venlafaxine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2813 93413-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • venlafaxine
  • (+/-)-Venlafaxine
  • velafax
  • venlafaxin
  • venlafexine
  • venlafaxine hydrochloride
  • effexor
  • WY-45,030
  • venlafaxine HCl
A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
  • Molecular weight: 277.41
  • Formula: C17H27NO2
  • CLOGP: 3.27
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.70
  • ALOGS: -3.08
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 572 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.59 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 45 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 14 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.73 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1993 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 1115.59 9.65 849 159333 26535 46499345
Completed suicide 1115.40 9.65 1881 158301 144039 46381841
Intentional overdose 897.65 9.65 1110 159072 63834 46462046
Suicide attempt 762.54 9.65 942 159240 54094 46471786
Suicidal ideation 741.21 9.65 940 159242 55442 46470438
Serotonin syndrome 724.13 9.65 627 159555 23593 46502287
Toxicity to various agents 594.55 9.65 1834 158348 209932 46315948
Depression 567.31 9.65 1567 158615 168537 46357343
Intentional self-injury 451.56 9.65 483 159699 23683 46502197
Overdose 438.85 9.65 1035 159147 100944 46424936
Drug abuse 385.54 9.65 741 159441 62667 46463213
Withdrawal syndrome 364.73 9.65 377 159805 17757 46508123
Drug interaction 355.08 9.65 1508 158674 201586 46324294
Agitation 298.83 9.65 616 159566 54799 46471081
Rheumatoid arthritis 291.64 9.65 238 159944 239977 46285903
Anxiety 282.96 9.65 1305 158877 180652 46345228
Sopor 265.71 9.65 334 159848 19494 46506386
Tremor 238.01 9.65 904 159278 114735 46411145
Coma 234.42 9.65 577 159605 57772 46468108
Poisoning deliberate 222.37 9.65 198 159984 7728 46518152
Mydriasis 218.71 9.65 223 159959 10330 46515550
Crying 201.46 9.65 302 159880 20839 46505041
Hyperhidrosis 186.02 9.65 701 159481 88607 46437273
Electrocardiogram QT prolonged 176.70 9.65 479 159703 50846 46475034
Akathisia 174.58 9.65 171 160011 7543 46518337
Joint swelling 160.84 9.65 200 159982 165873 46360007
Depressed mood 159.50 9.65 353 159829 32966 46492914
Seizure 155.11 9.65 832 159350 122222 46403658
Somnolence 154.44 9.65 992 159190 155529 46370351
Disturbance in attention 151.79 9.65 335 159847 31225 46494655
Panic attack 141.05 9.65 251 159931 19991 46505889
Irritability 140.05 9.65 308 159874 28638 46497242
Contraindicated product administered 135.98 9.65 52 160130 79895 46445985
Pneumonia 135.22 9.65 749 159433 375571 46150309
Nightmare 133.01 9.65 219 159963 16379 46509501
Anger 131.48 9.65 182 160000 11670 46514210
Anaemia 130.98 9.65 445 159737 255334 46270546
Restlessness 127.36 9.65 275 159907 25249 46500631
Aggression 123.90 9.65 254 159928 22490 46503390
Treatment failure 123.37 9.65 84 160098 93003 46432877
Febrile neutropenia 123.28 9.65 87 160095 94540 46431340
Rash 121.89 9.65 721 159461 355791 46170089
Cardiac arrest 117.12 9.65 616 159566 89783 46436097
Off label use 116.61 9.65 794 159388 379047 46146833
Feeling abnormal 114.43 9.65 778 159404 124282 46401598
Respiratory arrest 113.77 9.65 313 159869 33503 46492377
Drug dependence 106.93 9.65 221 159961 19680 46506200
Product substitution issue 106.80 9.65 188 159994 14843 46511037
Confusional state 106.76 9.65 924 159258 158968 46366912
Synovitis 106.76 9.65 38 160144 61037 46464843
Systemic lupus erythematosus 106.58 9.65 45 160137 65135 46460745
Sepsis 105.28 9.65 191 159991 135823 46390057
Poisoning 104.61 9.65 179 160003 13815 46512065
Disorientation 102.42 9.65 319 159863 36599 46489281
Generalised tonic-clonic seizure 100.29 9.65 260 159922 26862 46499018
Insomnia 98.83 9.65 931 159251 163993 46361887
Pyrexia 96.91 9.65 750 159432 348052 46177828
Psychomotor hyperactivity 96.86 9.65 141 160041 9472 46516408
Major depression 94.91 9.65 116 160066 6574 46519306
Tearfulness 92.33 9.65 91 160091 4044 46521836
Diarrhoea 91.66 9.65 1361 158821 558241 45967639
Selective eating disorder 91.27 9.65 63 160119 1682 46524198
Dyspnoea 91.07 9.65 1235 158947 514313 46011567
Weight increased 89.52 9.65 910 159272 163563 46362317
Mania 89.46 9.65 145 160037 10701 46515179
Gestational diabetes 89.45 9.65 117 160065 7102 46518778
Platelet count decreased 89.09 9.65 128 160054 99896 46425984
Sleep-related eating disorder 88.47 9.65 43 160139 576 46525304
Antidepressant drug level increased 88.34 9.65 34 160148 245 46525635
Tachycardia 88.28 9.65 615 159567 99007 46426873
Death 87.44 9.65 734 159448 334814 46191066
Drug withdrawal syndrome neonatal 85.61 9.65 63 160119 1865 46524015
Infection 85.42 9.65 209 159973 133383 46392497
Alopecia 82.06 9.65 284 159898 162130 46363750
Arthropathy 81.93 9.65 102 160080 84598 46441282
Infusion related reaction 80.21 9.65 140 160042 101068 46424812
Mood swings 79.81 9.65 174 160008 16078 46509802
Abnormal dreams 77.52 9.65 132 160050 10147 46515733
Hand deformity 76.92 9.65 13 160169 34561 46491319
Amnesia 75.48 9.65 313 159869 41318 46484562
Muscle rigidity 75.23 9.65 128 160054 9833 46516047
Thrombocytopenia 74.07 9.65 207 159975 126374 46399506
Small for dates baby 73.80 9.65 76 160106 3561 46522319
Neutropenia 73.28 9.65 249 159933 142955 46382925
Paraesthesia 71.83 9.65 666 159516 116771 46409109
Self-injurious ideation 71.65 9.65 61 160121 2239 46523641
Cardio-respiratory arrest 70.78 9.65 398 159784 59471 46466409
Hypersensitivity 70.55 9.65 271 159911 150050 46375830
Thinking abnormal 70.05 9.65 123 160059 9691 46516189
Renal impairment 69.40 9.65 92 160090 74280 46451600
Hyperreflexia 67.98 9.65 87 160095 5167 46520713
Sedation 67.31 9.65 202 159980 22708 46503172
Decorticate posture 66.94 9.65 30 160152 330 46525550
Homicide 66.82 9.65 32 160150 414 46525466
Psychomotor retardation 66.40 9.65 68 160114 3165 46522715
Arthralgia 65.82 9.65 869 159313 363734 46162146
Myocardial depression 65.80 9.65 33 160149 475 46525405
Galactorrhoea 64.13 9.65 72 160110 3725 46522155
Atrial fibrillation 63.92 9.65 165 160017 103425 46422455
Hallucination 63.70 9.65 339 159843 49612 46476268
Antidepressant drug level above therapeutic 63.38 9.65 29 160153 336 46525544
Haemoglobin decreased 62.76 9.65 229 159953 128720 46397160
Disease progression 62.22 9.65 138 160044 91162 46434718
Apathy 61.08 9.65 98 160084 7170 46518710
Abdominal discomfort 60.81 9.65 289 159893 150876 46375004
C-reactive protein abnormal 60.42 9.65 3 160179 21267 46504613
Neuroleptic malignant syndrome 60.32 9.65 124 160058 10998 46514882
Tardive dyskinesia 59.72 9.65 99 160083 7444 46518436
Mental disorder 59.65 9.65 191 159991 22234 46503646
Mental impairment 59.62 9.65 132 160050 12324 46513556
Abnormal behaviour 59.36 9.65 183 159999 20875 46505005
Physical assault 59.09 9.65 39 160143 965 46524915
Malignant neoplasm progression 58.88 9.65 82 160100 64844 46461036
Hypotonia neonatal 58.74 9.65 37 160145 843 46525037
Pancytopenia 58.43 9.65 128 160054 84930 46440950
Large for dates baby 56.82 9.65 29 160153 434 46525446
Meconium in amniotic fluid 56.64 9.65 22 160160 163 46525717
Atrial septal defect 55.45 9.65 87 160095 6245 46519635
Pain 55.21 9.65 1232 158950 475716 46050164
Plasma cell myeloma 55.18 9.65 43 160139 44435 46481445
Acute kidney injury 55.18 9.65 530 159652 235325 46290555
Drug screen false positive 53.89 9.65 35 160147 842 46525038
Peripheral swelling 53.68 9.65 320 159862 157751 46368129
Glossodynia 53.67 9.65 44 160138 44329 46481551
Intentional product misuse 53.53 9.65 310 159872 46818 46479062
Depressive symptom 53.50 9.65 57 160125 2779 46523101
Foetal exposure during pregnancy 53.26 9.65 228 159954 30519 46495361
Swelling 53.07 9.65 233 159949 124278 46401602
Cough 52.76 9.65 520 159662 229729 46296151
Bipolar disorder 52.59 9.65 91 160091 7086 46518794
Homicidal ideation 52.50 9.65 46 160136 1756 46524124
Extrapyramidal disorder 52.35 9.65 118 160064 11150 46514730
Stress cardiomyopathy 52.27 9.65 95 160087 7689 46518191
Nervousness 51.54 9.65 214 159968 28261 46497619
Gastrointestinal haemorrhage 51.05 9.65 119 160063 77254 46448626
Anaphylactic reaction 50.27 9.65 65 160117 53047 46472833
Neonatal hypoxia 50.06 9.65 27 160155 455 46525425
Psychotic disorder 49.91 9.65 181 160001 22440 46503440
Product residue present 49.79 9.65 64 160118 3818 46522062
Drug intolerance 49.23 9.65 299 159883 146750 46379130
Benzodiazepine drug level increased 49.13 9.65 20 160162 170 46525710
Impulsive behaviour 48.88 9.65 41 160141 1474 46524406
Tinnitus 48.54 9.65 206 159976 27467 46498413
Feeling of despair 48.47 9.65 44 160138 1761 46524119
Herpes zoster 48.40 9.65 100 160082 67772 46458108
Nasopharyngitis 47.53 9.65 321 159861 153677 46372203
Cataplexy 47.18 9.65 36 160146 1127 46524753
Dizziness 46.43 9.65 1511 158671 338903 46186977
