venlafaxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2813 93413-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • venlafaxine
  • (+/-)-Venlafaxine
  • velafax
  • venlafaxin
  • venlafexine
  • venlafaxine hydrochloride
  • effexor
  • WY-45,030
  • venlafaxine HCl
A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
  • Molecular weight: 277.41
  • Formula: C17H27NO2
  • CLOGP: 3.27
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.70
  • ALOGS: -3.08
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 31.39 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 4.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.59 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 45 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 14 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.73 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1993 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1455.21 10.02 1986 189554 143687 63153795
Drug withdrawal syndrome 1227.92 10.02 853 190687 26341 63271141
Intentional overdose 1170.56 10.02 1275 190265 72877 63224605
Serotonin syndrome 996.51 10.02 768 190772 27914 63269568
Suicidal ideation 906.93 10.02 1028 190512 61393 63236089
Toxicity to various agents 890.98 10.02 2163 189377 245087 63052395
Suicide attempt 876.13 10.02 998 190542 59920 63237562
Overdose 704.50 10.02 1253 190287 113825 63183657
Intentional self-injury 605.92 10.02 550 190990 25137 63272345
Withdrawal syndrome 541.31 10.02 463 191077 19534 63277948
Poisoning deliberate 532.40 10.02 363 191177 10855 63286627
Drug abuse 509.87 10.02 840 190700 71678 63225804
Drug interaction 490.62 10.02 1663 189877 227468 63070014
Systemic lupus erythematosus 423.04 10.02 63 191477 208855 63088627
Hand deformity 414.61 10.02 15 191525 159442 63138040
Synovitis 413.54 10.02 42 191498 186876 63110606
Coma 402.78 10.02 708 190832 63656 63233826
Sopor 375.52 10.02 396 191144 21768 63275714
Glossodynia 373.73 10.02 49 191491 178827 63118655
Agitation 369.61 10.02 654 190886 59103 63238379
Contraindicated product administered 340.30 10.02 116 191424 217532 63079950
Joint swelling 335.65 10.02 297 191243 327369 62970113
Depression 331.70 10.02 1321 190219 195171 63102311
Arthropathy 331.01 10.02 147 191393 234645 63062837
Pericarditis 329.96 10.02 16 191524 131563 63165919
Mydriasis 311.73 10.02 271 191269 11685 63285797
Somnolence 307.75 10.02 1209 190331 177476 63120006
Tremor 305.10 10.02 985 190555 131254 63166228
Anxiety 301.08 10.02 1377 190163 216164 63081318
Wound 274.97 10.02 76 191464 163187 63134295
Alopecia 270.79 10.02 374 191166 337162 62960320
Electrocardiogram QT prolonged 265.99 10.02 568 190972 58962 63238520
Crying 264.34 10.02 339 191201 23004 63274478
Hyperhidrosis 264.03 10.02 820 190720 107016 63190466
Swelling 257.02 10.02 271 191269 275107 63022375
Infusion related reaction 255.56 10.02 219 191321 245302 63052180
Seizure 250.15 10.02 924 190616 131710 63165772
Helicobacter infection 243.68 10.02 8 191532 92777 63204705
Rheumatoid factor positive 238.49 10.02 3 191537 84403 63213079
Abdominal discomfort 228.05 10.02 386 191154 320499 62976983
Rash 220.50 10.02 908 190632 559963 62737519
Selective eating disorder 211.73 10.02 110 191430 1962 63295520
Discomfort 200.28 10.02 129 191411 167245 63130237
Akathisia 192.78 10.02 184 191356 8962 63288520
Foetal exposure during pregnancy 191.38 10.02 345 191195 31617 63265865
Treatment failure 186.60 10.02 195 191345 198848 63098634
Hypersensitivity 184.11 10.02 379 191161 292306 63005176
Therapeutic product effect decreased 183.66 10.02 187 191353 193000 63104482
Irritability 178.28 10.02 333 191207 31361 63266121
Rheumatoid arthritis 176.87 10.02 309 191231 253510 63043972
Infection 172.74 10.02 265 191275 228908 63068574
Hypotonia neonatal 171.47 10.02 81 191459 1165 63296317
Depressed mood 169.82 10.02 375 191165 39816 63257666
Disturbance in attention 167.81 10.02 362 191178 37827 63259655
Muscle injury 166.87 10.02 7 191533 65338 63232144
Anger 163.72 10.02 195 191345 12261 63285221
Panic attack 162.66 10.02 263 191277 22068 63275414
Nightmare 159.23 10.02 240 191300 18954 63278528
Feeling abnormal 157.52 10.02 872 190668 147520 63149962
Blister 152.63 10.02 102 191438 129712 63167770
Folliculitis 152.33 10.02 17 191523 70300 63227182
Generalised tonic-clonic seizure 151.05 10.02 295 191245 28721 63268761
Cardiac arrest 150.16 10.02 615 190925 91930 63205552
Restlessness 146.75 10.02 294 191246 29159 63268323
Pain 139.27 10.02 1497 190043 739131 62558351
Peripheral swelling 138.05 10.02 381 191159 265561 63031921
Off label use 136.73 10.02 1339 190201 673123 62624359
Hepatic enzyme increased 134.91 10.02 253 191287 202075 63095407
Drug dependence 133.67 10.02 254 191286 24229 63273253
Aggression 133.54 10.02 248 191292 23250 63274232
Tachycardia 133.25 10.02 706 190834 117450 63180032
Product substitution issue 132.67 10.02 200 191340 15796 63281686
Sleep disorder due to general medical condition, insomnia type 131.99 10.02 6 191534 52211 63245271
Impaired healing 131.09 10.02 73 191467 102469 63195013
Pneumonia 129.04 10.02 828 190712 455939 62841543
Arthralgia 128.84 10.02 1100 190440 568610 62728872
Drug intolerance 127.10 10.02 490 191050 308171 62989311
Febrile neutropenia 122.70 10.02 106 191434 118343 63179139
Cardio-respiratory arrest 119.08 10.02 425 191115 59534 63237948
Foetal death 117.35 10.02 155 191385 10825 63286657
Respiratory arrest 116.41 10.02 285 191255 32360 63265122
Stomatitis 115.83 10.02 149 191391 138576 63158906
Small for dates baby 114.22 10.02 93 191447 3658 63293824
Hyperreflexia 113.12 10.02 113 191427 5821 63291661
Gestational diabetes 112.92 10.02 133 191407 8263 63289219
Extrapyramidal disorder 112.89 10.02 168 191372 13116 63284366
Product use issue 112.87 10.02 318 191222 220202 63077280
Intentional product misuse 111.89 10.02 421 191119 60496 63236986
Nasopharyngitis 111.61 10.02 393 191147 253864 63043618
Disorientation 109.73 10.02 314 191226 39138 63258344
Mobility decreased 108.71 10.02 123 191417 121036 63176446
Psychomotor hyperactivity 108.56 10.02 147 191393 10516 63286966
Mania 107.40 10.02 158 191382 12209 63285273
Mood swings 102.95 10.02 192 191348 18056 63279426
Maternal exposure during pregnancy 102.12 10.02 332 191208 219730 63077752
Poisoning 102.03 10.02 163 191377 13537 63283945
Muscle rigidity 101.42 10.02 148 191392 11352 63286130
Drug withdrawal syndrome neonatal 100.29 10.02 68 191472 2013 63295469
Galactorrhoea 99.97 10.02 90 191450 4065 63293417
Altered state of consciousness 99.41 10.02 229 191311 25001 63272481
Pyrexia 98.96 10.02 925 190615 469553 62827929
Atrial septal defect 96.81 10.02 112 191428 6826 63290656
Major depression 93.22 10.02 118 191422 7900 63289582
C-reactive protein abnormal 92.97 10.02 14 191526 46082 63251400
Antidepressant drug level above therapeutic 91.05 10.02 38 191502 399 63297083
Abnormal dreams 90.81 10.02 134 191406 10382 63287100
Irritable bowel syndrome 89.99 10.02 70 191470 82342 63215140
Ill-defined disorder 89.83 10.02 69 191471 81686 63215796
Sepsis 88.96 10.02 207 191333 152916 63144566
Tearfulness 88.62 10.02 84 191456 4055 63293427
Mental disorder 87.90 10.02 222 191318 25697 63271785
Sleep-related eating disorder 86.44 10.02 45 191495 806 63296676
Insomnia 86.26 10.02 1011 190529 214241 63083241
Lung diffusion test abnormal 85.77 10.02 34 191506 309 63297173
Psoriatic arthropathy 85.31 10.02 90 191450 91430 63206052
Myoclonus 84.62 10.02 163 191377 15705 63281777
Electrocardiogram QRS complex prolonged 83.09 10.02 96 191444 5842 63291640
Hip arthroplasty 82.39 10.02 21 191519 47625 63249857
Musculoskeletal stiffness 81.21 10.02 285 191255 184333 63113149
Hallucination 80.89 10.02 354 191186 54463 63243019
Anaemia 79.64 10.02 538 191002 292892 63004590
Newborn persistent pulmonary hypertension 79.34 10.02 29 191511 206 63297276
Platelet count decreased 78.42 10.02 144 191396 115978 63181504
Lower respiratory tract infection 78.35 10.02 177 191363 132130 63165352
Stress cardiomyopathy 78.14 10.02 118 191422 9332 63288150
Sinusitis 76.73 10.02 387 191153 226266 63071216
Homicide 75.28 10.02 32 191508 353 63297129
Decorticate posture 75.27 10.02 30 191510 277 63297205
Nervousness 75.19 10.02 235 191305 30744 63266738
Camptocormia 75.08 10.02 30 191510 279 63297203
Antidepressant drug level increased 74.43 10.02 30 191510 286 63297196
Myocardial depression 73.17 10.02 34 191506 470 63297012
Cardiogenic shock 73.13 10.02 165 191375 17767 63279715
Apathy 72.99 10.02 110 191430 8684 63288798
Loss of consciousness 72.81 10.02 607 190933 117514 63179968
Mental impairment 72.58 10.02 143 191397 14008 63283474
Tardive dyskinesia 71.50 10.02 107 191433 8395 63289087
Vertigo 71.03 10.02 363 191177 59524 63237958
Lymphocytic oesophagitis 69.98 10.02 17 191523 17 63297465
Neutropenia 68.65 10.02 283 191257 174722 63122760
Bradycardia neonatal 68.23 10.02 40 191500 912 63296570
Abnormal behaviour 68.00 10.02 179 191361 21247 63276235
Thinking abnormal 67.71 10.02 118 191422 10525 63286957
Neonatal asphyxia 67.51 10.02 28 191512 289 63297193
Sinus tachycardia 67.33 10.02 193 191347 24075 63273407
Disease progression 67.31 10.02 171 191369 122587 63174895
Paraesthesia 67.23 10.02 747 190793 156219 63141263
Amnesia 65.28 10.02 336 191204 55249 63242233
Psychomotor retardation 65.27 10.02 69 191471 3801 63293681
Dizziness 64.39 10.02 1725 189815 428200 62869282
Gastrointestinal disorder 62.93 10.02 195 191345 131044 63166438
Malignant mediastinal neoplasm 62.06 10.02 44 191496 1402 63296080
Physical assault 61.50 10.02 37 191503 886 63296596
Self-injurious ideation 60.85 10.02 56 191484 2603 63294879
Neonatal seizure 59.99 10.02 30 191510 492 63296990
C-reactive protein increased 59.97 10.02 122 191418 94585 63202897
Paranoia 59.87 10.02 118 191422 11561 63285921
Confusional state 59.87 10.02 1024 190516 235356 63062126
Neonatal respiratory failure 59.44 10.02 25 191515 268 63297214
Large for dates baby 59.19 10.02 29 191511 454 63297028
Nystagmus 59.18 10.02 83 191457 6137 63291345
Pleurothotonus 57.78 10.02 41 191499 1308 63296174
Respiratory depression 56.82 10.02 127 191413 13588 63283894
Inappropriate affect 56.70 10.02 35 191505 879 63296603
Red blood cell sedimentation rate increased 56.64 10.02 31 191509 43951 63253531
Full blood count abnormal 56.41 10.02 217 191323 31500 63265982
Impulsive behaviour 56.28 10.02 43 191497 1540 63295942
Muscle twitching 56.10 10.02 158 191382 19510 63277972
Congenital tricuspid valve incompetence 55.55 10.02 18 191522 84 63297398
Drug screen false positive 55.21 10.02 34 191506 850 63296632
Neuroleptic malignant syndrome 54.93 10.02 116 191424 11940 63285542
Migraine 54.85 10.02 514 191026 102832 63194650
Homicidal ideation 54.53 10.02 44 191496 1708 63295774
Parkinsonism 54.16 10.02 106 191434 10333 63287149
Renal impairment 54.11 10.02 116 191424 88239 63209243
General physical health deterioration 53.73 10.02 371 191169 201031 63096451
Myelosuppression 53.22 10.02 5 191535 23698 63273784
Haemoglobin decreased 52.94 10.02 242 191298 145243 63152239
Oedema 51.97 10.02 138 191402 97484 63199998
Neovascularisation 51.84 10.02 36 191504 1109 63296373
Product residue present 51.81 10.02 62 191478 3917 63293565
Hot flush 51.80 10.02 297 191243 50862 63246620
Mood altered 51.80 10.02 128 191412 14615 63282867
Bipolar disorder 51.61 10.02 89 191451 7871 63289611
Benzodiazepine drug level increased 51.42 10.02 20 191520 172 63297310
Respiratory disorder neonatal 51.40 10.02 37 191503 1208 63296274
Urinary incontinence 51.29 10.02 212 191328 31802 63265680
Intentional product use issue 51.28 10.02 205 191335 127687 63169795
Hallucination, auditory 51.18 10.02 117 191423 12707 63284775
Hallucination, visual 51.15 10.02 151 191389 19147 63278335
Libido decreased 51.15 10.02 51 191489 2621 63294861
Panic reaction 51.03 10.02 63 191477 4111 63293371
Bruxism 51.03 10.02 58 191482 3467 63294015
Sedation 50.83 10.02 242 191298 38567 63258915
Lung disorder 50.78 10.02 68 191472 62193 63235289
Self esteem decreased 50.15 10.02 29 191511 644 63296838
Emotional disorder 50.04 10.02 119 191421 13260 63284222
Hostility 49.94 10.02 43 191497 1829 63295653
Somnambulism 49.84 10.02 72 191468 5471 63292011
Suicidal behaviour 49.84 10.02 50 191490 2589 63294893
Knee arthroplasty 49.73 10.02 54 191486 54152 63243330
Meconium in amniotic fluid 49.17 10.02 22 191518 277 63297205
Neonatal hypoxia 49.02 10.02 28 191512 607 63296875
Dyskinesia 48.99 10.02 209 191331 31793 63265689
Cataplexy 48.84 10.02 36 191504 1220 63296262
Patent ductus arteriosus 48.54 10.02 62 191478 4188 63293294
Malignant neoplasm progression 48.49 10.02 110 191430 82011 63215471
Somatic symptom disorder 47.68 10.02 49 191491 2611 63294871
Dissociation 47.39 10.02 51 191489 2868 63294614
Restless legs syndrome 47.23 10.02 143 191397 18388 63279094
Accommodation disorder 47.06 10.02 23 191517 358 63297124
Diarrhoea 46.99 10.02 1726 189814 713640 62583842
Thrombocytopenia 46.73 10.02 266 191274 150891 63146591
Psychotic disorder 46.62 10.02 177 191363 25535 63271947
Tinnitus 46.54 10.02 222 191318 35406 63262076
Coma scale abnormal 46.43 10.02 67 191473 5086 63292396
Delusion 46.16 10.02 108 191432 11909 63285573
Depressive symptom 45.53 10.02 59 191481 4043 63293439
Drug ineffective 45.45 10.02 2636 188904 1042129 62255353
Feeling of despair 45.43 10.02 45 191495 2294 63295188
Anorgasmia 44.97 10.02 26 191514 577 63296905
Bezoar 44.72 10.02 37 191503 1489 63295993
Hyperprolactinaemia 44.71 10.02 57 191483 3843 63293639
Euphoric mood 44.71 10.02 64 191476 4823 63292659
Opsoclonus myoclonus 44.34 10.02 17 191523 140 63297342
Pruritus 44.14 10.02 796 190744 360657 62936825
Skin candida 44.12 10.02 38 191502 1617 63295865
Pain in extremity 44.03 10.02 719 190821 330767 62966715
Dyspnoea 43.76 10.02 1594 189946 659719 62637763
Persistent genital arousal disorder 43.73 10.02 20 191520 266 63297216
Hypothermia 43.64 10.02 114 191426 13467 63284015
Weight increased 43.24 10.02 1061 190479 259731 63037751
Pancytopenia 43.02 10.02 149 191391 96784 63200698
Joint range of motion decreased 43.02 10.02 22 191518 32406 63265076
Clonus 42.83 10.02 61 191479 4575 63292907
Hyponatraemia 42.32 10.02 520 191020 111380 63186102
Single umbilical artery 42.20 10.02 19 191521 243 63297239
Hypersomnia 42.02 10.02 135 191405 17920 63279562
Adverse drug reaction 41.43 10.02 114 191426 79600 63217882
Dysarthria 41.32 10.02 245 191295 42466 63255016
Alcohol interaction 40.72 10.02 43 191497 2366 63295116
Personality disorder 40.37 10.02 67 191473 5744 63291738
Transient tachypnoea of the newborn 39.94 10.02 15 191525 116 63297366
Electrocardiogram QRS complex shortened 39.78 10.02 22 191518 447 63297035
Pulmonary fibrosis 39.55 10.02 37 191503 39772 63257710
Panic disorder 39.27 10.02 44 191496 2589 63294893
Drug hypersensitivity 39.10 10.02 1220 190320 309467 62988015
Bone erosion 39.09 10.02 4 191536 17713 63279769
Memory impairment 38.78 10.02 483 191057 103775 63193707
Death 38.33 10.02 849 190691 373532 62923950
Anticholinergic syndrome 37.59 10.02 41 191499 2341 63295141
Blood immunoglobulin E increased 37.58 10.02 52 191488 3797 63293685
Drug ineffective for unapproved indication 37.31 10.02 202 191338 33861 63263621
Congenital vesicoureteric reflux 37.14 10.02 10 191530 20 63297462
Colitis microscopic 37.04 10.02 85 191455 9254 63288228
Pneumocystis jirovecii pneumonia 36.85 10.02 4 191536 16910 63280572
Slow response to stimuli 36.62 10.02 28 191512 1004 63296478
VACTERL syndrome 36.56 10.02 9 191531 10 63297472
Nervous system disorder 36.37 10.02 132 191408 18634 63278848
Libido increased 36.09 10.02 31 191509 1314 63296168
