venlafaxine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2813 93413-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • venlafaxine
  • (+/-)-Venlafaxine
  • velafax
  • venlafaxin
  • venlafexine
  • venlafaxine hydrochloride
  • effexor
  • WY-45,030
  • venlafaxine HCl
A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
  • Molecular weight: 277.41
  • Formula: C17H27NO2
  • CLOGP: 3.27
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.70
  • ALOGS: -3.08
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 572 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.59 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 45 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 14 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.73 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1993 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1293.24 9.76 1884 167993 130005 50305242
Drug withdrawal syndrome 1173.50 9.76 838 169039 24243 50411004
Intentional overdose 921.39 9.76 1092 168785 61412 50373835
Suicidal ideation 779.06 9.76 945 168932 54440 50380807
Serotonin syndrome 778.20 9.76 653 169224 24060 50411187
Suicide attempt 723.22 9.76 880 168997 50852 50384395
Toxicity to various agents 685.77 9.76 1907 167970 210592 50224655
Overdose 547.46 9.76 1102 168775 98625 50336622
Intentional self-injury 491.17 9.76 490 169387 22622 50412625
Withdrawal syndrome 440.04 9.76 408 169469 17182 50418065
Drug abuse 417.49 9.76 733 169144 59113 50376134
Drug interaction 395.52 9.76 1518 168359 198103 50237144
Agitation 330.56 9.76 621 169256 52763 50382484
Joint swelling 314.12 9.76 220 169657 245066 50190181
Contraindicated product administered 311.28 9.76 61 169816 148897 50286350
Depression 305.60 9.76 1231 168646 164192 50271055
Systemic lupus erythematosus 301.49 9.76 54 169823 140568 50294679
Poisoning deliberate 299.68 9.76 233 169644 7679 50427568
Sopor 293.69 9.76 348 169529 19531 50415716
Synovitis 282.57 9.76 40 169837 123825 50311422
Hand deformity 278.16 9.76 14 169863 100185 50335062
Coma 276.13 9.76 598 169279 56281 50378966
Tremor 269.78 9.76 924 168953 113979 50321268
Anxiety 267.67 9.76 1243 168634 176363 50258884
Mydriasis 247.59 9.76 237 169640 10390 50424857
Glossodynia 242.09 9.76 47 169830 115522 50319725
Crying 240.29 9.76 319 169558 20097 50415150
Arthropathy 233.80 9.76 119 169758 157787 50277460
Hyperhidrosis 222.11 9.76 733 169144 88693 50346554
Infusion related reaction 211.77 9.76 156 169721 169401 50265846
Pericarditis 206.31 9.76 15 169862 78674 50356573
Somnolence 200.71 9.76 1039 168838 153946 50281301
Rash 200.27 9.76 774 169103 436697 49998550
Electrocardiogram QT prolonged 196.50 9.76 495 169382 51391 50383856
Seizure 188.60 9.76 840 169037 117034 50318213
Alopecia 185.56 9.76 337 169540 244710 50190537
Swelling 183.85 9.76 243 169634 200629 50234618
Rheumatoid arthritis 175.39 9.76 255 169622 202295 50232952
Wound 173.33 9.76 69 169808 105725 50329522
Abdominal discomfort 172.32 9.76 322 169555 231319 50203928
Hypersensitivity 170.03 9.76 288 169589 214873 50220374
Treatment failure 168.78 9.76 129 169748 137508 50297739
Akathisia 168.41 9.76 171 169706 8058 50427189
Disturbance in attention 161.83 9.76 337 169540 30849 50404398
Irritability 160.35 9.76 318 169559 28108 50407139
Depressed mood 155.21 9.76 349 169528 33674 50401573
Anger 153.69 9.76 190 169687 11143 50424104
Panic attack 153.42 9.76 251 169626 19091 50416156
Nightmare 153.06 9.76 227 169650 15859 50419388
Discomfort 151.15 9.76 88 169789 108292 50326955
Feeling abnormal 147.22 9.76 819 169058 124673 50310574
Selective eating disorder 144.40 9.76 85 169792 1747 50433500
Off label use 140.32 9.76 975 168902 473451 49961796
Infection 137.98 9.76 230 169647 172724 50262523
Restlessness 135.29 9.76 276 169601 24897 50410350
Helicobacter infection 134.62 9.76 8 169869 49694 50385553
Generalised tonic-clonic seizure 121.25 9.76 271 169606 26039 50409208
Aggression 121.24 9.76 238 169639 20878 50414369
Pain 120.70 9.76 1303 168574 577600 49857647
Drug intolerance 120.16 9.76 358 169519 218746 50216501
Cardiac arrest 116.73 9.76 573 169304 83078 50352169
Product substitution issue 116.36 9.76 186 169691 13871 50421376
Febrile neutropenia 114.11 9.76 96 169781 97571 50337676
Therapeutic product effect decreased 114.07 9.76 175 169702 135875 50299372
Pneumonia 114.05 9.76 773 169104 377628 50057619
Drug dependence 113.80 9.76 223 169654 19536 50415711
Pyrexia 107.57 9.76 791 169086 379412 50055835
Foetal exposure during pregnancy 106.68 9.76 264 169613 27095 50408152
Arthralgia 106.15 9.76 952 168925 437750 49997497
Respiratory arrest 103.00 9.76 276 169601 29733 50405514
Gestational diabetes 102.58 9.76 126 169751 7339 50427908
Cardio-respiratory arrest 102.44 9.76 405 169472 53487 50381760
Disorientation 100.98 9.76 305 169572 35179 50400068
Peripheral swelling 98.05 9.76 358 169519 205578 50229669
Muscle injury 97.47 9.76 7 169870 37104 50398143
Psychomotor hyperactivity 95.38 9.76 136 169741 9165 50426082
Tachycardia 95.15 9.76 617 169260 99146 50336101
Drug withdrawal syndrome neonatal 94.14 9.76 65 169812 1776 50433471
Mania 93.89 9.76 147 169730 10769 50424478
Hypotonia neonatal 91.27 9.76 51 169826 946 50434301
Extrapyramidal disorder 90.99 9.76 151 169726 11619 50423628
Insomnia 89.50 9.76 939 168938 173926 50261321
Product use issue 89.48 9.76 234 169643 149241 50286006
Sepsis 89.16 9.76 196 169681 132729 50302518
Small for dates baby 88.98 9.76 82 169795 3423 50431824
Hepatic enzyme increased 88.55 9.76 207 169670 137173 50298074
Tearfulness 87.34 9.76 83 169794 3604 50431643
Abnormal dreams 87.30 9.76 131 169746 9246 50426001
Atrial septal defect 87.09 9.76 107 169770 6234 50429013
Poisoning 86.27 9.76 152 169725 12277 50422970
Mood swings 85.81 9.76 175 169702 15779 50419468
Blister 85.80 9.76 96 169781 85322 50349925
Muscle rigidity 85.43 9.76 133 169744 9696 50425551
Sleep-related eating disorder 83.42 9.76 44 169833 724 50434523
Amnesia 83.08 9.76 321 169556 41939 50393308
Stomatitis 82.42 9.76 133 169744 101211 50334036
Sleep disorder due to general medical condition, insomnia type 82.39 9.76 6 169871 31441 50403806
Nasopharyngitis 81.90 9.76 351 169526 192576 50242671
Hyperreflexia 81.26 9.76 93 169784 5025 50430222
Paraesthesia 81.16 9.76 685 169192 119558 50315689
Anaemia 80.86 9.76 506 169371 251950 50183297
Platelet count decreased 80.22 9.76 134 169743 100592 50334655
Major depression 80.12 9.76 107 169770 6777 50428470
Folliculitis 79.91 9.76 17 169860 39208 50396039
Impaired healing 77.40 9.76 72 169805 69714 50365533
C-reactive protein abnormal 76.78 9.76 4 169873 27805 50407442
Hallucination 74.90 9.76 333 169544 46324 50388923
Confusional state 74.81 9.76 953 168924 184975 50250272
Myocardial depression 73.38 9.76 34 169843 416 50434831
Antidepressant drug level increased 73.36 9.76 29 169848 232 50435015
Homicide 73.05 9.76 32 169845 340 50434907
Camptocormia 72.74 9.76 30 169847 271 50434976
Decorticate posture 72.55 9.76 30 169847 273 50434974
Stress cardiomyopathy 71.74 9.76 109 169768 7778 50427469
Mental disorder 71.22 9.76 198 169679 21793 50413454
Maternal exposure during pregnancy 70.71 9.76 286 169591 159492 50275755
Thrombocytopenia 69.63 9.76 209 169668 127464 50307783
Mental impairment 69.44 9.76 136 169741 11908 50423339
Nervousness 66.21 9.76 224 169653 27427 50407820
Migraine 65.99 9.76 456 169421 74824 50360423
Neutropenia 65.37 9.76 265 169612 147700 50287547
Thinking abnormal 65.11 9.76 116 169761 9451 50425796
Dizziness 64.40 9.76 1569 168308 344800 50090447
Disease progression 63.73 9.76 142 169735 95724 50339523
Abnormal behaviour 63.66 9.76 177 169700 19481 50415766
Antidepressant drug level above therapeutic 62.65 9.76 29 169848 354 50434893
Tardive dyskinesia 62.57 9.76 98 169779 7181 50428066
Self-injurious ideation 62.20 9.76 55 169822 2174 50433073
Weight increased 60.92 9.76 984 168893 200907 50234340
Foetal death 60.64 9.76 103 169774 8077 50427170
Electrocardiogram QRS complex prolonged 60.57 9.76 82 169795 5262 50429985
Mobility decreased 60.34 9.76 110 169767 79838 50355409
Galactorrhoea 59.70 9.76 68 169809 3655 50431592
Intentional product misuse 59.46 9.76 312 169565 46422 50388825
Physical assault 58.42 9.76 37 169840 871 50434376
Sinusitis 58.17 9.76 335 169542 170223 50265024
Musculoskeletal stiffness 58.08 9.76 228 169649 128253 50306994
Psychomotor retardation 57.49 9.76 64 169813 3354 50431893
Inappropriate affect 57.27 9.76 35 169842 772 50434475
Large for dates baby 56.72 9.76 29 169848 446 50434801
Dyspnoea 56.45 9.76 1404 168473 546204 49889043
Sedation 55.72 9.76 227 169650 30383 50404864
Pleurothotonus 55.19 9.76 41 169836 1260 50433987
Muscle twitching 55.05 9.76 144 169733 15287 50419960
Malignant neoplasm progression 54.81 9.76 90 169787 68034 50367213
Drug screen false positive 54.26 9.76 34 169843 785 50434462
Renal impairment 53.69 9.76 108 169769 75553 50359694
Congenital tricuspid valve incompetence 53.66 9.76 18 169859 84 50435163
Haemoglobin decreased 53.61 9.76 232 169645 126984 50308263
Respiratory depression 53.42 9.76 122 169755 11888 50423359
Neonatal hypoxia 53.39 9.76 28 169849 455 50434792
Ill-defined disorder 53.17 9.76 63 169814 54591 50380656
Loss of consciousness 52.68 9.76 559 169318 103794 50331453
Irritable bowel syndrome 52.54 9.76 57 169820 51384 50383863
Vertigo 52.12 9.76 325 169552 51507 50383740
Death 51.97 9.76 774 169103 324605 50110642
Lower respiratory tract infection 51.78 9.76 156 169721 95045 50340202
Homicidal ideation 51.54 9.76 44 169833 1658 50433589
Bipolar disorder 51.31 9.76 86 169791 6671 50428576
Hip arthroplasty 51.21 9.76 19 169858 30410 50404837
Tinnitus 50.71 9.76 208 169669 27924 50407323
Meconium in amniotic fluid 50.70 9.76 22 169855 228 50435019
Mood altered 50.58 9.76 124 169753 12649 50422598
Hallucination, visual 50.47 9.76 146 169731 16436 50418811
Altered state of consciousness 50.27 9.76 175 169702 21735 50413512
Pancytopenia 49.91 9.76 132 169745 83898 50351349
Benzodiazepine drug level increased 49.86 9.76 20 169857 167 50435080
Drug ineffective 49.73 9.76 2248 167629 817085 49618162
Bruxism 49.55 9.76 56 169821 2984 50432263
Nystagmus 49.38 9.76 76 169801 5485 50429762
Self esteem decreased 49.09 9.76 28 169849 541 50434706
Diarrhoea 48.59 9.76 1556 168321 586920 49848327
Apathy 48.16 9.76 89 169788 7459 50427788
Psychotic disorder 48.14 9.76 172 169705 21640 50413607
Libido decreased 47.94 9.76 49 169828 2327 50432920
Drug hypersensitivity 47.77 9.76 1141 168736 249869 50185378
Parkinsonism 47.52 9.76 97 169780 8750 50426497
Product residue present 47.29 9.76 60 169817 3612 50431635
Feeling of despair 46.99 9.76 45 169832 1973 50433274
Newborn persistent pulmonary hypertension 46.88 9.76 18 169859 132 50435115
Impulsive behaviour 46.84 9.76 39 169838 1419 50433828
Anaphylactic reaction 46.75 9.76 68 169809 53987 50381260
Cardiogenic shock 46.19 9.76 136 169741 15463 50419784
Hostility 45.84 9.76 42 169835 1740 50433507
Opsoclonus myoclonus 45.83 9.76 17 169860 112 50435135
Memory impairment 45.77 9.76 437 169440 78923 50356324
Accommodation disorder 45.67 9.76 23 169854 342 50434905
Myoclonus 45.59 9.76 129 169748 14341 50420906
Hallucination, auditory 45.55 9.76 107 169770 10621 50424626
Personality disorder 45.48 9.76 64 169813 4260 50430987
Bezoar 45.28 9.76 37 169840 1311 50433936
Suicidal behaviour 45.04 9.76 47 169830 2287 50432960
Coma scale abnormal 44.91 9.76 67 169810 4704 50430543
Somnambulism 44.71 9.76 68 169809 4856 50430391
Urinary incontinence 44.26 9.76 200 169677 28008 50407239
Neuroleptic malignant syndrome 44.02 9.76 108 169769 11022 50424225
Atrial fibrillation 43.19 9.76 185 169692 101560 50333687
Neovascularisation 43.14 9.76 32 169845 981 50434266
Gastrointestinal haemorrhage 42.92 9.76 116 169761 73205 50362042
Paranoia 42.62 9.76 102 169775 10246 50425001
Depressive symptom 42.34 9.76 53 169824 3147 50432100
Dissociation 42.19 9.76 45 169832 2246 50433001
Hypomania 42.03 9.76 63 169814 4442 50430805
Anorgasmia 41.78 9.76 25 169852 530 50434717
Single umbilical artery 41.41 9.76 19 169858 227 50435020
Lung diffusion test abnormal 41.37 9.76 17 169860 152 50435095
Euphoric mood 41.15 9.76 59 169818 3996 50431251
Alcohol interaction 41.06 9.76 43 169834 2101 50433146
Restless legs syndrome 40.93 9.76 132 169745 15765 50419482
Emotional disorder 40.75 9.76 109 169768 11727 50423520
Transient tachypnoea of the newborn 40.67 9.76 15 169862 97 50435150
Hypothermia 39.71 9.76 109 169768 11907 50423340
Hot flush 38.95 9.76 268 169609 43901 50391346
Delusion 38.08 9.76 99 169778 10470 50424777
Anticholinergic syndrome 38.01 9.76 38 169839 1757 50433490
Persistent genital arousal disorder 37.89 9.76 18 169859 234 50435013
Sinus tachycardia 37.79 9.76 157 169720 21197 50414050
Bipolar II disorder 37.35 9.76 18 169859 242 50435005
Fluid retention 37.05 9.76 71 169806 50578 50384669
Hypersomnia 36.60 9.76 124 169753 15190 50420057
Gastrointestinal disorder 36.37 9.76 178 169699 94278 50340969
Panic reaction 36.32 9.76 52 169825 3517 50431730
Rapid eye movement sleep behaviour disorder 36.20 9.76 16 169861 174 50435073
Amniorrhexis 36.08 9.76 10 169867 20 50435227
Congenital vesicoureteric reflux 36.08 9.76 10 169867 20 50435227
Psychotic symptom 36.02 9.76 31 169846 1181 50434066
Pain in extremity 36.01 9.76 672 169205 272193 50163054
Leukopenia 35.76 9.76 112 169765 67416 50367831
Injection site pain 35.75 9.76 222 169655 110802 50324445
VACTERL syndrome 35.61 9.76 9 169868 10 50435237
Total lung capacity increased 35.61 9.76 25 169852 702 50434545
Red blood cell sedimentation rate increased 35.47 9.76 28 169849 29388 50405859
Pulmonary haemorrhage neonatal 35.44 9.76 10 169867 22 50435225
Herpes zoster 35.00 9.76 121 169756 70665 50364582
Congenital hearing disorder 34.72 9.76 9 169868 12 50435235
Blood creatinine increased 34.50 9.76 135 169742 76025 50359222
Bradycardia neonatal 34.41 9.76 26 169851 820 50434427
Ventricular septal defect 34.17 9.76 54 169823 3987 50431260
Knee arthroplasty 34.14 9.76 42 169835 35804 50399443
C-reactive protein increased 33.98 9.76 112 169765 66362 50368885
Negative thoughts 33.87 9.76 26 169851 840 50434407
Drug screen positive 33.79 9.76 49 169828 3353 50431894
Skin candida 33.62 9.76 31 169846 1295 50433952
Neonatal respiratory distress syndrome 33.60 9.76 43 169834 2611 50432636
