Stem definition | Drug id | CAS RN |
---|---|---|
2813 | 93413-69-5 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 572 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4.60 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 11.59 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 45 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 4.40 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 14 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.73 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 28, 1993 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 1115.59 | 9.65 | 849 | 159333 | 26535 | 46499345 |
Completed suicide | 1115.40 | 9.65 | 1881 | 158301 | 144039 | 46381841 |
Intentional overdose | 897.65 | 9.65 | 1110 | 159072 | 63834 | 46462046 |
Suicide attempt | 762.54 | 9.65 | 942 | 159240 | 54094 | 46471786 |
Suicidal ideation | 741.21 | 9.65 | 940 | 159242 | 55442 | 46470438 |
Serotonin syndrome | 724.13 | 9.65 | 627 | 159555 | 23593 | 46502287 |
Toxicity to various agents | 594.55 | 9.65 | 1834 | 158348 | 209932 | 46315948 |
Depression | 567.31 | 9.65 | 1567 | 158615 | 168537 | 46357343 |
Intentional self-injury | 451.56 | 9.65 | 483 | 159699 | 23683 | 46502197 |
Overdose | 438.85 | 9.65 | 1035 | 159147 | 100944 | 46424936 |
Drug abuse | 385.54 | 9.65 | 741 | 159441 | 62667 | 46463213 |
Withdrawal syndrome | 364.73 | 9.65 | 377 | 159805 | 17757 | 46508123 |
Drug interaction | 355.08 | 9.65 | 1508 | 158674 | 201586 | 46324294 |
Agitation | 298.83 | 9.65 | 616 | 159566 | 54799 | 46471081 |
Rheumatoid arthritis | 291.64 | 9.65 | 238 | 159944 | 239977 | 46285903 |
Anxiety | 282.96 | 9.65 | 1305 | 158877 | 180652 | 46345228 |
Sopor | 265.71 | 9.65 | 334 | 159848 | 19494 | 46506386 |
Tremor | 238.01 | 9.65 | 904 | 159278 | 114735 | 46411145 |
Coma | 234.42 | 9.65 | 577 | 159605 | 57772 | 46468108 |
Poisoning deliberate | 222.37 | 9.65 | 198 | 159984 | 7728 | 46518152 |
Mydriasis | 218.71 | 9.65 | 223 | 159959 | 10330 | 46515550 |
Crying | 201.46 | 9.65 | 302 | 159880 | 20839 | 46505041 |
Hyperhidrosis | 186.02 | 9.65 | 701 | 159481 | 88607 | 46437273 |
Electrocardiogram QT prolonged | 176.70 | 9.65 | 479 | 159703 | 50846 | 46475034 |
Akathisia | 174.58 | 9.65 | 171 | 160011 | 7543 | 46518337 |
Joint swelling | 160.84 | 9.65 | 200 | 159982 | 165873 | 46360007 |
Depressed mood | 159.50 | 9.65 | 353 | 159829 | 32966 | 46492914 |
Seizure | 155.11 | 9.65 | 832 | 159350 | 122222 | 46403658 |
Somnolence | 154.44 | 9.65 | 992 | 159190 | 155529 | 46370351 |
Disturbance in attention | 151.79 | 9.65 | 335 | 159847 | 31225 | 46494655 |
Panic attack | 141.05 | 9.65 | 251 | 159931 | 19991 | 46505889 |
Irritability | 140.05 | 9.65 | 308 | 159874 | 28638 | 46497242 |
Contraindicated product administered | 135.98 | 9.65 | 52 | 160130 | 79895 | 46445985 |
Pneumonia | 135.22 | 9.65 | 749 | 159433 | 375571 | 46150309 |
Nightmare | 133.01 | 9.65 | 219 | 159963 | 16379 | 46509501 |
Anger | 131.48 | 9.65 | 182 | 160000 | 11670 | 46514210 |
Anaemia | 130.98 | 9.65 | 445 | 159737 | 255334 | 46270546 |
Restlessness | 127.36 | 9.65 | 275 | 159907 | 25249 | 46500631 |
Aggression | 123.90 | 9.65 | 254 | 159928 | 22490 | 46503390 |
Treatment failure | 123.37 | 9.65 | 84 | 160098 | 93003 | 46432877 |
Febrile neutropenia | 123.28 | 9.65 | 87 | 160095 | 94540 | 46431340 |
Rash | 121.89 | 9.65 | 721 | 159461 | 355791 | 46170089 |
Cardiac arrest | 117.12 | 9.65 | 616 | 159566 | 89783 | 46436097 |
Off label use | 116.61 | 9.65 | 794 | 159388 | 379047 | 46146833 |
Feeling abnormal | 114.43 | 9.65 | 778 | 159404 | 124282 | 46401598 |
Respiratory arrest | 113.77 | 9.65 | 313 | 159869 | 33503 | 46492377 |
Drug dependence | 106.93 | 9.65 | 221 | 159961 | 19680 | 46506200 |
Product substitution issue | 106.80 | 9.65 | 188 | 159994 | 14843 | 46511037 |
Confusional state | 106.76 | 9.65 | 924 | 159258 | 158968 | 46366912 |
Synovitis | 106.76 | 9.65 | 38 | 160144 | 61037 | 46464843 |
Systemic lupus erythematosus | 106.58 | 9.65 | 45 | 160137 | 65135 | 46460745 |
Sepsis | 105.28 | 9.65 | 191 | 159991 | 135823 | 46390057 |
Poisoning | 104.61 | 9.65 | 179 | 160003 | 13815 | 46512065 |
Disorientation | 102.42 | 9.65 | 319 | 159863 | 36599 | 46489281 |
Generalised tonic-clonic seizure | 100.29 | 9.65 | 260 | 159922 | 26862 | 46499018 |
Insomnia | 98.83 | 9.65 | 931 | 159251 | 163993 | 46361887 |
Pyrexia | 96.91 | 9.65 | 750 | 159432 | 348052 | 46177828 |
Psychomotor hyperactivity | 96.86 | 9.65 | 141 | 160041 | 9472 | 46516408 |
Major depression | 94.91 | 9.65 | 116 | 160066 | 6574 | 46519306 |
Tearfulness | 92.33 | 9.65 | 91 | 160091 | 4044 | 46521836 |
Diarrhoea | 91.66 | 9.65 | 1361 | 158821 | 558241 | 45967639 |
Selective eating disorder | 91.27 | 9.65 | 63 | 160119 | 1682 | 46524198 |
Dyspnoea | 91.07 | 9.65 | 1235 | 158947 | 514313 | 46011567 |
Weight increased | 89.52 | 9.65 | 910 | 159272 | 163563 | 46362317 |
Mania | 89.46 | 9.65 | 145 | 160037 | 10701 | 46515179 |
Gestational diabetes | 89.45 | 9.65 | 117 | 160065 | 7102 | 46518778 |
Platelet count decreased | 89.09 | 9.65 | 128 | 160054 | 99896 | 46425984 |
Sleep-related eating disorder | 88.47 | 9.65 | 43 | 160139 | 576 | 46525304 |
Antidepressant drug level increased | 88.34 | 9.65 | 34 | 160148 | 245 | 46525635 |
Tachycardia | 88.28 | 9.65 | 615 | 159567 | 99007 | 46426873 |
Death | 87.44 | 9.65 | 734 | 159448 | 334814 | 46191066 |
Drug withdrawal syndrome neonatal | 85.61 | 9.65 | 63 | 160119 | 1865 | 46524015 |
Infection | 85.42 | 9.65 | 209 | 159973 | 133383 | 46392497 |
Alopecia | 82.06 | 9.65 | 284 | 159898 | 162130 | 46363750 |
Arthropathy | 81.93 | 9.65 | 102 | 160080 | 84598 | 46441282 |
Infusion related reaction | 80.21 | 9.65 | 140 | 160042 | 101068 | 46424812 |
Mood swings | 79.81 | 9.65 | 174 | 160008 | 16078 | 46509802 |
Abnormal dreams | 77.52 | 9.65 | 132 | 160050 | 10147 | 46515733 |
Hand deformity | 76.92 | 9.65 | 13 | 160169 | 34561 | 46491319 |
Amnesia | 75.48 | 9.65 | 313 | 159869 | 41318 | 46484562 |
Muscle rigidity | 75.23 | 9.65 | 128 | 160054 | 9833 | 46516047 |
Thrombocytopenia | 74.07 | 9.65 | 207 | 159975 | 126374 | 46399506 |
Small for dates baby | 73.80 | 9.65 | 76 | 160106 | 3561 | 46522319 |
Neutropenia | 73.28 | 9.65 | 249 | 159933 | 142955 | 46382925 |
Paraesthesia | 71.83 | 9.65 | 666 | 159516 | 116771 | 46409109 |
Self-injurious ideation | 71.65 | 9.65 | 61 | 160121 | 2239 | 46523641 |
Cardio-respiratory arrest | 70.78 | 9.65 | 398 | 159784 | 59471 | 46466409 |
Hypersensitivity | 70.55 | 9.65 | 271 | 159911 | 150050 | 46375830 |
Thinking abnormal | 70.05 | 9.65 | 123 | 160059 | 9691 | 46516189 |
Renal impairment | 69.40 | 9.65 | 92 | 160090 | 74280 | 46451600 |
Hyperreflexia | 67.98 | 9.65 | 87 | 160095 | 5167 | 46520713 |
Sedation | 67.31 | 9.65 | 202 | 159980 | 22708 | 46503172 |
Decorticate posture | 66.94 | 9.65 | 30 | 160152 | 330 | 46525550 |
Homicide | 66.82 | 9.65 | 32 | 160150 | 414 | 46525466 |
Psychomotor retardation | 66.40 | 9.65 | 68 | 160114 | 3165 | 46522715 |
Arthralgia | 65.82 | 9.65 | 869 | 159313 | 363734 | 46162146 |
Myocardial depression | 65.80 | 9.65 | 33 | 160149 | 475 | 46525405 |
Galactorrhoea | 64.13 | 9.65 | 72 | 160110 | 3725 | 46522155 |
Atrial fibrillation | 63.92 | 9.65 | 165 | 160017 | 103425 | 46422455 |
Hallucination | 63.70 | 9.65 | 339 | 159843 | 49612 | 46476268 |
Antidepressant drug level above therapeutic | 63.38 | 9.65 | 29 | 160153 | 336 | 46525544 |
Haemoglobin decreased | 62.76 | 9.65 | 229 | 159953 | 128720 | 46397160 |
Disease progression | 62.22 | 9.65 | 138 | 160044 | 91162 | 46434718 |
Apathy | 61.08 | 9.65 | 98 | 160084 | 7170 | 46518710 |
Abdominal discomfort | 60.81 | 9.65 | 289 | 159893 | 150876 | 46375004 |
C-reactive protein abnormal | 60.42 | 9.65 | 3 | 160179 | 21267 | 46504613 |
Neuroleptic malignant syndrome | 60.32 | 9.65 | 124 | 160058 | 10998 | 46514882 |
Tardive dyskinesia | 59.72 | 9.65 | 99 | 160083 | 7444 | 46518436 |
Mental disorder | 59.65 | 9.65 | 191 | 159991 | 22234 | 46503646 |
Mental impairment | 59.62 | 9.65 | 132 | 160050 | 12324 | 46513556 |
Abnormal behaviour | 59.36 | 9.65 | 183 | 159999 | 20875 | 46505005 |
Physical assault | 59.09 | 9.65 | 39 | 160143 | 965 | 46524915 |
Malignant neoplasm progression | 58.88 | 9.65 | 82 | 160100 | 64844 | 46461036 |
Hypotonia neonatal | 58.74 | 9.65 | 37 | 160145 | 843 | 46525037 |
Pancytopenia | 58.43 | 9.65 | 128 | 160054 | 84930 | 46440950 |
Large for dates baby | 56.82 | 9.65 | 29 | 160153 | 434 | 46525446 |
Meconium in amniotic fluid | 56.64 | 9.65 | 22 | 160160 | 163 | 46525717 |
Atrial septal defect | 55.45 | 9.65 | 87 | 160095 | 6245 | 46519635 |
Pain | 55.21 | 9.65 | 1232 | 158950 | 475716 | 46050164 |
Plasma cell myeloma | 55.18 | 9.65 | 43 | 160139 | 44435 | 46481445 |
Acute kidney injury | 55.18 | 9.65 | 530 | 159652 | 235325 | 46290555 |
Drug screen false positive | 53.89 | 9.65 | 35 | 160147 | 842 | 46525038 |
Peripheral swelling | 53.68 | 9.65 | 320 | 159862 | 157751 | 46368129 |
Glossodynia | 53.67 | 9.65 | 44 | 160138 | 44329 | 46481551 |
Intentional product misuse | 53.53 | 9.65 | 310 | 159872 | 46818 | 46479062 |
Depressive symptom | 53.50 | 9.65 | 57 | 160125 | 2779 | 46523101 |
Foetal exposure during pregnancy | 53.26 | 9.65 | 228 | 159954 | 30519 | 46495361 |
Swelling | 53.07 | 9.65 | 233 | 159949 | 124278 | 46401602 |
Cough | 52.76 | 9.65 | 520 | 159662 | 229729 | 46296151 |
Bipolar disorder | 52.59 | 9.65 | 91 | 160091 | 7086 | 46518794 |
Homicidal ideation | 52.50 | 9.65 | 46 | 160136 | 1756 | 46524124 |
Extrapyramidal disorder | 52.35 | 9.65 | 118 | 160064 | 11150 | 46514730 |
Stress cardiomyopathy | 52.27 | 9.65 | 95 | 160087 | 7689 | 46518191 |
Nervousness | 51.54 | 9.65 | 214 | 159968 | 28261 | 46497619 |
Gastrointestinal haemorrhage | 51.05 | 9.65 | 119 | 160063 | 77254 | 46448626 |
Anaphylactic reaction | 50.27 | 9.65 | 65 | 160117 | 53047 | 46472833 |
Neonatal hypoxia | 50.06 | 9.65 | 27 | 160155 | 455 | 46525425 |
Psychotic disorder | 49.91 | 9.65 | 181 | 160001 | 22440 | 46503440 |
Product residue present | 49.79 | 9.65 | 64 | 160118 | 3818 | 46522062 |
Drug intolerance | 49.23 | 9.65 | 299 | 159883 | 146750 | 46379130 |
Benzodiazepine drug level increased | 49.13 | 9.65 | 20 | 160162 | 170 | 46525710 |
Impulsive behaviour | 48.88 | 9.65 | 41 | 160141 | 1474 | 46524406 |
Tinnitus | 48.54 | 9.65 | 206 | 159976 | 27467 | 46498413 |
Feeling of despair | 48.47 | 9.65 | 44 | 160138 | 1761 | 46524119 |
Herpes zoster | 48.40 | 9.65 | 100 | 160082 | 67772 | 46458108 |
Nasopharyngitis | 47.53 | 9.65 | 321 | 159861 | 153677 | 46372203 |
Cataplexy | 47.18 | 9.65 | 36 | 160146 | 1127 | 46524753 |
Dizziness | 46.43 | 9.65 | 1511 | 158671 | 338903 | 46186977 |
Opsoclonus myoclonus | 46.38 | 9.65 | 18 | 160164 | 133 | 46525747 |
Suicidal behaviour | 45.83 | 9.65 | 49 | 160133 | 2399 | 46523481 |
Fluid retention | 45.75 | 9.65 | 65 | 160117 | 50981 | 46474899 |
Bruxism | 45.56 | 9.65 | 54 | 160128 | 2963 | 46522917 |
Nystagmus | 45.39 | 9.65 | 75 | 160107 | 5624 | 46520256 |
Parkinsonism | 44.74 | 9.65 | 90 | 160092 | 7858 | 46518022 |
Muscle twitching | 44.65 | 9.65 | 131 | 160051 | 14541 | 46511339 |
