valproic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2803 99-66-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • divalproex disodium
  • valproic acid
  • 2-Propylpentanoic acid
  • dipropylacetic acid
  • epival
  • divalproex sodium
  • depakote
  • valdisoval
  • valproate semisodium
  • valproate sodium
  • sodium valproate
  • divalproex
  • propylisopropylacetic acid
  • magnesium valproate
  • valproate calcium
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
  • Molecular weight: 144.21
  • Formula: C8H16O2
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.79
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P
1.50 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 289.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.16 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1978 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1933.40 11.05 1783 121538 130851 63234850
Drug interaction 1256.14 11.05 1862 121459 227269 63138432
Hyperammonaemia 1198.76 11.05 432 122889 4800 63360901
Hyperammonaemic encephalopathy 1093.23 11.05 334 122987 2100 63363601
Status epilepticus 918.70 11.05 491 122830 14742 63350959
Somnolence 729.33 11.05 1271 122050 177414 63188287
Foetal anticonvulsant syndrome 667.00 11.05 168 123153 437 63365264
Toxicity to various agents 648.62 11.05 1461 121860 245789 63119912
Sopor 612.50 11.05 434 122887 21730 63343971
Epilepsy 606.27 11.05 467 122854 26598 63339103
Multiple-drug resistance 599.56 11.05 261 123060 4909 63360792
Aggression 560.59 11.05 421 122900 23077 63342624
Psychotic disorder 548.44 11.05 431 122890 25281 63340420
Pain 542.72 11.05 391 122930 740237 62625464
Arthralgia 527.97 11.05 224 123097 569486 62796215
Generalised tonic-clonic seizure 504.77 11.05 432 122889 28584 63337117
Dysmorphism 493.90 11.05 181 123140 2115 63363586
Drug level increased 491.14 11.05 384 122937 22352 63343349
Extrapyramidal disorder 449.86 11.05 295 123026 12989 63352712
Foetal exposure during pregnancy 449.39 11.05 422 122899 31540 63334161
Intentional overdose 446.15 11.05 631 122690 73521 63292180
Coma 445.16 11.05 586 122735 63778 63301923
Ammonia increased 440.87 11.05 204 123117 4452 63361249
Joint swelling 429.09 11.05 63 123258 327603 63038098
Tremor 425.49 11.05 850 122471 131389 63234312
Overdose 422.11 11.05 782 122539 114296 63251405
Mania 414.80 11.05 273 123048 12094 63353607
Rheumatoid arthritis 397.37 11.05 24 123297 253795 63111906
Petit mal epilepsy 383.62 11.05 174 123147 3620 63362081
Sedation 372.14 11.05 417 122904 38392 63327309
Infusion related reaction 364.73 11.05 30 123291 245491 63120210
Neuroleptic malignant syndrome 363.25 11.05 249 123072 11807 63353894
Granulocytopenia 356.50 11.05 188 123133 5484 63360217
Schizoaffective disorder 355.86 11.05 162 123159 3400 63362301
Speech disorder developmental 355.81 11.05 105 123216 575 63365126
Intentional self-injury 353.14 11.05 335 122986 25352 63340349
Arthropathy 350.67 11.05 28 123293 234764 63130937
Parkinsonism 341.76 11.05 227 123094 10212 63355489
Drug abuse 340.73 11.05 550 122771 71968 63293733
Drug reaction with eosinophilia and systemic symptoms 335.48 11.05 370 122951 33466 63332235
Suicide attempt 332.30 11.05 495 122826 60423 63305278
Fatigue 320.80 11.05 791 122530 887237 62478464
Electrocardiogram QT prolonged 315.12 11.05 477 122844 59053 63306648
Agitation 310.92 11.05 475 122846 59282 63306419
Depressed level of consciousness 306.98 11.05 482 122839 61596 63304105
Abdominal discomfort 306.62 11.05 120 123201 320765 63044936
Abnormal behaviour 305.19 11.05 285 123036 21141 63344560
Swelling 299.95 11.05 82 123239 275296 63090405
Developmental delay 297.25 11.05 111 123210 1372 63364329
Hand deformity 288.71 11.05 4 123317 159453 63206248
Dyspnoea 286.78 11.05 531 122790 660782 62704919
Peripheral swelling 286.26 11.05 81 123240 265861 63099840
Ataxia 276.03 11.05 232 123089 14963 63350738
Systemic lupus erythematosus 276.00 11.05 39 123282 208879 63156822
Contraindicated product administered 273.09 11.05 47 123274 217601 63148100
Glossodynia 270.79 11.05 20 123301 178856 63186845
Learning disorder 269.71 11.05 85 123236 600 63365101
Schizophrenia 256.83 11.05 187 123134 9765 63355936
Intellectual disability 249.95 11.05 90 123231 996 63364705
Antipsychotic drug level increased 242.18 11.05 123 123198 3312 63362389
Cognitive disorder 238.85 11.05 406 122915 55409 63310292
Anticonvulsant drug level increased 237.94 11.05 95 123226 1422 63364279
Autism spectrum disorder 234.17 11.05 81 123240 789 63364912
Drug level decreased 230.18 11.05 160 123161 7759 63357942
Discomfort 228.81 11.05 28 123293 167346 63198355
Salivary hypersecretion 225.44 11.05 156 123165 7510 63358191
Abortion spontaneous 221.67 11.05 358 122963 46837 63318864
Myoclonic epilepsy 219.42 11.05 85 123236 1169 63364532
Diarrhoea 219.22 11.05 689 122632 714677 62651024
Sinusitis 214.32 11.05 86 123235 226567 63139134
Nasopharyngitis 210.40 11.05 116 123205 254141 63111560
Hypernatraemia 210.15 11.05 149 123172 7460 63358241
Encephalopathy 205.09 11.05 310 123011 38310 63327391
Drug intolerance 204.89 11.05 179 123142 308482 63057219
Irritability 204.37 11.05 279 123042 31415 63334286
Altered state of consciousness 203.29 11.05 248 123073 24982 63340719
Hypersensitivity 201.30 11.05 164 123157 292521 63073180
Hallucination, auditory 197.05 11.05 178 123143 12646 63353055
Hypomania 196.04 11.05 133 123188 6197 63359504
Disturbance in attention 194.98 11.05 301 123020 37888 63327813
Anticonvulsant drug level decreased 191.50 11.05 77 123244 1175 63364526
Hypothermia 188.31 11.05 178 123143 13403 63352298
Drug ineffective for unapproved indication 187.41 11.05 278 123043 33785 63331916
Drug resistance 187.34 11.05 227 123094 22706 63342995
Sudden unexplained death in epilepsy 187.22 11.05 54 123267 269 63365432
Anticonvulsant drug level above therapeutic 184.74 11.05 60 123261 472 63365229
Behaviour disorder 184.09 11.05 100 123221 3099 63362602
Partial seizures 183.92 11.05 124 123197 5718 63359983
Disorientation 183.54 11.05 298 123023 39154 63326547
Catatonia 177.87 11.05 110 123211 4367 63361334
Delusion 177.21 11.05 163 123158 11854 63353847
Fanconi syndrome 176.94 11.05 75 123246 1317 63364384
Stevens-Johnson syndrome 176.77 11.05 230 123091 24720 63340981
Psychomotor retardation 171.55 11.05 102 123219 3768 63361933
Psychomotor skills impaired 170.47 11.05 86 123235 2282 63363419
Pain in extremity 169.68 11.05 238 123083 331248 63034453
Hypotonia 169.12 11.05 142 123179 9143 63356558
Treatment noncompliance 166.97 11.05 277 123044 37048 63328653
Wound 166.04 11.05 55 123266 163208 63202493
Electroencephalogram abnormal 163.34 11.05 97 123224 3575 63362126
Bipolar disorder 158.06 11.05 128 123193 7832 63357869
Therapeutic product effect decreased 157.08 11.05 90 123231 193097 63172604
Learning disability 153.47 11.05 43 123278 189 63365512
Nausea 153.33 11.05 1003 122318 853468 62512233
Suicidal ideation 153.26 11.05 360 122961 62061 63303640
Pericarditis 151.19 11.05 35 123286 131544 63234157
Respiratory depression 149.98 11.05 158 123163 13557 63352144
Congenital nose malformation 149.45 11.05 45 123276 267 63365434
Drug withdrawal convulsions 149.29 11.05 67 123254 1358 63364343
Pruritus 148.52 11.05 299 123022 361154 63004547
Language disorder 148.37 11.05 76 123245 2084 63363617
Headache 144.66 11.05 686 122635 632555 62733146
Psychomotor hyperactivity 142.60 11.05 137 123184 10526 63355175
Helicobacter infection 141.43 11.05 10 123311 92775 63272926
Product substitution issue 139.97 11.05 164 123157 15832 63349869
Mental disorder 138.95 11.05 209 123112 25710 63339991
Myoclonus 137.71 11.05 162 123159 15706 63349995
Back pain 135.75 11.05 189 123132 263956 63101745
Muscle rigidity 135.69 11.05 138 123183 11362 63354339
Pneumonia aspiration 135.68 11.05 242 123079 34298 63331403
Cough 135.50 11.05 225 123096 292518 63073183
Paradoxical drug reaction 135.20 11.05 90 123231 4062 63361639
Educational problem 133.75 11.05 44 123277 362 63365339
Dysarthria 131.72 11.05 270 123051 42441 63323260
Impaired healing 131.06 11.05 21 123300 102521 63263180
Completed suicide 129.85 11.05 594 122727 145079 63220622
Anticonvulsant drug level below therapeutic 125.05 11.05 47 123274 592 63365109
Folliculitis 122.20 11.05 3 123318 70314 63295387
Blood creatine phosphokinase increased 120.54 11.05 214 123107 30216 63335485
Thrombocytopenia 119.95 11.05 596 122725 150561 63215140
Arthritis 119.70 11.05 38 123283 115883 63249818
Bradyphrenia 119.45 11.05 103 123218 6877 63358824
Meningomyelocele 119.29 11.05 45 123276 573 63365128
Rhabdomyolysis 118.41 11.05 263 123058 43688 63322013
Intentional product use issue 116.83 11.05 51 123270 127841 63237860
Exposure during pregnancy 116.20 11.05 603 122718 154944 63210757
Tardive dyskinesia 115.14 11.05 110 123211 8392 63357309
Psychogenic seizure 114.67 11.05 59 123262 1633 63364068
Alopecia 114.67 11.05 309 123012 337227 63028474
Nystagmus 113.02 11.05 95 123226 6125 63359576
Congenital hand malformation 112.68 11.05 36 123285 267 63365434
Stomatitis 112.20 11.05 65 123256 138660 63227041
Congenital foot malformation 111.49 11.05 34 123287 212 63365489
Rash 110.89 11.05 638 122683 560233 62805468
Febrile neutropenia 108.56 11.05 47 123274 118402 63247299
Akathisia 108.36 11.05 110 123211 9036 63356665
Talipes 108.14 11.05 55 123266 1485 63364216
Carnitine deficiency 105.96 11.05 30 123291 138 63365563
Myocarditis 105.93 11.05 115 123206 10210 63355491
Hyperprolactinaemia 104.54 11.05 75 123246 3825 63361876
Infection 104.28 11.05 178 123143 228995 63136706
Speech disorder 103.74 11.05 238 123083 40391 63325310
Product residue present 103.19 11.05 75 123246 3904 63361797
Propofol infusion syndrome 102.28 11.05 46 123275 937 63364764
Cerebral atrophy 101.72 11.05 82 123239 4984 63360717
Injection site pain 100.52 11.05 64 123257 129736 63235965
Atonic seizures 100.16 11.05 40 123281 599 63365102
Psoriatic arthropathy 99.98 11.05 27 123294 91493 63274208
Leukopenia 99.96 11.05 354 122967 76936 63288765
Osteoarthritis 98.88 11.05 31 123290 95312 63270389
Abdominal pain upper 97.96 11.05 156 123165 206288 63159413
Psychiatric symptom 97.44 11.05 81 123240 5142 63360559
Loss of consciousness 94.56 11.05 467 122854 117654 63248047
Muscle injury 94.17 11.05 9 123312 65336 63300365
Stupor 94.01 11.05 73 123248 4202 63361499
Blood prolactin increased 93.06 11.05 67 123254 3436 63362265
Musculoskeletal stiffness 92.90 11.05 134 123187 184484 63181217
Toxic encephalopathy 92.68 11.05 87 123234 6492 63359209
Persecutory delusion 92.11 11.05 61 123260 2729 63362972
Dyskinesia 91.32 11.05 196 123125 31806 63333895
Herpes zoster 90.69 11.05 24 123297 82438 63283263
Delirium 89.57 11.05 258 123063 50283 63315418
Focal dyscognitive seizures 89.56 11.05 61 123260 2860 63362841
Lethargy 88.93 11.05 275 123046 55732 63309969
Low set ears 87.90 11.05 29 123292 241 63365460
Urticaria 87.78 11.05 116 123205 165686 63200015
Hypertelorism 86.45 11.05 33 123288 435 63365266
Toxic epidermal necrolysis 86.33 11.05 167 123154 25167 63340534
Motor developmental delay 85.00 11.05 25 123296 135 63365566
COVID-19 84.55 11.05 58 123263 113045 63252656
Hyperlactacidaemia 83.82 11.05 58 123263 2791 63362910
Irritable bowel syndrome 83.33 11.05 28 123293 82384 63283317
Gastrointestinal disorder 82.33 11.05 80 123241 131159 63234542
Gingival hypertrophy 81.88 11.05 47 123274 1624 63364077
Neuropathy peripheral 81.43 11.05 61 123260 113606 63252095
Paranoia 80.14 11.05 106 123215 11573 63354128
Knee arthroplasty 79.35 11.05 7 123314 54199 63311502
Tonic convulsion 78.70 11.05 42 123279 1255 63364446
Arnold-Chiari malformation 78.49 11.05 34 123287 631 63365070
Chest pain 77.64 11.05 192 123129 215767 63149934
Abortion induced 76.59 11.05 97 123224 10145 63355556
Anaemia 76.44 11.05 302 123019 293128 63072573
Bipolar I disorder 76.31 11.05 47 123274 1852 63363849
Strabismus 76.26 11.05 48 123273 1966 63363735
Injection site erythema 76.21 11.05 33 123288 83141 63282560
Impulsive behaviour 76.16 11.05 44 123277 1539 63364162
Hallucinations, mixed 76.10 11.05 68 123253 4761 63360940
Mental impairment 75.68 11.05 114 123207 14037 63351664
Hypoaesthesia 74.56 11.05 133 123188 168260 63197441
Pleurothotonus 74.39 11.05 41 123280 1308 63364393
Seizure cluster 74.22 11.05 25 123296 223 63365478
Lower respiratory tract infection 73.73 11.05 89 123232 132218 63233483
Spina bifida 73.19 11.05 35 123286 824 63364877
Microcephaly 73.16 11.05 36 123285 904 63364797
Ear malformation 72.89 11.05 24 123297 198 63365503
Dystonia 72.03 11.05 110 123211 13709 63351992
Anger 71.88 11.05 104 123217 12352 63353349
Product dose omission issue 71.84 11.05 225 123096 234088 63131613
Mitochondrial DNA mutation 71.69 11.05 28 123293 394 63365307
Affect lability 71.62 11.05 98 123223 11053 63354648
Communication disorder 71.46 11.05 50 123271 2450 63363251
Hepatic function abnormal 71.10 11.05 195 123126 36947 63328754
Atrial septal defect 70.69 11.05 77 123244 6861 63358840
Oculogyric crisis 70.19 11.05 43 123278 1678 63364023
Enuresis 70.16 11.05 50 123271 2523 63363178
Cardiac failure congestive 69.62 11.05 47 123274 92386 63273315
Ileus paralytic 69.58 11.05 63 123258 4488 63361213
Confusional state 68.86 11.05 732 122589 235648 63130053
Inflammation 68.74 11.05 37 123284 82236 63283465
Neutropenia 68.45 11.05 577 122744 174428 63191273
Dyspraxia 68.29 11.05 24 123297 246 63365455
C-reactive protein abnormal 67.35 11.05 6 123315 46090 63319611
Poisoning 67.14 11.05 106 123215 13594 63352107
Neovascularisation 66.46 11.05 36 123285 1109 63364592
Fibromyalgia 65.98 11.05 37 123284 80383 63285318
Infantile spasms 65.63 11.05 22 123299 193 63365508
Antipsychotic drug level decreased 65.59 11.05 25 123296 328 63365373
Congenital eyelid malformation 65.50 11.05 13 123308 3 63365698
Resting tremor 65.49 11.05 32 123289 791 63364910
Stillbirth 65.47 11.05 73 123248 6677 63359024
Metabolic encephalopathy 65.44 11.05 68 123253 5741 63359960
Restlessness 64.92 11.05 163 123158 29290 63336411
Attention deficit hyperactivity disorder 64.34 11.05 51 123270 3025 63362676
Malignant neoplasm progression 64.24 11.05 40 123281 82081 63283620
Metabolic acidosis 64 11.05 213 123108 44856 63320845
Blister 63.54 11.05 96 123225 129718 63235983
Intra-abdominal pressure increased 62.47 11.05 22 123299 227 63365474
General physical health deterioration 62.00 11.05 193 123128 201209 63164492
Weight increased 61.83 11.05 776 122545 260016 63105685
Musculoskeletal pain 61.73 11.05 53 123268 92224 63273477
Brain oedema 61.66 11.05 104 123217 14091 63351610
Mental status changes 61.53 11.05 193 123128 39406 63326295
Acute hepatic failure 61.45 11.05 120 123201 18207 63347494
Hepatic failure 60.28 11.05 179 123142 35477 63330224
Encephalitis autoimmune 60.28 11.05 37 123284 1449 63364252
Rhinorrhoea 60.10 11.05 26 123295 65551 63300150
Hepatic enzyme increased 59.42 11.05 198 123123 202130 63163571
Dementia 59.34 11.05 120 123201 18674 63347027
Contusion 59.06 11.05 127 123194 149917 63215784
Influenza 58.62 11.05 75 123246 108647 63257054
Grandiosity 58.47 11.05 22 123299 278 63365423
Blood pressure increased 58.29 11.05 144 123177 161918 63203783
Hip arthroplasty 58.15 11.05 11 123310 47635 63318066
Astigmatism 57.66 11.05 32 123289 1035 63364666
Acidosis hyperchloraemic 57.43 11.05 24 123297 406 63365295
Plasma cell myeloma 57.32 11.05 3 123318 35902 63329799
Hirsutism 57.26 11.05 35 123286 1360 63364341
Hypertonia 57.19 11.05 57 123264 4580 63361121
Nasal congestion 57.12 11.05 28 123293 65632 63300069
Drug level below therapeutic 56.69 11.05 58 123263 4808 63360893
Cerebellar atrophy 56.30 11.05 28 123293 720 63364981
Suicidal behaviour 55.73 11.05 44 123277 2595 63363106
Hyponatraemia 55.48 11.05 390 122931 111510 63254191
Drug hypersensitivity 55.18 11.05 365 122956 310322 63055379
Hyperthermia 55.11 11.05 78 123243 9078 63356623
White blood cell count increased 54.88 11.05 213 123108 48348 63317353
Retinogram abnormal 54.20 11.05 18 123303 153 63365548
Personal relationship issue 54.08 11.05 15 123306 63 63365638
Hallucination 53.67 11.05 230 123091 54587 63311114
Productive cough 53.42 11.05 28 123293 63180 63302521
Hypertension 52.22 11.05 323 122998 278980 63086721
Obsessive-compulsive disorder 52.10 11.05 51 123270 4009 63361692
Differential white blood cell count abnormal 52.09 11.05 27 123294 759 63364942
Dyspnoea exertional 52.03 11.05 26 123295 60276 63305425
Hypokinesia 51.36 11.05 95 123226 13841 63351860
Tonic clonic movements 51.35 11.05 33 123288 1402 63364299
Fluid retention 51.10 11.05 26 123295 59660 63306041
Neutrophil count increased 50.37 11.05 104 123217 16423 63349278
Dyslexia 50.05 11.05 20 123301 300 63365401
Psoriasis 50.04 11.05 57 123264 86900 63278801
Thrombosis 50.01 11.05 32 123289 64723 63300978
Arachnodactyly 49.96 11.05 15 123306 88 63365613
Blood pressure systolic increased 49.87 11.05 15 123306 47382 63318319
Myopia 49.41 11.05 34 123287 1621 63364080