Drug tolerance decreased 35.94 10.02 5 191535 17468 63280014
Congenital hearing disorder 35.67 10.02 9 191531 12 63297470
Bipolar II disorder 35.64 10.02 19 191521 358 63297124
Yawning 35.49 10.02 28 191512 1052 63296430
Drug screen positive 35.39 10.02 49 191491 3580 63293902
Pulmonary haemorrhage neonatal 35.34 10.02 10 191530 26 63297456
Ventricular septal defect 35.25 10.02 54 191486 4324 63293158
Neonatal respiratory distress syndrome 35.21 10.02 43 191497 2775 63294707
Endometriosis 35.17 10.02 60 191480 5260 63292222
Blood creatinine increased 35.08 10.02 141 191399 87703 63209779
Rheumatoid nodule 35.08 10.02 5 191535 17150 63280332
Negative thoughts 34.77 10.02 26 191514 901 63296581
Amniorrhexis 34.54 10.02 10 191530 29 63297453
Psychotic symptom 34.03 10.02 32 191508 1529 63295953
Anaphylactic reaction 34.00 10.02 95 191445 66005 63231477
Temperature regulation disorder 33.94 10.02 64 191476 6068 63291414
Hypomania 33.72 10.02 65 191475 6265 63291217
Speech disorder 33.66 10.02 224 191316 40405 63257077
Atrial fibrillation 33.53 10.02 210 191330 116426 63181056
Tonic convulsion 33.00 10.02 29 191511 1268 63296214
Burnout syndrome 32.83 10.02 15 191525 199 63297283
Epilepsy 32.74 10.02 165 191375 26900 63270582
Pleural effusion 32.74 10.02 157 191383 93053 63204429
Logorrhoea 32.50 10.02 39 191501 2471 63295011
Vitamin K decreased 32.45 10.02 8 191532 9 63297473
Rapid eye movement sleep behaviour disorder 32.43 10.02 17 191523 309 63297173
Asphyxia 32.35 10.02 63 191477 6118 63291364
Reversible cerebral vasoconstriction syndrome 32.31 10.02 40 191500 2618 63294864
Hypoventilation neonatal 32.20 10.02 9 191531 22 63297460
Torsade de pointes 32.14 10.02 101 191439 13250 63284232
Renal papillary necrosis 32.13 10.02 16 191524 260 63297222
Agitation neonatal 31.89 10.02 20 191520 517 63296965
Hypoglycaemia 31.48 10.02 298 191242 59767 63237715
Dropped head syndrome 31.38 10.02 14 191526 175 63297307
Herpes zoster 31.29 10.02 135 191405 82327 63215155
Palpitations 31.27 10.02 496 191044 112274 63185208
Toxic epidermal necrolysis 30.99 10.02 19 191521 25315 63272167
Postmortem blood drug level abnormal 30.94 10.02 17 191523 341 63297141
Hypotonia 30.93 10.02 79 191461 9206 63288276
Leukopenia 30.90 10.02 124 191416 77166 63220316
Parkinsonism hyperpyrexia syndrome 30.86 10.02 13 191527 140 63297342
Therapeutic product effect incomplete 30.61 10.02 236 191304 124820 63172662
Adjustment disorder with mixed anxiety and depressed mood 30.37 10.02 12 191528 108 63297374
Neonatal behavioural syndrome 30.30 10.02 10 191530 50 63297432
Brain death 30.23 10.02 44 191496 3366 63294116
Substance abuse 30.19 10.02 53 191487 4754 63292728
Phagophobia 30.14 10.02 10 191530 51 63297431
Gastrointestinal haemorrhage 30.13 10.02 134 191406 81042 63216440
Social avoidant behaviour 30.12 10.02 41 191499 2947 63294535
Enuresis 30.12 10.02 38 191502 2535 63294947
Loss of libido 30.07 10.02 28 191512 1321 63296161
Haemangioma congenital 29.81 10.02 18 191522 434 63297048
Cold sweat 29.80 10.02 92 191448 11955 63285527
Respiratory tract inflammation 29.74 10.02 20 191520 584 63296898
Dissociative disorder 29.70 10.02 17 191523 370 63297112
Encephalopathy 29.66 10.02 209 191331 38411 63259071
Tachyphrenia 29.63 10.02 28 191512 1346 63296136
Pneumonia aspiration 29.56 10.02 192 191348 34348 63263134
Food craving 29.54 10.02 30 191510 1576 63295906
Psychiatric symptom 29.51 10.02 55 191485 5168 63292314
Post-traumatic stress disorder 29.30 10.02 55 191485 5196 63292286
Drug eruption 29.30 10.02 26 191514 28668 63268814
Live birth 28.96 10.02 21 191519 25609 63271873
Bradypnoea 28.89 10.02 44 191496 3506 63293976
Endolymphatic hydrops 28.84 10.02 6 191534 0 63297482
Cyanosis neonatal 28.83 10.02 17 191523 392 63297090
Feelings of worthlessness 28.81 10.02 16 191524 328 63297154
Derealisation 28.73 10.02 26 191514 1182 63296300
Impaired driving ability 28.68 10.02 50 191490 4461 63293021
Skin necrosis 28.68 10.02 4 191536 13946 63283536
Neuropathy peripheral 28.53 10.02 213 191327 113454 63184028
Inappropriate antidiuretic hormone secretion 28.49 10.02 107 191433 15355 63282127
Exposure via breast milk 28.35 10.02 33 191507 2024 63295458
False positive investigation result 28.32 10.02 20 191520 633 63296849
Bone marrow failure 28.20 10.02 28 191512 29262 63268220
Depressed level of consciousness 28.20 10.02 299 191241 61779 63235703
Emotional poverty 28.17 10.02 16 191524 343 63297139
Vasoplegia syndrome 28.14 10.02 30 191510 1669 63295813
Infantile apnoea 28.11 10.02 24 191516 1009 63296473
Ventricular tachycardia 27.94 10.02 127 191413 19852 63277630
Congenital absence of bile ducts 27.69 10.02 8 191532 23 63297459
Paradoxical drug reaction 27.68 10.02 47 191493 4105 63293377
Congestive cardiomyopathy 27.60 10.02 59 191481 6123 63291359
Liver injury 27.55 10.02 92 191448 60428 63237054
Cardiotoxicity 27.29 10.02 71 191469 8367 63289115
Injection site pain 27.26 10.02 255 191285 129545 63167937
Adverse event 27.25 10.02 108 191432 67451 63230031
Tongue biting 27.25 10.02 28 191512 1492 63295990
Tic 27.25 10.02 28 191512 1492 63295990
Adulterated product 27.23 10.02 14 191526 244 63297238
Antipsychotic drug level increased 27.14 10.02 42 191498 3393 63294089
White blood cell count decreased 26.82 10.02 279 191261 138825 63158657
Antidepressant discontinuation syndrome 26.79 10.02 9 191531 48 63297434
Stiff person syndrome 26.60 10.02 15 191525 317 63297165
Abnormal weight gain 26.30 10.02 30 191510 1800 63295682
Delirium 26.11 10.02 250 191290 50291 63247191
Tenosynovitis 26.03 10.02 5 191535 13790 63283692
Product tampering 25.91 10.02 16 191524 402 63297080
Drug level increased 25.69 10.02 136 191404 22600 63274882
Encephalopathy neonatal 25.68 10.02 7 191533 15 63297467
Rhabdomyolysis 25.55 10.02 223 191317 43728 63253754
Erythema dyschromicum perstans 25.50 10.02 9 191531 57 63297425
Vision blurred 25.36 10.02 404 191136 91520 63205962
Pyramidal tract syndrome 25.35 10.02 15 191525 348 63297134
Victim of sexual abuse 25.24 10.02 19 191521 665 63296817
Blood cholesterol increased 25.16 10.02 173 191367 93859 63203623
Concussion 25.14 10.02 73 191467 9171 63288311
Orthostatic intolerance 25.07 10.02 24 191516 1173 63296309
Obstructive airways disorder 24.91 10.02 126 191414 20573 63276909
Frustration tolerance decreased 24.90 10.02 61 191479 6927 63290555
Allergy to venom 24.70 10.02 6 191534 6 63297476
Iodine allergy 24.62 10.02 20 191520 784 63296698
Hospitalisation 24.55 10.02 153 191387 84928 63212554
Fall 24.38 10.02 1431 190109 390903 62906579
Suspected suicide 24.11 10.02 58 191482 6510 63290972
ECG P wave inverted 24.03 10.02 5 191535 0 63297482
Tension 23.95 10.02 38 191502 3137 63294345
Persistent depressive disorder 23.81 10.02 22 191518 1028 63296454
Middle insomnia 23.72 10.02 88 191452 12555 63284927
Coma acidotic 23.55 10.02 10 191530 110 63297372
Septic shock 23.53 10.02 112 191428 66517 63230965
Incoherent 23.50 10.02 46 191494 4484 63292998
Schizophreniform disorder 23.49 10.02 9 191531 74 63297408
Feeling jittery 23.26 10.02 91 191449 13312 63284170
Starvation ketoacidosis 23.18 10.02 9 191531 77 63297405
Pulse abnormal 23.17 10.02 32 191508 2332 63295150
Obsessive thoughts 23.12 10.02 17 191523 574 63296908
Multiple sclerosis 23.06 10.02 139 191401 24233 63273249
Femur fracture 23.00 10.02 58 191482 41698 63255784
Social anxiety disorder 22.98 10.02 15 191525 416 63297066
Amenorrhoea 22.95 10.02 74 191466 9840 63287642
Osteoporosis 22.91 10.02 92 191448 57246 63240236
Electric shock sensation 22.87 10.02 19 191521 769 63296713
Hyperacusis 22.84 10.02 30 191510 2083 63295399
Therapy non-responder 22.68 10.02 135 191405 75766 63221716
Feeling drunk 22.64 10.02 43 191497 4099 63293383
Helplessness 22.39 10.02 13 191527 291 63297191
Affective disorder 22.27 10.02 54 191486 6092 63291390
Narcolepsy 22.24 10.02 24 191516 1354 63296128
Cholestatic liver injury 22.16 10.02 33 191507 2577 63294905
Neonatal hypotension 22.14 10.02 10 191530 129 63297353
Attention deficit hyperactivity disorder 22.09 10.02 36 191504 3040 63294442
HELLP syndrome 21.99 10.02 21 191519 1023 63296459
Congenital pulmonary hypertension 21.99 10.02 8 191532 56 63297426
Osteoarthritis 21.91 10.02 183 191357 95160 63202322
Eosinophilic pustular folliculitis 21.90 10.02 7 191533 31 63297451
Congenital multiplex arthrogryposis 21.90 10.02 7 191533 31 63297451
Dyssomnia 21.90 10.02 7 191533 31 63297451
Creatinine renal clearance decreased 21.73 10.02 11 191529 16297 63281185
Dysphoria 21.72 10.02 47 191493 4919 63292563
Forced expiratory volume decreased 21.71 10.02 47 191493 4921 63292561
Dependence 21.70 10.02 29 191511 2048 63295434
Unemployment 21.69 10.02 5 191535 3 63297479
Drug use disorder 21.60 10.02 47 191493 4937 63292545
Alcoholism 21.52 10.02 27 191513 1791 63295691
Cytomegalovirus infection 21.38 10.02 19 191521 20933 63276549
Consciousness fluctuating 21.29 10.02 19 191521 848 63296634
Injection site erythema 21.28 10.02 155 191385 83019 63214463
Lip dry 21.27 10.02 10 191530 15460 63282022
Plasma cell myeloma 21.26 10.02 48 191492 35857 63261625
Musculoskeletal pain 21.26 10.02 177 191363 92100 63205382
Antisocial behaviour 21.24 10.02 14 191526 395 63297087
Amyloid arthropathy 21.16 10.02 16 191524 564 63296918
Abulia 21.15 10.02 15 191525 478 63297004
Anhedonia 21.10 10.02 77 191463 10897 63286585
Metabolic syndrome 21.10 10.02 25 191515 1563 63295919
Neonatal disorder 21.09 10.02 16 191524 567 63296915
Trunk injury 20.83 10.02 6 191534 17 63297465
Grip strength decreased 20.67 10.02 22 191518 22265 63275217
Acquired amegakaryocytic thrombocytopenia 20.58 10.02 6 191534 18 63297464
Blood catecholamines increased 20.58 10.02 6 191534 18 63297464
Claustrophobia 20.55 10.02 20 191520 998 63296484
Macular degeneration 20.51 10.02 26 191514 24350 63273132
Oedema peripheral 20.45 10.02 426 191114 189085 63108397
Hypertonia 20.41 10.02 44 191496 4593 63292889
Affect lability 20.41 10.02 77 191463 11074 63286408
Unresponsive to stimuli 20.40 10.02 173 191367 33643 63263839
Nodule 20.35 10.02 20 191520 21006 63276476
Soft tissue injury 20.30 10.02 25 191515 1627 63295855
Skin maceration 20.29 10.02 7 191533 41 63297441
Slow speech 20.20 10.02 24 191516 1505 63295977
Hypercalcaemia 20.12 10.02 34 191506 28288 63269194
Eye movement disorder 20.09 10.02 47 191493 5181 63292301
Lactic acidosis 20.08 10.02 190 191350 38097 63259385
Head discomfort 20.06 10.02 87 191453 13328 63284154
Skin ulcer 19.89 10.02 65 191475 42980 63254502
Erythema 19.88 10.02 392 191148 175359 63122123
Ascites 19.88 10.02 60 191480 40668 63256814
Bradyphrenia 19.83 10.02 56 191484 6924 63290558
Transient psychosis 19.61 10.02 7 191533 46 63297436
Electrocardiogram ST-T segment abnormal 19.52 10.02 12 191528 299 63297183
Creutzfeldt-Jakob disease 19.52 10.02 10 191530 173 63297309
CYP3A4 polymorphism 19.51 10.02 8 191532 80 63297402
Hepatic function abnormal 19.38 10.02 53 191487 37089 63260393
Upper gastrointestinal haemorrhage 19.35 10.02 17 191523 18835 63278647
Disturbance in sexual arousal 19.33 10.02 9 191531 125 63297357
Bundle branch block right 19.28 10.02 45 191495 4953 63292529
Ventricular hypokinesia 19.23 10.02 43 191497 4601 63292881
Neonatal oversedation 19.23 10.02 4 191536 0 63297482
Atypical fibroxanthoma 19.23 10.02 4 191536 0 63297482
Respiratory acidosis 19.20 10.02 54 191486 6661 63290821
Sciatic nerve neuropathy 19.14 10.02 13 191527 386 63297096
Hyperbilirubinaemia neonatal 19.14 10.02 13 191527 386 63297096
Conversion disorder 19.00 10.02 25 191515 1739 63295743
Feeling guilty 18.93 10.02 15 191525 567 63296915
Dopamine transporter scintigraphy abnormal 18.92 10.02 8 191532 87 63297395
Respiratory tract infection 18.92 10.02 63 191477 41420 63256062
Violence-related symptom 18.88 10.02 13 191527 395 63297087
Intestinal strangulation 18.84 10.02 8 191532 88 63297394
Pulmonary pain 18.79 10.02 36 191504 3454 63294028
Sluggishness 18.78 10.02 46 191494 5223 63292259
Impaired work ability 18.71 10.02 103 191437 17372 63280110
Dystonia 18.70 10.02 87 191453 13732 63283750
Urticaria 18.69 10.02 370 191170 165432 63132050
Poor weight gain neonatal 18.68 10.02 8 191532 90 63297392
Pre-existing condition improved 18.60 10.02 61 191479 8183 63289299
Bacteraemia 18.60 10.02 15 191525 17333 63280149
Cytokine release syndrome 18.56 10.02 10 191530 14304 63283178
Stress 18.45 10.02 295 191245 66872 63230610
Trismus 18.42 10.02 38 191502 3847 63293635
Cardiomyopathy 18.40 10.02 103 191437 17481 63280001
Neurodegenerative disorder 18.38 10.02 12 191528 333 63297149
Depression suicidal 18.36 10.02 25 191515 1798 63295684
Arthritis 18.28 10.02 243 191297 115678 63181804
Acute hepatitis B 18.25 10.02 12 191528 337 63297145
Right ventricular failure 18.25 10.02 15 191525 17173 63280309
Hyperkalaemia 18.05 10.02 93 191447 54110 63243372
Opisthotonus 18.04 10.02 12 191528 344 63297138
Blood creatine phosphokinase increased 18.00 10.02 155 191385 30275 63267207
Anticonvulsant drug level above therapeutic 17.93 10.02 14 191526 518 63296964
Blood triglycerides increased 17.92 10.02 80 191460 12408 63285074
Palmar-plantar erythrodysaesthesia syndrome 17.90 10.02 26 191514 22989 63274493
Transfusion 17.81 10.02 12 191528 15205 63282277
Basal cell carcinoma 17.76 10.02 36 191504 27955 63269527
Floppy infant 17.72 10.02 8 191532 103 63297379
Anuria 17.71 10.02 80 191460 12471 63285011
Cerebral vasoconstriction 17.70 10.02 20 191520 1188 63296294
Mucosal inflammation 17.69 10.02 77 191463 46851 63250631
Sinus rhythm 17.62 10.02 17 191523 839 63296643
Cerebral infarction 17.61 10.02 28 191512 23865 63273617
Fear 17.60 10.02 94 191446 15672 63281810
Premature delivery 17.51 10.02 41 191499 30240 63267242
COVID-19 17.51 10.02 238 191302 112865 63184617
Drug specific antibody 17.51 10.02 28 191512 2327 63295155
Headache 17.32 10.02 2172 189368 631069 62666413
Emotional distress 17.31 10.02 162 191378 32387 63265095
Post-traumatic neck syndrome 17.29 10.02 26 191514 2048 63295434
Persistent left superior vena cava 17.27 10.02 6 191534 36 63297446
Psoriasis 17.26 10.02 363 191177 86594 63210888
Alcohol use 17.25 10.02 26 191514 2053 63295429
Cold agglutinins positive 17.13 10.02 6 191534 37 63297445
Facial nerve disorder 17.10 10.02 14 191526 555 63296927
Loose tooth 17.05 10.02 34 191506 3360 63294122
Neutrophil count decreased 17.02 10.02 100 191440 56306 63241176
Platelet aggregation abnormal 17.00 10.02 4 191536 3 63297479
Tubulointerstitial nephritis 16.99 10.02 21 191519 19882 63277600
Cystic lymphangioma 16.91 10.02 5 191535 16 63297466
Psychiatric decompensation 16.89 10.02 21 191519 1380 63296102
Cytopenia 16.74 10.02 7 191533 11594 63285888
Foot deformity 16.69 10.02 37 191503 27816 63269666
Pre-eclampsia 16.66 10.02 63 191477 9070 63288412
Ataxia 16.56 10.02 90 191450 15105 63282377
Congenital uterine anomaly 16.52 10.02 8 191532 122 63297360
Fatigue 16.41 10.02 2390 189150 885638 62411844
Cholestasis 16.41 10.02 148 191392 29286 63268196
Female sexual dysfunction 16.37 10.02 6 191534 43 63297439
Poor personal hygiene 16.36 10.02 11 191529 321 63297161
Incontinence 16.31 10.02 74 191466 11558 63285924
Akinesia 16.27 10.02 22 191518 1571 63295911
Ventricular fibrillation 16.27 10.02 75 191465 11792 63285690
Inflammation 16.27 10.02 164 191376 82109 63215373
Deja vu 16.25 10.02 7 191533 80 63297402
Ulcer 16.21 10.02 34 191506 26073 63271409
Cushingoid 16.17 10.02 3 191537 8482 63289000
Retinal detachment 16.10 10.02 47 191493 5922 63291560
Splenic infarction 16.04 10.02 23 191517 1736 63295746
Bradycardia 15.96 10.02 310 191230 72917 63224565
Movement disorder 15.92 10.02 116 191424 21545 63275937