Pleural effusion | 44.64 | 9.65 | 141 | 160041 | 82811 | 46443069 |
Mood altered | 44.34 | 9.65 | 121 | 160061 | 12886 | 46512994 |
Personality disorder | 43.92 | 9.65 | 54 | 160128 | 3079 | 46522801 |
Somnambulism | 43.82 | 9.65 | 69 | 160113 | 4968 | 46520912 |
Hypomania | 43.68 | 9.65 | 64 | 160118 | 4324 | 46521556 |
Myoclonus | 43.54 | 9.65 | 128 | 160054 | 14224 | 46511656 |
Pain in extremity | 43.22 | 9.65 | 626 | 159556 | 258054 | 46267826 |
White blood cell count decreased | 43.13 | 9.65 | 218 | 159964 | 112013 | 46413867 |
Altered state of consciousness | 42.67 | 9.65 | 176 | 160006 | 23172 | 46502708 |
Drug hypersensitivity | 42.15 | 9.65 | 1115 | 159067 | 242710 | 46283170 |
Self esteem decreased | 41.82 | 9.65 | 25 | 160157 | 517 | 46525363 |
Hallucination, auditory | 41.71 | 9.65 | 105 | 160077 | 10651 | 46515229 |
Pericarditis | 41.61 | 9.65 | 15 | 160167 | 23912 | 46501968 |
Panic reaction | 41.44 | 9.65 | 57 | 160125 | 3632 | 46522248 |
Bezoar | 40.90 | 9.65 | 36 | 160146 | 1383 | 46524497 |
Leukopenia | 40.52 | 9.65 | 111 | 160071 | 68232 | 46457648 |
Hallucination, visual | 40.27 | 9.65 | 144 | 160038 | 17729 | 46508151 |
Injection site pain | 40.12 | 9.65 | 210 | 159972 | 106942 | 46418938 |
Foetal death | 40.00 | 9.65 | 91 | 160091 | 8652 | 46517228 |
Respiratory depression | 39.63 | 9.65 | 108 | 160074 | 11492 | 46514388 |
Vertigo | 39.61 | 9.65 | 310 | 159872 | 51738 | 46474142 |
Anorgasmia | 39.56 | 9.65 | 25 | 160157 | 573 | 46525307 |
Dissociation | 39.50 | 9.65 | 40 | 160142 | 1837 | 46524043 |
Neutrophil count decreased | 39.21 | 9.65 | 55 | 160127 | 43371 | 46482509 |
Erythema | 39.11 | 9.65 | 308 | 159874 | 142512 | 46383368 |
Memory impairment | 38.75 | 9.65 | 421 | 159761 | 76916 | 46448964 |
Toxic epidermal necrolysis | 38.69 | 9.65 | 14 | 160168 | 22264 | 46503616 |
Mucosal inflammation | 38.66 | 9.65 | 46 | 160136 | 38930 | 46486950 |
Transient tachypnoea of the newborn | 38.63 | 9.65 | 15 | 160167 | 111 | 46525769 |
Paranoia | 38.56 | 9.65 | 101 | 160081 | 10496 | 46515384 |
Libido decreased | 38.31 | 9.65 | 46 | 160136 | 2559 | 46523321 |
Inappropriate affect | 38.25 | 9.65 | 28 | 160154 | 822 | 46525058 |
Euphoric mood | 37.83 | 9.65 | 59 | 160123 | 4213 | 46521667 |
Restless legs syndrome | 37.73 | 9.65 | 130 | 160052 | 15713 | 46510167 |
Bone marrow failure | 37.67 | 9.65 | 28 | 160154 | 29641 | 46496239 |
Emotional disorder | 37.47 | 9.65 | 110 | 160072 | 12214 | 46513666 |
Renal papillary necrosis | 37.31 | 9.65 | 18 | 160164 | 237 | 46525643 |
Hypothermia | 37.29 | 9.65 | 109 | 160073 | 12074 | 46513806 |
Anticholinergic syndrome | 37.12 | 9.65 | 38 | 160144 | 1768 | 46524112 |
Migraine | 36.86 | 9.65 | 385 | 159797 | 69641 | 46456239 |
Hot flush | 36.39 | 9.65 | 265 | 159917 | 43252 | 46482628 |
Electrocardiogram QRS complex prolonged | 35.95 | 9.65 | 66 | 160116 | 5383 | 46520497 |
Amniorrhexis | 35.87 | 9.65 | 10 | 160172 | 20 | 46525860 |
Agitation neonatal | 35.64 | 9.65 | 22 | 160160 | 483 | 46525397 |
Hospitalisation | 35.34 | 9.65 | 106 | 160076 | 63279 | 46462601 |
Lung disorder | 35.11 | 9.65 | 59 | 160123 | 43245 | 46482635 |
Blood creatinine increased | 35.01 | 9.65 | 139 | 160043 | 76264 | 46449616 |
Injection site erythema | 35.00 | 9.65 | 134 | 160048 | 74293 | 46451587 |
Rapid eye movement sleep behaviour disorder | 34.72 | 9.65 | 15 | 160167 | 150 | 46525730 |
Congenital hearing disorder | 34.52 | 9.65 | 9 | 160173 | 12 | 46525868 |
Psychotic symptom | 34.37 | 9.65 | 27 | 160155 | 883 | 46524997 |
Bradycardia neonatal | 33.88 | 9.65 | 23 | 160159 | 597 | 46525283 |
Total lung capacity increased | 33.71 | 9.65 | 25 | 160157 | 749 | 46525131 |
Mobility decreased | 33.30 | 9.65 | 102 | 160080 | 60492 | 46465388 |
Loss of consciousness | 32.87 | 9.65 | 538 | 159644 | 107700 | 46418180 |
Hypersomnia | 32.77 | 9.65 | 122 | 160060 | 15317 | 46510563 |
Adjustment disorder with mixed anxiety and depressed mood | 32.76 | 9.65 | 12 | 160170 | 74 | 46525806 |
VACTERL syndrome | 32.62 | 9.65 | 9 | 160173 | 17 | 46525863 |
Hostility | 32.33 | 9.65 | 31 | 160151 | 1331 | 46524549 |
Negative thoughts | 32.29 | 9.65 | 25 | 160157 | 800 | 46525080 |
Brain death | 32.29 | 9.65 | 44 | 160138 | 2779 | 46523101 |
Coma scale abnormal | 32.23 | 9.65 | 60 | 160122 | 4946 | 46520934 |
Emotional poverty | 32.19 | 9.65 | 17 | 160165 | 274 | 46525606 |
Social avoidant behaviour | 32.09 | 9.65 | 44 | 160138 | 2795 | 46523085 |
Stomatitis | 32.09 | 9.65 | 123 | 160059 | 68174 | 46457706 |
Urinary incontinence | 31.96 | 9.65 | 187 | 159995 | 28343 | 46497537 |
Accommodation disorder | 31.70 | 9.65 | 18 | 160164 | 337 | 46525543 |
Urinary tract infection | 31.42 | 9.65 | 549 | 159633 | 219717 | 46306163 |
Neonatal respiratory distress syndrome | 31.30 | 9.65 | 41 | 160141 | 2492 | 46523388 |
Neuropathy peripheral | 30.83 | 9.65 | 184 | 159998 | 90709 | 46435171 |
Loss of libido | 30.70 | 9.65 | 30 | 160152 | 1319 | 46524561 |
Ascites | 30.45 | 9.65 | 49 | 160133 | 36535 | 46489345 |
Oedema | 30.11 | 9.65 | 123 | 160059 | 66948 | 46458932 |
Rhinorrhoea | 30.10 | 9.65 | 75 | 160107 | 47590 | 46478290 |
Respiratory failure | 29.55 | 9.65 | 197 | 159985 | 94619 | 46431261 |
Hyperprolactinaemia | 29.53 | 9.65 | 43 | 160139 | 2889 | 46522991 |
Bipolar II disorder | 29.49 | 9.65 | 16 | 160166 | 273 | 46525607 |
Delusion | 29.48 | 9.65 | 95 | 160087 | 11093 | 46514787 |
Dyskinesia | 29.48 | 9.65 | 185 | 159997 | 28740 | 46497140 |
Panic disorder | 29.42 | 9.65 | 40 | 160142 | 2521 | 46523359 |
Product use issue | 29.32 | 9.65 | 197 | 159985 | 94447 | 46431433 |
Burnout syndrome | 29.11 | 9.65 | 14 | 160168 | 183 | 46525697 |
Vitamin K decreased | 29.03 | 9.65 | 8 | 160174 | 15 | 46525865 |
Logorrhoea | 28.86 | 9.65 | 38 | 160144 | 2321 | 46523559 |
Haemangioma congenital | 28.76 | 9.65 | 19 | 160163 | 471 | 46525409 |
Derealisation | 28.56 | 9.65 | 23 | 160159 | 780 | 46525100 |
Oropharyngeal pain | 28.52 | 9.65 | 144 | 160038 | 74024 | 46451856 |
Asphyxia | 28.43 | 9.65 | 59 | 160123 | 5267 | 46520613 |
Sinus tachycardia | 28.33 | 9.65 | 148 | 160034 | 21501 | 46504379 |
Endolymphatic hydrops | 28.07 | 9.65 | 6 | 160176 | 0 | 46525880 |
Drug screen positive | 28.07 | 9.65 | 49 | 160133 | 3842 | 46522038 |
Sinusitis | 28.06 | 9.65 | 297 | 159885 | 129471 | 46396409 |
Knee arthroplasty | 27.96 | 9.65 | 24 | 160158 | 23641 | 46502239 |
Neonatal behavioural syndrome | 27.94 | 9.65 | 9 | 160173 | 35 | 46525845 |
Prescribed overdose | 27.78 | 9.65 | 89 | 160093 | 10360 | 46515520 |
Parkinsonism hyperpyrexia syndrome | 27.72 | 9.65 | 13 | 160169 | 160 | 46525720 |
Camptocormia | 27.70 | 9.65 | 14 | 160168 | 205 | 46525675 |
General physical health deterioration | 27.51 | 9.65 | 259 | 159923 | 115510 | 46410370 |
Foetal alcohol syndrome | 27.47 | 9.65 | 8 | 160174 | 20 | 46525860 |
Cytomegalovirus infection | 27.37 | 9.65 | 14 | 160168 | 18130 | 46507750 |
Wound | 27.30 | 9.65 | 67 | 160115 | 42735 | 46483145 |
Exposure during pregnancy | 27.20 | 9.65 | 522 | 159660 | 107690 | 46418190 |
Cardiac failure | 27.03 | 9.65 | 162 | 160020 | 79786 | 46446094 |
Upper respiratory tract infection | 27.02 | 9.65 | 119 | 160063 | 63437 | 46462443 |
Congenital absence of bile ducts | 26.99 | 9.65 | 9 | 160173 | 40 | 46525840 |
Feeling jittery | 26.80 | 9.65 | 91 | 160091 | 10917 | 46514963 |
Affect lability | 26.73 | 9.65 | 74 | 160108 | 7946 | 46517934 |
C-reactive protein increased | 26.58 | 9.65 | 107 | 160075 | 58483 | 46467397 |
Abulia | 26.51 | 9.65 | 16 | 160166 | 337 | 46525543 |
Psoriatic arthropathy | 26.44 | 9.65 | 53 | 160129 | 36326 | 46489554 |
Sleep disorder | 26.40 | 9.65 | 261 | 159921 | 46534 | 46479346 |
Back pain | 26.39 | 9.65 | 535 | 159647 | 209504 | 46316376 |
Delirium | 26.29 | 9.65 | 218 | 159964 | 37010 | 46488870 |
Renal failure | 26.20 | 9.65 | 256 | 159926 | 113338 | 46412542 |
Tachyphrenia | 26.18 | 9.65 | 27 | 160155 | 1267 | 46524613 |
Cardiac failure congestive | 25.97 | 9.65 | 196 | 159986 | 91554 | 46434326 |
Femur fracture | 25.95 | 9.65 | 55 | 160127 | 36942 | 46488938 |
Diverticulitis | 25.89 | 9.65 | 46 | 160136 | 32993 | 46492887 |
Musculoskeletal stiffness | 25.58 | 9.65 | 214 | 159968 | 97779 | 46428101 |
Septic shock | 25.47 | 9.65 | 107 | 160075 | 57786 | 46468094 |
Antipsychotic drug level increased | 25.41 | 9.65 | 42 | 160140 | 3150 | 46522730 |
Disturbance in sexual arousal | 25.19 | 9.65 | 10 | 160172 | 79 | 46525801 |
Hepatic function abnormal | 25.14 | 9.65 | 50 | 160132 | 34371 | 46491509 |
Red blood cell sedimentation rate increased | 24.93 | 9.65 | 25 | 160157 | 22864 | 46503016 |
Pleurothotonus | 24.83 | 9.65 | 25 | 160157 | 1140 | 46524740 |
Encephalopathy neonatal | 24.78 | 9.65 | 7 | 160175 | 15 | 46525865 |
Pyramidal tract syndrome | 24.72 | 9.65 | 15 | 160167 | 319 | 46525561 |
Helplessness | 24.70 | 9.65 | 13 | 160169 | 208 | 46525672 |
Hyperkalaemia | 24.68 | 9.65 | 90 | 160092 | 50619 | 46475261 |
Cold sweat | 24.50 | 9.65 | 88 | 160094 | 10857 | 46515023 |
Hip arthroplasty | 24.44 | 9.65 | 16 | 160166 | 18096 | 46507784 |
Frustration tolerance decreased | 24.36 | 9.65 | 55 | 160127 | 5202 | 46520678 |
Psychiatric symptom | 24.22 | 9.65 | 50 | 160132 | 4447 | 46521433 |
Hypocalcaemia | 24.10 | 9.65 | 34 | 160148 | 26751 | 46499129 |
Drug level increased | 24.08 | 9.65 | 126 | 160056 | 18315 | 46507565 |
Cerebral infarction | 23.79 | 9.65 | 27 | 160155 | 23339 | 46502541 |
Epilepsy | 23.68 | 9.65 | 151 | 160031 | 23587 | 46502293 |
Impaired work ability | 23.68 | 9.65 | 96 | 160086 | 12540 | 46513340 |
Tic | 23.60 | 9.65 | 25 | 160157 | 1211 | 46524669 |
Productive cough | 23.40 | 9.65 | 92 | 160090 | 50623 | 46475257 |
Unemployment | 23.39 | 9.65 | 5 | 160177 | 0 | 46525880 |
Peritonitis | 23.28 | 9.65 | 22 | 160160 | 20692 | 46505188 |
Electrocardiogram ST-T segment abnormal | 22.96 | 9.65 | 13 | 160169 | 242 | 46525638 |
Depressed level of consciousness | 22.93 | 9.65 | 257 | 159925 | 47312 | 46478568 |
Deja vu | 22.87 | 9.65 | 7 | 160175 | 22 | 46525858 |
Device expulsion | 22.82 | 9.65 | 37 | 160145 | 27505 | 46498375 |
Impaired driving ability | 22.79 | 9.65 | 47 | 160135 | 4177 | 46521703 |
Obsessive thoughts | 22.79 | 9.65 | 17 | 160165 | 514 | 46525366 |
Hyperacusis | 22.77 | 9.65 | 30 | 160152 | 1834 | 46524046 |
Congenital pulmonary hypertension | 22.69 | 9.65 | 9 | 160173 | 71 | 46525809 |
Acquired amegakaryocytic thrombocytopenia | 22.60 | 9.65 | 6 | 160176 | 9 | 46525871 |
Eosinophilic pustular folliculitis | 22.41 | 9.65 | 7 | 160175 | 24 | 46525856 |
Asthenia | 22.15 | 9.65 | 858 | 159324 | 310217 | 46215663 |
Drug ineffective | 22.05 | 9.65 | 2015 | 158167 | 675823 | 45850057 |
Speech disorder | 22.02 | 9.65 | 205 | 159977 | 35962 | 46489918 |
Discomfort | 21.95 | 9.65 | 84 | 160098 | 46586 | 46479294 |
Ventricular septal defect | 21.90 | 9.65 | 45 | 160137 | 3989 | 46521891 |
Antisocial behaviour | 21.90 | 9.65 | 12 | 160170 | 209 | 46525671 |
Respiratory disorder neonatal | 21.80 | 9.65 | 21 | 160161 | 907 | 46524973 |
Therapeutic product effect decreased | 21.73 | 9.65 | 180 | 160002 | 82421 | 46443459 |