Injection site reaction 49.35 11.05 26 123295 58498 63307203
Neurodevelopmental disorder 49.29 11.05 17 123304 164 63365537
Asthma-chronic obstructive pulmonary disease overlap syndrome 49.29 11.05 37 123284 2024 63363677
Flushing 49.16 11.05 44 123277 75043 63290658
Disease progression 49.06 11.05 103 123218 122655 63243046
Bronchitis 48.95 11.05 106 123215 124829 63240872
Lip disorder 48.11 11.05 32 123289 1442 63364259
Hallucination, visual 48.10 11.05 112 123209 19186 63346515
Bone pain 47.99 11.05 23 123298 54618 63311083
Dysgraphia 47.80 11.05 44 123277 3202 63362499
Angiofibroma 47.58 11.05 15 123306 106 63365595
Death 47.22 11.05 482 122839 373899 62991802
Ventricular septal defect 47.09 11.05 50 123271 4328 63361373
Necrosis ischaemic 47.04 11.05 26 123295 834 63364867
Lordosis 47.01 11.05 19 123302 294 63365407
Selective eating disorder 46.91 11.05 36 123285 2036 63363665
Dry skin 46.91 11.05 26 123295 56861 63308840
Pulmonary fibrosis 46.89 11.05 10 123311 39799 63325902
Reflexes abnormal 46.89 11.05 24 123297 657 63365044
Drop attacks 46.85 11.05 24 123297 658 63365043
Inappropriate antidiuretic hormone secretion 46.78 11.05 97 123224 15365 63350336
Abdominal pain 46.62 11.05 356 122965 293100 63072601
Atrial fibrillation 46.50 11.05 98 123223 116538 63249163
Psychotic symptom 46.44 11.05 32 123289 1529 63364172
Amenorrhoea 46.24 11.05 75 123246 9839 63355862
Clinodactyly 46.18 11.05 15 123306 118 63365583
Dysmetria 46.12 11.05 22 123299 515 63365186
Gastrointestinal haemorrhage 45.86 11.05 54 123267 81122 63284579
Craniosynostosis 45.79 11.05 16 123305 161 63365540
Mobility decreased 45.67 11.05 105 123216 121054 63244647
Affective disorder 45.63 11.05 58 123263 6088 63359613
Total lung capacity increased 45.55 11.05 37 123284 2273 63363428
Unresponsive to stimuli 45.53 11.05 157 123164 33659 63332042
Urinary incontinence 45.18 11.05 151 123170 31863 63333838
Medication overuse headache 45.09 11.05 25 123296 807 63364894
Antipsychotic drug level above therapeutic 44.95 11.05 27 123294 1016 63364685
Malaise 44.79 11.05 555 122766 415399 62950302
Multiple congenital abnormalities 44.51 11.05 22 123299 558 63365143
Ill-defined disorder 44.48 11.05 56 123265 81699 63284002
Injection site pruritus 44.45 11.05 16 123305 45100 63320601
Nephrogenic diabetes insipidus 44.40 11.05 26 123295 933 63364768
Pneumatosis 44.13 11.05 20 123301 415 63365286
Myalgia 43.97 11.05 142 123179 146387 63219314
Hepatotoxicity 43.93 11.05 165 123156 36876 63328825
Night sweats 43.72 11.05 20 123301 48794 63316907
Blood lactic acid increased 43.59 11.05 61 123260 7025 63358676
Depressed mood 43.56 11.05 174 123147 40017 63325684
Coordination abnormal 43.55 11.05 88 123233 13685 63352016
Jaundice cholestatic 43.50 11.05 62 123259 7262 63358439
Bradykinesia 43.42 11.05 52 123269 5136 63360565
Aphasia 43.38 11.05 152 123169 32848 63332853
Delusion of grandeur 43.35 11.05 17 123304 242 63365459
Logorrhoea 42.87 11.05 37 123284 2473 63363228
Depressive symptom 42.62 11.05 46 123275 4056 63361645
Refusal of treatment by patient 42.60 11.05 53 123268 5444 63360257
Asthenia 42.37 11.05 509 122812 383095 62982606
Pectus excavatum 42.37 11.05 13 123308 83 63365618
Gene mutation 42.31 11.05 31 123290 1634 63364067
Bursitis 42.23 11.05 10 123311 37031 63328670
Haematochezia 41.98 11.05 26 123295 53518 63312183
Oral mucosa erosion 41.83 11.05 27 123294 1156 63364545
Injection site swelling 41.82 11.05 20 123301 47552 63318149
Oropharyngeal pain 41.46 11.05 75 123246 94412 63271289
Chills 41.34 11.05 100 123221 113278 63252423
Hot flush 41.30 11.05 24 123297 51135 63314566
Treatment failure 41.02 11.05 223 123098 198820 63166881
Tooth malformation 40.99 11.05 9 123312 9 63365692
Psychotic behaviour 40.89 11.05 21 123300 579 63365122
Chest discomfort 40.88 11.05 96 123225 109873 63255828
Asthma 40.84 11.05 120 123201 127441 63238260
Hypersexuality 40.65 11.05 20 123301 502 63365199
Balance disorder 40.53 11.05 292 123029 84130 63281571
Camptodactyly congenital 40.51 11.05 9 123312 10 63365691
Eosinophilic pleural effusion 40.49 11.05 11 123310 42 63365659
Cataract 40.35 11.05 31 123290 57022 63308679
Mood swings 40.22 11.05 101 123220 18147 63347554
Asterixis 40.03 11.05 28 123293 1371 63364330
Psychiatric decompensation 40.00 11.05 28 123293 1373 63364328
Tachycardia 39.71 11.05 377 122944 117779 63247922
Carnitine decreased 39.43 11.05 8 123313 3 63365698
Injection site bruising 39.39 11.05 16 123305 41894 63323807
Limbic encephalitis 39.32 11.05 17 123304 314 63365387
Wheezing 39.22 11.05 79 123242 95516 63270185
Magnetic resonance imaging head abnormal 39.18 11.05 32 123289 1981 63363720
Sinus rhythm 39.09 11.05 23 123298 833 63364868
Hyperchloraemia 38.83 11.05 22 123299 741 63364960
Pain in jaw 38.67 11.05 18 123303 43478 63322223
Wrong patient received product 38.64 11.05 33 123288 2174 63363527
Plagiocephaly 38.61 11.05 11 123310 52 63365649
Mydriasis 38.53 11.05 77 123244 11879 63353822
Congenital scoliosis 38.10 11.05 11 123310 55 63365646
Blood gases abnormal 37.94 11.05 22 123299 775 63364926
Muscle spasms 37.93 11.05 165 123156 155985 63209716
Red blood cell sedimentation rate increased 37.89 11.05 19 123302 43963 63321738
Joint stiffness 37.73 11.05 17 123304 41852 63323849
Apathy 37.63 11.05 64 123257 8730 63356971
Interstitial lung disease 37.36 11.05 39 123282 61869 63303832
Epistaxis 37.33 11.05 52 123269 72673 63293028
Glycosuria 37.30 11.05 25 123296 1141 63364560
Posture abnormal 37.07 11.05 33 123288 2299 63363402
Galactorrhoea 37.01 11.05 43 123278 4112 63361589
Platelet count decreased 36.80 11.05 366 122955 115756 63249945
Sluggishness 36.42 11.05 48 123273 5221 63360480
Hypermetropia 36.36 11.05 18 123303 458 63365243
Paraesthesia 36.25 11.05 169 123152 156797 63208904
Congenital anomaly 36.19 11.05 29 123292 1747 63363954
Neck pain 36.14 11.05 49 123272 69269 63296432
Rash maculo-papular 36.11 11.05 140 123181 31756 63333945
Macular degeneration 36.08 11.05 3 123318 24373 63341328
Congenital joint malformation 35.95 11.05 8 123313 9 63365692
Partial seizures with secondary generalisation 35.71 11.05 17 123304 396 63365305
Metabolic disorder 35.65 11.05 53 123268 6450 63359251
Cleft palate 35.54 11.05 23 123298 989 63364712
Adjustment disorder with mixed anxiety and depressed mood 35.53 11.05 12 123309 108 63365593
Leukocytosis 35.43 11.05 121 123200 25814 63339887
Polydipsia 35.35 11.05 39 123282 3525 63362176
Change in seizure presentation 35.33 11.05 17 123304 406 63365295
Oropharyngeal oedema 35.26 11.05 16 123305 333 63365368
Anaphylactic reaction 35.20 11.05 46 123275 66054 63299647
Weight gain poor 35.11 11.05 22 123299 894 63364807
Cardiac murmur 34.69 11.05 83 123238 14469 63351232
Anaemia macrocytic 34.61 11.05 38 123283 3416 63362285
Loss of personal independence in daily activities 34.53 11.05 87 123234 97203 63268498
Euphoric mood 34.53 11.05 45 123276 4842 63360859
Throat irritation 34.38 11.05 15 123306 37632 63328069
Respiratory acidosis 34.36 11.05 53 123268 6662 63359039
Bradycardia neonatal 34.33 11.05 22 123299 930 63364771
Speech sound disorder 34.23 11.05 7 123314 3 63365698
Hyperglycinaemia 34.23 11.05 7 123314 3 63365698
Weight decreased 34.19 11.05 358 122963 276440 63089261
Growth retardation 34.15 11.05 25 123296 1316 63364385
Neoplasm progression 34.09 11.05 14 123307 36414 63329287
Antipsychotic drug level below therapeutic 33.93 11.05 15 123306 293 63365408
Brief psychotic disorder, with postpartum onset 33.85 11.05 9 123312 31 63365670
Drug withdrawal syndrome 33.81 11.05 123 123198 27071 63338630
Poor sucking reflex 33.74 11.05 15 123306 297 63365404
Pancreatitis 33.73 11.05 186 123135 48869 63316832
Congenital hair disorder 33.70 11.05 10 123311 56 63365645
Bone marrow oedema syndrome 33.63 11.05 9 123312 32 63365669
Skin ulcer 33.61 11.05 21 123300 43024 63322677
Drug level above therapeutic 33.57 11.05 44 123277 4761 63360940
Nipple disorder 33.49 11.05 11 123310 90 63365611
Withdrawal syndrome 33.42 11.05 100 123221 19897 63345804
Device expulsion 33.37 11.05 13 123308 34909 63330792
High arched palate 33.28 11.05 11 123310 92 63365609
Brain death 33.28 11.05 37 123284 3373 63362328
Ketosis-prone diabetes mellitus 33.21 11.05 8 123313 16 63365685
Fungal infection 33.19 11.05 15 123306 36859 63328842
CSF oligoclonal band present 33.18 11.05 16 123305 384 63365317
Screaming 32.88 11.05 36 123285 3226 63362475
Gaze palsy 32.87 11.05 25 123296 1395 63364306
Rabbit syndrome 32.85 11.05 15 123306 317 63365384
Joint range of motion decreased 32.80 11.05 11 123310 32417 63333284
Diverticulitis 32.73 11.05 18 123303 39539 63326162
Conjunctival hyperaemia 32.63 11.05 31 123290 2348 63363353
Congenital oral malformation 32.59 11.05 13 123308 194 63365507
Product use issue 32.47 11.05 273 123048 220247 63145454
Anticonvulsant drug level abnormal 32.41 11.05 9 123312 38 63365663
Dyscalculia 32.23 11.05 12 123309 147 63365554
Hypermobility syndrome 32.13 11.05 20 123301 803 63364898
Mutism 31.91 11.05 26 123295 1604 63364097
Mood altered 31.87 11.05 81 123240 14662 63351039
Gait disturbance 31.72 11.05 516 122805 182662 63183039
Angiomyolipoma 31.71 11.05 13 123308 209 63365492
Tic 31.36 11.05 25 123296 1495 63364206
Reading disorder 31.18 11.05 20 123301 847 63364854
Drooling 31.11 11.05 38 123283 3830 63361871
Renal tubular acidosis 31.06 11.05 26 123295 1666 63364035
Localised infection 30.99 11.05 10 123311 30200 63335501
Pancreatitis necrotising 30.80 11.05 26 123295 1686 63364015
Impaired reasoning 30.75 11.05 10 123311 79 63365622
Breast hyperplasia 30.57 11.05 14 123307 298 63365403
Pancreatitis acute 30.56 11.05 119 123202 27047 63338654
Ovarian granulosa-theca cell tumour 30.44 11.05 8 123313 26 63365675
Cerebral ventricle dilatation 30.39 11.05 21 123300 1008 63364693
Akinesia 30.33 11.05 25 123296 1568 63364133
Polydactyly 30.19 11.05 14 123307 307 63365394
Deafness congenital 30.13 11.05 7 123314 11 63365690
Feeling hot 30.07 11.05 32 123289 50322 63315379
Prognathism 30.01 11.05 10 123311 86 63365615
Strabismus congenital 29.80 11.05 9 123312 54 63365647
Cogwheel rigidity 29.58 11.05 27 123294 1943 63363758
Depression 29.51 11.05 541 122780 195951 63169750
Illness 29.50 11.05 31 123290 49028 63316673
Automatism 29.39 11.05 9 123312 57 63365644
Verbal abuse 29.32 11.05 10 123311 93 63365608
Congenital central nervous system anomaly 29.26 11.05 14 123307 330 63365371
Eye movement disorder 29.22 11.05 43 123278 5185 63360516
Pleocytosis 29.17 11.05 19 123302 826 63364875
Pneumonia 28.99 11.05 671 122650 456096 62909605
Mucosal inflammation 28.96 11.05 29 123292 46899 63318802
Stereotypy 28.77 11.05 15 123306 427 63365274
Palpitations 28.72 11.05 117 123204 112653 63253048
Accidental overdose 28.62 11.05 105 123216 23204 63342497
Thermal burn 28.55 11.05 46 123275 6000 63359701
Subileus 28.49 11.05 33 123288 3146 63362555
Hypophosphataemic osteomalacia 28.45 11.05 12 123309 208 63365493
Social avoidant behaviour 28.44 11.05 32 123289 2956 63362745
Disinhibition 28.41 11.05 19 123302 864 63364837
Polycystic ovaries 28.27 11.05 39 123282 4432 63361269
Shock 28.22 11.05 105 123216 23358 63342343
Epileptic encephalopathy 28.07 11.05 13 123308 284 63365417
Erythema 27.97 11.05 213 123108 175538 63190163
Echolalia 27.94 11.05 12 123309 218 63365483
Staring 27.78 11.05 24 123297 1606 63364095
Physical assault 27.65 11.05 19 123302 904 63364797
Hepatic cirrhosis 27.57 11.05 7 123314 24727 63340974
Cystitis 27.54 11.05 40 123281 54951 63310750
Metastases to bone 27.54 11.05 4 123317 21015 63344686
Eosinophilia 27.51 11.05 102 123219 22654 63343047
Sexually inappropriate behaviour 27.35 11.05 10 123311 116 63365585
Cerebellar syndrome 27.23 11.05 34 123287 3505 63362196
Ear disorder 27.18 11.05 36 123285 3935 63361766
Clonus 27.17 11.05 39 123282 4597 63361104
Conductive deafness 27.12 11.05 10 123311 119 63365582
Blood pressure fluctuation 27.03 11.05 30 123291 46287 63319414
Respiratory disorder neonatal 26.81 11.05 21 123300 1224 63364477
Diplopia 26.74 11.05 104 123217 23624 63342077
Negativism 26.71 11.05 14 123307 403 63365298
Upper respiratory tract infection 26.39 11.05 77 123244 81970 63283731
Ulcer 26.16 11.05 9 123312 26098 63339603
Nasal disorder 26.12 11.05 30 123291 2834 63362867
Lactate pyruvate ratio increased 26.08 11.05 9 123312 87 63365614
Heart rate decreased 26.06 11.05 30 123291 45530 63320171
Ultrasound ovary abnormal 25.99 11.05 9 123312 88 63365613
Chorea 25.85 11.05 23 123298 1601 63364100
Myocardial infarction 25.84 11.05 103 123218 99790 63265911
Basal cell carcinoma 25.80 11.05 11 123310 27980 63337721
Drug monitoring procedure incorrectly performed 25.75 11.05 11 123310 197 63365504
Heterophoria 25.51 11.05 7 123314 28 63365673
Foetal death 25.50 11.05 62 123259 10918 63354783
Apraxia 25.49 11.05 24 123297 1797 63363904
Drug ineffective 25.42 11.05 2356 120965 1042409 62323292
Motor dysfunction 25.24 11.05 61 123260 10700 63355001
Sciatica 25.11 11.05 18 123303 34306 63331395
Hypothyroidism 25.00 11.05 155 123166 42477 63323224
Illogical thinking 24.96 11.05 8 123313 60 63365641
Cardiac failure 24.95 11.05 89 123232 89053 63276648
Hereditary ataxia 24.94 11.05 7 123314 31 63365670
Intentional product misuse 24.93 11.05 203 123118 60714 63304987
Sinus congestion 24.82 11.05 3 123318 18120 63347581
Precocious puberty 24.78 11.05 11 123310 217 63365484
Palmar-plantar erythrodysaesthesia syndrome 24.73 11.05 7 123314 23008 63342693
Poisoning deliberate 24.63 11.05 62 123259 11156 63354545
Dacryostenosis congenital 24.58 11.05 6 123315 13 63365688
Self-injurious ideation 24.50 11.05 28 123293 2631 63363070
Vestibular migraine 24.46 11.05 11 123310 224 63365477
Troponin increased 24.42 11.05 58 123263 10063 63355638
Obesity 24.35 11.05 119 123202 29833 63335868
Blood cholesterol increased 24.29 11.05 97 123224 93935 63271766
Agranulocytosis 24.24 11.05 105 123216 25029 63340672
Congenital cystic kidney disease 24.13 11.05 13 123308 396 63365305
Increased appetite 24.12 11.05 56 123265 9574 63356127
Drug eruption 24.05 11.05 115 123206 28579 63337122
Full blood count abnormal 24.04 11.05 16 123305 31701 63334000
Mitochondrial cytopathy 23.94 11.05 11 123310 236 63365465
Injection site rash 23.69 11.05 4 123317 18805 63346896
Choreoathetosis 23.60 11.05 14 123307 515 63365186
Surgery 23.56 11.05 21 123300 35891 63329810
Hypervolaemia 23.40 11.05 13 123308 28400 63337301
Dysgeusia 23.37 11.05 34 123287 46676 63319025
Lymphangioleiomyomatosis 23.26 11.05 10 123311 182 63365519
Rotavirus infection 23.26 11.05 12 123309 334 63365367
Congenital flat feet 23.18 11.05 7 123314 42 63365659
Sarcoidosis 23.11 11.05 46 123275 7076 63358625
Executive dysfunction 23.02 11.05 10 123311 187 63365514
Influenza B virus test positive 22.89 11.05 11 123310 262 63365439
Generalised anxiety disorder 22.86 11.05 24 123297 2050 63363651
Pulmonary hypertension 22.84 11.05 23 123298 37100 63328601
Borderline personality disorder 22.67 11.05 16 123305 795 63364906
Pneumonitis 22.62 11.05 21 123300 35201 63330500
Hypotonia neonatal 22.57 11.05 19 123302 1227 63364474
Osteonecrosis of jaw 22.49 11.05 21 123300 35102 63330599
Therapy interrupted 22.49 11.05 18 123303 32437 63333264
Hyporesponsive to stimuli 22.44 11.05 18 123303 1086 63364615
Procedural pain 22.38 11.05 7 123314 21562 63344139
Metabolic syndrome 22.37 11.05 21 123300 1567 63364134
Conversion disorder 22.34 11.05 22 123299 1742 63363959
Right ventricular hypertrophy 22.31 11.05 15 123306 688 63365013
Hypersomnia-bulimia syndrome 22.30 11.05 5 123316 6 63365695
Macroglossia 22.28 11.05 15 123306 690 63365011
Metastases to liver 22.26 11.05 9 123312 23630 63342071
Wound infection 22.12 11.05 7 123314 21403 63344298
Miosis 22.09 11.05 46 123275 7307 63358394
Cross sensitivity reaction 22.04 11.05 24 123297 2138 63363563
Illiteracy 21.87 11.05 6 123315 24 63365677
Aspiration 21.79 11.05 58 123263 10793 63354908
Grip strength decreased 21.79 11.05 8 123313 22279 63343422
Urine amphetamine positive 21.79 11.05 7 123314 53 63365648
Therapeutic product effective for unapproved indication 21.79 11.05 8 123313 94 63365607
Sputum discoloured 21.68 11.05 3 123318 16344 63349357
Prominent epicanthal folds 21.67 11.05 7 123314 54 63365647
Creatinine renal clearance decreased 21.61 11.05 3 123318 16305 63349396
Autonomic nervous system imbalance 21.56 11.05 27 123294 2791 63362910
Thinking abnormal 21.49 11.05 57 123264 10586 63355115
Developmental regression 21.48 11.05 6 123315 26 63365675
Cleft uvula 21.47 11.05 5 123316 8 63365693
Rectal haemorrhage 21.43 11.05 39 123282 48991 63316710
Porphyria acute 21.43 11.05 18 123303 1159 63364542
Drug screen false positive 21.43 11.05 16 123305 868 63364833
Neoplasm malignant 21.40 11.05 16 123305 29845 63335856
Retinitis pigmentosa 21.34 11.05 8 123313 100 63365601
Neglect of personal appearance 21.13 11.05 8 123313 103 63365598
Bradypnoea 21.01 11.05 30 123291 3520 63362181
Intelligence test abnormal 20.98 11.05 4 123317 0 63365701