Peak expiratory flow rate decreased 15.88 10.02 14 191526 615 63296867
Wound infection 15.87 10.02 25 191515 21385 63276097
Fluid retention 15.87 10.02 110 191430 59576 63237906
Acute myeloid leukaemia 15.82 10.02 17 191523 17130 63280352
Purging 15.80 10.02 6 191534 48 63297434
Colitis 15.75 10.02 84 191456 48444 63249038
Sternal fracture 15.67 10.02 26 191514 2228 63295254
Balance disorder 15.66 10.02 349 191191 84073 63213409
Blood lactic acid increased 15.60 10.02 52 191488 7034 63290448
Tremor neonatal 15.53 10.02 8 191532 140 63297342
Neurotoxicity 15.50 10.02 17 191523 16973 63280509
Neoplasm progression 15.49 10.02 57 191483 36371 63261111
Troponin abnormal 15.49 10.02 6 191534 51 63297431
Sleep talking 15.47 10.02 17 191523 979 63296503
Accidental death 15.39 10.02 24 191516 1952 63295530
Central nervous system necrosis 15.38 10.02 8 191532 143 63297339
Neonatal tachypnoea 15.33 10.02 8 191532 144 63297338
Kleptomania 15.32 10.02 5 191535 24 63297458
Device expulsion 15.27 10.02 54 191486 34868 63262614
Neurological examination abnormal 15.24 10.02 10 191530 280 63297202
Bladder trabeculation 15.19 10.02 6 191534 54 63297428
Ligament pain 15.17 10.02 9 191531 210 63297272
Blood calcium decreased 15.15 10.02 36 191504 26415 63271067
Lip and/or oral cavity cancer 15.13 10.02 16 191524 882 63296600
Therapeutic response decreased 15.10 10.02 116 191424 61409 63236073
Activation syndrome 15.05 10.02 9 191531 213 63297269
Rash pruritic 15.03 10.02 112 191428 59687 63237795
Epstein-Barr virus infection 15.01 10.02 3 191537 8047 63289435
Adjustment disorder with depressed mood 14.98 10.02 6 191534 10198 63287284
Abnormal sleep-related event 14.93 10.02 15 191525 778 63296704
Nephropathy toxic 14.88 10.02 5 191535 9474 63288008
Hypokinesia 14.83 10.02 82 191458 13854 63283628
Increased appetite 14.82 10.02 63 191477 9567 63287915
Fibromyalgia 14.80 10.02 163 191377 80257 63217225
Arrhythmia 14.74 10.02 178 191362 37962 63259520
Brief psychotic disorder with marked stressors 14.72 10.02 6 191534 59 63297423
Pancreatic enlargement 14.72 10.02 6 191534 59 63297423
Multiple allergies 14.71 10.02 12 191528 13790 63283692
Bipolar I disorder 14.70 10.02 23 191517 1876 63295606
Foetal alcohol syndrome 14.68 10.02 5 191535 28 63297454
Ideas of reference 14.68 10.02 7 191533 103 63297379
Peripheral venous disease 14.66 10.02 15 191525 15462 63282020
Lung diffusion test decreased 14.63 10.02 14 191526 684 63296798
Urinary tract infection 14.61 10.02 651 190889 264033 63033449
Product monitoring error 14.60 10.02 38 191502 4478 63293004
Marital problem 14.58 10.02 8 191532 160 63297322
Anal atresia 14.57 10.02 11 191529 387 63297095
Proteinuria 14.53 10.02 22 191518 19123 63278359
Exposure via ingestion 14.44 10.02 29 191511 2880 63294602
Upper respiratory tract infection 14.43 10.02 168 191372 81879 63215603
Immature respiratory system 14.42 10.02 3 191537 0 63297482
Hypnopompic hallucination 14.38 10.02 6 191534 63 63297419
Postmortem blood drug level increased 14.37 10.02 13 191527 591 63296891
Drug abuser 14.34 10.02 29 191511 2894 63294588
Radius fracture 14.32 10.02 33 191507 3602 63293880
Diverticulitis 14.25 10.02 66 191474 39491 63257991
Apallic syndrome 14.24 10.02 14 191526 707 63296775
Liver disorder 14.24 10.02 99 191441 53588 63243894
Liver function test increased 14.17 10.02 51 191489 32760 63264722
Abdominal pain upper 14.16 10.02 495 191045 205949 63091533
Foetal arrhythmia 14.11 10.02 8 191532 171 63297311
Somnolence neonatal 14.10 10.02 7 191533 113 63297369
Persecutory delusion 14.07 10.02 28 191512 2762 63294720
Cogwheel rigidity 14.07 10.02 23 191517 1947 63295535
Herbal interaction 13.99 10.02 7 191533 115 63297367
Pulmonary artery stenosis congenital 13.97 10.02 9 191531 244 63297238
Total lung capacity increased 13.91 10.02 25 191515 2285 63295197
Hyperglycaemia 13.90 10.02 190 191350 41677 63255805
Right ventricular systolic pressure decreased 13.87 10.02 5 191535 34 63297448
Language disorder 13.81 10.02 24 191516 2136 63295346
Regressive behaviour 13.78 10.02 8 191532 179 63297303
Barotrauma 13.74 10.02 8 191532 180 63297302
Asthma 13.73 10.02 492 191048 127069 63170413
Female genital tract fistula 13.72 10.02 3 191537 7556 63289926
Contusion 13.72 10.02 346 191194 149698 63147784
Tumour lysis syndrome 13.67 10.02 5 191535 8985 63288497
Cough 13.62 10.02 733 190807 292010 63005472
Hereditary non-polyposis colorectal cancer syndrome 13.62 10.02 7 191533 122 63297360
Drug withdrawal convulsions 13.53 10.02 19 191521 1406 63296076
Therapeutic response unexpected 13.53 10.02 100 191440 18659 63278823
Blood pressure increased 13.49 10.02 608 190932 161454 63136028
Divorced 13.48 10.02 4 191536 13 63297469
Aplastic anaemia 13.44 10.02 6 191534 9563 63287919
Haemangioma 13.42 10.02 27 191513 2685 63294797
Glassy eyes 13.38 10.02 6 191534 76 63297406
Decreased interest 13.33 10.02 30 191510 3224 63294258
Tympanic membrane disorder 13.32 10.02 8 191532 191 63297291
Exposure during pregnancy 13.26 10.02 585 190955 154962 63142520
Thrombosis 13.25 10.02 128 191412 64627 63232855
Neurological symptom 13.24 10.02 43 191497 5740 63291742
Focal dyscognitive seizures 13.18 10.02 28 191512 2893 63294589
Pneumonitis 13.15 10.02 58 191482 35164 63262318
Drug level above therapeutic 13.12 10.02 38 191502 4767 63292715
Merycism 13.11 10.02 9 191531 272 63297210
Sleep apnoea syndrome 13.07 10.02 140 191400 28993 63268489
Neuropsychiatric syndrome 13.06 10.02 5 191535 41 63297441
Respiratory tract congestion 13.05 10.02 21 191519 17811 63279671
Electroencephalogram abnormal 13.02 10.02 32 191508 3640 63293842
Jaundice neonatal 13.02 10.02 15 191525 910 63296572
Maternal exposure during breast feeding 13.02 10.02 35 191505 4206 63293276
Cerebral haematoma 12.96 10.02 32 191508 3651 63293831
Cardiac valve disease 12.96 10.02 35 191505 4217 63293265
Haemophagocytic lymphohistiocytosis 12.96 10.02 8 191532 10619 63286863
Muscle tone disorder 12.89 10.02 7 191533 137 63297345
Product formulation issue 12.89 10.02 12 191528 566 63296916
Foetal growth restriction 12.88 10.02 51 191489 7502 63289980
Flight of ideas 12.87 10.02 11 191529 463 63297019
Coarctation of the aorta 12.87 10.02 12 191528 567 63296915
Urinary retention 12.86 10.02 144 191396 30157 63267325
Mechanical urticaria 12.83 10.02 11 191529 465 63297017
Second primary malignancy 12.83 10.02 4 191536 7949 63289533
Oropharyngeal pain 12.82 10.02 204 191336 94283 63203199
Respiratory failure 12.81 10.02 223 191317 101635 63195847
Autoimmune disorder 12.78 10.02 20 191520 17157 63280325
Nonspecific reaction 12.78 10.02 24 191516 2268 63295214
Brain contusion 12.77 10.02 12 191528 573 63296909
Respiratory rate decreased 12.74 10.02 31 191509 3504 63293978
Acute kidney injury 12.74 10.02 657 190883 262758 63034724
Fear of injection 12.69 10.02 3 191537 7161 63290321
Status epilepticus 12.62 10.02 84 191456 15149 63282333
Circulatory collapse 12.59 10.02 111 191429 21827 63275655
Impatience 12.55 10.02 10 191530 381 63297101
Anaemia of pregnancy 12.54 10.02 6 191534 89 63297393
Metastases to bone 12.53 10.02 28 191512 20991 63276491
Distributive shock 12.49 10.02 18 191522 1365 63296117
Delusional disorder, unspecified type 12.42 10.02 10 191530 387 63297095
Labour complication 12.41 10.02 7 191533 148 63297334
Antidepressant drug level decreased 12.35 10.02 3 191537 3 63297479
Obsessive rumination 12.35 10.02 3 191537 3 63297479
Intestinal intraepithelial lymphocytes increased 12.35 10.02 3 191537 3 63297479
Anxiety disorder due to a general medical condition 12.35 10.02 3 191537 3 63297479
Heart rate increased 12.34 10.02 372 191168 93866 63203616
Gun shot wound 12.33 10.02 7 191533 150 63297332
Adrenal insufficiency 12.28 10.02 22 191518 17893 63279589
Perinatal depression 12.27 10.02 13 191527 718 63296764
Cardiac failure 12.25 10.02 192 191348 88950 63208532
Bladder dilatation 12.23 10.02 14 191526 843 63296639
Blood bilirubin increased 12.21 10.02 64 191476 37076 63260406
Lupus-like syndrome 12.17 10.02 17 191523 15278 63282204
Housebound 12.13 10.02 8 191532 226 63297256
Exposure via transplant 12.12 10.02 4 191536 20 63297462
Amniotic fluid volume increased 12.08 10.02 7 191533 156 63297326
Blood urea increased 12.07 10.02 40 191500 26339 63271143
Arachnoid cyst 12.07 10.02 8 191532 228 63297254
Polydactyly 12.03 10.02 9 191531 312 63297170
CYP2D6 polymorphism 12.02 10.02 5 191535 52 63297430
Parachute mitral valve 12.02 10.02 6 191534 98 63297384
Hepatocellular injury 12.02 10.02 131 191409 27250 63270232
Parkinsonian gait 12.01 10.02 11 191529 508 63296974
Myelodysplastic syndrome 12.01 10.02 20 191520 16734 63280748
Cataract 12.01 10.02 112 191428 56941 63240541
Skin disorder 12.01 10.02 47 191493 29460 63268022
Transplant rejection 11.96 10.02 9 191531 10771 63286711
Hypersexuality 11.96 10.02 11 191529 511 63296971
Acute respiratory distress syndrome 11.95 10.02 116 191424 23418 63274064
Feeling hot 11.95 10.02 216 191324 50138 63247344
Ventricular extrasystoles 11.92 10.02 68 191472 11619 63285863
Hepatic necrosis 11.88 10.02 41 191499 5646 63291836
Substance use 11.87 10.02 11 191529 516 63296966
Eye pruritus 11.86 10.02 24 191516 18647 63278835
Flat affect 11.84 10.02 18 191522 1432 63296050
Hypertonia neonatal 11.82 10.02 8 191532 236 63297246
Formication 11.78 10.02 34 191506 4257 63293225
Injection site bruising 11.76 10.02 76 191464 41834 63255648
Device related infection 11.75 10.02 34 191506 23358 63274124
Feeling of body temperature change 11.74 10.02 37 191503 4860 63292622
Pulmonary vein occlusion 11.65 10.02 6 191534 105 63297377
Urosepsis 11.60 10.02 24 191516 18500 63278982
Photophobia 11.59 10.02 92 191448 17543 63279939
Chronic sinusitis 11.55 10.02 13 191527 12830 63284652
Sleep paralysis 11.55 10.02 12 191528 648 63296834
Ultrasound abdomen abnormal 11.54 10.02 5 191535 58 63297424
Morbihan disease 11.52 10.02 4 191536 24 63297458
Ocular hypertension 11.49 10.02 15 191525 1035 63296447
Respiration abnormal 11.49 10.02 44 191496 6373 63291109
Thrombotic microangiopathy 11.49 10.02 9 191531 10552 63286930
Cartilage injury 11.40 10.02 21 191519 1956 63295526
Colitis ischaemic 11.39 10.02 63 191477 10645 63286837
Alcohol abuse 11.39 10.02 22 191518 2124 63295358
Hypocalcaemia 11.37 10.02 53 191487 31660 63265822
Intestinal anastomosis complication 11.31 10.02 8 191532 254 63297228
Breech presentation 11.25 10.02 16 191524 1198 63296284
Pleural rub 11.24 10.02 5 191535 62 63297420
Throat irritation 11.22 10.02 67 191473 37580 63259902
Haematocrit decreased 11.21 10.02 71 191469 39269 63258213
Dialysis 11.20 10.02 9 191531 10418 63287064
Enthesopathy 11.19 10.02 6 191534 8608 63288874
Congenital naevus 11.16 10.02 7 191533 181 63297301
No adverse event 11.16 10.02 76 191464 41329 63256153
Congenital pharyngeal anomaly 11.14 10.02 3 191537 6 63297476
Platelet aggregation decreased 11.12 10.02 4 191536 27 63297455
Cellulitis 11.10 10.02 177 191363 81781 63215701
Haemodynamic instability 11.10 10.02 56 191484 9134 63288348
Head injury 11.09 10.02 129 191411 27267 63270215
Chest discomfort 11.04 10.02 250 191290 109719 63187763
Talipes 11.03 10.02 18 191522 1522 63295960
Prescription form tampering 11.00 10.02 11 191529 567 63296915
Peritonitis 10.94 10.02 22 191518 17132 63280350
Bone density decreased 10.89 10.02 17 191523 14595 63282887
Gambling disorder 10.88 10.02 16 191524 1236 63296246
Dreamy state 10.87 10.02 4 191536 29 63297453
Nail disorder 10.83 10.02 14 191526 13001 63284481
Left ventricular hypertrophy 10.82 10.02 38 191502 5277 63292205
Hypnagogic hallucination 10.79 10.02 7 191533 192 63297290
Hyperemesis gravidarum 10.78 10.02 11 191529 581 63296901
Low birth weight baby 10.78 10.02 4 191536 7125 63290357
Dissociative amnesia 10.76 10.02 4 191536 30 63297452
Osteonecrosis of jaw 10.74 10.02 62 191478 35061 63262421
Pathogen resistance 10.72 10.02 3 191537 6395 63291087
Amphetamines positive 10.70 10.02 7 191533 195 63297287
Toxicologic test abnormal 10.67 10.02 12 191528 709 63296773
Therapy interrupted 10.63 10.02 56 191484 32399 63265083
Skin texture abnormal 10.61 10.02 10 191530 479 63297003
Alcohol poisoning 10.58 10.02 20 191520 1899 63295583
Hypoalbuminaemia 10.56 10.02 12 191528 11793 63285689
Hypoglycaemic seizure 10.56 10.02 10 191530 482 63297000
Haemolytic anaemia 10.55 10.02 9 191531 10116 63287366
Xanthopsia 10.54 10.02 7 191533 200 63297282
Meningism 10.51 10.02 10 191530 485 63296997
Portal fibrosis 10.51 10.02 8 191532 285 63297197
Bronchiectasis 10.50 10.02 84 191456 16058 63281424
Hypervolaemia 10.48 10.02 47 191493 28366 63269116
Pancreatic failure 10.47 10.02 14 191526 989 63296493
Atrophic vulvovaginitis 10.47 10.02 19 191521 1749 63295733
Device difficult to use 10.41 10.02 14 191526 12782 63284700
Attention-seeking behaviour 10.40 10.02 5 191535 75 63297407
Agoraphobia 10.37 10.02 9 191531 387 63297095
Ear infection 10.37 10.02 70 191470 38143 63259339
Hereditary ataxia 10.32 10.02 4 191536 34 63297448
Bronchospasm 10.31 10.02 23 191517 17257 63280225
Subacute kidney injury 10.29 10.02 3 191537 9 63297473
Crush injury 10.29 10.02 3 191537 9 63297473
Pseudophaeochromocytoma 10.28 10.02 5 191535 77 63297405
Staring 10.27 10.02 18 191522 1612 63295870
Foetal heart rate deceleration abnormality 10.27 10.02 10 191530 499 63296983
Alpha 2 globulin increased 10.27 10.02 6 191534 136 63297346
Waxy flexibility 10.27 10.02 6 191534 136 63297346
Musculoskeletal chest pain 10.26 10.02 103 191437 20980 63276502
Foaming at mouth 10.25 10.02 15 191525 1153 63296329
Communication disorder 10.19 10.02 23 191517 2477 63295005
Hallucination, tactile 10.13 10.02 8 191532 301 63297181
Hyperchloraemia 10.12 10.02 12 191528 751 63296731
Muscle tightness 10.09 10.02 66 191474 11834 63285648
Breast cancer stage II 10.08 10.02 7 191533 8729 63288753
Vertebral lesion 10.04 10.02 11 191529 631 63296851

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 847.99 10.81 537 77263 19396 34859735
Completed suicide 777.41 10.81 1022 76778 97146 34781985
Intentional overdose 515.72 10.81 558 77242 43116 34836015
Suicidal ideation 505.09 10.81 532 77268 39856 34839275
Suicide attempt 504.83 10.81 524 77276 38592 34840539
Drug withdrawal syndrome 467.88 10.81 373 77427 19461 34859670
Toxicity to various agents 446.56 10.81 1209 76591 199153 34679978
Overdose 301.01 10.81 641 77159 90418 34788713
Foetal exposure during pregnancy 244.34 10.81 359 77441 37742 34841389
Withdrawal syndrome 241.15 10.81 209 77591 12246 34866885
Coma 196.03 10.81 359 77441 45319 34833812
Hyperhidrosis 194.85 10.81 483 77317 75209 34803922
Drug abuse 181.24 10.81 558 77242 98538 34780593
Anxiety 175.49 10.81 553 77247 98875 34780256
Agitation 166.80 10.81 384 77416 57015 34822116
Depression 158.63 10.81 526 77274 96572 34782559
Febrile neutropenia 157.56 10.81 54 77746 136795 34742336
Mania 153.36 10.81 144 77656 9367 34869764
Respiratory disorder neonatal 152.80 10.81 74 77726 1556 34877575
Maternal exposure during pregnancy 152.54 10.81 109 77691 4809 34874322
Drug interaction 150.87 10.81 938 76862 225008 34654123
Drug withdrawal syndrome neonatal 150.00 10.81 96 77704 3523 34875608
Sedation 146.42 10.81 206 77594 20800 34858331
Nightmare 144.24 10.81 169 77631 14222 34864909
Sopor 142.94 10.81 155 77645 11981 34867150
Pneumonia 136.77 10.81 387 77413 362240 34516891
Disturbance in attention 136.23 10.81 223 77577 25722 34853409
Pyrexia 131.83 10.81 347 77453 332666 34546465
Intentional self-injury 130.24 10.81 157 77643 13614 34865517
Mydriasis 129.20 10.81 116 77684 7121 34872010
Exposure during pregnancy 128.45 10.81 127 77673 8807 34870324