Opsoclonus myoclonus 46.38 9.65 18 160164 133 46525747
Suicidal behaviour 45.83 9.65 49 160133 2399 46523481
Fluid retention 45.75 9.65 65 160117 50981 46474899
Bruxism 45.56 9.65 54 160128 2963 46522917
Nystagmus 45.39 9.65 75 160107 5624 46520256
Parkinsonism 44.74 9.65 90 160092 7858 46518022
Muscle twitching 44.65 9.65 131 160051 14541 46511339
Pleural effusion 44.64 9.65 141 160041 82811 46443069
Mood altered 44.34 9.65 121 160061 12886 46512994
Personality disorder 43.92 9.65 54 160128 3079 46522801
Somnambulism 43.82 9.65 69 160113 4968 46520912
Hypomania 43.68 9.65 64 160118 4324 46521556
Myoclonus 43.54 9.65 128 160054 14224 46511656
Pain in extremity 43.22 9.65 626 159556 258054 46267826
White blood cell count decreased 43.13 9.65 218 159964 112013 46413867
Altered state of consciousness 42.67 9.65 176 160006 23172 46502708
Drug hypersensitivity 42.15 9.65 1115 159067 242710 46283170
Self esteem decreased 41.82 9.65 25 160157 517 46525363
Hallucination, auditory 41.71 9.65 105 160077 10651 46515229
Pericarditis 41.61 9.65 15 160167 23912 46501968
Panic reaction 41.44 9.65 57 160125 3632 46522248
Bezoar 40.90 9.65 36 160146 1383 46524497
Leukopenia 40.52 9.65 111 160071 68232 46457648
Hallucination, visual 40.27 9.65 144 160038 17729 46508151
Injection site pain 40.12 9.65 210 159972 106942 46418938
Foetal death 40.00 9.65 91 160091 8652 46517228
Respiratory depression 39.63 9.65 108 160074 11492 46514388
Vertigo 39.61 9.65 310 159872 51738 46474142
Anorgasmia 39.56 9.65 25 160157 573 46525307
Dissociation 39.50 9.65 40 160142 1837 46524043
Neutrophil count decreased 39.21 9.65 55 160127 43371 46482509
Erythema 39.11 9.65 308 159874 142512 46383368
Memory impairment 38.75 9.65 421 159761 76916 46448964
Toxic epidermal necrolysis 38.69 9.65 14 160168 22264 46503616
Mucosal inflammation 38.66 9.65 46 160136 38930 46486950
Transient tachypnoea of the newborn 38.63 9.65 15 160167 111 46525769
Paranoia 38.56 9.65 101 160081 10496 46515384
Libido decreased 38.31 9.65 46 160136 2559 46523321
Inappropriate affect 38.25 9.65 28 160154 822 46525058
Euphoric mood 37.83 9.65 59 160123 4213 46521667
Restless legs syndrome 37.73 9.65 130 160052 15713 46510167
Bone marrow failure 37.67 9.65 28 160154 29641 46496239
Emotional disorder 37.47 9.65 110 160072 12214 46513666
Renal papillary necrosis 37.31 9.65 18 160164 237 46525643
Hypothermia 37.29 9.65 109 160073 12074 46513806
Anticholinergic syndrome 37.12 9.65 38 160144 1768 46524112
Migraine 36.86 9.65 385 159797 69641 46456239
Hot flush 36.39 9.65 265 159917 43252 46482628
Electrocardiogram QRS complex prolonged 35.95 9.65 66 160116 5383 46520497
Amniorrhexis 35.87 9.65 10 160172 20 46525860
Agitation neonatal 35.64 9.65 22 160160 483 46525397
Hospitalisation 35.34 9.65 106 160076 63279 46462601
Lung disorder 35.11 9.65 59 160123 43245 46482635
Blood creatinine increased 35.01 9.65 139 160043 76264 46449616
Injection site erythema 35.00 9.65 134 160048 74293 46451587
Rapid eye movement sleep behaviour disorder 34.72 9.65 15 160167 150 46525730
Congenital hearing disorder 34.52 9.65 9 160173 12 46525868
Psychotic symptom 34.37 9.65 27 160155 883 46524997
Bradycardia neonatal 33.88 9.65 23 160159 597 46525283
Total lung capacity increased 33.71 9.65 25 160157 749 46525131
Mobility decreased 33.30 9.65 102 160080 60492 46465388
Loss of consciousness 32.87 9.65 538 159644 107700 46418180
Hypersomnia 32.77 9.65 122 160060 15317 46510563
Adjustment disorder with mixed anxiety and depressed mood 32.76 9.65 12 160170 74 46525806
VACTERL syndrome 32.62 9.65 9 160173 17 46525863
Hostility 32.33 9.65 31 160151 1331 46524549
Negative thoughts 32.29 9.65 25 160157 800 46525080
Brain death 32.29 9.65 44 160138 2779 46523101
Coma scale abnormal 32.23 9.65 60 160122 4946 46520934
Emotional poverty 32.19 9.65 17 160165 274 46525606
Social avoidant behaviour 32.09 9.65 44 160138 2795 46523085
Stomatitis 32.09 9.65 123 160059 68174 46457706
Urinary incontinence 31.96 9.65 187 159995 28343 46497537
Accommodation disorder 31.70 9.65 18 160164 337 46525543
Urinary tract infection 31.42 9.65 549 159633 219717 46306163
Neonatal respiratory distress syndrome 31.30 9.65 41 160141 2492 46523388
Neuropathy peripheral 30.83 9.65 184 159998 90709 46435171
Loss of libido 30.70 9.65 30 160152 1319 46524561
Ascites 30.45 9.65 49 160133 36535 46489345
Oedema 30.11 9.65 123 160059 66948 46458932
Rhinorrhoea 30.10 9.65 75 160107 47590 46478290
Respiratory failure 29.55 9.65 197 159985 94619 46431261
Hyperprolactinaemia 29.53 9.65 43 160139 2889 46522991
Bipolar II disorder 29.49 9.65 16 160166 273 46525607
Delusion 29.48 9.65 95 160087 11093 46514787
Dyskinesia 29.48 9.65 185 159997 28740 46497140
Panic disorder 29.42 9.65 40 160142 2521 46523359
Product use issue 29.32 9.65 197 159985 94447 46431433
Burnout syndrome 29.11 9.65 14 160168 183 46525697
Vitamin K decreased 29.03 9.65 8 160174 15 46525865
Logorrhoea 28.86 9.65 38 160144 2321 46523559
Haemangioma congenital 28.76 9.65 19 160163 471 46525409
Derealisation 28.56 9.65 23 160159 780 46525100
Oropharyngeal pain 28.52 9.65 144 160038 74024 46451856
Asphyxia 28.43 9.65 59 160123 5267 46520613
Sinus tachycardia 28.33 9.65 148 160034 21501 46504379
Endolymphatic hydrops 28.07 9.65 6 160176 0 46525880
Drug screen positive 28.07 9.65 49 160133 3842 46522038
Sinusitis 28.06 9.65 297 159885 129471 46396409
Knee arthroplasty 27.96 9.65 24 160158 23641 46502239
Neonatal behavioural syndrome 27.94 9.65 9 160173 35 46525845
Prescribed overdose 27.78 9.65 89 160093 10360 46515520
Parkinsonism hyperpyrexia syndrome 27.72 9.65 13 160169 160 46525720
Camptocormia 27.70 9.65 14 160168 205 46525675
General physical health deterioration 27.51 9.65 259 159923 115510 46410370
Foetal alcohol syndrome 27.47 9.65 8 160174 20 46525860
Cytomegalovirus infection 27.37 9.65 14 160168 18130 46507750
Wound 27.30 9.65 67 160115 42735 46483145
Exposure during pregnancy 27.20 9.65 522 159660 107690 46418190
Cardiac failure 27.03 9.65 162 160020 79786 46446094
Upper respiratory tract infection 27.02 9.65 119 160063 63437 46462443
Congenital absence of bile ducts 26.99 9.65 9 160173 40 46525840
Feeling jittery 26.80 9.65 91 160091 10917 46514963
Affect lability 26.73 9.65 74 160108 7946 46517934
C-reactive protein increased 26.58 9.65 107 160075 58483 46467397
Abulia 26.51 9.65 16 160166 337 46525543
Psoriatic arthropathy 26.44 9.65 53 160129 36326 46489554
Sleep disorder 26.40 9.65 261 159921 46534 46479346
Back pain 26.39 9.65 535 159647 209504 46316376
Delirium 26.29 9.65 218 159964 37010 46488870
Renal failure 26.20 9.65 256 159926 113338 46412542
Tachyphrenia 26.18 9.65 27 160155 1267 46524613
Cardiac failure congestive 25.97 9.65 196 159986 91554 46434326
Femur fracture 25.95 9.65 55 160127 36942 46488938
Diverticulitis 25.89 9.65 46 160136 32993 46492887
Musculoskeletal stiffness 25.58 9.65 214 159968 97779 46428101
Septic shock 25.47 9.65 107 160075 57786 46468094
Antipsychotic drug level increased 25.41 9.65 42 160140 3150 46522730
Disturbance in sexual arousal 25.19 9.65 10 160172 79 46525801
Hepatic function abnormal 25.14 9.65 50 160132 34371 46491509
Red blood cell sedimentation rate increased 24.93 9.65 25 160157 22864 46503016
Pleurothotonus 24.83 9.65 25 160157 1140 46524740
Encephalopathy neonatal 24.78 9.65 7 160175 15 46525865
Pyramidal tract syndrome 24.72 9.65 15 160167 319 46525561
Helplessness 24.70 9.65 13 160169 208 46525672
Hyperkalaemia 24.68 9.65 90 160092 50619 46475261
Cold sweat 24.50 9.65 88 160094 10857 46515023
Hip arthroplasty 24.44 9.65 16 160166 18096 46507784
Frustration tolerance decreased 24.36 9.65 55 160127 5202 46520678
Psychiatric symptom 24.22 9.65 50 160132 4447 46521433
Hypocalcaemia 24.10 9.65 34 160148 26751 46499129
Drug level increased 24.08 9.65 126 160056 18315 46507565
Cerebral infarction 23.79 9.65 27 160155 23339 46502541
Epilepsy 23.68 9.65 151 160031 23587 46502293
Impaired work ability 23.68 9.65 96 160086 12540 46513340
Tic 23.60 9.65 25 160157 1211 46524669
Productive cough 23.40 9.65 92 160090 50623 46475257
Unemployment 23.39 9.65 5 160177 0 46525880
Peritonitis 23.28 9.65 22 160160 20692 46505188
Electrocardiogram ST-T segment abnormal 22.96 9.65 13 160169 242 46525638
Depressed level of consciousness 22.93 9.65 257 159925 47312 46478568
Deja vu 22.87 9.65 7 160175 22 46525858
Device expulsion 22.82 9.65 37 160145 27505 46498375
Impaired driving ability 22.79 9.65 47 160135 4177 46521703
Obsessive thoughts 22.79 9.65 17 160165 514 46525366
Hyperacusis 22.77 9.65 30 160152 1834 46524046
Congenital pulmonary hypertension 22.69 9.65 9 160173 71 46525809
Acquired amegakaryocytic thrombocytopenia 22.60 9.65 6 160176 9 46525871
Eosinophilic pustular folliculitis 22.41 9.65 7 160175 24 46525856
Asthenia 22.15 9.65 858 159324 310217 46215663
Drug ineffective 22.05 9.65 2015 158167 675823 45850057