Neonatal seizure 33.50 9.76 19 169858 363 50434884
Panic disorder 33.48 9.76 40 169837 2263 50432984
Pleural effusion 33.42 9.76 150 169727 81304 50353943
Dyskinesia 33.39 9.76 183 169694 27678 50407569
Libido increased 33.35 9.76 30 169847 1213 50434034
Renal papillary necrosis 33.21 9.76 16 169861 215 50435032
Adjustment disorder with mixed anxiety and depressed mood 33.02 9.76 12 169865 74 50435173
White blood cell count decreased 32.80 9.76 243 169634 116479 50318768
Psoriatic arthropathy 32.63 9.76 68 169809 46964 50388283
Burnout syndrome 32.49 9.76 15 169862 182 50435065
Epilepsy 32.42 9.76 151 169726 21416 50413831
Toxic epidermal necrolysis 32.27 9.76 15 169862 20977 50414270
Patent ductus arteriosus 32.24 9.76 51 169826 3769 50431478
General physical health deterioration 32.18 9.76 314 169563 142120 50293127
Brain death 31.99 9.76 43 169834 2740 50432507
Lung disorder 31.73 9.76 64 169813 44735 50390512
Vitamin K decreased 31.60 9.76 8 169869 9 50435238
Logorrhoea 31.57 9.76 39 169838 2285 50432962
Acute kidney injury 31.54 9.76 557 169320 227501 50207746
Hypoventilation neonatal 31.24 9.76 9 169868 22 50435225
Bone marrow failure 31.21 9.76 28 169849 27596 50407651
Cataplexy 31.14 9.76 27 169850 1039 50434208
Agitation neonatal 31.13 9.76 20 169857 483 50434764
Parkinsonism hyperpyrexia syndrome 30.99 9.76 13 169864 123 50435124
Erythema 30.92 9.76 328 169549 146086 50289161
Injection site erythema 30.14 9.76 139 169738 74797 50360450
Tic 29.98 9.76 28 169849 1189 50434058
Loss of libido 29.86 9.76 28 169849 1195 50434052
Respiratory tract inflammation 29.83 9.76 20 169857 520 50434727
Tonic convulsion 29.60 9.76 27 169850 1112 50434135
Tachyphrenia 29.44 9.76 28 169849 1217 50434030
Myelosuppression 29.35 9.76 5 169872 13512 50421735
Rheumatoid nodule 29.28 9.76 4 169873 12731 50422516
Postmortem blood drug level abnormal 29.24 9.76 17 169860 341 50434906
Hospitalisation 29.15 9.76 123 169754 67814 50367433
Electrocardiogram QRS complex shortened 28.71 9.76 18 169859 416 50434831
Emotional poverty 28.62 9.76 16 169861 297 50434950
Asphyxia 28.56 9.76 59 169818 5368 50429879
Neuropathy peripheral 28.36 9.76 199 169678 96558 50338689
Pruritus 28.30 9.76 730 169147 282838 50152409
Impaired driving ability 28.21 9.76 49 169828 3912 50431335
Endolymphatic hydrops 28.20 9.76 6 169871 0 50435247
Substance abuse 28.06 9.76 50 169827 4074 50431173
Cough 27.97 9.76 607 169270 240657 50194590
Oedema 27.74 9.76 131 169746 70050 50365197
Social avoidant behaviour 27.36 9.76 40 169837 2757 50432490
Endometriosis 27.20 9.76 49 169828 4026 50431221
Neonatal behavioural syndrome 27.18 9.76 9 169868 40 50435207
Orthostatic intolerance 27.03 9.76 24 169853 954 50434293
Nervous system disorder 26.94 9.76 117 169760 16106 50419141
Congenital absence of bile ducts 26.84 9.76 8 169869 23 50435224
Intentional product use issue 26.77 9.76 150 169727 76768 50358479
Drug eruption 26.59 9.76 24 169853 23582 50411665
Delirium 26.49 9.76 219 169658 37973 50397274
Reversible cerebral vasoconstriction syndrome 26.31 9.76 34 169843 2085 50433162
Hyponatraemia 26.17 9.76 461 169416 95678 50339569
Femur fracture 26.13 9.76 54 169823 37410 50397837
Middle insomnia 26.10 9.76 83 169794 9838 50425409
Bone erosion 26.10 9.76 4 169873 11683 50423564
Haemangioma congenital 26.05 9.76 17 169860 422 50434825
Abnormal weight gain 25.83 9.76 28 169849 1424 50433823
Respiratory disorder neonatal 25.82 9.76 23 169854 918 50434329
Victim of sexual abuse 25.71 9.76 18 169859 503 50434744
Psychiatric symptom 25.61 9.76 51 169826 4519 50430728
False positive investigation result 25.59 9.76 18 169859 507 50434740
Adverse drug reaction 25.57 9.76 97 169780 55125 50380122
Cardiotoxicity 25.50 9.76 66 169811 6961 50428286
Feeling jittery 25.48 9.76 89 169788 11071 50424176
Upper respiratory tract infection 25.47 9.76 124 169753 65774 50369473
Feelings of worthlessness 25.36 9.76 15 169862 311 50434936
Cold sweat 25.28 9.76 86 169791 10558 50424689
Encephalopathy neonatal 24.94 9.76 7 169870 15 50435232
Persistent depressive disorder 24.89 9.76 22 169855 869 50434378
Erythema dyschromicum perstans 24.56 9.76 9 169868 57 50435190
Frustration tolerance decreased 24.53 9.76 57 169820 5617 50429630
Malignant mediastinal neoplasm 24.43 9.76 18 169859 546 50434701
Stiff person syndrome 24.43 9.76 13 169864 218 50435029
Pyramidal tract syndrome 24.38 9.76 15 169862 335 50434912
Food craving 24.30 9.76 27 169850 1412 50433835
Antipsychotic drug level increased 24.18 9.76 40 169837 3069 50432178
Hypotonia 24.16 9.76 71 169806 8063 50427184
Ascites 23.92 9.76 53 169824 35808 50399439
Impaired work ability 23.91 9.76 100 169777 13540 50421707
Somatic symptom disorder 23.83 9.76 31 169846 1913 50433334
Obsessive thoughts 23.77 9.76 17 169860 492 50434755
Encephalopathy 23.75 9.76 194 169683 33517 50401730
Derealisation 23.74 9.76 23 169854 1023 50434224
Plasma cell myeloma 23.71 9.76 43 169834 31279 50403968
Speech disorder 23.68 9.76 202 169675 35346 50399901
Skin necrosis 23.64 9.76 4 169873 10863 50424384
Septic shock 23.62 9.76 105 169772 57070 50378177
Antisocial behaviour 23.51 9.76 14 169863 294 50434953
ECG P wave inverted 23.50 9.76 5 169872 0 50435247
Tension 23.48 9.76 37 169840 2725 50432522
Slow response to stimuli 23.37 9.76 21 169856 848 50434399
Suspected suicide 23.36 9.76 54 169823 5303 50429944
Paradoxical drug reaction 23.27 9.76 43 169834 3604 50431643
Drug use disorder 23.19 9.76 39 169838 3033 50432214
Hyperprolactinaemia 23.15 9.76 41 169836 3324 50431923
Dysarthria 23.08 9.76 209 169668 37194 50398053
Post-traumatic stress disorder 22.90 9.76 47 169830 4256 50430991
Helplessness 22.89 9.76 13 169864 249 50434998
Coma acidotic 22.76 9.76 10 169867 107 50435140
Acquired amegakaryocytic thrombocytopenia 22.73 9.76 6 169871 9 50435238
Attention deficit hyperactivity disorder 22.70 9.76 34 169843 2395 50432852
Schizophreniform disorder 22.66 9.76 9 169868 73 50435174
Eosinophilic pustular folliculitis 22.57 9.76 7 169870 24 50435223
Social anxiety disorder 22.51 9.76 15 169862 386 50434861
Hyperacusis 22.48 9.76 29 169848 1775 50433472
Depressed level of consciousness 22.44 9.76 270 169607 51683 50383564
HELLP syndrome 22.36 9.76 21 169856 898 50434349
Neonatal hypotension 22.36 9.76 10 169867 112 50435135
Metabolic syndrome 22.27 9.76 25 169852 1322 50433925
Disturbance in sexual arousal 22.25 9.76 9 169868 77 50435170
Forced expiratory volume decreased 22.22 9.76 47 169830 4347 50430900
Yawning 22.09 9.76 21 169856 912 50434335
Hypocalcaemia 21.96 9.76 35 169842 26781 50408466
Neonatal tachypnoea 21.92 9.76 8 169869 50 50435197
Palpitations 21.87 9.76 442 169435 94064 50341183
Cytomegalovirus infection 21.78 9.76 17 169860 17945 50417302
Alcoholism 21.70 9.76 27 169850 1593 50433654
Abulia 21.65 9.76 15 169862 412 50434835
Enuresis 21.64 9.76 31 169846 2098 50433149
Dependence 21.60 9.76 29 169848 1846 50433401
Consciousness fluctuating 21.48 9.76 18 169859 661 50434586
Drug level increased 21.39 9.76 124 169753 19144 50416103
Dyssomnia 21.16 9.76 7 169870 31 50435216
Unemployment 21.16 9.76 5 169872 3 50435244
Congenital pulmonary hypertension 21.15 9.76 8 169869 56 50435191
Incoherent 21.11 9.76 45 169832 4185 50431062
Oropharyngeal pain 20.89 9.76 164 169713 77637 50357610
Tongue biting 20.83 9.76 24 169853 1306 50433941
Electrocardiogram ST-T segment abnormal 20.76 9.76 12 169865 238 50435009
Tenosynovitis 20.67 9.76 5 169872 10560 50424687
Starvation ketoacidosis 20.57 9.76 8 169869 61 50435186
Bradypnoea 20.57 9.76 37 169840 3037 50432210
Therapeutic product effect incomplete 20.55 9.76 202 169675 91313 50343934
Rhinorrhoea 20.55 9.76 96 169781 51487 50383760
Blood catecholamines increased 20.46 9.76 6 169871 16 50435231
Antidepressant discontinuation syndrome 20.46 9.76 6 169871 16 50435231
Ventricular tachycardia 20.37 9.76 106 169771 15715 50419532
Phagophobia 20.32 9.76 7 169870 36 50435211
Trunk injury 20.20 9.76 6 169871 17 50435230
Torsade de pointes 20.15 9.76 86 169791 11749 50423498
Neonatal disorder 20.09 9.76 16 169861 546 50434701
Full blood count abnormal 20.08 9.76 141 169736 23247 50412000
Diverticulitis 19.79 9.76 52 169825 33130 50402117
Respiratory failure 19.75 9.76 203 169674 90978 50344269
Inappropriate antidiuretic hormone secretion 19.74 9.76 92 169785 13051 50422196
Transient psychosis 19.71 9.76 7 169870 40 50435207
Upper gastrointestinal haemorrhage 19.67 9.76 15 169862 16020 50419227
Dysphoria 19.60 9.76 47 169830 4727 50430520
Skin maceration 19.56 9.76 7 169870 41 50435206
Obstructive airways disorder 19.56 9.76 104 169773 15548 50419699
Head discomfort 19.48 9.76 81 169796 10938 50424309
Neonatal asphyxia 19.45 9.76 11 169866 209 50435038
Hyperbilirubinaemia neonatal 19.36 9.76 13 169864 339 50434908
Right ventricular failure 19.32 9.76 15 169862 15878 50419369
Clonus 19.22 9.76 43 169834 4132 50431115
Cardiac failure 19.17 9.76 163 169714 75877 50359370
Multiple sclerosis 19.06 9.76 126 169751 20367 50414880
Pneumonia aspiration 19.00 9.76 173 169704 30831 50404416
Neurodegenerative disorder 18.93 9.76 12 169865 283 50434964
Mucosal inflammation 18.92 9.76 70 169807 40072 50395175
Hepatic function abnormal 18.90 9.76 52 169825 32629 50402618
Atypical fibroxanthoma 18.80 9.76 4 169873 0 50435247
Feeling guilty 18.76 9.76 15 169862 515 50434732
Neutrophil count decreased 18.73 9.76 85 169792 45941 50389306
Soft tissue injury 18.72 9.76 24 169853 1460 50433787
Sluggishness 18.72 9.76 44 169833 4369 50430878
CYP3A4 polymorphism 18.69 9.76 8 169869 80 50435167
Drug tolerance decreased 18.59 9.76 4 169873 9156 50426091
Floppy infant 18.51 9.76 8 169869 82 50435165
Dry mouth 18.49 9.76 278 169599 55900 50379347
Anhedonia 18.43 9.76 72 169805 9452 50425795
Feeling drunk 18.39 9.76 39 169838 3614 50431633
Sleep disorder 18.29 9.76 282 169595 57001 50378246
Hyperkalaemia 18.28 9.76 91 169786 47998 50387249
Prescribed overdose 18.24 9.76 97 169780 14503 50420744
Affect lability 18.21 9.76 69 169808 8929 50426318
Congestive cardiomyopathy 18.18 9.76 50 169827 5468 50429779
Intestinal strangulation 18.10 9.76 8 169869 87 50435160
Device expulsion 18.09 9.76 44 169833 28778 50406469
Deja vu 18.04 9.76 7 169870 53 50435194
Movement disorder 17.99 9.76 111 169766 17521 50417726
Violence-related symptom 17.91 9.76 13 169864 385 50434862
Cerebral infarction 17.88 9.76 28 169849 21576 50413671
Neonatal respiratory failure 17.87 9.76 10 169867 186 50435061
Eye movement disorder 17.86 9.76 44 169833 4501 50430746
Bradyphrenia 17.61 9.76 53 169824 6099 50429148
Blood triglycerides increased 17.59 9.76 80 169797 11232 50424015
Dystonia 17.56 9.76 83 169794 11843 50423404
Tremor neonatal 17.48 9.76 8 169869 95 50435152
Foetal alcohol syndrome 17.42 9.76 5 169872 12 50435235
Cerebral vasoconstriction 17.42 9.76 19 169858 973 50434274
Joint range of motion decreased 17.30 9.76 22 169855 18490 50416757
Vasoplegia syndrome 17.28 9.76 20 169857 1094 50434153
Bundle branch block right 17.24 9.76 44 169833 4601 50430646
Fall 17.21 9.76 1326 168551 333606 50101641
Nodule 17.18 9.76 19 169858 16984 50418263
Bacteraemia 17.07 9.76 14 169863 14419 50420828
Anticonvulsant drug level above therapeutic 17.06 9.76 14 169863 499 50434748
Dropped head syndrome 17.05 9.76 8 169869 101 50435146
Drug ineffective for unapproved indication 16.95 9.76 126 169751 21155 50414092
Rhabdomyolysis 16.93 9.76 203 169674 38824 50396423
Psychiatric decompensation 16.91 9.76 21 169856 1237 50434010
Immunodeficiency 16.79 9.76 15 169862 14813 50420434
Cholestasis 16.74 9.76 144 169733 25257 50409990
Oedema peripheral 16.71 9.76 403 169474 157558 50277689
Palmar-plantar erythrodysaesthesia syndrome 16.68 9.76 26 169851 20072 50415175
Persistent left superior vena cava 16.65 9.76 6 169871 36 50435211
Depression suicidal 16.63 9.76 23 169854 1506 50433741
Sleep terror 16.60 9.76 16 169861 707 50434540
Back pain 16.59 9.76 588 169289 219442 50215805
Platelet aggregation abnormal 16.57 9.76 4 169873 3 50435244
Sciatic nerve neuropathy 16.54 9.76 11 169866 282 50434965
Cold agglutinins positive 16.51 9.76 6 169871 37 50435210
Female sexual dysfunction 16.51 9.76 6 169871 37 50435210
Pulmonary fibrosis 16.39 9.76 36 169841 24401 50410846
Cystic lymphangioma 16.38 9.76 5 169872 16 50435231
Hypnopompic hallucination 16.37 9.76 6 169871 38 50435209
Fatigue 16.35 9.76 2104 167773 705497 49729750
Neurological examination abnormal 16.35 9.76 10 169867 221 50435026
Respiratory tract infection 16.32 9.76 54 169823 31963 50403284
Facial nerve disorder 16.30 9.76 14 169863 532 50434715
Splenic infarction 16.27 9.76 23 169854 1537 50433710
Basal cell carcinoma 16.00 9.76 34 169843 23322 50411925
Hypercalcaemia 16.00 9.76 34 169843 23318 50411929
Congenital uterine anomaly 15.94 9.76 8 169869 118 50435129
Transfusion 15.92 9.76 12 169865 12893 50422354
Urinary tract infection 15.92 9.76 603 169274 223417 50211830
Concussion 15.86 9.76 59 169818 7569 50427678
Fear 15.74 9.76 93 169784 14456 50420791
Exposure during pregnancy 15.67 9.76 524 169353 120491 50314756
Tumour lysis syndrome 15.56 9.76 3 169874 7418 50427829
Loose tooth 15.56 9.76 34 169843 3216 50432031
Poor personal hygiene 15.51 9.76 11 169866 314 50434933
Akinesia 15.49 9.76 22 169855 1477 50433770
Foetal arrhythmia 15.48 9.76 8 169869 126 50435121
Ligament pain 15.46 9.76 9 169868 181 50435066
Merycism 15.42 9.76 9 169868 182 50435065
Peak expiratory flow rate decreased 15.40 9.76 14 169863 574 50434673
Nephropathy toxic 15.32 9.76 4 169873 8025 50427222
Language disorder 15.27 9.76 24 169853 1764 50433483
Acute hepatitis B 15.21 9.76 11 169866 324 50434923
Central nervous system necrosis 15.20 9.76 8 169869 131 50435116
Cytokine release syndrome 15.20 9.76 5 169872 8629 50426618
Purging 15.18 9.76 6 169871 48 50435199
Pancreatic enlargement 15.18 9.76 6 169871 48 50435199
Iodine allergy 15.14 9.76 15 169862 686 50434561
Skin ulcer 15.11 9.76 64 169813 35254 50399993
Acute myeloid leukaemia 15.06 9.76 17 169860 15057 50420190
Persecutory delusion 15.05 9.76 28 169849 2359 50432888
Slow speech 15.03 9.76 20 169857 1262 50433985
Abnormal sleep-related event 15.01 9.76 15 169862 693 50434554
Flight of ideas 15.01 9.76 11 169866 331 50434916
Lung diffusion test decreased 14.98 9.76 14 169863 595 50434652