Small for dates baby 121.71 10.81 87 77713 3840 34875291
Anaemia 111.80 10.81 219 77581 233116 34646015
Depressed mood 110.97 10.81 173 77627 19144 34859987
Poisoning deliberate 109.99 10.81 110 77690 7734 34871397
Selective eating disorder 107.11 10.81 60 77740 1718 34877413
Myoclonus 106.48 10.81 147 77653 14578 34864553
Restlessness 105.15 10.81 197 77603 25285 34853846
Tremor 103.07 10.81 410 77390 82177 34796954
Hypotonia neonatal 102.33 10.81 53 77747 1292 34877839
Bipolar disorder 101.74 10.81 76 77724 3593 34875538
Electrocardiogram QT prolonged 99.70 10.81 256 77544 40696 34838435
Sepsis 99.69 10.81 135 77665 166426 34712705
Hyperreflexia 97.00 10.81 70 77730 3136 34875995
Somnolence 96.21 10.81 495 77305 110621 34768510
Disease progression 94.69 10.81 62 77738 108015 34771116
Major depression 93.11 10.81 79 77721 4493 34874638
Neonatal respiratory distress syndrome 91.09 10.81 74 77726 3960 34875171
Erectile dysfunction 90.75 10.81 164 77636 20473 34858658
Cataplexy 89.90 10.81 32 77768 294 34878837
Neutropenia 89.90 10.81 131 77669 156647 34722484
Drug dependence 89.85 10.81 179 77621 24038 34855093
Irritability 86.26 10.81 178 77622 24512 34854619
Seizure 85.86 10.81 460 77340 104397 34774734
Rash 82.80 10.81 239 77561 222513 34656618
Poisoning 82.38 10.81 118 77682 12108 34867023
Atrial septal defect 81.14 10.81 91 77709 7301 34871830
Diarrhoea 79.71 10.81 525 77275 389387 34489744
Hallucination, auditory 75.91 10.81 112 77688 11805 34867326
Dyspnoea 75.65 10.81 510 77290 376272 34502859
Dyskinesia 71.82 10.81 156 77644 22257 34856874
Psychotic symptom 71.65 10.81 46 77754 1697 34877434
Acute kidney injury 70.99 10.81 394 77406 304594 34574537
Off label use 70.88 10.81 596 77204 418928 34460203
Aggression 69.79 10.81 218 77582 38746 34840385
Agitation neonatal 68.79 10.81 38 77762 1058 34878073
Delusion 68.20 10.81 110 77690 12525 34866606
Bradycardia neonatal 67.26 10.81 36 77764 940 34878191
Psychotic disorder 67.04 10.81 160 77640 24292 34854839
Malignant neoplasm progression 66.26 10.81 59 77741 87987 34791144
Sexual dysfunction 64.79 10.81 75 77725 6228 34872903
Platelet count decreased 64.77 10.81 104 77696 119613 34759518
Hallucination, visual 64.19 10.81 130 77670 17661 34861470
Talipes 62.82 10.81 44 77756 1879 34877252
Antipsychotic drug level above therapeutic 62.01 10.81 37 77763 1196 34877935
Feelings of worthlessness 61.21 10.81 24 77776 295 34878836
Insomnia 60.92 10.81 418 77382 103489 34775642
Hypertonia 58.53 10.81 59 77741 4187 34874944
Anger 58.15 10.81 99 77701 11785 34867346
Akathisia 57.19 10.81 80 77720 8029 34871102
Homicide 57.10 10.81 32 77768 917 34878214
Thrombocytopenia 57.00 10.81 169 77631 156078 34723053
Infantile apnoea 56.72 10.81 32 77768 929 34878202
Somnambulism 56.33 10.81 50 77750 3022 34876109
Infection 56.05 10.81 72 77728 90843 34788288
Death 55.83 10.81 592 77208 397457 34481674
Hypertonia neonatal 55.55 10.81 25 77775 442 34878689
Postmortem blood drug level increased 55.48 10.81 21 77779 233 34878898
Panic attack 54.89 10.81 85 77715 9347 34869784
Altered state of consciousness 54.55 10.81 142 77658 22751 34856380
Pruritus 54.41 10.81 150 77650 141831 34737300
Cough 54.33 10.81 163 77637 149977 34729154
Interstitial lung disease 53.77 10.81 40 77760 65242 34813889
Septic shock 51.83 10.81 50 77750 71784 34807347
Intentional product misuse 51.76 10.81 220 77580 45391 34833740
Parkinsonism 51.13 10.81 76 77724 8062 34871069
Restless legs syndrome 51.04 10.81 77 77723 8277 34870854
Confusional state 50.75 10.81 517 77283 143643 34735488
Renal impairment 50.27 10.81 83 77717 94430 34784701
Neuropathy peripheral 50.24 10.81 67 77733 83196 34795935
Neuroleptic malignant syndrome 49.86 10.81 118 77682 17816 34861315
Congenital megaureter 49.29 10.81 17 77783 141 34878990
Stress cardiomyopathy 49.10 10.81 39 77761 2020 34877111
Miosis 48.74 10.81 81 77719 9454 34869677
Hypomania 48.53 10.81 41 77759 2318 34876813
Neonatal tachypnoea 47.78 10.81 17 77783 156 34878975
Drug screen positive 47.54 10.81 51 77749 3892 34875239
Haemoglobin decreased 46.70 10.81 127 77673 120645 34758486
Cytomegalovirus infection 46.29 10.81 3 77797 26132 34852999
Tachycardia 45.57 10.81 334 77466 84438 34794693
Respiratory failure 45.18 10.81 110 77690 108462 34770669
Feeling jittery 45.17 10.81 50 77750 3953 34875178
Hypospadias 45.08 10.81 45 77755 3156 34875975
Erythema 44.45 10.81 81 77719 88699 34790432
Muscle rigidity 44.23 10.81 82 77718 10436 34868695
Maternal drugs affecting foetus 43.84 10.81 49 77751 3916 34875215
Feeling abnormal 43.54 10.81 265 77535 62970 34816161
Impulsive behaviour 43.29 10.81 37 77763 2125 34877006
Clonus 43.11 10.81 41 77759 2709 34876422
Psychomotor hyperactivity 42.97 10.81 77 77723 9545 34869586
Urinary retention 42.70 10.81 177 77623 36111 34843020
Antidepressant discontinuation syndrome 42.69 10.81 9 77791 4 34879127
Pancytopenia 42.34 10.81 93 77707 95064 34784067
Cardiac failure congestive 41.66 10.81 76 77724 83194 34795937
Cyanosis neonatal 41.12 10.81 18 77782 297 34878834
Stomatitis 40.56 10.81 22 77778 42492 34836639
Product used for unknown indication 40.55 10.81 26 77774 957 34878174
Antidepressant drug level increased 39.78 10.81 14 77786 124 34879007
Blood creatinine increased 38.91 10.81 97 77703 94879 34784252
Atrial fibrillation 38.66 10.81 141 77659 122252 34756879
Oedema peripheral 38.52 10.81 137 77663 119675 34759456
Bone marrow failure 38.32 10.81 9 77791 29244 34849887
Pulmonary artery stenosis 38.22 10.81 17 77783 292 34878839
Gastrointestinal haemorrhage 38.11 10.81 88 77712 88389 34790742
Abnormal behaviour 37.81 10.81 132 77668 24837 34854294
Tardive dyskinesia 37.71 10.81 55 77745 5735 34873396
Libido decreased 37.17 10.81 49 77751 4647 34874484
Cytokine release syndrome 36.75 10.81 4 77796 22873 34856258
Social anxiety disorder 36.19 10.81 17 77783 333 34878798
Persecutory delusion 35.83 10.81 36 77764 2544 34876587
Electrocardiogram QRS complex prolonged 35.59 10.81 49 77751 4845 34874286
Arthralgia 35.57 10.81 227 77573 169814 34709317
Product substitution issue 35.51 10.81 73 77727 10022 34869109
Abulia 35.47 10.81 20 77780 580 34878551
Memory impairment 35.37 10.81 190 77610 43128 34836003
Apgar score low 35.26 10.81 23 77777 872 34878259
Infusion related reaction 34.82 10.81 40 77760 53017 34826114
Rheumatoid arthritis 34.74 10.81 21 77779 38217 34840914
Inappropriate antidiuretic hormone secretion 34.47 10.81 83 77717 12670 34866461
Self-injurious ideation 34.09 10.81 29 77771 1655 34877476
Tremor neonatal 33.95 10.81 17 77783 385 34878746
Thinking abnormal 33.90 10.81 54 77746 6083 34873048
Accidental death 33.62 10.81 34 77766 2422 34876709
Obsessive-compulsive disorder 33.58 10.81 51 77749 5513 34873618
Neonatal toxicity 33.57 10.81 9 77791 27 34879104
Reduced facial expression 33.41 10.81 24 77776 1067 34878064
Alcoholism 33.39 10.81 37 77763 2928 34876203
Salivary hypersecretion 33.39 10.81 65 77735 8579 34870552
Mental impairment 33.24 10.81 72 77728 10250 34868881
Sleep apnoea syndrome 33.02 10.81 110 77690 20211 34858920
Pleural effusion 32.84 10.81 84 77716 81462 34797669
Poor weight gain neonatal 32.82 10.81 8 77792 14 34879117
Ejaculation disorder 32.76 10.81 23 77777 986 34878145
Cardio-respiratory arrest 32.73 10.81 223 77577 55050 34824081
Macrophages increased 32.64 10.81 13 77787 167 34878964
Dissociation 32.44 10.81 28 77772 1630 34877501
Sleep disorder 32.27 10.81 148 77652 31540 34847591
Neonatal disorder 31.90 10.81 21 77779 809 34878322
Apathy 31.63 10.81 56 77744 6876 34872255
Generalised tonic-clonic seizure 31.25 10.81 111 77689 21063 34858068
COVID-19 31.14 10.81 80 77720 77470 34801661
Decreased interest 31.08 10.81 32 77768 2328 34876803
White blood cell count decreased 30.76 10.81 109 77691 95336 34783795
Suicidal behaviour 30.76 10.81 26 77774 1471 34877660
Multiple organ dysfunction syndrome 30.73 10.81 79 77721 76487 34802644
Electric shock 30.64 10.81 12 77788 147 34878984
Poor quality sleep 30.58 10.81 61 77739 8195 34870936
Logorrhoea 30.35 10.81 32 77768 2394 34876737
Encephalopathy neonatal 30.30 10.81 9 77791 43 34879088
Dysphoria 29.93 10.81 31 77769 2271 34876860
Hyperthermia 29.84 10.81 70 77730 10507 34868624
International normalised ratio increased 29.65 10.81 37 77763 47290 34831841
Homicidal ideation 29.40 10.81 33 77767 2649 34876482
Paranoia 28.89 10.81 75 77725 11993 34867138
Muscle twitching 28.89 10.81 68 77732 10230 34868901
Liver disorder 28.77 10.81 19 77781 32978 34846153
Joint swelling 28.77 10.81 56 77744 59834 34819297
Disorientation 28.76 10.81 148 77652 33040 34846091
Neonatal behavioural syndrome 28.67 10.81 11 77789 127 34879004
Epilepsy 28.63 10.81 109 77691 21386 34857745
Mood altered 28.32 10.81 62 77738 8890 34870241
Nephrolithiasis 28.21 10.81 138 77662 30195 34848936
Normal pressure hydrocephalus 28.09 10.81 12 77788 186 34878945
Abnormal dreams 28.08 10.81 56 77744 7522 34871609
Implant site extravasation 28.01 10.81 15 77785 392 34878739
Disseminated intravascular coagulation 28.01 10.81 7 77793 21809 34857322
Thermophobia 27.92 10.81 9 77791 59 34879072
Extrapyramidal disorder 27.77 10.81 77 77723 12803 34866328
Mood swings 27.63 10.81 57 77743 7844 34871287
Wrong dose 27.61 10.81 17 77783 582 34878549
Micturition urgency 27.60 10.81 51 77749 6474 34872657
Coma scale abnormal 27.46 10.81 39 77761 3969 34875162
Alopecia 27.32 10.81 10 77790 24345 34854786
Chronic kidney disease 27.11 10.81 31 77769 41179 34837952
Cognitive disorder 27.01 10.81 131 77669 28562 34850569
Prostate cancer 26.99 10.81 29 77771 39620 34839511
Acoustic stimulation tests abnormal 26.71 10.81 9 77791 69 34879062
Loss of consciousness 26.47 10.81 291 77509 82376 34796755
Hepatic function abnormal 26.44 10.81 36 77764 44327 34834804
Substance abuser 26.34 10.81 10 77790 112 34879019
Pneumocystis jirovecii pneumonia 25.94 10.81 6 77794 19704 34859427
Stevens-Johnson syndrome 25.91 10.81 5 77795 18634 34860497
Enuresis 25.88 10.81 29 77771 2324 34876807
Antineutrophil cytoplasmic antibody positive 25.75 10.81 18 77782 766 34878365
Radiation inflammation 25.66 10.81 19 77781 886 34878245
Neonatal testicular torsion 25.55 10.81 5 77795 0 34879131
Depersonalisation/derealisation disorder 25.22 10.81 16 77784 578 34878553
Plasma cell myeloma 25.17 10.81 34 77766 42003 34837128
Potentiating drug interaction 25.06 10.81 42 77758 4935 34874196
Muscle mass 24.79 10.81 12 77788 252 34878879
Physical deconditioning 24.68 10.81 22 77778 1337 34877794
Toxic cardiomyopathy 24.66 10.81 12 77788 255 34878876
Electric shock sensation 24.66 10.81 10 77790 135 34878996
Spontaneous ejaculation 24.44 10.81 6 77794 11 34879120
Hepatocellular injury 24.31 10.81 106 77694 22105 34857026
Weight increased 24.30 10.81 315 77485 92718 34786413
Renal failure 23.97 10.81 181 77619 130376 34748755
Pneumonitis 23.94 10.81 24 77776 33854 34845277
Anaphylactic reaction 23.86 10.81 22 77778 32279 34846852
Eosinophilic myocarditis 23.76 10.81 15 77785 537 34878594
Neonatal respiratory failure 23.76 10.81 13 77787 355 34878776
Cerebral infarction 23.68 10.81 16 77784 27439 34851692
Priapism 23.64 10.81 41 77759 4953 34874178
Multiple drug therapy 23.62 10.81 14 77786 447 34878684
Splenomegaly 23.40 10.81 3 77797 15114 34864017
Premature baby 23.28 10.81 96 77704 19537 34859594
Pyramidal tract syndrome 23.26 10.81 11 77789 219 34878912
Foetal malnutrition 23.23 10.81 8 77792 66 34879065
Head circumference abnormal 22.98 10.81 7 77793 37 34879094
Male orgasmic disorder 22.93 10.81 9 77791 111 34879020
Blood bilirubin increased 22.90 10.81 31 77769 38265 34840866
Arachnoid cyst 22.81 10.81 11 77789 229 34878902
Testicular atrophy 22.80 10.81 15 77785 577 34878554
Pulmonary contusion 22.72 10.81 8 77792 71 34879060
Pressure of speech 22.69 10.81 14 77786 481 34878650
Phaeochromocytoma malignant 22.62 10.81 8 77792 72 34879059
Kidney duplex 22.51 10.81 13 77787 395 34878736
Euphoric mood 22.50 10.81 43 77757 5598 34873533
Blood ethanol increased 22.49 10.81 14 77786 489 34878642
Mucosal inflammation 22.36 10.81 32 77768 38590 34840541
Product residue present 22.27 10.81 29 77771 2717 34876414
External auditory canal atresia 22.21 10.81 10 77790 177 34878954
Iris coloboma 22.14 10.81 6 77794 19 34879112
Retinal coloboma 21.91 10.81 6 77794 20 34879111
Food aversion 21.90 10.81 13 77787 416 34878715
Rhabdomyolysis 21.84 10.81 240 77560 67923 34811208
Tachycardia foetal 21.82 10.81 12 77788 331 34878800
Fall 21.67 10.81 598 77202 202287 34676844
Renal aplasia 21.53 10.81 16 77784 750 34878381
Myelosuppression 21.45 10.81 8 77792 19257 34859874
Personality disorder 21.40 10.81 19 77781 1149 34877982
Synovitis 21.28 10.81 3 77797 14063 34865068
Hangover 21.07 10.81 18 77782 1033 34878098
Thrombosis 21.07 10.81 51 77749 50407 34828724
Coagulation disorder neonatal 21.06 10.81 6 77794 24 34879107
Hypervigilance 21.04 10.81 9 77791 140 34878991
Myocardial fibrosis 20.99 10.81 19 77781 1178 34877953
Tumour lysis syndrome 20.90 10.81 6 77794 17053 34862078
Schizophrenia 20.89 10.81 54 77746 8612 34870519
Dissociative disorder 20.83 10.81 13 77787 456 34878675
Electrocardiogram QT shortened 20.76 10.81 9 77791 145 34878986
Histamine level increased 20.74 10.81 7 77793 54 34879077
Microcephaly 20.72 10.81 16 77784 795 34878336
Amnesia 20.66 10.81 115 77685 26448 34852683
Pulmonary pain 20.63 10.81 19 77781 1205 34877926
Loose associations 20.62 10.81 7 77793 55 34879076
Foetal hypokinesia 20.56 10.81 12 77788 372 34878759
Acute myocardial infarction 20.36 10.81 57 77743 53662 34825469
Lymphadenopathy 20.30 10.81 20 77780 28443 34850688
Rash maculo-papular 20.28 10.81 20 77780 28431 34850700
Urticaria 20.25 10.81 71 77729 62306 34816825
Bronchopulmonary aspergillosis 20.24 10.81 4 77796 14655 34864476
Condition aggravated 20.10 10.81 565 77235 191631 34687500
External ear disorder 19.98 10.81 6 77794 30 34879101
Gun shot wound 19.97 10.81 18 77782 1110 34878021
Forearm fracture 19.93 10.81 8 77792 105 34879026
Tubulointerstitial nephritis 19.87 10.81 11 77789 21013 34858118
Tearfulness 19.84 10.81 27 77773 2640 34876491
Neonatal respiratory distress 19.82 10.81 14 77786 606 34878525
Hypoxia 19.76 10.81 60 77740 55035 34824096
Hypokalaemia 19.75 10.81 65 77735 58149 34820982
Gastric infection 19.75 10.81 19 77781 1273 34877858
Poor sucking reflex 19.73 10.81 11 77789 312 34878819
Haematoma 19.43 10.81 17 77783 25588 34853543
Violence-related symptom 19.25 10.81 13 77787 523 34878608
Loss of libido 19.23 10.81 26 77774 2526 34876605
Contraindicated product administered 19.23 10.81 12 77788 21469 34857662
Penoscrotal fusion 19.17 10.81 5 77795 13 34879118
Persistent depressive disorder 19.17 10.81 11 77789 330 34878801
Cardiac failure 18.95 10.81 122 77678 91126 34788005
Neutrophil count decreased 18.80 10.81 55 77745 51049 34828082
Metabolic syndrome 18.79 10.81 21 77779 1678 34877453
Visual evoked potentials abnormal 18.71 10.81 7 77793 75 34879056
Hyperkalaemia 18.71 10.81 85 77715 69304 34809827
Mental disorder 18.53 10.81 75 77725 15134 34863997
Bradykinesia 18.48 10.81 32 77768 3861 34875270
Bradyphrenia 18.43 10.81 36 77764 4762 34874369
Bruxism 18.43 10.81 21 77779 1714 34877417
Foaming at mouth 18.36 10.81 15 77785 809 34878322
Haematuria 18.33 10.81 54 77746 50012 34829119
Ejaculation delayed 18.31 10.81 10 77790 272 34878859
Neoplasm progression 18.26 10.81 15 77785 23285 34855846
Myelodysplastic syndrome 18.23 10.81 10 77790 19198 34859933
Dyskinesia neonatal 18.21 10.81 4 77796 3 34879128
Ascites 17.96 10.81 49 77751 46522 34832609
Sleep-related eating disorder 17.95 10.81 10 77790 283 34878848
Gastrointestinal hypermotility 17.95 10.81 8 77792 138 34878993