Abnormal weight gain | 21.57 | 9.65 | 26 | 160156 | 1452 | 46524428 |
Dystonia | 21.47 | 9.65 | 86 | 160096 | 11171 | 46514709 |
Central nervous system necrosis | 21.40 | 9.65 | 10 | 160172 | 122 | 46525758 |
Blood catecholamines increased | 21.39 | 9.65 | 7 | 160175 | 29 | 46525851 |
Coma acidotic | 21.26 | 9.65 | 10 | 160172 | 124 | 46525756 |
Oedema peripheral | 21.20 | 9.65 | 403 | 159779 | 159303 | 46366577 |
Platelet aggregation abnormal | 21.05 | 9.65 | 5 | 160177 | 3 | 46525877 |
Helicobacter infection | 21.02 | 9.65 | 7 | 160175 | 11729 | 46514151 |
Erythema dyschromicum perstans | 20.98 | 9.65 | 8 | 160174 | 56 | 46525824 |
Cognitive disorder | 20.94 | 9.65 | 206 | 159976 | 36677 | 46489203 |
Patent ductus arteriosus | 20.87 | 9.65 | 43 | 160139 | 3819 | 46522061 |
Type 2 diabetes mellitus | 20.81 | 9.65 | 128 | 160054 | 19747 | 46506133 |
Cardiogenic shock | 20.74 | 9.65 | 111 | 160071 | 16273 | 46509607 |
Neonatal seizure | 20.42 | 9.65 | 13 | 160169 | 302 | 46525578 |
Pulmonary arterial hypertension | 20.40 | 9.65 | 36 | 160146 | 25892 | 46499988 |
Drug eruption | 20.28 | 9.65 | 26 | 160156 | 21303 | 46504577 |
Persistent depressive disorder | 20.27 | 9.65 | 21 | 160161 | 991 | 46524889 |
Social anxiety disorder | 20.24 | 9.65 | 14 | 160168 | 375 | 46525505 |
Torsade de pointes | 20.18 | 9.65 | 89 | 160093 | 12065 | 46513815 |
Neonatal tachypnoea | 20.18 | 9.65 | 8 | 160174 | 63 | 46525817 |
Dyssomnia | 20.17 | 9.65 | 7 | 160175 | 36 | 46525844 |
Trunk injury | 20.07 | 9.65 | 6 | 160176 | 17 | 46525863 |
Bone erosion | 20.04 | 9.65 | 4 | 160178 | 9439 | 46516441 |
Cellulitis | 19.96 | 9.65 | 150 | 160032 | 70138 | 46455742 |
Starvation ketoacidosis | 19.86 | 9.65 | 8 | 160174 | 66 | 46525814 |
Peritonitis bacterial | 19.82 | 9.65 | 3 | 160179 | 8650 | 46517230 |
Upper gastrointestinal haemorrhage | 19.74 | 9.65 | 17 | 160165 | 16721 | 46509159 |
Yawning | 19.68 | 9.65 | 19 | 160163 | 823 | 46525057 |
Enuresis | 19.66 | 9.65 | 29 | 160153 | 1971 | 46523909 |
Arthritis | 19.66 | 9.65 | 170 | 160012 | 77146 | 46448734 |
Neonatal disorder | 19.60 | 9.65 | 17 | 160165 | 640 | 46525240 |
Right ventricular failure | 19.40 | 9.65 | 16 | 160166 | 16077 | 46509803 |
Violence-related symptom | 19.36 | 9.65 | 14 | 160168 | 403 | 46525477 |
Skin maceration | 19.27 | 9.65 | 7 | 160175 | 42 | 46525838 |
Product dose omission issue | 19.19 | 9.65 | 436 | 159746 | 168084 | 46357796 |
Drug use disorder | 19.16 | 9.65 | 34 | 160148 | 2701 | 46523179 |
Persistent left superior vena cava | 19.13 | 9.65 | 7 | 160175 | 43 | 46525837 |
Hyperbilirubinaemia neonatal | 19.10 | 9.65 | 13 | 160169 | 339 | 46525541 |
Dysphoria | 19.07 | 9.65 | 46 | 160136 | 4543 | 46521337 |
Bradypnoea | 19.04 | 9.65 | 36 | 160146 | 3003 | 46522877 |
Dependence | 18.98 | 9.65 | 28 | 160154 | 1903 | 46523977 |
Congenital tricuspid valve incompetence | 18.97 | 9.65 | 8 | 160174 | 75 | 46525805 |
Vasoplegia syndrome | 18.94 | 9.65 | 21 | 160161 | 1071 | 46524809 |
Congenital uterine anomaly | 18.89 | 9.65 | 9 | 160173 | 115 | 46525765 |
Epistaxis | 18.85 | 9.65 | 136 | 160046 | 64169 | 46461711 |
Transfusion | 18.81 | 9.65 | 11 | 160171 | 13220 | 46512660 |
Rheumatoid nodule | 18.77 | 9.65 | 4 | 160178 | 9016 | 46516864 |
Atypical fibroxanthoma | 18.71 | 9.65 | 4 | 160178 | 0 | 46525880 |
Distributive shock | 18.70 | 9.65 | 15 | 160167 | 506 | 46525374 |
Pneumonia aspiration | 18.67 | 9.65 | 178 | 160004 | 31427 | 46494453 |
CYP3A4 polymorphism | 18.52 | 9.65 | 8 | 160174 | 80 | 46525800 |
Therapeutic product effect incomplete | 18.49 | 9.65 | 175 | 160007 | 77978 | 46447902 |
Palmar-plantar erythrodysaesthesia syndrome | 18.36 | 9.65 | 26 | 160156 | 20425 | 46505455 |
Floppy infant | 18.35 | 9.65 | 8 | 160174 | 82 | 46525798 |
Tongue biting | 18.30 | 9.65 | 23 | 160159 | 1341 | 46524539 |
Hypotonia | 18.28 | 9.65 | 66 | 160116 | 8163 | 46517717 |
Abdominal pain | 18.27 | 9.65 | 626 | 159556 | 229405 | 46296475 |
Osteonecrosis of jaw | 18.13 | 9.65 | 59 | 160123 | 34343 | 46491537 |
Intestinal strangulation | 17.85 | 9.65 | 8 | 160174 | 88 | 46525792 |
Tension | 17.80 | 9.65 | 34 | 160148 | 2858 | 46523022 |
Metabolic syndrome | 17.79 | 9.65 | 22 | 160160 | 1262 | 46524618 |
Hypnopompic hallucination | 17.76 | 9.65 | 6 | 160176 | 28 | 46525852 |
Thrombosis | 17.71 | 9.65 | 116 | 160066 | 55953 | 46469927 |
Bundle branch block right | 17.61 | 9.65 | 46 | 160136 | 4773 | 46521107 |
Merycism | 17.56 | 9.65 | 9 | 160173 | 136 | 46525744 |
Skin necrosis | 17.53 | 9.65 | 4 | 160178 | 8600 | 46517280 |
Acute myeloid leukaemia | 17.45 | 9.65 | 17 | 160165 | 15761 | 46510119 |
Encephalopathy | 17.35 | 9.65 | 184 | 159998 | 33405 | 46492475 |
Feeling guilty | 17.28 | 9.65 | 14 | 160168 | 479 | 46525401 |
Libido increased | 17.25 | 9.65 | 17 | 160165 | 755 | 46525125 |
Bacteraemia | 17.22 | 9.65 | 14 | 160168 | 14165 | 46511715 |
No adverse event | 17.16 | 9.65 | 60 | 160122 | 34171 | 46491709 |
Schizophreniform disorder | 17.14 | 9.65 | 7 | 160175 | 60 | 46525820 |
Tonic convulsion | 17.04 | 9.65 | 20 | 160162 | 1086 | 46524794 |
Fluid overload | 16.99 | 9.65 | 43 | 160139 | 27142 | 46498738 |
Flight of ideas | 16.89 | 9.65 | 12 | 160170 | 336 | 46525544 |
Interstitial lung disease | 16.85 | 9.65 | 112 | 160070 | 53837 | 46472043 |
Psychiatric decompensation | 16.79 | 9.65 | 20 | 160162 | 1103 | 46524777 |
Eye movement disorder | 16.75 | 9.65 | 45 | 160137 | 4748 | 46521132 |
Tremor neonatal | 16.67 | 9.65 | 8 | 160174 | 104 | 46525776 |
Attention deficit hyperactivity disorder | 16.52 | 9.65 | 28 | 160154 | 2144 | 46523736 |
Bronchitis | 16.44 | 9.65 | 260 | 159922 | 105719 | 46420161 |
Cataract | 16.43 | 9.65 | 90 | 160092 | 45325 | 46480555 |
Sluggishness | 16.35 | 9.65 | 44 | 160138 | 4647 | 46521233 |
Drug abuser | 16.31 | 9.65 | 35 | 160147 | 3198 | 46522682 |
Language disorder | 16.31 | 9.65 | 23 | 160159 | 1500 | 46524380 |
COVID-19 | 16.30 | 9.65 | 24 | 160158 | 18551 | 46507329 |
Post-traumatic stress disorder | 16.20 | 9.65 | 40 | 160142 | 4008 | 46521872 |
Respiratory tract inflammation | 16.12 | 9.65 | 13 | 160169 | 442 | 46525438 |
Transient psychosis | 16.11 | 9.65 | 6 | 160176 | 39 | 46525841 |
Wheezing | 16.09 | 9.65 | 112 | 160070 | 53274 | 46472606 |
Feelings of worthlessness | 16.09 | 9.65 | 11 | 160171 | 289 | 46525591 |
Bipolar I disorder | 16.05 | 9.65 | 23 | 160159 | 1523 | 46524357 |
Dysarthria | 16.03 | 9.65 | 198 | 159984 | 37300 | 46488580 |
Executive dysfunction | 16.02 | 9.65 | 8 | 160174 | 114 | 46525766 |
Electroencephalogram abnormal | 15.99 | 9.65 | 38 | 160144 | 3716 | 46522164 |
Anal atresia | 15.97 | 9.65 | 12 | 160170 | 367 | 46525513 |
Nodule | 15.92 | 9.65 | 18 | 160164 | 15587 | 46510293 |
Coarctation of the aorta | 15.92 | 9.65 | 14 | 160168 | 537 | 46525343 |
Chronic kidney disease | 15.91 | 9.65 | 79 | 160103 | 40792 | 46485088 |
Female sexual dysfunction | 15.86 | 9.65 | 6 | 160176 | 41 | 46525839 |
Marchiafava-Bignami disease | 15.82 | 9.65 | 5 | 160177 | 18 | 46525862 |
False positive investigation result | 15.81 | 9.65 | 14 | 160168 | 542 | 46525338 |
Neurological examination abnormal | 15.79 | 9.65 | 10 | 160172 | 230 | 46525650 |
Splenic infarction | 15.75 | 9.65 | 23 | 160159 | 1549 | 46524331 |
Rhabdomyolysis | 15.70 | 9.65 | 216 | 159966 | 41693 | 46484187 |
Affective disorder | 15.63 | 9.65 | 44 | 160138 | 4771 | 46521109 |
Congestive cardiomyopathy | 15.50 | 9.65 | 49 | 160133 | 5664 | 46520216 |
Facial nerve disorder | 15.49 | 9.65 | 14 | 160168 | 557 | 46525323 |
Tumour lysis syndrome | 15.49 | 9.65 | 3 | 160179 | 7233 | 46518647 |
Consciousness fluctuating | 15.41 | 9.65 | 14 | 160168 | 561 | 46525319 |
Respiratory tract infection | 15.39 | 9.65 | 52 | 160130 | 29920 | 46495960 |
Alcohol interaction | 15.36 | 9.65 | 29 | 160153 | 2416 | 46523464 |
Infantile apnoea | 15.36 | 9.65 | 16 | 160166 | 760 | 46525120 |
Acute myocardial infarction | 15.31 | 9.65 | 57 | 160125 | 31867 | 46494013 |
Sciatic nerve neuropathy | 15.26 | 9.65 | 11 | 160171 | 315 | 46525565 |
Subendocardial ischaemia | 15.23 | 9.65 | 7 | 160175 | 82 | 46525798 |
Cogwheel rigidity | 15.22 | 9.65 | 22 | 160160 | 1468 | 46524412 |
Postmortem blood drug level abnormal | 15.20 | 9.65 | 11 | 160171 | 317 | 46525563 |
Neutropenic sepsis | 15.17 | 9.65 | 12 | 160170 | 12312 | 46513568 |
Blood urea increased | 15.15 | 9.65 | 41 | 160141 | 25311 | 46500569 |
Transplant rejection | 15.09 | 9.65 | 7 | 160175 | 9589 | 46516291 |
Melaena | 15.08 | 9.65 | 47 | 160135 | 27725 | 46498155 |
Cytopenia | 15.07 | 9.65 | 4 | 160178 | 7764 | 46518116 |
Anticonvulsant drug level above therapeutic | 15.07 | 9.65 | 13 | 160169 | 486 | 46525394 |
Device related infection | 14.99 | 9.65 | 31 | 160151 | 21010 | 46504870 |
Forced expiratory volume decreased | 14.98 | 9.65 | 45 | 160137 | 5059 | 46520821 |
Clonus | 14.96 | 9.65 | 39 | 160143 | 4041 | 46521839 |
Throat irritation | 14.93 | 9.65 | 50 | 160132 | 28851 | 46497029 |
Inappropriate antidiuretic hormone secretion | 14.87 | 9.65 | 91 | 160091 | 14011 | 46511869 |
Hyponatraemia | 14.85 | 9.65 | 454 | 159728 | 100878 | 46425002 |
Poor personal hygiene | 14.85 | 9.65 | 11 | 160171 | 329 | 46525551 |
Thrombotic microangiopathy | 14.80 | 9.65 | 5 | 160177 | 8301 | 46517579 |
Depression suicidal | 14.77 | 9.65 | 22 | 160160 | 1508 | 46524372 |
Immunodeficiency | 14.63 | 9.65 | 14 | 160168 | 13092 | 46512788 |
Pruritus | 14.60 | 9.65 | 681 | 159501 | 241671 | 46284209 |
Neoplasm progression | 14.60 | 9.65 | 45 | 160137 | 26638 | 46499242 |
Poverty of speech | 14.58 | 9.65 | 10 | 160172 | 264 | 46525616 |
Ventricular tachycardia | 14.57 | 9.65 | 104 | 160078 | 16863 | 46509017 |
Blood bilirubin increased | 14.53 | 9.65 | 64 | 160118 | 34120 | 46491760 |
Right ventricular systolic pressure decreased | 14.52 | 9.65 | 5 | 160177 | 25 | 46525855 |
Dry mouth | 14.50 | 9.65 | 267 | 159915 | 54659 | 46471221 |
Nasal congestion | 14.47 | 9.65 | 101 | 160081 | 48012 | 46477868 |
Persecutory delusion | 14.46 | 9.65 | 29 | 160153 | 2526 | 46523354 |
Labour complication | 14.45 | 9.65 | 7 | 160175 | 93 | 46525787 |
Coordination abnormal | 14.42 | 9.65 | 75 | 160107 | 10874 | 46515006 |
Injection site bruising | 14.38 | 9.65 | 68 | 160114 | 35568 | 46490312 |
Febrile bone marrow aplasia | 14.36 | 9.65 | 3 | 160179 | 6859 | 46519021 |
Cystic lymphangioma | 14.36 | 9.65 | 5 | 160177 | 26 | 46525854 |
Phagophobia | 14.36 | 9.65 | 5 | 160177 | 26 | 46525854 |
Hypokalaemia | 14.32 | 9.65 | 214 | 159968 | 87810 | 46438070 |
Injection site rash | 14.30 | 9.65 | 20 | 160162 | 15793 | 46510087 |
Nonspecific reaction | 14.27 | 9.65 | 24 | 160158 | 1826 | 46524054 |
Oxygen saturation decreased | 14.26 | 9.65 | 160 | 160022 | 69004 | 46456876 |
Peak expiratory flow rate decreased | 14.22 | 9.65 | 14 | 160168 | 621 | 46525259 |
Alcohol use | 14.16 | 9.65 | 28 | 160154 | 2414 | 46523466 |
Epstein-Barr virus infection | 14.13 | 9.65 | 3 | 160179 | 6781 | 46519099 |
Parachute mitral valve | 14.13 | 9.65 | 7 | 160175 | 98 | 46525782 |
Feeling drunk | 14.09 | 9.65 | 37 | 160145 | 3850 | 46522030 |