Speech disorder 22.02 9.65 205 159977 35962 46489918
Discomfort 21.95 9.65 84 160098 46586 46479294
Ventricular septal defect 21.90 9.65 45 160137 3989 46521891
Antisocial behaviour 21.90 9.65 12 160170 209 46525671
Respiratory disorder neonatal 21.80 9.65 21 160161 907 46524973
Therapeutic product effect decreased 21.73 9.65 180 160002 82421 46443459
Abnormal weight gain 21.57 9.65 26 160156 1452 46524428
Dystonia 21.47 9.65 86 160096 11171 46514709
Central nervous system necrosis 21.40 9.65 10 160172 122 46525758
Blood catecholamines increased 21.39 9.65 7 160175 29 46525851
Coma acidotic 21.26 9.65 10 160172 124 46525756
Oedema peripheral 21.20 9.65 403 159779 159303 46366577
Platelet aggregation abnormal 21.05 9.65 5 160177 3 46525877
Helicobacter infection 21.02 9.65 7 160175 11729 46514151
Erythema dyschromicum perstans 20.98 9.65 8 160174 56 46525824
Cognitive disorder 20.94 9.65 206 159976 36677 46489203
Patent ductus arteriosus 20.87 9.65 43 160139 3819 46522061
Type 2 diabetes mellitus 20.81 9.65 128 160054 19747 46506133
Cardiogenic shock 20.74 9.65 111 160071 16273 46509607
Neonatal seizure 20.42 9.65 13 160169 302 46525578
Pulmonary arterial hypertension 20.40 9.65 36 160146 25892 46499988
Drug eruption 20.28 9.65 26 160156 21303 46504577
Persistent depressive disorder 20.27 9.65 21 160161 991 46524889
Social anxiety disorder 20.24 9.65 14 160168 375 46525505
Torsade de pointes 20.18 9.65 89 160093 12065 46513815
Neonatal tachypnoea 20.18 9.65 8 160174 63 46525817
Dyssomnia 20.17 9.65 7 160175 36 46525844
Trunk injury 20.07 9.65 6 160176 17 46525863
Bone erosion 20.04 9.65 4 160178 9439 46516441
Cellulitis 19.96 9.65 150 160032 70138 46455742
Starvation ketoacidosis 19.86 9.65 8 160174 66 46525814
Peritonitis bacterial 19.82 9.65 3 160179 8650 46517230
Upper gastrointestinal haemorrhage 19.74 9.65 17 160165 16721 46509159
Yawning 19.68 9.65 19 160163 823 46525057
Enuresis 19.66 9.65 29 160153 1971 46523909
Arthritis 19.66 9.65 170 160012 77146 46448734
Neonatal disorder 19.60 9.65 17 160165 640 46525240
Right ventricular failure 19.40 9.65 16 160166 16077 46509803
Violence-related symptom 19.36 9.65 14 160168 403 46525477
Skin maceration 19.27 9.65 7 160175 42 46525838
Product dose omission issue 19.19 9.65 436 159746 168084 46357796
Drug use disorder 19.16 9.65 34 160148 2701 46523179
Persistent left superior vena cava 19.13 9.65 7 160175 43 46525837
Hyperbilirubinaemia neonatal 19.10 9.65 13 160169 339 46525541
Dysphoria 19.07 9.65 46 160136 4543 46521337
Bradypnoea 19.04 9.65 36 160146 3003 46522877
Dependence 18.98 9.65 28 160154 1903 46523977
Congenital tricuspid valve incompetence 18.97 9.65 8 160174 75 46525805
Vasoplegia syndrome 18.94 9.65 21 160161 1071 46524809
Congenital uterine anomaly 18.89 9.65 9 160173 115 46525765
Epistaxis 18.85 9.65 136 160046 64169 46461711
Transfusion 18.81 9.65 11 160171 13220 46512660
Rheumatoid nodule 18.77 9.65 4 160178 9016 46516864
Atypical fibroxanthoma 18.71 9.65 4 160178 0 46525880
Distributive shock 18.70 9.65 15 160167 506 46525374
Pneumonia aspiration 18.67 9.65 178 160004 31427 46494453
CYP3A4 polymorphism 18.52 9.65 8 160174 80 46525800
Therapeutic product effect incomplete 18.49 9.65 175 160007 77978 46447902
Palmar-plantar erythrodysaesthesia syndrome 18.36 9.65 26 160156 20425 46505455
Floppy infant 18.35 9.65 8 160174 82 46525798
Tongue biting 18.30 9.65 23 160159 1341 46524539
Hypotonia 18.28 9.65 66 160116 8163 46517717
Abdominal pain 18.27 9.65 626 159556 229405 46296475
Osteonecrosis of jaw 18.13 9.65 59 160123 34343 46491537
Intestinal strangulation 17.85 9.65 8 160174 88 46525792
Tension 17.80 9.65 34 160148 2858 46523022
Metabolic syndrome 17.79 9.65 22 160160 1262 46524618
Hypnopompic hallucination 17.76 9.65 6 160176 28 46525852
Thrombosis 17.71 9.65 116 160066 55953 46469927
Bundle branch block right 17.61 9.65 46 160136 4773 46521107
Merycism 17.56 9.65 9 160173 136 46525744
Skin necrosis 17.53 9.65 4 160178 8600 46517280
Acute myeloid leukaemia 17.45 9.65 17 160165 15761 46510119
Encephalopathy 17.35 9.65 184 159998 33405 46492475
Feeling guilty 17.28 9.65 14 160168 479 46525401
Libido increased 17.25 9.65 17 160165 755 46525125
Bacteraemia 17.22 9.65 14 160168 14165 46511715
No adverse event 17.16 9.65 60 160122 34171 46491709
Schizophreniform disorder 17.14 9.65 7 160175 60 46525820
Tonic convulsion 17.04 9.65 20 160162 1086 46524794
Fluid overload 16.99 9.65 43 160139 27142 46498738
Flight of ideas 16.89 9.65 12 160170 336 46525544
Interstitial lung disease 16.85 9.65 112 160070 53837 46472043
Psychiatric decompensation 16.79 9.65 20 160162 1103 46524777
Eye movement disorder 16.75 9.65 45 160137 4748 46521132
Tremor neonatal 16.67 9.65 8 160174 104 46525776
Attention deficit hyperactivity disorder 16.52 9.65 28 160154 2144 46523736
Bronchitis 16.44 9.65 260 159922 105719 46420161
Cataract 16.43 9.65 90 160092 45325 46480555
Sluggishness 16.35 9.65 44 160138 4647 46521233
Drug abuser 16.31 9.65 35 160147 3198 46522682
Language disorder 16.31 9.65 23 160159 1500 46524380
COVID-19 16.30 9.65 24 160158 18551 46507329
Post-traumatic stress disorder 16.20 9.65 40 160142 4008 46521872
Respiratory tract inflammation 16.12 9.65 13 160169 442 46525438
Transient psychosis 16.11 9.65 6 160176 39 46525841
Wheezing 16.09 9.65 112 160070 53274 46472606
Feelings of worthlessness 16.09 9.65 11 160171 289 46525591
Bipolar I disorder 16.05 9.65 23 160159 1523 46524357
Dysarthria 16.03 9.65 198 159984 37300 46488580
Executive dysfunction 16.02 9.65 8 160174 114 46525766
Electroencephalogram abnormal 15.99 9.65 38 160144 3716 46522164
Anal atresia 15.97 9.65 12 160170 367 46525513
Nodule 15.92 9.65 18 160164 15587 46510293
Coarctation of the aorta 15.92 9.65 14 160168 537 46525343
Chronic kidney disease 15.91 9.65 79 160103 40792 46485088
Female sexual dysfunction 15.86 9.65 6 160176 41 46525839
Marchiafava-Bignami disease 15.82 9.65 5 160177 18 46525862
False positive investigation result 15.81 9.65 14 160168 542 46525338
Neurological examination abnormal 15.79 9.65 10 160172 230 46525650
Splenic infarction 15.75 9.65 23 160159 1549 46524331
Rhabdomyolysis 15.70 9.65 216 159966 41693 46484187
Affective disorder 15.63 9.65 44 160138 4771 46521109
Congestive cardiomyopathy 15.50 9.65 49 160133 5664 46520216
Facial nerve disorder 15.49 9.65 14 160168 557 46525323
Tumour lysis syndrome 15.49 9.65 3 160179 7233 46518647
Consciousness fluctuating 15.41 9.65 14 160168 561 46525319
Respiratory tract infection 15.39 9.65 52 160130 29920 46495960
Alcohol interaction 15.36 9.65 29 160153 2416 46523464
Infantile apnoea 15.36 9.65 16 160166 760 46525120
Acute myocardial infarction 15.31 9.65 57 160125 31867 46494013
Sciatic nerve neuropathy 15.26 9.65 11 160171 315 46525565
Subendocardial ischaemia 15.23 9.65 7 160175 82 46525798
Cogwheel rigidity 15.22 9.65 22 160160 1468 46524412
Postmortem blood drug level abnormal 15.20 9.65 11 160171 317 46525563
Neutropenic sepsis 15.17 9.65 12 160170 12312 46513568
Blood urea increased 15.15 9.65 41 160141 25311 46500569
Transplant rejection 15.09 9.65 7 160175 9589 46516291
Melaena 15.08 9.65 47 160135 27725 46498155
Cytopenia 15.07 9.65 4 160178 7764 46518116
Anticonvulsant drug level above therapeutic 15.07 9.65 13 160169 486 46525394
Device related infection 14.99 9.65 31 160151 21010 46504870
Forced expiratory volume decreased 14.98 9.65 45 160137 5059 46520821
Clonus 14.96 9.65 39 160143 4041 46521839
Throat irritation 14.93 9.65 50 160132 28851 46497029
Inappropriate antidiuretic hormone secretion 14.87 9.65 91 160091 14011 46511869
Hyponatraemia 14.85 9.65 454 159728 100878 46425002
Poor personal hygiene 14.85 9.65 11 160171 329 46525551
Thrombotic microangiopathy 14.80 9.65 5 160177 8301 46517579
Depression suicidal 14.77 9.65 22 160160 1508 46524372
Immunodeficiency 14.63 9.65 14 160168 13092 46512788
Pruritus 14.60 9.65 681 159501 241671 46284209
Neoplasm progression 14.60 9.65 45 160137 26638 46499242
Poverty of speech 14.58 9.65 10 160172 264 46525616
Ventricular tachycardia 14.57 9.65 104 160078 16863 46509017
Blood bilirubin increased 14.53 9.65 64 160118 34120 46491760
Right ventricular systolic pressure decreased 14.52 9.65 5 160177 25 46525855
Dry mouth 14.50 9.65 267 159915 54659 46471221
Nasal congestion 14.47 9.65 101 160081 48012 46477868
Persecutory delusion 14.46 9.65 29 160153 2526 46523354
Labour complication 14.45 9.65 7 160175 93 46525787
Coordination abnormal 14.42 9.65 75 160107 10874 46515006
Injection site bruising 14.38 9.65 68 160114 35568 46490312
Febrile bone marrow aplasia 14.36 9.65 3 160179 6859 46519021
Cystic lymphangioma 14.36 9.65 5 160177 26 46525854
Phagophobia 14.36 9.65 5 160177 26 46525854
Hypokalaemia 14.32 9.65 214 159968 87810 46438070
Injection site rash 14.30 9.65 20 160162 15793 46510087
Nonspecific reaction 14.27 9.65 24 160158 1826 46524054