C-reactive protein increased 17.95 10.81 61 77739 54037 34825094
Patent ductus arteriosus 17.82 10.81 29 77771 3325 34875806
Oedema 17.73 10.81 48 77752 45693 34833438
Drug screen false positive 17.63 10.81 14 77786 725 34878406
Sinus tachycardia 17.61 10.81 81 77719 17279 34861852
Upper respiratory tract infection 17.59 10.81 29 77771 33030 34846101
Exposure via breast milk 17.52 10.81 22 77778 1988 34877143
Cerebellar syndrome 17.50 10.81 24 77776 2364 34876767
Suspected suicide 17.49 10.81 35 77765 4713 34874418
Emotional disorder 17.42 10.81 39 77761 5677 34873454
Decreased appetite 17.39 10.81 263 77537 166129 34713002
Catatonia 17.27 10.81 36 77764 4989 34874142
Affective disorder 17.10 10.81 33 77767 4327 34874804
Palmar-plantar erythrodysaesthesia syndrome 17.05 10.81 8 77792 16787 34862344
Paraesthesia 17.05 10.81 218 77582 63954 34815177
Hospitalisation 17.01 10.81 67 77733 56835 34822296
Rebound effect 16.98 10.81 28 77772 3246 34875885
Urinary incontinence 16.93 10.81 85 77715 18789 34860342
Toxic epidermal necrolysis 16.88 10.81 14 77786 21632 34857499
Social avoidant behaviour 16.65 10.81 27 77773 3087 34876044
Depression suicidal 16.61 10.81 24 77776 2481 34876650
Action tremor 16.50 10.81 6 77794 59 34879072
Heat stroke 16.30 10.81 15 77785 950 34878181
Cerebral ventricle dilatation 16.29 10.81 15 77785 951 34878180
Sleep paralysis 16.19 10.81 8 77792 176 34878955
Diarrhoea neonatal 16.18 10.81 5 77795 28 34879103
Abdominal distension 16.16 10.81 71 77729 58421 34820710
Laboratory test abnormal 16.14 10.81 13 77787 20378 34858753
Fatigue 16.13 10.81 668 77132 369985 34509146
Floppy infant 16.08 10.81 7 77793 114 34879017
Blunted affect 16.04 10.81 10 77790 350 34878781
Nervousness 16.03 10.81 63 77737 12543 34866588
Skull fractured base 16.03 10.81 8 77792 180 34878951
Physical assault 15.94 10.81 16 77784 1129 34878002
Otospondylomegaepiphyseal dysplasia 15.91 10.81 7 77793 117 34879014
Tricuspid valve sclerosis 15.89 10.81 5 77795 30 34879101
Food craving 15.89 10.81 11 77789 461 34878670
COVID-19 pneumonia 15.86 10.81 9 77791 16958 34862173
Coagulation factor VII level decreased 15.86 10.81 7 77793 118 34879013
Spina bifida 15.82 10.81 10 77790 359 34878772
Gambling disorder 15.81 10.81 19 77781 1641 34877490
Newborn persistent pulmonary hypertension 15.75 10.81 7 77793 120 34879011
Derealisation 15.74 10.81 12 77788 585 34878546
Pseudohyponatraemia 15.74 10.81 6 77794 68 34879063
Drug reaction with eosinophilia and systemic symptoms 15.73 10.81 31 77769 32981 34846150
Cor pulmonale acute 15.72 10.81 9 77791 269 34878862
Crying 15.68 10.81 38 77762 5824 34873307
Drug hypersensitivity 15.63 10.81 259 77541 80270 34798861
Unemployment 15.61 10.81 5 77795 32 34879099
Micturition disorder 15.59 10.81 22 77778 2226 34876905
Selective mutism 15.51 10.81 6 77794 71 34879060
Cerebral microangiopathy 15.48 10.81 8 77792 194 34878937
Meningocele 15.36 10.81 5 77795 34 34879097
Respiratory arrest 15.34 10.81 111 77689 27932 34851199
Kleptomania 15.33 10.81 3 77797 0 34879131
Balance disorder 15.33 10.81 148 77652 40506 34838625
Congenital central nervous system anomaly 15.30 10.81 12 77788 610 34878521
Swelling 15.29 10.81 46 77754 42320 34836811
Obsessive-compulsive symptom 15.19 10.81 7 77793 131 34879000
Catecholamines urine increased 15.18 10.81 4 77796 11 34879120
Influenza 15.15 10.81 58 77742 49608 34829523
Delirium 15.07 10.81 157 77643 43834 34835297
Blood glucose increased 15.00 10.81 87 77713 66631 34812500
Hyponatraemic coma 14.99 10.81 5 77795 37 34879094
Lip pruritus 14.92 10.81 4 77796 12 34879119
Urinary straining 14.92 10.81 4 77796 12 34879119
Peritonitis 14.85 10.81 9 77791 16356 34862775
Obstructive airways disorder 14.80 10.81 8 77792 15486 34863645
Psychomotor retardation 14.78 10.81 28 77772 3622 34875509
Product dose omission issue 14.74 10.81 183 77617 119528 34759603
Distributive shock 14.73 10.81 16 77784 1238 34877893
Chest discomfort 14.58 10.81 67 77733 54463 34824668
Anticholinergic syndrome 14.58 10.81 16 77784 1253 34877878
Tachyphrenia 14.58 10.81 16 77784 1253 34877878
Peripheral swelling 14.57 10.81 105 77695 76436 34802695
Infantile vomiting 14.55 10.81 5 77795 41 34879090
Food interaction 14.54 10.81 14 77786 939 34878192
Onychomycosis 14.49 10.81 22 77778 2378 34876753
Ex-drug abuser 14.46 10.81 7 77793 147 34878984
Psychiatric symptom 14.28 10.81 27 77773 3486 34875645
Therapeutic response unexpected 14.27 10.81 51 77749 9706 34869425
Impulse-control disorder 14.25 10.81 16 77784 1285 34877846
Laryngomalacia 14.24 10.81 9 77791 323 34878808
Dyspnoea exertional 14.22 10.81 49 77751 43230 34835901
Blepharospasm 14.22 10.81 15 77785 1123 34878008
Deep vein thrombosis 14.19 10.81 86 77714 65162 34813969
Fungal infection 14.13 10.81 9 77791 15926 34863205
Dehydration 14.07 10.81 204 77596 129765 34749366
Dry mouth 14.05 10.81 115 77685 30050 34849081
Norepinephrine increased 14.04 10.81 4 77796 16 34879115
Antidepressant drug level above therapeutic 14.00 10.81 8 77792 238 34878893
Dizziness 13.96 10.81 607 77193 217914 34661217
Limited symptom panic attack 13.76 10.81 5 77795 49 34879082
Opisthotonus 13.68 10.81 10 77790 457 34878674
Rectal fissure 13.64 10.81 9 77791 348 34878783
Leukopenia 13.58 10.81 83 77717 62773 34816358
Congenital hydronephrosis 13.58 10.81 12 77788 721 34878410
Congenital skin dimples 13.57 10.81 7 77793 169 34878962
Dry skin 13.56 10.81 31 77769 31256 34847875
Withdrawal catatonia 13.55 10.81 6 77794 102 34879029
Diastolic hypotension 13.50 10.81 5 77795 52 34879079
Muscle necrosis 13.49 10.81 13 77787 873 34878258
Muscle tightness 13.43 10.81 32 77768 4852 34874279
Congestive cardiomyopathy 13.42 10.81 42 77758 7468 34871663
Affect lability 13.39 10.81 27 77773 3656 34875475
Sensory disturbance 13.38 10.81 37 77763 6140 34872991
Urine output decreased 13.34 10.81 3 77797 10046 34869085
Dysarthria 13.30 10.81 127 77673 34655 34844476
Blood urea increased 13.23 10.81 30 77770 30334 34848797
Rhinorrhoea 13.21 10.81 23 77777 25645 34853486
Cerebral disorder 13.16 10.81 22 77778 2579 34876552
Haematochezia 13.15 10.81 56 77744 46478 34832653
Pneumonia bacterial 13.10 10.81 5 77795 11867 34867264
Blood creatine phosphokinase increased 13.04 10.81 155 77645 44702 34834429
CADASIL 13.04 10.81 6 77794 112 34879019
Panic disorder 13.02 10.81 15 77785 1239 34877892
Ventricular septal defect 12.99 10.81 28 77772 3973 34875158
Urinary tract infection 12.97 10.81 122 77678 83959 34795172
Renal disorder 12.96 10.81 23 77777 25457 34853674
Skin exfoliation 12.87 10.81 26 77774 27406 34851725
Sexually inappropriate behaviour 12.86 10.81 10 77790 502 34878629
Anal stenosis 12.83 10.81 7 77793 190 34878941
Blood cholesterol increased 12.83 10.81 84 77716 20459 34858672
Gallbladder polyp 12.75 10.81 9 77791 389 34878742
Dissociative identity disorder 12.71 10.81 4 77796 24 34879107
Double inlet left ventricle 12.71 10.81 4 77796 24 34879107
Cerebrovascular accident 12.68 10.81 124 77676 84687 34794444
Insulin resistance 12.65 10.81 11 77789 647 34878484
Haemorrhage 12.64 10.81 65 77735 51305 34827826
Prescribed overdose 12.57 10.81 52 77748 10595 34868536
Onychophagia 12.57 10.81 5 77795 64 34879067
Full blood count decreased 12.57 10.81 13 77787 18075 34861056
Thrombotic microangiopathy 12.55 10.81 4 77796 10626 34868505
Heart rate increased 12.55 10.81 158 77642 46185 34832946
Accident at work 12.50 10.81 12 77788 802 34878329
Trismus 12.49 10.81 21 77779 2474 34876657
Hypersensitivity 12.47 10.81 82 77718 60953 34818178
Dysgraphia 12.46 10.81 20 77780 2267 34876864
Head discomfort 12.45 10.81 28 77772 4088 34875043
Inhibitory drug interaction 12.42 10.81 17 77783 1671 34877460
Convulsive threshold lowered 12.42 10.81 10 77790 528 34878603
Self esteem decreased 12.41 10.81 10 77790 529 34878602
Intentional product use issue 12.40 10.81 80 77720 59736 34819395
Small intestinal obstruction 12.37 10.81 9 77791 14857 34864274
Conjunctivitis viral 12.36 10.81 5 77795 67 34879064
Chills 12.32 10.81 118 77682 80925 34798206
Productive cough 12.29 10.81 43 77757 37770 34841361
Bezoar 12.28 10.81 14 77786 1143 34877988
Haemolytic anaemia 12.27 10.81 4 77796 10475 34868656
Vertebral foraminal stenosis 12.18 10.81 10 77790 543 34878588
Necrotising ulcerative gingivostomatitis 12.17 10.81 5 77795 70 34879061
Feeling drunk 12.14 10.81 18 77782 1905 34877226
Bladder cancer 12.12 10.81 11 77789 16267 34862864
Cogwheel rigidity 12.11 10.81 15 77785 1337 34877794
Attention deficit hyperactivity disorder 12.10 10.81 21 77779 2538 34876593
Substance abuse 12.09 10.81 41 77759 7600 34871531
Congenital ureterocele 12.05 10.81 3 77797 6 34879125
Magical thinking 12.05 10.81 3 77797 6 34879125
Candida infection 12.01 10.81 13 77787 17702 34861429
Anorgasmia 11.98 10.81 12 77788 845 34878286
Craniocerebral injury 11.95 10.81 24 77776 3239 34875892
Tongue pruritus 11.95 10.81 4 77796 30 34879101
Hallucination, tactile 11.93 10.81 8 77792 318 34878813
Pre-existing condition improved 11.90 10.81 21 77779 2571 34876560
Neutropenic sepsis 11.90 10.81 8 77792 13759 34865372
Cerebellar haematoma 11.88 10.81 7 77793 221 34878910
Pneumothorax 11.88 10.81 15 77785 19077 34860054
Ventricular arrhythmia 11.87 10.81 33 77767 5495 34873636
Hydrops foetalis 11.86 10.81 12 77788 855 34878276
Spasmodic dysphonia 11.82 10.81 7 77793 223 34878908
Tunnel vision 11.81 10.81 10 77790 567 34878564
Tinnitus 11.80 10.81 81 77719 20037 34859094
Genital hypoaesthesia 11.79 10.81 7 77793 224 34878907
Magnetic resonance imaging spinal abnormal 11.78 10.81 6 77794 141 34878990
Acute myeloid leukaemia 11.74 10.81 14 77786 18256 34860875
Basal cell carcinoma 11.66 10.81 16 77784 19642 34859489
Depressive symptom 11.66 10.81 22 77778 2837 34876294
Dysphemia 11.64 10.81 16 77784 1579 34877552
Tryptase increased 11.63 10.81 7 77793 230 34878901
Gonadotrophin deficiency 11.62 10.81 4 77796 33 34879098
Nonspecific reaction 11.60 10.81 15 77785 1396 34877735
Flashback 11.59 10.81 6 77794 146 34878985
Bundle branch block 11.55 10.81 12 77788 882 34878249
Alcohol poisoning 11.50 10.81 25 77775 3568 34875563
Blood lactate dehydrogenase increased 11.47 10.81 21 77779 22969 34856162
Hypotonia 11.44 10.81 41 77759 7812 34871319
Hypocalcaemia 11.41 10.81 23 77777 24266 34854865
Anhedonia 11.39 10.81 40 77760 7545 34871586
Antipsychotic drug level increased 11.36 10.81 26 77774 3839 34875292
Squamous cell carcinoma of skin 11.33 10.81 5 77795 10876 34868255
Univentricular heart 11.31 10.81 4 77796 36 34879095
Blood potassium increased 11.30 10.81 12 77788 16483 34862648
Repetitive speech 11.29 10.81 5 77795 85 34879046
Vascular malformation 11.29 10.81 5 77795 85 34879046
Haemoptysis 11.25 10.81 40 77760 34966 34844165
Implant site infection 11.25 10.81 13 77787 1077 34878054
Neonatal hypotension 11.23 10.81 6 77794 156 34878975
Hypersomnia 11.21 10.81 56 77744 12351 34866780
Pancreatic carcinoma 11.15 10.81 3 77797 8898 34870233
Delayed fontanelle closure 11.12 10.81 4 77796 38 34879093
Spondylolisthesis 11.08 10.81 11 77789 766 34878365
Generalised oedema 11.01 10.81 7 77793 12401 34866730
Right ventricular failure 10.93 10.81 3 77797 8781 34870350
Bite 10.93 10.81 5 77795 92 34879039
Oromandibular dystonia 10.91 10.81 9 77791 492 34878639
Back pain 10.91 10.81 198 77602 121591 34757540
Immune reconstitution inflammatory syndrome 10.88 10.81 3 77797 8756 34870375
Flight of ideas 10.88 10.81 8 77792 369 34878762

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2120.54 9.94 2960 214358 242807 79284263
Serotonin syndrome 1673.16 9.94 1205 216113 43822 79483248
Intentional overdose 1415.04 9.94 1590 215728 104370 79422700
Toxicity to various agents 1292.04 9.94 3253 214065 418287 79108783
Suicide attempt 1192.59 9.94 1294 216024 81638 79445432
Suicidal ideation 1065.99 9.94 1173 216145 75167 79451903
Overdose 954.80 9.94 1761 215557 182445 79344625
Drug withdrawal syndrome 927.47 9.94 764 216554 33954 79493116
Poisoning deliberate 622.69 9.94 470 216848 18358 79508712
Coma 576.88 9.94 1006 216312 99643 79427427
Intentional self-injury 564.84 9.94 561 216757 31858 79495212
Withdrawal syndrome 551.82 9.94 509 216809 26345 79500725
Drug abuse 547.83 9.94 1304 216014 161387 79365683
Sopor 495.06 9.94 527 216791 32483 79494587
Drug interaction 485.72 9.94 2327 214991 412856 79114214
Agitation 405.64 9.94 862 216456 98853 79428217
Mydriasis 373.34 9.94 340 216978 17303 79509767
Hyperhidrosis 369.56 9.94 1077 216241 150415 79376655
Somnolence 351.34 9.94 1435 215883 237546 79289524
Depression 347.03 9.94 1337 215981 215453 79311617
Electrocardiogram QT prolonged 338.71 9.94 756 216562 89630 79437440
Tremor 337.07 9.94 1125 216193 168958 79358112
Anxiety 335.56 9.94 1454 215864 247058 79280012
Synovitis 310.62 9.94 27 217291 150707 79376363
Febrile neutropenia 273.64 9.94 144 217174 230855 79296215
Seizure 252.55 9.94 1102 216216 187732 79339338
Depressed mood 248.74 9.94 462 216856 48018 79479052
Akathisia 239.36 9.94 234 217084 13025 79514045
Hand deformity 233.43 9.94 12 217306 103907 79423163
Nightmare 225.77 9.94 314 217004 25547 79501523
Pneumonia 224.79 9.94 981 216337 659265 78867805
Disturbance in attention 220.31 9.94 451 216867 50350 79476720
Joint swelling 219.02 9.94 279 217039 288367 79238703
Irritability 205.96 9.94 388 216930 40756 79486314
Pericarditis 196.05 9.94 26 217292 104210 79422860
Crying 194.04 9.94 275 217043 22768 79504302
Mania 187.46 9.94 240 217078 18020 79509050
Systemic lupus erythematosus 184.08 9.94 51 217267 121098 79405972
Infusion related reaction 183.64 9.94 214 217104 230023 79297047
Sepsis 180.00 9.94 285 217033 269143 79257927
Pyrexia 179.28 9.94 1100 216218 677609 78849461
Anaemia 172.91 9.94 627 216691 444388 79082682
Infection 172.79 9.94 244 217074 241468 79285602
Restlessness 170.87 9.94 386 216932 46106 79480964
Rash 168.97 9.94 907 216411 577451 78949619
Duodenal ulcer perforation 165.22 9.94 3 217315 66208 79460862
Glossodynia 163.68 9.94 40 217278 103297 79423773
Contraindicated product administered 163.06 9.94 115 217203 157423 79369647
Generalised tonic-clonic seizure 161.86 9.94 365 216953 43545 79483525
Feeling abnormal 157.26 9.94 852 216466 158347 79368723
Poisoning 157.02 9.94 262 217056 25010 79502060
Helicobacter infection 153.59 9.94 9 217309 69695 79457375
Drug dependence 151.51 9.94 340 216978 40429 79486641
Panic attack 150.38 9.94 251 217067 23965 79503105
Arthropathy 149.58 9.94 157 217161 176954 79350116
Anger 149.23 9.94 208 217110 16954 79510116
Rheumatoid factor positive 148.14 9.94 3 217315 59836 79467234
Neutropenia 146.61 9.94 357 216961 287353 79239717
Tachycardia 144.79 9.94 904 216414 176864 79350206
Altered state of consciousness 139.48 9.94 344 216974 43478 79483592
Off label use 138.91 9.94 1695 215623 905520 78621550
Cardio-respiratory arrest 138.69 9.94 625 216693 107885 79419185
Psychomotor hyperactivity 135.88 9.94 197 217121 16652 79510418
Hyperreflexia 134.85 9.94 139 217179 8246 79518824
Alopecia 133.51 9.94 268 217050 231087 79295983
Disease progression 131.83 9.94 186 217132 184176 79342894
Platelet count decreased 131.78 9.94 204 217114 194460 79332610
Intentional product misuse 130.63 9.94 560 216758 94605 79432465
Swelling 130.29 9.94 245 217073 216466 79310604
Stomatitis 128.58 9.94 126 217192 146631 79380439
Sedation 128.35 9.94 371 216947 51524 79475546
Stress cardiomyopathy 126.18 9.94 154 217164 11012 79516058
Insomnia 125.64 9.94 1117 216201 244053 79283017
Major depression 125.20 9.94 138 217180 8842 79518228
Muscle rigidity 124.69 9.94 207 217111 19675 79507395
Myoclonus 121.60 9.94 247 217071 27413 79499657
Extrapyramidal disorder 121.19 9.94 220 217098 22459 79504611