CYP2D6 polymorphism | 14.04 | 9.65 | 3 | 160179 | 0 | 46525880 |
Corneal cyst | 14.04 | 9.65 | 3 | 160179 | 0 | 46525880 |
Muscle tone disorder | 14.00 | 9.65 | 7 | 160175 | 100 | 46525780 |
Skin discolouration | 14.00 | 9.65 | 61 | 160121 | 32619 | 46493261 |
Metastases to bone | 13.99 | 9.65 | 24 | 160158 | 17452 | 46508428 |
Lung diffusion test decreased | 13.99 | 9.65 | 14 | 160168 | 634 | 46525246 |
Infective pulmonary exacerbation of cystic fibrosis | 13.98 | 9.65 | 10 | 160172 | 10797 | 46515083 |
Proteinuria | 13.93 | 9.65 | 22 | 160160 | 16531 | 46509349 |
Tympanic membrane disorder | 13.89 | 9.65 | 8 | 160174 | 154 | 46525726 |
Iodine allergy | 13.86 | 9.65 | 13 | 160169 | 543 | 46525337 |
Perinatal depression | 13.82 | 9.65 | 13 | 160169 | 545 | 46525335 |
Impaired healing | 13.75 | 9.65 | 72 | 160110 | 36671 | 46489209 |
Divorced | 13.74 | 9.65 | 4 | 160178 | 10 | 46525870 |
Slow speech | 13.73 | 9.65 | 20 | 160162 | 1344 | 46524536 |
Electrocardiogram QRS complex shortened | 13.71 | 9.65 | 11 | 160171 | 371 | 46525509 |
Foetal arrhythmia | 13.71 | 9.65 | 8 | 160174 | 158 | 46525722 |
Neonatal asphyxia | 13.70 | 9.65 | 9 | 160173 | 221 | 46525659 |
Somatic symptom disorder | 13.69 | 9.65 | 24 | 160158 | 1888 | 46523992 |
Rhythm idioventricular | 13.66 | 9.65 | 8 | 160174 | 159 | 46525721 |
Pre-eclampsia | 13.62 | 9.65 | 59 | 160123 | 7935 | 46517945 |
Mechanical urticaria | 13.61 | 9.65 | 11 | 160171 | 375 | 46525505 |
Liver function test increased | 13.58 | 9.65 | 37 | 160145 | 22789 | 46503091 |
Dialysis | 13.56 | 9.65 | 9 | 160173 | 10107 | 46515773 |
Alcoholism | 13.56 | 9.65 | 26 | 160156 | 2192 | 46523688 |
Death neonatal | 13.55 | 9.65 | 9 | 160173 | 225 | 46525655 |
Pulmonary artery stenosis congenital | 13.55 | 9.65 | 9 | 160173 | 225 | 46525655 |
Haematocrit decreased | 13.51 | 9.65 | 68 | 160114 | 34989 | 46490891 |
Renal injury | 13.47 | 9.65 | 8 | 160174 | 9533 | 46516347 |
Cholestatic liver injury | 13.39 | 9.65 | 25 | 160157 | 2065 | 46523815 |
Hypercalcaemia | 13.37 | 9.65 | 33 | 160149 | 21013 | 46504867 |
Cold agglutinins positive | 13.36 | 9.65 | 5 | 160177 | 33 | 46525847 |
Cardiotoxicity | 13.34 | 9.65 | 52 | 160130 | 6670 | 46519210 |
Drug level above therapeutic | 13.34 | 9.65 | 34 | 160148 | 3475 | 46522405 |
Sexual dysfunction | 13.28 | 9.65 | 27 | 160155 | 2376 | 46523504 |
Hypertonia neonatal | 13.25 | 9.65 | 9 | 160173 | 234 | 46525646 |
Ligament pain | 13.19 | 9.65 | 8 | 160174 | 170 | 46525710 |
Movement disorder | 13.17 | 9.65 | 101 | 160081 | 16748 | 46509132 |
Dropped head syndrome | 13.14 | 9.65 | 7 | 160175 | 115 | 46525765 |
Basal cell carcinoma | 13.12 | 9.65 | 32 | 160150 | 20455 | 46505425 |
Myelosuppression | 13.11 | 9.65 | 5 | 160177 | 7698 | 46518182 |
Asthma | 13.08 | 9.65 | 228 | 159954 | 91314 | 46434566 |
Conversion disorder | 13.06 | 9.65 | 22 | 160160 | 1676 | 46524204 |
Acute hepatitis B | 13.05 | 9.65 | 10 | 160172 | 315 | 46525565 |
Dyspnoea exertional | 13.04 | 9.65 | 110 | 160072 | 50179 | 46475701 |
Marital problem | 13.03 | 9.65 | 8 | 160174 | 174 | 46525706 |
Blood creatine phosphokinase increased | 13 | 9.65 | 149 | 160033 | 27575 | 46498305 |
Colitis | 12.98 | 9.65 | 75 | 160107 | 37272 | 46488608 |
Feeling of body temperature change | 12.97 | 9.65 | 38 | 160144 | 4214 | 46521666 |
Palpitations | 12.96 | 9.65 | 423 | 159759 | 94836 | 46431044 |
Premature delivery | 12.96 | 9.65 | 36 | 160146 | 22033 | 46503847 |
Device issue | 12.96 | 9.65 | 31 | 160151 | 19949 | 46505931 |
Spine malformation | 12.95 | 9.65 | 9 | 160173 | 243 | 46525637 |
Loose tooth | 12.93 | 9.65 | 32 | 160150 | 3212 | 46522668 |
Adverse drug reaction | 12.92 | 9.65 | 94 | 160088 | 44268 | 46481612 |
Chest discomfort | 12.84 | 9.65 | 225 | 159957 | 90044 | 46435836 |
Pneumonitis | 12.82 | 9.65 | 52 | 160130 | 28368 | 46497512 |
Nervous system disorder | 12.78 | 9.65 | 97 | 160085 | 16032 | 46509848 |
Barotrauma | 12.67 | 9.65 | 8 | 160174 | 183 | 46525697 |
Pulmonary hypertension | 12.66 | 9.65 | 72 | 160110 | 35921 | 46489959 |
Musculoskeletal pain | 12.64 | 9.65 | 167 | 160015 | 69961 | 46455919 |
Tuberculosis | 12.63 | 9.65 | 10 | 160172 | 10255 | 46515625 |
Apallic syndrome | 12.61 | 9.65 | 13 | 160169 | 610 | 46525270 |
Tenosynovitis | 12.58 | 9.65 | 5 | 160177 | 7510 | 46518370 |
Complication associated with device | 12.55 | 9.65 | 21 | 160161 | 15420 | 46510460 |
Hereditary non-polyposis colorectal cancer syndrome | 12.52 | 9.65 | 7 | 160175 | 127 | 46525753 |
Incoherent | 12.52 | 9.65 | 39 | 160143 | 4473 | 46521407 |
Sleep talking | 12.49 | 9.65 | 16 | 160166 | 951 | 46524929 |
Device dislocation | 12.48 | 9.65 | 36 | 160146 | 21766 | 46504114 |
Respiration abnormal | 12.47 | 9.65 | 39 | 160143 | 4482 | 46521398 |
Ocular hyperaemia | 12.45 | 9.65 | 31 | 160151 | 19679 | 46506201 |
Personality change | 12.39 | 9.65 | 43 | 160139 | 5215 | 46520665 |
Brief psychotic disorder with marked stressors | 12.37 | 9.65 | 6 | 160176 | 80 | 46525800 |
Abnormal sleep-related event | 12.33 | 9.65 | 14 | 160168 | 733 | 46525147 |
Normetanephrine urine increased | 12.33 | 9.65 | 4 | 160178 | 16 | 46525864 |
Pain in jaw | 12.32 | 9.65 | 79 | 160103 | 38293 | 46487587 |
Choreoathetosis | 12.31 | 9.65 | 11 | 160171 | 431 | 46525449 |
Anaemia of pregnancy | 12.30 | 9.65 | 6 | 160176 | 81 | 46525799 |
Hyperthermia malignant | 12.30 | 9.65 | 14 | 160168 | 735 | 46525145 |
Jaundice neonatal | 12.30 | 9.65 | 15 | 160167 | 848 | 46525032 |
Hypoalbuminaemia | 12.29 | 9.65 | 10 | 160172 | 10117 | 46515763 |
Retinal detachment | 12.27 | 9.65 | 42 | 160140 | 5058 | 46520822 |
Myelodysplastic syndrome | 12.19 | 9.65 | 22 | 160160 | 15689 | 46510191 |
Attention-seeking behaviour | 12.17 | 9.65 | 6 | 160176 | 83 | 46525797 |
Injection site pruritus | 12.16 | 9.65 | 83 | 160099 | 39660 | 46486220 |
Bladder dilatation | 12.09 | 9.65 | 14 | 160168 | 749 | 46525131 |
Agoraphobia | 12.05 | 9.65 | 10 | 160172 | 354 | 46525526 |
Drug resistance | 12.03 | 9.65 | 26 | 160156 | 17342 | 46508538 |
Pathogen resistance | 11.99 | 9.65 | 3 | 160179 | 6057 | 46519823 |
Brain contusion | 11.98 | 9.65 | 12 | 160170 | 544 | 46525336 |
Obsessive rumination | 11.97 | 9.65 | 3 | 160179 | 3 | 46525877 |
Antidepressant drug level decreased | 11.97 | 9.65 | 3 | 160179 | 3 | 46525877 |
Hypoventilation neonatal | 11.97 | 9.65 | 3 | 160179 | 3 | 46525877 |
International normalised ratio increased | 11.95 | 9.65 | 103 | 160079 | 46780 | 46479100 |
Skin ulcer | 11.92 | 9.65 | 64 | 160118 | 32394 | 46493486 |
Influenza | 11.91 | 9.65 | 225 | 159957 | 89045 | 46436835 |
Dry skin | 11.90 | 9.65 | 87 | 160095 | 40929 | 46484951 |
Blister | 11.85 | 9.65 | 97 | 160085 | 44534 | 46481346 |
Pulmonary oedema | 11.85 | 9.65 | 115 | 160067 | 50990 | 46474890 |
Sleep terror | 11.78 | 9.65 | 14 | 160168 | 770 | 46525110 |
Full blood count decreased | 11.77 | 9.65 | 38 | 160144 | 22173 | 46503707 |
Hypomagnesaemia | 11.77 | 9.65 | 38 | 160144 | 22172 | 46503708 |
Neurotoxicity | 11.77 | 9.65 | 18 | 160164 | 13699 | 46512181 |
Suspected suicide | 11.76 | 9.65 | 39 | 160143 | 4622 | 46521258 |
Myocardial infarction | 11.76 | 9.65 | 250 | 159932 | 97278 | 46428602 |
Purging | 11.75 | 9.65 | 5 | 160177 | 48 | 46525832 |
Formication | 11.73 | 9.65 | 35 | 160147 | 3921 | 46521959 |
Intentional product use issue | 11.72 | 9.65 | 120 | 160062 | 52660 | 46473220 |
Unresponsive to stimuli | 11.72 | 9.65 | 165 | 160017 | 32009 | 46493871 |
Respiratory rate decreased | 11.68 | 9.65 | 30 | 160152 | 3080 | 46522800 |
Narcolepsy | 11.68 | 9.65 | 17 | 160165 | 1142 | 46524738 |
Second primary malignancy | 11.67 | 9.65 | 4 | 160178 | 6580 | 46519300 |
Jaundice | 11.66 | 9.65 | 55 | 160127 | 28790 | 46497090 |
Cerebral vasoconstriction | 11.66 | 9.65 | 16 | 160166 | 1017 | 46524863 |
Exposure via transplant | 11.62 | 9.65 | 4 | 160178 | 20 | 46525860 |
Hepatic enzyme increased | 11.59 | 9.65 | 204 | 159978 | 81583 | 46444297 |
Orgasm abnormal | 11.57 | 9.65 | 6 | 160176 | 93 | 46525787 |
Congenital naevus | 11.51 | 9.65 | 8 | 160174 | 216 | 46525664 |
Gastritis | 11.44 | 9.65 | 70 | 160112 | 34308 | 46491572 |
Focal dyscognitive seizures | 11.38 | 9.65 | 28 | 160154 | 2800 | 46523080 |
Osteoporosis | 11.37 | 9.65 | 87 | 160095 | 40521 | 46485359 |
Arachnoid cyst | 11.35 | 9.65 | 8 | 160174 | 221 | 46525659 |
Rash pruritic | 11.33 | 9.65 | 97 | 160085 | 44118 | 46481762 |
Cerebrovascular accident | 11.33 | 9.65 | 262 | 159920 | 100777 | 46425103 |
Pancreatic failure | 11.31 | 9.65 | 12 | 160170 | 582 | 46525298 |
Somnolence neonatal | 11.24 | 9.65 | 6 | 160176 | 99 | 46525781 |
Tubulointerstitial nephritis | 11.22 | 9.65 | 21 | 160161 | 14767 | 46511113 |
Haemangioma | 11.21 | 9.65 | 26 | 160156 | 2503 | 46523377 |
Xanthopsia | 11.21 | 9.65 | 7 | 160175 | 157 | 46525723 |
Wrong technique in product usage process | 11.17 | 9.65 | 126 | 160056 | 54296 | 46471584 |
Skin disorder | 11.17 | 9.65 | 39 | 160143 | 22224 | 46503656 |
Blood triglycerides increased | 11.17 | 9.65 | 74 | 160108 | 11709 | 46514171 |
Mucocutaneous haemorrhage | 11.16 | 9.65 | 5 | 160177 | 55 | 46525825 |
Premature rupture of membranes | 11.15 | 9.65 | 37 | 160145 | 4386 | 46521494 |
Parkinsonian gait | 11.14 | 9.65 | 11 | 160171 | 490 | 46525390 |
Candida infection | 11.13 | 9.65 | 39 | 160143 | 22201 | 46503679 |
Pupils unequal | 11.13 | 9.65 | 18 | 160164 | 1326 | 46524554 |
Intestinal anastomosis complication | 11.10 | 9.65 | 8 | 160174 | 229 | 46525651 |
Localised infection | 11.09 | 9.65 | 43 | 160139 | 23758 | 46502122 |
Housebound | 11.07 | 9.65 | 8 | 160174 | 230 | 46525650 |
Obsessive-compulsive disorder | 11.05 | 9.65 | 30 | 160152 | 3185 | 46522695 |
Fear | 11.04 | 9.65 | 94 | 160088 | 16078 | 46509802 |
Joint range of motion decreased | 11.02 | 9.65 | 22 | 160160 | 15102 | 46510778 |
Injection site swelling | 11.01 | 9.65 | 87 | 160095 | 40240 | 46485640 |
Bronchopulmonary aspergillosis | 10.99 | 9.65 | 6 | 160176 | 7490 | 46518390 |
Injection site reaction | 10.95 | 9.65 | 108 | 160074 | 47741 | 46478139 |
Increased appetite | 10.95 | 9.65 | 58 | 160124 | 8469 | 46517411 |
Glassy eyes | 10.92 | 9.65 | 5 | 160177 | 58 | 46525822 |
Hyperemesis gravidarum | 10.92 | 9.65 | 11 | 160171 | 502 | 46525378 |
Device difficult to use | 10.90 | 9.65 | 7 | 160175 | 7997 | 46517883 |
Urinary retention | 10.88 | 9.65 | 137 | 160045 | 25924 | 46499956 |
Nephropathy toxic | 10.88 | 9.65 | 6 | 160176 | 7448 | 46518432 |
Neuropsychiatric syndrome | 10.85 | 9.65 | 5 | 160177 | 59 | 46525821 |
Anal fissure | 10.76 | 9.65 | 26 | 160156 | 2570 | 46523310 |
Congenital pharyngeal anomaly | 10.76 | 9.65 | 3 | 160179 | 6 | 46525874 |
Dyskinesia neonatal | 10.76 | 9.65 | 3 | 160179 | 6 | 46525874 |
Cardiomyopathy | 10.75 | 9.65 | 93 | 160089 | 15980 | 46509900 |
Osteomyelitis | 10.71 | 9.65 | 40 | 160142 | 22343 | 46503537 |
Respiratory tract congestion | 10.71 | 9.65 | 17 | 160165 | 12747 | 46513133 |
Atrophic vulvovaginitis | 10.71 | 9.65 | 19 | 160163 | 1509 | 46524371 |
Cytokine release syndrome | 10.65 | 9.65 | 4 | 160178 | 6219 | 46519661 |
Ideas of reference | 10.63 | 9.65 | 5 | 160177 | 62 | 46525818 |