Anomaly of orbit, congenital 20.98 11.05 4 123317 0 63365701
Optic nerve hypoplasia 20.98 11.05 4 123317 0 63365701
Gaucher's disease 20.98 11.05 4 123317 0 63365701
Hypotension 20.98 11.05 685 122636 271919 63093782
Right ventricular failure 20.90 11.05 4 123317 17184 63348517
Hypoventilation 20.87 11.05 35 123286 4719 63360982
Mitochondrial enzyme deficiency 20.78 11.05 6 123315 30 63365671
Hiatus hernia 20.69 11.05 8 123313 21586 63344115
Dysphagia 20.68 11.05 263 123058 88322 63277379
Megakaryocytes abnormal 20.62 11.05 6 123315 31 63365670
Pulmonary arterial hypertension 20.61 11.05 9 123312 22568 63343133
Osteoporosis 20.55 11.05 51 123270 57287 63308414
Ligament laxity 20.49 11.05 9 123312 173 63365528
Epileptic aura 20.44 11.05 7 123314 66 63365635
Reduced facial expression 20.35 11.05 22 123299 1944 63363757
Monocytosis 20.30 11.05 13 123308 549 63365152
Immunodeficiency 20.26 11.05 7 123314 20247 63345454
Dyspepsia 20.22 11.05 116 123205 102080 63263621
Acquired macroglossia 20.21 11.05 9 123312 179 63365522
Injection site haemorrhage 20.21 11.05 11 123310 24303 63341398
Tooth infection 20.11 11.05 5 123316 17915 63347786
Thyroxine free decreased 20.04 11.05 14 123307 684 63365017
Judgement impaired 20.04 11.05 15 123306 817 63364884
Kidney infection 19.98 11.05 10 123311 23166 63342535
Oral herpes 19.97 11.05 13 123308 26061 63339640
Food interaction 19.94 11.05 15 123306 823 63364878
Heart disease congenital 19.89 11.05 18 123303 1281 63364420
Perseveration 19.83 11.05 10 123311 265 63365436
Attention-seeking behaviour 19.81 11.05 7 123314 73 63365628
Lennox-Gastaut syndrome 19.76 11.05 10 123311 267 63365434
Dysphoria 19.76 11.05 35 123286 4931 63360770
Hypoplastic left heart syndrome 19.72 11.05 9 123312 190 63365511
Memory impairment 19.67 11.05 298 123023 103960 63261741
Urinary tract infection 19.63 11.05 379 122942 264305 63101396
Lung disorder 19.61 11.05 59 123262 62202 63303499
Transient aphasia 19.59 11.05 6 123315 38 63365663
Nasal polyps 19.59 11.05 39 123282 6000 63359701
Cardiac steatosis 19.46 11.05 6 123315 39 63365662
Hypersomnia 19.43 11.05 78 123243 17977 63347724
Hydrocephalus 19.37 11.05 36 123285 5264 63360437
Knee deformity 19.35 11.05 18 123303 1327 63364374
Congenital hepatomegaly 19.33 11.05 5 123316 15 63365686
Micrognathia 19.26 11.05 10 123311 282 63365419
Fanconi syndrome acquired 19.19 11.05 16 123305 1020 63364681
Pulmonary mass 19.10 11.05 10 123311 22586 63343115
Lipids 19.09 11.05 5 123316 16 63365685
Congenital hearing disorder 19.09 11.05 5 123316 16 63365685
Systemic inflammatory response syndrome 19.08 11.05 37 123284 5584 63360117
Erythema multiforme 19.07 11.05 53 123268 10116 63355585
Blood insulin increased 19.05 11.05 8 123313 137 63365564
Tachyphrenia 19.03 11.05 18 123303 1356 63364345
Acute generalised exanthematous pustulosis 19.02 11.05 56 123265 11043 63354658
Breast cancer 18.98 11.05 41 123280 48342 63317359
Mixed anxiety and depressive disorder 18.95 11.05 10 123311 292 63365409
Inappropriate affect 18.79 11.05 15 123306 899 63364802
Social (pragmatic) communication disorder 18.75 11.05 4 123317 3 63365698
School refusal 18.75 11.05 4 123317 3 63365698
Microstomia 18.75 11.05 4 123317 3 63365698
Sneezing 18.74 11.05 6 123315 18212 63347489
Joint effusion 18.68 11.05 5 123316 17055 63348646
Nephrocalcinosis 18.63 11.05 16 123305 1062 63364639
Flatulence 18.63 11.05 24 123297 34678 63331023
Hyperphagia 18.57 11.05 20 123301 1759 63363942
Cellulitis 18.46 11.05 89 123232 81869 63283832
Pneumocystis jirovecii pneumonia 18.44 11.05 5 123316 16909 63348792
Musculoskeletal discomfort 18.34 11.05 6 123315 17961 63347740
Constipation 18.27 11.05 317 123004 224626 63141075
Microphthalmos 18.20 11.05 8 123313 154 63365547
Exostosis 18.17 11.05 6 123315 17856 63347845
Ascites 18.16 11.05 32 123289 40696 63325005
Rash morbilliform 18.08 11.05 27 123294 3298 63362403
Bladder sphincter atony 18.06 11.05 8 123313 157 63365544
Poor personal hygiene 18.06 11.05 10 123311 322 63365379
Sinus tachycardia 18.03 11.05 94 123227 24174 63341527
Device issue 18.02 11.05 12 123309 23769 63341932
Peripheral venous disease 18.00 11.05 4 123317 15473 63350228
Urine sodium increased 17.96 11.05 7 123314 98 63365603
Hypoproteinaemia 17.91 11.05 21 123300 2028 63363673
Ventricular arrhythmia 17.91 11.05 29 123292 3799 63361902
Emotional disorder 17.90 11.05 62 123259 13317 63352384
Transaminases increased 17.74 11.05 113 123208 31254 63334447
Blood triglycerides increased 17.70 11.05 59 123262 12429 63353272
Lip erosion 17.70 11.05 15 123306 978 63364723
Hyperreflexia 17.68 11.05 37 123284 5897 63359804
Acidosis 17.67 11.05 55 123266 11178 63354523
Tendonitis 17.62 11.05 8 123313 19607 63346094
Drug dependence 17.62 11.05 94 123227 24389 63341312
Otitis media 17.59 11.05 33 123288 4858 63360843
Eye pain 17.58 11.05 24 123297 33830 63331871
Benign congenital hypotonia 17.57 11.05 6 123315 56 63365645
Transfusion 17.56 11.05 4 123317 15213 63350488
Brachydactyly 17.52 11.05 7 123314 105 63365596
Plasmodium falciparum infection 17.49 11.05 5 123316 24 63365677
Colitis ulcerative 17.42 11.05 15 123306 26076 63339625
Opisthotonus 17.41 11.05 10 123311 346 63365355
Lipid metabolism disorder 17.39 11.05 6 123315 58 63365643
Encephalitis 17.37 11.05 47 123274 8833 63356868
Full blood count decreased 17.33 11.05 15 123306 26009 63339692
Spina bifida occulta 17.33 11.05 4 123317 6 63365695
Head titubation 17.32 11.05 14 123307 854 63364847
Hip fracture 17.30 11.05 19 123302 29455 63336246
VIth nerve paralysis 17.29 11.05 14 123307 856 63364845
Pressure of speech 17.29 11.05 13 123308 713 63364988
Flight of ideas 17.21 11.05 11 123310 463 63365238
Electrocardiogram T wave inversion 17.15 11.05 27 123294 3454 63362247
Hospitalisation 17.14 11.05 96 123225 84985 63280716
Monocyte count decreased 17.07 11.05 21 123300 2132 63363569
Paraesthesia oral 17.07 11.05 8 123313 19248 63346453
Postictal state 17.06 11.05 15 123306 1028 63364673
Urine calcium/creatinine ratio increased 17.05 11.05 7 123314 113 63365588
Acute myeloid leukaemia 17.03 11.05 6 123315 17141 63348560
Oral pain 17.00 11.05 18 123303 28376 63337325
Anotia 16.95 11.05 4 123317 7 63365694
Teratogenicity 16.89 11.05 9 123312 268 63365433
Renal hypoplasia 16.85 11.05 5 123316 28 63365673
Clostridium difficile infection 16.79 11.05 20 123301 29902 63335799
Blood urea decreased 16.79 11.05 22 123299 2380 63363321
Cardio-respiratory arrest 16.64 11.05 184 123137 59775 63305926
Oral candidiasis 16.62 11.05 12 123309 22786 63342915
Sinus bradycardia 16.58 11.05 64 123257 14487 63351214
Dysphonia 16.56 11.05 43 123278 47571 63318130
Sinus disorder 16.54 11.05 14 123307 24539 63341162
Limb discomfort 16.53 11.05 20 123301 29696 63336005
Incontinence 16.53 11.05 55 123266 11577 63354124
Lipids abnormal 16.42 11.05 9 123312 284 63365417
Saccadic eye movement 16.38 11.05 6 123315 70 63365631
Joint laxity 16.35 11.05 22 123299 2442 63363259
Aspartate aminotransferase decreased 16.34 11.05 13 123308 775 63364926
Rib fracture 16.34 11.05 12 123309 22585 63343116
Haemoptysis 16.33 11.05 19 123302 28707 63336994
Parkinsonian gait 16.30 11.05 11 123310 508 63365193
Head circumference abnormal 16.29 11.05 4 123317 9 63365692
Electrocardiogram J wave abnormal 16.29 11.05 4 123317 9 63365692
False positive investigation result 16.24 11.05 12 123309 641 63365060
Movement disorder 16.16 11.05 84 123237 21577 63344124
Drug-disease interaction 16.13 11.05 11 123310 517 63365184
Intestinal ischaemia 16.11 11.05 41 123280 7427 63358274
Arrhythmia 16.09 11.05 128 123193 38012 63327689
Glassy eyes 15.93 11.05 6 123315 76 63365625
Schizoaffective disorder bipolar type 15.91 11.05 7 123314 135 63365566
Pancreatic injury 15.90 11.05 5 123316 35 63365666
Rash pruritic 15.88 11.05 61 123260 59738 63305963
Premature baby 15.88 11.05 81 123240 20654 63345047
Candida infection 15.86 11.05 19 123302 28332 63337369
Hepatomegaly 15.83 11.05 55 123266 11834 63353867
Anuria 15.80 11.05 57 123264 12494 63353207
Drug level changed 15.76 11.05 8 123313 215 63365486
Tibial torsion 15.74 11.05 3 123318 0 63365701
Rhinotracheitis 15.74 11.05 3 123318 0 63365701
Congenital cutis laxa 15.74 11.05 3 123318 0 63365701
Diabetic encephalopathy 15.74 11.05 3 123318 0 63365701
Carnitine palmitoyltransferase deficiency 15.74 11.05 3 123318 0 63365701
Alpers disease 15.74 11.05 3 123318 0 63365701
Cognitive linguistic deficit 15.74 11.05 3 123318 0 63365701
Congenital myopia 15.74 11.05 3 123318 0 63365701
Blood 1,25-dihydroxycholecalciferol decreased 15.74 11.05 3 123318 0 63365701
Cryptorchism 15.74 11.05 3 123318 0 63365701
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 15.74 11.05 3 123318 0 63365701
Bacteraemia 15.70 11.05 7 123314 17341 63348360
Scoliosis 15.68 11.05 42 123279 7846 63357855
Epileptic psychosis 15.66 11.05 5 123316 37 63365664
Developmental coordination disorder 15.66 11.05 5 123316 37 63365664
Product use in unapproved indication 15.62 11.05 457 122864 178623 63187078
Incoherent 15.60 11.05 30 123291 4500 63361201
Anxiety 15.54 11.05 542 122779 216999 63148702
Asphyxia 15.54 11.05 36 123285 6145 63359556
Serositis 15.51 11.05 12 123309 687 63365014
Mental disability 15.46 11.05 6 123315 83 63365618
Vascular encephalopathy 15.43 11.05 10 123311 431 63365270
Nodule 15.42 11.05 11 123310 21015 63344686
Withdrawal catatonia 15.39 11.05 6 123315 84 63365617
Grunting 15.37 11.05 8 123313 227 63365474
Liver function test increased 15.34 11.05 25 123296 32786 63332915
Fine motor delay 15.33 11.05 7 123314 148 63365553
Simple partial seizures 15.31 11.05 11 123310 562 63365139
Cerebrovascular accident 15.31 11.05 135 123186 107889 63257812
Multiple allergies 15.20 11.05 4 123317 13798 63351903
Clonic convulsion 15.12 11.05 12 123309 713 63364988
Prothrombin time shortened 15.08 11.05 19 123302 1976 63363725
Glaucoma 15.07 11.05 9 123312 18896 63346805
Intestinal strangulation 15.01 11.05 6 123315 90 63365611
Congenital eye disorder 14.99 11.05 4 123317 14 63365687
Drug level fluctuating 14.93 11.05 10 123311 456 63365245
Diabetes mellitus 14.91 11.05 170 123151 55640 63310061
Electrocardiogram QRS complex shortened 14.87 11.05 10 123311 459 63365242
Congenital nipple anomaly 14.78 11.05 4 123317 15 63365686
Laryngeal stenosis 14.70 11.05 14 123307 1064 63364637
Nose deformity 14.67 11.05 7 123314 164 63365537
Faecal vomiting 14.51 11.05 11 123310 611 63365090
Maternal exposure during breast feeding 14.50 11.05 28 123293 4213 63361488
Transferrin saturation decreased 14.46 11.05 12 123309 760 63364941
Accidental poisoning 14.41 11.05 11 123310 617 63365084
Rebound effect 14.41 11.05 29 123292 4497 63361204
Crying 14.40 11.05 86 123235 23257 63342444
Amniocentesis abnormal 14.39 11.05 6 123315 101 63365600
Bipolar II disorder 14.31 11.05 9 123312 368 63365333
Tubo-ovarian abscess 14.31 11.05 9 123312 368 63365333
Pyroglutamic acidosis 14.30 11.05 11 123310 624 63365077
Pulmonary valve stenosis congenital 14.25 11.05 7 123314 175 63365526
Ebstein's anomaly 14.20 11.05 4 123317 18 63365683
Extensor plantar response 14.15 11.05 15 123306 1296 63364405
Diverticulum 14.15 11.05 3 123318 11988 63353713
Regressive behaviour 14.07 11.05 7 123314 180 63365521
Seasonal allergy 14.04 11.05 12 123309 20938 63344763
Cardiac disorder 14.04 11.05 51 123270 50765 63314936
Mucosal erosion 14.03 11.05 16 123305 1500 63364201
Injury 14.03 11.05 84 123237 73163 63292538
Vomiting 13.99 11.05 918 122403 558699 62807002
Adenoidal hypertrophy 13.99 11.05 5 123316 54 63365647
Hypoglycaemia neonatal 13.94 11.05 13 123308 962 63364739
Coronary artery disease 13.93 11.05 26 123295 32351 63333350
Blood bicarbonate increased 13.92 11.05 12 123309 801 63364900
Childhood asthma 13.83 11.05 5 123316 56 63365645
Device related infection 13.82 11.05 15 123306 23377 63342324
Idiosyncratic drug reaction 13.73 11.05 12 123309 816 63364885
Coma acidotic 13.72 11.05 6 123315 114 63365587
Gamma-glutamyltransferase increased 13.70 11.05 113 123208 33918 63331783
Maternal drugs affecting foetus 13.70 11.05 31 123290 5211 63360490
Rebound psychosis 13.70 11.05 7 123314 191 63365510
Pharyngeal disorder 13.68 11.05 18 123303 1955 63363746
Blood pyruvic acid increased 13.66 11.05 3 123318 3 63365698
Niemann-Pick disease 13.66 11.05 3 123318 3 63365698
Tympanic membrane disorder 13.66 11.05 7 123314 192 63365509
Social problem 13.60 11.05 12 123309 826 63364875
Blood citric acid increased 13.60 11.05 5 123316 59 63365642
Cardiac arrest 13.59 11.05 254 123067 92291 63273410
Respiratory tract congestion 13.51 11.05 9 123312 17823 63347878
Hepatic steatosis 13.51 11.05 99 123222 28670 63337031
Infusion site pain 13.49 11.05 8 123313 16861 63348840
Acute kidney injury 13.48 11.05 399 122922 263016 63102685
Respiratory arrest 13.47 11.05 109 123212 32536 63333165
Coma hepatic 13.45 11.05 11 123310 682 63365019
Oedema 13.40 11.05 123 123198 97499 63268202
Herpes oesophagitis 13.37 11.05 7 123314 201 63365500
Gliosis 13.37 11.05 8 123313 299 63365402
Skin disorder 13.32 11.05 23 123298 29484 63336217
Skin cancer 13.31 11.05 3 123318 11492 63354209
Dry eye 13.29 11.05 38 123283 40723 63324978
Quadriparesis 13.28 11.05 18 123303 2011 63363690
Activated partial thromboplastin time abnormal 13.26 11.05 6 123315 124 63365577
Consciousness fluctuating 13.25 11.05 12 123309 855 63364846
Juvenile myoclonic epilepsy 13.25 11.05 4 123317 24 63365677
Intervertebral disc degeneration 13.24 11.05 7 123314 15725 63349976
Dehydration 13.22 11.05 247 123074 173107 63192594
Cortical visual impairment 13.20 11.05 3 123318 4 63365697
Benign rolandic epilepsy 13.20 11.05 3 123318 4 63365697
Blood sodium increased 13.19 11.05 21 123300 2711 63362990
Therapeutic response changed 13.17 11.05 13 123308 1032 63364669
Uveitis 13.15 11.05 4 123317 12549 63353152
Intervertebral disc protrusion 13.14 11.05 16 123305 23693 63342008
Cortical dysplasia 13.11 11.05 4 123317 25 63365676
Gestational diabetes 13.11 11.05 41 123280 8355 63357346
Malignant melanoma 13.07 11.05 3 123318 11353 63354348
Bone density decreased 13.06 11.05 6 123315 14606 63351095
Circulatory collapse 13.01 11.05 80 123241 21858 63343843
Febrile convulsion 12.97 11.05 9 123312 435 63365266
Congenital laryngeal stridor 12.96 11.05 5 123316 68 63365633
Decreased activity 12.91 11.05 34 123287 6286 63359415
Aura 12.88 11.05 13 123308 1060 63364641
Hostility 12.86 11.05 17 123304 1855 63363846
Therapeutic product ineffective for unapproved indication 12.82 11.05 7 123314 219 63365482
Gastric disorder 12.81 11.05 34 123287 37335 63328366
High-pitched crying 12.72 11.05 4 123317 28 63365673
Hyperacusis 12.72 11.05 18 123303 2095 63363606
Severe myoclonic epilepsy of infancy 12.70 11.05 5 123316 72 63365629
Carpal tunnel syndrome 12.69 11.05 13 123308 20804 63344897
Adverse event 12.66 11.05 78 123243 67481 63298220
Congenital hypothyroidism 12.65 11.05 7 123314 225 63365476
Renal failure 12.61 11.05 157 123164 117495 63248206
Status migrainosus 12.60 11.05 6 123315 140 63365561
Suspected suicide attempt 12.60 11.05 6 123315 140 63365561
Neutrophilia 12.58 11.05 27 123294 4379 63361322
Gout 12.58 11.05 5 123316 13266 63352435
Device dislocation 12.58 11.05 19 123302 25686 63340015
Cell death 12.57 11.05 20 123301 2581 63363120
Sleep disorder due to a general medical condition 12.56 11.05 4 123317 12184 63353517
Megacolon 12.55 11.05 17 123304 1898 63363803
Congenital inguinal hernia 12.45 11.05 3 123318 6 63365695
Enlarged foetal cisterna magna 12.45 11.05 3 123318 6 63365695
Congenital neurological disorder 12.45 11.05 3 123318 6 63365695
Injection site warmth 12.44 11.05 7 123314 15188 63350513
Encapsulating peritoneal sclerosis 12.40 11.05 8 123313 342 63365359
Upper gastrointestinal haemorrhage 12.39 11.05 11 123310 18841 63346860
Gallbladder disorder 12.38 11.05 11 123310 18831 63346870
Hand-eye coordination impaired 12.37 11.05 4 123317 31 63365670
Convulsive threshold lowered 12.36 11.05 8 123313 344 63365357
Blood phosphorus increased 12.30 11.05 22 123299 3123 63362578
Central nervous system lesion 12.30 11.05 47 123274 10588 63355113
Hyperaldosteronism 12.27 11.05 7 123314 239 63365462
Histiocytic necrotising lymphadenitis 12.26 11.05 4 123317 32 63365669
Injection site urticaria 12.24 11.05 6 123315 14067 63351634
Reproductive tract disorder 12.22 11.05 6 123315 150 63365551
Haemorrhage 12.21 11.05 69 123252 60953 63304748
Homicidal ideation 12.17 11.05 16 123305 1736 63363965
Tachypnoea 12.16 11.05 66 123255 17236 63348465
Syringomyelia 12.15 11.05 6 123315 152 63365549
Cerebral palsy 12.15 11.05 6 123315 152 63365549
Deja vu 12.11 11.05 5 123316 82 63365619
Rhinitis allergic 12.09 11.05 50 123271 11677 63354024
Cerebral disorder 12.09 11.05 27 123294 4499 63361202
Dry mouth 12.08 11.05 95 123226 77768 63287933
Neurotoxicity 12.07 11.05 65 123256 16925 63348776
Joint hyperextension 12.06 11.05 8 123313 359 63365342
Copper deficiency 12.05 11.05 5 123316 83 63365618