Oxygen saturation decreased 14.26 9.65 160 160022 69004 46456876
Peak expiratory flow rate decreased 14.22 9.65 14 160168 621 46525259
Alcohol use 14.16 9.65 28 160154 2414 46523466
Epstein-Barr virus infection 14.13 9.65 3 160179 6781 46519099
Parachute mitral valve 14.13 9.65 7 160175 98 46525782
Feeling drunk 14.09 9.65 37 160145 3850 46522030
CYP2D6 polymorphism 14.04 9.65 3 160179 0 46525880
Corneal cyst 14.04 9.65 3 160179 0 46525880
Muscle tone disorder 14.00 9.65 7 160175 100 46525780
Skin discolouration 14.00 9.65 61 160121 32619 46493261
Metastases to bone 13.99 9.65 24 160158 17452 46508428
Lung diffusion test decreased 13.99 9.65 14 160168 634 46525246
Infective pulmonary exacerbation of cystic fibrosis 13.98 9.65 10 160172 10797 46515083
Proteinuria 13.93 9.65 22 160160 16531 46509349
Tympanic membrane disorder 13.89 9.65 8 160174 154 46525726
Iodine allergy 13.86 9.65 13 160169 543 46525337
Perinatal depression 13.82 9.65 13 160169 545 46525335
Impaired healing 13.75 9.65 72 160110 36671 46489209
Divorced 13.74 9.65 4 160178 10 46525870
Slow speech 13.73 9.65 20 160162 1344 46524536
Electrocardiogram QRS complex shortened 13.71 9.65 11 160171 371 46525509
Foetal arrhythmia 13.71 9.65 8 160174 158 46525722
Neonatal asphyxia 13.70 9.65 9 160173 221 46525659
Somatic symptom disorder 13.69 9.65 24 160158 1888 46523992
Rhythm idioventricular 13.66 9.65 8 160174 159 46525721
Pre-eclampsia 13.62 9.65 59 160123 7935 46517945
Mechanical urticaria 13.61 9.65 11 160171 375 46525505
Liver function test increased 13.58 9.65 37 160145 22789 46503091
Dialysis 13.56 9.65 9 160173 10107 46515773
Alcoholism 13.56 9.65 26 160156 2192 46523688
Death neonatal 13.55 9.65 9 160173 225 46525655
Pulmonary artery stenosis congenital 13.55 9.65 9 160173 225 46525655
Haematocrit decreased 13.51 9.65 68 160114 34989 46490891
Renal injury 13.47 9.65 8 160174 9533 46516347
Cholestatic liver injury 13.39 9.65 25 160157 2065 46523815
Hypercalcaemia 13.37 9.65 33 160149 21013 46504867
Cold agglutinins positive 13.36 9.65 5 160177 33 46525847
Cardiotoxicity 13.34 9.65 52 160130 6670 46519210
Drug level above therapeutic 13.34 9.65 34 160148 3475 46522405
Sexual dysfunction 13.28 9.65 27 160155 2376 46523504
Hypertonia neonatal 13.25 9.65 9 160173 234 46525646
Ligament pain 13.19 9.65 8 160174 170 46525710
Movement disorder 13.17 9.65 101 160081 16748 46509132
Dropped head syndrome 13.14 9.65 7 160175 115 46525765
Basal cell carcinoma 13.12 9.65 32 160150 20455 46505425
Myelosuppression 13.11 9.65 5 160177 7698 46518182
Asthma 13.08 9.65 228 159954 91314 46434566
Conversion disorder 13.06 9.65 22 160160 1676 46524204
Acute hepatitis B 13.05 9.65 10 160172 315 46525565
Dyspnoea exertional 13.04 9.65 110 160072 50179 46475701
Marital problem 13.03 9.65 8 160174 174 46525706
Blood creatine phosphokinase increased 13 9.65 149 160033 27575 46498305
Colitis 12.98 9.65 75 160107 37272 46488608
Feeling of body temperature change 12.97 9.65 38 160144 4214 46521666
Palpitations 12.96 9.65 423 159759 94836 46431044
Premature delivery 12.96 9.65 36 160146 22033 46503847
Device issue 12.96 9.65 31 160151 19949 46505931
Spine malformation 12.95 9.65 9 160173 243 46525637
Loose tooth 12.93 9.65 32 160150 3212 46522668
Adverse drug reaction 12.92 9.65 94 160088 44268 46481612
Chest discomfort 12.84 9.65 225 159957 90044 46435836
Pneumonitis 12.82 9.65 52 160130 28368 46497512
Nervous system disorder 12.78 9.65 97 160085 16032 46509848
Barotrauma 12.67 9.65 8 160174 183 46525697
Pulmonary hypertension 12.66 9.65 72 160110 35921 46489959
Musculoskeletal pain 12.64 9.65 167 160015 69961 46455919
Tuberculosis 12.63 9.65 10 160172 10255 46515625
Apallic syndrome 12.61 9.65 13 160169 610 46525270
Tenosynovitis 12.58 9.65 5 160177 7510 46518370
Complication associated with device 12.55 9.65 21 160161 15420 46510460
Hereditary non-polyposis colorectal cancer syndrome 12.52 9.65 7 160175 127 46525753
Incoherent 12.52 9.65 39 160143 4473 46521407
Sleep talking 12.49 9.65 16 160166 951 46524929
Device dislocation 12.48 9.65 36 160146 21766 46504114
Respiration abnormal 12.47 9.65 39 160143 4482 46521398
Ocular hyperaemia 12.45 9.65 31 160151 19679 46506201
Personality change 12.39 9.65 43 160139 5215 46520665
Brief psychotic disorder with marked stressors 12.37 9.65 6 160176 80 46525800
Abnormal sleep-related event 12.33 9.65 14 160168 733 46525147
Normetanephrine urine increased 12.33 9.65 4 160178 16 46525864
Pain in jaw 12.32 9.65 79 160103 38293 46487587
Choreoathetosis 12.31 9.65 11 160171 431 46525449
Anaemia of pregnancy 12.30 9.65 6 160176 81 46525799
Hyperthermia malignant 12.30 9.65 14 160168 735 46525145
Jaundice neonatal 12.30 9.65 15 160167 848 46525032
Hypoalbuminaemia 12.29 9.65 10 160172 10117 46515763
Retinal detachment 12.27 9.65 42 160140 5058 46520822
Myelodysplastic syndrome 12.19 9.65 22 160160 15689 46510191
Attention-seeking behaviour 12.17 9.65 6 160176 83 46525797
Injection site pruritus 12.16 9.65 83 160099 39660 46486220
Bladder dilatation 12.09 9.65 14 160168 749 46525131
Agoraphobia 12.05 9.65 10 160172 354 46525526
Drug resistance 12.03 9.65 26 160156 17342 46508538
Pathogen resistance 11.99 9.65 3 160179 6057 46519823
Brain contusion 11.98 9.65 12 160170 544 46525336
Obsessive rumination 11.97 9.65 3 160179 3 46525877
Antidepressant drug level decreased 11.97 9.65 3 160179 3 46525877
Hypoventilation neonatal 11.97 9.65 3 160179 3 46525877
International normalised ratio increased 11.95 9.65 103 160079 46780 46479100
Skin ulcer 11.92 9.65 64 160118 32394 46493486
Influenza 11.91 9.65 225 159957 89045 46436835
Dry skin 11.90 9.65 87 160095 40929 46484951
Blister 11.85 9.65 97 160085 44534 46481346
Pulmonary oedema 11.85 9.65 115 160067 50990 46474890
Sleep terror 11.78 9.65 14 160168 770 46525110
Full blood count decreased 11.77 9.65 38 160144 22173 46503707
Hypomagnesaemia 11.77 9.65 38 160144 22172 46503708
Neurotoxicity 11.77 9.65 18 160164 13699 46512181
Suspected suicide 11.76 9.65 39 160143 4622 46521258
Myocardial infarction 11.76 9.65 250 159932 97278 46428602
Purging 11.75 9.65 5 160177 48 46525832
Formication 11.73 9.65 35 160147 3921 46521959
Intentional product use issue 11.72 9.65 120 160062 52660 46473220
Unresponsive to stimuli 11.72 9.65 165 160017 32009 46493871
Respiratory rate decreased 11.68 9.65 30 160152 3080 46522800
Narcolepsy 11.68 9.65 17 160165 1142 46524738
Second primary malignancy 11.67 9.65 4 160178 6580 46519300
Jaundice 11.66 9.65 55 160127 28790 46497090
Cerebral vasoconstriction 11.66 9.65 16 160166 1017 46524863
Exposure via transplant 11.62 9.65 4 160178 20 46525860
Hepatic enzyme increased 11.59 9.65 204 159978 81583 46444297
Orgasm abnormal 11.57 9.65 6 160176 93 46525787
Congenital naevus 11.51 9.65 8 160174 216 46525664
Gastritis 11.44 9.65 70 160112 34308 46491572
Focal dyscognitive seizures 11.38 9.65 28 160154 2800 46523080
Osteoporosis 11.37 9.65 87 160095 40521 46485359
Arachnoid cyst 11.35 9.65 8 160174 221 46525659
Rash pruritic 11.33 9.65 97 160085 44118 46481762
Cerebrovascular accident 11.33 9.65 262 159920 100777 46425103
Pancreatic failure 11.31 9.65 12 160170 582 46525298
Somnolence neonatal 11.24 9.65 6 160176 99 46525781
Tubulointerstitial nephritis 11.22 9.65 21 160161 14767 46511113
Haemangioma 11.21 9.65 26 160156 2503 46523377
Xanthopsia 11.21 9.65 7 160175 157 46525723
Wrong technique in product usage process 11.17 9.65 126 160056 54296 46471584
Skin disorder 11.17 9.65 39 160143 22224 46503656
Blood triglycerides increased 11.17 9.65 74 160108 11709 46514171
Mucocutaneous haemorrhage 11.16 9.65 5 160177 55 46525825
Premature rupture of membranes 11.15 9.65 37 160145 4386 46521494
Parkinsonian gait 11.14 9.65 11 160171 490 46525390
Candida infection 11.13 9.65 39 160143 22201 46503679
Pupils unequal 11.13 9.65 18 160164 1326 46524554
Intestinal anastomosis complication 11.10 9.65 8 160174 229 46525651
Localised infection 11.09 9.65 43 160139 23758 46502122
Housebound 11.07 9.65 8 160174 230 46525650
Obsessive-compulsive disorder 11.05 9.65 30 160152 3185 46522695
Fear 11.04 9.65 94 160088 16078 46509802
Joint range of motion decreased 11.02 9.65 22 160160 15102 46510778
Injection site swelling 11.01 9.65 87 160095 40240 46485640
Bronchopulmonary aspergillosis 10.99 9.65 6 160176 7490 46518390
Injection site reaction 10.95 9.65 108 160074 47741 46478139
Increased appetite 10.95 9.65 58 160124 8469 46517411
Glassy eyes 10.92 9.65 5 160177 58 46525822
Hyperemesis gravidarum 10.92 9.65 11 160171 502 46525378
Device difficult to use 10.90 9.65 7 160175 7997 46517883
Urinary retention 10.88 9.65 137 160045 25924 46499956
Nephropathy toxic 10.88 9.65 6 160176 7448 46518432
Neuropsychiatric syndrome 10.85 9.65 5 160177 59 46525821
Anal fissure 10.76 9.65 26 160156 2570 46523310
Congenital pharyngeal anomaly 10.76 9.65 3 160179 6 46525874
Dyskinesia neonatal 10.76 9.65 3 160179 6 46525874
