DRUG LABEL 1 0025-2924 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6320 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6320 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6380 CAPSULE, EXTENDED RELEASE 180 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6380 CAPSULE, EXTENDED RELEASE 180 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6440 CAPSULE, EXTENDED RELEASE 240 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6440 CAPSULE, EXTENDED RELEASE 240 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9966 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9966 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
VERAPAMIL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9967 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
VERAPAMIL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9967 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9968 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9968 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1144 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 17 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1144 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 17 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1144 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 17 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1144 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 17 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4011 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 17 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4011 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 17 sections