Aphthous ulcer 12.03 11.05 6 123315 13932 63351769
Adverse drug reaction 12.02 11.05 98 123223 79616 63286085
Blood bilirubin decreased 12.02 11.05 11 123310 794 63364907
Alkalosis 11.98 11.05 8 123313 363 63365338
Colitis 11.94 11.05 51 123270 48477 63317224
Tooth development disorder 11.94 11.05 4 123317 35 63365666
Thought blocking 11.93 11.05 6 123315 158 63365543
Musculoskeletal chest pain 11.93 11.05 14 123307 21069 63344632
Faeces discoloured 11.93 11.05 11 123310 18498 63347203
Food refusal 11.90 11.05 8 123313 367 63365334
Developmental hip dysplasia 11.89 11.05 14 123307 1358 63364343
Blood pressure diastolic decreased 11.88 11.05 16 123305 22690 63343011
Electrocardiogram J wave 11.86 11.05 3 123318 8 63365693
Binocular eye movement disorder 11.84 11.05 4 123317 36 63365665
Device difficult to use 11.84 11.05 5 123316 12791 63352910
Perforation 11.83 11.05 13 123308 1170 63364531
Electrocardiogram abnormal 11.82 11.05 42 123279 9137 63356564
Viral infection 11.81 11.05 33 123288 35630 63330071
Disease recurrence 11.79 11.05 94 123227 27936 63337765
Metastases to lung 11.77 11.05 5 123316 12745 63352956
Bronchiolitis 11.76 11.05 20 123301 2727 63362974
Congenital tracheomalacia 11.75 11.05 4 123317 37 63365664
Blood testosterone increased 11.73 11.05 6 123315 164 63365537
Polyhydramnios 11.72 11.05 18 123303 2253 63363448
Ageusia 11.72 11.05 6 123315 13722 63351979
Product administered to patient of inappropriate age 11.69 11.05 22 123299 3246 63362455
Blood test abnormal 11.69 11.05 8 123313 15621 63350080
Toothache 11.69 11.05 12 123309 19187 63346514
Persistent left superior vena cava 11.65 11.05 4 123317 38 63365663
Amblyopia 11.64 11.05 7 123314 264 63365437
Anomaly of external ear congenital 11.63 11.05 6 123315 167 63365534
Congenital gastric anomaly 11.60 11.05 3 123318 9 63365692
Hemianopia homonymous 11.59 11.05 10 123311 668 63365033
White blood cell count decreased 11.59 11.05 353 122968 138751 63226950
Ear pain 11.53 11.05 34 123287 36084 63329617
Heart rate irregular 11.53 11.05 16 123305 22405 63343296
Blood alkaline phosphatase increased 11.53 11.05 131 123190 42836 63322865
Amino acid level increased 11.50 11.05 8 123313 388 63365313
Haematocrit decreased 11.50 11.05 122 123199 39218 63326483
Hernia 11.50 11.05 5 123316 12569 63353132
Hyperleukocytosis 11.49 11.05 10 123311 676 63365025
Delusional disorder, unspecified type 11.49 11.05 8 123313 389 63365312
Slow response to stimuli 11.48 11.05 12 123309 1020 63364681
Intention tremor 11.47 11.05 8 123313 390 63365311
Decreased appetite 11.46 11.05 386 122935 250666 63115035
Palatal disorder 11.45 11.05 7 123314 272 63365429
Impaired gastric emptying 11.37 11.05 3 123318 10329 63355372
Autoimmune disorder 11.32 11.05 10 123311 17167 63348534
Oppositional defiant disorder 11.30 11.05 4 123317 42 63365659
Liver injury 11.28 11.05 70 123251 60450 63305251
Congenital nail disorder 11.25 11.05 5 123316 99 63365602
Muscle twitching 11.21 11.05 71 123250 19597 63346104
Nikolsky's sign 11.20 11.05 5 123316 100 63365601
Postictal paralysis 11.20 11.05 5 123316 100 63365601
Haemorrhoids 11.20 11.05 16 123305 22134 63343567
Hyporeflexia 11.19 11.05 16 123305 1879 63363822
Congenital oesophageal anomaly 11.14 11.05 3 123318 11 63365690
Gastroenteritis viral 11.14 11.05 18 123303 23682 63342019
Sudden death 11.13 11.05 45 123276 10404 63355297
Disorganised speech 11.12 11.05 13 123308 1252 63364449
Delusion of reference 11.07 11.05 5 123316 103 63365598
Product administration error 11.05 11.05 78 123243 22319 63343382

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1642.27 11.50 2028 133942 102829 34718132
Hyperammonaemia 1265.51 11.50 577 135393 5790 34815171
Drug interaction 1177.63 11.50 2661 133309 223285 34597676
Foetal anticonvulsant syndrome 965.51 11.50 302 135668 885 34820076
Dysmorphism 964.71 11.50 388 135582 2768 34818193
Aggression 927.45 11.50 939 135031 38025 34782936
Hyperammonaemic encephalopathy 802.29 11.50 312 135658 2012 34818949
Neuroleptic malignant syndrome 740.47 11.50 590 135380 17344 34803617
Foetal exposure during pregnancy 695.23 11.50 798 135172 37303 34783658
Status epilepticus 662.18 11.50 479 135491 12135 34808826
Autism spectrum disorder 598.81 11.50 252 135718 2044 34818917
Somnolence 569.91 11.50 1303 134667 109813 34711148
Epilepsy 547.97 11.50 538 135432 20957 34800004
Speech disorder developmental 493.31 11.50 217 135753 1983 34818978
Psychotic disorder 484.89 11.50 535 135435 23917 34797044
Generalised tonic-clonic seizure 477.55 11.50 496 135474 20678 34800283
Developmental delay 475.40 11.50 227 135743 2548 34818413
Dyspnoea 462.43 11.50 472 135498 376310 34444651
Sopor 460.17 11.50 380 135590 11756 34809205
Mania 433.85 11.50 332 135638 9179 34811782
Psychomotor retardation 433.31 11.50 233 135737 3417 34817544
Learning disorder 421.47 11.50 159 135811 932 34820029
Abnormal behaviour 420.33 11.50 502 135468 24467 34796494
Psychomotor skills impaired 415.78 11.50 232 135738 3674 34817287
Depression 415.38 11.50 1062 134908 96036 34724925
Diarrhoea 406.11 11.50 556 135414 389356 34431605
Ammonia increased 399.45 11.50 235 135735 4134 34816827
Agitation 394.08 11.50 759 135211 56640 34764321
Extrapyramidal disorder 382.76 11.50 351 135619 12529 34808432
Intellectual disability 376.35 11.50 155 135815 1183 34819778
Sedation 369.57 11.50 432 135538 20574 34800387
Multiple-drug resistance 360.16 11.50 235 135735 5004 34815957
Parkinsonism 355.73 11.50 277 135693 7861 34813100
Behaviour disorder 349.22 11.50 225 135745 4685 34816276
Language disorder 345.70 11.50 171 135799 2085 34818876
Cognitive disorder 336.73 11.50 483 135487 28210 34792751
Febrile neutropenia 321.07 11.50 70 135900 136779 34684182
Arthralgia 317.71 11.50 132 135838 169909 34651052
Granulocytopenia 314.44 11.50 236 135734 6331 34814630
Death 296.87 11.50 698 135272 397351 34423610
Petit mal epilepsy 279.91 11.50 165 135805 2913 34818048
Acute kidney injury 272.02 11.50 482 135488 304506 34516455
Psychomotor hyperactivity 271.92 11.50 255 135715 9367 34811594
Disturbance in attention 268.85 11.50 412 135558 25533 34795428
Irritability 268.51 11.50 401 135569 24289 34796672
Coma 268.03 11.50 566 135404 45112 34775849
Toxicity to various agents 266.07 11.50 1504 134466 198858 34622103
Antipsychotic drug level increased 264.77 11.50 173 135797 3692 34817269
Schizophrenia 259.09 11.50 237 135733 8429 34812532
Salivary hypersecretion 255.71 11.50 235 135735 8409 34812552
Nausea 254.82 11.50 594 135376 339314 34481647
Fatigue 252.09 11.50 681 135289 369972 34450989
Akathisia 248.76 11.50 225 135745 7884 34813077
Attention deficit hyperactivity disorder 248.10 11.50 143 135827 2416 34818545
Ataxia 242.13 11.50 284 135686 13569 34807392
Dysgraphia 238.40 11.50 134 135836 2153 34818808
Congenital nose malformation 236.13 11.50 68 135902 134 34820827
Hypospadias 233.36 11.50 149 135821 3052 34817909
Anaemia 232.01 11.50 343 135627 232992 34587969
Drug level increased 226.27 11.50 349 135621 21747 34799214
Paranoia 220.28 11.50 253 135717 11815 34809146
Suicide attempt 217.16 11.50 474 135496 38642 34782319
Intentional overdose 212.22 11.50 502 135468 43172 34777789
Atrial fibrillation 205.40 11.50 110 135860 122283 34698678
Tremor 199.40 11.50 740 135230 81847 34739114
Intentional self-injury 196.61 11.50 255 135715 13516 34807445
Tardive dyskinesia 196.23 11.50 170 135800 5620 34815341
Speech disorder 193.97 11.50 354 135616 25332 34795629
Antipsychotic drug level below therapeutic 191.76 11.50 121 135849 2426 34818535
Enuresis 190.33 11.50 117 135853 2236 34818725
Myocardial infarction 190.11 11.50 118 135852 120967 34699994
Pain 189.91 11.50 315 135655 204360 34616601
Hypertelorism 189.82 11.50 75 135895 507 34820454
Depressed level of consciousness 186.41 11.50 472 135498 42369 34778592
Cardiac failure congestive 184.53 11.50 48 135922 83222 34737739
Mental impairment 184.36 11.50 214 135756 10108 34810853
Delusion 183.57 11.50 236 135734 12399 34808562
Pneumonia 183.34 11.50 758 135212 361869 34459092
Pain in extremity 180.38 11.50 137 135833 126376 34694585
Overdose 178.13 11.50 764 135206 90295 34730666
Anticonvulsant drug level increased 177.49 11.50 98 135872 1518 34819443
Neuropathy peripheral 177.02 11.50 52 135918 83211 34737750
Drug level decreased 175.39 11.50 183 135787 7663 34813298
Hypotonia 173.46 11.50 182 135788 7671 34813290
Electroencephalogram abnormal 172.38 11.50 112 135858 2366 34818595
Disease progression 170.09 11.50 105 135865 107972 34712989
Partial seizures 169.95 11.50 144 135826 4616 34816345
Malignant neoplasm progression 169.74 11.50 65 135905 87981 34732980
Astigmatism 164.67 11.50 82 135888 1015 34819946
Suicidal ideation 164.41 11.50 434 135536 39954 34781007
Catatonia 163.18 11.50 144 135826 4881 34816080
Muscle rigidity 163.17 11.50 203 135767 10315 34810646
Dystonia 162.97 11.50 206 135764 10639 34810322
Euphoric mood 162.27 11.50 151 135819 5490 34815471
Blood creatine phosphokinase increased 161.69 11.50 461 135509 44396 34776565
Hallucination, auditory 161.34 11.50 215 135755 11702 34809259
Drug ineffective 160.82 11.50 2578 133392 454173 34366788
Anticonvulsant drug level decreased 159.12 11.50 80 135890 1012 34819949
Gastrointestinal haemorrhage 155.14 11.50 75 135895 88402 34732559
Disinhibition 154.58 11.50 116 135854 3110 34817851
Dyspraxia 151.99 11.50 59 135911 378 34820583
Talipes 151.43 11.50 94 135876 1829 34819132
Motor developmental delay 150.11 11.50 66 135904 602 34820359
Dyskinesia 148.30 11.50 292 135678 22121 34798840
Joint swelling 147.92 11.50 27 135943 59863 34761098
Product substitution issue 145.77 11.50 188 135782 9907 34811054
Treatment noncompliance 145.24 11.50 331 135639 27769 34793192
Obsessive-compulsive disorder 144.95 11.50 141 135829 5423 34815538
Delirium 144.11 11.50 437 135533 43554 34777407
Psychiatric decompensation 143.83 11.50 107 135863 2830 34818131
Product residue present 143.41 11.50 104 135866 2642 34818319
Myoclonic epilepsy 143.34 11.50 76 135894 1081 34819880
Wrong patient received product 141.99 11.50 102 135868 2552 34818409
Mental disorder 141.58 11.50 230 135740 14979 34805982
Asthenia 137.63 11.50 491 135479 244760 34576201
Peripheral swelling 137.08 11.50 63 135907 76478 34744483
Pruritus 136.75 11.50 213 135757 141768 34679193
Cough 135.52 11.50 235 135735 149905 34671056
Encephalopathy 135.15 11.50 371 135599 34948 34786013
Neurodevelopmental disorder 134.47 11.50 54 135916 383 34820578
Cryptorchism 134.07 11.50 89 135881 1952 34819009
Strabismus 132.24 11.50 83 135887 1648 34819313
Learning disability 130.99 11.50 50 135920 304 34820657
Rheumatoid arthritis 130.35 11.50 4 135966 38234 34782727
Altered state of consciousness 129.96 11.50 280 135690 22613 34798348
Interstitial lung disease 129.50 11.50 46 135924 65236 34755725
Infusion related reaction 128.72 11.50 25 135945 53032 34767929
Restlessness 128.20 11.50 297 135673 25185 34795776
Myopia 127.82 11.50 70 135900 1066 34819895
Foot deformity 127.72 11.50 120 135850 4417 34816544
Plasma cell myeloma 125.65 11.50 10 135960 42027 34778934
Communication disorder 124.32 11.50 93 135877 2481 34818480
Renal failure 123.69 11.50 198 135772 130359 34690602
Lip disorder 122.98 11.50 52 135918 427 34820534
Fanconi syndrome 122.75 11.50 79 135891 1641 34819320
Thrombosis 121.94 11.50 24 135946 50434 34770527
Educational problem 121.37 11.50 54 135916 508 34820453
Abdominal pain 120.51 11.50 288 135682 163330 34657631
Joint laxity 120.20 11.50 49 135921 363 34820598
Depressive symptom 117.79 11.50 94 135876 2765 34818196
Schizoaffective disorder 117.69 11.50 70 135900 1257 34819704
Prostate cancer 116.94 11.50 10 135960 39639 34781322
Disorientation 116.59 11.50 338 135632 32850 34788111
Chest pain 116.57 11.50 196 135774 126566 34694395
Hypotonia neonatal 114.23 11.50 69 135901 1276 34819685
Myocarditis 114.13 11.50 197 135773 13485 34807476
Sudden unexplained death in epilepsy 113.18 11.50 49 135921 429 34820532
Congenital oral malformation 113.01 11.50 26 135944 6 34820955
Prescribed overdose 112.96 11.50 171 135799 10476 34810485
Coordination abnormal 112.95 11.50 144 135826 7500 34813461
Drug reaction with eosinophilia and systemic symptoms 112.89 11.50 333 135637 32679 34788282
Dysarthria 111.55 11.50 343 135627 34439 34786522
Increased appetite 111.44 11.50 141 135829 7288 34813673
Sepsis 111.27 11.50 308 135662 166253 34654708
Bradyphrenia 111 11.50 114 135856 4684 34816277
Priapism 110.76 11.50 116 135854 4878 34816083
Myalgia 108.82 11.50 100 135870 84010 34736951
Focal dyscognitive seizures 107.47 11.50 67 135903 1314 34819647
Therapeutic product effect variable 106.02 11.50 83 135887 2373 34818588
Oedema peripheral 105.84 11.50 190 135780 119622 34701339
Hypertonia 105.76 11.50 105 135865 4141 34816820
Anticonvulsant drug level above therapeutic 105.40 11.50 52 135918 630 34820331
Drug level below therapeutic 104.62 11.50 119 135851 5496 34815465
Low set ears 104.30 11.50 46 135924 423 34820538
Oculogyric crisis 103.79 11.50 69 135901 1517 34819444
Pectus excavatum 103.47 11.50 38 135932 204 34820757
Back pain 102.40 11.50 199 135771 121590 34699371
Anticonvulsant drug level below therapeutic 101.98 11.50 50 135920 597 34820364
Congenital foot malformation 100.39 11.50 44 135926 398 34820563
COVID-19 99.38 11.50 93 135877 77457 34743504
Myoclonus 98.80 11.50 193 135777 14532 34806429
Cardiac failure 98.63 11.50 126 135844 91122 34729839
Mucosal inflammation 98.46 11.50 16 135954 38606 34782355
Drooling 98.18 11.50 91 135879 3291 34817670
Scoliosis 96.66 11.50 83 135887 2710 34818251
Antipsychotic drug level above therapeutic 96.40 11.50 60 135910 1173 34819788
Thinking abnormal 96.07 11.50 119 135851 6018 34814943
Hypermetropia 94.03 11.50 44 135926 470 34820491
Congenital hand malformation 93.84 11.50 46 135924 549 34820412
Bipolar disorder 93.74 11.50 92 135878 3577 34817384
Pneumonia aspiration 93.22 11.50 366 135604 41537 34779424
Tonic convulsion 92.78 11.50 58 135912 1143 34819818
Fine motor delay 92.56 11.50 36 135934 232 34820729
Obesity 91.57 11.50 173 135797 12705 34808256
Chills 89.57 11.50 110 135860 80933 34740028
Pulmonary embolism 88.88 11.50 132 135838 89614 34731347
Echolalia 87.71 11.50 36 135934 272 34820689
Dizziness 87.28 11.50 496 135474 218025 34602936
Impulsive behaviour 86.76 11.50 70 135900 2092 34818869
Asterixis 86.43 11.50 56 135914 1177 34819784
Acute myocardial infarction 86.12 11.50 51 135919 53668 34767293
Tearfulness 85.74 11.50 76 135894 2591 34818370
Chest discomfort 85.70 11.50 53 135917 54477 34766484
Ascites 85.45 11.50 37 135933 46534 34774427
Disturbance in social behaviour 85.23 11.50 65 135905 1786 34819175
Psychogenic seizure 84.77 11.50 37 135933 331 34820630
Fine motor skill dysfunction 84.57 11.50 64 135906 1738 34819223
Prominent epicanthal folds 84.26 11.50 30 135940 145 34820816
Blood pressure increased 83.97 11.50 133 135837 87969 34732992
Developmental coordination disorder 83.87 11.50 31 135939 170 34820791
Coronary artery disease 83.04 11.50 42 135928 48263 34772698
Hypomania 81.43 11.50 70 135900 2289 34818672
Ligament laxity 81.10 11.50 20 135950 13 34820948
Affect lability 80.70 11.50 85 135885 3598 34817363
Clinodactyly 79.92 11.50 32 135938 225 34820736
Hypothermia 79.68 11.50 147 135823 10601 34810360
Ear disorder 79.26 11.50 60 135910 1630 34819331
Hyperkalaemia 79.00 11.50 92 135878 69297 34751664
Drug withdrawal convulsions 78.94 11.50 52 135918 1125 34819836
Anger 78.81 11.50 155 135815 11729 34809232
Eosinophilic pleural effusion 78.16 11.50 32 135938 240 34820721
Epistaxis 78.04 11.50 67 135903 58184 34762777
Depression suicidal 77.79 11.50 70 135900 2435 34818526
Sedation complication 76.59 11.50 60 135910 1717 34819244
Oppositional defiant disorder 76.43 11.50 39 135931 510 34820451
Nystagmus 76.35 11.50 93 135877 4622 34816339
Postictal psychosis 76.02 11.50 29 135941 176 34820785
Cytokine release syndrome 75.84 11.50 3 135967 22874 34798087
Dyspnoea exertional 75.35 11.50 37 135933 43242 34777719
Stereotypy 75.19 11.50 43 135927 715 34820246
Headache 75.00 11.50 465 135505 200170 34620791
Personal relationship issue 74.93 11.50 32 135938 270 34820691
Neutrophil count increased 74.62 11.50 189 135781 16957 34804004
Anxiety 73.97 11.50 649 135321 98779 34722182
Renal impairment 73.85 11.50 161 135809 94352 34726609
Eosinophilia 73.54 11.50 247 135723 25975 34794986
Urticaria 72.86 11.50 81 135889 62296 34758665
Microcephaly 72.49 11.50 43 135927 768 34820193
Hypermobility syndrome 72.24 11.50 33 135937 332 34820629
Persecutory delusion 72.16 11.50 68 135902 2512 34818449
Personality disorder 72.08 11.50 49 135921 1119 34819842
Dyslexia 71.83 11.50 32 135938 302 34820659
Atonic seizures 71.41 11.50 30 135940 242 34820719
Congenital anomaly 71.02 11.50 52 135918 1341 34819620
Weight decreased 70.97 11.50 399 135571 175902 34645059
Abdominal pain upper 70.92 11.50 105 135865 71385 34749576
Dysphoria 70.84 11.50 64 135906 2238 34818723
Muscle spasms 70.73 11.50 114 135856 74887 34746074