Cardiomyopathy 10.75 9.65 93 160089 15980 46509900
Osteomyelitis 10.71 9.65 40 160142 22343 46503537
Respiratory tract congestion 10.71 9.65 17 160165 12747 46513133
Atrophic vulvovaginitis 10.71 9.65 19 160163 1509 46524371
Cytokine release syndrome 10.65 9.65 4 160178 6219 46519661
Ideas of reference 10.63 9.65 5 160177 62 46525818
Urosepsis 10.62 9.65 23 160159 15330 46510550
Platelet aggregation decreased 10.62 9.65 4 160178 27 46525853
Vision blurred 10.60 9.65 353 159829 79355 46446525
Haemoptysis 10.55 9.65 50 160132 26139 46499741
Accidental exposure to product 10.53 9.65 37 160145 21044 46504836
Impatience 10.53 9.65 9 160173 332 46525548
Hereditary ataxia 10.49 9.65 4 160178 28 46525852
Creutzfeldt-Jakob disease 10.49 9.65 5 160177 64 46525816
Phobia 10.49 9.65 9 160173 334 46525546
Bronchospasm 10.48 9.65 24 160158 15683 46510197
Ovarian cancer stage III 10.44 9.65 7 160175 178 46525702
Haemophagocytic lymphohistiocytosis 10.43 9.65 8 160174 8334 46517546
Middle insomnia 10.42 9.65 62 160120 9453 46516427
Ultrasound abdomen abnormal 10.35 9.65 5 160177 66 46525814
Radius fracture 10.32 9.65 30 160152 3312 46522568
Dissociative amnesia 10.26 9.65 4 160178 30 46525850
Lactation disorder 10.25 9.65 8 160174 259 46525621
Ventricular hypokinesia 10.18 9.65 34 160148 4044 46521836
Wrong patient received product 10.17 9.65 20 160162 1717 46524163
Low birth weight baby 10.16 9.65 3 160179 5431 46520449
Pneumonia viral 10.16 9.65 5 160177 6619 46519261
Blood prolactin increased 10.16 9.65 28 160154 2999 46522881
Polycythaemia 10.15 9.65 13 160169 773 46525107
Congenital foot malformation 10.14 9.65 7 160175 187 46525693
Hypertonia 10.07 9.65 36 160146 4430 46521450
Product formulation issue 10.04 9.65 12 160170 664 46525216
Foetal heart rate deceleration abnormality 10.04 9.65 10 160172 450 46525430
Ocular hypertension 10.04 9.65 13 160169 781 46525099
Therapeutic response decreased 10.04 9.65 97 160085 43048 46482832
Metastases to liver 10.04 9.65 34 160148 19551 46506329
Device leakage 9.97 9.65 3 160179 5362 46520518
Staring 9.95 9.65 18 160164 1452 46524428
Developmental coordination disorder 9.93 9.65 4 160178 33 46525847
Injection site haemorrhage 9.91 9.65 37 160145 20672 46505208
Neonatal intestinal obstruction 9.91 9.65 3 160179 9 46525871
Crush injury 9.91 9.65 3 160179 9 46525871
Phaeochromocytoma 9.90 9.65 10 160172 458 46525422
Drug withdrawal convulsions 9.82 9.65 17 160165 1324 46524556
Hyperchloraemia 9.80 9.65 12 160170 681 46525199
Polydactyly 9.79 9.65 9 160173 366 46525514
Hypnagogic hallucination 9.79 9.65 6 160176 130 46525750
Pleural disorder 9.77 9.65 11 160171 571 46525309
Haemorrhage 9.77 9.65 131 160051 54738 46471142
Amphetamines positive 9.73 9.65 5 160177 76 46525804
Obstructive airways disorder 9.72 9.65 79 160103 13333 46512547
Communication disorder 9.69 9.65 24 160158 2409 46523471
Non-small cell lung cancer recurrent 9.67 9.65 3 160179 10 46525870
Urinary tract discomfort 9.67 9.65 5 160177 77 46525803
Pseudophaeochromocytoma 9.67 9.65 5 160177 77 46525803
Dehydration 9.66 9.65 448 159734 159092 46366788
Exposure via ingestion 9.65 9.65 30 160152 3437 46522443

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 799.42 10.56 1058 67537 98434 29785449
Serotonin syndrome 644.26 10.56 439 68156 17452 29866431
Drug withdrawal syndrome 454.78 10.56 371 68224 19438 29864445
Suicide attempt 431.13 10.56 474 68121 36223 29847660
Suicidal ideation 407.92 10.56 457 68138 35657 29848226
Intentional overdose 396.91 10.56 482 68113 40999 29842884
Toxicity to various agents 385.37 10.56 1079 67516 176104 29707779
Depression 277.04 10.56 628 67967 89809 29794074
Overdose 264.27 10.56 591 68004 83746 29800137
Withdrawal syndrome 201.72 10.56 183 68412 11067 29872816
Anxiety 191.40 10.56 544 68051 89327 29794556
Agitation 161.47 10.56 372 68223 53701 29830182
Maternal exposure during pregnancy 161.01 10.56 104 68491 3767 29880116
Mania 152.64 10.56 143 68452 9011 29874872
Hyperhidrosis 140.68 10.56 404 68191 66686 29817197
Coma 138.48 10.56 294 68301 40155 29843728
Disturbance in attention 137.98 10.56 209 68386 21920 29861963
Pneumonia 137.47 10.56 357 68238 333949 29549934
Drug interaction 134.95 10.56 849 67746 198719 29685164
Febrile neutropenia 132.26 10.56 40 68555 106653 29777230
Poisoning deliberate 132.08 10.56 109 68486 5795 29878088
Mydriasis 128.30 10.56 109 68486 6034 29877849
Exposure during pregnancy 125.19 10.56 129 68466 9132 29874751
Selective eating disorder 122.48 10.56 65 68530 1619 29882264
Drug withdrawal syndrome neonatal 119.16 10.56 80 68515 3095 29880788
Respiratory disorder neonatal 119.15 10.56 57 68538 1131 29882752
Foetal exposure during pregnancy 118.20 10.56 261 68334 36610 29847273
Drug abuse 117.59 10.56 434 68161 81638 29802245
Anaemia 116.04 10.56 186 68409 207806 29676077
Intentional self-injury 112.93 10.56 147 68448 13385 29870498
Hypotonia neonatal 111.27 10.56 52 68543 977 29882906
Pyrexia 110.14 10.56 329 68266 294160 29589723
Somnolence 109.23 10.56 475 68120 96288 29787595
Tremor 107.50 10.56 398 68197 74965 29808918
Major depression 106.53 10.56 82 68513 3940 29879943
Neonatal respiratory distress syndrome 100.20 10.56 79 68516 3933 29879950
Restlessness 93.75 10.56 178 68417 22421 29861462
Hyperreflexia 93.49 10.56 66 68529 2773 29881110
Cataplexy 92.12 10.56 34 68561 339 29883544
Sepsis 91.29 10.56 121 68474 146274 29737609
Irritability 88.84 10.56 176 68419 22874 29861009
Sopor 88.00 10.56 117 68478 10874 29873009
Drug dependence 87.43 10.56 167 68428 21128 29862755
Rash 82.43 10.56 200 68395 191689 29692194
Dyspnoea 81.12 10.56 441 68154 332854 29551029
Aggression 80.95 10.56 226 68369 36681 29847202
Myoclonus 79.12 10.56 123 68472 13189 29870694
Bipolar disorder 74.78 10.56 65 68530 3711 29880172
Acute kidney injury 74.75 10.56 348 68247 273494 29610389
Seizure 74.64 10.56 432 68163 98043 29785840
Diarrhoea 73.83 10.56 456 68139 333647 29550236
Poisoning 73.06 10.56 109 68486 11273 29872610
Talipes 72.12 10.56 46 68549 1629 29882254
Bradycardia neonatal 68.44 10.56 36 68559 880 29883003
Agitation neonatal 67.39 10.56 37 68558 988 29882895
Infantile apnoea 66.60 10.56 35 68560 854 29883029
Neutropenia 66.02 10.56 121 68474 128419 29755464
Psychotic disorder 65.23 10.56 149 68446 21366 29862517
Anger 65.05 10.56 102 68493 11018 29872865
Death 64.08 10.56 518 68077 356765 29527118
Erectile dysfunction 63.56 10.56 133 68462 17969 29865914
Small for dates baby 63.08 10.56 55 68540 3153 29880730
Postmortem blood drug level increased 62.99 10.56 20 68575 120 29883763
Atrial septal defect 62.57 10.56 77 68518 6624 29877259
Depressed mood 62.00 10.56 127 68468 16902 29866981
Interstitial lung disease 60.68 10.56 31 68564 60166 29823717
Sedation 59.48 10.56 122 68473 16251 29867632
Hallucination, auditory 58.94 10.56 91 68504 9698 29874185
Nightmare 58.82 10.56 102 68493 11974 29871909
Electrocardiogram QT prolonged 58.55 10.56 198 68397 35637 29848246
Maternal drugs affecting foetus 56.80 10.56 59 68536 4214 29879669
Delusion 56.75 10.56 100 68495 11889 29871994
Insomnia 56.70 10.56 387 68208 92949 29790934
Homicide 55.96 10.56 33 68562 1013 29882870
Hallucination, visual 54.96 10.56 117 68478 15996 29867887
Psychotic symptom 54.57 10.56 34 68561 1155 29882728
Cardiac failure congestive 54.37 10.56 68 68527 84339 29799544
Dyskinesia 54.20 10.56 140 68455 21694 29862189
Off label use 54.05 10.56 342 68253 248948 29634935
Malignant neoplasm progression 53.42 10.56 52 68543 72235 29811648
Disease progression 51.81 10.56 64 68531 79810 29804073
Platelet count decreased 51.76 10.56 103 68492 106026 29777857
Antipsychotic drug level above therapeutic 50.13 10.56 31 68564 1039 29882844
Rheumatoid arthritis 50.00 10.56 16 68579 41181 29842702
Renal impairment 49.98 10.56 72 68523 84112 29799771
Somnambulism 49.38 10.56 48 68547 3166 29880717
Tachycardia 49.17 10.56 313 68282 73426 29810457
Haemoglobin decreased 48.06 10.56 120 68475 113978 29769905
Hypertonia neonatal 47.59 10.56 21 68574 343 29883540
Impulsive behaviour 47.58 10.56 38 68557 1927 29881956
Cough 47.04 10.56 140 68455 125502 29758381
Hypertonia 46.89 10.56 54 68541 4331 29879552
Sexual dysfunction 46.69 10.56 63 68532 5938 29877945
Antidepressant drug level increased 46.55 10.56 15 68580 95 29883788
Neuroleptic malignant syndrome 46.27 10.56 110 68485 16185 29867698
Plasma cell myeloma 46.23 10.56 33 68562 53429 29830454
Pruritus 45.49 10.56 130 68465 118074 29765809
Neonatal tachypnoea 44.67 10.56 15 68580 110 29883773
Altered state of consciousness 43.68 10.56 122 68473 19797 29864086
Neuropathy peripheral 43.10 10.56 59 68536 70416 29813467
Confusional state 42.99 10.56 485 68110 134349 29749534
Parkinsonism 42.96 10.56 67 68528 7202 29876681
Akathisia 42.94 10.56 60 68535 5844 29878039
Cytomegalovirus infection 42.55 10.56 3 68592 23671 29860212
Erythema 42.37 10.56 70 68525 77381 29806502