Blood lactic acid increased 14.95 9.76 47 169830 5538 50429709
Enthesopathy 14.89 9.76 3 169874 7190 50428057
Pneumonitis 14.88 9.76 50 169827 29460 50405787
Sleep talking 14.84 9.76 17 169860 919 50434328
Osteoporosis 14.82 9.76 89 169788 44790 50390457
Kleptomania 14.79 9.76 5 169872 24 50435223
Cellulitis 14.77 9.76 159 169718 70639 50364608
Creatinine renal clearance decreased 14.72 9.76 11 169866 11870 50423377
Stress 14.65 9.76 258 169619 53535 50381712
Alcohol use 14.63 9.76 25 169852 1970 50433277
Right ventricular systolic pressure decreased 14.63 9.76 5 169872 25 50435222
Labour complication 14.60 9.76 7 169870 93 50435154
Bladder trabeculation 14.57 9.76 6 169871 54 50435193
Apallic syndrome 14.52 9.76 14 169863 619 50434628
Retinal detachment 14.50 9.76 44 169833 5085 50430162
Hypokinesia 14.47 9.76 80 169797 12137 50423110
Conversion disorder 14.43 9.76 22 169855 1574 50433673
Increased appetite 14.42 9.76 61 169816 8300 50426947
Cholestatic liver injury 14.39 9.76 25 169852 1996 50433251
Neurotoxicity 14.32 9.76 17 169860 14723 50420524
Epstein-Barr virus infection 14.32 9.76 3 169874 6994 50428253
Neoplasm progression 14.30 9.76 50 169827 29107 50406140
Brief psychotic disorder with marked stressors 14.10 9.76 6 169871 59 50435188
Post-traumatic neck syndrome 14.09 9.76 24 169853 1886 50433361
Infantile apnoea 14.09 9.76 16 169861 857 50434390
Pre-existing condition improved 14.01 9.76 54 169823 7043 50428204
Cogwheel rigidity 14.01 9.76 23 169854 1754 50433493
Perinatal depression 14.00 9.76 13 169864 548 50434699
Nonspecific reaction 13.99 9.76 23 169854 1756 50433491
Ideas of reference 13.97 9.76 7 169870 103 50435144
Thrombosis 13.93 9.76 120 169757 55713 50379534
Cytopenia 13.91 9.76 6 169871 8769 50426478
Liver function test increased 13.88 9.76 42 169835 25564 50409683
Vision blurred 13.87 9.76 354 169523 78293 50356954
Bipolar I disorder 13.84 9.76 21 169856 1497 50433750
Live birth 13.83 9.76 21 169856 16387 50418860
Marital problem 13.83 9.76 8 169869 159 50435088
Death neonatal 13.80 9.76 9 169868 223 50435024
Anaemia of pregnancy 13.76 9.76 6 169871 63 50435184
Respiration abnormal 13.71 9.76 43 169834 5059 50430188
Anal atresia 13.70 9.76 11 169866 380 50434867
Postmortem blood drug level increased 13.59 9.76 13 169864 569 50434678
Mechanical urticaria 13.55 9.76 11 169866 386 50434861
Arthritis 13.55 9.76 207 169670 86514 50348733
Narcolepsy 13.45 9.76 18 169859 1142 50434105
Haematocrit decreased 13.40 9.76 66 169811 34910 50400337
Cardiomyopathy 13.40 9.76 94 169783 15492 50419755
Injection site rash 13.36 9.76 21 169856 16156 50419091
Skin disorder 13.33 9.76 39 169838 23991 50411256
Pulmonary artery stenosis congenital 13.32 9.76 9 169868 237 50435010
Jaundice neonatal 13.32 9.76 15 169862 796 50434451
Proteinuria 13.28 9.76 22 169855 16575 50418672
Sternal fracture 13.27 9.76 24 169853 1978 50433269
Osteonecrosis of jaw 13.27 9.76 60 169817 32466 50402781
Haemangioma 13.09 9.76 27 169850 2453 50432794
Divorced 13.06 9.76 4 169873 13 50435234
Exposure via ingestion 13.05 9.76 29 169848 2774 50432473
Sleep apnoea syndrome 13.05 9.76 130 169747 23738 50411509
Ventricular hypokinesia 13.05 9.76 36 169841 3944 50431303
Barotrauma 12.99 9.76 8 169869 179 50435068
Tympanic membrane disorder 12.99 9.76 8 169869 179 50435068
Formication 12.98 9.76 34 169843 3612 50431635
Colitis 12.94 9.76 76 169801 38453 50396794
Hereditary non-polyposis colorectal cancer syndrome 12.91 9.76 7 169870 122 50435125
Anuria 12.90 9.76 73 169804 11171 50424076
Distributive shock 12.89 9.76 15 169862 825 50434422
Drug abuser 12.88 9.76 29 169848 2799 50432448
Muscle tone disorder 12.81 9.76 7 169870 124 50435123
Ocular hyperaemia 12.72 9.76 31 169846 20261 50414986
Dialysis 12.67 9.76 8 169869 9430 50425817
Cardiac failure congestive 12.65 9.76 203 169674 84179 50351068
Injection site bruising 12.63 9.76 72 169805 36696 50398551
Substance use 12.59 9.76 10 169867 340 50434907
Neuropsychiatric syndrome 12.54 9.76 5 169872 41 50435206
Radius fracture 12.54 9.76 31 169846 3178 50432069
Cerebral haematoma 12.53 9.76 31 169846 3180 50432067
Parkinsonian gait 12.52 9.76 11 169866 431 50434816
Metastases to bone 12.49 9.76 26 169851 17969 50417278
Brain contusion 12.46 9.76 12 169865 530 50434717
Skin discolouration 12.44 9.76 62 169815 32695 50402552
Thrombotic microangiopathy 12.44 9.76 7 169870 8784 50426463
Focal dyscognitive seizures 12.42 9.76 28 169849 2704 50432543
Affective disorder 12.42 9.76 42 169835 5139 50430108
Drug level above therapeutic 12.40 9.76 35 169842 3885 50431362
Arachnoid cyst 12.39 9.76 8 169869 195 50435052
Accidental exposure to product 12.37 9.76 38 169839 23019 50412228
Febrile bone marrow aplasia 12.32 9.76 3 169874 6308 50428939
Rash pruritic 12.31 9.76 102 169775 47744 50387503
Urticaria 12.25 9.76 336 169541 129225 50306022
Second primary malignancy 12.18 9.76 4 169873 6910 50428337
Activation syndrome 12.17 9.76 8 169869 201 50435046
Myelodysplastic syndrome 12.16 9.76 20 169857 15112 50420135
Bladder dilatation 12.12 9.76 14 169863 764 50434483
Hypertonia 12.11 9.76 35 169842 3938 50431309
Interstitial lung disease 12.09 9.76 117 169760 53059 50382188
Obsessive rumination 12.03 9.76 3 169874 3 50435244
Antidepressant drug level decreased 12.03 9.76 3 169874 3 50435244
Anxiety disorder due to a general medical condition 12.03 9.76 3 169874 3 50435244
CYP2D6 polymorphism 12.03 9.76 3 169874 3 50435244
Premature delivery 12.00 9.76 40 169837 23623 50411624
Device related infection 11.98 9.76 33 169844 20702 50414545
Blood bilirubin increased 11.96 9.76 61 169816 31977 50403270
Emotional distress 11.95 9.76 148 169729 28515 50406732
No adverse event 11.94 9.76 65 169812 33513 50401734
Foetal growth restriction 11.94 9.76 49 169828 6578 50428669
Melaena 11.92 9.76 48 169829 26816 50408431
Wheezing 11.90 9.76 142 169735 61905 50373342
Decreased interest 11.90 9.76 29 169848 2947 50432300
Coarctation of the aorta 11.89 9.76 12 169865 561 50434686
Blood urea increased 11.87 9.76 40 169837 23545 50411702
Renal failure 11.84 9.76 270 169607 106363 50328884
Electroencephalogram abnormal 11.82 9.76 32 169845 3467 50431780
Ocular hypertension 11.80 9.76 14 169863 786 50434461
Transplant rejection 11.77 9.76 9 169868 9600 50425647
Ataxia 11.77 9.76 83 169794 13703 50421544
Arrhythmia 11.71 9.76 166 169711 32966 50402281
Exposure via transplant 11.70 9.76 4 169873 20 50435227
Hypervolaemia 11.67 9.76 45 169832 25454 50409793
Blood immunoglobulin E increased 11.66 9.76 25 169852 2334 50432913
Cataract 11.65 9.76 102 169775 47198 50388049
Housebound 11.60 9.76 8 169869 218 50435029
Polydactyly 11.43 9.76 9 169868 302 50434945
Parachute mitral valve 11.41 9.76 6 169871 98 50435149
Tubulointerstitial nephritis 11.41 9.76 21 169856 15190 50420057
Adverse event 11.40 9.76 93 169784 43670 50391577
Coordination abnormal 11.39 9.76 72 169805 11462 50423785
Parasomnia 11.38 9.76 10 169867 392 50434855
Xanthopsia 11.35 9.76 7 169870 157 50435090
Drug withdrawal convulsions 11.33 9.76 18 169859 1335 50433912
COVID-19 11.33 9.76 101 169776 46561 50388686
Intestinal anastomosis complication 11.23 9.76 8 169869 230 50435017
Respiratory acidosis 11.20 9.76 45 169832 5983 50429264
Cardiac valve disease 11.20 9.76 33 169844 3753 50431494
Respiratory tract congestion 11.19 9.76 19 169858 14180 50421067
Personality change 11.19 9.76 43 169834 5602 50429645
Pre-eclampsia 11.13 9.76 55 169822 7989 50427258
Dyspnoea exertional 11.12 9.76 114 169763 51119 50384128
Morbihan disease 11.10 9.76 4 169873 24 50435223
Aplastic anaemia 11.09 9.76 6 169871 7697 50427550
Cognitive disorder 11.09 9.76 209 169668 43914 50391333
Respiratory rate decreased 11.08 9.76 29 169848 3079 50432168
Peritonitis 11.07 9.76 22 169855 15464 50419783
Hypertonia neonatal 11.05 9.76 8 169869 236 50435011
Ulcer 11.05 9.76 33 169844 20167 50415080
Pulmonary vein occlusion 11.05 9.76 6 169871 105 50435142
Ultrasound abdomen abnormal 11.03 9.76 5 169872 58 50435189
Haemolytic anaemia 11.01 9.76 9 169868 9283 50425964
Feeling of body temperature change 11.00 9.76 36 169841 4331 50430916
Breech presentation 11.00 9.76 16 169861 1098 50434149
Drug specific antibody 11.00 9.76 21 169856 1804 50433443
Therapeutic response unexpected 10.89 9.76 91 169786 15824 50419423
Rhythm idioventricular 10.86 9.76 7 169870 170 50435077
Congenital pharyngeal anomaly 10.83 9.76 3 169874 6 50435241
Crush injury 10.83 9.76 3 169874 6 50435241
Mixed anxiety and depressive disorder 10.82 9.76 7 169870 171 50435076
Bronchopulmonary aspergillosis 10.81 9.76 6 169871 7586 50427661
Wrong patient received product 10.79 9.76 20 169857 1680 50433567
Pain in jaw 10.78 9.76 80 169797 38348 50396899
Platelet aggregation decreased 10.70 9.76 4 169873 27 50435220
Dissociative amnesia 10.70 9.76 4 169873 27 50435220
Trismus 10.69 9.76 30 169847 3318 50431929
Haemophagocytic lymphohistiocytosis 10.68 9.76 8 169869 8625 50426622
Tongue discomfort 10.65 9.76 21 169856 1847 50433400
Hyperemesis gravidarum 10.60 9.76 11 169866 532 50434715
Injection site reaction 10.58 9.76 112 169765 49920 50385327
Product formulation issue 10.56 9.76 11 169866 534 50434713
Pathogen resistance 10.55 9.76 3 169874 5686 50429561
Congenital naevus 10.54 9.76 7 169870 179 50435068
Pleural disorder 10.51 9.76 11 169866 537 50434710
Throat irritation 10.50 9.76 59 169818 30180 50405067
Blood calcium decreased 10.50 9.76 35 169842 20671 50414576
Therapy non-responder 10.48 9.76 115 169762 50907 50384340
Injection site pruritus 10.47 9.76 86 169791 40325 50394922
Status epilepticus 10.46 9.76 79 169798 13327 50421920
Dreamy state 10.46 9.76 4 169873 29 50435218
Impatience 10.41 9.76 9 169868 345 50434902
Localised infection 10.40 9.76 47 169830 25438 50409809
Agoraphobia 10.35 9.76 9 169868 348 50434899
Hypersexuality 10.34 9.76 10 169867 444 50434803
Pneumonia viral 10.33 9.76 5 169872 6829 50428418
Unresponsive to stimuli 10.28 9.76 152 169725 30457 50404790
Multiple allergies 10.27 9.76 8 169869 8455 50426792
Balance disorder 10.27 9.76 310 169567 70280 50364967
Intellectual disability 10.27 9.76 13 169864 781 50434466
Foetal heart rate deceleration abnormality 10.21 9.76 10 169867 451 50434796
Urosepsis 10.19 9.76 23 169854 15442 50419805
Staring 10.19 9.76 18 169859 1456 50433791
Prescription form tampering 10.19 9.76 11 169866 557 50434690
Polycythaemia 10.18 9.76 13 169864 788 50434459
Hypoglycaemic seizure 10.13 9.76 10 169867 455 50434792
Communication disorder 10.09 9.76 23 169854 2238 50433009
Musculoskeletal pain 10.05 9.76 176 169701 72001 50363246
Cartilage injury 10.03 9.76 19 169858 1623 50433624
Hypnagogic hallucination 9.99 9.76 6 169871 128 50435119
Hypoalbuminaemia 9.98 9.76 11 169866 9849 50425398
Subacute kidney injury 9.97 9.76 3 169874 9 50435238
Device issue 9.96 9.76 34 169843 19938 50415309
Glassy eyes 9.95 9.76 5 169872 74 50435173
Systemic infection 9.94 9.76 23 169854 2260 50432987
Hereditary ataxia 9.91 9.76 4 169873 34 50435213
Hyperchloraemia 9.90 9.76 12 169865 689 50434558
Attention-seeking behaviour 9.89 9.76 5 169872 75 50435172
Neurodermatitis 9.89 9.76 15 169862 1069 50434178
Bronchospasm 9.86 9.76 22 169855 14832 50420415
Atrial tachycardia 9.86 9.76 22 169855 2110 50433137
Unintentional medical device removal 9.83 9.76 3 169874 5432 50429815
Tanning 9.77 9.76 5 169872 77 50435170
Gastric banding 9.77 9.76 5 169872 77 50435170
Pseudophaeochromocytoma 9.77 9.76 5 169872 77 50435170
Obsessive-compulsive disorder 9.77 9.76 29 169848 3311 50431936
Pulmonary oedema 9.77 9.76 111 169766 48827 50386420

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 749.10 10.89 994 69298 89252 29414983
Serotonin syndrome 741.57 10.89 482 69810 17030 29487205
Drug withdrawal syndrome 452.71 10.89 361 69931 17623 29486612
Suicide attempt 420.61 10.89 460 69832 33650 29470585
Intentional overdose 416.18 10.89 485 69807 38043 29466192
Suicidal ideation 412.22 10.89 459 69833 34257 29469978
Toxicity to various agents 392.40 10.89 1098 69194 172563 29331672
Overdose 266.87 10.89 587 69705 79232 29425003
Withdrawal syndrome 219.28 10.89 193 70099 10799 29493436
Foetal exposure during pregnancy 176.84 10.89 301 69991 33566 29470669
Anxiety 160.88 10.89 507 69785 84858 29419377
Coma 157.20 10.89 312 69980 39138 29465097
Hyperhidrosis 154.92 10.89 418 69874 64122 29440113
Agitation 153.16 10.89 361 69931 50943 29453292
Maternal exposure during pregnancy 149.16 10.89 103 70189 4020 29500215
Mania 149.05 10.89 140 70152 8523 29495712
Drug withdrawal syndrome neonatal 147.38 10.89 95 70197 3300 29500935
Febrile neutropenia 143.83 10.89 44 70248 112196 29392039
Depression 137.48 10.89 480 69812 84667 29419568
Pneumonia 134.95 10.89 357 69935 319815 29184420
Drug abuse 133.91 10.89 456 69836 79427 29424808
Disturbance in attention 133.00 10.89 206 70086 21218 29483017
Mydriasis 127.71 10.89 110 70182 5975 29498260
Drug interaction 122.38 10.89 845 69447 196540 29307695
Exposure during pregnancy 120.62 10.89 124 70168 8430 29495805
Sopor 118.49 10.89 138 70154 10796 29493439
Poisoning deliberate 117.04 10.89 102 70190 5629 29498606
Pyrexia 114.17 10.89 330 69962 287292 29216943
Intentional self-injury 111.86 10.89 143 70149 12318 29491917
Anaemia 111.23 10.89 192 70100 200759 29303476
Respiratory disorder neonatal 110.16 10.89 58 70234 1367 29502868
Selective eating disorder 107.17 10.89 60 70232 1603 29502632
Tremor 104.66 10.89 398 69894 73140 29431095
Small for dates baby 101.17 10.89 77 70215 3502 29500733
Restlessness 100.30 10.89 185 70107 21960 29482275
Hypotonia neonatal 100.26 10.89 52 70240 1187 29503048
Somnolence 98.32 10.89 463 69829 93492 29410743
Bipolar disorder 93.38 10.89 71 70221 3224 29501011
Nightmare 93.14 10.89 125 70167 11292 29492943
Neonatal respiratory distress syndrome 90.54 10.89 74 70218 3736 29500499
Irritability 89.16 10.89 176 70116 21976 29482259
Hyperreflexia 88.12 10.89 64 70228 2708 29501527
Sepsis 87.71 10.89 127 70165 142555 29361680
Drug dependence 86.02 10.89 168 70124 20813 29483422
Depressed mood 85.55 10.89 146 70146 16302 29487933
Seizure 83.31 10.89 439 69853 92684 29411551
Myoclonus 82.62 10.89 128 70164 13181 29491054
Sedation 82.11 10.89 148 70144 17257 29486978
Cataplexy 81.95 10.89 29 70263 243 29503992
Poisoning 79.37 10.89 108 70184 9885 29494350
Psychotic symptom 77.73 10.89 46 70246 1368 29502867