Cardiac arrest 119.46 9.94 841 216477 171255 79355815
Respiratory arrest 118.61 9.94 386 216932 57164 79469906
Homicide 115.60 9.94 59 217259 1127 79525943
Gestational diabetes 115.34 9.94 112 217206 6181 79520889
Wound 114.79 9.94 89 217229 116090 79410980
Aggression 109.75 9.94 347 216971 50611 79476459
Bipolar disorder 108.43 9.94 119 217199 7588 79519482
Malignant neoplasm progression 107.73 9.94 127 217191 135863 79391207
Hypersensitivity 106.04 9.94 363 216955 261876 79265194
Electrocardiogram QRS complex prolonged 105.91 9.94 139 217179 10694 79516376
Delusion 105.19 9.94 195 217123 20228 79506842
Drug hypersensitivity 104.63 9.94 1260 216058 297656 79229414
Cataplexy 104.43 9.94 51 217267 883 79526187
C-reactive protein abnormal 104.30 9.94 7 217311 48360 79478710
Mood swings 103.88 9.94 191 217127 19689 79507381
Confusional state 102.97 9.94 1321 215997 316676 79210394
Renal impairment 102.39 9.94 170 217148 157613 79369457
Rheumatoid arthritis 101.24 9.94 265 217053 208205 79318865
Antidepressant drug level above therapeutic 100.65 9.94 45 217273 631 79526439
Product substitution issue 98.86 9.94 189 217129 20067 79507003
Hallucination, auditory 98.44 9.94 191 217127 20502 79506568
Thrombocytopenia 96.86 9.94 383 216935 264876 79262194
Galactorrhoea 96.82 9.94 80 217238 3566 79523504
Muscle injury 96.54 9.94 10 217308 48551 79478519
Disorientation 96.04 9.94 382 216936 62394 79464676
Arthralgia 95.54 9.94 1047 216271 570756 78956314
Therapeutic product effect decreased 95.20 9.94 189 217129 163674 79363396
Restless legs syndrome 95.03 9.94 185 217133 19907 79507163
Folliculitis 94.69 9.94 18 217300 55362 79471708
Neuroleptic malignant syndrome 93.76 9.94 222 217096 27337 79499733
Tearfulness 93.24 9.94 98 217220 5947 79521123
Treatment failure 92.86 9.94 204 217114 170282 79356788
Hallucination, visual 92.83 9.94 246 217072 32483 79494587
Tardive dyskinesia 91.73 9.94 128 217190 10443 79516627
Sinus tachycardia 91.40 9.94 264 217054 36644 79490426
Blister 91.01 9.94 115 217203 119361 79407709
Peripheral swelling 89.97 9.94 403 216915 269214 79257856
Impaired healing 88.05 9.94 66 217252 87589 79439481
Loss of consciousness 86.92 9.94 767 216551 167176 79359894
Pancytopenia 86.47 9.94 203 217115 165542 79361528
Haemoglobin decreased 86.07 9.94 313 217005 221806 79305264
Dyskinesia 85.76 9.94 293 217025 44480 79482590
Apathy 83.92 9.94 137 217181 12840 79514230
Diarrhoea 83.75 9.94 1797 215521 878692 78648378
Foetal death 82.99 9.94 106 217212 7938 79519132
Nervousness 82.73 9.94 239 217079 33176 79493894
Lung diffusion test abnormal 81.44 9.94 33 217285 357 79526713
Dyspnoea 81.24 9.94 1750 215568 855275 78671795
Acute kidney injury 80.87 9.94 966 216352 518438 79008632
Parkinsonism 78.80 9.94 153 217165 16431 79510639
Thinking abnormal 78.51 9.94 134 217184 13027 79514043
Somnambulism 78.18 9.94 87 217231 5634 79521436
Septic shock 78.10 9.94 134 217184 122667 79404403
Sleep disorder due to general medical condition, insomnia type 76.97 9.94 13 217305 43543 79483527
Sleep-related eating disorder 76.88 9.94 38 217280 676 79526394
Mental disorder 75.68 9.94 222 217096 31080 79495990
Abnormal behaviour 75.68 9.94 245 217073 36176 79490894
Decorticate posture 75.08 9.94 30 217288 312 79526758
Myocardial depression 74.90 9.94 34 217284 495 79526575
Myelosuppression 73.53 9.94 11 217307 40285 79486785
Psychotic disorder 72.45 9.94 263 217055 41139 79485931
Postmortem blood drug level increased 72.39 9.94 38 217280 771 79526299
Discomfort 72.00 9.94 146 217172 125471 79401599
Clonus 71.94 9.94 91 217227 6749 79520321
Bone marrow failure 71.37 9.94 25 217293 51082 79475988
Pleural effusion 71.00 9.94 184 217134 145078 79381992
Mental impairment 70.99 9.94 159 217159 18877 79508193
Antidepressant drug level increased 70.23 9.94 31 217287 421 79526649
Mobility decreased 69.18 9.94 143 217175 122032 79405038
Self-injurious ideation 69.04 9.94 66 217252 3572 79523498
Lymphocytic oesophagitis 68.95 9.94 17 217301 23 79527047
Blood creatinine increased 68.67 9.94 206 217112 154851 79372219
C-reactive protein increased 68.12 9.94 157 217161 128870 79398200
Homicidal ideation 68.05 9.94 64 217254 3393 79523677
Psychotic symptom 67.11 9.94 57 217261 2640 79524430
Urinary incontinence 66.69 9.94 254 217064 40655 79486415
Migraine 65.67 9.94 436 216882 87057 79440013
Gastrointestinal haemorrhage 64.87 9.94 197 217121 147522 79379548
Camptocormia 64.82 9.94 30 217288 458 79526612
Cytomegalovirus infection 64.66 9.94 18 217300 42626 79484444
Psychomotor retardation 64.60 9.94 82 217236 6102 79520968
Malignant mediastinal neoplasm 64.56 9.94 43 217275 1372 79525698
Neuropathy peripheral 64.55 9.94 185 217133 141120 79385950
Nasopharyngitis 64.42 9.94 416 216902 253465 79273605
Libido decreased 64.41 9.94 76 217242 5245 79521825
Physical assault 64.12 9.94 45 217273 1566 79525504
Abnormal dreams 63.91 9.94 113 217205 11299 79515771
Coma scale abnormal 63.57 9.94 97 217221 8581 79518489
Hepatic enzyme increased 63.28 9.94 269 217049 182341 79344729
Oedema 62.73 9.94 146 217172 119434 79407636
Hypomania 61.99 9.94 89 217229 7455 79519615
Hypertonia 61.90 9.94 87 217231 7145 79519925
Suicidal behaviour 61.79 9.94 59 217259 3188 79523882
Atrial fibrillation 61.73 9.94 303 217015 197583 79329487
Feelings of worthlessness 61.29 9.94 30 217288 522 79526548
Dissociation 59.91 9.94 64 217254 3957 79523113
Abdominal discomfort 59.05 9.94 420 216898 250307 79276763
Pneumocystis jirovecii pneumonia 59.02 9.94 9 217309 32499 79494571
Sinusitis 58.89 9.94 303 217015 195198 79331872
Erectile dysfunction 58.67 9.94 126 217192 14538 79512532
Memory impairment 58.15 9.94 511 216807 111223 79415847
Mood altered 57.74 9.94 141 217177 17706 79509364
Impulsive behaviour 57.68 9.94 54 217264 2846 79524224
Respiratory failure 57.59 9.94 275 217043 180636 79346434
Maternal exposure during pregnancy 57.20 9.94 186 217132 136352 79390718
Cytokine release syndrome 56.86 9.94 14 217304 35984 79491086
Psoriatic arthropathy 56.41 9.94 78 217240 77921 79449149
Logorrhoea 55.60 9.94 64 217254 4301 79522769
Inappropriate antidiuretic hormone secretion 55.57 9.94 178 217140 26135 79500935
Paraesthesia 55.10 9.94 728 216590 175595 79351475
Euphoric mood 54.68 9.94 85 217233 7641 79519429
Paranoia 54.03 9.94 145 217173 19287 79507783
Abulia 53.92 9.94 34 217284 986 79526084
Somatic symptom disorder 53.88 9.94 49 217269 2488 79524582
Oedema peripheral 53.55 9.94 435 216883 251853 79275217
Meconium in amniotic fluid 53.47 9.94 18 217300 109 79526961
Hallucination 53.14 9.94 408 216910 85337 79441733
Vertigo 52.90 9.94 346 216972 68736 79458334
Neovascularisation 52.42 9.94 36 217282 1209 79525861
Bezoar 51.45 9.94 49 217269 2639 79524431
Ascites 51.27 9.94 79 217239 75483 79451587
Emotional disorder 51.24 9.94 118 217200 14269 79512801
Bruxism 51.23 9.94 59 217259 3967 79523103
Hepatic function abnormal 50.99 9.94 75 217243 73032 79454038
Toxic epidermal necrolysis 50.97 9.94 29 217289 44552 79482518
Persecutory delusion 49.56 9.94 64 217254 4845 79522225
Benzodiazepine drug level increased 49.39 9.94 20 217298 216 79526854
Full blood count abnormal 49.36 9.94 230 217088 40244 79486826
Dizziness 48.24 9.94 1821 215497 524620 79002450
Dysphoria 48.24 9.94 62 217256 4672 79522398
Red blood cell sedimentation rate increased 48.22 9.94 33 217285 45909 79481161
Gastrointestinal disorder 48.11 9.94 171 217147 122034 79405036
Hip arthroplasty 47.39 9.94 19 217299 35737 79491333
Irritable bowel syndrome 47.29 9.94 60 217258 62181 79464889
Panic disorder 47.03 9.94 49 217269 2943 79524127
Ill-defined disorder 46.52 9.94 67 217251 65808 79461262
Muscle twitching 46.49 9.94 161 217157 24603 79502467
Lower respiratory tract infection 46.22 9.94 188 217130 129032 79398038
Persistent genital arousal disorder 46.02 9.94 20 217298 261 79526809
Amnesia 45.97 9.94 312 217006 62745 79464325
Cardiogenic shock 45.94 9.94 231 217087 41683 79485387
Pruritus 45.77 9.94 778 216540 393870 79133200
Inappropriate affect 45.65 9.94 36 217282 1500 79525570
Pain 45.09 9.94 1519 215799 702283 78824787
Pyramidal tract syndrome 44.93 9.94 25 217293 572 79526498
Accommodation disorder 44.89 9.94 25 217293 573 79526497
Epilepsy 44.65 9.94 225 217093 40635 79486435
Loss of libido 44.06 9.94 45 217273 2640 79524430
Interstitial lung disease 44.03 9.94 158 217160 112442 79414628
White blood cell count decreased 43.54 9.94 317 217001 187971 79339099
Social anxiety disorder 43.22 9.94 24 217294 547 79526523
Hyperkalaemia 43.11 9.94 163 217155 114235 79412835
Anorgasmia 43.00 9.94 32 217286 1222 79525848
Opsoclonus myoclonus 42.91 9.94 18 217300 214 79526856
Antidepressant discontinuation syndrome 42.86 9.94 12 217306 34 79527036
Hyponatraemia 42.85 9.94 702 216616 177146 79349924
Anticholinergic syndrome 42.76 9.94 51 217267 3560 79523510
Personality disorder 42.64 9.94 67 217251 6079 79520991
Hostility 42.12 9.94 41 217277 2269 79524801
Erythema 42.06 9.94 397 216921 222893 79304177
Drug screen positive 41.93 9.94 66 217252 5997 79521073
Blood bilirubin increased 41.44 9.94 73 217245 66159 79460911
Intentional product use issue 41.28 9.94 244 217074 151868 79375202
Libido increased 41.23 9.94 38 217280 1963 79525107
Pleurothotonus 40.98 9.94 42 217276 2474 79524596
General physical health deterioration 40.81 9.94 517 216801 274721 79252349
Depressive symptom 40.44 9.94 67 217251 6356 79520714
Delirium 40.44 9.94 380 216938 84247 79442823
Accidental death 40.31 9.94 54 217264 4237 79522833
Obsessive-compulsive disorder 40.28 9.94 64 217254 5863 79521207
Cerebral infarction 40.23 9.94 39 217279 45637 79481433
Weight increased 40.20 9.94 1015 216303 276371 79250699
Anaphylactic reaction 40.20 9.94 107 217211 83636 79443434
Antipsychotic drug level above therapeutic 39.97 9.94 38 217280 2042 79525028
Alcoholism 39.90 9.94 50 217268 3673 79523397
Dysarthria 39.82 9.94 318 217000 67304 79459766
Respiratory depression 39.76 9.94 165 217153 27465 79499605
Hyperprolactinaemia 39.65 9.94 56 217262 4620 79522450
Product use issue 39.54 9.94 373 216945 209449 79317621
Nystagmus 39.51 9.94 85 217233 9819 79517251
Enuresis 39.50 9.94 46 217272 3130 79523940
Hereditary non-polyposis colorectal cancer syndrome 39.26 9.94 8 217310 0 79527070
Feeling jittery 38.96 9.94 99 217219 12742 79514328
Prostate cancer 38.96 9.94 21 217297 33247 79493823
Electric shock sensation 38.94 9.94 26 217292 833 79526237
Endometriosis 38.89 9.94 49 217269 3619 79523451
Social avoidant behaviour 38.40 9.94 56 217262 4758 79522312
Panic reaction 38.28 9.94 55 217263 4610 79522460
Mucosal inflammation 38.26 9.94 94 217224 75486 79451584
Drug ineffective for unapproved indication 38.24 9.94 255 217063 50983 79476087
Urinary retention 38.23 9.94 275 217043 56355 79470715
Tubulointerstitial nephritis 38.12 9.94 29 217289 38206 79488864
Colitis microscopic 38.00 9.94 88 217230 10680 79516390
Skin candida 37.98 9.94 37 217281 2050 79525020
Death 37.83 9.94 1216 216102 565298 78961772
Hypothermia 37.71 9.94 142 217176 22604 79504466
Dissociative disorder 37.58 9.94 25 217293 796 79526274
Fall 37.56 9.94 1656 215662 485973 79041097
Reversible cerebral vasoconstriction syndrome 37.56 9.94 44 217274 3013 79524057
Sexual dysfunction 37.34 9.94 72 217246 7691 79519379
Amniorrhexis 37.20 9.94 10 217308 23 79527047
COVID-19 37.16 9.94 264 217054 157410 79369660
Pulmonary pain 37.09 9.94 53 217265 4420 79522650
Feeling of despair 37.01 9.94 42 217276 2779 79524291
Drug eruption 37 9.94 39 217279 43896 79483174
Rhabdomyolysis 37.00 9.94 437 216881 102694 79424376
Hot flush 36.76 9.94 266 217052 54611 79472459
Bronchopulmonary aspergillosis 36.54 9.94 8 217310 22286 79504784
Nephropathy toxic 36.29 9.94 6 217312 20413 79506657
Miosis 36.29 9.94 110 217208 15679 79511391
Rheumatoid nodule 36.24 9.94 3 217315 17435 79509635
Plasma cell myeloma 35.83 9.94 56 217262 53203 79473867
Cardiotoxicity 35.73 9.94 93 217225 12146 79514924
Bradyphrenia 35.42 9.94 85 217233 10555 79516515
Self esteem decreased 35.33 9.94 26 217292 976 79526094
Derealisation 35.31 9.94 32 217286 1617 79525453
Persistent depressive disorder 35.30 9.94 28 217290 1177 79525893
Cardiac failure congestive 35.25 9.94 235 217083 142167 79384903
Cardiac failure 35.16 9.94 262 217056 154580 79372490
Colitis 34.93 9.94 94 217224 73213 79453857
Congestive cardiomyopathy 34.89 9.94 90 217228 11690 79515380
Suspected suicide 34.68 9.94 84 217234 10492 79516578
Tumour lysis syndrome 34.66 9.94 11 217307 23928 79503142
Metabolic syndrome 34.61 9.94 40 217278 2700 79524370
Haematuria 34.54 9.94 86 217232 68750 79458320
Iodine allergy 34.54 9.94 21 217297 570 79526500
Toxicologic test abnormal 34.37 9.94 29 217289 1331 79525739
Hypersomnia 34.11 9.94 139 217179 22947 79504123
International normalised ratio increased 33.71 9.94 118 217200 84603 79442467
Negative thoughts 33.66 9.94 29 217289 1370 79525700
Joint range of motion decreased 33.49 9.94 25 217293 33257 79493813
Leukopenia 33.17 9.94 184 217134 116329 79410741
Pain in extremity 33.03 9.94 749 216569 363789 79163281
Drug screen false positive 32.98 9.94 26 217292 1083 79525987
Electrocardiogram QRS complex shortened 32.86 9.94 22 217296 708 79526362
Reduced facial expression 32.65 9.94 39 217279 2726 79524344
Tachyphrenia 32.58 9.94 34 217284 2046 79525024
Neutrophil count decreased 32.17 9.94 139 217179 93820 79433250
Pneumonitis 32.15 9.94 74 217244 60786 79466284
Cytopenia 32.05 9.94 8 217310 20375 79506695
Transplant rejection 31.81 9.94 7 217311 19430 79507640
Liver disorder 31.48 9.94 97 217221 72320 79454750
Tenosynovitis 31.45 9.94 3 217315 15551 79511519
Haematotoxicity 31.36 9.94 3 217315 15516 79511554
Victim of sexual abuse 31.34 9.94 19 217299 513 79526557
Bacteraemia 31.34 9.94 26 217292 32798 79494272
Musculoskeletal stiffness 31.33 9.94 315 217003 174693 79352377
Cough 31.18 9.94 761 216557 366028 79161042
Phagophobia 30.98 9.94 10 217308 52 79527018
Tinnitus 30.92 9.94 217 217101 44116 79482954
Adjustment disorder with mixed anxiety and depressed mood 30.72 9.94 12 217306 117 79526953
Palmar-plantar erythrodysaesthesia syndrome 30.71 9.94 27 217291 33107 79493963
Skin necrosis 30.66 9.94 6 217312 18081 79508989
Hepatocellular injury 30.34 9.94 228 217090 47365 79479705
Postmortem blood drug level abnormal 30.14 9.94 20 217298 634 79526436
Nervous system disorder 30.13 9.94 149 217169 26707 79500363
Psychiatric symptom 29.95 9.94 62 217256 6973 79520097
Substance abuse 29.72 9.94 79 217239 10447 79516623
Product tampering 29.72 9.94 17 217301 411 79526659
Headache 29.66 9.94 2115 215203 651657 78875413
Head discomfort 29.62 9.94 97 217221 14405 79512665
Lung disorder 29.56 9.94 116 217202 80441 79446629
Decreased interest 29.48 9.94 43 217275 3654 79523416
Product residue present 29.47 9.94 42 217276 3494 79523576
Endolymphatic hydrops 29.45 9.94 6 217312 0 79527070
Feeling drunk 29.41 9.94 49 217269 4670 79522400
Tension 29.16 9.94 47 217271 4357 79522713
Parkinsonism hyperpyrexia syndrome 29.11 9.94 14 217304 234 79526836
Kleptomania 29.02 9.94 8 217310 21 79527049
Myelodysplastic syndrome 28.93 9.94 24 217294 30277 79496793
Vision blurred 28.92 9.94 427 216891 105471 79421599
Middle insomnia 28.90 9.94 103 217215 15966 79511104
Slow response to stimuli 28.89 9.94 30 217288 1795 79525275
Speech disorder 28.83 9.94 250 217068 54195 79472875
Acute myeloid leukaemia 28.83 9.94 25 217293 30860 79496210
HELLP syndrome 28.61 9.94 21 217297 785 79526285
Ejaculation disorder 28.58 9.94 18 217300 521 79526549
Epstein-Barr virus infection 28.57 9.94 3 217315 14413 79512657
Concussion 28.55 9.94 73 217245 9430 79517640
Tongue biting 28.54 9.94 32 217286 2089 79524981