Serotonin syndrome 69.98 11.50 203 135767 19730 34801231
Stevens-Johnson syndrome 69.51 11.50 194 135776 18445 34802516
Haematochezia 69.36 11.50 48 135922 46486 34774475
Antipsychotic drug level decreased 68.38 11.50 45 135925 972 34819989
Plagiocephaly 67.90 11.50 36 135934 512 34820449
Hypernatraemia 67.89 11.50 120 135850 8370 34812591
Craniosynostosis 67.88 11.50 32 135938 348 34820613
Gaze palsy 67.79 11.50 55 135915 1657 34819304
Toxic encephalopathy 66.94 11.50 92 135878 5157 34815804
Loss of personal independence in daily activities 66.79 11.50 281 135689 32898 34788063
Bipolar I disorder 65.87 11.50 40 135930 747 34820214
Decreased eye contact 65.55 11.50 34 135936 461 34820500
Weight increased 65.47 11.50 600 135370 92433 34728528
Influenza 65.47 11.50 58 135912 49608 34771353
General physical health deterioration 65.19 11.50 267 135703 128002 34692959
Hypersensitivity 65.19 11.50 85 135885 60950 34760011
Psychiatric symptom 64.68 11.50 74 135896 3439 34817522
Fluid retention 64.51 11.50 13 135957 26874 34794087
Pancreatitis acute 64.36 11.50 248 135722 27893 34793068
Ear malformation 64.17 11.50 29 135941 284 34820677
Arthritis 64.03 11.50 21 135949 31325 34789636
Sinusitis 64.00 11.50 41 135929 41361 34779600
Psoriasis 63.41 11.50 36 135934 38776 34782185
Bradykinesia 63.38 11.50 77 135893 3816 34817145
Cerebral atrophy 62.95 11.50 83 135887 4469 34816492
Psychotic symptom 62.78 11.50 53 135917 1690 34819271
Hepatic function abnormal 62.58 11.50 339 135631 44024 34776937
Stupor 62.06 11.50 66 135904 2825 34818136
Herpes zoster 62.05 11.50 28 135942 34371 34786590
Melaena 61.96 11.50 30 135940 35350 34785611
Cerebrovascular accident 61.79 11.50 150 135820 84661 34736300
Erythema 61.59 11.50 161 135809 88619 34732342
Hypoaesthesia 61.18 11.50 90 135880 61354 34759607
Confusional state 60.92 11.50 841 135129 143319 34677642
Leukopenia 60.84 11.50 436 135534 62420 34758541
Brain oedema 60.82 11.50 153 135817 13668 34807293
Septic shock 60.66 11.50 117 135853 71717 34749244
Nasal disorder 60.11 11.50 54 135916 1874 34819087
Nose deformity 59.43 11.50 24 135946 173 34820788
Dehydration 59.11 11.50 282 135688 129687 34691274
Cogwheel rigidity 59.03 11.50 46 135924 1306 34819655
Excessive eye blinking 58.93 11.50 33 135937 526 34820435
Motor dysfunction 58.92 11.50 101 135869 6873 34814088
Rash 58.49 11.50 569 135401 222183 34598778
Syncope 57.41 11.50 174 135796 91277 34729684
Exposure during pregnancy 57.40 11.50 115 135855 8819 34812142
Encopresis 57.29 11.50 23 135947 163 34820798
Pressure of speech 57.07 11.50 31 135939 464 34820497
White blood cell count increased 57.06 11.50 313 135657 40838 34780123
Asocial behaviour 56.73 11.50 18 135952 56 34820905
Mental status changes 56.43 11.50 295 135675 37788 34783173
Haemoptysis 56.43 11.50 33 135937 34973 34785988
Pancytopenia 56.27 11.50 186 135784 94971 34725990
Blood creatinine increased 55.91 11.50 186 135784 94790 34726171
Angina pectoris 55.83 11.50 26 135944 31337 34789624
Completed suicide 55.46 11.50 605 135365 97563 34723398
Brugada syndrome 55.22 11.50 36 135934 765 34820196
Basal cell carcinoma 55.21 11.50 6 135964 19652 34801309
Arthropathy 55 11.50 18 135952 26889 34794072
Atrial septal defect 54.67 11.50 101 135869 7291 34813670
Musculoskeletal pain 54.62 11.50 28 135942 31935 34789026
Hyperacusis 54.50 11.50 37 135933 843 34820118
Rectal haemorrhage 54.26 11.50 46 135924 40203 34780758
Upper gastrointestinal haemorrhage 54.08 11.50 16 135954 25502 34795459
Paraesthesia 53.76 11.50 105 135865 64067 34756894
Malaise 53.38 11.50 464 135506 185361 34635600
Pneumonitis 53.12 11.50 33 135937 33845 34787116
Congenital eye disorder 53.04 11.50 20 135950 117 34820844
Social avoidant behaviour 53.00 11.50 63 135907 3051 34817910
Swelling 52.86 11.50 52 135918 42314 34778647
Abdominal discomfort 52.68 11.50 95 135875 59740 34761221
Hyperkinesia 52.15 11.50 48 135922 1720 34819241
Differential white blood cell count abnormal 51.80 11.50 44 135926 1415 34819546
Reading disorder 51.57 11.50 30 135940 516 34820445
Osteonecrosis of jaw 51.43 11.50 5 135965 17884 34803077
Posture abnormal 51.43 11.50 53 135917 2186 34818775
Lethargy 51.25 11.50 304 135666 40818 34780143
Diabetes insipidus 51.10 11.50 60 135910 2868 34818093
Drug level changed 51.09 11.50 26 135944 338 34820623
Knee deformity 50.95 11.50 32 135938 636 34820325
Chronic kidney disease 50.93 11.50 51 135919 41159 34779802
Psoriatic arthropathy 50.91 11.50 8 135962 19790 34801171
Multiple congenital abnormalities 50.66 11.50 30 135940 534 34820427
Hyperprolactinaemia 50.35 11.50 45 135925 1551 34819410
Camptodactyly congenital 50.27 11.50 19 135951 112 34820849
Anaphylactic reaction 49.91 11.50 32 135938 32269 34788692
Urinary incontinence 49.60 11.50 174 135796 18700 34802261
Arnold-Chiari malformation 48.85 11.50 25 135945 329 34820632
High arched palate 48.58 11.50 16 135954 58 34820903
Homicidal ideation 48.55 11.50 56 135914 2626 34818335
Cerebellar atrophy 48.55 11.50 29 135941 525 34820436
Pneumocystis jirovecii pneumonia 48.40 11.50 9 135961 19701 34801260
Faecaloma 48.25 11.50 80 135890 5297 34815664
Sleep disorder 48.01 11.50 247 135723 31441 34789520
Ear infection 47.92 11.50 116 135854 10115 34810846
Spina bifida 47.88 11.50 25 135945 344 34820617
Injection site pain 47.38 11.50 49 135921 38956 34782005
Emotional disorder 47.27 11.50 82 135888 5634 34815327
Bruxism 47.13 11.50 45 135925 1690 34819271
Congenital eyelid malformation 47.12 11.50 17 135953 86 34820875
Cerebral ventricle dilatation 46.87 11.50 35 135935 931 34820030
Apraxia 46.27 11.50 40 135930 1318 34819643
Cytomegalovirus infection 46.01 11.50 22 135948 26113 34794848
Physical assault 45.79 11.50 37 135933 1108 34819853
Stomatitis 45.60 11.50 59 135911 42455 34778506
Congenital hair disorder 45.53 11.50 10 135960 0 34820961
Product dose omission issue 45.42 11.50 276 135694 119435 34701526
Head titubation 45.34 11.50 25 135945 386 34820575
Hyperosmolar state 45.23 11.50 25 135945 388 34820573
Executive dysfunction 45.15 11.50 21 135949 221 34820740
Gait disturbance 45.03 11.50 518 135452 84622 34736339
Pancreatitis 44.35 11.50 281 135689 38610 34782351
Autonomic nervous system imbalance 44.06 11.50 52 135918 2499 34818462
Haemorrhage 43.94 11.50 83 135887 51287 34769674
Tumour lysis syndrome 43.62 11.50 7 135963 17052 34803909
Neoplasm progression 43.55 11.50 18 135952 23282 34797679
Torticollis 43.44 11.50 36 135934 1118 34819843
Tooth malformation 43.34 11.50 19 135951 172 34820789
Heart rate decreased 43.13 11.50 36 135934 31709 34789252
Synovitis 43.01 11.50 3 135967 14063 34806898
Palmar-plantar erythrodysaesthesia syndrome 42.71 11.50 7 135963 16788 34804173
Normal pressure hydrocephalus 42.68 11.50 19 135951 179 34820782
Pleurothotonus 42.09 11.50 36 135934 1169 34819792
Angioedema 42.04 11.50 50 135920 37324 34783637
Haematuria 41.86 11.50 82 135888 49984 34770977
Chorea 41.83 11.50 35 135935 1102 34819859
Transient ischaemic attack 41.79 11.50 28 135942 27585 34793376
Choreoathetosis 41.75 11.50 34 135936 1030 34819931
Nipple disorder 41.61 11.50 19 135951 191 34820770
Seizure cluster 41.24 11.50 17 135953 130 34820831
Logorrhoea 41.16 11.50 49 135921 2377 34818584
Confabulation 41.13 11.50 17 135953 131 34820830
Blood prolactin increased 41.04 11.50 42 135928 1718 34819243
Bronchiolitis 41 11.50 56 135914 3120 34817841
Colitis 40.89 11.50 52 135918 37698 34783263
Homicide 40.81 11.50 32 135938 917 34820044
Cellulitis 40.68 11.50 91 135879 52860 34768101
Eosinophil count decreased 40.63 11.50 38 135932 1390 34819571
Memory impairment 40.48 11.50 298 135672 43020 34777941
Pyrexia 40.09 11.50 988 134982 332025 34488936
Dysgeusia 39.92 11.50 27 135943 26470 34794491
Apathy 39.57 11.50 85 135885 6847 34814114
Acute myeloid leukaemia 39.56 11.50 11 135959 18259 34802702
Oedema 39.04 11.50 74 135896 45667 34775294
Anisometropia 38.87 11.50 13 135957 50 34820911
Necrosis ischaemic 38.51 11.50 20 135950 272 34820689
Osteoarthritis 38.50 11.50 16 135954 20626 34800335
Congenital myopia 38.46 11.50 14 135956 73 34820888
Dry skin 38.34 11.50 39 135931 31248 34789713
Inappropriate antidiuretic hormone secretion 38.32 11.50 123 135847 12630 34808331
Flushing 37.95 11.50 42 135928 32378 34788583
Sexually inappropriate behaviour 37.73 11.50 24 135946 488 34820473
Abdominal distension 37.62 11.50 110 135860 58382 34762579
Bronchopulmonary aspergillosis 37.52 11.50 6 135964 14653 34806308
Lung disorder 37.36 11.50 48 135922 34648 34786313
Bacteraemia 37.23 11.50 15 135955 19702 34801259
Full blood count decreased 37.14 11.50 12 135958 18076 34802885
COVID-19 pneumonia 37.14 11.50 10 135960 16957 34804004
Crying 37.11 11.50 75 135895 5787 34815174
Respiratory failure 36.78 11.50 259 135711 108313 34712648
Delusional disorder, unspecified type 36.49 11.50 27 135943 708 34820253
Drug resistance 36.47 11.50 198 135772 25729 34795232
Carnitine decreased 36.43 11.50 8 135962 0 34820961
Cardiogenic shock 36.39 11.50 30 135940 26588 34794373
Flight of ideas 36.36 11.50 21 135949 356 34820605
Drug intolerance 36.19 11.50 115 135855 59455 34761506
Monocyte count increased 35.87 11.50 65 135905 4622 34816339
Acidosis hyperchloraemic 35.76 11.50 22 135948 421 34820540
Hypokalaemia 35.64 11.50 112 135858 58102 34762859
Infantile spasms 35.42 11.50 17 135953 193 34820768
Intelligence test abnormal 35.31 11.50 10 135960 18 34820943
Pneumothorax 35.28 11.50 15 135955 19077 34801884
Mood altered 35.18 11.50 95 135875 8857 34812104
Blood pressure fluctuation 35.09 11.50 28 135942 25221 34795740
International normalised ratio increased 35.01 11.50 83 135887 47244 34773717
Pulmonary fibrosis 34.73 11.50 14 135956 18382 34802579
Emotional disorder of childhood 34.72 11.50 11 135959 34 34820927
Laboratory test abnormal 34.63 11.50 18 135952 20373 34800588
Social (pragmatic) communication disorder 34.48 11.50 13 135957 76 34820885
Visuospatial deficit 34.20 11.50 14 135956 105 34820856
Dyslipidaemia 34.11 11.50 84 135886 7404 34813557
Dyscalculia 34.06 11.50 13 135957 79 34820882
Congenital nail disorder 34.03 11.50 11 135959 37 34820924
Coloboma 34.00 11.50 15 135955 138 34820823
Soliloquy 33.94 11.50 21 135949 406 34820555
Heart disease congenital 33.93 11.50 34 135936 1356 34819605
Arachnodactyly 33.89 11.50 8 135962 3 34820958
Distractibility 33.87 11.50 20 135950 354 34820607
Manic symptom 33.86 11.50 14 135956 108 34820853
Chronic obstructive pulmonary disease 33.69 11.50 89 135881 48829 34772132
Prognathism 33.42 11.50 14 135956 112 34820849
Refraction disorder 33.37 11.50 11 135959 40 34820921
Renal disorder 33.28 11.50 30 135940 25450 34795511
Infection 33.23 11.50 212 135758 90703 34730258
Pharyngeal disorder 33.22 11.50 26 135944 743 34820218
Night sweats 33.09 11.50 13 135957 17339 34803622
Congenital knee deformity 32.79 11.50 14 135956 118 34820843
Inflammation 32.74 11.50 37 135933 28258 34792703
Myelosuppression 32.73 11.50 17 135953 19248 34801713
Haemoglobin decreased 32.70 11.50 306 135664 120466 34700495
Bone pain 32.63 11.50 20 135950 20666 34800295
Nephrolithiasis 32.63 11.50 42 135928 30291 34790670
Atrial flutter 32.57 11.50 10 135960 15564 34805397
Illiteracy 32.56 11.50 8 135962 5 34820956
Hepatic adenoma 32.55 11.50 11 135959 44 34820917
Drop attacks 32.55 11.50 23 135947 560 34820401
Drug hypersensitivity 32.48 11.50 182 135788 80347 34740614
Antisocial behaviour 32.31 11.50 20 135950 387 34820574
Hot flush 32.12 11.50 15 135955 18051 34802910
Inguinal hernia 31.97 11.50 83 135887 7558 34813403
Self-injurious ideation 31.90 11.50 36 135934 1648 34819313
Drug abuse 31.80 11.50 552 135418 98544 34722417
Neoplasm malignant 31.74 11.50 19 135951 19886 34801075
Postictal paralysis 31.74 11.50 17 135953 247 34820714
Staphylococcal infection 31.62 11.50 49 135921 32711 34788250
Paradoxical drug reaction 31.62 11.50 51 135919 3300 34817661
Acute coronary syndrome 31.56 11.50 7 135963 13538 34807423
Affective disorder 31.52 11.50 59 135911 4301 34816660
Retinal coloboma 31.50 11.50 9 135961 17 34820944
Nasal septum disorder 31.44 11.50 11 135959 50 34820911
Perseveration 31.36 11.50 13 135957 101 34820860
Anticonvulsant drug level abnormal 31.08 11.50 10 135960 33 34820928
Frequent bowel movements 31.05 11.50 6 135964 12781 34808180
Febrile convulsion 31.05 11.50 23 135947 604 34820357
Social problem 31.04 11.50 27 135943 897 34820064
Inappropriate affect 30.87 11.50 24 135946 679 34820282
Growth retardation 30.82 11.50 37 135933 1811 34819150
Hallucination, visual 30.75 11.50 144 135826 17647 34803314
Localised infection 30.66 11.50 15 135955 17572 34803389
Sluggishness 30.64 11.50 50 135920 3267 34817694
Retrognathia 30.52 11.50 17 135953 268 34820693
Nasopharyngitis 30.51 11.50 154 135816 69814 34751147
Rash pruritic 30.34 11.50 36 135934 26905 34794056
Rhinorrhoea 30.32 11.50 33 135937 25635 34795326
Lymphocyte count increased 30.11 11.50 50 135920 3315 34817646
Blood pressure systolic increased 30 11.50 27 135943 22925 34798036
Oligoasthenozoospermia 29.98 11.50 8 135962 10 34820951
Congenital astigmatism 29.96 11.50 11 135959 59 34820902
Congenital genital malformation 29.88 11.50 14 135956 150 34820811
Phobia 29.88 11.50 14 135956 150 34820811
Developmental hip dysplasia 29.45 11.50 17 135953 288 34820673
Intentional product use issue 29.43 11.50 126 135844 59690 34761271
Deep vein thrombosis 29.38 11.50 142 135828 65106 34755855
Muscle tone disorder 29.32 11.50 14 135956 157 34820804
Angina unstable 29.31 11.50 5 135965 11648 34809313
Dysmetria 29.30 11.50 22 135948 590 34820371
Toe walking 29.14 11.50 8 135962 12 34820949
Hypotension 29.00 11.50 649 135321 221000 34599961
Decreased appetite 28.92 11.50 464 135506 165928 34655033
Otitis media 28.88 11.50 45 135925 2827 34818134
Neural tube defect 28.84 11.50 10 135960 44 34820917
Feeling hot 28.83 11.50 20 135950 19352 34801609
Postictal state 28.46 11.50 25 135945 842 34820119
Anion gap increased 28.45 11.50 36 135934 1860 34819101
Metastases to bone 28.27 11.50 6 135964 11964 34808997
Gastrointestinal malformation 28.27 11.50 11 135959 71 34820890
Amblyopia 28.23 11.50 12 135958 100 34820861
Tachycardia 28.20 11.50 475 135495 84297 34736664
Limb hypoplasia congenital 28.04 11.50 8 135962 15 34820946
Frustration tolerance decreased 27.97 11.50 42 135928 2554 34818407
Gross motor delay 27.92 11.50 17 135953 319 34820642
Partial seizures with secondary generalisation 27.92 11.50 17 135953 319 34820642
Meningocele 27.90 11.50 9 135961 30 34820931
Mutism 27.77 11.50 25 135945 870 34820091
Neuralgia 27.73 11.50 12 135958 15101 34805860
Unresponsive to stimuli 27.68 11.50 193 135777 27376 34793585
Muscular weakness 27.66 11.50 168 135802 72729 34748232
Middle insomnia 27.56 11.50 73 135897 6729 34814232
Coma scale abnormal 27.45 11.50 53 135917 3955 34817006
Congenital neurological disorder 27.32 11.50 6 135964 0 34820961
Factor XIII deficiency 27.32 11.50 6 135964 0 34820961
Cholestasis 27.28 11.50 39 135931 26909 34794052
Convulsive threshold lowered 27.24 11.50 20 135950 518 34820443
Pulmonary mass 27.21 11.50 8 135962 12804 34808157
Anaphylactic shock 27.18 11.50 14 135956 15927 34805034
Judgement impaired 27.10 11.50 21 135949 591 34820370
Speech sound disorder 27.06 11.50 13 135957 148 34820813
Duodenal ulcer 26.96 11.50 4 135966 10328 34810633
Scaphocephaly 26.77 11.50 8 135962 19 34820942
Intensive care unit acquired weakness 26.70 11.50 26 135944 1001 34819960
Metabolic syndrome 26.68 11.50 33 135937 1666 34819295
Clostridium difficile colitis 26.55 11.50 14 135956 15716 34805245
Hyperthermia 26.50 11.50 96 135874 10481 34810480
Balance disorder 26.47 11.50 258 135712 40396 34780565
Agranulocytosis 26.46 11.50 171 135799 23650 34797311
Post-injection delirium sedation syndrome 26.46 11.50 19 135951 475 34820486
Flatulence 26.46 11.50 26 135944 21172 34799789
Ventricular tachycardia 26.38 11.50 39 135931 26540 34794421
Aphasia 26.33 11.50 158 135812 21296 34799665
Hypotelorism of orbit 26.25 11.50 12 135958 121 34820840
Constipation 26.19 11.50 375 135595 136607 34684354
Cleft palate 26.13 11.50 21 135949 624 34820337
Hypervolaemia 25.98 11.50 23 135947 19686 34801275
Gout 25.95 11.50 22 135948 19231 34801730
Deformity thorax 25.88 11.50 9 135961 40 34820921
Impaired reasoning 25.82 11.50 12 135958 126 34820835
Choking 25.81 11.50 59 135911 4956 34816005
Angular cheilitis 25.75 11.50 13 135957 166 34820795
Congenital scoliosis 25.74 11.50 11 135959 93 34820868
Oesophageal carcinoma 25.72 11.50 3 135967 9301 34811660
Renal injury 25.66 11.50 6 135964 11189 34809772
Bicuspid aortic valve 25.57 11.50 14 135956 213 34820748
Staring 25.45 11.50 30 135940 1440 34819521
Device related infection 25.39 11.50 18 135952 17219 34803742
Dacryostenosis congenital 25.36 11.50 9 135961 43 34820918
Resting tremor 25.10 11.50 21 135949 661 34820300
Tonic clonic movements 25.01 11.50 25 135945 994 34819967
Urinary tract infection 24.97 11.50 208 135762 83873 34737088