Feeling jittery 42.19 10.56 48 68547 3800 29880083
Panic attack 41.85 10.56 73 68522 8608 29875275
Drug screen positive 41.73 10.56 51 68544 4356 29879527
Thrombocytopenia 41.64 10.56 167 68428 136877 29747006
Infection 41.39 10.56 72 68523 78002 29805881
Electrocardiogram QRS complex prolonged 41.32 10.56 50 68545 4227 29879656
Septic shock 41.21 10.56 51 68544 63556 29820327
Hypomania 41.02 10.56 37 68558 2219 29881664
Self-injurious ideation 40.86 10.56 32 68563 1577 29882306
Respiratory failure 40.72 10.56 108 68487 100534 29783349
Multiple organ dysfunction syndrome 39.99 10.56 52 68543 63435 29820448
Memory impairment 39.97 10.56 180 68415 36994 29846889
Stress cardiomyopathy 39.75 10.56 31 68564 1518 29882365
Social anxiety disorder 39.66 10.56 17 68578 258 29883625
Miosis 39.60 10.56 67 68528 7709 29876174
Product substitution issue 39.11 10.56 77 68518 9958 29873925
Intentional product misuse 38.89 10.56 170 68425 34497 29849386
Pancytopenia 38.56 10.56 86 68509 84966 29798917
Bone marrow failure 37.16 10.56 11 68584 29774 29854109
Paranoia 35.93 10.56 75 68520 10113 29873770
Gastrointestinal haemorrhage 35.72 10.56 87 68508 83359 29800524
Feeling abnormal 35.43 10.56 237 68358 56519 29827364
Atrial fibrillation 35.26 10.56 128 68467 107996 29775887
Hepatic function abnormal 34.83 10.56 27 68568 41918 29841965
Homicidal ideation 34.53 10.56 35 68560 2428 29881455
Clonus 34.32 10.56 35 68560 2446 29881437
Blood creatinine increased 34.05 10.56 102 68493 91273 29792610
Feelings of worthlessness 34.00 10.56 14 68581 191 29883692
Logorrhoea 33.70 10.56 32 68563 2050 29881833
Pleural effusion 33.48 10.56 75 68520 73991 29809892
Premature baby 33.46 10.56 99 68496 16592 29867291
Mucosal inflammation 33.36 10.56 14 68581 30480 29853403
Neonatal toxicity 33.32 10.56 9 68586 27 29883856
Muscle rigidity 33.26 10.56 73 68522 10188 29873695
Abnormal behaviour 32.92 10.56 131 68464 25492 29858391
Thinking abnormal 32.86 10.56 50 68545 5261 29878622
Macrophages increased 32.71 10.56 13 68582 161 29883722
Tearfulness 32.67 10.56 28 68567 1568 29882315
Libido decreased 32.61 10.56 46 68549 4520 29879363
Apgar score low 32.49 10.56 22 68573 863 29883020
Multiple drug therapy 31.49 10.56 14 68581 233 29883650
Arthralgia 31.07 10.56 183 68412 135608 29748275
Stomatitis 30.95 10.56 24 68571 37255 29846628
Mood altered 30.58 10.56 62 68533 8188 29875695
Tardive dyskinesia 30.43 10.56 47 68548 5010 29878873
Normal pressure hydrocephalus 30.31 10.56 12 68583 147 29883736
Abnormal dreams 30.10 10.56 61 68534 8054 29875829
Ejaculation disorder 30.07 10.56 22 68573 978 29882905
Disorientation 30.02 10.56 147 68448 31271 29852612
Poor quality sleep 29.97 10.56 57 68538 7184 29876699
Cognitive disorder 29.54 10.56 120 68475 23570 29860313
Psychomotor hyperactivity 29.54 10.56 61 68534 8163 29875720
Sleep apnoea syndrome 29.18 10.56 95 68500 16762 29867121
Dysphoria 29.17 10.56 30 68565 2118 29881765
Myocardial fibrosis 29.07 10.56 19 68576 702 29883181
Weight increased 28.81 10.56 280 68315 74633 29809250
Fall 28.75 10.56 580 68015 181292 29702591
Urinary retention 28.63 10.56 150 68445 32767 29851116
Chronic kidney disease 28.20 10.56 27 68568 37811 29846072
Disseminated intravascular coagulation 28.00 10.56 8 68587 22163 29861720
Encephalopathy neonatal 27.85 10.56 8 68587 32 29883851
Muscle twitching 27.56 10.56 59 68536 8096 29875787
Depression suicidal 27.38 10.56 23 68572 1253 29882630
Respiratory arrest 27.31 10.56 136 68459 29122 29854761
Electric shock 27.20 10.56 11 68584 143 29883740
Neonatal disorder 27.00 10.56 20 68575 906 29882977
Stevens-Johnson syndrome 26.98 10.56 4 68591 17552 29866331
Extrapyramidal disorder 26.98 10.56 69 68526 10624 29873259
Alcoholism 26.80 10.56 36 68559 3378 29880505
Mental impairment 26.74 10.56 63 68532 9214 29874669
Oedema peripheral 26.73 10.56 138 68457 105694 29778189
Acoustic stimulation tests abnormal 26.46 10.56 9 68586 69 29883814
Pressure of speech 26.45 10.56 15 68580 427 29883456
Hyperthermia 26.35 10.56 66 68529 10033 29873850
Implant site extravasation 26.23 10.56 15 68580 434 29883449
Blood ethanol increased 26.15 10.56 14 68581 355 29883528
Pneumocystis jirovecii pneumonia 26.09 10.56 4 68591 17116 29866767
Sleep disorder 25.91 10.56 118 68477 24361 29859522
Head circumference abnormal 25.78 10.56 8 68587 44 29883839
Obsessive-compulsive disorder 25.64 10.56 39 68556 4102 29879781
Cardio-respiratory arrest 25.47 10.56 221 68374 57085 29826798
Neonatal testicular torsion 25.41 10.56 5 68590 0 29883883
Product residue present 25.37 10.56 31 68564 2647 29881236
Otospondylomegaepiphyseal dysplasia 25.29 10.56 10 68585 122 29883761
Dry mouth 24.82 10.56 111 68484 22739 29861144
Neonatal respiratory failure 24.78 10.56 13 68582 316 29883567
Peritonitis 24.72 10.56 9 68586 21366 29862517
Restless legs syndrome 24.71 10.56 51 68544 6821 29877062
Thermophobia 24.54 10.56 9 68586 88 29883795
Foetal malnutrition 24.52 10.56 8 68587 53 29883830
Acute myocardial infarction 24.42 10.56 53 68542 52886 29830997
International normalised ratio increased 24.41 10.56 45 68550 47694 29836189
External auditory canal atresia 24.38 10.56 10 68585 135 29883748
Drug hypersensitivity 24.36 10.56 252 68343 68267 29815616
Patent ductus arteriosus 24.24 10.56 33 68562 3136 29880747
Pyramidal tract syndrome 24.11 10.56 11 68584 195 29883688
Wrong dose 23.88 10.56 13 68582 341 29883542
Hypospadias 23.75 10.56 30 68565 2649 29881234
Pneumonitis 23.65 10.56 17 68578 27437 29856446
Eosinophilic myocarditis 23.64 10.56 14 68581 433 29883450
Blood cholesterol increased 23.63 10.56 89 68506 16881 29867002
Arachnoid cyst 23.33 10.56 11 68584 211 29883672
Bipolar II disorder 23.30 10.56 6 68589 14 29883869
Apathy 23.30 10.56 47 68548 6185 29877698
Euphoric mood 23.23 10.56 38 68557 4252 29879631
Cerebral infarction 23.16 10.56 16 68579 26357 29857526
Neonatal respiratory distress 23.05 10.56 14 68581 454 29883429
Decreased appetite 22.92 10.56 226 68369 149684 29734199
Congenital megaureter 22.90 10.56 9 68586 108 29883775
Renal aplasia 22.88 10.56 16 68579 662 29883221
Infusion related reaction 22.79 10.56 36 68559 40528 29843355
Tremor neonatal 22.77 10.56 13 68582 375 29883508
Cardiac failure 22.65 10.56 106 68489 83312 29800571
Renal failure 22.51 10.56 188 68407 128778 29755105
Joint swelling 22.49 10.56 46 68549 46900 29836983
Salivary hypersecretion 22.48 10.56 52 68543 7514 29876369
Depressive symptom 22.38 10.56 23 68572 1622 29882261
Paraesthesia 22.34 10.56 206 68389 54121 29829762
Metabolic syndrome 22.02 10.56 22 68573 1500 29882383
Anaphylactic reaction 22.00 10.56 19 68576 27963 29855920
Iris coloboma 21.97 10.56 6 68589 19 29883864
Norepinephrine increased 21.95 10.56 5 68590 5 29883878
Retinal coloboma 21.74 10.56 6 68589 20 29883863
Priapism 21.72 10.56 39 68556 4704 29879179
Muscle mass 21.48 10.56 11 68584 254 29883629
Testicular atrophy 21.45 10.56 14 68581 516 29883367
Condition aggravated 21.21 10.56 438 68157 137428 29746455
Histamine level increased 21.13 10.56 7 68588 49 29883834
Mood swings 21.13 10.56 51 68544 7575 29876308
Personality disorder 21.11 10.56 19 68576 1136 29882747
Kidney duplex 21.09 10.56 12 68583 344 29883539
Toxic cardiomyopathy 21.06 10.56 10 68585 195 29883688
Poor sucking reflex 20.98 10.56 11 68584 267 29883616
Emotional disorder 20.96 10.56 40 68555 5054 29878829
Persistent depressive disorder 20.91 10.56 11 68584 269 29883614
Coagulation disorder neonatal 20.89 10.56 6 68589 24 29883859
White blood cell count decreased 20.88 10.56 110 68485 83837 29800046
Penoscrotal fusion 20.65 10.56 5 68590 8 29883875
Gun shot wound 20.51 10.56 19 68576 1179 29882704
Pulmonary contusion 20.43 10.56 7 68588 55 29883828
Loose associations 20.43 10.56 7 68588 55 29883828
Onychomycosis 20.43 10.56 25 68570 2138 29881745
Cerebrovascular accident 20.42 10.56 110 68485 83367 29800516
Haematoma 20.42 10.56 15 68580 23938 29859945
Hypervigilance 20.34 10.56 9 68586 148 29883735
Inappropriate antidiuretic hormone secretion 20.33 10.56 65 68530 11357 29872526
Dyskinesia neonatal 20.33 10.56 4 68591 0 29883883
Bruxism 20.32 10.56 20 68575 1339 29882544
External ear disorder 20.32 10.56 6 68589 27 29883856
Hyperkalaemia 20.30 10.56 80 68515 65930 29817953
Loss of consciousness 20.27 10.56 274 68321 79101 29804782
Decreased interest 20.13 10.56 25 68570 2170 29881713
Foaming at mouth 20.09 10.56 15 68580 688 29883195
Myelodysplastic syndrome 19.94 10.56 9 68586 18769 29865114
Electrocardiogram QT shortened 19.86 10.56 9 68586 157 29883726
Epilepsy 19.71 10.56 95 68500 20074 29863809
Congenital central nervous system anomaly 19.57 10.56 12 68583 396 29883487
Temperature regulation disorder 19.45 10.56 13 68582 499 29883384
Heat stroke 19.33 10.56 16 68579 854 29883029
Alopecia 19.30 10.56 10 68585 19265 29864618
Amnesia 19.23 10.56 108 68487 24213 29859670
Enuresis 19.23 10.56 22 68573 1752 29882131