Unemployment 28.50 9.94 9 217309 43 79527027
Renal failure 28.48 9.94 381 216937 200587 79326483
Thrombosis 28.43 9.94 125 217193 83975 79443095
Rapid eye movement sleep behaviour disorder 28.37 9.94 17 217301 449 79526621
Antipsychotic drug level increased 28.35 9.94 55 217263 5902 79521168
Dependence 28.34 9.94 34 217284 2388 79524682
Acute myocardial infarction 28.22 9.94 111 217207 76925 79450145
Cogwheel rigidity 27.70 9.94 38 217280 3050 79524020
Right ventricular failure 27.27 9.94 15 217303 23482 79503588
Vasoplegia syndrome 27.19 9.94 41 217277 3589 79523481
Therapeutic response unexpected 27.06 9.94 117 217201 19829 79507241
Alcohol interaction 26.95 9.94 48 217270 4826 79522244
Depressed level of consciousness 26.90 9.94 391 216927 96261 79430809
Adulterated product 26.85 9.94 14 217304 280 79526790
Osteonecrosis of jaw 26.72 9.94 48 217270 43178 79483892
Bradypnoea 26.54 9.94 54 217264 5998 79521072
Yawning 26.34 9.94 25 217293 1341 79525729
Drug intolerance 26.13 9.94 535 216783 263584 79263486
Thermophobia 26.13 9.94 9 217309 59 79527011
Multiple organ dysfunction syndrome 26.10 9.94 206 217112 120040 79407030
Sleep disorder 26.02 9.94 352 216966 85325 79441745
Balance disorder 25.98 9.94 396 216922 98461 79428609
Pathogen resistance 25.97 9.94 4 217314 14338 79512732
Tonic convulsion 25.70 9.94 31 217287 2189 79524881
Transfusion 25.66 9.94 13 217305 21317 79505753
Neoplasm progression 25.59 9.94 65 217253 51617 79475453
Product used for unknown indication 25.56 9.94 26 217292 1518 79525552
Drug use disorder 25.52 9.94 66 217252 8585 79518485
Blood creatine phosphokinase increased 25.47 9.94 284 217034 65806 79461264
Affect lability 25.46 9.94 78 217240 11181 79515889
Herpes zoster 25.41 9.94 149 217169 92934 79434136
Substance abuser 25.28 9.94 11 217307 144 79526926
Heart rate increased 25.27 9.94 466 216852 120258 79406812
Respiratory tract inflammation 25.06 9.94 20 217298 848 79526222
Haemoptysis 25.06 9.94 74 217244 55925 79471145
COVID-19 pneumonia 24.98 9.94 25 217293 28824 79498246
Dropped head syndrome 24.87 9.94 14 217304 328 79526742
Urticaria 24.85 9.94 355 216963 184846 79342224
Poor quality sleep 24.74 9.94 125 217193 22597 79504473
Pressure of speech 24.68 9.94 23 217295 1205 79525865
Hospitalisation 24.60 9.94 153 217165 94083 79432987
Aplastic anaemia 24.59 9.94 9 217309 17896 79509174
Macrophages increased 24.58 9.94 13 217305 268 79526802
Schizophreniform disorder 24.56 9.94 11 217307 155 79526915
ECG P wave inverted 24.54 9.94 5 217313 0 79527070
Cognitive disorder 24.50 9.94 295 217023 69631 79457439
Renal papillary necrosis 24.42 9.94 15 217303 415 79526655
Brain death 24.13 9.94 50 217268 5627 79521443
Depression suicidal 24.09 9.94 40 217278 3802 79523268
Blood immunoglobulin E increased 24.06 9.94 51 217267 5831 79521239
Distributive shock 24.01 9.94 33 217285 2654 79524416
Frustration tolerance decreased 23.98 9.94 59 217259 7443 79519627
Hyperthermia 23.86 9.94 105 217213 17932 79509138
Hypocalcaemia 23.80 9.94 64 217254 49860 79477210
Narcolepsy 23.78 9.94 23 217295 1263 79525807
Blood urea increased 23.67 9.94 62 217256 48728 79478342
Peritonitis 23.48 9.94 25 217293 28011 79499059
Hypercalcaemia 23.46 9.94 43 217275 38387 79488683
Coma acidotic 23.39 9.94 10 217308 125 79526945
Drug abuser 23.29 9.94 51 217267 5962 79521108
Kidney duplex 23.23 9.94 6 217312 11 79527059
Spontaneous ejaculation 23.23 9.94 6 217312 11 79527059
Thrombotic microangiopathy 23.23 9.94 13 217305 20156 79506914
Multiple sclerosis 23.16 9.94 121 217197 22161 79504909
Amenorrhoea 23.02 9.94 59 217259 7633 79519437
Splenomegaly 23.02 9.94 14 217304 20740 79506330
Pulmonary fibrosis 23.01 9.94 54 217264 44058 79483012
Abnormal weight gain 22.92 9.94 32 217286 2612 79524458
Haemolytic anaemia 22.76 9.94 10 217308 17810 79509260
Loose associations 22.66 9.94 8 217310 57 79527013
Basal cell carcinoma 22.66 9.94 42 217276 37333 79489737
Amyloid arthropathy 22.62 9.94 16 217302 564 79526506
Arthritis 22.59 9.94 202 217116 114678 79412392
External auditory canal atresia 22.57 9.94 6 217312 13 79527057
Haemophagocytic lymphohistiocytosis 22.50 9.94 16 217302 21821 79505249
Eye movement disorder 22.49 9.94 60 217258 7951 79519119
Merycism 22.49 9.94 12 217306 252 79526818
Osteoporosis 22.45 9.94 74 217244 54038 79473032
Paradoxical drug reaction 22.43 9.94 56 217262 7129 79519941
Neurodegenerative disorder 22.43 9.94 15 217303 482 79526588
Male orgasmic disorder 22.42 9.94 8 217310 59 79527011
Cytomegalovirus viraemia 22.27 9.94 4 217314 12817 79514253
Iris coloboma 22.26 9.94 6 217312 14 79527056
Retinal coloboma 22.26 9.94 6 217312 14 79527056
Radiation inflammation 22.26 9.94 19 217299 886 79526184
Erythema dyschromicum perstans 22.19 9.94 8 217310 61 79527009
Liver function test increased 22.13 9.94 47 217271 39726 79487344
Affective disorder 22.05 9.94 61 217257 8258 79518812
Blood lactate dehydrogenase increased 22.03 9.94 46 217272 39124 79487946
Drug level increased 22.01 9.94 184 217134 39467 79487603
Cardiomyopathy 21.95 9.94 144 217174 28630 79498440
Second primary malignancy 21.86 9.94 6 217312 14344 79512726
Cataract 21.82 9.94 91 217227 62029 79465041
Fluid retention 21.68 9.94 107 217211 69702 79457368
Food aversion 21.54 9.94 20 217298 1043 79526027
Gambling disorder 21.38 9.94 27 217291 1999 79525071
Respiratory tract infection 21.31 9.94 65 217253 48624 79478446
Device related infection 21.27 9.94 38 217280 34256 79492814
Sleep paralysis 21.25 9.94 16 217302 622 79526448
Testicular atrophy 21.21 9.94 13 217305 358 79526712
Helplessness 21.18 9.94 13 217305 359 79526711
Acquired amegakaryocytic thrombocytopenia 21.18 9.94 6 217312 18 79527052
Cold sweat 21.16 9.94 104 217214 18595 79508475
Skin ulcer 21.15 9.94 76 217242 54074 79472996
Allergy to venom 21.09 9.94 5 217313 5 79527065
Adrenal insufficiency 21.08 9.94 28 217290 28459 79498611
Catatonia 21.07 9.94 62 217256 8694 79518376
Phaeochromocytoma malignant 21.04 9.94 8 217310 72 79526998
Therapy non-responder 21.04 9.94 156 217162 92149 79434921
Incoherent 20.98 9.94 57 217261 7635 79519435
Muscle mass 20.93 9.94 14 217304 450 79526620
Pulse abnormal 20.91 9.94 35 217283 3349 79523721
Hypokinesia 20.85 9.94 105 217213 18955 79508115
Otospondylomegaepiphyseal dysplasia 20.85 9.94 7 217311 42 79527028
Soft tissue injury 20.83 9.94 25 217293 1756 79525314
Creatinine renal clearance decreased 20.82 9.94 13 217305 18989 79508081
Diffuse large B-cell lymphoma 20.66 9.94 4 217314 12145 79514925
Palpitations 20.65 9.94 471 216847 126139 79400931
Emotional poverty 20.56 9.94 18 217300 869 79526201
Obsessive thoughts 20.47 9.94 20 217298 1112 79525958
Bradykinesia 20.36 9.94 58 217260 7985 79519085
Melaena 20.28 9.94 91 217227 60799 79466271
Oesophageal carcinoma 20.28 9.94 3 217315 11081 79515989
Pre-existing condition improved 20.22 9.94 46 217272 5517 79521553
Neurotoxicity 20.20 9.94 36 217282 32482 79494588
Proteinuria 20.17 9.94 36 217282 32466 79494604
Cellulitis 20.05 9.94 195 217123 108865 79418205
Hypervigilance 20.00 9.94 14 217304 485 79526585
Depersonalisation/derealisation disorder 19.94 9.94 25 217293 1837 79525233
Anhedonia 19.91 9.94 87 217231 14811 79512259
Fear 19.90 9.94 115 217203 21871 79505199
Graft versus host disease 19.89 9.94 8 217310 15018 79512052
External ear disorder 19.87 9.94 8 217310 85 79526985
Trunk injury 19.86 9.94 6 217312 24 79527046
Nodule 19.83 9.94 20 217298 22974 79504096
Burnout syndrome 19.79 9.94 12 217306 324 79526746
Dialysis 19.72 9.94 13 217305 18449 79508621
Lactic acidosis 19.72 9.94 285 217033 70074 79456996
Hallucination, tactile 19.68 9.94 15 217303 594 79526476
Trismus 19.64 9.94 45 217273 5422 79521648
Sleep apnoea syndrome 19.57 9.94 168 217150 36310 79490760
Foaming at mouth 19.57 9.94 25 217293 1872 79525198
Torsade de pointes 19.47 9.94 104 217214 19208 79507862
Chest discomfort 19.44 9.94 262 217056 137782 79389288
Upper respiratory tract infection 19.41 9.94 157 217161 91011 79436059
Enthesopathy 19.36 9.94 4 217314 11604 79515466
Emotional distress 19.35 9.94 180 217138 39789 79487281
Starvation ketoacidosis 19.35 9.94 9 217309 139 79526931
Lip dry 19.15 9.94 9 217309 15409 79511661
Sciatic nerve neuropathy 19.02 9.94 13 217305 433 79526637
Histamine level increased 19.01 9.94 8 217310 96 79526974
Flight of ideas 19.00 9.94 17 217301 845 79526225
Diverticulitis 18.93 9.94 63 217255 45873 79481197
Activation syndrome 18.93 9.94 11 217307 274 79526796
Bipolar II disorder 18.89 9.94 13 217305 438 79526632
Grip strength decreased 18.88 9.94 19 217299 21850 79505220
Pneumonia bacterial 18.84 9.94 15 217303 19316 79507754
Attention deficit hyperactivity disorder 18.83 9.94 33 217285 3276 79523794
Hyperchloraemia 18.78 9.94 19 217299 1102 79525968
Pericardial effusion 18.66 9.94 64 217254 46173 79480897
Abnormal sleep-related event 18.55 9.94 17 217301 872 79526198
Imprisonment 18.49 9.94 14 217304 549 79526521
Asphyxia 18.47 9.94 72 217246 11648 79515422
Gambling 18.41 9.94 11 217307 289 79526781
Increased appetite 18.40 9.94 73 217245 11905 79515165
Stress 18.33 9.94 312 217006 79300 79447770
Rash pruritic 18.33 9.94 117 217201 71512 79455558
Alanine aminotransferase increased 18.32 9.94 322 216996 162248 79364822
Adverse drug reaction 18.27 9.94 106 217212 66286 79460784
Blood calcium decreased 18.21 9.94 37 217281 31782 79495288
Aspartate aminotransferase increased 18.16 9.94 267 217051 138374 79388696
Transient psychosis 18.12 9.94 7 217311 66 79527004
Metastases to bone 18.09 9.94 24 217294 24403 79502667
Pre-eclampsia 18.05 9.94 51 217267 6990 79520080
Localised infection 18.04 9.94 48 217270 37527 79489543
Left ventricular dysfunction 18.00 9.94 102 217216 19259 79507811
Hyperacusis 17.93 9.94 26 217292 2197 79524873
Ulcer 17.89 9.94 34 217284 29938 79497132
Renal disorder 17.87 9.94 57 217261 42048 79485022
Vitamin K decreased 17.85 9.94 7 217311 69 79527001
Osteoarthritis 17.84 9.94 152 217166 87157 79439913
Micturition urgency 17.80 9.94 75 217243 12566 79514504
Hepatic failure 17.78 9.94 96 217222 61116 79465954
Pulmonary contusion 17.78 9.94 8 217310 114 79526956
Eosinophilic pustular folliculitis 17.78 9.94 8 217310 114 79526956
Skin maceration 17.76 9.94 7 217311 70 79527000
CYP3A4 polymorphism 17.76 9.94 7 217311 70 79527000
Orthostatic intolerance 17.75 9.94 24 217294 1900 79525170
Impaired driving ability 17.75 9.94 43 217275 5372 79521698
Blood potassium increased 17.65 9.94 33 217285 29242 79497828
Perinatal depression 17.61 9.94 12 217306 398 79526672
Akinesia 17.53 9.94 32 217286 3280 79523790
Disturbance in sexual arousal 17.51 9.94 10 217308 241 79526829
Productive cough 17.50 9.94 155 217163 88176 79438894
Female sexual dysfunction 17.47 9.94 6 217312 39 79527031
Toxic cardiomyopathy 17.45 9.94 12 217306 404 79526666
Ejaculation delayed 17.40 9.94 9 217309 177 79526893
Food craving 17.35 9.94 22 217296 1635 79525435
Haematocrit decreased 17.35 9.94 97 217221 61215 79465855
Purging 17.34 9.94 6 217312 40 79527030
Clostridium difficile infection 17.28 9.94 59 217259 42626 79484444
Peripheral venous disease 17.27 9.94 11 217307 15898 79511172
Pulmonary mass 17.27 9.94 33 217285 29001 79498069
Sluggishness 17.23 9.94 48 217270 6524 79520546
Priapism 17.21 9.94 38 217280 4467 79522603
Potentiating drug interaction 17.13 9.94 58 217260 8761 79518309
Ataxia 17.13 9.94 122 217196 24917 79502153
False positive investigation result 17.10 9.94 18 217300 1094 79525976
Cerebral haematoma 17.02 9.94 54 217264 7888 79519182
Jaundice 17.02 9.94 81 217237 53268 79473802
Pneumothorax 17.02 9.94 32 217286 28291 79498779
Cerebellar haematoma 16.98 9.94 14 217304 622 79526448
Wrong dose 16.97 9.94 22 217296 1672 79525398
Catecholamines urine increased 16.96 9.94 5 217313 18 79527052
Muscle tightness 16.95 9.94 75 217243 12839 79514231
Incontinence 16.91 9.94 80 217238 14084 79512986
Upper gastrointestinal haemorrhage 16.89 9.94 57 217261 41323 79485747
Dystonia 16.88 9.94 108 217210 21291 79505779
Arachnoid cyst 16.79 9.94 11 217307 341 79526729
Genital hypoaesthesia 16.74 9.94 9 217309 192 79526878
Pneumonia aspiration 16.73 9.94 266 217052 66701 79460369
Normal pressure hydrocephalus 16.73 9.94 13 217305 530 79526540
Inflammation 16.66 9.94 169 217149 93584 79433486
Adverse event 16.64 9.94 96 217222 60118 79466952
Micturition disorder 16.56 9.94 35 217283 3993 79523077
Live birth 16.51 9.94 16 217302 18728 79508342
Fibromyalgia 16.51 9.94 105 217213 64235 79462835
Foot deformity 16.49 9.94 25 217293 24049 79503021
Respiratory tract congestion 16.48 9.94 18 217300 19936 79507134
Anal incontinence 16.43 9.94 95 217223 18073 79508997
Delusional disorder, unspecified type 16.40 9.94 15 217303 767 79526303
Neurological symptom 16.40 9.94 57 217261 8726 79518344
Cold agglutinins positive 16.40 9.94 6 217312 48 79527022
Dysphemia 16.38 9.94 32 217286 3452 79523618
Anticonvulsant drug level above therapeutic 16.33 9.94 18 217300 1153 79525917
Asthma 16.33 9.94 483 216835 134612 79392458
Dyspnoea exertional 16.30 9.94 155 217163 86918 79440152
Pulmonary arterial hypertension 16.22 9.94 33 217285 28333 79498737
Focal dyscognitive seizures 16.20 9.94 32 217286 3480 79523590
Post-traumatic neck syndrome 16.18 9.94 24 217294 2070 79525000
Aspergillus infection 16.14 9.94 17 217301 19144 79507926
Peak expiratory flow rate decreased 16.11 9.94 14 217304 669 79526401
Prescribed overdose 16.09 9.94 166 217152 37717 79489353
Unresponsive to stimuli 16.04 9.94 227 217091 55561 79471509
Drug specific antibody 15.99 9.94 27 217291 2601 79524469
Ocular hyperaemia 15.97 9.94 33 217285 28173 79498897
Blood ethanol increased 15.93 9.94 14 217304 679 79526391
Total lung capacity increased 15.87 9.94 25 217293 2273 79524797
Implant site extravasation 15.81 9.94 15 217303 804 79526266
Exposure via ingestion 15.81 9.94 40 217278 5134 79521936
Indifference 15.77 9.94 10 217308 293 79526777
Acute hepatitis B 15.71 9.94 12 217306 477 79526593
Hypoalbuminaemia 15.69 9.94 21 217297 21276 79505794
Cystitis haemorrhagic 15.64 9.94 3 217315 9169 79517901
Decreased appetite 15.63 9.94 768 216550 341650 79185420
Painful ejaculation 15.60 9.94 4 217314 7 79527063
Oropharyngeal pain 15.60 9.94 207 217111 109146 79417924
Hypotonia 15.59 9.94 73 217245 12797 79514273
Antisocial behaviour 15.46 9.94 14 217304 707 79526363
Inadequate analgesia 15.43 9.94 37 217281 4592 79522478
Sternal fracture 15.41 9.94 26 217292 2504 79524566
Bladder trabeculation 15.40 9.94 6 217312 58 79527012
Myocardial infarction 15.36 9.94 383 216935 183746 79343324
Conversion disorder 15.36 9.94 22 217296 1839 79525231
Herbal interaction 15.22 9.94 12 217306 500 79526570
Escherichia infection 15.16 9.94 16 217302 18001 79509069
Tendonitis 15.15 9.94 26 217292 23804 79503266
Claustrophobia 15.14 9.94 18 217300 1252 79525818
Feeling guilty 15.07 9.94 15 217303 853 79526217
Therapy interrupted 15.07 9.94 40 217278 31301 79495769
Device malfunction 14.96 9.94 22 217296 21426 79505644
Regressive behaviour 14.95 9.94 8 217310 169 79526901
Cerebrovascular accident 14.92 9.94 316 217002 154976 79372094
Drug level above therapeutic 14.91 9.94 55 217263 8668 79518402
Tricuspid valve sclerosis 14.89 9.94 5 217313 30 79527040
Forced expiratory volume decreased 14.84 9.94 51 217267 7763 79519307
Pneumonia fungal 14.79 9.94 6 217312 11204 79515866
Haemorrhage 14.69 9.94 168 217150 90950 79436120
Psychiatric decompensation 14.66 9.94 33 217285 3930 79523140
Rash maculo-papular 14.66 9.94 91 217227 55987 79471083
Bladder cancer 14.65 9.94 19 217299 19507 79507563
Cardiac failure chronic 14.62 9.94 6 217312 11129 79515941
Cerebral vasoconstriction 14.58 9.94 19 217299 1451 79525619