Urosepsis | 10.62 | 9.65 | 23 | 160159 | 15330 | 46510550 |
Platelet aggregation decreased | 10.62 | 9.65 | 4 | 160178 | 27 | 46525853 |
Vision blurred | 10.60 | 9.65 | 353 | 159829 | 79355 | 46446525 |
Haemoptysis | 10.55 | 9.65 | 50 | 160132 | 26139 | 46499741 |
Accidental exposure to product | 10.53 | 9.65 | 37 | 160145 | 21044 | 46504836 |
Impatience | 10.53 | 9.65 | 9 | 160173 | 332 | 46525548 |
Hereditary ataxia | 10.49 | 9.65 | 4 | 160178 | 28 | 46525852 |
Creutzfeldt-Jakob disease | 10.49 | 9.65 | 5 | 160177 | 64 | 46525816 |
Phobia | 10.49 | 9.65 | 9 | 160173 | 334 | 46525546 |
Bronchospasm | 10.48 | 9.65 | 24 | 160158 | 15683 | 46510197 |
Ovarian cancer stage III | 10.44 | 9.65 | 7 | 160175 | 178 | 46525702 |
Haemophagocytic lymphohistiocytosis | 10.43 | 9.65 | 8 | 160174 | 8334 | 46517546 |
Middle insomnia | 10.42 | 9.65 | 62 | 160120 | 9453 | 46516427 |
Ultrasound abdomen abnormal | 10.35 | 9.65 | 5 | 160177 | 66 | 46525814 |
Radius fracture | 10.32 | 9.65 | 30 | 160152 | 3312 | 46522568 |
Dissociative amnesia | 10.26 | 9.65 | 4 | 160178 | 30 | 46525850 |
Lactation disorder | 10.25 | 9.65 | 8 | 160174 | 259 | 46525621 |
Ventricular hypokinesia | 10.18 | 9.65 | 34 | 160148 | 4044 | 46521836 |
Wrong patient received product | 10.17 | 9.65 | 20 | 160162 | 1717 | 46524163 |
Low birth weight baby | 10.16 | 9.65 | 3 | 160179 | 5431 | 46520449 |
Pneumonia viral | 10.16 | 9.65 | 5 | 160177 | 6619 | 46519261 |
Blood prolactin increased | 10.16 | 9.65 | 28 | 160154 | 2999 | 46522881 |
Polycythaemia | 10.15 | 9.65 | 13 | 160169 | 773 | 46525107 |
Congenital foot malformation | 10.14 | 9.65 | 7 | 160175 | 187 | 46525693 |
Hypertonia | 10.07 | 9.65 | 36 | 160146 | 4430 | 46521450 |
Product formulation issue | 10.04 | 9.65 | 12 | 160170 | 664 | 46525216 |
Foetal heart rate deceleration abnormality | 10.04 | 9.65 | 10 | 160172 | 450 | 46525430 |
Ocular hypertension | 10.04 | 9.65 | 13 | 160169 | 781 | 46525099 |
Therapeutic response decreased | 10.04 | 9.65 | 97 | 160085 | 43048 | 46482832 |
Metastases to liver | 10.04 | 9.65 | 34 | 160148 | 19551 | 46506329 |
Device leakage | 9.97 | 9.65 | 3 | 160179 | 5362 | 46520518 |
Staring | 9.95 | 9.65 | 18 | 160164 | 1452 | 46524428 |
Developmental coordination disorder | 9.93 | 9.65 | 4 | 160178 | 33 | 46525847 |
Injection site haemorrhage | 9.91 | 9.65 | 37 | 160145 | 20672 | 46505208 |
Neonatal intestinal obstruction | 9.91 | 9.65 | 3 | 160179 | 9 | 46525871 |
Crush injury | 9.91 | 9.65 | 3 | 160179 | 9 | 46525871 |
Phaeochromocytoma | 9.90 | 9.65 | 10 | 160172 | 458 | 46525422 |
Drug withdrawal convulsions | 9.82 | 9.65 | 17 | 160165 | 1324 | 46524556 |
Hyperchloraemia | 9.80 | 9.65 | 12 | 160170 | 681 | 46525199 |
Polydactyly | 9.79 | 9.65 | 9 | 160173 | 366 | 46525514 |
Hypnagogic hallucination | 9.79 | 9.65 | 6 | 160176 | 130 | 46525750 |
Pleural disorder | 9.77 | 9.65 | 11 | 160171 | 571 | 46525309 |
Haemorrhage | 9.77 | 9.65 | 131 | 160051 | 54738 | 46471142 |
Amphetamines positive | 9.73 | 9.65 | 5 | 160177 | 76 | 46525804 |
Obstructive airways disorder | 9.72 | 9.65 | 79 | 160103 | 13333 | 46512547 |
Communication disorder | 9.69 | 9.65 | 24 | 160158 | 2409 | 46523471 |
Non-small cell lung cancer recurrent | 9.67 | 9.65 | 3 | 160179 | 10 | 46525870 |
Urinary tract discomfort | 9.67 | 9.65 | 5 | 160177 | 77 | 46525803 |
Pseudophaeochromocytoma | 9.67 | 9.65 | 5 | 160177 | 77 | 46525803 |
Dehydration | 9.66 | 9.65 | 448 | 159734 | 159092 | 46366788 |
Exposure via ingestion | 9.65 | 9.65 | 30 | 160152 | 3437 | 46522443 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 799.42 | 10.56 | 1058 | 67537 | 98434 | 29785449 |
Serotonin syndrome | 644.26 | 10.56 | 439 | 68156 | 17452 | 29866431 |
Drug withdrawal syndrome | 454.78 | 10.56 | 371 | 68224 | 19438 | 29864445 |
Suicide attempt | 431.13 | 10.56 | 474 | 68121 | 36223 | 29847660 |
Suicidal ideation | 407.92 | 10.56 | 457 | 68138 | 35657 | 29848226 |
Intentional overdose | 396.91 | 10.56 | 482 | 68113 | 40999 | 29842884 |
Toxicity to various agents | 385.37 | 10.56 | 1079 | 67516 | 176104 | 29707779 |
Depression | 277.04 | 10.56 | 628 | 67967 | 89809 | 29794074 |
Overdose | 264.27 | 10.56 | 591 | 68004 | 83746 | 29800137 |
Withdrawal syndrome | 201.72 | 10.56 | 183 | 68412 | 11067 | 29872816 |
Anxiety | 191.40 | 10.56 | 544 | 68051 | 89327 | 29794556 |
Agitation | 161.47 | 10.56 | 372 | 68223 | 53701 | 29830182 |
Maternal exposure during pregnancy | 161.01 | 10.56 | 104 | 68491 | 3767 | 29880116 |
Mania | 152.64 | 10.56 | 143 | 68452 | 9011 | 29874872 |
Hyperhidrosis | 140.68 | 10.56 | 404 | 68191 | 66686 | 29817197 |
Coma | 138.48 | 10.56 | 294 | 68301 | 40155 | 29843728 |
Disturbance in attention | 137.98 | 10.56 | 209 | 68386 | 21920 | 29861963 |
Pneumonia | 137.47 | 10.56 | 357 | 68238 | 333949 | 29549934 |
Drug interaction | 134.95 | 10.56 | 849 | 67746 | 198719 | 29685164 |
Febrile neutropenia | 132.26 | 10.56 | 40 | 68555 | 106653 | 29777230 |
Poisoning deliberate | 132.08 | 10.56 | 109 | 68486 | 5795 | 29878088 |
Mydriasis | 128.30 | 10.56 | 109 | 68486 | 6034 | 29877849 |
Exposure during pregnancy | 125.19 | 10.56 | 129 | 68466 | 9132 | 29874751 |
Selective eating disorder | 122.48 | 10.56 | 65 | 68530 | 1619 | 29882264 |
Drug withdrawal syndrome neonatal | 119.16 | 10.56 | 80 | 68515 | 3095 | 29880788 |
Respiratory disorder neonatal | 119.15 | 10.56 | 57 | 68538 | 1131 | 29882752 |
Foetal exposure during pregnancy | 118.20 | 10.56 | 261 | 68334 | 36610 | 29847273 |
Drug abuse | 117.59 | 10.56 | 434 | 68161 | 81638 | 29802245 |
Anaemia | 116.04 | 10.56 | 186 | 68409 | 207806 | 29676077 |
Intentional self-injury | 112.93 | 10.56 | 147 | 68448 | 13385 | 29870498 |
Hypotonia neonatal | 111.27 | 10.56 | 52 | 68543 | 977 | 29882906 |
Pyrexia | 110.14 | 10.56 | 329 | 68266 | 294160 | 29589723 |
Somnolence | 109.23 | 10.56 | 475 | 68120 | 96288 | 29787595 |
Tremor | 107.50 | 10.56 | 398 | 68197 | 74965 | 29808918 |
Major depression | 106.53 | 10.56 | 82 | 68513 | 3940 | 29879943 |
Neonatal respiratory distress syndrome | 100.20 | 10.56 | 79 | 68516 | 3933 | 29879950 |
Restlessness | 93.75 | 10.56 | 178 | 68417 | 22421 | 29861462 |
Hyperreflexia | 93.49 | 10.56 | 66 | 68529 | 2773 | 29881110 |
Cataplexy | 92.12 | 10.56 | 34 | 68561 | 339 | 29883544 |
Sepsis | 91.29 | 10.56 | 121 | 68474 | 146274 | 29737609 |
Irritability | 88.84 | 10.56 | 176 | 68419 | 22874 | 29861009 |
Sopor | 88.00 | 10.56 | 117 | 68478 | 10874 | 29873009 |
Drug dependence | 87.43 | 10.56 | 167 | 68428 | 21128 | 29862755 |
Rash | 82.43 | 10.56 | 200 | 68395 | 191689 | 29692194 |
Dyspnoea | 81.12 | 10.56 | 441 | 68154 | 332854 | 29551029 |
Aggression | 80.95 | 10.56 | 226 | 68369 | 36681 | 29847202 |
Myoclonus | 79.12 | 10.56 | 123 | 68472 | 13189 | 29870694 |
Bipolar disorder | 74.78 | 10.56 | 65 | 68530 | 3711 | 29880172 |
Acute kidney injury | 74.75 | 10.56 | 348 | 68247 | 273494 | 29610389 |
Seizure | 74.64 | 10.56 | 432 | 68163 | 98043 | 29785840 |
Diarrhoea | 73.83 | 10.56 | 456 | 68139 | 333647 | 29550236 |
Poisoning | 73.06 | 10.56 | 109 | 68486 | 11273 | 29872610 |
Talipes | 72.12 | 10.56 | 46 | 68549 | 1629 | 29882254 |
Bradycardia neonatal | 68.44 | 10.56 | 36 | 68559 | 880 | 29883003 |
Agitation neonatal | 67.39 | 10.56 | 37 | 68558 | 988 | 29882895 |
Infantile apnoea | 66.60 | 10.56 | 35 | 68560 | 854 | 29883029 |
Neutropenia | 66.02 | 10.56 | 121 | 68474 | 128419 | 29755464 |
Psychotic disorder | 65.23 | 10.56 | 149 | 68446 | 21366 | 29862517 |
Anger | 65.05 | 10.56 | 102 | 68493 | 11018 | 29872865 |
Death | 64.08 | 10.56 | 518 | 68077 | 356765 | 29527118 |
Erectile dysfunction | 63.56 | 10.56 | 133 | 68462 | 17969 | 29865914 |
Small for dates baby | 63.08 | 10.56 | 55 | 68540 | 3153 | 29880730 |
Postmortem blood drug level increased | 62.99 | 10.56 | 20 | 68575 | 120 | 29883763 |
Atrial septal defect | 62.57 | 10.56 | 77 | 68518 | 6624 | 29877259 |
Depressed mood | 62.00 | 10.56 | 127 | 68468 | 16902 | 29866981 |
Interstitial lung disease | 60.68 | 10.56 | 31 | 68564 | 60166 | 29823717 |
Sedation | 59.48 | 10.56 | 122 | 68473 | 16251 | 29867632 |
Hallucination, auditory | 58.94 | 10.56 | 91 | 68504 | 9698 | 29874185 |
Nightmare | 58.82 | 10.56 | 102 | 68493 | 11974 | 29871909 |
Electrocardiogram QT prolonged | 58.55 | 10.56 | 198 | 68397 | 35637 | 29848246 |
Maternal drugs affecting foetus | 56.80 | 10.56 | 59 | 68536 | 4214 | 29879669 |
Delusion | 56.75 | 10.56 | 100 | 68495 | 11889 | 29871994 |
Insomnia | 56.70 | 10.56 | 387 | 68208 | 92949 | 29790934 |
Homicide | 55.96 | 10.56 | 33 | 68562 | 1013 | 29882870 |
Hallucination, visual | 54.96 | 10.56 | 117 | 68478 | 15996 | 29867887 |
Psychotic symptom | 54.57 | 10.56 | 34 | 68561 | 1155 | 29882728 |
Cardiac failure congestive | 54.37 | 10.56 | 68 | 68527 | 84339 | 29799544 |
Dyskinesia | 54.20 | 10.56 | 140 | 68455 | 21694 | 29862189 |
Off label use | 54.05 | 10.56 | 342 | 68253 | 248948 | 29634935 |
Malignant neoplasm progression | 53.42 | 10.56 | 52 | 68543 | 72235 | 29811648 |
Disease progression | 51.81 | 10.56 | 64 | 68531 | 79810 | 29804073 |
Platelet count decreased | 51.76 | 10.56 | 103 | 68492 | 106026 | 29777857 |
Antipsychotic drug level above therapeutic | 50.13 | 10.56 | 31 | 68564 | 1039 | 29882844 |
Rheumatoid arthritis | 50.00 | 10.56 | 16 | 68579 | 41181 | 29842702 |
Renal impairment | 49.98 | 10.56 | 72 | 68523 | 84112 | 29799771 |
Somnambulism | 49.38 | 10.56 | 48 | 68547 | 3166 | 29880717 |
Tachycardia | 49.17 | 10.56 | 313 | 68282 | 73426 | 29810457 |
Haemoglobin decreased | 48.06 | 10.56 | 120 | 68475 | 113978 | 29769905 |
Hypertonia neonatal | 47.59 | 10.56 | 21 | 68574 | 343 | 29883540 |
Impulsive behaviour | 47.58 | 10.56 | 38 | 68557 | 1927 | 29881956 |
Cough | 47.04 | 10.56 | 140 | 68455 | 125502 | 29758381 |
Hypertonia | 46.89 | 10.56 | 54 | 68541 | 4331 | 29879552 |
Sexual dysfunction | 46.69 | 10.56 | 63 | 68532 | 5938 | 29877945 |
Antidepressant drug level increased | 46.55 | 10.56 | 15 | 68580 | 95 | 29883788 |
Neuroleptic malignant syndrome | 46.27 | 10.56 | 110 | 68485 | 16185 | 29867698 |
Plasma cell myeloma | 46.23 | 10.56 | 33 | 68562 | 53429 | 29830454 |
Pruritus | 45.49 | 10.56 | 130 | 68465 | 118074 | 29765809 |
Neonatal tachypnoea | 44.67 | 10.56 | 15 | 68580 | 110 | 29883773 |
Altered state of consciousness | 43.68 | 10.56 | 122 | 68473 | 19797 | 29864086 |
Neuropathy peripheral | 43.10 | 10.56 | 59 | 68536 | 70416 | 29813467 |
Confusional state | 42.99 | 10.56 | 485 | 68110 | 134349 | 29749534 |
Parkinsonism | 42.96 | 10.56 | 67 | 68528 | 7202 | 29876681 |
Akathisia | 42.94 | 10.56 | 60 | 68535 | 5844 | 29878039 |
Cytomegalovirus infection | 42.55 | 10.56 | 3 | 68592 | 23671 | 29860212 |
Erythema | 42.37 | 10.56 | 70 | 68525 | 77381 | 29806502 |
Feeling jittery | 42.19 | 10.56 | 48 | 68547 | 3800 | 29880083 |
Panic attack | 41.85 | 10.56 | 73 | 68522 | 8608 | 29875275 |
Drug screen positive | 41.73 | 10.56 | 51 | 68544 | 4356 | 29879527 |
Thrombocytopenia | 41.64 | 10.56 | 167 | 68428 | 136877 | 29747006 |
Infection | 41.39 | 10.56 | 72 | 68523 | 78002 | 29805881 |
Electrocardiogram QRS complex prolonged | 41.32 | 10.56 | 50 | 68545 | 4227 | 29879656 |
