venlafaxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2813 93413-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • venlafaxine
  • (+/-)-Venlafaxine
  • velafax
  • venlafaxin
  • venlafexine
  • venlafaxine hydrochloride
  • effexor
  • WY-45,030
  • venlafaxine HCl
A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
  • Molecular weight: 277.41
  • Formula: C17H27NO2
  • CLOGP: 3.27
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.70
  • ALOGS: -3.08
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 572 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.59 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 45 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 14 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.73 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1993 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1381.53 10.00 1903 176785 131930 55981449
Drug withdrawal syndrome 1213.64 10.00 847 177841 25010 56088369
Intentional overdose 1042.94 10.00 1181 177507 66936 56046443
Serotonin syndrome 866.49 10.00 699 177989 25791 56087588
Suicide attempt 860.19 10.00 988 177700 56848 56056531
Suicidal ideation 851.39 10.00 982 177706 56760 56056619
Toxicity to various agents 750.89 10.00 1971 176717 222593 55890786
Depression 733.29 10.00 1705 176983 178412 55934967
Overdose 590.67 10.00 1140 177548 104690 56008689
Rheumatoid arthritis 556.30 10.00 260 178428 382344 55731035
Intentional self-injury 552.70 10.00 528 178160 24464 56088915
Drug abuse 550.93 10.00 861 177827 66749 56046630
Withdrawal syndrome 489.97 10.00 432 178256 18030 56095349
Drug interaction 446.60 10.00 1572 177116 208183 55905196
Poisoning deliberate 443.50 10.00 316 178372 9637 56103742
Anxiety 411.37 10.00 1448 177240 191724 55921655
Systemic lupus erythematosus 383.96 10.00 57 178631 180021 55933358
Contraindicated product administered 372.72 10.00 70 178618 186216 55927163
Synovitis 370.68 10.00 40 178648 161265 55952114
Hand deformity 365.55 10.00 14 178674 134478 55978901
Joint swelling 354.71 10.00 243 178445 289557 55823822
Agitation 347.71 10.00 632 178056 55404 56057975
Sopor 335.63 10.00 372 178316 20550 56092829
Coma 335.45 10.00 645 178043 59010 56054369
Glossodynia 323.26 10.00 49 178639 152409 55960970
Arthropathy 295.37 10.00 133 178555 200142 55913237
Tremor 287.65 10.00 942 177746 120147 55993232
Pericarditis 284.00 10.00 15 178673 108908 56004471
Mydriasis 271.87 10.00 248 178440 10823 56102556
Crying 267.17 10.00 335 178353 21105 56092274
Infusion related reaction 263.84 10.00 169 178519 208762 55904617
Somnolence 251.08 10.00 1106 177582 162307 55951072
Wound 240.38 10.00 71 178617 138733 55974646
Hyperhidrosis 236.12 10.00 746 177942 93342 56020037
Alopecia 234.99 10.00 355 178333 293103 55820276
Electrocardiogram QT prolonged 225.06 10.00 520 178168 54068 56059311
Swelling 224.71 10.00 258 178430 239513 55873866
Rash 220.53 10.00 814 177874 492233 55621146
Treatment failure 212.11 10.00 140 178548 170252 55943127
Abdominal discomfort 210.97 10.00 347 178341 276927 55836452
Seizure 208.42 10.00 868 177820 124251 55989128
Hypersensitivity 202.50 10.00 313 178375 256095 55857284
Helicobacter infection 197.76 10.00 8 178680 73260 56040119
Discomfort 188.19 10.00 108 178580 141653 55971726
Akathisia 180.33 10.00 177 178511 8475 56104904
Irritability 176.26 10.00 328 178360 29260 56084119
Selective eating disorder 175.54 10.00 96 178592 1808 56111571
Panic attack 167.22 10.00 261 178427 20186 56093193
Depressed mood 166.25 10.00 361 178327 35998 56077381
Disturbance in attention 166.14 10.00 338 178350 32202 56081177
Nightmare 165.19 10.00 234 178454 16592 56096787
Infection 161.27 10.00 241 178447 199965 55913414
Anger 161.00 10.00 192 178496 11480 56101899
Therapeutic product effect decreased 157.94 10.00 183 178505 169269 55944110
Hypotonia neonatal 157.00 10.00 75 178613 1049 56112330
Feeling abnormal 154.58 10.00 834 177854 132768 55980611
Off label use 148.70 10.00 1095 177593 555085 55558294
Drug intolerance 147.09 10.00 396 178292 264422 55848957
Pain 145.57 10.00 1376 177312 661808 55451571
Restlessness 141.51 10.00 281 178407 26305 56087074
Muscle injury 137.53 10.00 7 178681 52493 56060886
Aggression 136.17 10.00 248 178440 21758 56091621
Hepatic enzyme increased 134.44 10.00 210 178478 171174 55942205
Generalised tonic-clonic seizure 129.80 10.00 277 178411 27289 56086090
Foetal exposure during pregnancy 129.39 10.00 313 178375 33510 56079869
Arthralgia 127.23 10.00 1002 177686 500667 55612712
Cardiac arrest 126.97 10.00 577 178111 85737 56027642
Drug dependence 125.80 10.00 243 178445 22290 56091089
Product substitution issue 124.49 10.00 190 178498 14409 56098970
Product use issue 124.26 10.00 252 178436 185789 55927590
Blister 121.79 10.00 100 178588 108787 56004592
Major depression 120.15 10.00 134 178554 7450 56105929
Febrile neutropenia 119.20 10.00 96 178592 105449 56007930
Tachycardia 119.11 10.00 656 178032 105220 56008159
Peripheral swelling 118.60 10.00 367 178321 234359 55879020
Folliculitis 118.00 10.00 17 178671 54962 56058417
Sleep disorder due to general medical condition, insomnia type 112.82 10.00 6 178682 43332 56070047
Pneumonia 112.72 10.00 793 177895 406305 55707074
Disorientation 112.43 10.00 312 178376 36301 56077078
Cardio-respiratory arrest 111.71 10.00 408 178280 54913 56058466
Respiratory arrest 109.31 10.00 276 178412 30349 56083030
Pyrexia 108.62 10.00 831 177857 417942 55695437
Impaired healing 105.78 10.00 73 178615 86768 56026611
Gestational diabetes 103.65 10.00 128 178560 7936 56105443
Stomatitis 103.59 10.00 139 178549 120671 55992708
Poisoning 99.85 10.00 160 178528 12653 56100726
Muscle rigidity 98.30 10.00 144 178544 10527 56102852
Psychomotor hyperactivity 97.03 10.00 137 178551 9683 56103696
Nasopharyngitis 97.00 10.00 367 178321 220592 55892787
Drug withdrawal syndrome neonatal 96.76 10.00 67 178621 1949 56111430
Small for dates baby 96.43 10.00 84 178604 3446 56109933
Extrapyramidal disorder 95.89 10.00 154 178534 12202 56101177
Insomnia 95.12 10.00 979 177709 190881 55922498
Mania 94.12 10.00 147 178541 11373 56102006
Mood swings 93.97 10.00 181 178507 16566 56096813
Tearfulness 91.71 10.00 84 178604 3684 56109695
Abnormal dreams 91.49 10.00 132 178556 9517 56103862
Hyperreflexia 90.54 10.00 97 178591 5153 56108226
Atrial septal defect 89.69 10.00 107 178581 6399 56106980
Maternal exposure during pregnancy 89.04 10.00 306 178382 189247 55924132
Sleep-related eating disorder 86.70 10.00 45 178643 759 56112620
Mental disorder 86.62 10.00 215 178473 23389 56089990
Paraesthesia 85.93 10.00 708 177980 129806 55983573
Mobility decreased 84.75 10.00 114 178574 98877 56014502
Amnesia 83.09 10.00 329 178359 45993 56067386
Sepsis 83.02 10.00 202 178486 139638 55973741
Irritable bowel syndrome 82.77 10.00 58 178630 68400 56044979
Foetal death 82.19 10.00 118 178570 8469 56104910
C-reactive protein abnormal 79.88 10.00 11 178677 36798 56076581
Hallucination 79.42 10.00 338 178350 48811 56064568
Newborn persistent pulmonary hypertension 78.38 10.00 29 178659 202 56113177
Altered state of consciousness 77.53 10.00 203 178485 22818 56090561
Antidepressant drug level increased 77.20 10.00 30 178658 243 56113136
Platelet count decreased 76.31 10.00 138 178550 106245 56007134
Anaemia 75.93 10.00 517 178171 266994 55846385
Musculoskeletal stiffness 74.50 10.00 250 178438 155757 55957622
Camptocormia 74.36 10.00 30 178658 271 56113108
Decorticate posture 74.17 10.00 30 178658 273 56113106
Ill-defined disorder 74.11 10.00 65 178623 68478 56044901
Intentional product misuse 74.00 10.00 342 178346 51162 56062217
Homicide 73.79 10.00 32 178656 352 56113027
Psoriatic arthropathy 73.23 10.00 76 178612 73932 56039447
Stress cardiomyopathy 73.21 10.00 110 178578 8226 56105153
Migraine 73.04 10.00 499 178189 86298 56027081
Myocardial depression 72.50 10.00 34 178654 455 56112924
Sinusitis 72.08 10.00 352 178336 197229 55916150
Dizziness 70.98 10.00 1627 177061 374513 55738866
Nervousness 70.82 10.00 228 178460 28787 56084592
Mental impairment 69.55 10.00 136 178552 12586 56100793
Galactorrhoea 69.00 10.00 73 178615 3822 56109557
Lower respiratory tract infection 68.78 10.00 165 178523 114629 55998750
Antidepressant drug level above therapeutic 68.37 10.00 31 178657 382 56112997
Hip arthroplasty 68.21 10.00 19 178669 38604 56074775
Vertigo 68.08 10.00 348 178340 54224 56059155
Thinking abnormal 67.90 10.00 117 178571 9824 56103555
Tardive dyskinesia 67.73 10.00 104 178584 7927 56105452
Confusional state 67.73 10.00 981 177707 207174 55906205
Lung diffusion test abnormal 66.82 10.00 27 178661 245 56113134
Abnormal behaviour 66.48 10.00 177 178511 20095 56093284
Self-injurious ideation 66.38 10.00 57 178631 2293 56111086
Electrocardiogram QRS complex prolonged 65.83 10.00 84 178604 5383 56107996
Neutropenia 64.74 10.00 270 178418 157897 55955482
Thrombocytopenia 64.55 10.00 219 178469 136005 55977374
Psychomotor retardation 63.64 10.00 68 178620 3601 56109778
Cataplexy 63.33 10.00 44 178644 1287 56112092
Neonatal seizure 62.83 10.00 30 178658 419 56112960
Disease progression 61.56 10.00 153 178535 105020 56008359
Loss of consciousness 61.47 10.00 573 178115 108776 56004603
Cardiogenic shock 60.22 10.00 149 178539 16176 56097203
Physical assault 60.02 10.00 37 178651 879 56112500
Muscle twitching 59.65 10.00 148 178540 16094 56097285
Bipolar disorder 59.54 10.00 95 178593 7485 56105894
Myoclonus 58.46 10.00 141 178547 15062 56098317
Large for dates baby 58.02 10.00 29 178659 450 56112929
Inappropriate affect 57.44 10.00 35 178653 814 56112565
Respiratory depression 57.43 10.00 124 178564 12311 56101068
Pleurothotonus 56.68 10.00 41 178647 1280 56112099
Impulsive behaviour 56.22 10.00 43 178645 1464 56111915
Drug screen false positive 55.98 10.00 34 178654 786 56112593
Sedation 54.99 10.00 238 178450 34616 56078763
Hot flush 54.85 10.00 293 178395 46433 56066946
Apathy 54.83 10.00 94 178594 7860 56105519
Congenital tricuspid valve incompetence 54.65 10.00 18 178670 84 56113295
Sinus tachycardia 54.44 10.00 176 178512 22268 56091111
Bruxism 53.72 10.00 58 178630 3108 56110271
Homicidal ideation 53.55 10.00 44 178644 1664 56111715
Renal impairment 53.26 10.00 110 178578 80603 56032776
Malignant neoplasm progression 53.17 10.00 95 178593 73492 56039887
Neonatal hypoxia 53.13 10.00 28 178660 488 56112891
Lymphocytic oesophagitis 52.86 10.00 13 178675 13 56113366
Self esteem decreased 52.79 10.00 29 178659 551 56112828
Hallucination, visual 52.77 10.00 148 178540 17320 56096059
Mood altered 52.58 10.00 125 178563 13230 56100149
Drug ineffective 51.99 10.00 2388 176300 916601 55196778
Meconium in amniotic fluid 51.88 10.00 22 178666 228 56113151
Depressive symptom 51.74 10.00 60 178628 3481 56109898
Nystagmus 51.35 10.00 77 178611 5748 56107631
Tinnitus 51.18 10.00 210 178478 29832 56083547
Parkinsonism 50.91 10.00 101 178587 9445 56103934
Benzodiazepine drug level increased 50.84 10.00 20 178668 168 56113211
Plasma cell myeloma 50.71 10.00 44 178644 46602 56066777
Psychotic disorder 50.31 10.00 177 178511 23381 56089998
Gastrointestinal disorder 50.17 10.00 186 178502 112516 56000863
Product residue present 50.00 10.00 61 178627 3734 56109645
Libido decreased 49.69 10.00 49 178639 2359 56111020
Patent ductus arteriosus 49.63 10.00 62 178626 3889 56109490
General physical health deterioration 49.47 10.00 326 178362 169684 55943695
Haemoglobin decreased 49.45 10.00 238 178450 133899 55979480
Urinary incontinence 48.98 10.00 205 178483 29380 56083999
Hostility 48.87 10.00 43 178645 1788 56111591
Memory impairment 48.85 10.00 454 178234 86103 56027276
Neonatal asphyxia 48.39 10.00 22 178666 273 56113106
Neuroleptic malignant syndrome 48.00 10.00 110 178578 11368 56102011
Suicidal behaviour 47.42 10.00 48 178640 2385 56110994
Somnambulism 47.31 10.00 69 178619 5023 56108356
Emotional disorder 47.24 10.00 114 178574 12181 56101198
Neonatal respiratory failure 47.18 10.00 21 178667 247 56113132
Red blood cell sedimentation rate increased 47.01 10.00 29 178659 36594 56076785
Coma scale abnormal 46.80 10.00 67 178621 4796 56108583
Dissociation 46.77 10.00 49 178639 2536 56110843
Feeling of despair 46.65 10.00 45 178643 2108 56111271
Bezoar 46.62 10.00 37 178651 1331 56112048
Hallucination, auditory 46.61 10.00 109 178579 11415 56101964
Weight increased 46.51 10.00 1004 177684 228699 55884680
Accommodation disorder 46.48 10.00 23 178665 349 56113030
Dyspnoea 46.37 10.00 1481 177207 591096 55522283
Paranoia 46.07 10.00 104 178584 10640 56102739
Neovascularisation 46.02 10.00 33 178655 1016 56112363
Knee arthroplasty 45.44 10.00 44 178644 44215 56069164
Diarrhoea 45.02 10.00 1617 177071 636890 55476489
Euphoric mood 44.84 10.00 62 178626 4296 56109083
Delusion 44.18 10.00 105 178583 11110 56102269
C-reactive protein increased 44.09 10.00 117 178571 78567 56034812
Anticholinergic syndrome 43.00 10.00 41 178647 1893 56111486
Opsoclonus myoclonus 42.99 10.00 17 178671 145 56113234
Anorgasmia 42.66 10.00 25 178663 540 56112839
Hypersomnia 42.25 10.00 131 178557 16210 56097169
Hypomania 42.07 10.00 64 178624 4838 56108541
Hypothermia 42.03 10.00 110 178578 12360 56101019
Pancytopenia 41.76 10.00 143 178545 88572 56024807
Panic reaction 41.70 10.00 56 178632 3774 56109605
Drug hypersensitivity 41.62 10.00 1156 177532 274049 55839330
Single umbilical artery 41.56 10.00 19 178669 239 56113140
Restless legs syndrome 41.20 10.00 133 178555 16814 56096565
Personality disorder 40.86 10.00 65 178623 5108 56108271
Dyskinesia 40.85 10.00 192 178496 28916 56084463
Lung disorder 40.67 10.00 65 178623 52532 56060847
Death 40.52 10.00 802 177886 340624 55772755
Alcohol interaction 40.04 10.00 43 178645 2290 56111089
Transient tachypnoea of the newborn 39.20 10.00 15 178673 116 56113263
Intentional product use issue 39.10 10.00 173 178515 99560 56013819
Malignant mediastinal neoplasm 38.63 10.00 28 178660 877 56112502
Pneumocystis jirovecii pneumonia 38.42 10.00 3 178685 15698 56097681
Myelosuppression 38.39 10.00 5 178683 17450 56095929
Bipolar II disorder 37.78 10.00 19 178669 299 56113080
Anaphylactic reaction 37.58 10.00 82 178606 58913 56054466
Atrial fibrillation 37.40 10.00 198 178490 108699 56004680
Persistent genital arousal disorder 37.33 10.00 19 178669 307 56113072
Oedema 37.24 10.00 134 178554 81786 56031593
Congenital vesicoureteric reflux 36.64 10.00 10 178678 20 56113359
Rapid eye movement sleep behaviour disorder 36.11 10.00 16 178672 186 56113193
VACTERL syndrome 36.11 10.00 9 178679 10 56113369
Full blood count abnormal 36.01 10.00 173 178515 26289 56087090
Pain in extremity 35.78 10.00 697 177991 296734 55816645
Skin candida 35.70 10.00 32 178656 1364 56112015
Ventricular septal defect 35.48 10.00 54 178634 4084 56109295