Ascites 19.14 10.56 33 68562 35888 29847995
Liver disorder 19.06 10.56 24 68571 29698 29854185
Persecutory delusion 19.03 10.56 24 68571 2116 29881767
Rhabdomyolysis 19.01 10.56 226 68369 63354 29820529
Affective disorder 18.86 10.56 29 68566 3079 29880804
Delirium 18.74 10.56 158 68437 40473 29843410
Splenomegaly 18.70 10.56 4 68591 13476 29870407
Violence-related symptom 18.67 10.56 13 68582 534 29883349
Colitis 18.63 10.56 26 68569 30794 29853089
Gastrointestinal hypermotility 18.63 10.56 8 68587 122 29883761
Accommodation disorder 18.48 10.56 9 68586 186 29883697
Suicidal behaviour 18.45 10.56 19 68576 1343 29882540
Dizziness 18.39 10.56 580 68015 194329 29689554
Cerebral ventricle dilatation 18.34 10.56 15 68580 787 29883096
Blood bilirubin increased 18.32 10.56 35 68560 36601 29847282
Loss of libido 18.32 10.56 23 68572 2019 29881864
Crying 18.29 10.56 40 68555 5569 29878314
Drug reaction with eosinophilia and systemic symptoms 18.27 10.56 23 68572 28465 29855418
Hangover 18.27 10.56 17 68578 1061 29882822
Maternal exposure timing unspecified 18.21 10.56 11 68584 353 29883530
Urticaria 18.21 10.56 64 68531 54542 29829341
Diarrhoea neonatal 18.04 10.56 5 68590 17 29883866
Bradykinesia 18.02 10.56 29 68566 3201 29880682
Rebound effect 18.01 10.56 20 68575 1541 29882342
Blunted affect 17.85 10.56 10 68585 278 29883605
Social avoidant behaviour 17.77 10.56 27 68568 2836 29881047
Visual evoked potentials abnormal 17.73 10.56 7 68588 85 29883798
Floppy infant 17.66 10.56 7 68588 86 29883797
Generalised tonic-clonic seizure 17.63 10.56 90 68505 19461 29864422
Sleep paralysis 17.58 10.56 8 68587 141 29883742
Peripheral swelling 17.54 10.56 76 68519 60998 29822885
Catatonia 17.54 10.56 34 68561 4346 29879537
Oedema 17.47 10.56 46 68549 42947 29840936
Bradyphrenia 17.44 10.56 32 68563 3925 29879958
Hypoxia 17.39 10.56 54 68541 47800 29836083
Prescribed overdose 17.37 10.56 51 68544 8510 29875373
Male orgasmic disorder 17.31 10.56 7 68588 91 29883792
Drug screen false positive 17.27 10.56 14 68581 725 29883158
Food aversion 17.25 10.56 10 68585 297 29883586
Influenza 17.21 10.56 47 68548 43351 29840532
Selective mutism 17.10 10.56 6 68589 51 29883832
Physical examination abnormal 17.04 10.56 7 68588 95 29883788
Infantile vomiting 17.03 10.56 5 68590 22 29883861
Affect lability 16.81 10.56 29 68566 3389 29880494
Phaeochromocytoma malignant 16.80 10.56 6 68589 54 29883829
Haematuria 16.72 10.56 50 68545 44784 29839099
Dysgraphia 16.62 10.56 19 68576 1512 29882371
Physical assault 16.58 10.56 17 68578 1196 29882687
Diastolic hypotension 16.51 10.56 5 68590 25 29883858
Blood creatine phosphokinase increased 16.41 10.56 163 68432 43685 29840198
Lymphadenopathy 16.36 10.56 19 68576 24357 29859526
Bronchopulmonary aspergillosis 16.33 10.56 4 68591 12280 29871603
Action tremor 16.33 10.56 6 68589 59 29883824
Potentiating drug interaction 16.22 10.56 34 68561 4597 29879286
Micturition urgency 16.19 10.56 33 68562 4374 29879509
Hospitalisation 16.12 10.56 50 68545 44269 29839614
Derealisation 16.06 10.56 12 68583 551 29883332
Palmar-plantar erythrodysaesthesia syndrome 15.99 10.56 7 68588 14863 29869020
Thrombosis 15.82 10.56 47 68548 42184 29841699
Product dose omission issue 15.79 10.56 134 68461 91497 29792386
Contraindicated product administered 15.74 10.56 10 68585 17221 29866662
Chills 15.73 10.56 99 68496 72239 29811644
Acute myeloid leukaemia 15.71 10.56 11 68584 17995 29865888
Dissociation 15.66 10.56 16 68579 1121 29882762
Coagulation factor VII level decreased 15.61 10.56 7 68588 119 29883764
Psychomotor retardation 15.58 10.56 23 68572 2356 29881527
Anal stenosis 15.56 10.56 7 68588 120 29883763
Cyanosis neonatal 15.51 10.56 9 68586 268 29883615
Stress 15.44 10.56 89 68506 20146 29863737
Obsessive-compulsive symptom 15.42 10.56 6 68589 70 29883813
Cerebral disorder 15.35 10.56 23 68572 2387 29881496
Cerebral microangiopathy 15.34 10.56 8 68587 192 29883691
Forearm fracture 15.34 10.56 6 68589 71 29883812
Withdrawal catatonia 15.26 10.56 6 68589 72 29883811
Kleptomania 15.24 10.56 3 68592 0 29883883
Tinnitus 15.17 10.56 75 68520 16013 29867870
Anorgasmia 15.12 10.56 12 68583 603 29883280
Wheezing 15.08 10.56 30 68565 30908 29852975
Hepatic failure 14.95 10.56 35 68560 34008 29849875
CADASIL 14.90 10.56 6 68589 77 29883806
Ultrasound skull abnormal 14.90 10.56 6 68589 77 29883806
Opisthotonus 14.87 10.56 10 68585 388 29883495
Meningocele 14.85 10.56 5 68590 37 29883846
Head discomfort 14.85 10.56 25 68570 2865 29881018
Dysarthria 14.82 10.56 120 68475 30370 29853513
Rash maculo-papular 14.81 10.56 22 68573 25396 29858487
Blood urea increased 14.81 10.56 31 68564 31350 29852533
Urinary straining 14.81 10.56 4 68591 12 29883871
Physical deconditioning 14.76 10.56 12 68583 624 29883259
Unemployment 14.74 10.56 5 68590 38 29883845
Hypomagnesaemia 14.66 10.56 10 68585 16588 29867295
Magnetic resonance imaging spinal abnormal 14.63 10.56 6 68589 81 29883802
Reduced facial expression 14.59 10.56 13 68582 767 29883116
Abnormal palmar/plantar creases 14.56 10.56 8 68587 214 29883669
Muscle necrosis 14.53 10.56 13 68582 771 29883112
Tricuspid valve sclerosis 14.51 10.56 5 68590 40 29883843
Fatigue 14.51 10.56 594 68001 320079 29563804
Antipsychotic drug level increased 14.46 10.56 26 68569 3140 29880743
Developmental delay 14.45 10.56 21 68574 2120 29881763
Foetal arrhythmia 14.37 10.56 6 68589 85 29883798
Tunnel vision 14.27 10.56 10 68585 415 29883468
Tubulointerstitial nephritis 14.24 10.56 12 68583 17879 29866004
Aspergillus infection 14.23 10.56 3 68592 10211 29873672
Joint hyperextension 14.20 10.56 5 68590 43 29883840
Renal disorder 14.15 10.56 20 68575 23564 29860319
Rhinorrhoea 14.12 10.56 16 68579 20738 29863145
Congenital hydronephrosis 14.11 10.56 12 68583 665 29883218
Pseudohyponatraemia 14.06 10.56 6 68589 90 29883793
Congenital skin dimples 14.06 10.56 7 68588 152 29883731
Tumour lysis syndrome 13.96 10.56 6 68589 12879 29871004
Food craving 13.93 10.56 9 68586 326 29883557
Insulin resistance 13.89 10.56 11 68584 551 29883332
Substance abuser 13.88 10.56 6 68589 93 29883790
Gambling disorder 13.83 10.56 19 68576 1821 29882062
Nonspecific reaction 13.82 10.56 16 68579 1290 29882593
Sexually inappropriate behaviour 13.81 10.56 9 68586 331 29883552
Dehydration 13.60 10.56 200 68395 123339 29760544
Large cell lung cancer metastatic 13.55 10.56 4 68591 18 29883865
General physical health deterioration 13.51 10.56 155 68440 99789 29784094
Hypotension 13.47 10.56 353 68242 200212 29683671
Panic disorder 13.47 10.56 15 68580 1160 29882723
Flight of ideas 13.41 10.56 9 68586 348 29883535
Central nervous system inflammation 13.38 10.56 6 68589 102 29883781
Nervousness 13.36 10.56 58 68537 11730 29872153
Food interaction 13.31 10.56 13 68582 862 29883021
Clostridium difficile infection 13.30 10.56 10 68585 15773 29868110
Urine output decreased 13.27 10.56 3 68592 9726 29874157
Coma scale abnormal 13.27 10.56 26 68569 3350 29880533
Double stranded DNULL antibody positive 13.22 10.56 6 68589 105 29883778
Foetal damage 13.17 10.56 3 68592 3 29883880
Hypoglycaemia 13.13 10.56 66 68529 50915 29832968
Heart rate increased 13.09 10.56 141 68454 38580 29845303
Toxicologic test abnormal 13.05 10.56 11 68584 602 29883281
Hepatocellular carcinoma 13.03 10.56 3 68592 9607 29874276
Inhibitory drug interaction 13.02 10.56 17 68578 1551 29882332
Productive cough 12.99 10.56 31 68564 29922 29853961
Inflammation 12.90 10.56 19 68576 22007 29861876
Hypertensive urgency 12.87 10.56 5 68590 58 29883825
Skull fractured base 12.85 10.56 7 68588 184 29883699
Conjunctivitis viral 12.72 10.56 5 68590 60 29883823
Blepharospasm 12.69 10.56 13 68582 913 29882970
Implant site infection 12.66 10.56 13 68582 916 29882967
Leukopenia 12.65 10.56 76 68519 56083 29827800
Pneumonia bacterial 12.62 10.56 3 68592 9400 29874483
Pericardial effusion 12.62 10.56 18 68577 21126 29862757
Sclerodactylia 12.60 10.56 4 68591 24 29883859
Neonatal hypotension 12.59 10.56 6 68589 118 29883765
Attention deficit hyperactivity disorder 12.47 10.56 18 68577 1806 29882077
Renal tubular necrosis 12.43 10.56 10 68585 15241 29868642
Small intestinal obstruction 12.38 10.56 8 68587 13651 29870232
Haemangioma congenital 12.37 10.56 10 68585 516 29883367
Diverticulitis 12.36 10.56 13 68582 17432 29866451
Alcoholic liver disease 12.36 10.56 11 68584 648 29883235
Hypokalaemia 12.35 10.56 66 68529 50126 29833757
Convulsive threshold lowered 12.32 10.56 10 68585 519 29883364
Hypersomnia 12.31 10.56 55 68540 11261 29872622
Pain in extremity 12.28 10.56 178 68417 110043 29773840
Myocardial infarction 12.28 10.56 208 68387 125417 29758466
Hepatocellular injury 12.25 10.56 100 68495 25371 29858512
Haemorrhage 12.24 10.56 59 68536 46020 29837863
Dysphemia 12.21 10.56 16 68579 1465 29882418
Mental disorder 12.18 10.56 62 68533 13387 29870496
Substance dependence 12.16 10.56 9 68586 407 29883476