Septic shock | 41.21 | 10.56 | 51 | 68544 | 63556 | 29820327 |
Hypomania | 41.02 | 10.56 | 37 | 68558 | 2219 | 29881664 |
Self-injurious ideation | 40.86 | 10.56 | 32 | 68563 | 1577 | 29882306 |
Respiratory failure | 40.72 | 10.56 | 108 | 68487 | 100534 | 29783349 |
Multiple organ dysfunction syndrome | 39.99 | 10.56 | 52 | 68543 | 63435 | 29820448 |
Memory impairment | 39.97 | 10.56 | 180 | 68415 | 36994 | 29846889 |
Stress cardiomyopathy | 39.75 | 10.56 | 31 | 68564 | 1518 | 29882365 |
Social anxiety disorder | 39.66 | 10.56 | 17 | 68578 | 258 | 29883625 |
Miosis | 39.60 | 10.56 | 67 | 68528 | 7709 | 29876174 |
Product substitution issue | 39.11 | 10.56 | 77 | 68518 | 9958 | 29873925 |
Intentional product misuse | 38.89 | 10.56 | 170 | 68425 | 34497 | 29849386 |
Pancytopenia | 38.56 | 10.56 | 86 | 68509 | 84966 | 29798917 |
Bone marrow failure | 37.16 | 10.56 | 11 | 68584 | 29774 | 29854109 |
Paranoia | 35.93 | 10.56 | 75 | 68520 | 10113 | 29873770 |
Gastrointestinal haemorrhage | 35.72 | 10.56 | 87 | 68508 | 83359 | 29800524 |
Feeling abnormal | 35.43 | 10.56 | 237 | 68358 | 56519 | 29827364 |
Atrial fibrillation | 35.26 | 10.56 | 128 | 68467 | 107996 | 29775887 |
Hepatic function abnormal | 34.83 | 10.56 | 27 | 68568 | 41918 | 29841965 |
Homicidal ideation | 34.53 | 10.56 | 35 | 68560 | 2428 | 29881455 |
Clonus | 34.32 | 10.56 | 35 | 68560 | 2446 | 29881437 |
Blood creatinine increased | 34.05 | 10.56 | 102 | 68493 | 91273 | 29792610 |
Feelings of worthlessness | 34.00 | 10.56 | 14 | 68581 | 191 | 29883692 |
Logorrhoea | 33.70 | 10.56 | 32 | 68563 | 2050 | 29881833 |
Pleural effusion | 33.48 | 10.56 | 75 | 68520 | 73991 | 29809892 |
Premature baby | 33.46 | 10.56 | 99 | 68496 | 16592 | 29867291 |
Mucosal inflammation | 33.36 | 10.56 | 14 | 68581 | 30480 | 29853403 |
Neonatal toxicity | 33.32 | 10.56 | 9 | 68586 | 27 | 29883856 |
Muscle rigidity | 33.26 | 10.56 | 73 | 68522 | 10188 | 29873695 |
Abnormal behaviour | 32.92 | 10.56 | 131 | 68464 | 25492 | 29858391 |
Thinking abnormal | 32.86 | 10.56 | 50 | 68545 | 5261 | 29878622 |
Macrophages increased | 32.71 | 10.56 | 13 | 68582 | 161 | 29883722 |
Tearfulness | 32.67 | 10.56 | 28 | 68567 | 1568 | 29882315 |
Libido decreased | 32.61 | 10.56 | 46 | 68549 | 4520 | 29879363 |
Apgar score low | 32.49 | 10.56 | 22 | 68573 | 863 | 29883020 |
Multiple drug therapy | 31.49 | 10.56 | 14 | 68581 | 233 | 29883650 |
Arthralgia | 31.07 | 10.56 | 183 | 68412 | 135608 | 29748275 |
Stomatitis | 30.95 | 10.56 | 24 | 68571 | 37255 | 29846628 |
Mood altered | 30.58 | 10.56 | 62 | 68533 | 8188 | 29875695 |
Tardive dyskinesia | 30.43 | 10.56 | 47 | 68548 | 5010 | 29878873 |
Normal pressure hydrocephalus | 30.31 | 10.56 | 12 | 68583 | 147 | 29883736 |
Abnormal dreams | 30.10 | 10.56 | 61 | 68534 | 8054 | 29875829 |
Ejaculation disorder | 30.07 | 10.56 | 22 | 68573 | 978 | 29882905 |
Disorientation | 30.02 | 10.56 | 147 | 68448 | 31271 | 29852612 |
Poor quality sleep | 29.97 | 10.56 | 57 | 68538 | 7184 | 29876699 |
Cognitive disorder | 29.54 | 10.56 | 120 | 68475 | 23570 | 29860313 |
Psychomotor hyperactivity | 29.54 | 10.56 | 61 | 68534 | 8163 | 29875720 |
Sleep apnoea syndrome | 29.18 | 10.56 | 95 | 68500 | 16762 | 29867121 |
Dysphoria | 29.17 | 10.56 | 30 | 68565 | 2118 | 29881765 |
Myocardial fibrosis | 29.07 | 10.56 | 19 | 68576 | 702 | 29883181 |
Weight increased | 28.81 | 10.56 | 280 | 68315 | 74633 | 29809250 |
Fall | 28.75 | 10.56 | 580 | 68015 | 181292 | 29702591 |
Urinary retention | 28.63 | 10.56 | 150 | 68445 | 32767 | 29851116 |
Chronic kidney disease | 28.20 | 10.56 | 27 | 68568 | 37811 | 29846072 |
Disseminated intravascular coagulation | 28.00 | 10.56 | 8 | 68587 | 22163 | 29861720 |
Encephalopathy neonatal | 27.85 | 10.56 | 8 | 68587 | 32 | 29883851 |
Muscle twitching | 27.56 | 10.56 | 59 | 68536 | 8096 | 29875787 |
Depression suicidal | 27.38 | 10.56 | 23 | 68572 | 1253 | 29882630 |
Respiratory arrest | 27.31 | 10.56 | 136 | 68459 | 29122 | 29854761 |
Electric shock | 27.20 | 10.56 | 11 | 68584 | 143 | 29883740 |
Neonatal disorder | 27.00 | 10.56 | 20 | 68575 | 906 | 29882977 |
Stevens-Johnson syndrome | 26.98 | 10.56 | 4 | 68591 | 17552 | 29866331 |
Extrapyramidal disorder | 26.98 | 10.56 | 69 | 68526 | 10624 | 29873259 |
Alcoholism | 26.80 | 10.56 | 36 | 68559 | 3378 | 29880505 |
Mental impairment | 26.74 | 10.56 | 63 | 68532 | 9214 | 29874669 |
Oedema peripheral | 26.73 | 10.56 | 138 | 68457 | 105694 | 29778189 |
Acoustic stimulation tests abnormal | 26.46 | 10.56 | 9 | 68586 | 69 | 29883814 |
Pressure of speech | 26.45 | 10.56 | 15 | 68580 | 427 | 29883456 |
Hyperthermia | 26.35 | 10.56 | 66 | 68529 | 10033 | 29873850 |
Implant site extravasation | 26.23 | 10.56 | 15 | 68580 | 434 | 29883449 |
Blood ethanol increased | 26.15 | 10.56 | 14 | 68581 | 355 | 29883528 |
Pneumocystis jirovecii pneumonia | 26.09 | 10.56 | 4 | 68591 | 17116 | 29866767 |
Sleep disorder | 25.91 | 10.56 | 118 | 68477 | 24361 | 29859522 |
Head circumference abnormal | 25.78 | 10.56 | 8 | 68587 | 44 | 29883839 |
Obsessive-compulsive disorder | 25.64 | 10.56 | 39 | 68556 | 4102 | 29879781 |
Cardio-respiratory arrest | 25.47 | 10.56 | 221 | 68374 | 57085 | 29826798 |
Neonatal testicular torsion | 25.41 | 10.56 | 5 | 68590 | 0 | 29883883 |
Product residue present | 25.37 | 10.56 | 31 | 68564 | 2647 | 29881236 |
Otospondylomegaepiphyseal dysplasia | 25.29 | 10.56 | 10 | 68585 | 122 | 29883761 |
Dry mouth | 24.82 | 10.56 | 111 | 68484 | 22739 | 29861144 |
Neonatal respiratory failure | 24.78 | 10.56 | 13 | 68582 | 316 | 29883567 |
Peritonitis | 24.72 | 10.56 | 9 | 68586 | 21366 | 29862517 |
Restless legs syndrome | 24.71 | 10.56 | 51 | 68544 | 6821 | 29877062 |
Thermophobia | 24.54 | 10.56 | 9 | 68586 | 88 | 29883795 |
Foetal malnutrition | 24.52 | 10.56 | 8 | 68587 | 53 | 29883830 |
Acute myocardial infarction | 24.42 | 10.56 | 53 | 68542 | 52886 | 29830997 |
International normalised ratio increased | 24.41 | 10.56 | 45 | 68550 | 47694 | 29836189 |
External auditory canal atresia | 24.38 | 10.56 | 10 | 68585 | 135 | 29883748 |
Drug hypersensitivity | 24.36 | 10.56 | 252 | 68343 | 68267 | 29815616 |
Patent ductus arteriosus | 24.24 | 10.56 | 33 | 68562 | 3136 | 29880747 |
Pyramidal tract syndrome | 24.11 | 10.56 | 11 | 68584 | 195 | 29883688 |
Wrong dose | 23.88 | 10.56 | 13 | 68582 | 341 | 29883542 |
Hypospadias | 23.75 | 10.56 | 30 | 68565 | 2649 | 29881234 |
Pneumonitis | 23.65 | 10.56 | 17 | 68578 | 27437 | 29856446 |
Eosinophilic myocarditis | 23.64 | 10.56 | 14 | 68581 | 433 | 29883450 |
Blood cholesterol increased | 23.63 | 10.56 | 89 | 68506 | 16881 | 29867002 |
Arachnoid cyst | 23.33 | 10.56 | 11 | 68584 | 211 | 29883672 |
Bipolar II disorder | 23.30 | 10.56 | 6 | 68589 | 14 | 29883869 |
Apathy | 23.30 | 10.56 | 47 | 68548 | 6185 | 29877698 |
Euphoric mood | 23.23 | 10.56 | 38 | 68557 | 4252 | 29879631 |
Cerebral infarction | 23.16 | 10.56 | 16 | 68579 | 26357 | 29857526 |
Neonatal respiratory distress | 23.05 | 10.56 | 14 | 68581 | 454 | 29883429 |
Decreased appetite | 22.92 | 10.56 | 226 | 68369 | 149684 | 29734199 |
Congenital megaureter | 22.90 | 10.56 | 9 | 68586 | 108 | 29883775 |
Renal aplasia | 22.88 | 10.56 | 16 | 68579 | 662 | 29883221 |
Infusion related reaction | 22.79 | 10.56 | 36 | 68559 | 40528 | 29843355 |
Tremor neonatal | 22.77 | 10.56 | 13 | 68582 | 375 | 29883508 |
Cardiac failure | 22.65 | 10.56 | 106 | 68489 | 83312 | 29800571 |
Renal failure | 22.51 | 10.56 | 188 | 68407 | 128778 | 29755105 |
Joint swelling | 22.49 | 10.56 | 46 | 68549 | 46900 | 29836983 |
Salivary hypersecretion | 22.48 | 10.56 | 52 | 68543 | 7514 | 29876369 |
Depressive symptom | 22.38 | 10.56 | 23 | 68572 | 1622 | 29882261 |
Paraesthesia | 22.34 | 10.56 | 206 | 68389 | 54121 | 29829762 |
Metabolic syndrome | 22.02 | 10.56 | 22 | 68573 | 1500 | 29882383 |
Anaphylactic reaction | 22.00 | 10.56 | 19 | 68576 | 27963 | 29855920 |
Iris coloboma | 21.97 | 10.56 | 6 | 68589 | 19 | 29883864 |
Norepinephrine increased | 21.95 | 10.56 | 5 | 68590 | 5 | 29883878 |
Retinal coloboma | 21.74 | 10.56 | 6 | 68589 | 20 | 29883863 |
Priapism | 21.72 | 10.56 | 39 | 68556 | 4704 | 29879179 |
Muscle mass | 21.48 | 10.56 | 11 | 68584 | 254 | 29883629 |
Testicular atrophy | 21.45 | 10.56 | 14 | 68581 | 516 | 29883367 |
Condition aggravated | 21.21 | 10.56 | 438 | 68157 | 137428 | 29746455 |
Histamine level increased | 21.13 | 10.56 | 7 | 68588 | 49 | 29883834 |
Mood swings | 21.13 | 10.56 | 51 | 68544 | 7575 | 29876308 |
Personality disorder | 21.11 | 10.56 | 19 | 68576 | 1136 | 29882747 |
Kidney duplex | 21.09 | 10.56 | 12 | 68583 | 344 | 29883539 |
Toxic cardiomyopathy | 21.06 | 10.56 | 10 | 68585 | 195 | 29883688 |
Poor sucking reflex | 20.98 | 10.56 | 11 | 68584 | 267 | 29883616 |
Emotional disorder | 20.96 | 10.56 | 40 | 68555 | 5054 | 29878829 |
Persistent depressive disorder | 20.91 | 10.56 | 11 | 68584 | 269 | 29883614 |
Coagulation disorder neonatal | 20.89 | 10.56 | 6 | 68589 | 24 | 29883859 |
White blood cell count decreased | 20.88 | 10.56 | 110 | 68485 | 83837 | 29800046 |
Penoscrotal fusion | 20.65 | 10.56 | 5 | 68590 | 8 | 29883875 |
Gun shot wound | 20.51 | 10.56 | 19 | 68576 | 1179 | 29882704 |
Pulmonary contusion | 20.43 | 10.56 | 7 | 68588 | 55 | 29883828 |
Loose associations | 20.43 | 10.56 | 7 | 68588 | 55 | 29883828 |
Onychomycosis | 20.43 | 10.56 | 25 | 68570 | 2138 | 29881745 |
Cerebrovascular accident | 20.42 | 10.56 | 110 | 68485 | 83367 | 29800516 |
Haematoma | 20.42 | 10.56 | 15 | 68580 | 23938 | 29859945 |
Hypervigilance | 20.34 | 10.56 | 9 | 68586 | 148 | 29883735 |
Inappropriate antidiuretic hormone secretion | 20.33 | 10.56 | 65 | 68530 | 11357 | 29872526 |
Dyskinesia neonatal | 20.33 | 10.56 | 4 | 68591 | 0 | 29883883 |
Bruxism | 20.32 | 10.56 | 20 | 68575 | 1339 | 29882544 |
External ear disorder | 20.32 | 10.56 | 6 | 68589 | 27 | 29883856 |
Hyperkalaemia | 20.30 | 10.56 | 80 | 68515 | 65930 | 29817953 |
Loss of consciousness | 20.27 | 10.56 | 274 | 68321 | 79101 | 29804782 |
Decreased interest | 20.13 | 10.56 | 25 | 68570 | 2170 | 29881713 |
Foaming at mouth | 20.09 | 10.56 | 15 | 68580 | 688 | 29883195 |
Myelodysplastic syndrome | 19.94 | 10.56 | 9 | 68586 | 18769 | 29865114 |
Electrocardiogram QT shortened | 19.86 | 10.56 | 9 | 68586 | 157 | 29883726 |
Epilepsy | 19.71 | 10.56 | 95 | 68500 | 20074 | 29863809 |
Congenital central nervous system anomaly | 19.57 | 10.56 | 12 | 68583 | 396 | 29883487 |
Temperature regulation disorder | 19.45 | 10.56 | 13 | 68582 | 499 | 29883384 |
Heat stroke | 19.33 | 10.56 | 16 | 68579 | 854 | 29883029 |
Alopecia | 19.30 | 10.56 | 10 | 68585 | 19265 | 29864618 |
Amnesia | 19.23 | 10.56 | 108 | 68487 | 24213 | 29859670 |
Enuresis | 19.23 | 10.56 | 22 | 68573 | 1752 | 29882131 |
Ascites | 19.14 | 10.56 | 33 | 68562 | 35888 | 29847995 |
Liver disorder | 19.06 | 10.56 | 24 | 68571 | 29698 | 29854185 |
Persecutory delusion | 19.03 | 10.56 | 24 | 68571 | 2116 | 29881767 |
Rhabdomyolysis | 19.01 | 10.56 | 226 | 68369 | 63354 | 29820529 |
Affective disorder | 18.86 | 10.56 | 29 | 68566 | 3079 | 29880804 |