Hyponatraemia 35.43 10.00 487 178201 101652 56011727
Fluid retention 35.42 10.00 74 178614 54004 56059375
Bradycardia neonatal 35.41 10.00 26 178662 831 56112548
Libido increased 35.39 10.00 31 178657 1281 56112098
Drug screen positive 35.22 10.00 49 178639 3415 56109964
Congenital hearing disorder 35.22 10.00 9 178679 12 56113367
Adverse drug reaction 34.88 10.00 99 178589 65033 56048346
Pulmonary haemorrhage neonatal 34.83 10.00 10 178678 26 56113353
Amniorrhexis 34.83 10.00 10 178678 26 56113353
Negative thoughts 34.64 10.00 26 178662 860 56112519
Psychotic symptom 34.26 10.00 31 178657 1338 56112041
Neonatal respiratory distress syndrome 34.25 10.00 43 178645 2711 56110668
Speech disorder 34.21 10.00 220 178468 37273 56076106
Pruritus 33.95 10.00 756 177932 315867 55797512
Adjustment disorder with mixed anxiety and depressed mood 33.67 10.00 12 178676 74 56113305
Renal papillary necrosis 33.67 10.00 16 178672 221 56113158
Bone erosion 33.64 10.00 4 178684 14970 56098409
Gastrointestinal haemorrhage 33.37 10.00 126 178562 75825 56037554
Tonic convulsion 33.37 10.00 29 178659 1186 56112193
Rheumatoid nodule 33.30 10.00 4 178684 14853 56098526
Asphyxia 33.00 10.00 63 178625 5726 56107653
Endometriosis 32.98 10.00 56 178632 4646 56108733
Logorrhoea 32.94 10.00 39 178649 2313 56111066
Postmortem blood drug level abnormal 32.82 10.00 18 178670 341 56113038
Panic disorder 32.75 10.00 40 178648 2451 56110928
Yawning 32.75 10.00 27 178661 1026 56112353
Burnout syndrome 32.58 10.00 15 178673 192 56113187
Agitation neonatal 32.15 10.00 20 178668 483 56112896
Blood creatinine increased 32.10 10.00 138 178550 80053 56033326
Vitamin K decreased 32.05 10.00 8 178680 9 56113370
Pleural effusion 31.88 10.00 151 178537 85329 56028050
Hypoventilation neonatal 31.74 10.00 9 178679 22 56113357
Parkinsonism hyperpyrexia syndrome 31.61 10.00 13 178675 124 56113255
Brain death 31.54 10.00 43 178645 2940 56110439
Somatic symptom disorder 31.45 10.00 36 178652 2059 56111320
Nervous system disorder 31.12 10.00 121 178567 16768 56096611
Reversible cerebral vasoconstriction syndrome 30.98 10.00 38 178650 2339 56111040
Leukopenia 30.96 10.00 118 178570 70822 56042557
Loss of libido 30.95 10.00 28 178660 1208 56112171
Herpes zoster 30.74 10.00 130 178558 75759 56037620
Total lung capacity increased 30.69 10.00 25 178663 934 56112445
White blood cell count decreased 30.69 10.00 254 178434 125736 55987643
Injection site pain 30.43 10.00 232 178456 116886 55996493
Tic 30.28 10.00 28 178660 1243 56112136
False positive investigation result 30.12 10.00 20 178668 542 56112837
Tachyphrenia 30.04 10.00 28 178660 1256 56112123
Joint range of motion decreased 29.98 10.00 22 178666 25343 56088036
Neonatal behavioural syndrome 29.80 10.00 10 178678 50 56113329
Hypotonia 29.71 10.00 77 178611 8600 56104779
Respiratory tract inflammation 29.52 10.00 20 178668 561 56112818
Electrocardiogram QRS complex shortened 29.49 10.00 18 178670 420 56112959
Cold sweat 29.48 10.00 89 178599 10854 56102525
Hospitalisation 29.45 10.00 130 178558 74870 56038509
Erythema 29.28 10.00 335 178353 155604 55957775
Substance abuse 29.27 10.00 52 178636 4473 56108906
Haemangioma congenital 29.19 10.00 18 178670 428 56112951
Bone marrow failure 29.17 10.00 28 178660 28258 56085121
Drug tolerance decreased 29.12 10.00 4 178684 13407 56099972
Impaired driving ability 29.02 10.00 49 178639 4047 56109332
Clonus 29.00 10.00 50 178638 4199 56109180
Palpitations 28.98 10.00 461 178227 99211 56014168
Exposure via breast milk 28.67 10.00 32 178656 1780 56111599
Delirium 28.67 10.00 232 178456 42285 56071094
Feelings of worthlessness 28.67 10.00 16 178672 314 56113065
Endolymphatic hydrops 28.54 10.00 6 178682 0 56113379
Social avoidant behaviour 28.49 10.00 40 178648 2812 56110567
Psychiatric symptom 27.97 10.00 53 178635 4791 56108588
Dysarthria 27.87 10.00 218 178470 39332 56074047
Emotional poverty 27.79 10.00 16 178672 334 56113045
Middle insomnia 27.59 10.00 87 178601 10863 56102516
Toxic epidermal necrolysis 27.54 10.00 18 178670 22024 56091355
Cardiotoxicity 27.35 10.00 69 178619 7581 56105798
Congenital absence of bile ducts 27.28 10.00 8 178680 23 56113356
Drug eruption 27.16 10.00 25 178663 25738 56087641
Neuropathy peripheral 27.12 10.00 203 178485 102690 56010689
Injection site erythema 27.05 10.00 140 178548 77308 56036071
Respiratory disorder neonatal 26.87 10.00 23 178665 921 56112458
Congestive cardiomyopathy 26.84 10.00 58 178630 5761 56107618
Epilepsy 26.79 10.00 154 178534 25077 56088302
Frustration tolerance decreased 26.69 10.00 61 178627 6292 56107087
Post-traumatic stress disorder 26.63 10.00 50 178638 4488 56108891
Therapeutic product effect incomplete 26.63 10.00 212 178476 105819 56007560
Victim of sexual abuse 26.30 10.00 19 178669 592 56112787
Hyperprolactinaemia 26.20 10.00 44 178644 3617 56109762
Abnormal weight gain 26.14 10.00 28 178660 1487 56111892
Skin necrosis 26.11 10.00 4 178684 12357 56101022
Food craving 26.08 10.00 28 178660 1491 56111888
Antipsychotic drug level increased 25.97 10.00 41 178647 3201 56110178
Orthostatic intolerance 25.96 10.00 24 178664 1065 56112314
Persistent depressive disorder 25.85 10.00 22 178666 874 56112505
Suspected suicide 25.81 10.00 55 178633 5411 56107968
Enuresis 25.34 10.00 34 178654 2289 56111090
Encephalopathy neonatal 25.32 10.00 7 178681 15 56113364
Feeling jittery 25.28 10.00 90 178598 11956 56101423
Stiff person syndrome 25.15 10.00 15 178673 335 56113044
Erythema dyschromicum perstans 25.05 10.00 9 178679 57 56113322
Encephalopathy 25.05 10.00 195 178493 35130 56078249
Electric shock sensation 24.99 10.00 17 178671 480 56112899
Obstructive airways disorder 24.99 10.00 115 178573 17167 56096212
Pyramidal tract syndrome 24.96 10.00 15 178673 340 56113039
Impaired work ability 24.93 10.00 102 178586 14470 56098909
Paradoxical drug reaction 24.84 10.00 44 178644 3776 56109603
Upper respiratory tract infection 24.82 10.00 129 178559 71159 56042220
Femur fracture 24.71 10.00 55 178633 39240 56074139
Slow response to stimuli 24.46 10.00 22 178666 942 56112437
Obsessive thoughts 24.30 10.00 17 178671 503 56112876
Tenosynovitis 24.22 10.00 5 178683 12456 56100923
Derealisation 24.19 10.00 23 178665 1058 56112321
ECG P wave inverted 23.78 10.00 5 178683 0 56113379
Incoherent 23.77 10.00 46 178642 4223 56109156
Affective disorder 23.76 10.00 54 178634 5549 56107830
Phagophobia 23.68 10.00 8 178680 41 56113338
Tension 23.45 10.00 37 178651 2887 56110492
Antisocial behaviour 23.31 10.00 14 178674 317 56113062
Inappropriate antidiuretic hormone secretion 23.30 10.00 96 178592 13660 56099719
Attention deficit hyperactivity disorder 23.27 10.00 35 178653 2619 56110760
Drug use disorder 23.23 10.00 48 178640 4621 56108758
Schizophreniform disorder 23.15 10.00 9 178679 73 56113306
Starvation ketoacidosis 23.15 10.00 9 178679 73 56113306
Colitis microscopic 23.08 10.00 66 178622 7809 56105570
Consciousness fluctuating 23.07 10.00 19 178669 721 56112658
Coma acidotic 23.06 10.00 10 178678 110 56113269
HELLP syndrome 23.04 10.00 21 178667 915 56112464
Fall 22.99 10.00 1370 177318 356140 55757239
Social anxiety disorder 22.97 10.00 15 178673 395 56112984
Torsade de pointes 22.82 10.00 89 178599 12351 56101028
Pulmonary fibrosis 22.79 10.00 37 178651 29721 56083658
Metabolic syndrome 22.73 10.00 25 178663 1368 56112011
Neonatal hypotension 22.51 10.00 10 178678 117 56113262
Eosinophilic pustular folliculitis 22.31 10.00 7 178681 27 56113352
Hyperacusis 22.24 10.00 29 178659 1899 56111480
Forced expiratory volume decreased 22.13 10.00 47 178641 4613 56108766
Neonatal tachypnoea 22.09 10.00 8 178680 52 56113327
Helplessness 21.97 10.00 13 178675 286 56113093
Septic shock 21.79 10.00 109 178579 60726 56052653
Abulia 21.76 10.00 15 178673 433 56112946
Acute kidney injury 21.66 10.00 590 178098 240173 55873206
Cholestatic liver injury 21.63 10.00 31 178657 2221 56111158
Depressed level of consciousness 21.61 10.00 274 178414 56159 56057220
Congenital pulmonary hypertension 21.59 10.00 8 178680 56 56113323
Tongue biting 21.58 10.00 24 178664 1330 56112049
Affect lability 21.55 10.00 76 178612 10049 56103330
Dyssomnia 21.55 10.00 7 178681 31 56113348
Congenital multiplex arthrogryposis 21.55 10.00 7 178681 31 56113348
Unemployment 21.44 10.00 5 178683 3 56113376
Dependence 21.44 10.00 29 178659 1968 56111411
Blood immunoglobulin E increased 21.32 10.00 36 178652 2973 56110406
Rhabdomyolysis 21.31 10.00 210 178478 40448 56072931
Eye movement disorder 21.26 10.00 47 178641 4742 56108637
Cytomegalovirus infection 21.21 10.00 18 178670 19278 56094101
Osteoporosis 21.18 10.00 89 178599 51963 56061416
Disturbance in sexual arousal 21.16 10.00 9 178679 94 56113285
Drug level increased 21.03 10.00 125 178563 20600 56092779
Bradypnoea 20.96 10.00 37 178651 3166 56110213
Dysphoria 20.91 10.00 47 178641 4795 56108584
Neonatal disorder 20.89 10.00 16 178672 546 56112833
Pneumonia aspiration 20.86 10.00 175 178513 32236 56081143
Blood catecholamines increased 20.79 10.00 6 178682 16 56113363
Antidepressant discontinuation syndrome 20.79 10.00 6 178682 16 56113363
Anhedonia 20.75 10.00 74 178614 9840 56103539
Cough 20.64 10.00 648 178040 259313 55854066
Adverse event 20.54 10.00 98 178590 55278 56058101
Trunk injury 20.53 10.00 6 178682 17 56113362
Ventricular tachycardia 20.53 10.00 107 178581 16794 56096585
Narcolepsy 20.51 10.00 23 178665 1286 56112093
Head discomfort 20.47 10.00 84 178604 11930 56101449
Concussion 20.30 10.00 65 178623 8181 56105198
Acquired amegakaryocytic thrombocytopenia 20.28 10.00 6 178682 18 56113361
Ascites 20.15 10.00 57 178631 37487 56075892
Creutzfeldt-Jakob disease 20.08 10.00 10 178678 154 56113225
Stress 20.06 10.00 280 178408 58630 56054749
Skin maceration 19.94 10.00 7 178681 41 56113338
Soft tissue injury 19.94 10.00 25 178663 1574 56111805
Vision blurred 19.90 10.00 372 178316 82571 56030808
Cytokine release syndrome 19.86 10.00 5 178683 10870 56102509
Dystonia 19.73 10.00 85 178603 12336 56101043
Conversion disorder 19.46 10.00 25 178663 1613 56111766
Creatinine renal clearance decreased 19.43 10.00 11 178677 14548 56098831
Neurodegenerative disorder 19.40 10.00 12 178676 287 56113092
Electrocardiogram ST-T segment abnormal 19.36 10.00 12 178676 288 56113091
Cardiac failure 19.31 10.00 167 178521 81926 56031453
Bundle branch block right 19.30 10.00 45 178643 4702 56108677
Transient psychosis 19.27 10.00 7 178681 46 56113333
Hyperbilirubinaemia neonatal 19.24 10.00 13 178675 363 56113016
Neutrophil count decreased 19.17 10.00 87 178601 49735 56063644
CYP3A4 polymorphism 19.12 10.00 8 178680 80 56113299
Atypical fibroxanthoma 19.02 10.00 4 178684 0 56113379
Neonatal oversedation 19.02 10.00 4 178684 0 56113379
Bradyphrenia 18.94 10.00 55 178633 6565 56106814
Feeling drunk 18.89 10.00 39 178649 3753 56109626
Mucosal inflammation 18.81 10.00 71 178617 42739 56070640
Sciatic nerve neuropathy 18.72 10.00 12 178676 306 56113073
Sluggishness 18.71 10.00 44 178644 4624 56108755
Liver injury 18.65 10.00 69 178619 41779 56071600
Blood triglycerides increased 18.62 10.00 80 178608 11597 56101782
Poor weight gain neonatal 18.61 10.00 8 178680 86 56113293
Feeling guilty 18.61 10.00 15 178673 552 56112827
Nodule 18.55 10.00 19 178669 18600 56094779
Violence-related symptom 18.51 10.00 13 178675 387 56112992
Respiratory tract infection 18.46 10.00 56 178632 36015 56077364
Intestinal strangulation 18.45 10.00 8 178680 88 56113291
Live birth 18.42 10.00 21 178667 19584 56093795
Floppy infant 18.37 10.00 8 178680 89 56113290
Iodine allergy 18.36 10.00 17 178671 756 56112623
Right ventricular failure 18.35 10.00 15 178673 16364 56097015
Hyperkalaemia 18.30 10.00 91 178597 50774 56062605
Cholestasis 18.22 10.00 147 178541 26766 56086613
Cerebral vasoconstriction 18.22 10.00 20 178668 1092 56112287
Hepatic function abnormal 18.15 10.00 53 178635 34505 56078874
Deja vu 18.09 10.00 7 178681 56 56113323
Device expulsion 18.04 10.00 44 178644 30405 56082974
Acute hepatitis B 17.98 10.00 12 178676 328 56113051
Fear 17.84 10.00 94 178594 14814 56098565
Cardiomyopathy 17.76 10.00 100 178588 16158 56097221
Drug ineffective for unapproved indication 17.76 10.00 141 178547 25552 56087827
Depression suicidal 17.68 10.00 24 178664 1634 56111745
Drug specific antibody 17.63 10.00 27 178661 2053 56111326
Anticonvulsant drug level above therapeutic 17.49 10.00 14 178674 510 56112869
Dropped head syndrome 17.47 10.00 8 178680 101 56113278
Oedema peripheral 17.45 10.00 412 178276 170842 55942537
Upper gastrointestinal haemorrhage 17.45 10.00 17 178671 17037 56096342
Troponin abnormal 17.41 10.00 6 178682 33 56113346
Hypercalcaemia 17.30 10.00 34 178654 25377 56088002
Acute myeloid leukaemia 17.27 10.00 17 178671 16955 56096424
Cerebral infarction 17.22 10.00 28 178660 22477 56090902
Trismus 17.03 10.00 36 178652 3522 56109857
Skin ulcer 16.99 10.00 64 178624 38544 56074835
Persistent left superior vena cava 16.97 10.00 6 178682 36 56113343
Fatigue 16.88 10.00 2220 176468 786332 55327047
Cold agglutinins positive 16.84 10.00 6 178682 37 56113342
Psychiatric decompensation 16.81 10.00 21 178667 1317 56112062
Splenic infarction 16.80 10.00 23 178665 1579 56111800
Platelet aggregation abnormal 16.79 10.00 4 178684 3 56113376
Facial nerve disorder 16.78 10.00 14 178674 541 56112838
Alcohol use 16.76 10.00 26 178662 1999 56111380
Sleep terror 16.76 10.00 16 178672 740 56112639
Pulmonary arterial hypertension 16.74 10.00 37 178651 26466 56086913
Diverticulitis 16.72 10.00 58 178630 35794 56077585
Hypnopompic hallucination 16.70 10.00 6 178682 38 56113341
Hypocalcaemia 16.69 10.00 42 178646 28718 56084661
Bacteraemia 16.68 10.00 15 178673 15616 56097763
Loose tooth 16.66 10.00 34 178654 3244 56110135
Cystic lymphangioma 16.66 10.00 5 178683 16 56113363
Movement disorder 16.51 10.00 111 178577 19087 56094292
Alcoholism 16.42 10.00 27 178661 2182 56111197
Neurological examination abnormal 16.39 10.00 10 178678 233 56113146
Congenital uterine anomaly 16.37 10.00 8 178680 118 56113261
Retinal detachment 16.34 10.00 46 178642 5395 56107984
Palmar-plantar erythrodysaesthesia syndrome 16.31 10.00 26 178662 21039 56092340
Emotional distress 16.22 10.00 155 178533 29608 56083771
Therapy non-responder 16.18 10.00 121 178567 61234 56052145
Pre-existing condition improved 16.15 10.00 56 178632 7342 56106037
Oropharyngeal pain 16.11 10.00 179 178509 83609 56029770
Female sexual dysfunction 16.07 10.00 6 178682 43 56113336
Poor personal hygiene 16.04 10.00 11 178677 315 56113064
Akinesia 16.03 10.00 22 178666 1514 56111865
Incontinence 15.94 10.00 72 178616 10663 56102716
Bipolar I disorder 15.85 10.00 23 178665 1667 56111712
Post-traumatic neck syndrome 15.82 10.00 25 178663 1953 56111426
Tumour lysis syndrome 15.77 10.00 3 178685 7920 56105459