Dyspnoea 77.47 10.89 458 69834 326274 29177961
Neutropenia 77.29 10.89 121 70171 131590 29372645
Rash 76.46 10.89 216 70076 189603 29314632
Major depression 75.79 10.89 67 70225 3768 29500467
Electrocardiogram QT prolonged 74.84 10.89 222 70070 35915 29468320
Acute kidney injury 73.29 10.89 353 69939 264914 29239321
Erectile dysfunction 72.37 10.89 143 70149 17866 29486369
Aggression 72.33 10.89 217 70075 35324 29468911
Dyskinesia 71.98 10.89 152 70140 19909 29484326
Diarrhoea 71.33 10.89 481 69811 332217 29172018
Bradycardia neonatal 66.31 10.89 36 70256 904 29503331
Agitation neonatal 65.07 10.89 37 70255 1019 29503216
Off label use 63.87 10.89 436 69856 300364 29203871
Disease progression 63.03 10.89 61 70231 81855 29422380
Talipes 63.02 10.89 44 70248 1748 29502487
Delusion 61.57 10.89 102 70190 11114 29493121
Hypertonia 60.40 10.89 59 70233 3770 29500465
Interstitial lung disease 60.16 10.89 31 70261 57687 29446548
Psychotic disorder 59.35 10.89 142 70150 20212 29484023
Hallucination, auditory 59.18 10.89 92 70200 9501 29494734
Insomnia 58.38 10.89 386 69906 88375 29415860
Malignant neoplasm progression 57.99 10.89 54 70238 73805 29430430
Hypertonia neonatal 57.69 10.89 25 70267 375 29503860
Infantile apnoea 57.22 10.89 32 70260 853 29503382
Anger 57.07 10.89 97 70195 10793 29493442
Postmortem blood drug level increased 56.08 10.89 21 70271 210 29504025
Platelet count decreased 55.99 10.89 102 70190 104570 29399665
Homicide 55.80 10.89 32 70260 896 29503339
Altered state of consciousness 55.05 10.89 136 70156 19753 29484482
Hallucination, visual 54.13 10.89 114 70178 14901 29489334
Somnambulism 53.54 10.89 48 70244 2750 29501485
Miosis 52.49 10.89 79 70213 7930 29496305
Atrial septal defect 51.84 10.89 72 70220 6717 29497518
Cough 51.11 10.89 144 70148 126583 29377652
Congenital megaureter 50.81 10.89 17 70275 118 29504117
Antipsychotic drug level above therapeutic 50.74 10.89 32 70260 1069 29503166
Thrombocytopenia 49.50 10.89 160 70132 134663 29369572
Pruritus 48.44 10.89 131 70161 116718 29387517
Stress cardiomyopathy 48.25 10.89 36 70256 1588 29502647
Parkinsonism 48.00 10.89 72 70220 7206 29497029
Sexual dysfunction 47.94 10.89 64 70228 5750 29498485
Renal impairment 47.40 10.89 75 70217 81258 29422977
Death 47.39 10.89 553 69739 341531 29162704
Neonatal tachypnoea 46.69 10.89 17 70275 156 29504079
Drug screen positive 46.32 10.89 51 70241 3750 29500485
Feelings of worthlessness 46.22 10.89 19 70273 248 29503987
Haemoglobin decreased 46.06 10.89 120 70172 108255 29395980
Confusional state 45.83 10.89 485 69807 127392 29376843
Neuropathy peripheral 45.80 10.89 61 70231 70966 29433269
Infection 45.46 10.89 70 70222 76681 29427554
Septic shock 45.37 10.89 49 70243 62511 29441724
Akathisia 44.89 10.89 67 70225 6675 29497560
Intentional product misuse 44.71 10.89 182 70110 34479 29469756
Feeling jittery 44.71 10.89 49 70243 3584 29500651
Impulsive behaviour 44.62 10.89 37 70255 1906 29502329
Respiratory failure 44.04 10.89 104 70188 97027 29407208
Cytomegalovirus infection 43.46 10.89 3 70289 23212 29481023
Hypomania 42.98 10.89 38 70254 2137 29502098
Antidepressant drug level increased 42.50 10.89 14 70278 92 29504143
Cardiac failure congestive 42.41 10.89 73 70219 76508 29427727
Clonus 41.99 10.89 39 70253 2339 29501896
Psychomotor hyperactivity 41.52 10.89 72 70220 8141 29496094
Tachycardia 41.18 10.89 304 69988 72106 29432129
Feeling abnormal 40.89 10.89 245 70047 54200 29450035
Panic attack 40.80 10.89 72 70220 8254 29495981
Maternal drugs affecting foetus 40.29 10.89 48 70244 3845 29500390
Pancytopenia 40.19 10.89 86 70206 83082 29421153
Erythema 40.12 10.89 74 70218 75532 29428703
Gastrointestinal haemorrhage 39.47 10.89 81 70211 79452 29424783
Abnormal behaviour 38.65 10.89 132 70160 22995 29481240
Bone marrow failure 38.44 10.89 9 70283 27440 29476795
Memory impairment 38.27 10.89 180 70112 36290 29467945
Restless legs syndrome 37.64 10.89 63 70229 6921 29497314
Rheumatoid arthritis 37.02 10.89 15 70277 32137 29472098
Electrocardiogram QRS complex prolonged 36.61 10.89 47 70245 4063 29500172
Neuroleptic malignant syndrome 36.11 10.89 102 70190 16046 29488189
Stomatitis 35.69 10.89 22 70270 37091 29467144
Blood creatinine increased 34.81 10.89 96 70196 85006 29419229
Social anxiety disorder 34.67 10.89 15 70277 224 29504011
Sleep disorder 34.64 10.89 132 70160 24254 29479981
Self-injurious ideation 34.51 10.89 29 70263 1522 29502713
Pleural effusion 34.20 10.89 75 70217 71833 29432402
Hepatic function abnormal 34.12 10.89 26 70266 39233 29465002
Urinary retention 33.88 10.89 158 70134 31740 29472495
Product substitution issue 33.48 10.89 70 70222 9102 29495133
Muscle rigidity 33.39 10.89 71 70221 9340 29494895
Tardive dyskinesia 33.23 10.89 51 70241 5207 29499028
Neonatal toxicity 32.99 10.89 9 70283 27 29504208
Atrial fibrillation 32.42 10.89 135 70157 105511 29398724
Poor weight gain neonatal 32.30 10.89 8 70284 14 29504221
Poor quality sleep 32.20 10.89 60 70232 7173 29497062
Paranoia 32.18 10.89 72 70220 9805 29494430
Macrophages increased 32.17 10.89 13 70279 162 29504073
Cardio-respiratory arrest 31.40 10.89 217 70075 50384 29453851
Suicidal behaviour 31.36 10.89 26 70266 1339 29502896
Tremor neonatal 31.30 10.89 16 70276 354 29503881
Neonatal disorder 31.27 10.89 21 70271 782 29503453
Hyperthermia 31.02 10.89 69 70223 9361 29494874
Extrapyramidal disorder 30.96 10.89 75 70217 10756 29493479
Oedema peripheral 30.75 10.89 134 70158 103423 29400812
Encephalopathy neonatal 30.24 10.89 9 70283 40 29504195
Arthralgia 30.19 10.89 201 70091 139416 29364819
Logorrhoea 30.16 10.89 32 70260 2256 29501979
Apgar score low 29.99 10.89 21 70271 838 29503397
Obsessive-compulsive disorder 29.79 10.89 45 70247 4531 29499704
International normalised ratio increased 29.74 10.89 37 70255 44335 29459900
Alcoholism 29.52 10.89 34 70258 2627 29501608
Homicidal ideation 29.27 10.89 33 70259 2491 29501744
Normal pressure hydrocephalus 29.17 10.89 12 70280 157 29504078
Libido decreased 29.03 10.89 43 70249 4255 29499980
Electric shock 29.03 10.89 11 70281 114 29504121
Muscle twitching 29.00 10.89 61 70231 7965 29496270
Infusion related reaction 28.99 10.89 37 70255 43849 29460386
Dysphoria 28.90 10.89 30 70262 2062 29502173
Stevens-Johnson syndrome 28.51 10.89 3 70289 16494 29487741
Sleep apnoea syndrome 28.14 10.89 99 70193 17500 29486735
Chronic kidney disease 28.13 10.89 27 70265 36389 29467846
Implant site extravasation 27.62 10.89 15 70277 377 29503858
Thermophobia 27.34 10.89 9 70283 59 29504176
Tearfulness 27.29 10.89 26 70266 1610 29502625
Apathy 27.23 10.89 51 70241 6120 29498115
Epilepsy 27.20 10.89 101 70191 18331 29485904
Disseminated intravascular coagulation 27.10 10.89 7 70285 19973 29484262
Cognitive disorder 26.89 10.89 119 70173 23380 29480855
Multiple organ dysfunction syndrome 26.70 10.89 70 70222 63046 29441189
Abnormal dreams 26.65 10.89 54 70238 6866 29497369
Premature baby 26.60 10.89 96 70196 17184 29487051
White blood cell count decreased 26.52 10.89 105 70187 83257 29420978
Mood altered 26.29 10.89 59 70233 8052 29496183
Dry mouth 26.22 10.89 112 70180 21672 29482563
Weight increased 26.13 10.89 288 70004 76379 29427856
Acoustic stimulation tests abnormal 26.13 10.89 9 70283 69 29504166
Depression suicidal 26.03 10.89 23 70269 1292 29502943
Multiple drug therapy 25.73 10.89 14 70278 353 29503882
Ejaculation disorder 25.55 10.89 20 70272 948 29503287
Eosinophilic myocarditis 25.53 10.89 15 70277 440 29503795
Wrong dose 25.32 10.89 15 70277 447 29503788
Euphoric mood 25.31 10.89 43 70249 4782 29499453
Thinking abnormal 25.29 10.89 45 70247 5191 29499044
Neonatal testicular torsion 25.22 10.89 5 70287 0 29504235
Potentiating drug interaction 25.22 10.89 41 70251 4397 29499838
Joint swelling 25.08 10.89 50 70242 49580 29454655
Mucosal inflammation 24.90 10.89 23 70269 31572 29472663
Decreased interest 24.87 10.89 28 70264 2110 29502125
Liver disorder 24.60 10.89 18 70274 27731 29476504
Pneumocystis jirovecii pneumonia 24.51 10.89 5 70287 16774 29487461
Acute myocardial infarction 24.30 10.89 49 70243 48389 29455846
Pyramidal tract syndrome 24.14 10.89 11 70281 187 29504048
Foetal malnutrition 23.98 10.89 8 70284 55 29504180
Fall 23.83 10.89 570 69722 176608 29327627
Mental impairment 23.71 10.89 61 70231 9080 29495155
Neonatal respiratory failure 23.68 10.89 13 70279 334 29503901
Arachnoid cyst 23.67 10.89 11 70281 196 29504039
Disorientation 23.56 10.89 135 70157 29380 29474855
Priapism 23.54 10.89 40 70252 4448 29499787
Inappropriate antidiuretic hormone secretion 23.42 10.89 68 70224 10864 29493371
Cardiac failure 23.28 10.89 103 70189 79184 29425051
Cerebral infarction 23.21 10.89 15 70277 24660 29479575
Renal failure 23.07 10.89 176 70116 118423 29385812
Anaphylactic reaction 23.03 10.89 19 70273 27554 29476681
Salivary hypersecretion 23.02 10.89 53 70239 7356 29496879
Loss of consciousness 22.90 10.89 273 70019 73783 29430452
Dissociation 22.86 10.89 20 70272 1109 29503126
Pressure of speech 22.85 10.89 14 70278 444 29503791
Mood swings 22.67 10.89 52 70240 7199 29497036
Renal aplasia 22.60 10.89 16 70276 650 29503585
Product residue present 22.56 10.89 29 70263 2510 29501725
Head circumference abnormal 22.53 10.89 7 70285 37 29504198
Amnesia 22.48 10.89 110 70182 22533 29481702
Muscle mass 22.39 10.89 11 70281 223 29504012
Pulmonary contusion 22.38 10.89 7 70285 38 29504197
Depersonalisation/derealisation disorder 22.16 10.89 15 70277 566 29503669
Phaeochromocytoma malignant 22.11 10.89 8 70284 72 29504163
Drug hypersensitivity 21.96 10.89 254 70038 68152 29436083
Generalised tonic-clonic seizure 21.96 10.89 97 70195 19042 29485193
Blood ethanol increased 21.95 10.89 14 70278 477 29503758
Toxic cardiomyopathy 21.82 10.89 11 70281 236 29503999
Plasma cell myeloma 21.82 10.89 34 70258 37081 29467154
Alopecia 21.81 10.89 9 70283 19075 29485160
Blood cholesterol increased 21.80 10.89 84 70208 15511 29488724
Iris coloboma 21.75 10.89 6 70286 19 29504216
External auditory canal atresia 21.74 10.89 10 70282 174 29504061
Kidney duplex 21.72 10.89 13 70279 395 29503840
Retinal coloboma 21.52 10.89 6 70286 20 29504215
Splenomegaly 21.51 10.89 3 70289 13276 29490959
Persecutory delusion 21.50 10.89 26 70266 2115 29502120
Testicular atrophy 21.29 10.89 14 70278 503 29503732
Neonatal respiratory distress 21.27 10.89 14 70278 504 29503731
Hangover 21.19 10.89 18 70274 959 29503276
COVID-19 21.16 10.89 33 70259 35981 29468254
Ascites 21.10 10.89 34 70258 36585 29467650
Hypervigilance 21.07 10.89 9 70283 130 29504105
Paraesthesia 21.05 10.89 208 70084 53637 29450598
Blood bilirubin increased 20.94 10.89 30 70262 33863 29470372
Coagulation disorder neonatal 20.67 10.89 6 70286 24 29504211
Histamine level increased 20.51 10.89 7 70285 52 29504183
Electrocardiogram QT shortened 20.47 10.89 9 70283 140 29504095
Loose associations 20.17 10.89 7 70285 55 29504180
Forearm fracture 20.17 10.89 7 70285 55 29504180
Metabolic syndrome 20.12 10.89 21 70271 1452 29502783
External ear disorder 20.10 10.89 6 70286 27 29504208
Foetal hypokinesia 20.00 10.89 12 70280 366 29503869
Persistent depressive disorder 19.95 10.89 11 70281 285 29503950
Myocardial fibrosis 19.80 10.89 18 70274 1050 29503185
Gun shot wound 19.56 10.89 18 70274 1067 29503168
Hepatocellular injury 19.54 10.89 101 70191 21142 29483093
Foaming at mouth 19.41 10.89 15 70277 698 29503537
Myelodysplastic syndrome 19.37 10.89 9 70283 17785 29486450
Affective disorder 19.30 10.89 30 70262 3096 29501139
Pneumonitis 19.20 10.89 23 70269 28021 29476214
Poor sucking reflex 19.18 10.89 11 70281 308 29503927
Rhabdomyolysis 19.17 10.89 225 70067 60583 29443652
Penoscrotal fusion 19.13 10.89 5 70287 12 29504223
Violence-related symptom 19.13 10.89 13 70279 494 29503741
Abulia 19.03 10.89 13 70279 498 29503737
Personality disorder 19.03 10.89 18 70274 1105 29503130
Bruxism 18.83 10.89 21 70271 1566 29502669
Hypospadias 18.80 10.89 29 70263 2973 29501262
Loss of libido 18.51 10.89 25 70267 2271 29501964
Neonatal behavioural syndrome 18.46 10.89 8 70284 120 29504115
Gastrointestinal hypermotility 18.40 10.89 8 70284 121 29504114
Micturition urgency 18.32 10.89 39 70253 5134 29499101
Visual evoked potentials abnormal 18.26 10.89 7 70285 75 29504160
Haematoma 18.17 10.89 17 70275 23195 29481040
Congenital central nervous system anomaly 17.96 10.89 12 70280 443 29503792
Dyskinesia neonatal 17.95 10.89 4 70288 3 29504232
Patent ductus arteriosus 17.89 10.89 29 70263 3102 29501133
Drug screen false positive 17.84 10.89 14 70278 666 29503569
Rebound effect 17.74 10.89 23 70269 2008 29502227
Lymphadenopathy 17.73 10.89 20 70272 25029 29479206
Sleep-related eating disorder 17.57 10.89 10 70282 276 29503959
Depressive symptom 17.49 10.89 21 70271 1696 29502539
Bronchopulmonary aspergillosis 17.37 10.89 4 70288 12340 29491895
Catatonia 17.37 10.89 35 70257 4433 29499802
Urticaria 17.28 10.89 69 70223 54591 29449644
Emotional disorder 17.26 10.89 37 70255 4894 29499341
Haematuria 17.15 10.89 51 70241 44088 29460147
Cerebral ventricle dilatation 17.09 10.89 15 70277 835 29503400
Tumour lysis syndrome 16.78 10.89 6 70286 13878 29490357
Blunted affect 16.76 10.89 10 70282 302 29503933
Decreased appetite 16.69 10.89 244 70048 145098 29359137
Cor pulmonale acute 16.61 10.89 9 70283 225 29504010
Rash maculo-papular 16.54 10.89 20 70272 24269 29479966
Thrombosis 16.53 10.89 50 70242 42995 29461240
Social avoidant behaviour 16.47 10.89 27 70265 2915 29501320
Male orgasmic disorder 16.40 10.89 7 70285 101 29504134
Action tremor 16.39 10.89 6 70286 56 29504179
Diastolic hypotension 16.32 10.89 5 70287 25 29504210
Food craving 16.27 10.89 10 70282 319 29503916
Sleep paralysis 16.25 10.89 8 70284 163 29504072
Heat stroke 16.23 10.89 15 70277 894 29503341
Tubulointerstitial nephritis 16.22 10.89 11 70281 17632 29486603
Physical deconditioning 16.14 10.89 14 70278 767 29503468
Hyperkalaemia 16.12 10.89 83 70209 61309 29442926
Hypokalaemia 16.11 10.89 63 70229 50140 29454095
Floppy infant 16.09 10.89 7 70285 106 29504129
Otospondylomegaepiphyseal dysplasia 16.03 10.89 7 70285 107 29504128
Contraindicated product administered 15.99 10.89 12 70280 18254 29485981
Cerebral microangiopathy 15.98 10.89 8 70284 169 29504066
Onychomycosis 15.94 10.89 22 70270 2040 29502195
Nervousness 15.89 10.89 61 70231 11245 29492990
Hospitalisation 15.87 10.89 56 70236 45932 29458303