Delirium | 18.74 | 10.56 | 158 | 68437 | 40473 | 29843410 |
Splenomegaly | 18.70 | 10.56 | 4 | 68591 | 13476 | 29870407 |
Violence-related symptom | 18.67 | 10.56 | 13 | 68582 | 534 | 29883349 |
Colitis | 18.63 | 10.56 | 26 | 68569 | 30794 | 29853089 |
Gastrointestinal hypermotility | 18.63 | 10.56 | 8 | 68587 | 122 | 29883761 |
Accommodation disorder | 18.48 | 10.56 | 9 | 68586 | 186 | 29883697 |
Suicidal behaviour | 18.45 | 10.56 | 19 | 68576 | 1343 | 29882540 |
Dizziness | 18.39 | 10.56 | 580 | 68015 | 194329 | 29689554 |
Cerebral ventricle dilatation | 18.34 | 10.56 | 15 | 68580 | 787 | 29883096 |
Blood bilirubin increased | 18.32 | 10.56 | 35 | 68560 | 36601 | 29847282 |
Loss of libido | 18.32 | 10.56 | 23 | 68572 | 2019 | 29881864 |
Crying | 18.29 | 10.56 | 40 | 68555 | 5569 | 29878314 |
Drug reaction with eosinophilia and systemic symptoms | 18.27 | 10.56 | 23 | 68572 | 28465 | 29855418 |
Hangover | 18.27 | 10.56 | 17 | 68578 | 1061 | 29882822 |
Maternal exposure timing unspecified | 18.21 | 10.56 | 11 | 68584 | 353 | 29883530 |
Urticaria | 18.21 | 10.56 | 64 | 68531 | 54542 | 29829341 |
Diarrhoea neonatal | 18.04 | 10.56 | 5 | 68590 | 17 | 29883866 |
Bradykinesia | 18.02 | 10.56 | 29 | 68566 | 3201 | 29880682 |
Rebound effect | 18.01 | 10.56 | 20 | 68575 | 1541 | 29882342 |
Blunted affect | 17.85 | 10.56 | 10 | 68585 | 278 | 29883605 |
Social avoidant behaviour | 17.77 | 10.56 | 27 | 68568 | 2836 | 29881047 |
Visual evoked potentials abnormal | 17.73 | 10.56 | 7 | 68588 | 85 | 29883798 |
Floppy infant | 17.66 | 10.56 | 7 | 68588 | 86 | 29883797 |
Generalised tonic-clonic seizure | 17.63 | 10.56 | 90 | 68505 | 19461 | 29864422 |
Sleep paralysis | 17.58 | 10.56 | 8 | 68587 | 141 | 29883742 |
Peripheral swelling | 17.54 | 10.56 | 76 | 68519 | 60998 | 29822885 |
Catatonia | 17.54 | 10.56 | 34 | 68561 | 4346 | 29879537 |
Oedema | 17.47 | 10.56 | 46 | 68549 | 42947 | 29840936 |
Bradyphrenia | 17.44 | 10.56 | 32 | 68563 | 3925 | 29879958 |
Hypoxia | 17.39 | 10.56 | 54 | 68541 | 47800 | 29836083 |
Prescribed overdose | 17.37 | 10.56 | 51 | 68544 | 8510 | 29875373 |
Male orgasmic disorder | 17.31 | 10.56 | 7 | 68588 | 91 | 29883792 |
Drug screen false positive | 17.27 | 10.56 | 14 | 68581 | 725 | 29883158 |
Food aversion | 17.25 | 10.56 | 10 | 68585 | 297 | 29883586 |
Influenza | 17.21 | 10.56 | 47 | 68548 | 43351 | 29840532 |
Selective mutism | 17.10 | 10.56 | 6 | 68589 | 51 | 29883832 |
Physical examination abnormal | 17.04 | 10.56 | 7 | 68588 | 95 | 29883788 |
Infantile vomiting | 17.03 | 10.56 | 5 | 68590 | 22 | 29883861 |
Affect lability | 16.81 | 10.56 | 29 | 68566 | 3389 | 29880494 |
Phaeochromocytoma malignant | 16.80 | 10.56 | 6 | 68589 | 54 | 29883829 |
Haematuria | 16.72 | 10.56 | 50 | 68545 | 44784 | 29839099 |
Dysgraphia | 16.62 | 10.56 | 19 | 68576 | 1512 | 29882371 |
Physical assault | 16.58 | 10.56 | 17 | 68578 | 1196 | 29882687 |
Diastolic hypotension | 16.51 | 10.56 | 5 | 68590 | 25 | 29883858 |
Blood creatine phosphokinase increased | 16.41 | 10.56 | 163 | 68432 | 43685 | 29840198 |
Lymphadenopathy | 16.36 | 10.56 | 19 | 68576 | 24357 | 29859526 |
Bronchopulmonary aspergillosis | 16.33 | 10.56 | 4 | 68591 | 12280 | 29871603 |
Action tremor | 16.33 | 10.56 | 6 | 68589 | 59 | 29883824 |
Potentiating drug interaction | 16.22 | 10.56 | 34 | 68561 | 4597 | 29879286 |
Micturition urgency | 16.19 | 10.56 | 33 | 68562 | 4374 | 29879509 |
Hospitalisation | 16.12 | 10.56 | 50 | 68545 | 44269 | 29839614 |
Derealisation | 16.06 | 10.56 | 12 | 68583 | 551 | 29883332 |
Palmar-plantar erythrodysaesthesia syndrome | 15.99 | 10.56 | 7 | 68588 | 14863 | 29869020 |
Thrombosis | 15.82 | 10.56 | 47 | 68548 | 42184 | 29841699 |
Product dose omission issue | 15.79 | 10.56 | 134 | 68461 | 91497 | 29792386 |
Contraindicated product administered | 15.74 | 10.56 | 10 | 68585 | 17221 | 29866662 |
Chills | 15.73 | 10.56 | 99 | 68496 | 72239 | 29811644 |
Acute myeloid leukaemia | 15.71 | 10.56 | 11 | 68584 | 17995 | 29865888 |
Dissociation | 15.66 | 10.56 | 16 | 68579 | 1121 | 29882762 |
Coagulation factor VII level decreased | 15.61 | 10.56 | 7 | 68588 | 119 | 29883764 |
Psychomotor retardation | 15.58 | 10.56 | 23 | 68572 | 2356 | 29881527 |
Anal stenosis | 15.56 | 10.56 | 7 | 68588 | 120 | 29883763 |
Cyanosis neonatal | 15.51 | 10.56 | 9 | 68586 | 268 | 29883615 |
Stress | 15.44 | 10.56 | 89 | 68506 | 20146 | 29863737 |
Obsessive-compulsive symptom | 15.42 | 10.56 | 6 | 68589 | 70 | 29883813 |
Cerebral disorder | 15.35 | 10.56 | 23 | 68572 | 2387 | 29881496 |
Cerebral microangiopathy | 15.34 | 10.56 | 8 | 68587 | 192 | 29883691 |
Forearm fracture | 15.34 | 10.56 | 6 | 68589 | 71 | 29883812 |
Withdrawal catatonia | 15.26 | 10.56 | 6 | 68589 | 72 | 29883811 |
Kleptomania | 15.24 | 10.56 | 3 | 68592 | 0 | 29883883 |
Tinnitus | 15.17 | 10.56 | 75 | 68520 | 16013 | 29867870 |
Anorgasmia | 15.12 | 10.56 | 12 | 68583 | 603 | 29883280 |
Wheezing | 15.08 | 10.56 | 30 | 68565 | 30908 | 29852975 |
Hepatic failure | 14.95 | 10.56 | 35 | 68560 | 34008 | 29849875 |
CADASIL | 14.90 | 10.56 | 6 | 68589 | 77 | 29883806 |
Ultrasound skull abnormal | 14.90 | 10.56 | 6 | 68589 | 77 | 29883806 |
Opisthotonus | 14.87 | 10.56 | 10 | 68585 | 388 | 29883495 |
Meningocele | 14.85 | 10.56 | 5 | 68590 | 37 | 29883846 |
Head discomfort | 14.85 | 10.56 | 25 | 68570 | 2865 | 29881018 |
Dysarthria | 14.82 | 10.56 | 120 | 68475 | 30370 | 29853513 |
Rash maculo-papular | 14.81 | 10.56 | 22 | 68573 | 25396 | 29858487 |
Blood urea increased | 14.81 | 10.56 | 31 | 68564 | 31350 | 29852533 |
Urinary straining | 14.81 | 10.56 | 4 | 68591 | 12 | 29883871 |
Physical deconditioning | 14.76 | 10.56 | 12 | 68583 | 624 | 29883259 |
Unemployment | 14.74 | 10.56 | 5 | 68590 | 38 | 29883845 |
Hypomagnesaemia | 14.66 | 10.56 | 10 | 68585 | 16588 | 29867295 |
Magnetic resonance imaging spinal abnormal | 14.63 | 10.56 | 6 | 68589 | 81 | 29883802 |
Reduced facial expression | 14.59 | 10.56 | 13 | 68582 | 767 | 29883116 |
Abnormal palmar/plantar creases | 14.56 | 10.56 | 8 | 68587 | 214 | 29883669 |
Muscle necrosis | 14.53 | 10.56 | 13 | 68582 | 771 | 29883112 |
Tricuspid valve sclerosis | 14.51 | 10.56 | 5 | 68590 | 40 | 29883843 |
Fatigue | 14.51 | 10.56 | 594 | 68001 | 320079 | 29563804 |
Antipsychotic drug level increased | 14.46 | 10.56 | 26 | 68569 | 3140 | 29880743 |
Developmental delay | 14.45 | 10.56 | 21 | 68574 | 2120 | 29881763 |
Foetal arrhythmia | 14.37 | 10.56 | 6 | 68589 | 85 | 29883798 |
Tunnel vision | 14.27 | 10.56 | 10 | 68585 | 415 | 29883468 |
Tubulointerstitial nephritis | 14.24 | 10.56 | 12 | 68583 | 17879 | 29866004 |
Aspergillus infection | 14.23 | 10.56 | 3 | 68592 | 10211 | 29873672 |
Joint hyperextension | 14.20 | 10.56 | 5 | 68590 | 43 | 29883840 |
Renal disorder | 14.15 | 10.56 | 20 | 68575 | 23564 | 29860319 |
Rhinorrhoea | 14.12 | 10.56 | 16 | 68579 | 20738 | 29863145 |
Congenital hydronephrosis | 14.11 | 10.56 | 12 | 68583 | 665 | 29883218 |
Pseudohyponatraemia | 14.06 | 10.56 | 6 | 68589 | 90 | 29883793 |
Congenital skin dimples | 14.06 | 10.56 | 7 | 68588 | 152 | 29883731 |
Tumour lysis syndrome | 13.96 | 10.56 | 6 | 68589 | 12879 | 29871004 |
Food craving | 13.93 | 10.56 | 9 | 68586 | 326 | 29883557 |
Insulin resistance | 13.89 | 10.56 | 11 | 68584 | 551 | 29883332 |
Substance abuser | 13.88 | 10.56 | 6 | 68589 | 93 | 29883790 |
Gambling disorder | 13.83 | 10.56 | 19 | 68576 | 1821 | 29882062 |
Nonspecific reaction | 13.82 | 10.56 | 16 | 68579 | 1290 | 29882593 |
Sexually inappropriate behaviour | 13.81 | 10.56 | 9 | 68586 | 331 | 29883552 |
Dehydration | 13.60 | 10.56 | 200 | 68395 | 123339 | 29760544 |
Large cell lung cancer metastatic | 13.55 | 10.56 | 4 | 68591 | 18 | 29883865 |
General physical health deterioration | 13.51 | 10.56 | 155 | 68440 | 99789 | 29784094 |
Hypotension | 13.47 | 10.56 | 353 | 68242 | 200212 | 29683671 |
Panic disorder | 13.47 | 10.56 | 15 | 68580 | 1160 | 29882723 |
Flight of ideas | 13.41 | 10.56 | 9 | 68586 | 348 | 29883535 |
Central nervous system inflammation | 13.38 | 10.56 | 6 | 68589 | 102 | 29883781 |
Nervousness | 13.36 | 10.56 | 58 | 68537 | 11730 | 29872153 |
Food interaction | 13.31 | 10.56 | 13 | 68582 | 862 | 29883021 |
Clostridium difficile infection | 13.30 | 10.56 | 10 | 68585 | 15773 | 29868110 |
Urine output decreased | 13.27 | 10.56 | 3 | 68592 | 9726 | 29874157 |
Coma scale abnormal | 13.27 | 10.56 | 26 | 68569 | 3350 | 29880533 |
Double stranded DNULL antibody positive | 13.22 | 10.56 | 6 | 68589 | 105 | 29883778 |
Foetal damage | 13.17 | 10.56 | 3 | 68592 | 3 | 29883880 |
Hypoglycaemia | 13.13 | 10.56 | 66 | 68529 | 50915 | 29832968 |
Heart rate increased | 13.09 | 10.56 | 141 | 68454 | 38580 | 29845303 |
Toxicologic test abnormal | 13.05 | 10.56 | 11 | 68584 | 602 | 29883281 |
Hepatocellular carcinoma | 13.03 | 10.56 | 3 | 68592 | 9607 | 29874276 |
Inhibitory drug interaction | 13.02 | 10.56 | 17 | 68578 | 1551 | 29882332 |
Productive cough | 12.99 | 10.56 | 31 | 68564 | 29922 | 29853961 |
Inflammation | 12.90 | 10.56 | 19 | 68576 | 22007 | 29861876 |
Hypertensive urgency | 12.87 | 10.56 | 5 | 68590 | 58 | 29883825 |
Skull fractured base | 12.85 | 10.56 | 7 | 68588 | 184 | 29883699 |
Conjunctivitis viral | 12.72 | 10.56 | 5 | 68590 | 60 | 29883823 |
Blepharospasm | 12.69 | 10.56 | 13 | 68582 | 913 | 29882970 |
Implant site infection | 12.66 | 10.56 | 13 | 68582 | 916 | 29882967 |
Leukopenia | 12.65 | 10.56 | 76 | 68519 | 56083 | 29827800 |
Pneumonia bacterial | 12.62 | 10.56 | 3 | 68592 | 9400 | 29874483 |
Pericardial effusion | 12.62 | 10.56 | 18 | 68577 | 21126 | 29862757 |
Sclerodactylia | 12.60 | 10.56 | 4 | 68591 | 24 | 29883859 |
Neonatal hypotension | 12.59 | 10.56 | 6 | 68589 | 118 | 29883765 |
Attention deficit hyperactivity disorder | 12.47 | 10.56 | 18 | 68577 | 1806 | 29882077 |
Renal tubular necrosis | 12.43 | 10.56 | 10 | 68585 | 15241 | 29868642 |
Small intestinal obstruction | 12.38 | 10.56 | 8 | 68587 | 13651 | 29870232 |
Haemangioma congenital | 12.37 | 10.56 | 10 | 68585 | 516 | 29883367 |
Diverticulitis | 12.36 | 10.56 | 13 | 68582 | 17432 | 29866451 |
Alcoholic liver disease | 12.36 | 10.56 | 11 | 68584 | 648 | 29883235 |
Hypokalaemia | 12.35 | 10.56 | 66 | 68529 | 50126 | 29833757 |
Convulsive threshold lowered | 12.32 | 10.56 | 10 | 68585 | 519 | 29883364 |
Hypersomnia | 12.31 | 10.56 | 55 | 68540 | 11261 | 29872622 |
Pain in extremity | 12.28 | 10.56 | 178 | 68417 | 110043 | 29773840 |
Myocardial infarction | 12.28 | 10.56 | 208 | 68387 | 125417 | 29758466 |
Hepatocellular injury | 12.25 | 10.56 | 100 | 68495 | 25371 | 29858512 |
Haemorrhage | 12.24 | 10.56 | 59 | 68536 | 46020 | 29837863 |
Dysphemia | 12.21 | 10.56 | 16 | 68579 | 1465 | 29882418 |
Mental disorder | 12.18 | 10.56 | 62 | 68533 | 13387 | 29870496 |
Substance dependence | 12.16 | 10.56 | 9 | 68586 | 407 | 29883476 |
Cogwheel rigidity | 12.16 | 10.56 | 14 | 68581 | 1122 | 29882761 |
Neoplasm progression | 12.14 | 10.56 | 14 | 68581 | 18009 | 29865874 |
Psoriasis | 12.14 | 10.56 | 53 | 68542 | 42453 | 29841430 |
Ex-drug abuser | 12.10 | 10.56 | 7 | 68588 | 207 | 29883676 |