Transfusion 15.63 10.00 12 178676 13508 56099871
Central nervous system necrosis 15.62 10.00 8 178680 131 56113248
Peak expiratory flow rate decreased 15.55 10.00 14 178674 600 56112779
Tremor neonatal 15.52 10.00 8 178680 133 56113246
Neoplasm progression 15.47 10.00 51 178637 31965 56081414
Sleep talking 15.46 10.00 17 178671 930 56112449
Nephropathy toxic 15.42 10.00 4 178684 8523 56104856
Pancreatic enlargement 15.40 10.00 6 178682 49 56113330
Vasoplegia syndrome 15.39 10.00 20 178668 1305 56112074
Slow speech 15.37 10.00 20 178668 1307 56112072
Ataxia 15.35 10.00 88 178600 14315 56099064
Premature delivery 15.33 10.00 40 178648 27020 56086359
Basal cell carcinoma 15.29 10.00 36 178652 25185 56088194
Cytopenia 15.12 10.00 6 178682 9749 56103630
Blood lactic acid increased 15.11 10.00 48 178640 6016 56107363
Urinary tract infection 15.11 10.00 617 178071 239896 55873483
Kleptomania 15.07 10.00 5 178683 24 56113355
Abnormal sleep-related event 15.06 10.00 15 178673 731 56112648
Labour complication 14.97 10.00 7 178681 93 56113286
Apallic syndrome 14.91 10.00 14 178674 634 56112745
Foetal alcohol syndrome 14.90 10.00 5 178683 25 56113354
Right ventricular systolic pressure decreased 14.90 10.00 5 178683 25 56113354
Purging 14.89 10.00 6 178682 54 56113325
Bladder trabeculation 14.89 10.00 6 178682 54 56113325
Merycism 14.86 10.00 9 178679 207 56113172
Activation syndrome 14.86 10.00 9 178679 207 56113172
Hypokinesia 14.83 10.00 80 178608 12723 56100656
Increased appetite 14.83 10.00 61 178627 8674 56104705
Sternal fracture 14.80 10.00 25 178663 2065 56111314
Language disorder 14.80 10.00 24 178664 1917 56111462
Unresponsive to stimuli 14.79 10.00 160 178528 31565 56081814
Neurotoxicity 14.76 10.00 17 178671 15778 56097601
Ligament pain 14.74 10.00 9 178679 210 56113169
Persecutory delusion 14.69 10.00 28 178660 2542 56110837
Lung diffusion test decreased 14.60 10.00 14 178674 651 56112728
Musculoskeletal pain 14.58 10.00 176 178512 80976 56032403
Infantile apnoea 14.56 10.00 16 178672 875 56112504
Epstein-Barr virus infection 14.49 10.00 3 178685 7460 56105919
Osteoarthritis 14.48 10.00 174 178514 80122 56033257
Urticaria 14.47 10.00 349 178339 144327 55969052
Brief psychotic disorder with marked stressors 14.43 10.00 6 178682 59 56113320
Foetal arrhythmia 14.42 10.00 8 178680 155 56113224
Ideas of reference 14.34 10.00 7 178681 103 56113276
Anal atresia 14.24 10.00 11 178677 380 56112999
Marital problem 14.20 10.00 8 178680 160 56113219
Liver function test increased 14.16 10.00 44 178644 28089 56085290
Flight of ideas 14.14 10.00 11 178677 384 56112995
Exposure via ingestion 14.13 10.00 29 178659 2779 56110600
Accidental exposure to product by child 14.09 10.00 18 178670 1155 56112224
Cerebral haematoma 14.06 10.00 32 178656 3291 56110088
Cogwheel rigidity 14.03 10.00 23 178665 1854 56111525
Postmortem blood drug level increased 14.02 10.00 13 178675 579 56112800
Nonspecific reaction 13.99 10.00 23 178665 1858 56111521
Anuria 13.97 10.00 74 178614 11686 56101693
Perinatal depression 13.89 10.00 13 178675 586 56112793
Arthritis 13.87 10.00 228 178460 99624 56013755
Pulmonary artery stenosis congenital 13.78 10.00 9 178679 237 56113142
Haemangioma 13.77 10.00 27 178661 2503 56110876
Drug abuser 13.77 10.00 29 178659 2830 56110549
Somnolence neonatal 13.76 10.00 7 178681 113 56113266
Foot deformity 13.67 10.00 35 178653 23790 56089589
Pneumonitis 13.45 10.00 53 178635 31511 56081868
Cognitive disorder 13.44 10.00 225 178463 48908 56064471
Immunodeficiency 13.42 10.00 19 178669 16138 56097241
Rhinorrhoea 13.42 10.00 116 178572 56921 56056458
Barotrauma 13.40 10.00 8 178680 179 56113200
Tympanic membrane disorder 13.36 10.00 8 178680 180 56113199
Respiratory rate decreased 13.35 10.00 31 178657 3231 56110148
Proteinuria 13.31 10.00 22 178666 17548 56095831
Hereditary non-polyposis colorectal cancer syndrome 13.28 10.00 7 178681 122 56113257
Divorced 13.28 10.00 4 178684 13 56113366
Radius fracture 13.27 10.00 31 178657 3244 56110135
Jaundice neonatal 13.24 10.00 15 178673 848 56112531
Foetal growth restriction 13.19 10.00 51 178637 7048 56106331
Muscle tone disorder 13.18 10.00 7 178681 124 56113255
Macular degeneration 13.13 10.00 25 178663 18883 56094496
Ventricular hypokinesia 13.09 10.00 36 178652 4165 56109214
Dry mouth 13.08 10.00 281 178407 63924 56049455
Injection site rash 13.07 10.00 21 178667 16937 56096442
Thrombosis 13.05 10.00 123 178565 59304 56054075
Aplastic anaemia 13.03 10.00 6 178682 8922 56104457
Myelodysplastic syndrome 12.94 10.00 20 178668 16386 56096993
Respiratory failure 12.90 10.00 218 178470 94844 56018535
Respiratory acidosis 12.90 10.00 46 178642 6117 56107262
Sleep apnoea syndrome 12.88 10.00 133 178555 25928 56087451
Mechanical urticaria 12.86 10.00 11 178677 440 56112939
Focal dyscognitive seizures 12.85 10.00 28 178660 2797 56110582
Headache 12.82 10.00 1991 176697 557053 55556326
Product formulation issue 12.82 10.00 12 178676 541 56112838
Parkinsonian gait 12.82 10.00 11 178677 442 56112937
Blood calcium decreased 12.82 10.00 36 178652 23733 56089646
Neuropsychiatric syndrome 12.81 10.00 5 178683 41 56113338
Accidental exposure to product 12.80 10.00 38 178650 24609 56088770
Arachnoid cyst 12.80 10.00 8 178680 195 56113184
Sleep disorder 12.79 10.00 293 178395 67370 56046009
Brain contusion 12.75 10.00 12 178676 545 56112834
Colitis 12.74 10.00 79 178609 41732 56071647
Electroencephalogram abnormal 12.73 10.00 32 178656 3507 56109872
Ocular hypertension 12.72 10.00 15 178673 886 56112493
Hypertonia 12.68 10.00 35 178653 4057 56109322
Skin disorder 12.65 10.00 42 178646 26267 56087112
Grip strength decreased 12.65 10.00 20 178668 16236 56097143
Wheezing 12.62 10.00 165 178523 74861 56038518
Blood creatine phosphokinase increased 12.59 10.00 140 178548 27812 56085567
Respiration abnormal 12.58 10.00 43 178645 5598 56107781
Balance disorder 12.55 10.00 325 178363 76195 56037184
Lip and/or oral cavity cancer 12.55 10.00 13 178675 664 56112715
Cellulitis 12.54 10.00 165 178523 74784 56038595
Bladder dilatation 12.54 10.00 14 178674 779 56112600
Multiple allergies 12.54 10.00 9 178679 10487 56102892
Back pain 12.53 10.00 620 178068 236550 55876829
Decreased interest 12.52 10.00 29 178659 3017 56110362
Metastases to bone 12.52 10.00 27 178661 19481 56093898
Tubulointerstitial nephritis 12.50 10.00 21 178667 16644 56096735
Hypnagogic hallucination 12.47 10.00 7 178681 139 56113240
Coarctation of the aorta 12.46 10.00 12 178676 561 56112818
Arrhythmia 12.45 10.00 168 178520 34915 56078464
Second primary malignancy 12.42 10.00 4 178684 7398 56105981
Rash pruritic 12.36 10.00 107 178581 52487 56060892
Formication 12.35 10.00 34 178654 3936 56109443
Respiratory tract congestion 12.30 10.00 19 178669 15572 56097807
Drug level above therapeutic 12.25 10.00 36 178652 4326 56109053
Anaemia of pregnancy 12.25 10.00 6 178682 89 56113290
Obsessive rumination 12.20 10.00 3 178685 3 56113376
Anxiety disorder due to a general medical condition 12.20 10.00 3 178685 3 56113376
Antidepressant drug level decreased 12.20 10.00 3 178685 3 56113376
Ulcer 12.17 10.00 34 178654 22451 56090928
Feeling of body temperature change 12.06 10.00 37 178651 4552 56108827
Bradycardia 12.05 10.00 290 178398 67214 56046165
Therapeutic response unexpected 12.03 10.00 94 178594 16950 56096429
Substance use 12.02 10.00 10 178678 385 56112994
Dialysis 12.02 10.00 8 178680 9694 56103685
No adverse event 12.00 10.00 67 178621 36307 56077072
Drug withdrawal convulsions 12.00 10.00 18 178670 1344 56112035
Regressive behaviour 11.95 10.00 7 178681 151 56113228
Multiple sclerosis 11.95 10.00 138 178550 27664 56085715
Housebound 11.95 10.00 8 178680 220 56113159
Liver disorder 11.94 10.00 87 178601 44283 56069096
Exposure via transplant 11.92 10.00 4 178684 20 56113359
Urinary retention 11.91 10.00 139 178549 27935 56085444
Device related infection 11.90 10.00 33 178655 21847 56091532
Exposure during pregnancy 11.89 10.00 538 178150 135804 55977575
Delusional disorder, unspecified type 11.89 10.00 10 178678 391 56112988
Polydactyly 11.88 10.00 9 178679 302 56113077
Personality change 11.82 10.00 43 178645 5774 56107605
Parachute mitral valve 11.73 10.00 6 178682 98 56113281
Haemophagocytic lymphohistiocytosis 11.71 10.00 8 178680 9564 56103815
Amenorrhoea 11.69 10.00 58 178630 8928 56104451
Feeling hot 11.66 10.00 192 178496 41595 56071784
Photophobia 11.60 10.00 89 178599 15961 56097418
COVID-19 11.57 10.00 168 178520 74890 56038489
Haematocrit decreased 11.53 10.00 69 178619 36760 56076619
Xanthopsia 11.52 10.00 7 178681 162 56113217
Intestinal anastomosis complication 11.51 10.00 8 178680 234 56113145
Hypertonia neonatal 11.45 10.00 8 178680 236 56113143
Breech presentation 11.39 10.00 16 178672 1125 56112254
Pulmonary vein occlusion 11.36 10.00 6 178682 105 56113274
Thrombotic microangiopathy 11.33 10.00 8 178680 9403 56103976
Ocular hyperaemia 11.33 10.00 34 178654 21945 56091434
Morbihan disease 11.32 10.00 4 178684 24 56113355
Cardiac valve disease 11.31 10.00 33 178655 3948 56109431
Ultrasound abdomen abnormal 11.30 10.00 5 178683 58 56113321
Pleural rub 11.30 10.00 5 178683 58 56113321
Cataract 11.28 10.00 106 178582 51141 56062238
Osteonecrosis of jaw 11.25 10.00 61 178627 33297 56080082
Transplant rejection 11.25 10.00 9 178679 9925 56103454
Pre-eclampsia 11.20 10.00 55 178633 8431 56104948
Anxiety disorder 11.18 10.00 32 178656 3788 56109591
Blood urea increased 11.14 10.00 40 178648 24433 56088946
Hepatocellular injury 11.13 10.00 131 178557 26383 56086996
Left ventricular hypertrophy 11.12 10.00 38 178650 4946 56108433
Parasomnia 11.08 10.00 10 178678 430 56112949
Gun shot wound 11.07 10.00 6 178682 111 56113268
Head injury 11.04 10.00 125 178563 24941 56088438
Congenital pharyngeal anomaly 10.99 10.00 3 178685 6 56113373
Bronchiectasis 10.99 10.00 68 178620 11366 56102013
Skin texture abnormal 10.97 10.00 10 178678 436 56112943
Dissociative amnesia 10.92 10.00 4 178684 27 56113352
Platelet aggregation decreased 10.92 10.00 4 178684 27 56113352
Congenital naevus 10.90 10.00 7 178681 179 56113200
Enthesopathy 10.89 10.00 6 178682 8057 56105322
Urosepsis 10.84 10.00 23 178665 16693 56096686
Obsessive-compulsive disorder 10.80 10.00 31 178657 3675 56109704
Pleural disorder 10.79 10.00 11 178677 551 56112828
Muscle tightness 10.77 10.00 65 178623 10771 56102608
Rhythm idioventricular 10.76 10.00 7 178681 183 56113196
Agoraphobia 10.76 10.00 9 178679 349 56113030
Peritonitis 10.75 10.00 22 178666 16180 56097199
Hallucination, tactile 10.73 10.00 8 178680 262 56113117
Staring 10.72 10.00 18 178670 1480 56111899
Heart rate increased 10.71 10.00 343 178345 82930 56030449
Blood bilirubin increased 10.70 10.00 62 178626 33292 56080087
Haemolytic anaemia 10.69 10.00 9 178679 9676 56103703
Dreamy state 10.68 10.00 4 178684 29 56113350
Hyperemesis gravidarum 10.65 10.00 11 178677 560 56112819
Sleep paralysis 10.65 10.00 11 178677 560 56112819
Hypoglycaemia 10.64 10.00 242 178446 55573 56057806
Cartilage injury 10.63 10.00 20 178668 1798 56111581
Injection site bruising 10.62 10.00 75 178613 38446 56074933
Prescription form tampering 10.62 10.00 11 178677 562 56112817
Communication disorder 10.61 10.00 23 178665 2290 56111089
Pathogen resistance 10.50 10.00 3 178685 5997 56107382
Hepatotoxicity 10.49 10.00 57 178631 31096 56082283
Hypoglycaemic seizure 10.46 10.00 10 178678 463 56112916
Impatience 10.46 10.00 9 178679 363 56113016
Distributive shock 10.45 10.00 15 178673 1076 56112303
Skin discolouration 10.43 10.00 65 178623 34291 56079088
Therapeutic response decreased 10.42 10.00 112 178576 52646 56060733
Toxicologic test abnormal 10.41 10.00 12 178676 692 56112687
Hypersexuality 10.39 10.00 10 178678 467 56112912
Foetal heart rate deceleration abnormality 10.39 10.00 10 178678 467 56112912
Polycythaemia 10.37 10.00 13 178675 818 56112561
Throat irritation 10.36 10.00 61 178627 32622 56080757
Tongue discomfort 10.36 10.00 21 178667 1995 56111384
Hypoalbuminaemia 10.35 10.00 11 178677 10588 56102791
Pulmonary pain 10.32 10.00 26 178662 2854 56110525
Hypervolaemia 10.30 10.00 46 178642 26412 56086967
Coordination abnormal 10.27 10.00 72 178616 12549 56100830
Long QT syndrome 10.23 10.00 27 178661 3049 56110330
Glassy eyes 10.21 10.00 5 178683 74 56113305
Intellectual disability 10.21 10.00 13 178675 831 56112548
Foaming at mouth 10.19 10.00 15 178673 1101 56112278
Attention-seeking behaviour 10.15 10.00 5 178683 75 56113304
Impulse-control disorder 10.15 10.00 12 178676 711 56112668
Maternal exposure during breast feeding 10.14 10.00 30 178658 3617 56109762
Subacute kidney injury 10.14 10.00 3 178685 9 56113370
Crush injury 10.14 10.00 3 178685 9 56113370
Pain in jaw 10.07 10.00 80 178608 39956 56073423
Pseudophaeochromocytoma 10.04 10.00 5 178683 77 56113302
Tanning 10.04 10.00 5 178683 77 56113302

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 780.40 11.04 1009 72523 90505 31533307
Serotonin syndrome 750.68 11.04 494 73038 18279 31605533
Drug withdrawal syndrome 453.50 11.04 364 73168 18386 31605426
Suicide attempt 453.06 11.04 493 73039 36755 31587057
Suicidal ideation 441.30 11.04 481 73051 35925 31587887
Intentional overdose 435.49 11.04 508 73024 40881 31582931
Toxicity to various agents 420.13 11.04 1140 72392 180347 31443465
Depression 294.32 11.04 650 72882 90165 31533647
Overdose 286.89 11.04 617 72915 84047 31539765
Withdrawal syndrome 226.54 11.04 200 73332 11517 31612295
Anxiety 207.03 11.04 569 72963 90464 31533348
Foetal exposure during pregnancy 179.24 11.04 332 73200 40544 31583268
Hyperhidrosis 174.26 11.04 442 73090 66951 31556861
Drug abuse 171.90 11.04 520 73012 87238 31536574
Coma 164.09 11.04 321 73211 40829 31582983
Respiratory disorder neonatal 155.98 11.04 74 73458 1421 31622391
Agitation 153.47 11.04 368 73164 53801 31570011
Maternal exposure during pregnancy 151.53 11.04 108 73424 4548 31619264
Mania 148.85 11.04 142 73390 9035 31614777
Drug withdrawal syndrome neonatal 147.03 11.04 95 73437 3397 31620415
Febrile neutropenia 142.99 11.04 52 73480 121797 31502015
Sopor 142.19 11.04 154 73378 11398 31612414
Disturbance in attention 137.86 11.04 212 73320 22238 31601574
Pneumonia 137.09 11.04 366 73166 334946 31288866
Drug interaction 131.35 11.04 880 72652 207663 31416149
Poisoning deliberate 129.41 11.04 119 73413 7225 31616587
Mydriasis 126.95 11.04 112 73420 6440 31617372
Exposure during pregnancy 122.60 11.04 124 73408 8474 31615338
Pyrexia 122.35 11.04 334 73198 303506 31320306
Nightmare 117.63 11.04 143 73389 11994 31611818
Major depression 116.67 11.04 89 73443 4164 31619648
Intentional self-injury 113.31 11.04 147 73385 13168 31610644
Anaemia 111.84 11.04 203 73329 213319 31410493
Tremor 107.23 11.04 405 73127 76015 31547797
Selective eating disorder 106.64 11.04 60 73472 1660 31622152