Diarrhoea neonatal 15.85 10.89 5 70287 28 29504207
Bradykinesia 15.85 10.89 29 70263 3418 29500817
Hyponatraemic coma 15.85 10.89 5 70287 28 29504207
Head discomfort 15.84 10.89 28 70264 3214 29501021
Physical assault 15.80 10.89 16 70276 1068 29503167
Enuresis 15.76 10.89 22 70270 2062 29502173
Food aversion 15.75 10.89 10 70282 338 29503897
Neutrophil count decreased 15.75 10.89 52 70240 43515 29460720
Infantile vomiting 15.71 10.89 5 70287 29 29504206
Gambling disorder 15.61 10.89 19 70273 1556 29502679
Tricuspid valve sclerosis 15.56 10.89 5 70287 30 29504205
Oedema 15.56 10.89 47 70245 40436 29463799
Respiratory arrest 15.56 10.89 110 70182 25723 29478512
Hypoxia 15.49 10.89 59 70233 47320 29456915
CADASIL 15.43 10.89 6 70286 67 29504168
Rhinorrhoea 15.43 10.89 17 70275 21502 29482733
Coagulation factor VII level decreased 15.42 10.89 7 70285 118 29504117
Derealisation 15.36 10.89 12 70280 567 29503668
Pseudohyponatraemia 15.35 10.89 6 70286 68 29504167
Delirium 15.30 10.89 152 70140 39245 29464990
Reduced facial expression 15.29 10.89 13 70279 693 29503542
Unemployment 15.29 10.89 5 70287 32 29504203
Palmar-plantar erythrodysaesthesia syndrome 15.26 10.89 8 70284 14751 29489484
Crying 15.23 10.89 37 70255 5314 29498921
Selective mutism 15.20 10.89 6 70286 70 29504165
Product dose omission issue 15.19 10.89 151 70141 96232 29408003
Peripheral swelling 15.18 10.89 89 70203 63650 29440585
Antidepressant discontinuation syndrome 15.13 10.89 3 70289 0 29504235
Kleptomania 15.13 10.89 3 70289 0 29504235
Influenza 15.13 10.89 50 70242 41831 29462404
Magnetic resonance imaging spinal abnormal 15.12 10.89 6 70286 71 29504164
Dizziness 15.10 10.89 572 69720 189112 29315123
Cyanosis neonatal 15.08 10.89 9 70283 272 29503963
Suspected suicide 15.04 10.89 31 70261 3989 29500246
Meningocele 15.03 10.89 5 70287 34 29504201
Catecholamines urine increased 14.92 10.89 4 70288 11 29504224
Tinnitus 14.89 10.89 75 70217 15539 29488696
Cerebellar syndrome 14.84 10.89 21 70271 1993 29502242
Norepinephrine increased 14.66 10.89 4 70288 12 29504223
Urinary straining 14.66 10.89 4 70288 12 29504223
Condition aggravated 14.62 10.89 453 69839 145842 29358393
Laboratory test abnormal 14.61 10.89 13 70279 18172 29486063
Food interaction 14.44 10.89 14 70278 886 29503349
Sexually inappropriate behaviour 14.44 10.89 10 70282 392 29503843
Anal stenosis 14.42 10.89 7 70285 138 29504097
Substance abuser 14.35 10.89 6 70286 82 29504153
Blepharospasm 14.34 10.89 15 70277 1040 29503195
Acute myeloid leukaemia 14.26 10.89 11 70281 16502 29487733
Inflammation 14.16 10.89 20 70272 22708 29481527
Neoplasm progression 14.14 10.89 14 70278 18598 29485637
Cerebral disorder 14.04 10.89 22 70270 2286 29501949
Insulin resistance 14.02 10.89 11 70281 523 29503712
Ex-drug abuser 14.02 10.89 7 70285 147 29504088
Prescribed overdose 14.01 10.89 49 70243 8634 29495601
Peritonitis 13.96 10.89 9 70283 14815 29489420
C-reactive protein increased 13.91 10.89 56 70236 44207 29460028
Skull fractured base 13.85 10.89 7 70285 151 29504084
Obsessive-compulsive symptom 13.85 10.89 6 70286 90 29504145
Withdrawal catatonia 13.85 10.89 6 70286 90 29504145
Muscle necrosis 13.77 10.89 13 70279 796 29503439
Affect lability 13.64 10.89 27 70265 3375 29500860
Tunnel vision 13.52 10.89 10 70282 435 29503800
General physical health deterioration 13.49 10.89 168 70124 102689 29401546
Limited symptom panic attack 13.44 10.89 5 70287 49 29504186
Muscle tightness 13.44 10.89 31 70261 4307 29499928
Toxic epidermal necrolysis 13.39 10.89 14 70278 18139 29486096
Inhibitory drug interaction 13.39 10.89 17 70275 1453 29502782
Distributive shock 13.38 10.89 14 70278 971 29503264
Opisthotonus 13.35 10.89 10 70282 444 29503791
Congenital hydronephrosis 13.33 10.89 12 70280 691 29503544
Therapeutic response unexpected 13.30 10.89 48 70244 8590 29495645
Coma scale abnormal 13.28 10.89 27 70265 3442 29500793
Nonspecific reaction 13.26 10.89 15 70277 1136 29503099
Congenital skin dimples 13.25 10.89 7 70285 166 29504069
Stress 13.23 10.89 92 70200 21398 29482837
Central nervous system inflammation 13.22 10.89 6 70286 101 29504134
Dysgraphia 13.21 10.89 20 70272 2018 29502217
Pneumonia bacterial 13.20 10.89 3 70289 9340 29494895
Blood glucose increased 13.19 10.89 84 70208 58900 29445335
Tachyphrenia 13.07 10.89 15 70277 1154 29503081
Pre-existing condition improved 13.05 10.89 21 70271 2232 29502003
Renal disorder 12.99 10.89 21 70271 22574 29481661
Urine output decreased 12.99 10.89 3 70289 9235 29495000
Ventricular septal defect 12.96 10.89 27 70265 3502 29500733
Colitis 12.95 10.89 35 70257 31213 29473022
Panic disorder 12.86 10.89 15 70277 1175 29503060
Chills 12.84 10.89 108 70184 71192 29433043
Balance disorder 12.83 10.89 137 70155 36033 29468202
Blood urea increased 12.80 10.89 30 70262 28082 29476153
Anorgasmia 12.79 10.89 11 70281 596 29503639
Sleep terror 12.79 10.89 12 70280 729 29503506
Antineutrophil cytoplasmic antibody positive 12.73 10.89 11 70281 600 29503635
Dehydration 12.69 10.89 194 70098 114554 29389681
Diverticulitis 12.68 10.89 14 70278 17690 29486545
Drug reaction with eosinophilia and systemic symptoms 12.65 10.89 30 70262 27962 29476273
Upper respiratory tract infection 12.61 10.89 29 70263 27320 29476915
Vertebral foraminal stenosis 12.56 10.89 10 70282 486 29503749
Conjunctivitis viral 12.54 10.89 5 70287 60 29504175
Impulse-control disorder 12.50 10.89 15 70277 1210 29503025
Double inlet left ventricle 12.45 10.89 4 70288 24 29504211
Dissociative identity disorder 12.45 10.89 4 70288 24 29504211
Sclerodactylia 12.45 10.89 4 70288 24 29504211
Convulsive threshold lowered 12.44 10.89 10 70282 493 29503742
Gastric infection 12.42 10.89 14 70278 1056 29503179
Cerebrovascular accident 12.32 10.89 120 70172 76791 29427444
Tryptase increased 12.30 10.89 7 70285 193 29504042
Onychophagia 12.25 10.89 5 70287 64 29504171
Blood creatine phosphokinase increased 12.19 10.89 149 70143 40495 29463740
Chest discomfort 12.16 10.89 62 70230 45921 29458314
Leukopenia 12.15 10.89 79 70213 55124 29449111
Myelosuppression 12.10 10.89 7 70285 12220 29492015
Sinus tachycardia 12.07 10.89 69 70223 15000 29489235
Hypotonia 12.06 10.89 40 70252 6862 29497373
Fatigue 12.05 10.89 623 69669 316198 29188037
Dysphemia 12.01 10.89 16 70276 1434 29502801
Hypotension 12.01 10.89 361 69931 193993 29310242
Fungal infection 11.97 10.89 9 70283 13676 29490559
Pericardial effusion 11.93 10.89 20 70272 21188 29483047
Cerebellar haematoma 11.92 10.89 7 70285 205 29504030
Hepatotoxicity 11.86 10.89 15 70277 17852 29486383
Central nervous system stimulation 11.85 10.89 3 70289 6 29504229
Magical thinking 11.85 10.89 3 70289 6 29504229
Congenital ureterocele 11.85 10.89 3 70289 6 29504229
Saccadic eye movement 11.85 10.89 6 70286 130 29504105
Necrotising ulcerative gingivostomatitis 11.85 10.89 5 70287 70 29504165
Prostate cancer 11.82 10.89 27 70265 25500 29478735
Hepatic failure 11.82 10.89 37 70255 31475 29472760
Haemorrhage 11.79 10.89 61 70231 45011 29459224
Bite 11.78 10.89 5 70287 71 29504164
Alcohol poisoning 11.77 10.89 24 70268 3065 29501170
Psychomotor skills impaired 11.75 10.89 22 70270 2639 29501596
Gonadotrophin deficiency 11.69 10.89 4 70288 30 29504205
Squamous cell carcinoma of skin 11.63 10.89 4 70288 9482 29494753
Accommodation disorder 11.63 10.89 7 70285 215 29504020
Implant site infection 11.62 10.89 13 70279 973 29503262
Mental disorder 11.62 10.89 61 70231 12844 29491391
Bacteraemia 11.59 10.89 13 70279 16310 29487925
Dyspnoea exertional 11.57 10.89 46 70246 36444 29467791
Hypertensive emergency 11.57 10.89 12 70280 824 29503411
Productive cough 11.51 10.89 37 70255 31222 29473013
Haemolytic anaemia 11.50 10.89 4 70288 9415 29494820
Hypogonadism 11.50 10.89 16 70276 1495 29502740
Spondylolisthesis 11.50 10.89 11 70281 685 29503550
Hypersensitivity 11.49 10.89 76 70216 52827 29451408
Craniocerebral injury 11.48 10.89 22 70270 2686 29501549
Schizophrenia 11.43 10.89 38 70254 6527 29497708
Exposure via breast milk 11.38 10.89 17 70275 1695 29502540
Haemoptysis 11.36 10.89 36 70256 30514 29473721
Obstructive airways disorder 11.35 10.89 6 70286 11010 29493225
Clostridium difficile infection 11.30 10.89 13 70279 16128 29488107
Skin exfoliation 11.27 10.89 23 70269 22622 29481613
Psychiatric symptom 11.27 10.89 24 70268 3160 29501075
Tension headache 11.25 10.89 15 70277 1346 29502889
Flashback 11.22 10.89 6 70286 146 29504089
Hypersomnia 11.22 10.89 53 70239 10701 29493534
Psychomotor retardation 11.20 10.89 23 70269 2953 29501282
Repetitive speech 11.14 10.89 5 70287 82 29504153
Wheezing 11.12 10.89 41 70251 33199 29471036
Temperature regulation disorder 11.11 10.89 10 70282 576 29503659
Blood pressure decreased 11.10 10.89 63 70229 45414 29458821
Neonatal hypotension 11.07 10.89 6 70286 150 29504085
Full blood count decreased 11.07 10.89 13 70279 15979 29488256
Lip swelling 11.06 10.89 8 70284 12402 29491833
Univentricular heart 11.05 10.89 4 70288 36 29504199
Snoring 11.05 10.89 22 70270 2762 29501473
Acidosis 10.99 10.89 49 70243 9656 29494579
Abdominal distension 10.99 10.89 64 70228 45847 29458388
Antipsychotic drug level increased 10.97 10.89 24 70268 3219 29501016
Naevus flammeus 10.97 10.89 6 70286 153 29504082
Candida infection 10.95 10.89 12 70280 15213 29489022
Flight of ideas 10.94 10.89 8 70284 342 29503893
Blood lactate dehydrogenase increased 10.91 10.89 18 70274 19191 29485044
Small intestinal obstruction 10.90 10.89 9 70283 13052 29491183

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1933.54 9.85 2831 189508 221583 64084810
Serotonin syndrome 1383.23 9.85 1055 191284 38227 64268166
Intentional overdose 1124.10 9.85 1363 190976 88581 64217812
Toxicity to various agents 1040.42 9.85 2894 189445 360619 63945774
Suicide attempt 993.06 9.85 1140 191199 69867 64236526
Suicidal ideation 896.39 9.85 1048 191291 65494 64240899
Drug withdrawal syndrome 890.87 9.85 742 191597 30549 64275844
Overdose 772.39 9.85 1561 190778 158005 64148388
Intentional self-injury 477.75 9.85 508 191831 28536 64277857
Withdrawal syndrome 444.44 9.85 443 191896 23049 64283344
Drug abuse 425.41 9.85 1102 191237 131272 64175121
Coma 416.08 9.85 851 191488 86764 64219629
Poisoning deliberate 409.85 9.85 332 192007 13126 64293267
Sopor 390.55 9.85 462 191877 29199 64277194
Drug interaction 380.08 9.85 2101 190238 359982 63946411
Agitation 369.51 9.85 815 191524 87552 64218841
Mydriasis 331.51 9.85 311 192028 15001 64291392
Tremor 317.20 9.85 1068 191271 147162 64159231
Depression 315.43 9.85 1230 191109 182061 64124332
Anxiety 312.27 9.85 1314 191025 201335 64105058
Hyperhidrosis 306.21 9.85 943 191396 123977 64182416
Somnolence 263.65 9.85 1254 191085 202391 64104002
Febrile neutropenia 247.73 9.85 125 192214 187532 64118861
Electrocardiogram QT prolonged 244.39 9.85 651 191688 78797 64227596
Depressed mood 215.80 9.85 416 191923 40596 64265797
Disturbance in attention 212.91 9.85 414 191925 40660 64265733
Akathisia 210.23 9.85 213 192126 11297 64295096
Synovitis 208.94 9.85 25 192314 99065 64207328
Pneumonia 207.20 9.85 912 191427 558664 63747729
Seizure 201.77 9.85 1008 191331 165884 64140509
Joint swelling 199.13 9.85 209 192130 215173 64091220
Irritability 194.89 9.85 374 191965 36372 64270021
Nightmare 181.53 9.85 266 192073 20727 64285666
Pyrexia 178.07 9.85 960 191379 557684 63748709
Crying 172.91 9.85 254 192085 19836 64286557
Mania 170.15 9.85 226 192113 16060 64290333
Anaemia 169.69 9.85 571 191768 378109 63928284
Sepsis 167.11 9.85 268 192071 230073 64076320
Restlessness 157.28 9.85 359 191980 39426 64266967
Feeling abnormal 155.84 9.85 799 191540 132803 64173590
Infusion related reaction 152.64 9.85 159 192180 164308 64142085
Contraindicated product administered 149.63 9.85 67 192272 107762 64198631
Rash 147.08 9.85 786 191553 457763 63848630
Hand deformity 145.09 9.85 11 192328 62760 64243633
Anger 142.73 9.85 204 192135 15537 64290856
Drug hypersensitivity 139.92 9.85 1198 191141 236617 64069776
Poisoning 139.23 9.85 241 192098 21638 64284755
Off label use 136.54 9.85 1219 191120 631587 63674806
Insomnia 136.13 9.85 1033 191306 196803 64109590
Drug dependence 133.24 9.85 302 192037 33010 64273383
Panic attack 132.29 9.85 230 192109 20723 64285670
Infection 129.50 9.85 220 192119 184660 64121733
Neutropenia 127.69 9.85 333 192006 239291 64067102
Platelet count decreased 124.56 9.85 192 192147 167519 64138874
Generalised tonic-clonic seizure 122.91 9.85 327 192012 39530 64266863
Cardio-respiratory arrest 122.87 9.85 600 191739 97793 64208600
Psychomotor hyperactivity 121.90 9.85 181 192158 14270 64292123
Stress cardiomyopathy 118.21 9.85 142 192197 9115 64297278
Arthropathy 117.89 9.85 112 192227 120855 64185538
Systemic lupus erythematosus 114.49 9.85 44 192295 77568 64228825
Homicide 112.25 9.85 59 192280 1092 64305301
Pericarditis 111.27 9.85 25 192314 62491 64243902
Acute kidney injury 111.07 9.85 834 191505 448406 63857987
Tachycardia 110.80 9.85 795 191544 148784 64157609
Disease progression 109.27 9.85 158 192181 141522 64164871
Respiratory arrest 108.98 9.85 377 191962 52608 64253785
Confusional state 108.30 9.85 1223 191116 259921 64046472
Major depression 108.28 9.85 125 192214 7691 64298702
Thrombocytopenia 107.40 9.85 327 192012 223474 64082919
Extrapyramidal disorder 107.36 9.85 202 192137 19350 64287043
Gestational diabetes 104.93 9.85 105 192234 5485 64300908
Malignant neoplasm progression 103.70 9.85 110 192229 112761 64193632
Tearfulness 103.23 9.85 96 192243 4577 64301816
Cardiac arrest 102.32 9.85 798 191541 153266 64153127
Aggression 101.29 9.85 336 192003 45896 64260497
Rheumatoid arthritis 100.55 9.85 212 192127 164082 64142311
Bipolar disorder 100.23 9.85 112 192227 6649 64299744
Muscle rigidity 99.04 9.85 183 192156 17290 64289103
Renal impairment 98.87 9.85 156 192183 134861 64171532
Sedation 98.68 9.85 310 192029 41152 64265241
Dyspnoea 97.83 9.85 1532 190807 717142 63589251
Hyperreflexia 96.82 9.85 113 192226 7035 64299358
Hypersensitivity 96.44 9.85 284 192055 196168 64110225
Stomatitis 96.09 9.85 111 192228 109494 64196899
Electrocardiogram QRS complex prolonged 94.60 9.85 127 192212 9117 64297276
Glossodynia 93.25 9.85 38 192301 64658 64241735
Altered state of consciousness 91.69 9.85 285 192054 37617 64268776
Delusion 91.42 9.85 180 192159 17834 64288559