Parkinsonian rest tremor | 12.10 | 10.56 | 6 | 68589 | 129 | 29883754 |
Limited symptom panic attack | 12.09 | 10.56 | 5 | 68590 | 69 | 29883814 |
Muscle tightness | 12.09 | 10.56 | 30 | 68565 | 4533 | 29879350 |
Neutrophil count decreased | 12.08 | 10.56 | 53 | 68542 | 42401 | 29841482 |
Haemoptysis | 12.07 | 10.56 | 34 | 68561 | 31044 | 29852839 |
Accidental death | 12.06 | 10.56 | 19 | 68576 | 2060 | 29881823 |
Self esteem decreased | 12.04 | 10.56 | 10 | 68585 | 536 | 29883347 |
Immune reconstitution inflammatory syndrome | 12.03 | 10.56 | 3 | 68592 | 9098 | 29874785 |
Saccadic eye movement | 12.02 | 10.56 | 6 | 68589 | 131 | 29883752 |
Toxic epidermal necrolysis | 12.02 | 10.56 | 14 | 68581 | 17926 | 29865957 |
Squamous cell carcinoma of skin | 12.02 | 10.56 | 3 | 68592 | 9092 | 29874791 |
Cerebellar syndrome | 11.97 | 10.56 | 19 | 68576 | 2073 | 29881810 |
Magical thinking | 11.96 | 10.56 | 3 | 68592 | 6 | 29883877 |
C-reactive protein increased | 11.94 | 10.56 | 55 | 68540 | 43418 | 29840465 |
Vertebral foraminal stenosis | 11.93 | 10.56 | 10 | 68585 | 543 | 29883340 |
COVID-19 | 11.93 | 10.56 | 14 | 68581 | 17864 | 29866019 |
Pulmonary eosinophilia | 11.92 | 10.56 | 7 | 68588 | 213 | 29883670 |
Foetal heart rate disorder | 11.83 | 10.56 | 4 | 68591 | 30 | 29883853 |
Adrenocorticotropic hormone deficiency | 11.75 | 10.56 | 9 | 68586 | 429 | 29883454 |
Tryptase increased | 11.75 | 10.56 | 7 | 68588 | 219 | 29883664 |
Drug abuser | 11.73 | 10.56 | 29 | 68566 | 4372 | 29879511 |
Delayed fontanelle closure | 11.72 | 10.56 | 4 | 68591 | 31 | 29883852 |
Hypersensitivity | 11.71 | 10.56 | 74 | 68521 | 53954 | 29829929 |
Bacteraemia | 11.71 | 10.56 | 11 | 68584 | 15549 | 29868334 |
Sinus tachycardia | 11.70 | 10.56 | 68 | 68527 | 15436 | 29868447 |
Central nervous system stimulation | 11.65 | 10.56 | 3 | 68592 | 7 | 29883876 |
Blood potassium increased | 11.58 | 10.56 | 12 | 68583 | 16201 | 29867682 |
Nasopharyngitis | 11.56 | 10.56 | 83 | 68512 | 58766 | 29825117 |
Dyspnoea exertional | 11.49 | 10.56 | 42 | 68553 | 35388 | 29848495 |
Exposure via breast milk | 11.47 | 10.56 | 16 | 68579 | 1556 | 29882327 |
Candida infection | 11.40 | 10.56 | 11 | 68584 | 15351 | 29868532 |
Impulse-control disorder | 11.39 | 10.56 | 15 | 68580 | 1380 | 29882503 |
Psychomotor skills impaired | 11.36 | 10.56 | 18 | 68577 | 1961 | 29881922 |
Naevus flammeus | 11.36 | 10.56 | 6 | 68589 | 148 | 29883735 |
Flashback | 11.36 | 10.56 | 6 | 68589 | 148 | 29883735 |
Craniocerebral injury | 11.35 | 10.56 | 22 | 68573 | 2811 | 29881072 |
Coronary artery disease | 11.34 | 10.56 | 67 | 68528 | 49645 | 29834238 |
Alcohol poisoning | 11.33 | 10.56 | 26 | 68569 | 3738 | 29880145 |
Congenital mitral valve incompetence | 11.31 | 10.56 | 5 | 68590 | 82 | 29883801 |
Narcolepsy | 11.29 | 10.56 | 9 | 68586 | 455 | 29883428 |
Hepatotoxicity | 11.28 | 10.56 | 15 | 68580 | 18130 | 29865753 |
Oromandibular dystonia | 11.27 | 10.56 | 9 | 68586 | 456 | 29883427 |
Sexual activity increased | 11.20 | 10.56 | 4 | 68591 | 36 | 29883847 |
Chronic obstructive pulmonary disease | 11.15 | 10.56 | 61 | 68534 | 46065 | 29837818 |
Enterocolitis bacterial | 11.12 | 10.56 | 7 | 68588 | 242 | 29883641 |
Newborn persistent pulmonary hypertension | 11.05 | 10.56 | 5 | 68590 | 87 | 29883796 |
Angioedema | 11.00 | 10.56 | 41 | 68554 | 34343 | 29849540 |
Hypotonia | 11.00 | 10.56 | 38 | 68557 | 6910 | 29876973 |
Blood pressure decreased | 10.98 | 10.56 | 63 | 68532 | 47012 | 29836871 |
Cerebellar haematoma | 10.95 | 10.56 | 7 | 68588 | 249 | 29883634 |
Necrotising ulcerative gingivostomatitis | 10.94 | 10.56 | 5 | 68590 | 89 | 29883794 |
Hiccups | 10.86 | 10.56 | 4 | 68591 | 9430 | 29874453 |
Skin exfoliation | 10.84 | 10.56 | 23 | 68572 | 23149 | 29860734 |
Lip swelling | 10.84 | 10.56 | 8 | 68587 | 12736 | 29871147 |
Suspected suicide | 10.83 | 10.56 | 23 | 68572 | 3138 | 29880745 |
Full blood count decreased | 10.82 | 10.56 | 12 | 68583 | 15705 | 29868178 |
Feeling of despair | 10.77 | 10.56 | 12 | 68583 | 928 | 29882955 |
Libido disorder | 10.75 | 10.56 | 7 | 68588 | 257 | 29883626 |
Urinary hesitation | 10.74 | 10.56 | 19 | 68576 | 2265 | 29881618 |
Imprisonment | 10.73 | 10.56 | 9 | 68586 | 489 | 29883394 |
Generalised oedema | 10.72 | 10.56 | 7 | 68588 | 11878 | 29872005 |
Upper respiratory tract infection | 10.71 | 10.56 | 30 | 68565 | 27446 | 29856437 |
Asphyxia | 10.70 | 10.56 | 32 | 68563 | 5393 | 29878490 |
Foetal hypokinesia | 10.68 | 10.56 | 8 | 68587 | 369 | 29883514 |
Gonadotrophin deficiency | 10.65 | 10.56 | 4 | 68591 | 42 | 29883841 |
Spondylolisthesis | 10.58 | 10.56 | 11 | 68584 | 786 | 29883097 |
Source | Code | Description |
---|---|---|
ATC | N06AX16 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
FDA EPC | N0000175749 | Serotonin and Norepinephrine Reuptake Inhibitor |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D000068760 | Serotonin and Noradrenaline Reuptake Inhibitors |
CHEBI has role | CHEBI:35469 | thymoanaleptics |
CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:50949 | serotonin reuptake inhibitor |
CHEBI has role | CHEBI:51039 | dopamine reuptake inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Social phobia | indication | 25501002 | DOID:11257 |
Major depressive disorder | indication | 370143000 | |
Panic disorder | indication | 371631005 | DOID:594 |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Menopausal flushing | off-label use | 198436008 | |
Neuropathic pain | off-label use | 247398009 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Hypercholesterolemia | contraindication | 13644009 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Substance abuse | contraindication | 66214007 | |
Weight loss | contraindication | 89362005 | |
Hyponatremia | contraindication | 89627008 | |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Bleeding | contraindication | 131148009 | |
Impaired renal function disorder | contraindication | 197663003 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Interstitial lung disease | contraindication | 233703007 | DOID:3082 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypertriglyceridemia | contraindication | 302870006 | |
Serotonin syndrome | contraindication | 371089000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Hypertensive urgency | contraindication | 443482000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.33 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Kd | 5.97 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 8.05 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.65 | PDSP | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.55 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.44 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.70 | PDSP | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 7.05 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.44 | CHEMBL | |||||
Transporter | Transporter | IC50 | 6.19 | CHEMBL | |||||
Transporter | Transporter | Ki | 6.86 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 7.60 | CHEMBL |
ID | Source |
---|---|
4023901 | VUID |
N0000021906 | NUI |
D00821 | KEGG_DRUG |
99300-78-4 | SECONDARY_CAS_RN |
4020846 | VANDF |
4023901 | VANDF |
C0591437 | UMLSCUI |
CHEBI:9943 | CHEBI |
CHEMBL637 | ChEMBL_ID |
CHEMBL1201066 | ChEMBL_ID |
D000069470 | MESH_DESCRIPTOR_UI |
5656 | PUBCHEM_CID |
6358 | INN_ID |
DB00285 | DRUGBANK_ID |
GRZ5RCB1QG | UNII |
7321 | IUPHAR_LIGAND_ID |
151692 | RXNORM |
5669 | MMSL |
594 | MMSL |
87651 | MMSL |
d03181 | MMSL |
004428 | NDDF |
004429 | NDDF |
108432009 | SNOMEDCT_US |
108434005 | SNOMEDCT_US |
372490001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Effexor XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-0833 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | NDA | 35 sections |
Effexor XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-0836 | CAPSULE, EXTENDED RELEASE | 150 mg | ORAL | NDA | 35 sections |
Effexor XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-0837 | CAPSULE, EXTENDED RELEASE | 37.50 mg | ORAL | NDA | 35 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7384 | CAPSULE, EXTENDED RELEASE | 37.50 mg | ORAL | ANDA | 32 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7385 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 32 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7386 | CAPSULE, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 32 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-9147 | TABLET | 25 mg | ORAL | ANDA | 34 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-9148 | TABLET | 37.50 mg | ORAL | ANDA | 34 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-9149 | TABLET | 50 mg | ORAL | ANDA | 34 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-9157 | TABLET | 75 mg | ORAL | ANDA | 34 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-9163 | TABLET | 100 mg | ORAL | ANDA | 34 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2604 | TABLET | 150 mg | ORAL | ANDA | 29 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2605 | TABLET | 225 mg | ORAL | ANDA | 29 sections |
Venlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2606 | TABLET | 75 mg | ORAL | ANDA | 29 sections |
Venlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-6566 | TABLET | 37.50 mg | ORAL | ANDA | 25 sections |
Venlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-6567 | TABLET | 75 mg | ORAL | ANDA | 23 sections |
Venlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7557 | TABLET | 50 mg | ORAL | ANDA | 23 sections |
Venlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7558 | TABLET | 100 mg | ORAL | ANDA | 23 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7621 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 32 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7622 | CAPSULE, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 32 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8122 | TABLET | 75 mg | ORAL | ANDA | 34 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8346 | TABLET | 75 mg | ORAL | ANDA | 34 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6468 | CAPSULE, EXTENDED RELEASE | 37.50 mg | ORAL | ANDA | 31 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6469 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 31 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6470 | CAPSULE, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 31 sections |
VENLAFAXINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-018 | CAPSULE, EXTENDED RELEASE | 37.50 mg | ORAL | ANDA | 31 sections |
VENLAFAXINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-019 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 31 sections |
VENLAFAXINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-020 | CAPSULE, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 31 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-712 | TABLET, EXTENDED RELEASE | 37.50 mg | ORAL | NDA AUTHORIZED GENERIC | 29 sections |
Venlafaxine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-713 | TABLET, EXTENDED RELEASE | 75 mg | ORAL | NDA AUTHORIZED GENERIC | 29 sections |