Small intestinal obstruction 14.53 9.94 33 217285 27239 79499831
Ventricular arrhythmia 14.50 9.94 55 217263 8785 79518285
Slow speech 14.48 9.94 25 217293 2453 79524617
Eye pruritus 14.44 9.94 21 217297 20549 79506521
Myopathy 14.43 9.94 21 217297 20542 79506528
Tympanic membrane disorder 14.38 9.94 8 217310 183 79526887
Kidney transplant rejection 14.32 9.94 5 217313 10241 79516829
Parasomnia 14.25 9.94 12 217306 549 79526521
Post-traumatic stress disorder 14.16 9.94 37 217281 4844 79522226
Schizophrenia 14.13 9.94 81 217237 15359 79511711
Generalised oedema 14.06 9.94 27 217291 23682 79503388
Anaemia of pregnancy 14.04 9.94 6 217312 75 79526995
Selective mutism 14.04 9.94 6 217312 75 79526995
Barotrauma 14.04 9.94 8 217310 192 79526878
Parkinsonian gait 13.97 9.94 15 217303 933 79526137
Skin texture abnormal 13.89 9.94 11 217307 461 79526609
Blood catecholamines increased 13.89 9.94 5 217313 38 79527032
Abdominal pain upper 13.81 9.94 485 216833 223334 79303736
Exposure during pregnancy 13.73 9.94 367 216951 100765 79426305
Apallic syndrome 13.71 9.94 15 217303 953 79526117
Anuria 13.69 9.94 101 217217 20862 79506208
Circulatory collapse 13.67 9.94 160 217158 37508 79489562
Multiple sclerosis relapse 13.64 9.94 190 217128 46343 79480727
Wound infection 13.64 9.94 28 217290 23963 79503107
Neurological examination abnormal 13.61 9.94 12 217306 585 79526485
Injection site erythema 13.47 9.94 142 217176 78055 79449015
Injection site pain 13.43 9.94 261 217057 129577 79397493
Alcohol poisoning 13.43 9.94 36 217282 4785 79522285
Sinus rhythm 13.39 9.94 14 217304 844 79526226
Accident at work 13.39 9.94 16 217302 1119 79525951
Alcohol use 13.38 9.94 36 217282 4795 79522275
Violence-related symptom 13.38 9.94 13 217305 718 79526352
Flashback 13.30 9.94 9 217309 295 79526775
Metastases to lung 13.29 9.94 18 217300 18145 79508925
Metastases to central nervous system 13.27 9.94 15 217303 16360 79510710
Salivary hypersecretion 13.27 9.94 75 217243 14149 79512921
Wrong technique in product usage process 13.20 9.94 133 217185 73742 79453328
Blood glucose increased 13.18 9.94 227 217091 114748 79412322
Antineutrophil cytoplasmic antibody positive 13.14 9.94 17 217301 1289 79525781
Hypoxia 13.11 9.94 200 217118 103043 79424027
Full blood count decreased 13.07 9.94 34 217284 26785 79500285
Joint effusion 13.03 9.94 18 217300 17996 79509074
Myasthenia gravis 13.03 9.94 6 217312 10393 79516677
Accidental overdose 13.01 9.94 165 217153 39416 79487654
Appendicitis 12.93 9.94 23 217295 20771 79506299
Disseminated intravascular coagulation 12.90 9.94 52 217266 35790 79491280
Peritonitis bacterial 12.82 9.94 5 217313 9562 79517508
Movement disorder 12.82 9.94 122 217196 27137 79499933
Limited symptom panic attack 12.78 9.94 5 217313 49 79527021
Loose tooth 12.72 9.94 27 217291 3090 79523980
Orgasmic sensation decreased 12.69 9.94 5 217313 50 79527020
Medication overuse headache 12.69 9.94 14 217304 898 79526172
Sickle cell anaemia with crisis 12.67 9.94 3 217315 7919 79519151
Skull fractured base 12.61 9.94 9 217309 322 79526748
Hypnopompic hallucination 12.60 9.94 6 217312 98 79526972
Poor personal hygiene 12.53 9.94 11 217307 533 79526537
Exposure via transplant 12.52 9.94 4 217314 20 79527050
Device leakage 12.50 9.94 7 217311 10849 79516221
Pseudophaeochromocytoma 12.49 9.94 6 217312 100 79526970
Ideas of reference 12.47 9.94 7 217311 163 79526907
Oesophagitis 12.45 9.94 30 217288 24259 79502811
Substance use 12.41 9.94 14 217304 920 79526150
Aplasia pure red cell 12.41 9.94 3 217315 7807 79519263
Angle closure glaucoma 12.40 9.94 26 217292 2950 79524120
Partner stress 12.39 9.94 9 217309 331 79526739
Hypervolaemia 12.37 9.94 67 217251 42623 79484447
Squamous cell carcinoma of skin 12.34 9.94 12 217306 14021 79513049
Device difficult to use 12.29 9.94 11 217307 13374 79513696
Ventricular hypokinesia 12.26 9.94 54 217264 9225 79517845
Status epilepticus 12.24 9.94 113 217205 24928 79502142
Pseudomonas infection 12.22 9.94 24 217294 20879 79506191
Pallor 12.19 9.94 83 217235 49979 79477091
Deja vu 12.19 9.94 5 217313 56 79527014
Ligament pain 12.16 9.94 8 217310 250 79526820
Femur fracture 12.14 9.94 59 217259 38593 79488477
Staring 12.08 9.94 24 217294 2621 79524449
Extrasystoles 12.03 9.94 46 217272 7373 79519697
Dreamy state 12.03 9.94 5 217313 58 79527012
Premature delivery 12.02 9.94 29 217289 23438 79503632
Facet joint syndrome 12.02 9.94 8 217310 11294 79515776
Conjunctivitis viral 12.02 9.94 8 217310 255 79526815
Lip and/or oral cavity cancer 12.01 9.94 15 217303 1098 79525972
Agoraphobia 11.95 9.94 11 217307 567 79526503
CYP2D6 polymorphism 11.95 9.94 5 217313 59 79527011
Head injury 11.95 9.94 155 217163 37214 79489856
May-Thurner syndrome 11.91 9.94 4 217314 24 79527046
Morbihan disease 11.91 9.94 4 217314 24 79527046
Urinary tract infection 11.88 9.94 619 216699 273893 79253177
Device occlusion 11.83 9.94 9 217309 11857 79515213
Bipolar I disorder 11.82 9.94 21 217297 2108 79524962
Grandiosity 11.81 9.94 11 217307 576 79526494
Respiratory acidosis 11.76 9.94 61 217257 11139 79515931
Blood lactic acid increased 11.76 9.94 67 217251 12677 79514393
Blood pressure increased 11.75 9.94 696 216622 210664 79316406
Consciousness fluctuating 11.68 9.94 20 217298 1949 79525121
Aortic stenosis 11.67 9.94 3 217315 7492 79519578
Judgement impaired 11.67 9.94 16 217302 1284 79525786
Facial nerve disorder 11.67 9.94 12 217306 710 79526360
Rales 11.66 9.94 23 217295 19978 79507092
Fear of injection 11.62 9.94 3 217315 7471 79519599
Hepatocellular carcinoma 11.62 9.94 5 217313 9016 79518054
Spasmodic dysphonia 11.61 9.94 8 217310 270 79526800
Hypnagogic hallucination 11.61 9.94 7 217311 187 79526883
Neuropsychiatric syndrome 11.60 9.94 6 217312 118 79526952
Obsessive-compulsive symptom 11.55 9.94 7 217311 189 79526881
Pleural rub 11.52 9.94 5 217313 65 79527005
Pancreatic carcinoma 11.49 9.94 12 217306 13565 79513505
Labour complication 11.46 9.94 6 217312 121 79526949
Hyponatraemic coma 11.45 9.94 5 217313 66 79527004
Chronic kidney disease 11.45 9.94 120 217198 66034 79461036
Magical thinking 11.44 9.94 3 217315 6 79527064
Gun shot wound 11.42 9.94 15 217303 1155 79525915
Encephalopathy 11.39 9.94 252 217066 67145 79459925
Chills 11.36 9.94 341 216977 159893 79367177
Radius fracture 11.36 9.94 28 217290 3536 79523534
Vascular device infection 11.30 9.94 7 217311 10269 79516801
Drug resistance 11.29 9.94 68 217250 42145 79484925
Antiphospholipid antibodies 11.29 9.94 6 217312 125 79526945
Infective pulmonary exacerbation of cystic fibrosis 11.28 9.94 11 217307 12840 79514230
Impaired work ability 11.28 9.94 92 217226 19589 79507481
Anaphylactic shock 11.28 9.94 55 217263 35941 79491129
Withdrawal catatonia 11.26 9.94 7 217311 198 79526872
Polyarthritis 11.24 9.94 10 217308 12192 79514878
Central nervous system necrosis 11.24 9.94 8 217310 285 79526785
Atrioventricular block 11.23 9.94 13 217305 14028 79513042
Feeling of body temperature change 11.22 9.94 36 217282 5290 79521780
Drug withdrawal convulsions 11.18 9.94 21 217297 2199 79524871
Snoring 11.16 9.94 37 217281 5529 79521541
Multiple-drug resistance 11.16 9.94 5 217313 8803 79518267
Hypoglycaemia 11.15 9.94 359 216959 101235 79425835
Skin disorder 11.14 9.94 51 217267 33892 79493178
Large intestine perforation 11.11 9.94 14 217304 14553 79512517
Dry skin 11.10 9.94 125 217193 67870 79459200
Stevens-Johnson syndrome 11.06 9.94 62 217256 39104 79487966
Pseudohyponatraemia 11.04 9.94 6 217312 131 79526939
Renal aplasia 11.00 9.94 6 217312 132 79526938
Thunderclap headache 10.99 9.94 9 217309 396 79526674
Arrhythmia 10.96 9.94 231 217087 61041 79466029
Cholestatic liver injury 10.96 9.94 34 217284 4907 79522163
Cartilage injury 10.95 9.94 17 217301 1526 79525544
Humidity intolerance 10.95 9.94 9 217309 398 79526672
Creutzfeldt-Jakob disease 10.95 9.94 7 217311 208 79526862
Temperature regulation disorder 10.94 9.94 38 217280 5815 79521255
Respiratory syncytial virus infection 10.91 9.94 6 217312 9396 79517674
Eosinophilic myocarditis 10.91 9.94 15 217303 1207 79525863
Knee arthroplasty 10.88 9.94 71 217247 43177 79483893
Therapeutic response decreased 10.87 9.94 123 217195 66730 79460340
Blood triglycerides increased 10.82 9.94 96 217222 20944 79506126
Musculoskeletal pain 10.81 9.94 205 217113 102149 79424921
Wheezing 10.74 9.94 239 217079 116425 79410645
Patella fracture 10.73 9.94 19 217299 1902 79525168
Skin reaction 10.71 9.94 17 217301 16051 79511019
Hypotonia neonatal 10.71 9.94 5 217313 78 79526992
Marital problem 10.69 9.94 7 217311 217 79526853
Disorganised speech 10.63 9.94 20 217298 2097 79524973
Back pain 10.63 9.94 700 216618 303480 79223590
Intestinal anastomosis complication 10.63 9.94 8 217310 311 79526759
Stereotypy 10.62 9.94 13 217305 932 79526138
Bladder dilatation 10.62 9.94 20 217298 2099 79524971
Gonadotrophin deficiency 10.62 9.94 4 217314 35 79527035
Sleep talking 10.62 9.94 14 217304 1082 79525988
Juvenile myoclonic epilepsy 10.59 9.94 5 217313 80 79526990
Cystic lymphangioma 10.59 9.94 3 217315 9 79527061
Disability 10.59 9.94 19 217299 17101 79509969
Pulmonary vein occlusion 10.56 9.94 6 217312 143 79526927
Pain in jaw 10.51 9.94 78 217240 46073 79480997
Chronic sinusitis 10.49 9.94 12 217306 13014 79514056
Coagulation factor VII level decreased 10.46 9.94 7 217311 225 79526845
Glassy eyes 10.45 9.94 6 217312 146 79526924
Tanning 10.43 9.94 5 217313 83 79526987
Human chorionic gonadotropin positive 10.42 9.94 4 217314 37 79527033
Salivary gland disorder 10.41 9.94 8 217310 321 79526749
Anal fistula 10.40 9.94 3 217315 6941 79520129
Hyperemesis gravidarum 10.38 9.94 9 217309 429 79526641
Mechanical urticaria 10.36 9.94 9 217309 430 79526640
Product formulation issue 10.33 9.94 13 217305 959 79526111
Taste disorder 10.30 9.94 17 217301 15806 79511264
Rectal fissure 10.30 9.94 13 217305 962 79526108
Asthenia 10.29 9.94 1229 216089 510460 79016610
Hyperphagia 10.29 9.94 22 217296 2530 79524540
Renal injury 10.28 9.94 19 217299 16908 79510162
Amniotic fluid volume increased 10.24 9.94 6 217312 152 79526918
Norepinephrine increased 10.22 9.94 5 217313 87 79526983
Tuberculosis 10.20 9.94 16 217302 15182 79511888
Action tremor 10.20 9.94 9 217309 439 79526631
Injection site rash 10.17 9.94 21 217297 17933 79509137
Alpha 2 globulin increased 10.17 9.94 6 217312 154 79526916
Large cell lung cancer metastatic 10.13 9.94 3 217315 11 79527059
Allodynia 10.12 9.94 17 217301 1631 79525439
Generalised anxiety disorder 10.11 9.94 20 217298 2177 79524893
Alcohol withdrawal syndrome 10.10 9.94 19 217299 1992 79525078
Tic 10.10 9.94 24 217294 2962 79524108
Acidosis 10.07 9.94 90 217228 19672 79507398
Granuloma 10.07 9.94 5 217313 8292 79518778
Urinary hesitation 10.07 9.94 30 217288 4236 79522834
Alpha 1 globulin increased 10.06 9.94 5 217313 90 79526980
Platelet aggregation abnormal 10.06 9.94 4 217314 41 79527029
Right ventricular systolic pressure decreased 10.01 9.94 5 217313 91 79526979
Gangrene 10.01 9.94 6 217312 8958 79518112
Bone density decreased 10.00 9.94 13 217305 13334 79513736
Opiates positive 10.00 9.94 13 217305 991 79526079
Device issue 9.96 9.94 39 217279 27069 79500001

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Selective eating disorder 42.74 25.54 91 2038 1137 86526
Premature baby 28.97 25.54 31 2098 3897 83766
Hypotonia neonatal 28.54 25.54 59 2070 717 86946
Mitral valve incompetence 27.87 25.54 12 2117 7 87656
Neonatal asphyxia 27.43 25.54 22 2107 89 87574

Pharmacologic Action:

SourceCodeDescription
ATC N06AX16 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D000068760 Serotonin and Noradrenaline Reuptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:51039 dopamine reuptake inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
FDA EPC N0000175749 Serotonin and Norepinephrine Reuptake Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Social phobia indication 25501002 DOID:11257
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Menopausal flushing off-label use 198436008
Neuropathic pain off-label use 247398009
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperthyroidism contraindication 34486009 DOID:7998
Upper gastrointestinal hemorrhage contraindication 37372002
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Mania contraindication 231494001
Hypomania contraindication 231496004
Interstitial lung disease contraindication 233703007 DOID:3082
Disease of liver contraindication 235856003 DOID:409
Hypertriglyceridemia contraindication 302870006
Serotonin syndrome contraindication 371089000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.05 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 5.98 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 5.70 PDSP
5-hydroxytryptamine receptor 6 GPCR Ki 5.55 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.44 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.65 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.05 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 7.60 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.44 CHEMBL
Transporter Transporter IC50 6.19 CHEMBL
Transporter Transporter Ki 6.86 CHEMBL

External reference:

IDSource
4023901 VUID
N0000021906 NUI
D00821 KEGG_DRUG
99300-78-4 SECONDARY_CAS_RN
4020846 VANDF
4023901 VANDF
C0078569 UMLSCUI
CHEBI:9943 CHEBI
CHEMBL637 ChEMBL_ID
DB00285 DRUGBANK_ID
CHEMBL1201066 ChEMBL_ID
D000069470 MESH_DESCRIPTOR_UI
5656 PUBCHEM_CID
7321 IUPHAR_LIGAND_ID
6358 INN_ID
GRZ5RCB1QG UNII
151692 RXNORM
5669 MMSL
594 MMSL
87651 MMSL
d03181 MMSL
004428 NDDF
004429 NDDF
108432009 SNOMEDCT_US
108434005 SNOMEDCT_US
372490001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0833 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0833 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0833 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0836 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0836 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0836 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0837 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0837 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0837 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 40 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7384 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7384 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7385 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7385 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7386 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7386 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9147 TABLET 25 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9147 TABLET 25 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9148 TABLET 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9148 TABLET 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9149 TABLET 50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9149 TABLET 50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9157 TABLET 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9157 TABLET 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9163 TABLET 100 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9163 TABLET 100 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2604 TABLET 150 mg ORAL ANDA 30 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2605 TABLET 225 mg ORAL ANDA 30 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0527-2606 TABLET 75 mg ORAL ANDA 30 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0527-2606 TABLET 75 mg ORAL ANDA 30 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0527-2616 TABLET 75 mg ORAL ANDA 30 sections