Myoclonus 104.59 11.04 145 73387 13845 31609967
Cataplexy 104.22 11.04 37 73495 322 31623490
Restlessness 103.93 11.04 191 73341 23170 31600642
Sedation 103.90 11.04 170 73362 18795 31605017
Hypotonia neonatal 101.61 11.04 53 73479 1256 31622556
Small for dates baby 101.39 11.04 77 73455 3578 31620234
Depressed mood 100.99 11.04 161 73371 17414 31606398
Somnolence 98.43 11.04 474 73058 98971 31524841
Bipolar disorder 93.60 11.04 74 73458 3650 31620162
Sepsis 91.14 11.04 132 73400 151797 31472015
Neonatal respiratory distress syndrome 90.85 11.04 74 73458 3811 31620001
Electrocardiogram QT prolonged 90.75 11.04 242 73290 37745 31586067
Hyperreflexia 90.47 11.04 66 73466 2883 31620929
Irritability 89.31 11.04 177 73355 22712 31601100
Drug dependence 88.58 11.04 175 73357 22404 31601408
Neutropenia 84.13 11.04 122 73410 140242 31483570
Seizure 79.65 11.04 448 73084 99320 31524492
Poisoning 79.63 11.04 109 73423 10282 31613530
Dyspnoea 76.28 11.04 476 73056 343003 31280809
Rash 76.13 11.04 228 73304 201258 31422554
Erectile dysfunction 75.35 11.04 149 73383 19086 31604726
Psychotic symptom 74.26 11.04 46 73486 1526 31622286
Diarrhoea 73.38 11.04 498 73034 351911 31271901
Dyskinesia 72.49 11.04 154 73378 20756 31603056
Disease progression 72.41 11.04 62 73470 90402 31533410
Aggression 71.04 11.04 219 73313 37072 31586740
Acute kidney injury 69.33 11.04 374 73158 279340 31344472
Off label use 69.21 11.04 497 73035 346777 31277035
Atrial septal defect 67.74 11.04 82 73450 6845 31616967
Agitation neonatal 67.74 11.04 38 73494 1045 31622767
Bradycardia neonatal 66.77 11.04 36 73496 914 31622898
Talipes 62.80 11.04 44 73488 1802 31622010
Malignant neoplasm progression 62.18 11.04 55 73477 78943 31544869
Rheumatoid arthritis 62.09 11.04 17 73515 47792 31576020
Hypertonia 59.83 11.04 59 73473 3909 31619903
Anger 59.76 11.04 99 73433 11054 31612758
Delusion 59.65 11.04 103 73429 11894 31611918
Antipsychotic drug level above therapeutic 59.58 11.04 36 73496 1141 31622671
Platelet count decreased 59.50 11.04 103 73429 110332 31513480
Insomnia 57.57 11.04 397 73135 94439 31529373
Homicide 56.40 11.04 32 73500 900 31622912
Infantile apnoea 56.33 11.04 32 73500 902 31622910
Hypertonia neonatal 56.04 11.04 25 73507 414 31623398
Somnambulism 55.74 11.04 49 73483 2803 31621009
Hallucination, auditory 55.56 11.04 92 73440 10268 31613544
Postmortem blood drug level increased 55.46 11.04 21 73511 223 31623589
Psychotic disorder 54.22 11.04 143 73389 22150 31601662
Intentional product misuse 53.89 11.04 202 73330 37749 31586063
Altered state of consciousness 53.21 11.04 137 73395 20914 31602898
Interstitial lung disease 53.00 11.04 39 73493 61364 31562448
Miosis 52.69 11.04 81 73451 8489 31615323
Parkinsonism 52.42 11.04 76 73456 7560 31616252
Hallucination, visual 52.08 11.04 114 73418 15680 31608132
Plasma cell myeloma 51.31 11.04 34 73498 56497 31567315
Cough 51.25 11.04 152 73380 134662 31489150
Sexual dysfunction 50.94 11.04 66 73466 5902 31617910
Thrombocytopenia 50.70 11.04 166 73366 142581 31481231
Death 50.68 11.04 564 72968 360005 31263807
Stress cardiomyopathy 50.29 11.04 38 73494 1752 31622060
Renal impairment 49.80 11.04 77 73455 86272 31537540
Feelings of worthlessness 49.34 11.04 20 73512 258 31623554
Infection 49.25 11.04 71 73461 81860 31541952
Congenital megaureter 49.13 11.04 17 73515 136 31623676
Confusional state 48.73 11.04 498 73034 132836 31490976
Septic shock 48.61 11.04 49 73483 66109 31557703
Pruritus 48.39 11.04 140 73392 125027 31498785
Haemoglobin decreased 48.10 11.04 120 73412 112555 31511257
Neonatal tachypnoea 47.09 11.04 17 73515 156 31623656
Neuropathy peripheral 47.02 11.04 64 73468 75585 31548227
Drug screen positive 46.78 11.04 51 73481 3801 31620011
Akathisia 46.64 11.04 70 73462 7183 31616629
Respiratory failure 46.53 11.04 104 73428 101345 31522467
Panic attack 46.29 11.04 77 73455 8626 31615186
Cytomegalovirus infection 45.49 11.04 3 73529 24704 31599108
Maternal drugs affecting foetus 44.51 11.04 50 73482 3853 31619959
Impulsive behaviour 44.26 11.04 37 73495 1976 31621836
Feeling jittery 44.12 11.04 49 73483 3728 31620084
Cardiac failure congestive 43.70 11.04 73 73459 79314 31544498
Hypomania 42.88 11.04 38 73494 2197 31621615
Feeling abnormal 42.84 11.04 252 73280 56750 31567062
Clonus 42.79 11.04 40 73492 2479 31621333
Erythema 42.37 11.04 76 73456 80329 31543483
Cyanosis neonatal 41.78 11.04 18 73514 273 31623539
Neuroleptic malignant syndrome 40.80 11.04 108 73424 16761 31607051
Psychomotor hyperactivity 40.53 11.04 73 73459 8714 31615098
Tachycardia 40.45 11.04 309 73223 75898 31547914
Gastrointestinal haemorrhage 40.03 11.04 82 73450 82467 31541345
Antidepressant drug level increased 39.93 11.04 14 73518 117 31623695
Pancytopenia 39.63 11.04 90 73442 87226 31536586
Restless legs syndrome 39.10 11.04 67 73465 7689 31616123
Sleep disorder 38.87 11.04 142 73390 26206 31597606
Urinary retention 38.68 11.04 168 73364 33557 31590255
Memory impairment 38.56 11.04 183 73349 37947 31585865
Abnormal behaviour 38.22 11.04 132 73400 23696 31600116
Bone marrow failure 38.20 11.04 9 73523 27999 31595813
Stomatitis 38.17 11.04 22 73510 39416 31584396
Atrial fibrillation 37.88 11.04 136 73396 113647 31510165
Blood creatinine increased 37.13 11.04 96 73436 88982 31534830
Electrocardiogram QRS complex prolonged 36.46 11.04 47 73485 4182 31619630
Social anxiety disorder 35.97 11.04 16 73516 263 31623549
Oedema peripheral 34.79 11.04 134 73398 109705 31514107
Self-injurious ideation 34.54 11.04 29 73503 1558 31622254
Tremor neonatal 33.65 11.04 17 73515 376 31623436
Tardive dyskinesia 33.41 11.04 52 73480 5507 31618305
Product substitution issue 33.30 11.04 70 73462 9362 31614450
Muscle rigidity 33.27 11.04 72 73460 9825 31613987
Neonatal toxicity 33.20 11.04 9 73523 27 31623785
Poor weight gain neonatal 32.49 11.04 8 73524 14 31623798
Macrophages increased 32.47 11.04 13 73519 162 31623650
Persecutory delusion 31.85 11.04 33 73499 2319 31621493
Neonatal disorder 31.67 11.04 21 73511 785 31623027
Electric shock 31.64 11.04 12 73520 128 31623684
Cardio-respiratory arrest 31.62 11.04 217 73315 51509 31572303
Infusion related reaction 31.55 11.04 39 73493 48016 31575796
Pleural effusion 31.02 11.04 81 73451 74839 31548973
Suicidal behaviour 30.82 11.04 26 73506 1406 31622406
Obsessive-compulsive disorder 30.82 11.04 47 73485 4890 31618922
Poor quality sleep 30.69 11.04 60 73472 7618 31616194
Hyperthermia 30.50 11.04 70 73462 9934 31613878
Encephalopathy neonatal 30.46 11.04 9 73523 40 31623772
Logorrhoea 30.44 11.04 32 73500 2287 31621525
Apgar score low 30.34 11.04 21 73511 843 31622969
Paranoia 30.16 11.04 72 73460 10483 31613329
Ejaculation disorder 30.01 11.04 22 73510 968 31622844
Arthralgia 29.88 11.04 217 73315 151207 31472605
International normalised ratio increased 29.38 11.04 37 73495 45186 31578626
Thinking abnormal 29.23 11.04 49 73483 5524 31618288
Homicidal ideation 29.21 11.04 33 73499 2558 31621254
Chronic kidney disease 29.19 11.04 27 73505 37948 31585864
Normal pressure hydrocephalus 29.18 11.04 12 73520 161 31623651
Hypospadias 29.03 11.04 36 73496 3080 31620732
Muscle twitching 28.96 11.04 61 73471 8169 31615643
Sleep apnoea syndrome 28.85 11.04 102 73430 18523 31605289
Libido decreased 28.79 11.04 43 73489 4393 31619419
Prostate cancer 28.59 11.04 27 73505 37574 31586238
Dysphoria 28.57 11.04 30 73502 2142 31621670
Cognitive disorder 28.46 11.04 124 73408 24799 31599013
Mood altered 28.38 11.04 61 73471 8285 31615527
Extrapyramidal disorder 28.07 11.04 75 73457 11703 31612109
White blood cell count decreased 28.07 11.04 106 73426 87292 31536520
Micturition urgency 28.04 11.04 49 73483 5711 31618101
Implant site extravasation 27.96 11.04 15 73517 377 31623435
Abnormal dreams 27.75 11.04 55 73477 7053 31616759
Apathy 27.56 11.04 52 73480 6430 31617382
Thermophobia 27.55 11.04 9 73523 59 31623753
Generalised tonic-clonic seizure 27.38 11.04 105 73427 19826 31603986
Multiple organ dysfunction syndrome 27.28 11.04 75 73457 68128 31555684
Disseminated intravascular coagulation 27.23 11.04 7 73525 20530 31603282
Mental impairment 27.21 11.04 65 73467 9467 31614345
Wrong dose 27.09 11.04 16 73516 486 31623326
Liver disorder 26.77 11.04 18 73514 29689 31594123
Decreased interest 26.65 11.04 29 73503 2156 31621656
Dissociation 26.56 11.04 23 73509 1289 31622523
Alcoholism 26.56 11.04 36 73496 3363 31620449
Hepatic function abnormal 26.49 11.04 34 73498 41188 31582624
Disorientation 26.46 11.04 141 73391 30603 31593209
Acoustic stimulation tests abnormal 26.34 11.04 9 73523 69 31623743
Epilepsy 25.82 11.04 107 73425 20934 31602878
Substance abuser 25.54 11.04 10 73522 117 31623695
Premature baby 25.50 11.04 96 73436 17970 31605842
Euphoric mood 25.46 11.04 43 73489 4877 31618935
Loss of consciousness 25.44 11.04 283 73249 77072 31546740
Neonatal testicular torsion 25.34 11.04 5 73527 0 31623812
COVID-19 25.28 11.04 56 73476 54765 31569047
Eosinophilic myocarditis 25.21 11.04 15 73517 462 31623350
Potentiating drug interaction 25.18 11.04 41 73491 4512 31619300
Stevens-Johnson syndrome 24.87 11.04 5 73527 17367 31606445
Muscle mass 24.76 11.04 12 73520 242 31623570
Mucosal inflammation 24.71 11.04 26 73506 34401 31589411
Pneumocystis jirovecii pneumonia 24.62 11.04 6 73526 18245 31605567
Cerebral infarction 24.42 11.04 15 73517 25962 31597850
Weight increased 24.41 11.04 297 73235 82650 31541162
Pyramidal tract syndrome 24.40 11.04 11 73521 187 31623625
Joint swelling 24.29 11.04 55 73477 53376 31570436
Tearfulness 24.25 11.04 26 73506 1901 31621911
Multiple drug therapy 24.07 11.04 14 73518 413 31623399
Alopecia 23.95 11.04 9 73523 20686 31603126
Arachnoid cyst 23.93 11.04 11 73521 196 31623616
Reduced facial expression 23.89 11.04 18 73514 826 31622986
Foetal malnutrition 23.80 11.04 8 73524 58 31623754
Neonatal respiratory failure 23.66 11.04 13 73519 343 31623469
Cardiac failure 23.43 11.04 111 73421 85842 31537970
Amnesia 23.42 11.04 112 73420 23290 31600522
Priapism 23.40 11.04 40 73492 4580 31619232
Testicular atrophy 23.39 11.04 15 73517 529 31623283
Renal failure 23.24 11.04 179 73353 123151 31500661
Pressure of speech 22.83 11.04 14 73518 456 31623356
Anaphylactic reaction 22.73 11.04 21 73511 29532 31594280
Inappropriate antidiuretic hormone secretion 22.73 11.04 68 73464 11319 31612493
Head circumference abnormal 22.70 11.04 7 73525 37 31623775
Mood swings 22.69 11.04 52 73480 7372 31616440
Paraesthesia 22.67 11.04 214 73318 55857 31567955
Acute myocardial infarction 22.55 11.04 53 73479 50770 31573042
Pulmonary contusion 22.54 11.04 7 73525 38 31623774
Depersonalisation/derealisation disorder 22.38 11.04 15 73517 571 31623241
Product residue present 22.31 11.04 29 73503 2601 31621211
Dry mouth 22.30 11.04 114 73418 24344 31599468
Phaeochromocytoma malignant 22.30 11.04 8 73524 72 31623740
Blood ethanol increased 22.26 11.04 14 73518 477 31623335
Depression suicidal 22.19 11.04 23 73509 1617 31622195
Renal aplasia 22.19 11.04 16 73516 686 31623126
Pneumonitis 22.16 11.04 23 73509 30629 31593183
Salivary hypersecretion 22.10 11.04 53 73479 7739 31616073
Kidney duplex 22.01 11.04 13 73519 395 31623417
External auditory canal atresia 21.97 11.04 10 73522 174 31623638
Fall 21.95 11.04 576 72956 185513 31438299
Iris coloboma 21.89 11.04 6 73526 19 31623793
Splenomegaly 21.81 11.04 3 73529 13746 31610066
Toxic cardiomyopathy 21.70 11.04 11 73521 245 31623567
Retinal coloboma 21.66 11.04 6 73526 20 31623792
Blood bilirubin increased 21.54 11.04 30 73502 35106 31588706
Neonatal behavioural syndrome 21.47 11.04 9 73523 127 31623685
Hangover 21.44 11.04 18 73514 967 31622845
Myelodysplastic syndrome 21.25 11.04 9 73523 19242 31604570
Coma scale abnormal 21.23 11.04 34 73498 3689 31620123
Myocardial fibrosis 21.17 11.04 19 73513 1117 31622695
Abulia 21.09 11.04 14 73518 524 31623288
Neonatal respiratory distress 21.07 11.04 14 73518 525 31623287
Hypervigilance 20.98 11.04 9 73523 135 31623677
Coagulation disorder neonatal 20.81 11.04 6 73526 24 31623788
Histamine level increased 20.68 11.04 7 73525 52 31623760
Electrocardiogram QT shortened 20.45 11.04 9 73523 144 31623668
Bipolar II disorder 20.43 11.04 6 73526 26 31623786
Loose associations 20.34 11.04 7 73525 55 31623757
Tachycardia foetal 20.33 11.04 12 73520 364 31623448
Microcephaly 20.33 11.04 16 73516 784 31623028
Antidepressant discontinuation syndrome 20.27 11.04 4 73528 0 31623812
External ear disorder 20.25 11.04 6 73526 27 31623785
Foetal hypokinesia 20.10 11.04 12 73520 372 31623440
Drug hypersensitivity 20.09 11.04 257 73275 72342 31551470
Hepatocellular injury 20.05 11.04 101 73431 21443 31602369
Gun shot wound 19.80 11.04 18 73514 1076 31622736
Affective disorder 19.79 11.04 33 73499 3703 31620109
Persistent depressive disorder 19.69 11.04 11 73521 300 31623512
Metabolic syndrome 19.51 11.04 21 73511 1542 31622270
Poor sucking reflex 19.43 11.04 11 73521 308 31623504
Bronchopulmonary aspergillosis 19.36 11.04 4 73528 13630 31610182
Foaming at mouth 19.27 11.04 15 73517 723 31623089
Blood cholesterol increased 19.25 11.04 84 73448 16809 31607003
Personality disorder 19.21 11.04 18 73514 1119 31622693
Violence-related symptom 19.07 11.04 13 73519 509 31623303
Tumour lysis syndrome 19.00 11.04 6 73526 15379 31608433
Penoscrotal fusion 18.97 11.04 5 73527 13 31623799
Condition aggravated 18.85 11.04 506 73026 163503 31460309
Rhabdomyolysis 18.84 11.04 228 73304 63353 31560459
Bruxism 18.79 11.04 21 73511 1609 31622203
Synovitis 18.75 11.04 3 73529 12280 31611532
Haematoma 18.74 11.04 17 73515 24122 31599690
Lymphadenopathy 18.44 11.04 20 73512 26101 31597711
Visual evoked potentials abnormal 18.43 11.04 7 73525 75 31623737
Urticaria 18.30 11.04 70 73462 57447 31566365
Loss of libido 18.16 11.04 25 73507 2370 31621442
Physical deconditioning 18.11 11.04 16 73516 921 31622891
Nephrolithiasis 18.09 11.04 117 73415 27222 31596590
Bradykinesia 18.06 11.04 31 73501 3561 31620251
Hydrops foetalis 18.06 11.04 12 73520 450 31623362
Dyskinesia neonatal 18.04 11.04 4 73528 3 31623809
Patent ductus arteriosus 17.99 11.04 29 73503 3164 31620648
Gastrointestinal hypermotility 17.90 11.04 8 73524 133 31623679
Hypokalaemia 17.83 11.04 64 73468 53510 31570302
Neutrophil count decreased 17.82 11.04 52 73480 46342 31577470
Rash maculo-papular 17.81 11.04 20 73512 25699 31598113
Thrombosis 17.79 11.04 50 73482 45101 31578711
Contraindicated product administered 17.79 11.04 12 73520 19760 31604052
Drug screen false positive 17.73 11.04 14 73518 689 31623123
Haematuria 17.73 11.04 52 73480 46262 31577550
Forearm fracture 17.72 11.04 7 73525 84 31623728
Hypoxia 17.49 11.04 59 73473 50254 31573558
Emotional disorder 17.43 11.04 38 73494 5211 31618601
Sleep-related eating disorder 17.26 11.04 10 73522 293 31623519