Strabismus congenital 24.95 11.50 8 135962 26 34820935
Osteomyelitis 24.90 11.50 16 135954 16120 34804841
Choroidal coloboma 24.90 11.50 6 135964 3 34820958
Microstomia 24.90 11.50 6 135964 3 34820958
Depressed mood 24.83 11.50 144 135826 19173 34801788
Blood potassium decreased 24.73 11.50 20 135950 17895 34803066
Nephropathy toxic 24.72 11.50 9 135961 12579 34808382
Cerebral palsy 24.72 11.50 12 135958 140 34820821
Tic 24.64 11.50 35 135935 2023 34818938
Blood bilirubin increased 24.64 11.50 72 135898 38224 34782737
Myelodysplastic syndrome 24.63 11.50 23 135947 19185 34801776
Pulmonary hypertension 24.61 11.50 27 135943 20897 34800064
Anomaly of external ear congenital 24.58 11.50 11 135959 105 34820856
Metabolic acidosis 24.54 11.50 269 135701 43411 34777550
Food interaction 24.54 11.50 24 135946 929 34820032
Medication error 24.52 11.50 177 135793 25388 34795573
Negativism 24.49 11.50 17 135953 402 34820559
Wrong product administered 24.47 11.50 60 135910 5274 34815687
Lymphoma 24.47 11.50 9 135961 12498 34808463
Adrenal insufficiency 24.46 11.50 12 135958 14035 34806926
Acute hepatic failure 24.38 11.50 114 135856 13960 34807001
Hernia 24.35 11.50 4 135966 9579 34811382
Cardiac disorder 24.31 11.50 86 135884 43040 34777921
Shock haemorrhagic 24.27 11.50 7 135963 11347 34809614
Intestinal ischaemia 24.17 11.50 76 135894 7718 34813243
Water intoxication 24.17 11.50 17 135953 411 34820550
Pneumonia bacterial 24.16 11.50 8 135962 11864 34809097
Foetal growth restriction 24.10 11.50 51 135919 4066 34816895
Delusion of grandeur 24.05 11.50 26 135944 1134 34819827
Drug level above therapeutic 24.04 11.50 52 135918 4209 34816752
Faeces discoloured 24.01 11.50 14 135956 14864 34806097
Selective eating disorder 23.94 11.50 32 135938 1746 34819215
Inappropriate schedule of product administration 23.93 11.50 143 135827 62153 34758808
Ventricular septal defect 23.93 11.50 50 135920 3951 34817010
Overweight 23.91 11.50 33 135937 1857 34819104
Patient isolation 23.87 11.50 8 135962 31 34820930
Change in seizure presentation 23.85 11.50 12 135958 152 34820809
Failure to suspend medication 23.81 11.50 17 135953 421 34820540
Clostridium difficile infection 23.79 11.50 23 135947 18875 34802086
Cerebral infarction 23.79 11.50 44 135926 27411 34793550
Schizoaffective disorder bipolar type 23.71 11.50 11 135959 115 34820846
C-reactive protein abnormal 23.61 11.50 3 135967 8707 34812254
Mood swings 23.55 11.50 76 135894 7825 34813136
Pelvic deformity 23.54 11.50 9 135961 55 34820906
Leukaemia 23.52 11.50 54 135916 4549 34816412
Brain malformation 23.44 11.50 12 135958 158 34820803
Eosinophil count increased 23.37 11.50 80 135890 8492 34812469
Grandiosity 23.24 11.50 15 135955 313 34820648
Retinogram abnormal 23.15 11.50 11 135959 122 34820839
Presyncope 23.08 11.50 24 135946 19035 34801926
Head discomfort 22.96 11.50 50 135920 4066 34816895
Incontinence 22.93 11.50 62 135908 5785 34815176
Illness 22.89 11.50 12 135958 13517 34807444
Squamous cell carcinoma 22.89 11.50 8 135962 11467 34809494
Hypertension 22.87 11.50 383 135587 136060 34684901
Squamous cell carcinoma of skin 22.73 11.50 7 135963 10874 34810087
Transplant rejection 22.71 11.50 6 135964 10305 34810656
Skin cancer 22.67 11.50 6 135964 10291 34810670
Patent ductus arteriosus 22.54 11.50 44 135926 3310 34817651
Porphyria acute 22.47 11.50 15 135955 332 34820629
Poverty of speech 22.38 11.50 13 135957 223 34820738
Rhabdomyolysis 22.32 11.50 381 135589 67782 34753179
Diverticulitis 22.24 11.50 27 135943 19977 34800984
Blood lactic acid increased 22.16 11.50 67 135903 6661 34814300
Salivary gland enlargement 22.01 11.50 7 135963 22 34820939
Hallucination 21.93 11.50 301 135669 51197 34769764
Pleural effusion 21.89 11.50 207 135763 81339 34739622
Blood osmolarity decreased 21.89 11.50 18 135952 553 34820408
Mucosal ulceration 21.86 11.50 23 135947 972 34819989
Congenital nipple anomaly 21.86 11.50 6 135964 9 34820952
Febrile bone marrow aplasia 21.84 11.50 3 135967 8206 34812755
Candida infection 21.80 11.50 22 135948 17693 34803268
Throat irritation 21.77 11.50 7 135963 10578 34810383
Haemorrhoids 21.75 11.50 15 135955 14560 34806401
Clonic convulsion 21.75 11.50 19 135951 635 34820326
Head deformity 21.70 11.50 9 135961 70 34820891
Brachydactyly 21.56 11.50 12 135958 189 34820772
Cerebral haemorrhage 21.53 11.50 67 135903 34870 34786091
Contusion 21.53 11.50 71 135899 36293 34784668
Basilar artery occlusion 21.49 11.50 9 135961 72 34820889
Lennox-Gastaut syndrome 21.48 11.50 8 135962 45 34820916
Micrognathia 21.37 11.50 14 135956 300 34820661
Impaired healing 21.31 11.50 17 135953 15317 34805644
Carnitine deficiency 21.27 11.50 10 135960 108 34820853
Enterocolitis 21.19 11.50 3 135967 8023 34812938
Diabetic hyperosmolar coma 21.19 11.50 16 135954 433 34820528
Blood triglycerides increased 21.18 11.50 110 135860 14049 34806912
Skin exfoliation 21.18 11.50 47 135923 27385 34793576
Meningomyelocele 21.17 11.50 12 135958 196 34820765
Hyponatraemia 21.16 11.50 445 135525 82246 34738715
Niemann-Pick disease 21.11 11.50 6 135964 11 34820950
Wheezing 21.11 11.50 86 135884 41316 34779645
Appendicitis 21.11 11.50 16 135954 14791 34806170
Bone marrow failure 21.08 11.50 52 135918 29201 34791760
Renal tubular necrosis 21.03 11.50 18 135952 15662 34805299
Venoocclusive liver disease 20.98 11.50 3 135967 7963 34812998
Cataract 20.94 11.50 44 135926 26142 34794819
Ageusia 20.88 11.50 7 135963 10301 34810660
Haemangioma 20.88 11.50 31 135939 1866 34819095
Epidermolysis bullosa 20.80 11.50 10 135960 114 34820847
Neutropenic sepsis 20.77 11.50 14 135956 13753 34807208
Blood glucose increased 20.74 11.50 163 135807 66555 34754406
Automatism 20.72 11.50 10 135960 115 34820846
Skin ulcer 20.71 11.50 34 135936 22182 34798779
Heterophoria 20.57 11.50 9 135961 81 34820880
Aptyalism 20.55 11.50 15 135955 385 34820576
Adenoidectomy 20.50 11.50 10 135960 118 34820843
Bronchopulmonary disease 20.43 11.50 5 135965 3 34820958
Gastric volvulus 20.43 11.50 5 135965 3 34820958
Gingival hypertrophy 20.39 11.50 30 135940 1791 34819170
Oropharyngeal discomfort 20.36 11.50 41 135929 3155 34817806
Delusional perception 20.29 11.50 11 135959 164 34820797
Decreased gait velocity 20.29 11.50 11 135959 164 34820797
Withdrawal syndrome 20.21 11.50 99 135871 12356 34808605
Necrotising colitis 20.17 11.50 23 135947 1065 34819896
Hyperexplexia 20.15 11.50 7 135963 31 34820930
Pain in jaw 20.03 11.50 13 135957 13027 34807934
Disorganised speech 20.03 11.50 21 135949 884 34820077
Graft versus host disease 20.02 11.50 8 135962 10561 34810400
Dermatitis 19.94 11.50 6 135964 9462 34811499
Joint hyperextension 19.92 11.50 10 135960 126 34820835
Lower gastrointestinal haemorrhage 19.89 11.50 6 135964 9446 34811515
Body dysmorphic disorder 19.85 11.50 10 135960 127 34820834
Hypoxia 19.85 11.50 129 135841 54966 34765995
Injection site swelling 19.84 11.50 10 135960 11517 34809444
Madarosis 19.72 11.50 12 135958 225 34820736
Thought blocking 19.72 11.50 10 135960 129 34820832
Rebound effect 19.68 11.50 41 135929 3233 34817728
Trismus 19.60 11.50 35 135935 2460 34818501
Brain stem auditory evoked response abnormal 19.59 11.50 6 135964 16 34820945
Echopraxia 19.59 11.50 6 135964 16 34820945
Stress 19.56 11.50 57 135913 30290 34790671
Dyspepsia 19.56 11.50 75 135895 36657 34784304
Developmental regression 19.47 11.50 7 135963 35 34820926
Ehlers-Danlos syndrome 19.47 11.50 7 135963 35 34820926
Sensory integrative dysfunction 19.47 11.50 7 135963 35 34820926
Condition aggravated 19.47 11.50 924 135046 191272 34629689
Hostility 19.35 11.50 20 135950 828 34820133
Kyphosis congenital 19.32 11.50 5 135965 5 34820956
Supernumerary nipple 19.31 11.50 7 135963 36 34820925
Erectile dysfunction 19.29 11.50 142 135828 20495 34800466
Bronchiectasis 19.26 11.50 7 135963 9794 34811167
Metastases to liver 19.18 11.50 15 135955 13648 34807313
Cytopenia 19.12 11.50 13 135957 12710 34808251
Subacute endocarditis 19.10 11.50 8 135962 64 34820897
IVth nerve disorder 19.07 11.50 6 135964 18 34820943
Hypomagnesaemia 18.95 11.50 35 135935 21816 34799145
Neutrophil Pelger-Huet anomaly present 18.91 11.50 12 135958 243 34820718
Diffuse large B-cell lymphoma 18.90 11.50 3 135967 7367 34813594
Mental disability 18.89 11.50 8 135962 66 34820895
Tendonitis 18.88 11.50 6 135964 9134 34811827
Iris coloboma 18.83 11.50 6 135964 19 34820942
Dopamine dysregulation syndrome 18.80 11.50 15 135955 441 34820520
Drug ineffective for unapproved indication 18.75 11.50 157 135813 23558 34797403
Otitis media acute 18.73 11.50 17 135953 598 34820363
Myoglobinuria 18.73 11.50 19 135951 769 34820192
Circadian rhythm sleep disorder 18.71 11.50 15 135955 444 34820517
Injection site reaction 18.68 11.50 14 135956 13019 34807942
Poor sucking reflex 18.63 11.50 13 135957 310 34820651
Sperm concentration decreased 18.63 11.50 10 135960 146 34820815
Hepatic cirrhosis 18.59 11.50 24 135946 17290 34803671
Ammonia abnormal 18.58 11.50 8 135962 69 34820892
Verbal abuse 18.52 11.50 11 135959 197 34820764
Energy increased 18.44 11.50 24 135946 1276 34819685
Hyperthyroidism 18.43 11.50 9 135961 10557 34810404
Hyporeflexia 18.42 11.50 30 135940 1957 34819004
Type 2 diabetes mellitus 18.37 11.50 116 135854 15916 34805045
Jaundice 18.36 11.50 63 135907 31819 34789142
Eating disorder 18.33 11.50 72 135898 8168 34812793
Gastric disorder 18.31 11.50 13 135957 12428 34808533
Coma blister 18.29 11.50 8 135962 72 34820889
Cholelithiasis 18.23 11.50 34 135936 21114 34799847
Laryngeal web 18.21 11.50 4 135966 0 34820961
Retracted nipple 18.21 11.50 4 135966 0 34820961
Dentofacial anomaly 18.21 11.50 4 135966 0 34820961
Ear, nose and throat examination abnormal 18.21 11.50 4 135966 0 34820961
Mentally late developer 18.21 11.50 4 135966 0 34820961
Injection site erythema 18.17 11.50 21 135949 15878 34805083
Throat tightness 18.15 11.50 5 135965 8353 34812608
Taste disorder 18.15 11.50 3 135967 7152 34813809
Nephrogenic diabetes insipidus 18.13 11.50 24 135946 1297 34819664
Suspiciousness 18.07 11.50 13 135957 326 34820635
Diabetic coma 18.05 11.50 20 135950 897 34820064
Postural tremor 18.00 11.50 13 135957 328 34820633
Aura 17.97 11.50 13 135957 329 34820632
Polydipsia 17.92 11.50 44 135926 3871 34817090
Chromaturia 17.90 11.50 18 135952 14502 34806459
Tonsillitis 17.85 11.50 33 135937 2383 34818578
Off label use 17.82 11.50 1398 134572 418126 34402835
Kyphosis 17.81 11.50 23 135947 1213 34819748
Compensatory sweating 17.76 11.50 6 135964 24 34820937
Metastases to lung 17.74 11.50 7 135963 9313 34811648
Drug withdrawal syndrome 17.70 11.50 135 135835 19699 34801262
Immune reconstitution inflammatory syndrome 17.65 11.50 6 135964 8753 34812208
Pulmonary arterial hypertension 17.59 11.50 6 135964 8733 34812228
Maternal drugs affecting foetus 17.55 11.50 44 135926 3921 34817040
Mydriasis 17.55 11.50 65 135905 7172 34813789
Hyperhomocysteinaemia 17.54 11.50 11 135959 218 34820743
Movement disorder 17.53 11.50 94 135876 12154 34808807
Aminoaciduria 17.50 11.50 12 135958 278 34820683
Enteritis 17.44 11.50 5 135965 8137 34812824
Simple partial seizures 17.43 11.50 12 135958 280 34820681
Hepatitis C virus test positive 17.40 11.50 13 135957 346 34820615
Tachyphrenia 17.33 11.50 23 135947 1246 34819715
Conversion disorder 17.30 11.50 13 135957 349 34820612
Product administered to patient of inappropriate age 17.25 11.50 39 135931 3252 34817709
Ankyloglossia congenital 17.24 11.50 12 135958 285 34820676
School refusal 17.20 11.50 6 135964 27 34820934
Ventricular fibrillation 17.18 11.50 40 135930 22914 34798047
Brachycephaly 17.13 11.50 8 135962 85 34820876
Congenital inguinal hernia 17.09 11.50 10 135960 174 34820787
Wrist deformity 17.08 11.50 13 135957 356 34820605
Craniofacial deformity 17.05 11.50 8 135962 86 34820875
Rebound psychosis 17.04 11.50 10 135960 175 34820786
Sarcopenia 17.03 11.50 14 135956 430 34820531
Syndactyly 17.02 11.50 19 135951 859 34820102
Cardiac failure acute 16.98 11.50 10 135960 10560 34810401
Hypokinesia 16.93 11.50 74 135896 8806 34812155
Heart rate irregular 16.88 11.50 22 135948 15785 34805176
Diarrhoea haemorrhagic 16.80 11.50 3 135967 6761 34814200
Peripheral sensory neuropathy 16.78 11.50 3 135967 6757 34814204
Conjunctival hyperaemia 16.74 11.50 32 135938 2370 34818591
Coronary artery occlusion 16.74 11.50 11 135959 10951 34810010
Kidney malformation 16.69 11.50 10 135960 182 34820779
Cardiac failure chronic 16.58 11.50 5 135965 7874 34813087
Dementia with Lewy bodies 16.56 11.50 17 135953 698 34820263
Type 1 diabetes mellitus 16.55 11.50 45 135925 4213 34816748
Anxiety disorder 16.51 11.50 27 135943 1767 34819194
Neurological decompensation 16.51 11.50 36 135934 2930 34818031
Seasonal allergy 16.49 11.50 3 135967 6672 34814289
Gastric ulcer 16.49 11.50 22 135948 15628 34805333
Pancreatic carcinoma 16.44 11.50 7 135963 8894 34812067
Embolism 16.42 11.50 5 135965 7824 34813137
Irregular sleep phase 16.30 11.50 7 135963 60 34820901
Pulmonary oedema 16.26 11.50 113 135857 47416 34773545
Incoherent 16.26 11.50 46 135924 4406 34816555
Accidental death 16.24 11.50 32 135938 2424 34818537
Congenital cerebral cyst 16.15 11.50 5 135965 14 34820947
Epileptic aura 16.15 11.50 5 135965 14 34820947
Oral candidiasis 16.12 11.50 14 135956 12096 34808865
Device issue 16.06 11.50 9 135961 9768 34811193
Hypercalcaemia 16.04 11.50 22 135948 15446 34805515
Hyperglycinaemia 15.99 11.50 4 135966 3 34820958
Testicular operation 15.99 11.50 4 135966 3 34820958
Congenital jaw malformation 15.99 11.50 4 135966 3 34820958
Mitochondrial DNA mutation 15.99 11.50 4 135966 3 34820958
Separation anxiety disorder 15.99 11.50 4 135966 3 34820958
Nocturia 15.93 11.50 10 135960 10200 34810761
Gastrointestinal adenocarcinoma 15.91 11.50 7 135963 64 34820897
Sinus disorder 15.84 11.50 4 135966 7081 34813880
Delayed fontanelle closure 15.79 11.50 6 135964 36 34820925
Pasteurella infection 15.79 11.50 6 135964 36 34820925
Dysphonia 15.75 11.50 43 135927 23340 34797621
Pancreatitis haemorrhagic 15.73 11.50 12 135958 330 34820631
Blood urea decreased 15.72 11.50 20 135950 1039 34819922
Opsoclonus myoclonus 15.72 11.50 7 135963 66 34820895
Limb discomfort 15.67 11.50 12 135958 11035 34809926
Urosepsis 15.63 11.50 16 135954 12783 34808178
Abnormal palmar/plantar creases 15.57 11.50 10 135960 207 34820754
Small intestinal obstruction 15.56 11.50 21 135949 14845 34806116
Excessive masturbation 15.52 11.50 8 135962 107 34820854
Phimosis 15.50 11.50 18 135952 850 34820111
Intermittent explosive disorder 15.46 11.50 4 135966 4 34820957
Abnormal labour affecting foetus 15.43 11.50 5 135965 17 34820944
Epileptic psychosis 15.43 11.50 5 135965 17 34820944
Auditory disorder 15.42 11.50 11 135959 272 34820689
Dissociation 15.32 11.50 25 135945 1633 34819328
Camptocormia 15.31 11.50 9 135961 158 34820803
Electrocardiogram QT prolonged 15.31 11.50 234 135736 40718 34780243
Fungal infection 15.22 11.50 24 135946 15911 34805050
Reproductive tract hypoplasia, male 15.21 11.50 5 135965 18 34820943
Multiple organ dysfunction syndrome 15.19 11.50 208 135762 76358 34744603
Polydipsia psychogenic 15.14 11.50 8 135962 113 34820848
Poor quality sleep 15.14 11.50 68 135902 8188 34812773
Cytomegalovirus viraemia 15.13 11.50 5 135965 7425 34813536
Pulmonary thrombosis 15.06 11.50 5 135965 7402 34813559
Product administration error 15.01 11.50 112 135858 16232 34804729
Mixed delusion 15.01 11.50 6 135964 42 34820919
Myocardial ischaemia 14.99 11.50 28 135942 17380 34803581
Adverse drug reaction 14.93 11.50 61 135909 29281 34791680
Feminisation acquired 14.89 11.50 6 135964 43 34820918
Acute pulmonary oedema 14.85 11.50 5 135965 7338 34813623
Nephrotic syndrome 14.72 11.50 5 135965 7298 34813663
Eczema 14.72 11.50 31 135939 18405 34802556
Muscle contracture 14.67 11.50 21 135949 1223 34819738
Gender dysphoria 14.66 11.50 6 135964 45 34820916
Hyperreflexia 14.64 11.50 36 135934 3170 34817791
Electrocardiogram T wave abnormal 14.61 11.50 24 135946 1577 34819384
Hyperpyrexia 14.57 11.50 33 135937 2755 34818206
Screaming 14.57 11.50 23 135947 1461 34819500
Wound 14.56 11.50 22 135948 14842 34806119
Conductive deafness 14.53 11.50 11 135959 299 34820662
Illusion 14.52 11.50 17 135953 810 34820151
Haematoma 14.47 11.50 51 135919 25554 34795407
Hypovolaemia 14.46 11.50 9 135961 9225 34811736
Hip fracture 14.45 11.50 15 135955 11910 34809051
Aspiration 14.45 11.50 89 135881 12105 34808856
Gingival atrophy 14.43 11.50 6 135964 47 34820914
Skin disorder 14.34 11.50 19 135951 13536 34807425
Skin lesion 14.33 11.50 41 135929 21920 34799041
Cholangitis 14.27 11.50 8 135962 8681 34812280
Haematotoxicity 14.26 11.50 7 135963 8187 34812774
Neutropenia 14.26 11.50 746 135224 156032 34664929
Infertility male 14.24 11.50 9 135961 181 34820780
Frontotemporal dementia 14.17 11.50 10 135960 243 34820718
Hepatitis B 14.13 11.50 3 135967 5980 34814981
Mouth breathing 14.10 11.50 7 135963 86 34820875
Hyperdynamic left ventricle 14.06 11.50 9 135961 185 34820776
Renal cyst 14.05 11.50 9 135961 9084 34811877