Rheumatoid factor positive 90.57 9.85 3 192336 34935 64271458
Swelling 90.48 9.85 216 192123 160002 64146391
Duodenal ulcer perforation 89.66 9.85 3 192336 34622 64271771
Pancytopenia 88.46 9.85 184 192155 143125 64163268
Hallucination, visual 87.48 9.85 230 192109 27604 64278789
Product substitution issue 85.29 9.85 174 192165 17687 64288706
Disorientation 84.99 9.85 361 191978 55467 64250926
Haemoglobin decreased 83.92 9.85 299 192040 194764 64111629
Hallucination, auditory 83.24 9.85 167 192172 16772 64289621
Mood swings 83.21 9.85 170 192169 17298 64289095
Helicobacter infection 82.55 9.85 9 192330 38353 64268040
Migraine 81.68 9.85 387 191952 62290 64244103
Gastrointestinal haemorrhage 79.88 9.85 172 192167 132140 64174253
Intentional product misuse 79.84 9.85 426 191913 71869 64234524
Cataplexy 79.35 9.85 42 192297 789 64305604
Tardive dyskinesia 78.91 9.85 116 192223 9062 64297331
Alopecia 78.81 9.85 243 192096 165447 64140946
Nervousness 77.84 9.85 229 192110 29327 64277066
Diarrhoea 77.59 9.85 1606 190733 721098 63585295
Restless legs syndrome 77.34 9.85 163 192176 16953 64289440
Somnambulism 75.93 9.85 85 192254 5056 64301337
Myoclonus 75.34 9.85 204 192135 24914 64281479
Sleep-related eating disorder 75.29 9.85 38 192301 644 64305749
Decorticate posture 74.67 9.85 30 192309 287 64306106
Bone marrow failure 74.43 9.85 25 192314 47927 64258466
Psychotic symptom 74.25 9.85 57 192282 2081 64304312
Myocardial depression 73.61 9.85 34 192305 469 64305924
Abnormal behaviour 72.44 9.85 243 192096 33379 64273014
Septic shock 72.38 9.85 127 192212 105310 64201083
Parkinsonism 72.19 9.85 143 192196 14230 64292163
Treatment failure 72.07 9.85 150 192189 116666 64189727
Pleural effusion 71.94 9.85 170 192169 126389 64180004
Thinking abnormal 71.84 9.85 126 192213 11430 64294963
Paraesthesia 71.44 9.85 663 191676 133859 64172534
Postmortem blood drug level increased 71.36 9.85 38 192301 723 64305670
Psychotic disorder 71.06 9.85 246 192093 34332 64272061
Neuroleptic malignant syndrome 70.99 9.85 199 192140 24797 64281596
Arthralgia 70.87 9.85 912 191427 441348 63865045
Antidepressant drug level increased 70.19 9.85 30 192309 340 64306053
Dyskinesia 69.77 9.85 267 192072 39121 64267272
Self-injurious ideation 69.31 9.85 65 192274 3132 64303261
Memory impairment 69.06 9.85 465 191874 85217 64221176
Respiratory failure 68.03 9.85 249 192090 160934 64145459
Hypomania 67.76 9.85 84 192255 5570 64300823
Antidepressant drug level above therapeutic 67.59 9.85 33 192306 519 64305874
Atrial fibrillation 67.26 9.85 272 192067 170817 64135576
Loss of consciousness 66.55 9.85 706 191633 147659 64158734
Homicidal ideation 66.39 9.85 64 192275 3193 64303200
Wound 64.31 9.85 80 192259 76397 64229996
Cytomegalovirus infection 63.97 9.85 16 192323 37183 64269210
Blood creatinine increased 63.25 9.85 201 192138 135581 64170812
Abnormal dreams 63.19 9.85 112 192227 10244 64296149
Mental impairment 62.95 9.85 146 192193 16197 64290196
Camptocormia 62.65 9.85 30 192309 451 64305942
Physical assault 62.14 9.85 45 192294 1501 64304892
Amnesia 62.13 9.85 297 192042 47972 64258421
Peripheral swelling 61.19 9.85 369 191970 208784 64097609
Pneumocystis jirovecii pneumonia 60.70 9.85 6 192333 27628 64278765
Apathy 59.14 9.85 114 192225 11118 64295275
Weight increased 59.13 9.85 929 191410 212419 64093974
Neuropathy peripheral 59.02 9.85 168 192171 117357 64189036
Meconium in amniotic fluid 58.37 9.85 18 192321 70 64306323
Galactorrhoea 57.74 9.85 59 192280 3160 64303233
Hepatic function abnormal 57.59 9.85 64 192275 64249 64242144
Suicidal behaviour 57.48 9.85 56 192283 2831 64303562
Mental disorder 55.97 9.85 190 192149 26255 64280138
Mood altered 55.36 9.85 137 192202 15842 64290551
Logorrhoea 54.69 9.85 64 192275 3995 64302398
Psychomotor retardation 54.69 9.85 72 192267 5071 64301322
Libido decreased 54.03 9.85 69 192270 4715 64301678
Interstitial lung disease 53.39 9.85 134 192205 97598 64208795
Hypertonia 53.03 9.85 79 192260 6246 64300147
Sinus tachycardia 52.01 9.85 212 192127 31976 64274417
Euphoric mood 51.96 9.85 80 192259 6511 64299882
Erythema 51.64 9.85 336 192003 186734 64119659
Therapeutic product effect decreased 51.47 9.85 174 192165 115177 64191216
Muscle twitching 50.79 9.85 148 192191 18850 64287543
Urinary incontinence 50.62 9.85 228 192111 35923 64270470
Anaphylactic reaction 50.56 9.85 79 192260 68585 64237808
Muscle injury 50.32 9.85 9 192330 26428 64279965
Bruxism 50.27 9.85 58 192281 3566 64302827
Impulsive behaviour 49.94 9.85 50 192289 2613 64303780
Hallucination 49.93 9.85 380 191959 72408 64233985
Dizziness 49.54 9.85 1654 190685 428509 63877884
Benzodiazepine drug level increased 48.74 9.85 20 192319 203 64306190
Coma scale abnormal 48.63 9.85 85 192254 7689 64298704
Toxic epidermal necrolysis 48.62 9.85 25 192314 37141 64269252
Inappropriate affect 48.41 9.85 36 192303 1252 64305141
Dissociation 48.31 9.85 52 192287 2959 64303434
Impaired healing 48.03 9.85 66 192273 60407 64245986
Abdominal discomfort 47.56 9.85 333 192006 181989 64124404
Dysphoria 47.54 9.85 62 192277 4326 64302067
Ascites 46.94 9.85 70 192269 61931 64244462
Discomfort 46.46 9.85 108 192231 80770 64225623
Sleep disorder 46.29 9.85 321 192018 59388 64247005
Accommodation disorder 46.24 9.85 25 192314 491 64305902
Cough 46.15 9.85 629 191710 301519 64004874
Nasopharyngitis 45.97 9.85 369 191970 195704 64110689
Blister 45.81 9.85 109 192230 80858 64225535
Personality disorder 45.59 9.85 63 192276 4648 64301745
Cardiac failure 45.05 9.85 222 192117 132151 64174242
Depressive symptom 44.83 9.85 61 192278 4435 64301958
Pyramidal tract syndrome 44.83 9.85 25 192314 523 64305870
Feelings of worthlessness 44.82 9.85 24 192315 462 64305931
Epilepsy 44.37 9.85 208 192131 33323 64273070
Feeling jittery 44.29 9.85 98 192241 10537 64295856
Clonus 44.17 9.85 71 192268 5996 64300397
Neovascularisation 44.09 9.85 32 192307 1071 64305322
White blood cell count decreased 43.80 9.85 283 192056 157554 64148839
Anorgasmia 43.66 9.85 30 192309 919 64305474
Erectile dysfunction 43.47 9.85 108 192231 12519 64293874
Loss of libido 43.01 9.85 44 192295 2360 64304033
Folliculitis 42.80 9.85 18 192321 30059 64276334
Oedema peripheral 42.60 9.85 411 191928 209906 64096487
Emotional disorder 42.53 9.85 107 192232 12500 64293893
C-reactive protein increased 42.45 9.85 143 192196 94766 64211627
Paranoia 42.39 9.85 126 192213 16226 64290167
Sleep disorder due to general medical condition, insomnia type 42.00 9.85 13 192326 26257 64280136
Cardiac failure congestive 41.61 9.85 224 192115 130356 64176037
Myelosuppression 41.46 9.85 10 192329 23820 64282573
Hepatic enzyme increased 41.35 9.85 223 192116 129720 64176673
Vertigo 40.99 9.85 309 192030 58702 64247691
Pleurothotonus 40.94 9.85 42 192297 2260 64304133
Social anxiety disorder 40.88 9.85 22 192317 428 64305965
Hyperkalaemia 40.85 9.85 159 192180 100970 64205423
Sinusitis 40.82 9.85 261 192078 145667 64160726
Oedema 40.79 9.85 139 192200 91796 64214597
Mucosal inflammation 40.61 9.85 78 192261 62506 64243887
Lung diffusion test abnormal 40.58 9.85 16 192323 145 64306248
Persistent genital arousal disorder 40.41 9.85 18 192321 227 64306166
Drug screen positive 40.29 9.85 66 192273 5663 64300730
Miosis 40.04 9.85 108 192231 13158 64293235
Cerebral infarction 39.97 9.85 38 192301 41006 64265387
Death 39.95 9.85 1115 191224 481590 63824803
Cytokine release syndrome 39.84 9.85 7 192332 20822 64285571
Fluid retention 39.81 9.85 73 192266 59533 64246860
Blood bilirubin increased 39.78 9.85 69 192270 57484 64248909
Panic disorder 39.72 9.85 45 192294 2712 64303681
Respiratory depression 39.14 9.85 156 192183 23287 64283106
International normalised ratio increased 39.13 9.85 114 192225 79053 64227340
Total lung capacity increased 38.90 9.85 25 192314 683 64305710
Hostility 38.77 9.85 40 192299 2167 64304226
Obsessive-compulsive disorder 38.71 9.85 59 192280 4759 64301634
Foetal death 38.61 9.85 66 192273 5864 64300529
Hereditary non-polyposis colorectal cancer syndrome 38.55 9.85 8 192331 0 64306393
Amniorrhexis 38.30 9.85 10 192329 17 64306376
Abulia 38.26 9.85 27 192312 864 64305529
Delirium 38.21 9.85 344 191995 68850 64237543
Cardiogenic shock 37.80 9.85 194 192145 32233 64274160
Opsoclonus myoclonus 37.70 9.85 16 192323 178 64306215
Lower respiratory tract infection 37.42 9.85 150 192189 94464 64211929
Feeling of despair 37.14 9.85 42 192297 2526 64303867
Persistent depressive disorder 37.05 9.85 28 192311 998 64305395
Inappropriate antidiuretic hormone secretion 36.96 9.85 148 192191 22141 64284252
Tinnitus 36.90 9.85 200 192139 33933 64272460
Metabolic syndrome 36.71 9.85 40 192299 2308 64304085
Mobility decreased 36.60 9.85 132 192207 85708 64220685
Persecutory delusion 36.39 9.85 53 192286 4105 64302288
Libido increased 36.16 9.85 35 192304 1755 64304638
Plasma cell myeloma 35.87 9.85 51 192288 46024 64260369
Colitis 35.62 9.85 76 192263 58598 64247795
Social avoidant behaviour 35.49 9.85 55 192284 4502 64301891
Leukopenia 35.48 9.85 168 192171 101074 64205319
Maternal exposure during pregnancy 35.46 9.85 156 192183 95728 64210665
Bezoar 35.27 9.85 38 192301 2165 64304228
Bronchopulmonary aspergillosis 35.25 9.85 7 192332 19078 64287315
General physical health deterioration 35.12 9.85 415 191924 204010 64102383
Alcoholism 35.05 9.85 47 192292 3370 64303023
Product use issue 34.87 9.85 287 192052 151428 64154965
Acute myocardial infarction 34.74 9.85 100 192239 69618 64236775
Fall 34.71 9.85 1547 190792 415279 63891114
Sexual dysfunction 34.46 9.85 66 192273 6405 64299988
Adjustment disorder with mixed anxiety and depressed mood 34.27 9.85 12 192327 75 64306318
Anticholinergic syndrome 34.17 9.85 41 192298 2628 64303765
Renal failure 33.91 9.85 362 191977 181326 64125067
Haematuria 33.73 9.85 82 192257 60389 64246004
Hypocalcaemia 33.73 9.85 45 192294 41708 64264685
Pain 33.43 9.85 1331 191008 552180 63754213
Drug eruption 33.41 9.85 35 192304 36101 64270292
Multiple organ dysfunction syndrome 33.40 9.85 172 192167 101241 64205152
Reversible cerebral vasoconstriction syndrome 33.36 9.85 38 192301 2304 64304089
Nephropathy toxic 33.25 9.85 6 192333 17508 64288885
Middle insomnia 33.17 9.85 99 192240 12778 64293615
Self esteem decreased 33.06 9.85 25 192314 892 64305501
Drug screen false positive 33.01 9.85 26 192313 986 64305407
Tachyphrenia 32.95 9.85 34 192305 1842 64304551
Negative thoughts 32.89 9.85 29 192310 1289 64305104
Diverticulitis 32.88 9.85 40 192299 38578 64267815
Tumour lysis syndrome 32.21 9.85 9 192330 19431 64286962
Suspected suicide 31.90 9.85 76 192263 8578 64297815
Victim of sexual abuse 31.76 9.85 18 192321 389 64306004
Nystagmus 31.68 9.85 78 192261 8990 64297403
Head discomfort 31.45 9.85 92 192247 11742 64294651
Antipsychotic drug level above therapeutic 31.38 9.85 33 192306 1828 64304565
Hypersomnia 31.17 9.85 129 192210 19588 64286805
Acute myeloid leukaemia 30.99 9.85 22 192317 27441 64278952
Transplant rejection 30.87 9.85 7 192332 17394 64288999
Neutrophil count decreased 30.77 9.85 122 192217 77074 64229319
Hypothermia 30.68 9.85 129 192210 19727 64286666
Cardiotoxicity 30.36 9.85 83 192256 10191 64296202
Osteonecrosis of jaw 30.11 9.85 45 192294 39780 64266613
Hyponatraemia 30.08 9.85 615 191724 147724 64158669
Depression suicidal 30.03 9.85 37 192302 2438 64303955
Myelodysplastic syndrome 29.95 9.85 23 192316 27556 64278837
Pneumonitis 29.94 9.85 66 192273 50299 64256094
Bacteraemia 29.79 9.85 22 192317 26889 64279504
Derealisation 29.76 9.85 29 192310 1466 64304927
Tubulointerstitial nephritis 29.65 9.85 29 192310 30880 64275513
Gastrointestinal disorder 29.63 9.85 152 192187 89557 64216836
HELLP syndrome 29.60 9.85 21 192318 678 64305715
Endometriosis 29.55 9.85 39 192300 2753 64303640
Hot flush 29.29 9.85 237 192102 45998 64260395
Dry mouth 29.20 9.85 292 192047 60126 64246267
Red blood cell sedimentation rate increased 29.17 9.85 30 192309 31205 64275188
Rapid eye movement sleep behaviour disorder 29.11 9.85 16 192323 325 64306068
Dependence 29.07 9.85 34 192305 2121 64304272
Cognitive disorder 28.96 9.85 271 192068 54816 64251577
Parkinsonism hyperpyrexia syndrome 28.91 9.85 14 192325 216 64306177
Endolymphatic hydrops 28.91 9.85 6 192333 0 64306393
Bradyphrenia 28.81 9.85 77 192262 9329 64297064
Postmortem blood drug level abnormal 28.70 9.85 20 192319 627 64305766
Irritable bowel syndrome 28.47 9.85 42 192297 37327 64269066
Skin candida 28.37 9.85 30 192309 1673 64304720
Kleptomania 28.31 9.85 8 192331 21 64306372
Prescribed overdose 28.29 9.85 128 192211 20203 64286190
Tension 28.04 9.85 45 192294 3795 64302598
Haematotoxicity 27.81 9.85 3 192336 12893 64293500
Drug use disorder 27.75 9.85 58 192281 5996 64300397
Unemployment 27.71 9.85 9 192330 43 64306350
Palmar-plantar erythrodysaesthesia syndrome 27.69 9.85 27 192312 28792 64277601
Alcohol interaction 27.37 9.85 48 192291 4353 64302040
Macrophages increased 27.35 9.85 13 192326 192 64306201
Right ventricular failure 27.27 9.85 15 192324 21456 64284937
Rheumatoid nodule 27.13 9.85 3 192336 12648 64293745
Toxicologic test abnormal 26.74 9.85 25 192314 1200 64305193
Pruritus 26.73 9.85 718 191621 311682 63994711
Epstein-Barr virus infection 26.69 9.85 3 192336 12485 64293908
Enuresis 26.54 9.85 37 192302 2753 64303640
Product residue present 26.47 9.85 40 192299 3202 64303191
Rhabdomyolysis 26.36 9.85 402 191937 91324 64215069
Pain in extremity 26.08 9.85 696 191643 302389 64004004
Cytopenia 25.94 9.85 7 192332 15464 64290929
Cogwheel rigidity 25.90 9.85 37 192302 2816 64303577
Urinary retention 25.84 9.85 242 192097 48959 64257434
Antipsychotic drug level increased 25.82 9.85 51 192288 5064 64301329
Drug ineffective for unapproved indication 25.69 9.85 170 192169 30963 64275430
Ejaculation disorder 25.62 9.85 17 192322 491 64305902
Upper respiratory tract infection 25.37 9.85 121 192218 72664 64233729
Thermophobia 25.34 9.85 9 192330 59 64306334
Drug intolerance 25.31 9.85 401 191938 187591 64118802
Vasoplegia syndrome 25.29 9.85 36 192303 2731 64303662
Panic reaction 25.15 9.85 44 192295 3983 64302410
Respiratory tract inflammation 25.13 9.85 20 192319 770 64305623
Skin necrosis 24.96 9.85 6 192333 14323 64292070
Pressure of speech 24.93 9.85 22 192317 979 64305414
Tenosynovitis 24.90 9.85 3 192336 11830 64294563
Malignant mediastinal neoplasm 24.85 9.85 17 192322 517 64305876