Acute myeloid leukaemia 17.25 11.04 11 73521 18661 31605151
Hyperkalaemia 17.01 11.04 84 73448 64267 31559545
Tubulointerstitial nephritis 16.94 11.04 11 73521 18485 31605327
Cerebellar syndrome 16.89 11.04 23 73509 2158 31621654
Oedema 16.87 11.04 47 73485 42514 31581298
Enuresis 16.86 11.04 23 73509 2161 31621651
Congenital central nervous system anomaly 16.51 11.04 12 73520 521 31623291
Decreased appetite 16.50 11.04 253 73279 152964 31470848
Cerebral ventricle dilatation 16.50 11.04 15 73517 897 31622915
Social avoidant behaviour 16.48 11.04 27 73505 2986 31620826
Pulmonary artery stenosis 16.46 11.04 9 73523 235 31623577
Male orgasmic disorder 16.44 11.04 7 73525 103 31623709
Myelosuppression 16.43 11.04 7 73525 14913 31608899
Heat stroke 16.40 11.04 15 73517 904 31622908
Tinnitus 16.36 11.04 78 73454 16197 31607615
Suspected suicide 16.30 11.04 32 73500 4075 31619737
Blunted affect 16.30 11.04 10 73522 326 31623486
C-reactive protein increased 16.27 11.04 58 73474 48592 31575220
Micturition disorder 16.26 11.04 22 73510 2051 31621761
Action tremor 16.25 11.04 6 73526 59 31623753
Delirium 16.20 11.04 157 73375 41264 31582548
Catatonia 16.15 11.04 35 73497 4779 31619033
Cor pulmonale acute 16.06 11.04 9 73523 247 31623565
Peripheral swelling 16.04 11.04 92 73440 67773 31556039
Floppy infant 16.02 11.04 7 73525 110 31623702
Otospondylomegaepiphyseal dysplasia 16.02 11.04 7 73525 110 31623702
Diarrhoea neonatal 15.97 11.04 5 73527 28 31623784
Hyponatraemic coma 15.97 11.04 5 73527 28 31623784
Respiratory arrest 15.94 11.04 110 73422 26147 31597665
Mental disorder 15.92 11.04 69 73463 13765 31610047
Sleep paralysis 15.92 11.04 8 73524 175 31623637
Palmar-plantar erythrodysaesthesia syndrome 15.91 11.04 8 73524 15475 31608337
Physical assault 15.90 11.04 16 73516 1086 31622726
Food aversion 15.90 11.04 10 73522 341 31623471
Crying 15.80 11.04 38 73494 5559 31618253
Product used for unknown indication 15.75 11.04 14 73518 813 31622999
Ascites 15.73 11.04 46 73486 40967 31582845
Gambling disorder 15.72 11.04 19 73513 1583 31622229
Balance disorder 15.71 11.04 144 73388 37278 31586534
Tricuspid valve sclerosis 15.68 11.04 5 73527 30 31623782
Hospitalisation 15.60 11.04 61 73471 49746 31574066
Cerebral microangiopathy 15.59 11.04 8 73524 183 31623629
Coagulation factor VII level decreased 15.58 11.04 7 73525 118 31623694
CADASIL 15.58 11.04 6 73526 67 31623745
Food craving 15.54 11.04 10 73522 355 31623457
Derealisation 15.51 11.04 12 73520 573 31623239
Pseudohyponatraemia 15.50 11.04 6 73526 68 31623744
Infantile vomiting 15.41 11.04 5 73527 32 31623780
Unemployment 15.41 11.04 5 73527 32 31623780
Influenza 15.39 11.04 52 73480 44273 31579539
Magnetic resonance imaging spinal abnormal 15.26 11.04 6 73526 71 31623741
Selective mutism 15.26 11.04 6 73526 71 31623741
Nervousness 15.26 11.04 61 73471 11739 31612073
Kleptomania 15.21 11.04 3 73529 0 31623812
Onychomycosis 15.20 11.04 22 73510 2184 31621628
Meningocele 15.15 11.04 5 73527 34 31623778
Accidental death 15.12 11.04 22 73510 2195 31621617
Catecholamines urine increased 15.01 11.04 4 73528 11 31623801
Dizziness 14.96 11.04 584 72948 198563 31425249
Laboratory test abnormal 14.91 11.04 13 73519 18801 31605011
Neoplasm progression 14.89 11.04 15 73517 20257 31603555
Toxic epidermal necrolysis 14.86 11.04 14 73518 19510 31604302
Norepinephrine increased 14.76 11.04 4 73528 12 31623800
Urinary straining 14.76 11.04 4 73528 12 31623800
Pneumonia bacterial 14.66 11.04 3 73529 10293 31613519
Food interaction 14.64 11.04 14 73518 893 31622919
Urinary incontinence 14.60 11.04 79 73453 17241 31606571
Tachyphrenia 14.58 11.04 16 73516 1201 31622611
Panic disorder 14.53 11.04 16 73516 1206 31622606
Depressive symptom 14.45 11.04 21 73511 2093 31621719
Upper respiratory tract infection 14.44 11.04 29 73503 29393 31594419
Rebound effect 14.40 11.04 23 73509 2490 31621322
Drug reaction with eosinophilia and systemic symptoms 14.38 11.04 30 73502 29988 31593824
Congestive cardiomyopathy 14.22 11.04 42 73490 6940 31616872
Peritonitis 14.20 11.04 9 73523 15318 31608494
Ex-drug abuser 14.18 11.04 7 73525 147 31623665
Blepharospasm 14.11 11.04 15 73517 1086 31622726
Laryngomalacia 14.07 11.04 9 73523 316 31623496
Impulse-control disorder 13.96 11.04 16 73516 1260 31622552
Prescribed overdose 13.94 11.04 50 73482 9142 31614670
Skull fractured base 13.93 11.04 7 73525 153 31623659
Ventricular septal defect 13.81 11.04 28 73504 3649 31620163
Rhinorrhoea 13.76 11.04 20 73512 22992 31600820
Affect lability 13.76 11.04 27 73505 3438 31620374
Anal stenosis 13.73 11.04 7 73525 158 31623654
Radiation inflammation 13.66 11.04 11 73521 557 31623255
Product dose omission issue 13.64 11.04 168 73364 105418 31518394
Bradyphrenia 13.63 11.04 31 73501 4373 31619439
Limited symptom panic attack 13.56 11.04 5 73527 49 31623763
Psoriasis 13.52 11.04 59 73473 46660 31577152
Cerebral disorder 13.50 11.04 22 73510 2423 31621389
Head discomfort 13.49 11.04 28 73504 3711 31620101
Abdominal distension 13.48 11.04 66 73466 50618 31573194
Diastolic hypotension 13.47 11.04 5 73527 50 31623762
Sexually inappropriate behaviour 13.46 11.04 10 73522 449 31623363
Congenital skin dimples 13.41 11.04 7 73525 166 31623646
Withdrawal catatonia 13.41 11.04 6 73526 100 31623712
Opisthotonus 13.41 11.04 10 73522 452 31623360
Central nervous system inflammation 13.36 11.04 6 73526 101 31623711
Congenital hydronephrosis 13.35 11.04 12 73520 707 31623105
Leukopenia 13.34 11.04 79 73453 57749 31566063
Muscle necrosis 13.32 11.04 13 73519 850 31622962
Chest discomfort 13.30 11.04 64 73468 49305 31574507
Blood glucose increased 13.28 11.04 85 73447 60998 31562814
Lip pruritus 13.13 11.04 3 73529 3 31623809
Nonspecific reaction 13.12 11.04 15 73517 1178 31622634
Inhibitory drug interaction 13.08 11.04 17 73515 1525 31622287
Blood urea increased 13.07 11.04 30 73502 28982 31594830
Muscle tightness 13.05 11.04 31 73501 4498 31619314
Urine output decreased 13.03 11.04 3 73529 9483 31614329
Tunnel vision 12.88 11.04 10 73522 480 31623332
Heart rate increased 12.87 11.04 149 73383 40961 31582851
Fungal infection 12.86 11.04 9 73523 14542 31609270
Sleep terror 12.82 11.04 12 73520 745 31623067
Vertebral foraminal stenosis 12.77 11.04 10 73522 486 31623326
Therapeutic response unexpected 12.77 11.04 48 73484 8976 31614836
Renal disorder 12.76 11.04 22 73510 23623 31600189
Hypotonia 12.75 11.04 41 73491 7092 31616720
Insulin resistance 12.73 11.04 11 73521 615 31623197
Conjunctivitis viral 12.66 11.04 5 73527 60 31623752
Blood creatine phosphokinase increased 12.64 11.04 151 73381 41823 31581989
Pre-existing condition improved 12.60 11.04 21 73511 2356 31621456
Dissociative identity disorder 12.55 11.04 4 73528 24 31623788
Sclerodactylia 12.55 11.04 4 73528 24 31623788
Double inlet left ventricle 12.55 11.04 4 73528 24 31623788
Dysgraphia 12.54 11.04 20 73512 2163 31621649
Antineutrophil cytoplasmic antibody positive 12.53 11.04 11 73521 628 31623184
Dyspnoea exertional 12.52 11.04 47 73485 38790 31585022
Deep vein thrombosis 12.46 11.04 86 73446 60650 31563162
Hypersomnia 12.45 11.04 55 73477 11064 31612748
Cerebrovascular accident 12.44 11.04 121 73411 79363 31544449
Convulsive threshold lowered 12.44 11.04 10 73522 505 31623307
Haemorrhage 12.38 11.04 62 73470 47272 31576540
Onychophagia 12.37 11.04 5 73527 64 31623748
Obstructive airways disorder 12.34 11.04 7 73525 12657 31611155
Distributive shock 12.33 11.04 14 73518 1091 31622721
Fatigue 12.32 11.04 644 72888 334562 31289250
Hepatic failure 12.31 11.04 37 73495 32665 31591147
Sensory disturbance 12.12 11.04 35 73497 5712 31618100
Gastric infection 12.10 11.04 14 73518 1114 31622698
Cerebellar haematoma 12.08 11.04 7 73525 205 31623607
Dehydration 12.04 11.04 199 73333 118912 31504900
Exposure via breast milk 12.03 11.04 18 73514 1842 31621970
Tryptase increased 12.02 11.04 7 73525 207 31623605
Chills 11.98 11.04 112 73420 74038 31549774
Candida infection 11.98 11.04 12 73520 16246 31607566
Wheezing 11.97 11.04 43 73489 35943 31587869
Necrotising ulcerative gingivostomatitis 11.97 11.04 5 73527 70 31623742
Dysphemia 11.94 11.04 16 73516 1478 31622334
Magical thinking 11.92 11.04 3 73529 6 31623806
Congenital ureterocele 11.92 11.04 3 73529 6 31623806
Central nervous system stimulation 11.92 11.04 3 73529 6 31623806
Hypersensitivity 11.90 11.04 78 73454 55665 31568147
Rectal fissure 11.90 11.04 8 73524 306 31623506
Sinus tachycardia 11.85 11.04 70 73462 15779 31608033
Hypogonadism 11.84 11.04 18 73514 1867 31621945
Gonadotrophin deficiency 11.78 11.04 4 73528 30 31623782
Obsessive-compulsive symptom 11.78 11.04 6 73526 135 31623677
Accommodation disorder 11.78 11.04 7 73525 215 31623597
Haemolytic anaemia 11.78 11.04 4 73528 9792 31614020
Substance abuse 11.78 11.04 40 73492 7118 31616694
Alcohol poisoning 11.74 11.04 24 73508 3147 31620665
Spondylolisthesis 11.64 11.04 11 73521 691 31623121
Antidepressant drug level above therapeutic 11.64 11.04 7 73525 220 31623592
Accident at work 11.63 11.04 11 73521 692 31623120
Implant site infection 11.62 11.04 13 73519 997 31622815
Hepatocellular carcinoma 11.58 11.04 3 73529 8753 31615059
Swelling 11.54 11.04 46 73486 37312 31586500
Feeling drunk 11.40 11.04 17 73515 1734 31622078
Flashback 11.36 11.04 6 73526 146 31623666
Diffuse large B-cell lymphoma 11.35 11.04 3 73529 8638 31615174
Skin exfoliation 11.32 11.04 24 73508 23850 31599962
Full blood count decreased 11.30 11.04 13 73519 16527 31607285
Pancreatic carcinoma 11.27 11.04 3 73529 8597 31615215
Repetitive speech 11.25 11.04 5 73527 82 31623730
Productive cough 11.20 11.04 40 73492 33500 31590312
Haematochezia 11.17 11.04 52 73480 40412 31583400
Anorgasmia 11.15 11.04 11 73521 729 31623083
Univentricular heart 11.15 11.04 4 73528 36 31623776
Flight of ideas 11.11 11.04 8 73524 342 31623470
Tension headache 11.11 11.04 15 73517 1396 31622416
Neonatal hypotension 11.10 11.04 6 73526 153 31623659
Naevus flammeus 11.10 11.04 6 73526 153 31623659
Saccadic eye movement 11.07 11.04 6 73526 154 31623658
Hepatotoxicity 11.07 11.04 17 73515 19109 31604703
Craniocerebral injury 11.06 11.04 22 73510 2828 31620984
Small intestinal obstruction 11.05 11.04 9 73523 13463 31610349

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2048.80 9.88 2863 199678 224272 70501631
Serotonin syndrome 1488.54 9.88 1114 201427 41000 70684903
Intentional overdose 1258.12 9.88 1477 201064 96958 70628945
Suicide attempt 1153.11 9.88 1274 201267 78236 70647667
Toxicity to various agents 1129.99 9.88 2996 199545 379176 70346727
Suicidal ideation 972.67 9.88 1094 201447 68502 70657401
Drug withdrawal syndrome 912.98 9.88 753 201788 31962 70693941
Overdose 831.13 9.88 1627 200914 168118 70557785
Depression 758.83 9.88 1722 200819 197252 70528651
Drug abuse 576.15 9.88 1288 201253 145968 70579935
Poisoning deliberate 559.88 9.88 432 202109 16628 70709275
Intentional self-injury 530.54 9.88 548 201993 31102 70694801
Withdrawal syndrome 492.86 9.88 472 202069 24432 70701471
Coma 480.44 9.88 906 201635 90938 70634965
Sopor 454.54 9.88 502 202039 30765 70695138
Anxiety 442.17 9.88 1509 201032 218821 70507082
Drug interaction 424.09 9.88 2179 200362 379262 70346641
Agitation 375.37 9.88 826 201715 92549 70633354
Mydriasis 351.96 9.88 323 202218 15830 70710073
Hyperhidrosis 333.23 9.88 977 201564 130609 70595294
Tremor 328.01 9.88 1084 201457 154540 70571363
Rheumatoid arthritis 322.56 9.88 219 202322 291586 70434317
Somnolence 304.39 9.88 1321 201220 214285 70511618
Electrocardiogram QT prolonged 288.44 9.88 696 201845 82821 70643082
Synovitis 274.34 9.88 26 202515 129202 70596701
Febrile neutropenia 254.29 9.88 133 202408 204185 70521718
Depressed mood 236.13 9.88 438 202103 43382 70682521
Joint swelling 223.41 9.88 236 202305 252975 70472928
Seizure 218.72 9.88 1047 201494 176915 70548988
Disturbance in attention 217.79 9.88 418 202123 42476 70683427
Akathisia 217.13 9.88 219 202322 12074 70713829
Nightmare 210.37 9.88 287 202254 21869 70704034
Irritability 207.11 9.88 383 202158 37842 70688061
Pneumonia 206.85 9.88 938 201603 595294 70130609
Hand deformity 201.87 9.88 11 202530 86471 70639432
Crying 195.85 9.88 271 202270 20928 70704975
Infusion related reaction 191.77 9.88 169 202372 197365 70528538
Contraindicated product administered 185.44 9.88 76 202465 134536 70591367
Pyrexia 184.01 9.88 1001 201540 605951 70119952
Major depression 178.17 9.88 167 202374 8407 70717496
Mania 169.95 9.88 227 202314 16947 70708956
Restlessness 166.16 9.88 370 202171 41758 70684145
Anaemia 165.99 9.88 593 201948 402830 70323073
Sepsis 165.63 9.88 277 202264 244268 70481635
Rash 163.61 9.88 826 201715 509736 70216167
Systemic lupus erythematosus 162.14 9.88 45 202496 101857 70624046
Pericarditis 160.26 9.88 25 202516 84680 70641223
Feeling abnormal 159.63 9.88 816 201725 141503 70584400
Poisoning 153 9.88 250 202291 22372 70703531
Infection 150.99 9.88 230 202311 210555 70515348
Anger 150.18 9.88 207 202334 15925 70709978
Off label use 146.52 9.88 1387 201154 741673 69984230
Drug dependence 144.07 9.88 325 202216 36996 70688907
Panic attack 142.29 9.88 239 202302 21880 70704023
Arthropathy 137.78 9.88 135 202406 149922 70575981
Generalised tonic-clonic seizure 137.18 9.88 341 202200 41320 70684583
Glossodynia 134.26 9.88 40 202501 86447 70639456
Insomnia 134.07 9.88 1072 201469 216734 70509169
Neutropenia 133.68 9.88 339 202202 256817 70469086
Cataplexy 133.65 9.88 63 202478 956 70724947
Duodenal ulcer perforation 131.35 9.88 3 202538 51109 70674794
Cardio-respiratory arrest 130.65 9.88 602 201939 100075 70625828
Tachycardia 127.38 9.88 832 201709 157714 70568189
Platelet count decreased 125.19 9.88 197 202344 178025 70547878
Helicobacter infection 124.14 9.88 9 202532 55647 70670256
Rheumatoid factor positive 123.76 9.88 3 202538 48397 70677506
Psychomotor hyperactivity 121.66 9.88 183 202358 15250 70710653
Drug hypersensitivity 121.53 9.88 1214 201327 261245 70464658
Stress cardiomyopathy 120.82 9.88 145 202396 9717 70716186
Hypersensitivity 117.09 9.88 306 202235 229506 70496397
Altered state of consciousness 116.73 9.88 313 202228 39709 70686194
Stomatitis 116.38 9.88 117 202424 128394 70597509
Disease progression 115.03 9.88 168 202373 156504 70569399
Respiratory arrest 114.64 9.88 377 202164 53556 70672347
Homicide 113.75 9.88 59 202482 1111 70724792
Aggression 111.47 9.88 348 202193 48098 70677805
Muscle rigidity 111.39 9.88 195 202346 18455 70707448
Swelling 111.31 9.88 232 202309 188307 70537596
Sedation 109.67 9.88 338 202203 46393 70679510
Cardiac arrest 108.50 9.88 805 201736 159029 70566874
Confusional state 107.81 9.88 1264 201277 283134 70442769
Extrapyramidal disorder 107.51 9.88 204 202337 20546 70705357
Hyperreflexia 107.28 9.88 119 202422 7323 70718580