Cogwheel rigidity 12.16 10.56 14 68581 1122 29882761
Neoplasm progression 12.14 10.56 14 68581 18009 29865874
Psoriasis 12.14 10.56 53 68542 42453 29841430
Ex-drug abuser 12.10 10.56 7 68588 207 29883676
Parkinsonian rest tremor 12.10 10.56 6 68589 129 29883754
Limited symptom panic attack 12.09 10.56 5 68590 69 29883814
Muscle tightness 12.09 10.56 30 68565 4533 29879350
Neutrophil count decreased 12.08 10.56 53 68542 42401 29841482
Haemoptysis 12.07 10.56 34 68561 31044 29852839
Accidental death 12.06 10.56 19 68576 2060 29881823
Self esteem decreased 12.04 10.56 10 68585 536 29883347
Immune reconstitution inflammatory syndrome 12.03 10.56 3 68592 9098 29874785
Saccadic eye movement 12.02 10.56 6 68589 131 29883752
Toxic epidermal necrolysis 12.02 10.56 14 68581 17926 29865957
Squamous cell carcinoma of skin 12.02 10.56 3 68592 9092 29874791
Cerebellar syndrome 11.97 10.56 19 68576 2073 29881810
Magical thinking 11.96 10.56 3 68592 6 29883877
C-reactive protein increased 11.94 10.56 55 68540 43418 29840465
Vertebral foraminal stenosis 11.93 10.56 10 68585 543 29883340
COVID-19 11.93 10.56 14 68581 17864 29866019
Pulmonary eosinophilia 11.92 10.56 7 68588 213 29883670
Foetal heart rate disorder 11.83 10.56 4 68591 30 29883853
Adrenocorticotropic hormone deficiency 11.75 10.56 9 68586 429 29883454
Tryptase increased 11.75 10.56 7 68588 219 29883664
Drug abuser 11.73 10.56 29 68566 4372 29879511
Delayed fontanelle closure 11.72 10.56 4 68591 31 29883852
Hypersensitivity 11.71 10.56 74 68521 53954 29829929
Bacteraemia 11.71 10.56 11 68584 15549 29868334
Sinus tachycardia 11.70 10.56 68 68527 15436 29868447
Central nervous system stimulation 11.65 10.56 3 68592 7 29883876
Blood potassium increased 11.58 10.56 12 68583 16201 29867682
Nasopharyngitis 11.56 10.56 83 68512 58766 29825117
Dyspnoea exertional 11.49 10.56 42 68553 35388 29848495
Exposure via breast milk 11.47 10.56 16 68579 1556 29882327
Candida infection 11.40 10.56 11 68584 15351 29868532
Impulse-control disorder 11.39 10.56 15 68580 1380 29882503
Psychomotor skills impaired 11.36 10.56 18 68577 1961 29881922
Naevus flammeus 11.36 10.56 6 68589 148 29883735
Flashback 11.36 10.56 6 68589 148 29883735
Craniocerebral injury 11.35 10.56 22 68573 2811 29881072
Coronary artery disease 11.34 10.56 67 68528 49645 29834238
Alcohol poisoning 11.33 10.56 26 68569 3738 29880145
Congenital mitral valve incompetence 11.31 10.56 5 68590 82 29883801
Narcolepsy 11.29 10.56 9 68586 455 29883428
Hepatotoxicity 11.28 10.56 15 68580 18130 29865753
Oromandibular dystonia 11.27 10.56 9 68586 456 29883427
Sexual activity increased 11.20 10.56 4 68591 36 29883847
Chronic obstructive pulmonary disease 11.15 10.56 61 68534 46065 29837818
Enterocolitis bacterial 11.12 10.56 7 68588 242 29883641
Newborn persistent pulmonary hypertension 11.05 10.56 5 68590 87 29883796
Angioedema 11.00 10.56 41 68554 34343 29849540
Hypotonia 11.00 10.56 38 68557 6910 29876973
Blood pressure decreased 10.98 10.56 63 68532 47012 29836871
Cerebellar haematoma 10.95 10.56 7 68588 249 29883634
Necrotising ulcerative gingivostomatitis 10.94 10.56 5 68590 89 29883794
Hiccups 10.86 10.56 4 68591 9430 29874453
Skin exfoliation 10.84 10.56 23 68572 23149 29860734
Lip swelling 10.84 10.56 8 68587 12736 29871147
Suspected suicide 10.83 10.56 23 68572 3138 29880745
Full blood count decreased 10.82 10.56 12 68583 15705 29868178
Feeling of despair 10.77 10.56 12 68583 928 29882955
Libido disorder 10.75 10.56 7 68588 257 29883626
Urinary hesitation 10.74 10.56 19 68576 2265 29881618
Imprisonment 10.73 10.56 9 68586 489 29883394
Generalised oedema 10.72 10.56 7 68588 11878 29872005
Upper respiratory tract infection 10.71 10.56 30 68565 27446 29856437
Asphyxia 10.70 10.56 32 68563 5393 29878490
Foetal hypokinesia 10.68 10.56 8 68587 369 29883514
Gonadotrophin deficiency 10.65 10.56 4 68591 42 29883841
Spondylolisthesis 10.58 10.56 11 68584 786 29883097

Pharmacologic Action:

SourceCodeDescription
ATC N06AX16 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
FDA EPC N0000175749 Serotonin and Norepinephrine Reuptake Inhibitor
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D000068760 Serotonin and Noradrenaline Reuptake Inhibitors
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50949 serotonin reuptake inhibitor
CHEBI has role CHEBI:51039 dopamine reuptake inhibitors
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Social phobia indication 25501002 DOID:11257
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Menopausal flushing off-label use 198436008
Neuropathic pain off-label use 247398009
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperthyroidism contraindication 34486009 DOID:7998
Upper gastrointestinal hemorrhage contraindication 37372002
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Mania contraindication 231494001
Hypomania contraindication 231496004
Interstitial lung disease contraindication 233703007 DOID:3082
Disease of liver contraindication 235856003 DOID:409
Hypertriglyceridemia contraindication 302870006
Serotonin syndrome contraindication 371089000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 5.97 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.05 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.65 PDSP
5-hydroxytryptamine receptor 6 GPCR Ki 5.55 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.44 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 5.70 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.05 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.44 CHEMBL
Transporter Transporter IC50 6.19 CHEMBL
Transporter Transporter Ki 6.86 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 7.60 CHEMBL

External reference:

IDSource
4023901 VUID
N0000021906 NUI
D00821 KEGG_DRUG
99300-78-4 SECONDARY_CAS_RN
4020846 VANDF
4023901 VANDF
C0591437 UMLSCUI
CHEBI:9943 CHEBI
CHEMBL637 ChEMBL_ID
CHEMBL1201066 ChEMBL_ID
D000069470 MESH_DESCRIPTOR_UI
5656 PUBCHEM_CID
6358 INN_ID
DB00285 DRUGBANK_ID
GRZ5RCB1QG UNII
7321 IUPHAR_LIGAND_ID
151692 RXNORM
5669 MMSL
594 MMSL
87651 MMSL
d03181 MMSL
004428 NDDF
004429 NDDF
108432009 SNOMEDCT_US
108434005 SNOMEDCT_US
372490001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0833 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 35 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0836 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 35 sections
Effexor XR HUMAN PRESCRIPTION DRUG LABEL 1 0008-0837 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 35 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7384 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7385 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7386 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9147 TABLET 25 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9148 TABLET 37.50 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9149 TABLET 50 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9157 TABLET 75 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9163 TABLET 100 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2604 TABLET 150 mg ORAL ANDA 29 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-2605 TABLET 225 mg ORAL ANDA 29 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0527-2606 TABLET 75 mg ORAL ANDA 29 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-6566 TABLET 37.50 mg ORAL ANDA 25 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-6567 TABLET 75 mg ORAL ANDA 23 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7557 TABLET 50 mg ORAL ANDA 23 sections
Venlafaxine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7558 TABLET 100 mg ORAL ANDA 23 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7621 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7622 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8122 TABLET 75 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8346 TABLET 75 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6468 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 31 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6469 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 31 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6470 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 31 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 13668-018 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 31 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 13668-019 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 31 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 13668-020 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 31 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13811-712 TABLET, EXTENDED RELEASE 37.50 mg ORAL NDA AUTHORIZED GENERIC 29 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13811-713 TABLET, EXTENDED RELEASE 75 mg ORAL NDA AUTHORIZED GENERIC 29 sections