Neurotoxicity 24.83 9.85 27 192312 27377 64279016
Haemoptysis 24.70 9.85 70 192269 48978 64257415
Herpes zoster 24.58 9.85 137 192202 79050 64227343
Substance abuse 24.47 9.85 72 192267 9220 64297173
Pathogen resistance 24.47 9.85 4 192335 12539 64293854
Somatic symptom disorder 24.42 9.85 29 192310 1839 64304554
Thrombosis 24.29 9.85 118 192221 70524 64235869
Electrocardiogram QRS complex shortened 24.28 9.85 18 192321 623 64305770
Tonic convulsion 24.25 9.85 29 192310 1852 64304541
Hip arthroplasty 24.23 9.85 17 192322 21334 64285059
Tongue biting 24.13 9.85 28 192311 1732 64304661
Nervous system disorder 24.12 9.85 134 192205 22944 64283449
Psychiatric symptom 24.11 9.85 56 192283 6217 64300176
ECG P wave inverted 24.09 9.85 5 192334 0 64306393
COVID-19 24.07 9.85 106 192233 65034 64241359
Schizophreniform disorder 24.06 9.85 11 192328 148 64306245
Decreased interest 24.02 9.85 39 192300 3321 64303072
Hepatocellular injury 24.01 9.85 223 192116 45012 64261381
Affect lability 24.00 9.85 70 192269 8920 64297473
Hospitalisation 23.95 9.85 129 192210 75078 64231315
Frustration tolerance decreased 23.90 9.85 55 192284 6070 64300323
Hepatic failure 23.73 9.85 85 192254 55309 64251084
Melaena 23.72 9.85 81 192258 53467 64252926
Therapeutic response unexpected 23.63 9.85 107 192232 16894 64289499
Ill-defined disorder 23.59 9.85 61 192278 43991 64262402
Abnormal weight gain 23.56 9.85 31 192308 2182 64304211
Oropharyngeal pain 23.31 9.85 162 192177 88705 64217688
Psoriatic arthropathy 23.12 9.85 60 192279 43221 64263172
Acquired amegakaryocytic thrombocytopenia 23.05 9.85 6 192333 10 64306383
Blood urea increased 22.99 9.85 62 192277 44091 64262302
Renal papillary necrosis 22.89 9.85 14 192325 350 64306043
Neurodegenerative disorder 22.80 9.85 15 192324 427 64305966
Brain death 22.78 9.85 47 192292 4814 64301579
Distributive shock 22.70 9.85 28 192311 1847 64304546
Kidney duplex 22.69 9.85 6 192333 11 64306382
Iodine allergy 22.67 9.85 16 192323 512 64305881
Coma acidotic 22.53 9.85 10 192329 125 64306268
Rhinorrhoea 22.51 9.85 97 192242 59872 64246521
Congestive cardiomyopathy 22.49 9.85 75 192264 10269 64296124
Hepatotoxicity 22.44 9.85 54 192285 39908 64266485
Peritonitis 22.29 9.85 25 192314 24998 64281395
Dysarthria 22.24 9.85 273 192066 59133 64247260
Transfusion 22.23 9.85 13 192326 17981 64288412
Haemolytic anaemia 22.22 9.85 10 192329 16043 64290350
Stress 22.15 9.85 277 192062 60257 64246136
Thrombotic microangiopathy 22.09 9.85 11 192328 16644 64289749
Intentional product use issue 22.09 9.85 180 192159 95184 64211209
External auditory canal atresia 22.03 9.85 6 192333 13 64306380
Loose associations 21.96 9.85 8 192331 57 64306336
Upper gastrointestinal haemorrhage 21.90 9.85 45 192294 35175 64271218
Poor quality sleep 21.82 9.85 113 192226 18838 64287555
Retinal coloboma 21.73 9.85 6 192333 14 64306379
Iris coloboma 21.73 9.85 6 192333 14 64306379
Bipolar II disorder 21.72 9.85 13 192326 312 64306081
Hyperthermia 21.71 9.85 98 192241 15452 64290941
Drug resistance 21.70 9.85 45 192294 35057 64271336
Helplessness 21.68 9.85 13 192326 313 64306080
Cellulitis 21.59 9.85 177 192162 93480 64212913
Sleep terror 21.58 9.85 22 192317 1175 64305218
Erythema dyschromicum perstans 21.49 9.85 8 192331 61 64306332
Drug abuser 21.40 9.85 51 192288 5757 64300636
Dialysis 21.23 9.85 12 192327 16908 64289485
Cataract 21.08 9.85 80 192259 51182 64255211
Phagophobia 20.97 9.85 7 192332 37 64306356
Neoplasm progression 20.97 9.85 58 192281 40906 64265487
Device related infection 20.91 9.85 37 192302 30589 64275804
Otospondylomegaepiphyseal dysplasia 20.82 9.85 7 192332 38 64306355
Blood lactate dehydrogenase increased 20.79 9.85 42 192297 33036 64273357
Food aversion 20.78 9.85 17 192322 681 64305712
Splenomegaly 20.78 9.85 14 192325 17947 64288446
Obsessive thoughts 20.76 9.85 20 192319 997 64305396
Eye movement disorder 20.73 9.85 57 192282 7022 64299371
Paradoxical drug reaction 20.70 9.85 52 192287 6068 64300325
Merycism 20.67 9.85 11 192328 209 64306184
Antidepressant discontinuation syndrome 20.64 9.85 5 192334 5 64306388
Liver function test increased 20.62 9.85 38 192301 30932 64275461
Myocardial infarction 20.58 9.85 359 191980 165462 64140931
Emotional poverty 20.55 9.85 17 192322 692 64305701
Dyspnoea exertional 20.54 9.85 132 192207 73598 64232795
Speech disorder 20.53 9.85 228 192111 48213 64258180
Headache 20.51 9.85 1839 190500 527628 63778765
Flight of ideas 20.51 9.85 17 192322 694 64305699
Asphyxia 20.48 9.85 69 192270 9497 64296896
Aplastic anaemia 20.34 9.85 8 192331 13912 64292481
Phaeochromocytoma malignant 20.34 9.85 8 192331 72 64306321
Type 2 diabetes mellitus 20.27 9.85 172 192167 33848 64272545
Skin maceration 20.09 9.85 7 192332 43 64306350
Graft versus host disease 20.08 9.85 8 192331 13805 64292588
Reduced facial expression 20.06 9.85 28 192311 2085 64304308
Haemophagocytic lymphohistiocytosis 20.01 9.85 14 192325 17595 64288798
Trunk injury 19.95 9.85 6 192333 21 64306372
Cytomegalovirus viraemia 19.94 9.85 4 192335 10824 64295569
Second primary malignancy 19.91 9.85 6 192333 12331 64294062
Hypervigilance 19.84 9.85 14 192325 448 64305945
Disturbance in sexual arousal 19.84 9.85 10 192329 169 64306224
Pneumonia bacterial 19.83 9.85 10 192329 15025 64291368
Increased appetite 19.82 9.85 71 192268 10075 64296318
External ear disorder 19.78 9.85 8 192331 78 64306315
Burnout syndrome 19.76 9.85 12 192327 296 64306097
Foaming at mouth 19.63 9.85 25 192314 1704 64304689
Liver disorder 19.60 9.85 87 192252 53264 64253129
Incoherent 19.56 9.85 56 192283 7062 64299331
Orthostatic intolerance 19.54 9.85 24 192315 1576 64304817
Basal cell carcinoma 19.51 9.85 39 192300 30799 64275594
Hyperchloraemia 19.51 9.85 19 192320 960 64305433
Perinatal depression 19.47 9.85 12 192327 304 64306089
Histamine level increased 19.43 9.85 8 192331 82 64306311
Clostridium difficile infection 19.42 9.85 50 192289 36113 64270280
Lung disorder 19.39 9.85 104 192235 60596 64245797
Injection site pain 19.18 9.85 226 192113 111182 64195211
Vision blurred 19.15 9.85 377 191962 89939 64216454
Multiple sclerosis 19.15 9.85 109 192230 18832 64287561
Injection site erythema 19.09 9.85 128 192211 70672 64235721
COVID-19 pneumonia 18.91 9.85 13 192326 16491 64289902
Muscle mass 18.87 9.85 13 192326 400 64305993
Diffuse large B-cell lymphoma 18.72 9.85 4 192335 10357 64296036
Balance disorder 18.70 9.85 353 191986 83573 64222820
Bradypnoea 18.69 9.85 45 192294 5114 64301279
Testicular atrophy 18.60 9.85 12 192327 330 64306063
Ocular hyperaemia 18.55 9.85 24 192315 22540 64283853
Abnormal sleep-related event 18.54 9.85 17 192322 796 64305597
Generalised oedema 18.39 9.85 21 192318 20832 64285561
Impaired driving ability 18.39 9.85 42 192297 4612 64301781
Haematocrit decreased 18.39 9.85 92 192247 54563 64251830
Drug level increased 18.36 9.85 169 192170 34027 64272366
Cardiomyopathy 18.30 9.85 134 192205 25222 64281171
Attention deficit hyperactivity disorder 18.26 9.85 31 192308 2739 64303654
Soft tissue injury 18.19 9.85 23 192316 1556 64304837
Cold sweat 18.18 9.85 97 192242 16358 64290035
Catatonia 18.15 9.85 57 192282 7563 64298830
Imprisonment 17.93 9.85 14 192325 524 64305869
Transient psychosis 17.89 9.85 7 192332 62 64306331
Gambling 17.88 9.85 11 192328 278 64306115
Gambling disorder 17.84 9.85 25 192314 1869 64304524
Wheezing 17.80 9.85 154 192185 80425 64225968
Hypokinesia 17.77 9.85 97 192242 16499 64289894
Pre-existing condition improved 17.75 9.85 42 192297 4720 64301673
Eosinophilic pustular folliculitis 17.74 9.85 8 192331 104 64306289
Female sexual dysfunction 17.63 9.85 6 192333 34 64306359
Proteinuria 17.59 9.85 35 192304 27688 64278705
Normal pressure hydrocephalus 17.56 9.85 13 192326 449 64305944
Sleep paralysis 17.48 9.85 14 192325 544 64305849
Wrong dose 17.45 9.85 20 192319 1221 64305172
Vitamin K decreased 17.42 9.85 7 192332 67 64306326
Heart rate increased 17.40 9.85 401 191938 98274 64208119
Prostate cancer 17.39 9.85 20 192319 19775 64286618
Antisocial behaviour 17.37 9.85 14 192325 549 64305844
Osteomyelitis 17.36 9.85 35 192304 27552 64278841
Hyperacusis 17.33 9.85 25 192314 1920 64304473
Pulmonary mass 17.33 9.85 28 192311 23988 64282405
Starvation ketoacidosis 17.28 9.85 8 192331 111 64306282
Hypercalcaemia 17.21 9.85 43 192296 31373 64275020
Purging 17.20 9.85 6 192333 37 64306356
Musculoskeletal stiffness 17.19 9.85 261 192078 122945 64183448
Disseminated intravascular coagulation 17.16 9.85 45 192294 32303 64274090
CYP3A4 polymorphism 17.15 9.85 7 192332 70 64306323
Potentiating drug interaction 17.13 9.85 57 192282 7795 64298598
Nodule 17.03 9.85 17 192322 17930 64288463
Productive cough 17.03 9.85 138 192201 73065 64233328
Muscle tightness 17.00 9.85 72 192267 11043 64295350
Priapism 17.00 9.85 37 192302 3933 64302460
Pericardial effusion 16.97 9.85 60 192279 39194 64267199
Blood creatine phosphokinase increased 16.96 9.85 257 192082 58301 64248092
Back pain 16.95 9.85 593 191746 249578 64056815
Depressed level of consciousness 16.95 9.85 339 192000 81097 64225296
Sluggishness 16.95 9.85 46 192293 5624 64300769
Anticonvulsant drug level above therapeutic 16.90 9.85 18 192321 1012 64305381
False positive investigation result 16.82 9.85 16 192323 785 64305608
Sleep apnoea syndrome 16.82 9.85 149 192190 29683 64276710
Immunodeficiency 16.81 9.85 14 192325 16110 64290283
Slow response to stimuli 16.78 9.85 22 192317 1543 64304850
Hypokalaemia 16.75 9.85 259 192080 121644 64184749
Arachnoid cyst 16.72 9.85 11 192328 313 64306080
Jaundice 16.70 9.85 81 192258 48431 64257962
Cerebellar haematoma 16.69 9.85 14 192325 581 64305812
Anhedonia 16.67 9.85 83 192256 13623 64292770
Hypotonia 16.67 9.85 72 192267 11140 64295253
Sciatic nerve neuropathy 16.63 9.85 11 192328 316 64306077
Small intestinal obstruction 16.53 9.85 28 192311 23545 64282848
Catecholamines urine increased 16.51 9.85 5 192334 18 64306375
Palpitations 16.43 9.85 418 191921 104070 64202323
Hyperprolactinaemia 16.41 9.85 37 192302 4028 64302365
Affective disorder 16.39 9.85 50 192289 6530 64299863
Impaired work ability 16.33 9.85 89 192250 15130 64291263
Blood potassium increased 16.32 9.85 33 192306 25947 64280446
Aspartate aminotransferase increased 16.29 9.85 255 192084 119533 64186860
Pulmonary contusion 16.25 9.85 7 192332 81 64306312
Chest discomfort 16.18 9.85 246 192093 115860 64190533
Yawning 16.10 9.85 19 192320 1197 64305196
Cerebrovascular accident 16.08 9.85 301 192038 137282 64169111
Peak expiratory flow rate decreased 16.04 9.85 14 192325 614 64305779
Chronic kidney disease 15.97 9.85 104 192235 57815 64248578
Localised infection 15.97 9.85 42 192297 30119 64276274
Activation syndrome 15.96 9.85 10 192329 261 64306132
Akinesia 15.90 9.85 31 192308 3048 64303345
Concussion 15.90 9.85 56 192283 7882 64298511
Cold agglutinins positive 15.87 9.85 6 192333 48 64306345
Implant site extravasation 15.85 9.85 15 192324 731 64305662
Alanine aminotransferase increased 15.69 9.85 306 192033 138725 64167668
Male orgasmic disorder 15.66 9.85 6 192333 50 64306343
Focal dyscognitive seizures 15.64 9.85 32 192307 3258 64303135
Dysphemia 15.62 9.85 31 192308 3088 64303305
Toxic cardiomyopathy 15.56 9.85 11 192328 353 64306040
Bradykinesia 15.56 9.85 49 192290 6511 64299882
Metastases to bone 15.53 9.85 23 192316 20412 64285981
Urticaria 15.50 9.85 328 192011 146989 64159404
Adrenal insufficiency 15.50 9.85 27 192312 22460 64283933
Blood ethanol increased 15.47 9.85 14 192325 644 64305749
Full blood count abnormal 15.44 9.85 146 192193 29611 64276782
Fear 15.37 9.85 108 192231 20063 64286330
Pulmonary arterial hypertension 15.28 9.85 33 192306 25334 64281059
Movement disorder 15.16 9.85 115 192224 21885 64284508
Pneumothorax 15.14 9.85 31 192308 24267 64282126
Forced expiratory volume decreased 15.11 9.85 50 192289 6817 64299576
Aspergillus infection 14.99 9.85 16 192323 16363 64290030
Respiratory tract infection 14.98 9.85 59 192280 37348 64269045
Dystonia 14.96 9.85 102 192237 18763 64287630
Exposure via ingestion 14.89 9.85 40 192299 4862 64301531
Hallucination, tactile 14.88 9.85 12 192327 471 64305922
Bladder trabeculation 14.88 9.85 6 192333 58 64306335
Skin ulcer 14.80 9.85 74 192265 43900 64262493
Conjunctivitis viral 14.80 9.85 8 192331 157 64306236
Inadequate analgesia 14.73 9.85 35 192304 3943 64302450
Feeling drunk 14.72 9.85 36 192303 4131 64302262
Anaemia of pregnancy 14.70 9.85 6 192333 60 64306333
Substance abuser 14.69 9.85 7 192332 104 64306289
Kidney transplant rejection 14.69 9.85 5 192334 9506 64296887
Parasomnia 14.62 9.85 12 192327 483 64305910
Feeling guilty 14.61 9.85 15 192324 808 64305585
Cystitis haemorrhagic 14.52 9.85 3 192336 7953 64298440
Depersonalisation/derealisation disorder 14.49 9.85 21 192318 1619 64304774
Creatinine renal clearance decreased 14.45 9.85 13 192326 14408 64291985
Tricuspid valve sclerosis 14.45 9.85 5 192334 30 64306363
Hyponatraemic coma 14.45 9.85 5 192334 30 64306363
Hypnopompic hallucination 14.44 9.85 6 192333 63 64306330
Ataxia 14.42 9.85 114 192225 21970 64284423
Genital hypoaesthesia 14.40 9.85 8 192331 166 64306227
Cerebral vasoconstriction 14.40 9.85 18 192321 1204 64305189
Narcolepsy 14.36 9.85 17 192322 1074 64305319
Blood catecholamines increased 14.31 9.85 5 192334 31 64306362
Left ventricular dysfunction 14.24 9.85 93 192246 16861 64289532
Parkinsonian gait 14.22 9.85 15 192324 834 64305559
Psychiatric decompensation 14.21 9.85 26 192313 2437 64303956
Labour complication 14.20 9.85 6 192333 66 64306327
Neurological examination abnormal 14.19 9.85 12 192327 504 64305889
Eosinophilic myocarditis 14.18 9.85 15 192324 837 64305556
Apallic syndrome 14.07 9.85 15 192324 844 64305549
Osteoporosis 14.06 9.85 71 192268 42009 64264384
Tympanic membrane disorder 14.03 9.85 8 192331 175 64306218
Renal disorder 14.02 9.85 56 192283 35309 64271084
Acute hepatitis B 14.02 9.85 11 192328 415 64305978
Renal tubular necrosis 13.96 9.85 28 192311 22082 64284311
Rash pruritic 13.91 9.85 107 192232 57297 64249096
Metastases to lung 13.87 9.85 15 192324 15249 64291144
Cerebral haematoma 13.80 9.85 50 192289 7135 64299258
Exposure during pregnancy 13.80 9.85 316 192023 77359 64229034
Decreased appetite 13.73 9.85 692 191647 280597 64025796
Food craving 13.72 9.85 19 192320 1405 64304988
Arthritis 13.67 9.85 172 192167 83642 64222751