Bipolar disorder 106.83 9.88 120 202421 7488 70718415
Thrombocytopenia 106.72 9.88 339 202202 238771 70487132
Gestational diabetes 106.14 9.88 107 202434 5894 70720009
Alopecia 105.98 9.88 258 202283 198232 70527671
Malignant neoplasm progression 105.55 9.88 115 202426 121624 70604279
Tearfulness 102.82 9.88 97 202444 4923 70720980
Intentional product misuse 102.56 9.88 475 202066 79120 70646783
Electrocardiogram QRS complex prolonged 102.25 9.88 133 202408 9673 70716230
Renal impairment 100.22 9.88 160 202381 143777 70582126
Treatment failure 99.64 9.88 161 202380 143981 70581922
Myoclonus 98.93 9.88 227 202314 26128 70699775
Migraine 98.22 9.88 438 202103 71800 70654103
Delusion 97.55 9.88 187 202354 18978 70706925
Wound 97.54 9.88 83 202458 98649 70627254
Disorientation 96.65 9.88 374 202167 57549 70668354
Acute kidney injury 92.82 9.88 887 201654 473737 70252166
Product substitution issue 91.00 9.88 178 202363 18335 70707568
Mood swings 90.11 9.88 176 202365 18110 70707793
C-reactive protein abnormal 89.73 9.88 5 202536 38574 70687329
Hallucination, visual 88.15 9.88 232 202309 29105 70696798
Arthralgia 88.06 9.88 966 201575 502424 70223479
Dyspnoea 84.79 9.88 1620 200921 768440 69957463
Plasma cell myeloma 84.75 9.88 52 202489 73149 70652754
Tardive dyskinesia 84.41 9.88 122 202419 9807 70716096
Haemoglobin decreased 82.61 9.88 304 202237 204855 70521048
Pancytopenia 81.75 9.88 195 202346 150912 70574991
Hallucination, auditory 81.47 9.88 169 202372 18159 70707744
Nervousness 80.51 9.88 233 202308 30887 70695016
Neuroleptic malignant syndrome 79.50 9.88 207 202334 25800 70700103
Somnambulism 79.10 9.88 86 202455 5174 70720729
Therapeutic product effect decreased 78.62 9.88 183 202358 142835 70583068
Restless legs syndrome 78.52 9.88 167 202374 18261 70707642
Muscle injury 78.42 9.88 9 202532 38485 70687418
Diarrhoea 77.56 9.88 1677 200864 781664 69944239
Dyskinesia 77.54 9.88 276 202265 40798 70685105
Peripheral swelling 77.12 9.88 380 202161 236183 70489720
Antidepressant drug level above therapeutic 76.85 9.88 37 202504 590 70725313
Loss of consciousness 76.25 9.88 729 201812 154987 70570916
Parkinsonism 76.12 9.88 148 202393 15177 70710726
Decorticate posture 75.93 9.88 30 202511 287 70725616
Sleep-related eating disorder 75.45 9.88 38 202503 671 70725232
Thinking abnormal 74.58 9.88 128 202413 11923 70713980
Myocardial depression 74.19 9.88 34 202507 482 70725421
Abnormal behaviour 74.09 9.88 243 202298 34466 70691437
Paraesthesia 74.08 9.88 687 201854 144850 70581053
Self-injurious ideation 73.19 9.88 67 202474 3271 70722632
Septic shock 72.42 9.88 131 202410 112127 70613776
Antidepressant drug level increased 72.25 9.88 31 202510 372 70725531
Sinus tachycardia 72.00 9.88 237 202304 33676 70692227
Bone marrow failure 71.92 9.88 25 202516 48985 70676918
Postmortem blood drug level increased 71.89 9.88 38 202503 745 70725158
Mental disorder 70.72 9.88 209 202332 28031 70697872
Memory impairment 70.63 9.88 480 202061 92161 70633742
Gastrointestinal haemorrhage 69.91 9.88 183 202358 137225 70588678
Psychotic symptom 69.82 9.88 57 202484 2381 70723522
Impaired healing 69.30 9.88 66 202475 74308 70651595
Folliculitis 69.21 9.88 18 202523 42552 70683351
Blister 68.78 9.88 113 202428 100413 70625490
Psychotic disorder 68.33 9.88 250 202291 37451 70688452
Pleural effusion 68.32 9.88 176 202365 132688 70593215
Homicidal ideation 67.66 9.88 64 202477 3259 70722644
Hypomania 67.47 9.88 85 202456 5987 70719916
Lung diffusion test abnormal 66.81 9.88 26 202515 238 70725665
Atrial fibrillation 66.68 9.88 285 202256 184063 70541840
Mental impairment 66.29 9.88 150 202391 17105 70708798
Abnormal dreams 66.11 9.88 113 202428 10490 70715413
Discomfort 65.40 9.88 126 202415 105310 70620593
Galactorrhoea 64.88 9.88 63 202478 3315 70722588
Cytomegalovirus infection 64.27 9.88 17 202524 39741 70686162
Hepatic enzyme increased 64.25 9.88 231 202310 156759 70569144
Apathy 64.09 9.88 119 202422 11789 70714114
Camptocormia 63.89 9.88 30 202511 451 70725452
Blood creatinine increased 63.57 9.88 203 202338 142798 70583105
Physical assault 63.43 9.88 45 202496 1519 70724384
Urinary incontinence 62.84 9.88 244 202297 37598 70688305
Amnesia 62.62 9.88 305 202236 51850 70674053
Sleep disorder due to general medical condition, insomnia type 62.27 9.88 13 202528 35719 70690184
Neuropathy peripheral 60.07 9.88 175 202366 126721 70599182
Meconium in amniotic fluid 59.14 9.88 18 202523 70 70725833
Respiratory failure 59.12 9.88 264 202277 168471 70557432
Pneumocystis jirovecii pneumonia 58.93 9.88 8 202533 30074 70695829
Suicidal behaviour 58.70 9.88 57 202484 2999 70722904
Mood altered 58.65 9.88 139 202402 16336 70709567
Psychomotor retardation 58.48 9.88 76 202465 5522 70720381
Abdominal discomfort 58.38 9.88 366 202175 214292 70511611
Coma scale abnormal 58.03 9.88 92 202449 8024 70717879
Impulsive behaviour 57.91 9.88 54 202487 2700 70723203
Logorrhoea 56.25 9.88 64 202477 4050 70721853
Clonus 56.20 9.88 79 202462 6189 70719714
Euphoric mood 56.17 9.88 83 202458 6806 70719097
Sinusitis 55.57 9.88 271 202270 168924 70556979
Nasopharyngitis 55.34 9.88 389 202152 221817 70504086
Libido decreased 54.92 9.88 69 202472 4847 70721056
Muscle twitching 54.75 9.88 152 202389 19675 70706228
Myelosuppression 54.57 9.88 10 202531 30135 70695768
C-reactive protein increased 54.09 9.88 150 202391 110367 70615536
Hypertonia 54.01 9.88 79 202462 6419 70719484
Mobility decreased 53.28 9.88 136 202405 102863 70623040
Hallucination 52.79 9.88 386 202155 75874 70650029
Bruxism 52.67 9.88 59 202482 3670 70722233
Dizziness 52.48 9.88 1714 200827 462427 70263476
Dissociation 52.17 9.88 56 202485 3320 70722583
Cytokine release syndrome 51.94 9.88 7 202534 26460 70699443
Erythema 51.85 9.88 345 202196 199218 70526685
Maternal exposure during pregnancy 51.78 9.88 163 202378 115182 70610721
Vertigo 51.63 9.88 331 202210 62312 70663591
Lymphocytic oesophagitis 51.54 9.88 13 202528 19 70725884
Feelings of worthlessness 50.83 9.88 26 202515 475 70725428
Oedema 50.38 9.88 141 202400 103440 70622463
Irritable bowel syndrome 49.90 9.88 43 202498 50807 70675096
Hepatic function abnormal 49.79 9.88 73 202468 67923 70657980
Benzodiazepine drug level increased 49.41 9.88 20 202521 205 70725698
Ascites 48.99 9.88 73 202468 67474 70658429
Psoriatic arthropathy 48.95 9.88 68 202473 64703 70661200
Dysphoria 48.45 9.88 62 202479 4436 70721467
Pain 48.34 9.88 1397 201144 627419 70098484
Erectile dysfunction 47.82 9.88 114 202427 13448 70712455
Emotional disorder 47.53 9.88 112 202429 13114 70712789
Depressive symptom 47.50 9.88 66 202475 5115 70720788
Product use issue 47.28 9.88 310 202231 179627 70546276
Inappropriate affect 47.26 9.88 36 202505 1358 70724545
Accommodation disorder 46.85 9.88 25 202516 500 70725403
Oedema peripheral 46.74 9.88 421 202120 227670 70498233
Neovascularisation 46.56 9.88 33 202508 1112 70724791
Foetal death 46.38 9.88 72 202469 6167 70719736
Toxic epidermal necrolysis 45.92 9.88 28 202513 39529 70686374
Pyramidal tract syndrome 45.76 9.88 25 202516 525 70725378
Cardiac failure 45.36 9.88 233 202308 143308 70582595
Persecutory delusion 45.14 9.88 60 202481 4457 70721446
Weight increased 44.48 9.88 954 201587 241377 70484526
White blood cell count decreased 44.26 9.88 294 202247 169847 70556056
Interstitial lung disease 44.18 9.88 152 202389 104533 70621370
Hot flush 43.99 9.88 267 202274 49317 70676586
Lower respiratory tract infection 43.60 9.88 168 202373 111745 70614158
Anticholinergic syndrome 43.55 9.88 48 202493 2932 70722971
Paranoia 43.33 9.88 128 202413 17160 70708743
Loss of libido 43.21 9.88 44 202497 2453 70723450
Delirium 43.00 9.88 362 202179 74252 70651651
Anaphylactic reaction 42.76 9.88 94 202447 74880 70651023
General physical health deterioration 42.74 9.88 449 202092 235582 70490321
Social anxiety disorder 42.57 9.88 23 202518 472 70725431
Feeling jittery 41.76 9.88 98 202443 11445 70714458
Hyperkalaemia 41.53 9.88 160 202381 106431 70619472
Pleurothotonus 41.50 9.88 42 202499 2324 70723579
Drug screen positive 41.48 9.88 66 202475 5774 70720129
Obsessive-compulsive disorder 41.36 9.88 63 202478 5307 70720596
Hostility 41.34 9.88 41 202500 2214 70723689
Mucosal inflammation 41.27 9.88 82 202459 67768 70658135
Gastrointestinal disorder 41.24 9.88 158 202383 105269 70620634
Anorgasmia 41.21 9.88 30 202511 1055 70724848
Personality disorder 41.20 9.88 64 202477 5484 70720419
Miosis 40.82 9.88 110 202431 13991 70711912
Abulia 40.48 9.88 28 202513 907 70724996
Cerebral infarction 40.26 9.88 38 202503 42971 70682932
Inappropriate antidiuretic hormone secretion 40.22 9.88 152 202389 23124 70702779
Red blood cell sedimentation rate increased 40.00 9.88 31 202510 38611 70687292
Panic disorder 39.91 9.88 45 202496 2819 70723084
Cardiogenic shock 39.83 9.88 207 202334 36100 70689803
Malignant mediastinal neoplasm 39.76 9.88 27 202514 848 70725055
Epilepsy 39.74 9.88 217 202324 38567 70687336
Sleep disorder 39.74 9.88 338 202203 69534 70656369
Cough 39.57 9.88 672 201869 324705 70401198
Respiratory depression 39.52 9.88 158 202383 24673 70701230
Persistent genital arousal disorder 39.52 9.88 19 202522 302 70725601
Prostate cancer 39.14 9.88 20 202521 31143 70694760
Fluid retention 39.08 9.88 76 202465 63309 70662594
Hereditary non-polyposis colorectal cancer syndrome 38.89 9.88 8 202533 0 70725903
Antipsychotic drug level above therapeutic 38.18 9.88 37 202504 1942 70723961
Libido increased 38.06 9.88 36 202505 1833 70724070
Cardiac failure congestive 37.83 9.88 229 202312 135228 70590675
Fall 37.80 9.88 1589 200952 442507 70283396
Persistent depressive disorder 37.77 9.88 28 202513 1013 70724890
Blood bilirubin increased 37.65 9.88 71 202470 59830 70666073
Feeling of despair 37.54 9.88 42 202499 2609 70723294
Tinnitus 37.46 9.88 203 202338 35973 70689930
Reversible cerebral vasoconstriction syndrome 37.10 9.88 42 202499 2643 70723260
Drug intolerance 37.03 9.88 439 202102 225248 70500655
Ill-defined disorder 37.00 9.88 62 202479 54679 70671224
Amniorrhexis 36.74 9.88 10 202531 23 70725880
Hip arthroplasty 36.74 9.88 17 202524 28023 70697880
Metabolic syndrome 36.41 9.88 40 202501 2435 70723468
Social avoidant behaviour 36.40 9.88 55 202486 4601 70721302
Sexual dysfunction 36.25 9.88 67 202474 6614 70719289
Opsoclonus myoclonus 35.95 9.88 16 202525 211 70725692
Self esteem decreased 35.90 9.88 26 202515 907 70724996
Bronchopulmonary aspergillosis 35.86 9.88 8 202533 20994 70704909
Cardiotoxicity 35.79 9.88 90 202451 10980 70714923
Acute myeloid leukaemia 35.78 9.88 22 202519 30918 70694985
Hyponatraemia 35.67 9.88 649 201892 159438 70566465
Congestive cardiomyopathy 35.50 9.88 89 202452 10837 70715066
Endometriosis 35.48 9.88 45 202496 3191 70722712
Hypersomnia 35.38 9.88 135 202406 20629 70705274
Suspected suicide 35.28 9.88 78 202463 8756 70717147
Death 35.26 9.88 1149 201392 508912 70216991
Bezoar 35.19 9.88 38 202503 2268 70723635
Tumour lysis syndrome 34.78 9.88 9 202532 21351 70704552
Adjustment disorder with mixed anxiety and depressed mood 34.78 9.88 12 202529 75 70725828
Drug eruption 34.56 9.88 37 202504 39459 70686444
International normalised ratio increased 34.21 9.88 117 202424 80609 70645294
Nephropathy toxic 33.82 9.88 6 202535 18508 70707395
Toxicologic test abnormal 33.81 9.88 29 202512 1298 70724605
Somatic symptom disorder 33.73 9.88 35 202506 1995 70723908
Urinary retention 33.61 9.88 261 202280 52259 70673644
Hypothermia 33.55 9.88 132 202409 20462 70705441
Drug screen false positive 33.54 9.88 26 202515 1007 70724896
Neutrophil count decreased 33.47 9.88 124 202417 83432 70642471
Nystagmus 33.38 9.88 79 202462 9276 70716627
Negative thoughts 33.38 9.88 29 202512 1321 70724582
Total lung capacity increased 33.35 9.88 25 202516 920 70724983
Middle insomnia 33.29 9.88 102 202439 13951 70711952
Leukopenia 33.08 9.88 174 202367 106386 70619517
Tachyphrenia 33.07 9.88 34 202507 1917 70723986
Haematuria 32.83 9.88 84 202457 63489 70662414
Victim of sexual abuse 32.58 9.88 19 202522 454 70725449
Cognitive disorder 32.13 9.88 290 202251 60666 70665237
Rheumatoid nodule 32.04 9.88 3 202538 15064 70710839
Myelodysplastic syndrome 31.98 9.88 23 202518 29762 70696141
Pruritus 31.97 9.88 747 201794 344813 70381090
Postmortem blood drug level abnormal 31.83 9.88 21 202520 628 70725275
Pneumonitis 31.50 9.88 68 202473 54529 70671374
Tubulointerstitial nephritis 31.22 9.88 29 202512 33047 70692856
Bipolar II disorder 30.95 9.88 17 202524 361 70725542
Colitis 30.93 9.88 87 202454 63727 70662176
Transplant rejection 30.87 9.88 7 202534 18164 70707739
Acute myocardial infarction 30.64 9.88 106 202435 72781 70653122
Intentional product use issue 30.54 9.88 209 202332 119933 70605970
Rhabdomyolysis 30.38 9.88 412 202129 95348 70630555
Head discomfort 30.36 9.88 94 202447 12929 70712974
Bradyphrenia 30.23 9.88 79 202462 9867 70716036
Derealisation 30.16 9.88 29 202512 1507 70724396
Skin candida 30.06 9.88 31 202510 1754 70724149
HELLP syndrome 30.01 9.88 21 202520 693 70725210
Speech disorder 29.99 9.88 247 202294 50333 70675570
Panic reaction 29.96 9.88 48 202493 4223 70721680
Alcoholism 29.88 9.88 49 202492 4396 70721507
Bacteraemia 29.72 9.88 24 202517 29285 70696618
Parkinsonism hyperpyrexia syndrome 29.43 9.88 14 202527 217 70725686
Tension 29.30 9.88 46 202495 3978 70721925
Endolymphatic hydrops 29.17 9.88 6 202535 0 70725903
Tenosynovitis 29.15 9.88 3 202538 13973 70711930
Cytopenia 28.78 9.88 7 202534 17316 70708587
Rapid eye movement sleep behaviour disorder 28.74 9.88 16 202525 349 70725554
Substance abuse 28.74 9.88 77 202464 9760 70716143
Kleptomania 28.65 9.88 8 202533 21 70725882
Dependence 28.47 9.88 34 202507 2266 70723637
Haematotoxicity 28.35 9.88 3 202538 13671 70712232
Hypocalcaemia 28.34 9.88 53 202488 44806 70681097
Depression suicidal 28.31 9.88 38 202503 2849 70723054
Renal failure 28.30 9.88 375 202166 188695 70537208
Ejaculation disorder 28.27 9.88 18 202523 506 70725397
Skin necrosis 28.24 9.88 6 202535 16285 70709618
Osteonecrosis of jaw 28.12 9.88 46 202495 40956 70684947
Unemployment 28.09 9.88 9 202532 43 70725860
Product residue present 28.05 9.88 41 202500 3329 70722574
Enuresis 28.01 9.88 38 202503 2879 70723024
Palmar-plantar erythrodysaesthesia syndrome 27.99 9.88 27 202514 30220 70695683
Multiple organ dysfunction syndrome 27.96 9.88 188 202353 108327 70617576
Macrophages increased 27.89 9.88 13 202528 192 70725711
Liver disorder 27.63 9.88 87 202454 61481 70664422
Diverticulitis 27.54 9.88 48 202493 41686 70684217
Full blood count abnormal 27.29 9.88 178 202363 33700 70692203
Affect lability 27.24 9.88 77 202464 10069 70715834
Drug use disorder 27.12 9.88 67 202474 8084 70717819
Epstein-Barr virus infection 27.10 9.88 3 202538 13195 70712708
Iodine allergy 27.06 9.88 18 202523 546 70725357