Gallbladder disorder 14.05 11.50 4 135966 6538 34814423
Haemorrhagic stroke 14.04 11.50 4 135966 6535 34814426
Tympanic membrane disorder 14.01 11.50 6 135964 51 34820910
Suspected suicide attempt 13.99 11.50 8 135962 133 34820828
Compulsive shopping 13.97 11.50 12 135958 392 34820569
Intestinal perforation 13.96 11.50 9 135961 9051 34811910
Blood osmolarity increased 13.94 11.50 12 135958 393 34820568
Coprolalia 13.91 11.50 5 135965 25 34820936
Toxic epidermal necrolysis 13.90 11.50 137 135833 21509 34799452
Renal tubular acidosis 13.89 11.50 29 135941 2290 34818671
Oral mucosa erosion 13.87 11.50 18 135952 954 34820007
Blood urine present 13.86 11.50 13 135957 10821 34810140
Anuria 13.83 11.50 12 135958 10373 34810588
Gastric cancer 13.81 11.50 4 135966 6465 34814496
Clonus 13.76 11.50 32 135938 2718 34818243
Injection site pruritus 13.70 11.50 5 135965 6978 34813983
Spinal fracture 13.68 11.50 6 135964 7492 34813469
Acquired epileptic aphasia 13.66 11.50 3 135967 0 34820961
Dacryoadenitis acquired 13.66 11.50 3 135967 0 34820961
Deformity of orbit 13.66 11.50 3 135967 0 34820961
Congenital tongue anomaly 13.66 11.50 3 135967 0 34820961
Blindness congenital 13.66 11.50 3 135967 0 34820961
Renal fusion anomaly 13.66 11.50 3 135967 0 34820961
Hypocarnitinaemia 13.66 11.50 3 135967 0 34820961
Neonatal hypoacusis 13.66 11.50 3 135967 0 34820961
Agitation neonatal 13.66 11.50 19 135951 1077 34819884
Lacrimal gland enlargement 13.59 11.50 5 135965 27 34820934
Ischaemic cardiomyopathy 13.55 11.50 4 135966 6385 34814576
Miosis 13.53 11.50 73 135897 9462 34811499
Dysuria 13.47 11.50 57 135913 27095 34793866
CSF white blood cell count positive 13.44 11.50 5 135965 28 34820933
Gastritis 13.44 11.50 42 135928 21831 34799130
Hand-eye coordination impaired 13.43 11.50 6 135964 57 34820904
Mass 13.39 11.50 7 135963 7898 34813063
Progressive multifocal leukoencephalopathy 13.35 11.50 11 135959 9753 34811208
Dysphemia 13.34 11.50 23 135947 1572 34819389
Drug level fluctuating 13.32 11.50 13 135957 502 34820459
Sudden death 13.30 11.50 103 135867 15098 34805863
Vasoplegia syndrome 13.27 11.50 25 135945 1831 34819130
Use of accessory respiratory muscles 13.27 11.50 12 135958 420 34820541
Encephalitis autoimmune 13.23 11.50 15 135955 690 34820271
Joint range of motion decreased 13.11 11.50 6 135964 7306 34813655
Lordosis 13.07 11.50 11 135959 349 34820612
Feeding disorder 13.05 11.50 58 135912 6952 34814009
Swollen tongue 13.02 11.50 23 135947 14582 34806379
Burning sensation 13.02 11.50 33 135937 18361 34802600
Loss of consciousness 12.98 11.50 417 135553 82250 34738711
Blood uric acid increased 12.97 11.50 11 135959 9613 34811348
Acute respiratory failure 12.95 11.50 69 135901 30859 34790102
Dysphagia 12.94 11.50 326 135644 62055 34758906
Lip swelling 12.87 11.50 27 135943 16053 34804908
Hyperlactacidaemia 12.86 11.50 33 135937 2983 34817978
Oropharyngeal pain 12.82 11.50 83 135887 35402 34785559
Heparin-induced thrombocytopenia 12.82 11.50 3 135967 5592 34815369
Bulimia nervosa 12.75 11.50 5 135965 33 34820928
Major depression 12.75 11.50 43 135927 4529 34816432
Thrombocytopenia 12.73 11.50 736 135234 155511 34665450
Monorchidism 12.72 11.50 4 135966 12 34820949
Vitamin B6 decreased 12.72 11.50 4 135966 12 34820949
Locomotive syndrome 12.72 11.50 4 135966 12 34820949
Back disorder 12.65 11.50 5 135965 6646 34814315
Limb asymmetry 12.64 11.50 7 135963 109 34820852
Snoring 12.64 11.50 35 135935 3311 34817650
Disseminated intravascular coagulation 12.63 11.50 43 135927 21773 34799188
Wrong technique in product usage process 12.59 11.50 85 135885 35901 34785060
Haemorrhage intracranial 12.57 11.50 27 135943 15919 34805042
Adenoidal hypertrophy 12.56 11.50 8 135962 163 34820798
Therapeutic response changed 12.50 11.50 12 135958 454 34820507
Rales 12.47 11.50 12 135958 9871 34811090
Myopathy 12.42 11.50 16 135954 11538 34809423
Anticoagulation drug level decreased 12.37 11.50 7 135963 114 34820847
Insomnia 12.36 11.50 508 135462 103399 34717562
Lacrimation increased 12.30 11.50 9 135961 8473 34812488
Feeling of despair 12.27 11.50 17 135953 960 34820001
Reduced facial expression 12.25 11.50 18 135952 1073 34819888
Hypotony maculopathy 12.25 11.50 4 135966 14 34820947
Saccadic eye movement 12.23 11.50 8 135962 171 34820790
Organising pneumonia 12.22 11.50 4 135966 5975 34814986
Mastication disorder 12.19 11.50 20 135950 1313 34819648
Eye pruritus 12.15 11.50 7 135963 7482 34813479
Cytotoxic oedema 12.15 11.50 8 135962 173 34820788
Neutrophil count decreased 12.10 11.50 272 135698 50832 34770129
Cerebral cyst 12.08 11.50 10 135960 310 34820651
SJS-TEN overlap 12.08 11.50 10 135960 310 34820651
SARS-CoV-2 test positive 12.07 11.50 4 135966 5929 34815032
Anodontia 12.07 11.50 6 135964 74 34820887
Psychomotor disadaptation syndrome 12.07 11.50 6 135964 74 34820887
Pulmonary eosinophilia 12.03 11.50 9 135961 240 34820721
Necrotising enterocolitis neonatal 12.03 11.50 9 135961 240 34820721
Wrong schedule 12.03 11.50 8 135962 176 34820785
Drug-disease interaction 12.01 11.50 12 135958 477 34820484
Blood sodium increased 11.98 11.50 31 135939 2817 34818144
Spinal pain 11.93 11.50 4 135966 5885 34815076
Poisoning 11.93 11.50 85 135885 12141 34808820
Intervertebral disc degeneration 11.92 11.50 5 135965 6412 34814549
Therapeutic response shortened 11.90 11.50 7 135963 7397 34813564
Laryngitis 11.89 11.50 27 135943 2258 34818703
Benign prostatic hyperplasia 11.89 11.50 24 135946 14471 34806490
Post-anoxic myoclonus 11.84 11.50 4 135966 16 34820945
Cardiac murmur 11.80 11.50 61 135909 7776 34813185
Cardiovascular disorder 11.80 11.50 13 135957 10043 34810918
Poisoning deliberate 11.78 11.50 61 135909 7783 34813178
Adenocarcinoma of appendix 11.75 11.50 7 135963 126 34820835
Joint stiffness 11.75 11.50 15 135955 10858 34810103
Labelled drug-drug interaction issue 11.73 11.50 10 135960 323 34820638
Mitochondrial cytopathy 11.72 11.50 8 135962 184 34820777
Macrocephaly 11.62 11.50 12 135958 496 34820465
Nodule 11.61 11.50 6 135964 6813 34814148
Hirsutism 11.61 11.50 8 135962 187 34820774
Near drowning 11.59 11.50 3 135967 3 34820958
Delusional disorder, mixed type 11.59 11.50 3 135967 3 34820958
Ornithine transcarbamoylase deficiency 11.59 11.50 3 135967 3 34820958
Kluver-Bucy syndrome 11.59 11.50 3 135967 3 34820958
CSF glucose increased 11.59 11.50 3 135967 3 34820958
Nasopharyngeal reflux 11.59 11.50 3 135967 3 34820958
Pulmonary valve incompetence 11.56 11.50 16 135954 903 34820058
Anticholinergic syndrome 11.55 11.50 19 135951 1250 34819711
Acute graft versus host disease in skin 11.51 11.50 3 135967 5198 34815763

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2628.85 10.63 2801 200278 186033 79355276
Hyperammonaemia 2448.15 10.63 958 202121 10135 79531174
Drug interaction 2378.27 10.63 3983 199096 411200 79130109
Hyperammonaemic encephalopathy 1908.73 10.63 640 202439 4142 79537167
Status epilepticus 1453.18 10.63 864 202215 24177 79517132
Aggression 1298.18 10.63 1060 202019 49898 79491411
Somnolence 1208.54 10.63 2174 200905 236807 79304502
Neuroleptic malignant syndrome 1189.15 10.63 788 202291 26771 79514538
Sopor 1058.53 10.63 787 202292 32223 79509086
Epilepsy 959.55 10.63 811 202268 40049 79501260
Psychotic disorder 933.93 10.63 803 202276 40599 79500710
Generalised tonic-clonic seizure 828.59 10.63 770 202309 43140 79498169
Extrapyramidal disorder 795.67 10.63 571 202508 22108 79519201
Multiple-drug resistance 789.64 10.63 405 202674 8403 79532906
Toxicity to various agents 757.90 10.63 2576 200503 418964 79122345
Mania 732.20 10.63 499 202580 17761 79523548
Arthralgia 722.92 10.63 277 202802 571526 78969783
Ammonia increased 710.42 10.63 360 202719 7275 79534034
Granulocytopenia 696.01 10.63 407 202672 11024 79530285
Agitation 678.92 10.63 1038 202041 98677 79442632
Coma 668.81 10.63 1036 202043 99613 79441696
Parkinsonism 643.19 10.63 444 202635 16140 79525169
Intentional overdose 631.71 10.63 1038 202041 104922 79436387
Pain 591.67 10.63 554 202525 703248 78838061
Dyspnoea 586.39 10.63 798 202281 856227 78685082
Overdose 584.54 10.63 1384 201695 182822 79358487
Petit mal epilepsy 562.11 10.63 280 202799 5447 79535862
Sedation 561.89 10.63 677 202402 51218 79490091
Abnormal behaviour 541.98 10.63 561 202518 35860 79505449
Intentional self-injury 518.15 10.63 519 202560 31900 79509409
Tremor 505.34 10.63 1246 201833 168837 79372472
Joint swelling 492.26 10.63 74 203005 288572 79252737
Drug level increased 492.25 10.63 555 202524 39096 79502213
Ataxia 491.50 10.63 449 202630 24590 79516719
Salivary hypersecretion 471.29 10.63 346 202733 13878 79527431
Depressed level of consciousness 465.48 10.63 862 202217 95790 79445519
Diarrhoea 460.12 10.63 974 202105 879515 78661794
Rheumatoid arthritis 456.04 10.63 17 203062 208453 79332856
Drug reaction with eosinophilia and systemic symptoms 444.48 10.63 674 202405 63570 79477739
Irritability 427.89 10.63 526 202553 40618 79500691
Suicide attempt 420.02 10.63 756 202323 82176 79459133
Infusion related reaction 416.42 10.63 49 203030 230188 79311121
Fatigue 409.37 10.63 1125 201954 928602 78612707
Schizophrenia 390.42 10.63 320 202759 15120 79526189
Antipsychotic drug level increased 388.98 10.63 222 202857 5735 79535574
Anticonvulsant drug level increased 388.36 10.63 171 202908 2482 79538827
Delusion 373.33 10.63 352 202727 20071 79521238
Synovitis 366.67 10.63 3 203076 150731 79390578
Arthropathy 360.04 10.63 23 203056 177088 79364221
Peripheral swelling 359.84 10.63 119 202960 269498 79271811
Encephalopathy 358.77 10.63 628 202451 66769 79474540
Cognitive disorder 353.49 10.63 637 202442 69289 79472020
Catatonia 350.31 10.63 239 202840 8517 79532792
Altered state of consciousness 348.39 10.63 491 202588 43331 79497978
Psychomotor hyperactivity 340.19 10.63 307 202772 16542 79524767
Foetal anticonvulsant syndrome 339.34 10.63 86 202993 156 79541153
Blood creatine phosphokinase increased 337.84 10.63 605 202474 65485 79475824
Drug abuse 336.15 10.63 1044 202035 161647 79379662
Partial seizures 330.88 10.63 233 202846 8745 79532564
Nausea 328.04 10.63 1293 201786 955903 78585406
Hallucination, auditory 324.62 10.63 328 202751 20365 79520944
Fanconi syndrome 317.36 10.63 152 202927 2704 79538605
Psychomotor skills impaired 309.68 10.63 183 202896 5054 79536255
Pain in extremity 308.99 10.63 284 202795 364254 79177055
Suicidal ideation 307.96 10.63 632 202447 75708 79465601
Drug level decreased 303.81 10.63 269 202810 14133 79527176
Muscle rigidity 302.51 10.63 310 202769 19572 79521737
Anticonvulsant drug level decreased 300.48 10.63 130 202949 1804 79539505
Febrile neutropenia 297.77 10.63 108 202971 230891 79310418
Treatment noncompliance 295.17 10.63 500 202579 51768 79489541
Myoclonic epilepsy 291.68 10.63 128 202951 1842 79539467
Electroencephalogram abnormal 290.58 10.63 178 202901 5256 79536053
Sinusitis 277.58 10.63 77 203002 195424 79345885
Hypernatraemia 277.47 10.63 256 202823 14195 79527114
Depression 276.25 10.63 1189 201890 215601 79325708
Pneumonia aspiration 275.55 10.63 559 202520 66408 79474901
Swelling 274.81 10.63 104 202975 216607 79324702
Paranoia 272.40 10.63 290 202789 19142 79522167
Tardive dyskinesia 271.28 10.63 221 202858 10350 79530959
Abdominal discomfort 270.37 10.63 151 202928 250576 79290733
Dysmorphism 268.95 10.63 87 202992 494 79540815
Anticonvulsant drug level above therapeutic 264.84 10.63 103 202976 1068 79540241
Nasopharyngitis 262.29 10.63 161 202918 253720 79287589
Disorientation 260.64 10.63 526 202553 62250 79479059
Delirium 257.45 10.63 626 202453 84001 79457308
Drug ineffective 256.41 10.63 4013 199066 1076900 78464409
Hypersensitivity 256.39 10.63 177 202902 262062 79279247
Hypothermia 254.76 10.63 302 202777 22444 79518865
Sudden unexplained death in epilepsy 249.18 10.63 85 202994 583 79540726
Psychomotor retardation 245.50 10.63 168 202911 6016 79535293
Intellectual disability 242.66 10.63 100 202979 1220 79540089
Completed suicide 240.13 10.63 1248 201831 244519 79296790
Headache 230.52 10.63 872 202207 652900 78888409
Akathisia 229.93 10.63 222 202857 13037 79528272
Cough 229.74 10.63 362 202717 366427 79174882
Hypomania 224.29 10.63 172 202907 7372 79533937
Pruritus 220.29 10.63 419 202660 394229 79147080
Drug withdrawal convulsions 219.22 10.63 109 202970 2111 79539198
Myocarditis 218.14 10.63 273 202806 21460 79519849
Bradyphrenia 217.02 10.63 195 202884 10445 79530864
Dystonia 216.69 10.63 270 202809 21129 79520180
Myoclonus 215.51 10.63 307 202772 27353 79513956
Dysarthria 214.03 10.63 508 202571 67114 79474195
Disturbance in attention 213.67 10.63 428 202651 50373 79490936
Mental disorder 210.20 10.63 324 202755 30978 79510331
Foetal exposure during pregnancy 208.12 10.63 148 202931 5642 79535667
Stevens-Johnson syndrome 204.55 10.63 362 202717 38804 79502505
Dyskinesia 203.82 10.63 390 202689 44383 79496926
Anticonvulsant drug level below therapeutic 202.48 10.63 83 202996 998 79540311
Drug resistance 201.21 10.63 375 202704 41838 79499471
Systemic lupus erythematosus 199.72 10.63 34 203045 121115 79420194
Drug intolerance 195.21 10.63 231 202848 263888 79277421
Psychiatric decompensation 194.68 10.63 123 202956 3840 79537469
Bipolar disorder 191.21 10.63 158 202921 7549 79533760
Mental impairment 190.86 10.63 239 202840 18797 79522512
Back pain 188.71 10.63 302 202777 303878 79237431
Speech disorder 186.55 10.63 422 202657 54023 79487286
Drug ineffective for unapproved indication 185.52 10.63 406 202673 50832 79490477
Glossodynia 184.25 10.63 23 203056 103314 79437995
Toxic encephalopathy 182.47 10.63 183 202896 11257 79530052
Anaemia 181.46 10.63 557 202522 444458 79096851
Contraindicated product administered 181.45 10.63 87 202992 157451 79383858
Hepatic function abnormal 181.37 10.63 501 202578 72606 79468703
Wrong patient received product 179.88 10.63 124 202955 4494 79536815
Chest pain 179.18 10.63 276 202803 282028 79259281
Behaviour disorder 179.11 10.63 140 202939 6173 79535136
Developmental delay 179.07 10.63 79 203000 1152 79540157
Restlessness 177.04 10.63 376 202703 46116 79495193
Psychogenic seizure 173.66 10.63 89 202990 1842 79539467
Arthritis 173.12 10.63 40 203039 114840 79426469
Cardiac failure congestive 172.84 10.63 73 203006 142329 79398980
Nystagmus 170.18 10.63 165 202914 9739 79531570
Abdominal pain upper 169.42 10.63 192 202887 223627 79317682
Focal dyscognitive seizures 167.53 10.63 107 202972 3405 79537904
Discomfort 164.75 10.63 57 203022 125560 79415749
Leukopenia 164.69 10.63 660 202419 115853 79425456
Neuropathy peripheral 164.32 10.63 77 203002 141228 79400081
Paradoxical drug reaction 163.22 10.63 140 202939 7045 79534264
Stupor 162.45 10.63 137 202942 6735 79534574
Schizoaffective disorder 161.80 10.63 88 202991 2064 79539245
Electrocardiogram QT prolonged 155.17 10.63 545 202534 89841 79451468
Confusional state 152.52 10.63 1354 201725 316643 79224666
Thrombocytopenia 151.00 10.63 1174 201905 264085 79277224
Duodenal ulcer perforation 149.72 10.63 4 203075 66207 79475102
Rhabdomyolysis 149.61 10.63 589 202490 102542 79438767
Tonic convulsion 148.35 10.63 84 202995 2136 79539173
Persecutory delusion 148.30 10.63 113 202966 4796 79536513
Depressive symptom 147.63 10.63 126 202953 6297 79535012
Cerebral atrophy 145.31 10.63 138 202941 7937 79533372
Speech disorder developmental 143.57 10.63 57 203022 627 79540682
Mental status changes 143.07 10.63 435 202644 66524 79474785
Autism spectrum disorder 142.43 10.63 66 203013 1086 79540223
Atrial fibrillation 142.01 10.63 177 202902 197709 79343600
Oculogyric crisis 140.97 10.63 90 202989 2862 79538447
Priapism 138.96 10.63 105 202974 4400 79536909
Helicobacter infection 138.82 10.63 10 203069 69694 79471615
Brain oedema 137.75 10.63 238 202841 25025 79516284
Injection site pain 135.87 10.63 81 202998 129757 79411552
Urticaria 135.69 10.63 163 202916 185038 79356271
Impaired healing 135.13 10.63 29 203050 87626 79453683
Wound 132.49 10.63 65 203014 116114 79425195
Osteoarthritis 132.34 10.63 30 203049 87279 79454030
Hypoaesthesia 132.31 10.63 157 202922 179195 79362114
Eosinophilia 131.05 10.63 329 202750 45016 79496293
Stomatitis 130.60 10.63 109 202970 146648 79394661
Eosinophilic pleural effusion 129.84 10.63 44 203035 295 79541014
Myocardial infarction 129.72 10.63 167 202912 183962 79357347
Malignant neoplasm progression 128.59 10.63 95 202984 135895 79405414
Lethargy 128.35 10.63 477 202602 80815 79460494
Gastrointestinal haemorrhage 126.25 10.63 114 202965 147605 79393704
Blood pressure increased 125.29 10.63 216 202863 211144 79330165
Herpes zoster 124.20 10.63 41 203038 93042 79448267
Disease progression 124.00 10.63 173 202906 184189 79357120
Psoriatic arthropathy 123.99 10.63 24 203055 77975 79463334
Abdominal pain 123.53 10.63 541 202538 389028 79152281
Antipsychotic drug level below therapeutic 122.88 10.63 61 203018 1177 79540132
Therapeutic product effect decreased 121.34 10.63 143 202936 163720 79377589
Antipsychotic drug level above therapeutic 121.19 10.63 72 203007 2008 79539301