Selective mutism 13.66 9.85 6 192333 73 64306320
Indifference 13.56 9.85 9 192330 260 64306133
Wrong technique in product usage process 13.55 9.85 126 192213 64848 64241545
Peritonitis bacterial 13.54 9.85 5 192334 9038 64297355
Cardiac failure chronic 13.54 9.85 5 192334 9036 64297357
Post-traumatic neck syndrome 13.49 9.85 22 192317 1880 64304513
Respiratory tract congestion 13.49 9.85 17 192322 16148 64290245
Barotrauma 13.44 9.85 8 192331 190 64306203
Metastases to central nervous system 13.40 9.85 13 192326 13899 64292494
Myopathy 13.34 9.85 20 192319 17660 64288733
Hypoalbuminaemia 13.33 9.85 20 192319 17654 64288739
Sternal fracture 13.32 9.85 24 192315 2223 64304170
Haemorrhage 13.26 9.85 162 192177 79189 64227204
Ligament pain 13.26 9.85 8 192331 195 64306198
Drug level above therapeutic 13.23 9.85 48 192291 6853 64299540
Emotional distress 13.22 9.85 165 192174 35873 64270520
Blood calcium decreased 13.21 9.85 36 192303 25518 64280875
Incontinence 13.20 9.85 71 192268 12010 64294383
Anal incontinence 13.16 9.85 84 192255 15112 64291281
Pneumonia fungal 13.14 9.85 5 192334 8872 64297521
Hypervolaemia 13.13 9.85 64 192275 38221 64268172
Accidental death 12.97 9.85 32 192307 3693 64302700
Ulcer 12.96 9.85 31 192308 22959 64283434
Judgement impaired 12.95 9.85 16 192323 1057 64305336
Violence-related symptom 12.94 9.85 13 192326 682 64305711
Blood glucose increased 12.92 9.85 210 192129 97863 64208530
Chills 12.91 9.85 311 192028 136953 64169440
Angle closure glaucoma 12.82 9.85 26 192313 2631 64303762
Squamous cell carcinoma of skin 12.77 9.85 10 192329 11866 64294527
Injection site rash 12.68 9.85 17 192322 15725 64290668
Hypnagogic hallucination 12.66 9.85 7 192332 144 64306249
Escherichia infection 12.61 9.85 16 192323 15152 64291241
Tendonitis 12.54 9.85 26 192313 20256 64286137
Skin texture abnormal 12.52 9.85 10 192329 387 64306006
Pre-eclampsia 12.51 9.85 44 192295 6187 64300206
Partner stress 12.51 9.85 9 192330 297 64306096
Extrasystoles 12.51 9.85 46 192293 6612 64299781
Pseudophaeochromocytoma 12.48 9.85 6 192333 91 64306302
Device occlusion 12.48 9.85 7 192332 9906 64296487
Alcohol use 12.44 9.85 36 192303 4566 64301827
Conversion disorder 12.35 9.85 20 192319 1699 64304694
Limited symptom panic attack 12.34 9.85 5 192334 49 64306344
Femur fracture 12.33 9.85 56 192283 34079 64272314
Oesophagitis 12.32 9.85 29 192310 21601 64284792
Device malfunction 12.31 9.85 21 192318 17612 64288781
Renal aplasia 12.31 9.85 6 192333 94 64306299
Ideas of reference 12.24 9.85 7 192332 154 64306239
Patella fracture 12.22 9.85 19 192320 1559 64304834
Hepatic encephalopathy 12.20 9.85 28 192311 21038 64285355
Allodynia 12.18 9.85 17 192322 1266 64305127
Loose tooth 12.18 9.85 27 192312 2907 64303486
Exposure via transplant 12.17 9.85 4 192335 20 64306373
Withdrawal catatonia 12.16 9.85 7 192332 156 64306237
Status epilepticus 12.11 9.85 108 192231 21555 64284838
Aplasia pure red cell 12.09 9.85 3 192336 7011 64299382
Deja vu 12.08 9.85 5 192334 52 64306341
Hepatocellular carcinoma 12 9.85 5 192334 8398 64297995
Therapy non-responder 12.00 9.85 132 192207 65767 64240626
Consciousness fluctuating 11.98 9.85 19 192320 1586 64304807
Large intestine perforation 11.89 9.85 12 192327 12592 64293801
Personality change 11.88 9.85 54 192285 8539 64297854
Dropped head syndrome 11.88 9.85 8 192331 237 64306156
Joint range of motion decreased 11.78 9.85 25 192314 19318 64287075
Rash maculo-papular 11.71 9.85 87 192252 46939 64259454
Multiple sclerosis relapse 11.70 9.85 180 192159 40955 64265438
Acute respiratory failure 11.67 9.85 94 192245 49840 64256553
Ovarian cancer stage III 11.66 9.85 7 192332 169 64306224
Agoraphobia 11.63 9.85 11 192328 536 64305857
Dreamy state 11.60 9.85 5 192334 58 64306335
Morbihan disease 11.56 9.85 4 192335 24 64306369
Full blood count decreased 11.54 9.85 32 192307 22550 64283843
Gastritis 11.51 9.85 77 192262 42541 64263852
Facial nerve disorder 11.50 9.85 12 192327 659 64305734
Creutzfeldt-Jakob disease 11.44 9.85 7 192332 175 64306218
Coronary artery disease 11.43 9.85 120 192219 60313 64246080
Pulmonary fibrosis 11.41 9.85 48 192291 29830 64276563
Micturition urgency 11.40 9.85 61 192278 10298 64296095
Infective pulmonary exacerbation of cystic fibrosis 11.39 9.85 11 192328 11785 64294608
Pain in jaw 11.33 9.85 73 192266 40682 64265711
Coordination abnormal 11.33 9.85 80 192259 14884 64291509
Grandiosity 11.32 9.85 11 192328 554 64305839
Stevens-Johnson syndrome 11.32 9.85 58 192281 34191 64272202
Psychomotor skills impaired 11.30 9.85 31 192308 3814 64302579
Blood lactic acid increased 11.28 9.85 61 192278 10340 64296053
Mixed liver injury 11.26 9.85 39 192300 5442 64300951
Flashback 11.26 9.85 8 192331 259 64306134
Mechanical urticaria 11.25 9.85 9 192330 349 64306044
Bladder dilatation 11.25 9.85 20 192319 1834 64304559
Juvenile myoclonic epilepsy 11.23 9.85 5 192334 63 64306330
CYP2D6 polymorphism 11.18 9.85 3 192336 6 64306387
Cystic lymphangioma 11.18 9.85 3 192336 6 64306387
Magical thinking 11.18 9.85 3 192336 6 64306387
Platelet aggregation abnormal 11.16 9.85 4 192335 27 64306366
Intestinal anastomosis complication 11.15 9.85 8 192331 263 64306130
Snoring 11.13 9.85 35 192304 4647 64301746
Slow speech 11.12 9.85 21 192318 2016 64304377
Neuropsychiatric syndrome 11.09 9.85 6 192333 118 64306275
Head injury 11.05 9.85 148 192191 32694 64273699
Torsade de pointes 10.99 9.85 89 192250 17274 64289119
Uveitis 10.99 9.85 13 192326 12695 64293698
Pseudomonas infection 10.99 9.85 23 192316 17860 64288533
Hyperphagia 10.97 9.85 22 192317 2209 64304184
Antiphospholipid antibodies 10.91 9.85 6 192333 122 64306271
Device issue 10.91 9.85 33 192306 22615 64283778
Mixed anxiety and depressive disorder 10.87 9.85 7 192332 192 64306201
Accident at work 10.87 9.85 14 192325 965 64305428
Central nervous system necrosis 10.81 9.85 8 192331 276 64306117
Multiple-drug resistance 10.79 9.85 3 192336 6499 64299894
Treatment noncompliance 10.78 9.85 186 192153 43296 64263097
Tic 10.75 9.85 24 192315 2595 64303798
Enterocolitis 10.71 9.85 12 192327 12006 64294387
Drug specific antibody 10.71 9.85 21 192318 2074 64304319
Influenza 10.68 9.85 239 192100 106292 64200101
Pneumonia viral 10.63 9.85 5 192334 7817 64298576
Skull fractured base 10.61 9.85 8 192331 284 64306109
Acidosis 10.61 9.85 90 192249 17705 64288688
Bipolar I disorder 10.61 9.85 19 192320 1752 64304641
Asthenia 10.60 9.85 1116 191223 426928 63879465
Hyperemesis gravidarum 10.60 9.85 9 192330 380 64306013
Tuberculosis 10.58 9.85 14 192325 13024 64293369
Gonadotrophin deficiency 10.58 9.85 4 192335 32 64306361
Dermatitis acneiform 10.57 9.85 6 192333 8437 64297956
Hypoxia 10.56 9.85 192 192147 87957 64218436
Unresponsive to stimuli 10.56 9.85 210 192129 50183 64256210
Coagulation factor VII level decreased 10.55 9.85 7 192332 202 64306191
Feeling of body temperature change 10.55 9.85 35 192304 4779 64301614
Pseudohyponatraemia 10.53 9.85 6 192333 131 64306262
Pulmonary vein occlusion 10.53 9.85 6 192333 131 64306262
Intellectual disability 10.52 9.85 14 192325 996 64305397
Right ventricular systolic pressure decreased 10.51 9.85 5 192334 74 64306319
Sleep talking 10.47 9.85 14 192325 1001 64305392
Schizophrenia 10.47 9.85 63 192276 11105 64295288
Norepinephrine increased 10.45 9.85 5 192334 75 64306318
Tanning 10.45 9.85 5 192334 75 64306318
Aortic stenosis 10.45 9.85 3 192336 6362 64300031
Alcohol withdrawal syndrome 10.36 9.85 19 192320 1784 64304609
Anuria 10.32 9.85 94 192245 18870 64287523
Clumsiness 10.32 9.85 24 192315 2667 64303726
Febrile bone marrow aplasia 10.29 9.85 11 192328 11244 64295149
Diastolic hypotension 10.29 9.85 6 192333 137 64306256
Alcohol poisoning 10.29 9.85 32 192307 4223 64302170
Hypotonia neonatal 10.28 9.85 5 192334 78 64306315
Human chorionic gonadotropin positive 10.27 9.85 4 192335 35 64306358
Disorganised speech 10.27 9.85 18 192321 1632 64304761
Action tremor 10.27 9.85 9 192330 397 64305996
Obsessive-compulsive symptom 10.25 9.85 6 192333 138 64306255
Skin disorder 10.25 9.85 45 192294 27635 64278758
Appendicectomy 10.24 9.85 21 192318 2142 64304251
Anaphylactic shock 10.23 9.85 51 192288 30277 64276116
Renal injury 10.21 9.85 19 192320 15410 64290983
Hepatic cirrhosis 10.20 9.85 42 192297 26256 64280137
Marital problem 10.20 9.85 7 192332 214 64306179
Trismus 10.18 9.85 35 192304 4866 64301527
Device leakage 10.17 9.85 6 192333 8260 64298133
Language disorder 10.17 9.85 24 192315 2693 64303700
Urinary tract infection 10.12 9.85 576 191763 231020 64075373
Poor personal hygiene 10.11 9.85 10 192329 515 64305878
Dysuria 10.10 9.85 179 192160 41878 64264515
Constricted affect 10.09 9.85 3 192336 10 64306383
Salivary gland disorder 10.05 9.85 8 192331 308 64306085
Urinary hesitation 10.02 9.85 28 192311 3482 64302911
Colon cancer 10.02 9.85 14 192325 12725 64293668
Blood triglycerides increased 10.01 9.85 93 192246 18773 64287620
Gun shot wound 9.96 9.85 14 192325 1050 64305343
Candida infection 9.94 9.85 54 192285 31365 64275028
Orgasmic sensation decreased 9.89 9.85 4 192335 39 64306354
Epistaxis 9.88 9.85 220 192119 97911 64208482
Prothrombin time prolonged 9.88 9.85 20 192319 15721 64290672
Skin discolouration 9.88 9.85 63 192276 35192 64271201
Victim of crime 9.87 9.85 9 192330 418 64305975
Large cell lung cancer metastatic 9.87 9.85 3 192336 11 64306382
Muscle necrosis 9.86 9.85 15 192324 1208 64305185

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Selective eating disorder 49.02 27.13 91 1793 1098 81696

Pharmacologic Action:

SourceCodeDescription
ATC N06AX16 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D000068760 Serotonin and Noradrenaline Reuptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:51039 dopamine reuptake inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
FDA EPC N0000175749 Serotonin and Norepinephrine Reuptake Inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Social phobia indication 25501002 DOID:11257
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Menopausal flushing off-label use 198436008
Neuropathic pain off-label use 247398009
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperthyroidism contraindication 34486009 DOID:7998
Upper gastrointestinal hemorrhage contraindication 37372002
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Mania contraindication 231494001
Hypomania contraindication 231496004
Interstitial lung disease contraindication 233703007 DOID:3082
Disease of liver contraindication 235856003 DOID:409
Hypertriglyceridemia contraindication 302870006
Serotonin syndrome contraindication 371089000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.05 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 5.98 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 5.55 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.44 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.65 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.70 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.05 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 7.60 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.44 CHEMBL
Transporter Transporter Ki 6.86 CHEMBL
Transporter Transporter IC50 6.19 CHEMBL

External reference:

IDSource
4023901 VUID
N0000021906 NUI
D00821 KEGG_DRUG
99300-78-4 SECONDARY_CAS_RN
4020846 VANDF
4023901 VANDF
C0078569 UMLSCUI
CHEBI:9943 CHEBI
CHEMBL637 ChEMBL_ID
DB00285 DRUGBANK_ID
CHEMBL1201066 ChEMBL_ID
D000069470 MESH_DESCRIPTOR_UI
5656 PUBCHEM_CID
7321 IUPHAR_LIGAND_ID
6358 INN_ID
GRZ5RCB1QG UNII
151692 RXNORM
5669 MMSL
594 MMSL
87651 MMSL
d03181 MMSL
004428 NDDF
004429 NDDF
108432009 SNOMEDCT_US
108434005 SNOMEDCT_US
372490001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0833 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 36 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0836 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 36 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0837 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 36 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7384 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7385 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7386 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9147 TABLET 25 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9148 TABLET 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9149 TABLET 50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9157 TABLET 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9163 TABLET 100 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2604 TABLET 150 mg ORAL ANDA 30 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2605 TABLET 225 mg ORAL ANDA 30 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0527-2606 TABLET 75 mg ORAL ANDA 29 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-6566 TABLET 37.50 mg ORAL ANDA 25 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-6567 TABLET 75 mg ORAL ANDA 23 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7557 TABLET 50 mg ORAL ANDA 23 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7558 TABLET 100 mg ORAL ANDA 23 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7621 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7622 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8122 TABLET 75 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8346 TABLET 75 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6468 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 31 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6469 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 31 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6470 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 31 sections
venlafaxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7075 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 31 sections
venlafaxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7076 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 31 sections
venlafaxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7077 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 31 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 13668-018 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 32 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 13668-018 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 32 sections