Alcohol interaction 26.94 9.88 48 202493 4605 70721298
Right ventricular failure 26.94 9.88 15 202526 22259 70703644
COVID-19 26.86 9.88 184 202357 105573 70620330
Nervous system disorder 26.72 9.88 138 202403 24008 70701895
Upper respiratory tract infection 26.57 9.88 126 202415 79148 70646755
Tonic convulsion 26.38 9.88 31 202510 2031 70723872
Antipsychotic drug level increased 26.36 9.88 52 202489 5388 70720515
Pulmonary arterial hypertension 26.35 9.88 33 202508 32822 70693081
Hepatocellular injury 26.22 9.88 223 202318 45868 70680035
Cogwheel rigidity 26.01 9.88 37 202504 2931 70722972
Decreased interest 25.98 9.88 40 202501 3401 70722502
Dysarthria 25.82 9.88 282 202259 62031 70663872
Psychiatric symptom 25.79 9.88 58 202483 6586 70719317
Thermophobia 25.72 9.88 9 202532 59 70725844
Drug ineffective for unapproved indication 25.49 9.88 193 202348 38345 70687558
Affective disorder 25.44 9.88 62 202479 7417 70718486
Pain in extremity 25.34 9.88 728 201813 327354 70398549
Feeling drunk 25.22 9.88 45 202496 4322 70721581
Musculoskeletal stiffness 25.16 9.88 285 202256 147475 70578428
Pressure of speech 25.12 9.88 22 202519 1013 70724890
Diffuse large B-cell lymphoma 24.98 9.88 4 202537 13298 70712605
Headache 24.97 9.88 1952 200589 578453 70147450
Pathogen resistance 24.93 9.88 4 202537 13275 70712628
Respiratory tract inflammation 24.92 9.88 20 202521 815 70725088
Colitis microscopic 24.83 9.88 69 202472 8936 70716967
Vision blurred 24.75 9.88 395 202146 94589 70631314
Reduced facial expression 24.68 9.88 32 202509 2320 70723583
Thrombosis 24.61 9.88 121 202420 75284 70650619
Schizophreniform disorder 24.52 9.88 11 202530 148 70725755
Brain death 24.50 9.88 49 202492 5129 70720774
Hospitalisation 24.42 9.88 137 202404 82431 70643472
Yawning 24.40 9.88 24 202517 1283 70724620
Phagophobia 24.35 9.88 8 202533 42 70725861
ECG P wave inverted 24.31 9.88 5 202536 0 70725903
Electrocardiogram QRS complex shortened 24.19 9.88 18 202523 655 70725248
Lung disorder 24.14 9.88 109 202432 69375 70656528
Substance abuser 24.13 9.88 11 202530 154 70725749
Frustration tolerance decreased 24.00 9.88 57 202484 6708 70719195
Tongue biting 23.99 9.88 28 202513 1821 70724082
Heart rate increased 23.87 9.88 431 202110 105717 70620186
Herpes zoster 23.84 9.88 144 202397 85091 70640812
Electric shock sensation 23.75 9.88 17 202524 582 70725321
Aplastic anaemia 23.72 9.88 9 202532 16707 70709196
Hyperprolactinaemia 23.62 9.88 44 202497 4369 70721534
Therapeutic response unexpected 23.61 9.88 109 202432 18122 70707781
Abnormal weight gain 23.61 9.88 31 202510 2275 70723628
Eye movement disorder 23.54 9.88 60 202481 7380 70718523
Stress 23.47 9.88 297 202244 67669 70658234
Hyperthermia 23.34 9.88 102 202439 16569 70709334
Antidepressant discontinuation syndrome 23.31 9.88 6 202535 10 70725893
Neurodegenerative disorder 23.24 9.88 15 202526 432 70725471
Renal papillary necrosis 23.23 9.88 14 202527 356 70725547
Neoplasm progression 23.17 9.88 60 202481 45168 70680735
Kidney duplex 22.95 9.88 6 202535 11 70725892
Merycism 22.95 9.88 12 202529 230 70725673
Coma acidotic 22.94 9.88 10 202531 125 70725778
Vasoplegia syndrome 22.87 9.88 36 202505 3120 70722783
Blood urea increased 22.68 9.88 62 202479 45847 70680056
Haemophagocytic lymphohistiocytosis 22.60 9.88 14 202527 19598 70706305
Drug abuser 22.55 9.88 51 202490 5813 70720090
Balance disorder 22.44 9.88 372 202169 89756 70636147
Peritonitis 22.34 9.88 25 202516 26134 70699769
Transfusion 22.33 9.88 13 202528 18823 70707080
Poor quality sleep 22.31 9.88 116 202425 20233 70705670
Loose associations 22.29 9.88 8 202533 57 70725846
External auditory canal atresia 22.29 9.88 6 202535 13 70725890
Haemolytic anaemia 22.28 9.88 10 202531 16784 70709119
Haemoptysis 22.19 9.88 74 202467 51378 70674525
Cardiomyopathy 22.13 9.88 140 202401 26233 70699670
Narcolepsy 22.11 9.88 22 202519 1193 70724710
Sleep terror 22.11 9.88 22 202519 1193 70724710
Joint range of motion decreased 22.09 9.88 25 202516 26001 70699902
Iris coloboma 21.98 9.88 6 202535 14 70725889
Retinal coloboma 21.98 9.88 6 202535 14 70725889
Neurotoxicity 21.85 9.88 32 202509 29794 70696109
Erythema dyschromicum perstans 21.83 9.88 8 202533 61 70725842
Asphyxia 21.70 9.88 72 202469 10270 70715633
Thrombotic microangiopathy 21.62 9.88 12 202529 17836 70708067
Cold sweat 21.50 9.88 101 202440 16915 70708988
Graft versus host disease 21.47 9.88 8 202533 15015 70710888
Liver function test increased 21.37 9.88 40 202501 33807 70692096
Cataract 21.37 9.88 84 202457 55561 70670342
Hepatotoxicity 21.29 9.88 60 202481 43926 70681977
Device related infection 21.25 9.88 37 202504 32148 70693755
Sleep paralysis 21.20 9.88 16 202525 595 70725308
Incoherent 21.16 9.88 57 202484 7249 70718654
Otospondylomegaepiphyseal dysplasia 21.11 9.88 7 202534 38 70725865
Obsessive thoughts 21.07 9.88 20 202521 1023 70724880
Splenomegaly 21.02 9.88 14 202527 18856 70707047
Testicular atrophy 21.01 9.88 13 202528 347 70725556
Acquired amegakaryocytic thrombocytopenia 20.90 9.88 6 202535 18 70725885
Blood lactate dehydrogenase increased 20.89 9.88 43 202498 35084 70690819
Cytomegalovirus viraemia 20.88 9.88 4 202537 11681 70714222
Hepatic failure 20.87 9.88 89 202452 57536 70668367
Helplessness 20.78 9.88 13 202528 354 70725549
Phaeochromocytoma malignant 20.68 9.88 8 202533 72 70725831
Dialysis 20.65 9.88 12 202529 17390 70708513
Osteoporosis 20.64 9.88 71 202470 48836 70677067
Muscle mass 20.61 9.88 14 202527 440 70725463
Paradoxical drug reaction 20.46 9.88 53 202488 6583 70719320
Bradypnoea 20.46 9.88 47 202494 5412 70720491
Pulmonary pain 20.41 9.88 36 202505 3426 70722477
Skin maceration 20.39 9.88 7 202534 43 70725860
Concussion 20.38 9.88 62 202479 8447 70717456
Second primary malignancy 20.31 9.88 6 202535 13045 70712858
Palpitations 20.28 9.88 436 202105 110317 70615586
Flight of ideas 20.24 9.88 17 202524 739 70725164
Trunk injury 20.20 9.88 6 202535 21 70725882
Hypervigilance 20.20 9.88 14 202527 455 70725448
Catatonia 20.18 9.88 60 202481 8073 70717830
Emotional poverty 20.16 9.88 17 202524 743 70725160
Foaming at mouth 20.09 9.88 25 202516 1739 70724164
Cellulitis 20.07 9.88 183 202358 98745 70627158
External ear disorder 20.03 9.88 8 202533 79 70725824
Blood creatine phosphokinase increased 20.01 9.88 265 202276 60998 70664905
Food aversion 19.99 9.88 17 202524 752 70725151
Dry mouth 19.89 9.88 297 202244 70160 70655743
COVID-19 pneumonia 19.88 9.88 20 202521 21949 70703954
Burnout syndrome 19.85 9.88 12 202529 307 70725596
Melaena 19.82 9.88 88 202453 56267 70669636
Distributive shock 19.77 9.88 28 202513 2209 70723694
Histamine level increased 19.76 9.88 8 202533 82 70725821
Increased appetite 19.76 9.88 71 202470 10542 70715361
Hypercalcaemia 19.69 9.88 43 202498 34342 70691561
Hyperchloraemia 19.67 9.88 19 202522 993 70724910
Respiratory tract infection 19.67 9.88 59 202482 42339 70683564
False positive investigation result 19.64 9.88 18 202523 880 70725023
Disturbance in sexual arousal 19.63 9.88 10 202531 181 70725722
Starvation ketoacidosis 19.61 9.88 9 202532 128 70725775
Perinatal depression 19.61 9.88 12 202529 314 70725589
Clostridium difficile infection 19.49 9.88 52 202489 38764 70687139
Basal cell carcinoma 19.42 9.88 42 202499 33656 70692247
Urticaria 19.39 9.88 338 202203 162711 70563192
Drug resistance 19.30 9.88 51 202490 38139 70687764
Pneumonia bacterial 19.01 9.88 12 202529 16629 70709274
Soft tissue injury 18.97 9.88 24 202517 1698 70724205
Enthesopathy 18.84 9.88 4 202537 10865 70715038
Creatinine renal clearance decreased 18.84 9.88 13 202528 17187 70708716
Micturition urgency 18.82 9.88 73 202468 11241 70714662
Activation syndrome 18.71 9.88 11 202530 267 70725636
Pre-existing condition improved 18.68 9.88 43 202498 4959 70720944
Depressed level of consciousness 18.61 9.88 352 202189 87079 70638824
Sciatic nerve neuropathy 18.49 9.88 12 202529 349 70725554
Ocular hyperaemia 18.48 9.88 26 202515 24613 70701290
Orthostatic intolerance 18.48 9.88 24 202517 1743 70724160
Impaired driving ability 18.41 9.88 42 202499 4815 70721088
Proteinuria 18.29 9.88 35 202506 29339 70696564
Nodule 18.27 9.88 18 202523 19951 70705952
Generalised oedema 18.26 9.88 21 202520 21687 70704216
Gambling disorder 18.23 9.88 25 202516 1913 70723990
Abnormal sleep-related event 18.21 9.88 17 202524 851 70725052
Imprisonment 18.18 9.88 14 202527 537 70725366
Muscle tightness 18.05 9.88 74 202467 11688 70714215
Dystonia 18.04 9.88 107 202434 19599 70706304
Gambling 18.00 9.88 11 202530 287 70725616
Oropharyngeal pain 17.91 9.88 182 202359 96128 70629775
Transient psychosis 17.81 9.88 7 202534 66 70725837
Eosinophilic pustular folliculitis 17.81 9.88 8 202533 108 70725795
Vitamin K decreased 17.71 9.88 7 202534 67 70725836
Wrong dose 17.70 9.88 21 202520 1390 70724513
Incontinence 17.70 9.88 79 202462 12949 70712954
Anhedonia 17.69 9.88 84 202457 14129 70711774
Micturition disorder 17.65 9.88 35 202506 3640 70722263
Myocardial infarction 17.58 9.88 365 202176 171280 70554623
Attention deficit hyperactivity disorder 17.54 9.88 31 202510 2956 70722947
Adrenal insufficiency 17.53 9.88 28 202513 25167 70700736
Hypokinesia 17.50 9.88 97 202444 17335 70708568
Wheezing 17.49 9.88 178 202363 93992 70631911
Drug level increased 17.46 9.88 170 202371 36299 70689604
CYP3A4 polymorphism 17.44 9.88 7 202534 70 70725833
Metastases to bone 17.40 9.88 23 202518 22353 70703550
Normal pressure hydrocephalus 17.38 9.88 13 202528 477 70725426
Antisocial behaviour 17.35 9.88 14 202527 575 70725328
Bradykinesia 17.35 9.88 54 202487 7448 70718455
Accidental death 17.33 9.88 36 202505 3872 70722031
Slow response to stimuli 17.29 9.88 23 202518 1710 70724193
Dyspnoea exertional 17.28 9.88 142 202399 78288 70647615
Potentiating drug interaction 17.28 9.88 57 202484 8107 70717796
Priapism 17.22 9.88 37 202504 4073 70721830
Female sexual dysfunction 17.19 9.88 6 202535 39 70725864
Oesophageal carcinoma 17.18 9.88 3 202538 9363 70716540
Productive cough 17.18 9.88 142 202399 78195 70647708
Hyperacusis 17.17 9.88 25 202516 2023 70723880
Arachnoid cyst 17.16 9.88 11 202530 313 70725590
Emotional distress 17.15 9.88 172 202369 37016 70688887
Pulmonary mass 17.12 9.88 30 202511 26003 70699900
Skin ulcer 17.04 9.88 75 202466 48070 70677833
Cerebellar haematoma 17 9.88 14 202527 592 70725311
Localised infection 16.97 9.88 44 202497 33114 70692789
Ataxia 16.92 9.88 119 202422 23098 70702805
Sleep apnoea syndrome 16.91 9.88 155 202386 32558 70693345
Disseminated intravascular coagulation 16.88 9.88 45 202496 33553 70692350
Sluggishness 16.84 9.88 46 202495 5897 70720006
Dysphemia 16.80 9.88 32 202509 3231 70722672
Left ventricular dysfunction 16.76 9.88 98 202443 17859 70708044
Catecholamines urine increased 16.73 9.88 5 202536 18 70725885
Pericardial effusion 16.73 9.88 62 202479 41714 70684189
Purging 16.69 9.88 6 202535 43 70725860
Arthritis 16.67 9.88 189 202352 97791 70628112
Blood potassium increased 16.64 9.88 33 202508 27293 70698610
Therapy non-responder 16.61 9.88 140 202401 76775 70649128
Back pain 16.57 9.88 620 201921 270532 70455371
Fear 16.55 9.88 109 202432 20702 70705201
Injection site erythema 16.54 9.88 131 202410 72793 70653110
Hallucination, tactile 16.49 9.88 13 202528 516 70725387
Akinesia 16.49 9.88 31 202510 3100 70722803
Aspartate aminotransferase increased 16.48 9.88 259 202282 126719 70599184
Impaired work ability 16.45 9.88 91 202450 16249 70709654
Haematocrit decreased 16.40 9.88 96 202445 57162 70668741
Chest discomfort 16.38 9.88 253 202288 124128 70601775
Implant site extravasation 16.34 9.88 15 202526 735 70725168
Prescribed overdose 16.25 9.88 133 202408 27048 70698855
Pulmonary contusion 16.24 9.88 7 202534 85 70725818
Hypotonia 16.16 9.88 72 202469 11793 70714110
Anticonvulsant drug level above therapeutic 16.15 9.88 18 202523 1113 70724790
Cold agglutinins positive 16.12 9.88 6 202535 48 70725855
Delusional disorder, unspecified type 16.12 9.88 15 202526 748 70725155
Acute hepatitis B 16.10 9.88 12 202529 438 70725465
Upper gastrointestinal haemorrhage 16.09 9.88 54 202487 37423 70688480
Drug specific antibody 16.02 9.88 26 202515 2313 70723590
Jaundice 16.01 9.88 81 202460 50027 70675876
Blood ethanol increased 16.00 9.88 14 202527 644 70725259
Exposure via ingestion 15.93 9.88 40 202501 4875 70721028
Peak expiratory flow rate decreased 15.90 9.88 14 202527 649 70725254
Toxic cardiomyopathy 15.80 9.88 11 202530 360 70725543
Focal dyscognitive seizures 15.77 9.88 32 202509 3385 70722518
Blood calcium decreased 15.77 9.88 37 202504 28809 70697094
Male orgasmic disorder 15.71 9.88 6 202535 52 70725851
Conversion disorder 15.63 9.88 22 202519 1726 70724177
Alanine aminotransferase increased 15.58 9.88 312 202229 147168 70578735
Renal disorder 15.49 9.88 56 202485 37953 70687950
Cardiac failure chronic 15.48 9.88 5 202536 10264 70715639
Drug level above therapeutic 15.45 9.88 53 202488 7689 70718214
Aspergillus infection 15.34 9.88 17 202524 17851 70708052
Hepatocellular carcinoma 15.34 9.88 5 202536 10203 70715700
Cerebral vasoconstriction 15.28 9.88 19 202522 1321 70724582
Cystitis haemorrhagic 15.23 9.88 3 202538 8590 70717313
Injection site pain 15.23 9.88 240 202301 117379 70608524
Cerebral haematoma 15.16 9.88 51 202490 7327 70718576
Rhinorrhoea 15.16 9.88 119 202422 66252 70659651
Bladder trabeculation 15.13 9.88 6 202535 58 70725845
Conjunctivitis viral 15.13 9.88 8 202533 157 70725746
Pneumothorax 15.07 9.88 32 202509 25814 70700089
Trismus 15.03 9.88 40 202501 5051 70720852
Post-traumatic neck syndrome 14.99 9.88 23 202518 1950 70723953
Respiratory tract congestion 14.93 9.88 17 202524 17636 70708267
Ulcer 14.92 9.88 32 202509 25722 70700181
Inadequate analgesia 14.91 9.88 35 202506 4087 70721816
Rash pruritic 14.83 9.88 112 202429 62879 70663024
Kidney transplant rejection 14.75 9.88 5 202536 9956 70715947
Immunodeficiency 14.75 9.88 17 202524 17538 70708365
Cerebrovascular accident 14.72 9.88 305 202236 143165 70582738
Hypnopompic hallucination 14.69 9.88 6 202535 63 70725840
Tricuspid valve sclerosis 14.66 9.88 5 202536 30 70725873
Feeling guilty 14.59 9.88 15 202526 846 70725057
Sternal fracture 14.58 9.88 25 202516 2326 70723577
Parkinsonian gait 14.54 9.88 15 202526 849 70725054
Forced expiratory volume decreased 14.54 9.88 50 202491 7264 70718639
Blood catecholamines increased 14.53 9.88 5 202536 31 70725872
Hypoalbuminaemia 14.52 9.88 20 202521 19102 70706801
Genital hypoaesthesia 14.52 9.88 8 202533 171 70725732
Adverse drug reaction 14.46 9.88 91 202450 53253 70672650
Labour complication 14.45 9.88 6 202535 66 70725837
Neurological examination abnormal 14.44 9.88 12 202529 514 70725389
Metastases to central nervous system 14.40 9.88 13 202528 15021 70710882
Parasomnia 14.38 9.88 12 202529 517 70725386
Foot deformity 14.33 9.88 23 202518 20632 70705271
Apallic syndrome 14.27 9.88 15 202526 868 70725035
Depersonalisation/derealisation disorder 14.17 9.88 21 202520 1727 70724176
Tympanic membrane disorder 14.15 9.88 8 202533 180 70725723
Tendonitis 14.09 9.88 26 202515 22096 70703807
Eosinophilic myocarditis 14.07 9.88 15 202526 882 70725021
Decreased appetite 14.05 9.88 719 201822 304061 70421842
Multiple sclerosis relapse 14.02 9.88 186 202355 42831 70683072
Skin texture abnormal 13.97 9.88 11 202530 436 70725467
Anaemia of pregnancy 13.84 9.88 6 202535 74 70725829
Selective mutism 13.84 9.88 6 202535 74 70725829
Indifference 13.83 9.88 9 202532 263 70725640
Flashback 13.77 9.88 9 202532 265 70725638
Barotrauma 13.76 9.88 8 202533 190 70725713
Haemorrhage 13.74 9.88 163 202378 83652 70642251
Pulmonary fibrosis 13.68 9.88 51 202490 34259 70691644
Regressive behaviour 13.68 9.88 7 202534 128 70725775
Myopathy 13.60 9.88 20 202521 18592 70707311
Escherichia infection 13.52 9.88 16 202525 16315 70709588
Anal incontinence 13.50 9.88 87 202454 16403 70709500
Device malfunction 13.47 9.88 21 202520 19063 70706840
Food craving 13.38 9.88 19 202522 1502 70724401
Movement disorder 13.33 9.88 116 202425 24013 70701890
Alcohol use 13.30 9.88 36 202505 4591 70721312
Chronic kidney disease 13.24 9.88 111 202430 60946 70664957
Small intestinal obstruction 13.18 9.88 32 202509 24623 70701280
Multiple sclerosis 13.17 9.88 120 202421 25165 70700738
Violence-related symptom 13.15 9.88 13 202528 699 70725204
Judgement impaired 13.14 9.88 16 202525 1088 70724815
Pneumonia fungal 13.09 9.88 6 202535 9947 70715956
Adverse event 13.08 9.88 85 202456 49376 70676527
Device occlusion 13.01 9.88 7 202534 10588 70715315
Femur fracture 12.96 9.88 56 202485 36076 70689827
Peritonitis bacterial 12.94 9.88 5 202536 9179 70716724
Hyponatraemic coma 12.92 9.88 5 202536 45 70725858
Extrasystoles 12.81 9.88 46 202495 6828 70719075
Angle closure glaucoma 12.79 9.88 26 202515 2753 70723150
Metastases to lung 12.76 9.88 17 202524 16467 70709436
Pseudophaeochromocytoma 12.73 9.88 6 202535 91 70725812
Loose tooth 12.72 9.88 27 202514 2947 70722956
Bipolar I disorder 12.71 9.88 21 202520 1896 70724007
Hepatic cirrhosis 12.70 9.88 45 202496 30686 70695217
Torsade de pointes 12.70 9.88 92 202449 18024 70707879
Wrong technique in product usage process 12.69 9.88 130 202411 68568 70657335
Hypnagogic hallucination 12.64 9.88 7 202534 151 70725752
Injection site rash 12.63 9.88 17 202524 16393 70709510
Osteoarthritis 12.62 9.88 143 202398 74004 70651899
Pre-eclampsia 12.60 9.88 44 202497 6441 70719462
Alcohol poisoning 12.58 9.88 34 202507 4331 70721572
Renal aplasia 12.56 9.88 6 202535 94 70725809
Partner stress 12.55 9.88 9 202532 309 70725594
Limited symptom panic attack 12.55 9.88 5 202536 49 70725854
Colitis ulcerative 12.52 9.88 52 202489 33871 70692032
Ideas of reference 12.52 9.88 7 202534 154 70725749
Consciousness fluctuating 12.51 9.88 20 202521 1756 70724147
Inflammation 12.51 9.88 154 202387 78511 70647392
Accident at work 12.49 9.88 15 202526 1006 70724897
Unresponsive to stimuli 12.43 9.88 213 202328 51718 70674185
Post-traumatic stress disorder 12.38 9.88 34 202507 4373 70721530
Poor personal hygiene 12.37 9.88 11 202530 517 70725386
Exposure via transplant 12.34 9.88 4 202537 20 70725883
Rash maculo-papular 12.31 9.88 89 202452 50456 70675447
Patella fracture 12.24 9.88 19 202522 1627 70724276
Hypervolaemia 12.22 9.88 65 202476 39641 70686262
Aplasia pure red cell 12.21 9.88 3 202538 7371 70718532
Personality change 12.21 9.88 54 202487 8816 70717087
Pleural rub 12.20 9.88 5 202536 53 70725850
Multiple-drug resistance 12.17 9.88 3 202538 7352 70718551
Bladder cancer 12.15 9.88 19 202522 17223 70708680
Full blood count decreased 12.04 9.88 32 202509 23886 70702017
Deja vu 12.04 9.88 5 202536 55 70725848
Generalised anxiety disorder 12.02 9.88 21 202520 1984 70723919
Withdrawal catatonia 12.01 9.88 7 202534 167 70725736
Dropped head syndrome 11.99 9.88 8 202533 244 70725659
Agoraphobia 11.98 9.88 11 202530 539 70725364
Impulse-control disorder 11.96 9.88 19 202522 1660 70724243
Large intestine perforation 11.95 9.88 12 202529 13183 70712720
Ligament pain 11.85 9.88 8 202533 249 70725654
Tuberculosis 11.82 9.88 15 202526 14833 70711070
Dreamy state 11.80 9.88 5 202536 58 70725845
Blood immunoglobulin E increased 11.77 9.88 35 202506 4709 70721194
Anxiety disorder 11.75 9.88 31 202510 3894 70722009
Morbihan disease 11.73 9.88 4 202537 24 70725879
Hypokalaemia 11.71 9.88 285 202256 130903 70595000
Head injury 11.70 9.88 149 202392 33992 70691911
Enterocolitis 11.70 9.88 12 202529 13054 70712849
Radiation inflammation 11.68 9.88 11 202530 557 70725346
Allodynia 11.67 9.88 17 202524 1376 70724527
Feeling of body temperature change 11.66 9.88 36 202505 4943 70720960
Oesophagitis 11.64 9.88 30 202511 22622 70703281
Hepatic encephalopathy 11.59 9.88 29 202512 22089 70703814
Hypoxia 11.58 9.88 192 202349 93152 70632751
Cholestatic liver injury 11.55 9.88 32 202509 4136 70721767
Pseudomonas infection 11.51 9.88 23 202518 18971 70706932
Psychiatric decompensation 11.51 9.88 26 202515 2961 70722942
Osteomyelitis 11.49 9.88 46 202495 30272 70695631
Grandiosity 11.48 9.88 11 202530 569 70725334
Pain in jaw 11.45 9.88 73 202468 42596 70683307
Blood glucose increased 11.44 9.88 216 202325 102766 70623137
Urinary tract infection 11.43 9.88 587 201954 248182 70477721
Bladder dilatation 11.39 9.88 20 202521 1897 70724006
Pancreatic carcinoma 11.39 9.88 12 202529 12892 70713011
Facial nerve disorder 11.37 9.88 12 202529 698 70725205
Type 2 diabetes mellitus 11.36 9.88 183 202358 43897 70682006
Neuropsychiatric syndrome 11.33 9.88 6 202535 118 70725785
Magical thinking 11.31 9.88 3 202538 6 70725897
Creutzfeldt-Jakob disease 11.28 9.88 7 202534 188 70725715
Acidosis 11.26 9.88 90 202451 18173 70707730
Product formulation issue 11.24 9.88 13 202528 837 70725066
Therapy interrupted 11.16 9.88 35 202506 24767 70701136
Antiphospholipid antibodies 11.16 9.88 6 202535 122 70725781
Gun shot wound 11.14 9.88 15 202526 1128 70724775
Anuria 11.13 9.88 95 202446 19558 70706345
Central nervous system necrosis 11.12 9.88 8 202533 276 70725627
Premature delivery 11.11 9.88 28 202513 21276 70704627
Blood lactic acid increased 11.10 9.88 62 202479 11111 70714792
Infective pulmonary exacerbation of cystic fibrosis 11.08 9.88 11 202530 12147 70713756
Snoring 11.07 9.88 35 202506 4869 70721034
Squamous cell carcinoma of skin 11.02 9.88 12 202529 12700 70713203
Acute respiratory failure 11.00 9.88 99 202442 53566 70672337
Disorganised speech 10.97 9.88 19 202522 1782 70724121
Amenorrhoea 10.95 9.88 44 202497 6886 70719017
Intestinal anastomosis complication 10.87 9.88 8 202533 286 70725617
Platelet aggregation abnormal 10.86 9.88 4 202537 31 70725872
Colon cancer 10.83 9.88 15 202526 14291 70711612
Appendicectomy 10.78 9.88 22 202519 2336 70723567
Hyperphagia 10.78 9.88 22 202519 2337 70723566
Pseudohyponatraemia 10.77 9.88 6 202535 131 70725772
Pulmonary vein occlusion 10.77 9.88 6 202535 131 70725772
Tic 10.77 9.88 24 202517 2709 70723194
Mechanical urticaria 10.76 9.88 9 202532 389 70725514
Gonadotrophin deficiency 10.75 9.88 4 202537 32 70725871
Device issue 10.74 9.88 34 202507 23991 70701912
Accidental overdose 10.68 9.88 150 202391 34971 70690932
Slow speech 10.68 9.88 21 202520 2171 70723732
Coronary artery disease 10.67 9.88 121 202420 62615 70663288
Respiratory rate decreased 10.67 9.88 34 202507 4748 70721155
Alcohol withdrawal syndrome 10.67 9.88 19 202522 1822 70724081
Polyarthritis 10.67 9.88 9 202532 10747 70715156
Sleep talking 10.67 9.88 14 202527 1027 70724876
Stereotypy 10.67 9.88 13 202528 885 70725018
Norepinephrine increased 10.66 9.88 5 202536 75 70725828
Juvenile myoclonic epilepsy 10.66 9.88 5 202536 75 70725828
Knee arthroplasty 10.64 9.88 56 202485 34245 70691658
Skull fractured base 10.64 9.88 8 202533 296 70725607
Hyperemesis gravidarum 10.53 9.88 9 202532 401 70725502
Tanning 10.48 9.88 5 202536 78 70725825
Hypotonia neonatal 10.48 9.88 5 202536 78 70725825
Cystic lymphangioma 10.45 9.88 3 202538 9 70725894
Treatment noncompliance 10.42 9.88 189 202352 46385 70679518
Coagulation factor VII level decreased 10.39 9.88 7 202534 217 70725686
Marital problem 10.39 9.88 7 202534 217 70725686
Aortic stenosis 10.37 9.88 3 202538 6613 70719290
Coordination abnormal 10.36 9.88 80 202461 15986 70709917
Accidental exposure to product 10.36 9.88 43 202498 28008 70697895
Action tremor 10.32 9.88 9 202532 412 70725491
Skin disorder 10.32 9.88 48 202493 30309 70695594
Vascular device infection 10.32 9.88 5 202536 8025 70717878
Candida infection 10.30 9.88 57 202484 34416 70691487
Human chorionic gonadotropin positive 10.24 9.88 4 202537 37 70725866
Device leakage 10.24 9.88 7 202534 9301 70716602
Salivary gland disorder 10.23 9.88 8 202533 314 70725589
Constricted affect 10.21 9.88 3 202538 10 70725893
Rectal fissure 10.21 9.88 12 202529 786 70725117
Opiates positive 10.19 9.88 13 202528 927 70724976
Renal injury 10.18 9.88 19 202522 16075 70709828
Staring 10.17 9.88 22 202519 2434 70723469
Rib fracture 10.16 9.88 114 202427 25242 70700661
Right ventricular systolic pressure decreased 10.15 9.88 5 202536 84 70725819
Clumsiness 10.14 9.88 24 202517 2818 70723085
Anaphylactic shock 10.11 9.88 53 202488 32437 70693466
Disability 10.10 9.88 17 202524 14966 70710937
Blood triglycerides increased 10.08 9.88 93 202448 19571 70706332
Psychomotor skills impaired 10.06 9.88 31 202510 4253 70721650
Joint effusion 10.03 9.88 18 202523 15459 70710444
Chills 10.00 9.88 326 202215 144460 70581443
Large cell lung cancer metastatic 9.99 9.88 3 202538 11 70725892
Radius fracture 9.98 9.88 26 202515 3240 70722663
Ovarian cancer stage III 9.98 9.88 7 202534 232 70725671
Victim of crime 9.98 9.88 9 202532 431 70725472
Cartilage injury 9.97 9.88 16 202525 1410 70724493
Intellectual disability 9.97 9.88 14 202527 1096 70724807
Anorexia nervosa 9.93 9.88 7 202534 234 70725669
Atrioventricular block 9.91 9.88 13 202528 12675 70713228
Alpha 2 globulin increased 9.91 9.88 6 202535 154 70725749

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Selective eating disorder 42.74 25.54 91 2038 1137 86526
Premature baby 28.97 25.54 31 2098 3897 83766
Hypotonia neonatal 28.54 25.54 59 2070 717 86946
Mitral valve incompetence 27.87 25.54 12 2117 7 87656
Neonatal asphyxia 27.43 25.54 22 2107 89 87574

Pharmacologic Action:

SourceCodeDescription
ATC N06AX16 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D000068760 Serotonin and Noradrenaline Reuptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:51039 dopamine reuptake inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
FDA EPC N0000175749 Serotonin and Norepinephrine Reuptake Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Social phobia indication 25501002 DOID:11257
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Menopausal flushing off-label use 198436008
Neuropathic pain off-label use 247398009
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperthyroidism contraindication 34486009 DOID:7998
Upper gastrointestinal hemorrhage contraindication 37372002
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Mania contraindication 231494001
Hypomania contraindication 231496004
Interstitial lung disease contraindication 233703007 DOID:3082
Disease of liver contraindication 235856003 DOID:409
Hypertriglyceridemia contraindication 302870006
Serotonin syndrome contraindication 371089000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.05 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 5.98 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.65 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.70 PDSP
5-hydroxytryptamine receptor 6 GPCR Ki 5.55 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.44 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.05 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 7.60 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.44 CHEMBL
Transporter Transporter Ki 6.86 CHEMBL
Transporter Transporter IC50 6.19 CHEMBL

External reference:

IDSource
4023901 VUID
N0000021906 NUI
D00821 KEGG_DRUG
99300-78-4 SECONDARY_CAS_RN
4020846 VANDF
4023901 VANDF
C0078569 UMLSCUI
CHEBI:9943 CHEBI
CHEMBL637 ChEMBL_ID
DB00285 DRUGBANK_ID
CHEMBL1201066 ChEMBL_ID
D000069470 MESH_DESCRIPTOR_UI
5656 PUBCHEM_CID
7321 IUPHAR_LIGAND_ID
6358 INN_ID
GRZ5RCB1QG UNII
151692 RXNORM
5669 MMSL
594 MMSL
87651 MMSL
d03181 MMSL
004428 NDDF
004429 NDDF
108432009 SNOMEDCT_US
108434005 SNOMEDCT_US
372490001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0833 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0833 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0836 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0836 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0837 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 40 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0837 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 40 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7384 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7384 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7385 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7385 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7386 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7386 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9147 TABLET 25 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9147 TABLET 25 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9148 TABLET 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9148 TABLET 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9149 TABLET 50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9149 TABLET 50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9157 TABLET 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9157 TABLET 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9163 TABLET 100 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9163 TABLET 100 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2604 TABLET 150 mg ORAL ANDA 30 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2605 TABLET 225 mg ORAL ANDA 30 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0527-2606 TABLET 75 mg ORAL ANDA 29 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-6566 TABLET 37.50 mg ORAL ANDA 25 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-6567 TABLET 75 mg ORAL ANDA 23 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7557 TABLET 50 mg ORAL ANDA 23 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7558 TABLET 100 mg ORAL ANDA 23 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7621 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 32 sections