Pancreatitis acute 121.10 10.63 338 202741 49266 79492043
Bipolar I disorder 119.64 10.63 72 203007 2057 79539252
Euphoric mood 118.49 10.63 121 202958 7605 79533704
Alopecia 118.40 10.63 258 202821 231097 79310212
Learning disorder 117.19 10.63 47 203032 532 79540777
Acute kidney injury 117.13 10.63 808 202271 518596 79022713
Psychiatric symptom 116.75 10.63 115 202964 6920 79534389
Atonic seizures 116.70 10.63 51 203028 726 79540583
Asterixis 115.72 10.63 77 203002 2630 79538679
COVID-19 115.25 10.63 139 202940 157535 79383774
Neutrophil count increased 113.37 10.63 239 202840 29157 79512152
Blood prolactin increased 111.74 10.63 88 202991 3923 79537386
Asthenia 111.46 10.63 804 202275 510885 79030424
Hyperprolactinaemia 110.08 10.63 93 202986 4583 79536726
Interstitial lung disease 109.94 10.63 76 203003 112524 79428785
Carnitine deficiency 109.70 10.63 37 203042 244 79541065
Metabolic acidosis 109.08 10.63 458 202621 82071 79459238
Hypotonia 107.92 10.63 148 202931 12722 79528587
Seizure cluster 107.64 10.63 40 203039 362 79540947
Folliculitis 107.31 10.63 9 203070 55371 79485938
Product substitution issue 106.76 10.63 188 202891 20068 79521241
Dyspnoea exertional 106.66 10.63 44 203035 87029 79454280
Pleurothotonus 106.19 10.63 71 203008 2445 79538864
Affect lability 105.98 10.63 137 202942 11122 79530187
Fluid retention 105.78 10.63 24 203055 69785 79471524
Thrombosis 105.46 10.63 41 203038 84059 79457250
Drug level below therapeutic 104.93 10.63 127 202952 9643 79531666
Malaise 104.13 10.63 775 202304 489094 79052215
Impulsive behaviour 103.94 10.63 74 203005 2826 79538483
Gaze palsy 103.85 10.63 75 203004 2930 79538379
Musculoskeletal pain 102.73 10.63 67 203012 102287 79439022
Rash 102.61 10.63 960 202119 577398 78963911
Bradykinesia 102.20 10.63 114 202965 7929 79533380
Influenza 101.53 10.63 108 202971 129498 79411811
White blood cell count increased 100.84 10.63 417 202662 74216 79467093
Antipsychotic drug level decreased 100.29 10.63 53 203026 1171 79540138
Injection site erythema 99.93 10.63 37 203042 78160 79463149
Hypertonia 99.71 10.63 107 202972 7125 79534184
Plasma cell myeloma 99.60 10.63 10 203069 53249 79488060
Loss of consciousness 99.20 10.63 750 202329 167193 79374116
Myalgia 99.18 10.63 202 202877 185439 79355870
Dysphoria 99.00 10.63 88 202991 4646 79536663
Drug hypersensitivity 98.46 10.63 409 202670 298507 79242802
Thinking abnormal 98.01 10.63 143 202936 13018 79528291
Neutropenia 97.94 10.63 1142 201937 286568 79254741
Cerebellar atrophy 97.20 10.63 51 203028 1110 79540199
Inflammation 95.97 10.63 60 203019 93693 79447616
Chest discomfort 95.37 10.63 127 202952 137917 79403392
Acidosis hyperchloraemic 94.12 10.63 45 203034 797 79540512
Anger 91.37 10.63 160 202919 17002 79524307
Obsessive-compulsive disorder 91.21 10.63 93 202986 5834 79535475
Propofol infusion syndrome 91.09 10.63 59 203020 1924 79539385
Acute hepatic failure 90.71 10.63 222 202857 29891 79511418
C-reactive protein abnormal 90.66 10.63 9 203070 48358 79492951
Mucosal inflammation 89.69 10.63 40 203039 75540 79465769
Contusion 89.10 10.63 151 202928 148625 79392684
Inappropriate antidiuretic hormone secretion 89.06 10.63 203 202876 26110 79515199
Respiratory depression 88.94 10.63 209 202870 27421 79513888
Product residue present 88.78 10.63 73 203006 3463 79537846
Paraesthesia 88.24 10.63 199 202880 176124 79365185
Death 88.19 10.63 970 202109 565544 78975765
Infection 87.08 10.63 319 202760 241393 79299916
Intentional product use issue 86.91 10.63 159 202920 151953 79389356
Knee arthroplasty 86.70 10.63 6 203073 43242 79498067
Hyperlactacidaemia 86.48 10.63 88 202991 5507 79535802
Bronchitis 86.43 10.63 124 202955 130520 79410789
Differential white blood cell count abnormal 86.19 10.63 58 203021 2019 79539290
Irritable bowel syndrome 85.55 10.63 26 203053 62215 79479094
Haematochezia 84.44 10.63 60 203019 87585 79453724
Psychotic symptom 83.50 10.63 63 203016 2634 79538675
Communication disorder 83.49 10.63 75 203004 4015 79537294
Rhinorrhoea 83.10 10.63 45 203034 76029 79465280
Muscle spasms 82.80 10.63 203 202876 174527 79366782
Coordination abnormal 82.74 10.63 154 202925 17158 79524151
Chills 82.51 10.63 178 202901 160056 79381253
Oppositional defiant disorder 82.46 10.63 35 203044 462 79540847
Hyponatraemia 81.92 10.63 751 202328 177097 79364212
Toxic epidermal necrolysis 81.00 10.63 274 202805 44307 79497002
Drooling 80.41 10.63 87 202992 5847 79535462
General physical health deterioration 80.20 10.63 394 202685 274844 79266465
Poisoning 80.08 10.63 190 202889 25082 79516227
Fibromyalgia 79.63 10.63 32 203047 64308 79477001
Hyperthermia 79.48 10.63 155 202924 17882 79523427
Muscle injury 79.20 10.63 14 203065 48547 79492762
Disinhibition 78.91 10.63 60 203019 2538 79538771
Gastrointestinal disorder 78.87 10.63 118 202961 122087 79419222
Infantile spasms 78.38 10.63 29 203050 259 79541050
Dysmetria 78.32 10.63 43 203036 1028 79540281
Hallucination, visual 77.90 10.63 221 202858 32508 79508801
Psoriasis 77.90 10.63 68 203011 89519 79451790
Epistaxis 77.63 10.63 102 202977 111413 79429896
Depression suicidal 77.53 10.63 70 203009 3772 79537537
Unresponsive to stimuli 77.17 10.63 314 202765 55474 79485835
Pancreatitis 76.60 10.63 362 202717 68213 79473096
Retinogram abnormal 76.13 10.63 30 203049 323 79540986
Tachycardia 76.06 10.63 739 202340 177029 79364280
Cogwheel rigidity 75.97 10.63 63 203016 3025 79538284
Pericarditis 74.98 10.63 93 202986 104143 79437166
Necrosis ischaemic 74.88 10.63 42 203037 1048 79540261
Enuresis 74.42 10.63 63 203016 3113 79538196
Hallucination 73.84 10.63 421 202658 85324 79455985
Homicidal ideation 73.76 10.63 65 203014 3392 79537917
Logorrhoea 73.64 10.63 72 203007 4293 79537016
Pneumonia 73.52 10.63 1211 201868 659035 78882274
Blood lactic acid increased 73.35 10.63 123 202956 12621 79528688
Gingival hypertrophy 72.95 10.63 62 203017 3080 79538229
Pressure of speech 72.84 10.63 43 203036 1185 79540124
Blood pressure systolic increased 72.62 10.63 40 203039 66946 79474363
Serotonin syndrome 72.55 10.63 266 202813 44761 79496548
Cardiac failure 72.50 10.63 181 202898 154661 79386648
Anaphylactic reaction 72.28 10.63 64 203015 83679 79457630
Cytokine release syndrome 72.15 10.63 5 203074 35993 79505316
Erythema 71.96 10.63 308 202771 222982 79318327
Hot flush 71.76 10.63 25 203054 54852 79486457
Chorea 71.61 10.63 55 203024 2362 79538947
Injection site reaction 71.57 10.63 25 203054 54760 79486549
Mitochondrial DNA mutation 70.21 10.63 30 203049 403 79540906
Flushing 69.74 10.63 73 203006 88195 79453114
Resting tremor 69.24 10.63 45 203034 1476 79539833
Apathy 69.11 10.63 121 202958 12856 79528453
Dry skin 68.92 10.63 44 203035 67951 79473358
Tearfulness 68.90 10.63 81 202998 5964 79535345
Autonomic nervous system imbalance 68.27 10.63 71 203008 4559 79536750
Drug withdrawal syndrome 68.10 10.63 219 202860 34499 79506810
Hyperkinesia 67.81 10.63 56 203023 2673 79538636
Encephalitis autoimmune 67.53 10.63 52 203027 2242 79539067
Carnitine decreased 66.95 10.63 14 203065 3 79541306
Mobility decreased 66.90 10.63 131 202948 122044 79419265
Decreased eye contact 66.78 10.63 36 203043 829 79540480
Night sweats 65.97 10.63 25 203054 52070 79489239
Gait disturbance 65.88 10.63 813 202266 206693 79334616
Posture abnormal 65.65 10.63 64 203015 3802 79537507
Renal failure 65.49 10.63 276 202803 200692 79340617
Urinary incontinence 65.35 10.63 241 202838 40668 79500641
Partial seizures with secondary generalisation 64.86 10.63 32 203047 609 79540700
Grandiosity 64.49 10.63 31 203048 556 79540753
Tonic clonic movements 63.78 10.63 50 203029 2214 79539095
Injection site pruritus 63.13 10.63 15 203064 42268 79499041
Mood altered 62.98 10.63 140 202939 17707 79523602
Feeling hot 62.84 10.63 37 203042 59697 79481612
Cerebrovascular accident 62.69 10.63 195 202884 155097 79386212
Attention deficit hyperactivity disorder 62.32 10.63 58 203021 3251 79538058
Drug level changed 62.06 10.63 30 203049 545 79540764
Nasal congestion 61.97 10.63 62 203017 76490 79464819
Neoplasm progression 61.87 10.63 27 203052 51655 79489654
Delusion of grandeur 61.86 10.63 41 203038 1391 79539918
Ascites 61.39 10.63 61 203018 75501 79465808
Craniosynostosis 61.38 10.63 18 203061 69 79541240
Depressed mood 60.92 10.63 265 202814 48215 79493094
Hypertension 60.91 10.63 544 202535 330448 79210861
Blood pressure fluctuation 60.79 10.63 49 203030 67096 79474213
Product dose omission issue 60.77 10.63 375 202704 247162 79294147
Injection site swelling 60.72 10.63 22 203057 47110 79494199
Hallucinations, mixed 60.37 10.63 81 202998 6818 79534491
Increased appetite 60.33 10.63 109 202970 11869 79529440
Prostate cancer 60.28 10.63 7 203072 33261 79508048
Weight decreased 60.14 10.63 596 202483 354602 79186707
Oropharyngeal pain 60.09 10.63 117 202962 109236 79432073
Pulmonary fibrosis 59.59 10.63 19 203060 44093 79497216
Oedema peripheral 59.47 10.63 387 202692 251901 79289408
Bone pain 59.39 10.63 34 203045 55708 79485601
Heart rate decreased 59.18 10.63 55 203024 70261 79471048
Choreoathetosis 58.44 10.63 41 203038 1529 79539780
Throat irritation 58.30 10.63 16 203063 40930 79500379
Language disorder 57.97 10.63 55 203024 3159 79538150
Dysgeusia 57.95 10.63 37 203042 57140 79484169
Joint range of motion decreased 57.89 10.63 8 203071 33274 79508035
Metabolic encephalopathy 57.68 10.63 92 202987 9055 79532254
Urinary tract infection 57.41 10.63 436 202643 274076 79267233
Mydriasis 57.38 10.63 134 202945 17509 79523800
Brugada syndrome 57.27 10.63 37 203042 1201 79540108
Intestinal ischaemia 57.21 10.63 113 202966 13157 79528152
Bursitis 57.02 10.63 11 203068 35833 79505476
Postictal psychosis 56.75 10.63 20 203059 153 79541156
Learning disability 56.61 10.63 21 203058 189 79541120
Diabetes insipidus 56.12 10.63 68 203011 5169 79536140
Hypospadias 56.12 10.63 19 203060 127 79541182
Ill-defined disorder 56.07 10.63 51 203028 65824 79475485
Lower respiratory tract infection 55.96 10.63 157 202922 129063 79412246
Haemoptysis 55.72 10.63 37 203042 55962 79485347
Leukocytosis 54.96 10.63 238 202841 43217 79498092
Musculoskeletal stiffness 54.79 10.63 244 202835 174764 79366545
Hip arthroplasty 54.75 10.63 12 203067 35744 79505565
Congenital hand malformation 54.73 10.63 11 203068 0 79541309
Lung disorder 54.72 10.63 75 203004 80482 79460827
Neovascularisation 54.64 10.63 36 203043 1209 79540100
Hyperosmolar state 54.34 10.63 29 203050 654 79540655
Intra-abdominal pressure increased 54.16 10.63 22 203057 258 79541051
Rectal haemorrhage 53.91 10.63 69 203010 76231 79465078
Hirsutism 53.57 10.63 37 203042 1345 79539964
Nephrogenic diabetes insipidus 53.46 10.63 44 203035 2090 79539219
Judgement impaired 53.22 10.63 36 203043 1264 79540045
Pneumonitis 53.14 10.63 46 203033 60814 79480495
Acute myocardial infarction 53.06 10.63 71 203008 76965 79464344
Physical assault 52.93 10.63 39 203040 1572 79539737
Agranulocytosis 52.70 10.63 241 202838 44789 79496520
Hypokinesia 52.68 10.63 136 202943 18924 79522385
Basal cell carcinoma 52.48 10.63 15 203064 37360 79503949
Drop attacks 52.46 10.63 33 203046 1022 79540287
Pain in jaw 52.33 10.63 26 203053 46125 79495184
Obesity 52.03 10.63 202 202877 34923 79506386
Coronary artery disease 51.89 10.63 54 203025 65420 79475889
Erectile dysfunction 51.71 10.63 115 202964 14549 79526760
Postictal state 51.67 10.63 41 203038 1848 79539461
Sexually inappropriate behaviour 51.58 10.63 26 203053 519 79540790
Pulmonary arterial hypertension 51.32 10.63 6 203073 28360 79512949
Renal tubular acidosis 50.76 10.63 54 203025 3560 79537749
Flight of ideas 50.65 10.63 30 203049 832 79540477
Cataract 50.63 10.63 50 203029 62070 79479239
Diverticulitis 50.42 10.63 27 203052 45909 79495400
Conjunctival hyperaemia 50.08 10.63 59 203020 4354 79536955
Injection site bruising 49.75 10.63 21 203058 40981 79500328
Change in seizure presentation 49.69 10.63 25 203054 497 79540812
Osteonecrosis of jaw 49.54 10.63 24 203055 43202 79498107
Sluggishness 48.35 10.63 71 203008 6501 79534808
Pneumocystis jirovecii pneumonia 47.62 10.63 12 203067 32496 79508813
Affective disorder 47.49 10.63 80 202999 8239 79533070
Automatism 47.49 10.63 18 203061 173 79541136
Mutism 47.44 10.63 43 203036 2329 79538980
Staring 47.20 10.63 45 203034 2600 79538709
Dizziness 47.20 10.63 1002 202077 525439 79015870
Hyperglycinaemia 47.14 10.63 10 203069 3 79541306
Palpitations 46.95 10.63 165 202914 126445 79414864
Dehydration 46.92 10.63 405 202674 247782 79293527
Manic symptom 45.91 10.63 16 203063 118 79541191
Educational problem 45.90 10.63 22 203057 392 79540917
Upper gastrointestinal haemorrhage 45.89 10.63 24 203055 41356 79499953
Head titubation 45.79 10.63 29 203050 909 79540400
Angiofibroma 45.67 10.63 16 203063 120 79541189
Oedema 45.58 10.63 154 202925 119426 79421883
Negativism 45.45 10.63 28 203051 835 79540474
Palmar-plantar erythrodysaesthesia syndrome 45.24 10.63 14 203065 33120 79508189
Hyperkalaemia 45.21 10.63 145 202934 114253 79427056
Asthma 44.95 10.63 184 202895 134911 79406398
Joint stiffness 44.81 10.63 24 203055 40806 79500503
Aphasia 44.62 10.63 236 202843 46496 79494813
Withdrawal syndrome 44.41 10.63 160 202919 26694 79514615
Refusal of treatment by patient 44.25 10.63 81 202998 8910 79532399
Homicide 44.21 10.63 31 203048 1155 79540154
Self-injurious ideation 43.56 10.63 50 203029 3588 79537721
Drug level above therapeutic 43.45 10.63 79 203000 8644 79532665
Melaena 43.08 10.63 55 203024 60835 79480474
Suicidal behaviour 42.94 10.63 47 203032 3200 79538109
Delusional disorder, unspecified type 42.79 10.63 26 203053 756 79540553
Anticonvulsant drug level abnormal 42.76 10.63 13 203066 58 79541251
Hypervolaemia 42.75 10.63 28 203051 42662 79498647
Bruxism 42.69 10.63 52 203027 3974 79537335
Dysgraphia 42.63 10.63 52 203027 3980 79537329
Dementia 42.56 10.63 149 202930 24510 79516799
Excessive eye blinking 42.46 10.63 35 203044 1666 79539643
Food interaction 42.44 10.63 35 203044 1667 79539642
Pulmonary hypertension 42.39 10.63 36 203043 48044 79493265
Oral mucosa erosion 42.33 10.63 37 203042 1910 79539399
Acute myeloid leukaemia 42.26 10.63 13 203066 30872 79510437
Metastases to bone 42.18 10.63 6 203073 24421 79516888
Pulmonary mass 41.99 10.63 11 203068 29023 79512286
Weight increased 41.97 10.63 963 202116 276423 79264886
Rash maculo-papular 41.67 10.63 265 202814 55813 79485496
Prescribed overdose 41.58 10.63 199 202880 37684 79503625
Postictal paralysis 41.54 10.63 20 203059 360 79540949
Flatulence 41.47 10.63 29 203050 42695 79498614
Skin ulcer 41.42 10.63 46 203033 54104 79487205
Wheezing 41.30 10.63 155 202924 116509 79424800
Coma scale abnormal 41.22 10.63 77 203002 8601 79532708
Pulmonary embolism 41.10 10.63 262 202817 171392 79369917
Miosis 40.92 10.63 110 202969 15679 79525630
Soliloquy 40.83 10.63 24 203055 656 79540653
Sepsis 40.74 10.63 464 202615 268964 79272345
Perseveration 40.71 10.63 20 203059 377 79540932
Metastases to liver 40.43 10.63 11 203068 28303 79513006
Cryptorchism 40.34 10.63 11 203068 30 79541279
Schizoaffective disorder bipolar type 40.01 10.63 17 203062 225 79541084
Localised infection 39.91 10.63 23 203056 37552 79503757
Social avoidant behaviour 39.82 10.63 55 203024 4759 79536550
Mood swings 39.53 10.63 126 202953 19754 79521555
Acute coronary syndrome 39.43 10.63 4 203075 21129 79520180
Product use in unapproved indication 39.38 10.63 874 202205 249485 79291824
Confabulation 39.21 10.63 21 203058 477 79540832
Porphyria acute 39.19 10.63 32 203047 1503 79539806
Cytomegalovirus infection 38.75 10.63 31 203048 42613 79498696
Hypersexuality 38.70 10.63 33 203046 1647 79539662
Metabolic syndrome 38.59 10.63 41 203038 2699 79538610
Intentional product misuse 38.43 10.63 391 202688 94774 79446535
Illness 38.41 10.63 37 203042 46474 79494835
Bladder cancer 38.31 10.63 3 203076 19523 79521786
Convulsive threshold lowered 38.24 10.63 26 203053 921 79540388
Lennox-Gastaut syndrome 38.05 10.63 16 203063 206 79541103
Bacteraemia 37.96 10.63 18 203061 32806 79508503
Cellulitis 37.89 10.63 146 202933 108914 79432395
Maternal exposure during pregnancy 37.71 10.63 199 202880 136339 79404970
Incoherent 37.48 10.63 69 203010 7623 79533686
Aspergillus infection 37.43 10.63 3 203076 19158 79522151
Tic 37.38 10.63 42 203037 2944 79538365
Angina pectoris 37.36 10.63 46 203033 51686 79489623
Microcephaly 37.30 10.63 15 203064 171 79541138
Bronchopulmonary aspergillosis 37.30 10.63 6 203073 22288 79519021
Total lung capacity increased 37.09 10.63 37 203042 2261 79539048
Inappropriate affect 37.09 10.63 31 203048 1505 79539804
Polydipsia 37.02 10.63 63 203016 6542 79534767
Cystitis 36.93 10.63 48 203031 52684 79488625
Dyspepsia 36.80 10.63 147 202932 108540 79432769
Tumour lysis syndrome 36.72 10.63 8 203071 23931 79517378
Sinus congestion 36.52 10.63 4 203075 19892 79521417
Hepatic failure 36.46 10.63 274 202805 60938 79480371
Breast hyperplasia 36.44 10.63 14 203065 140 79541169
Tachyphrenia 36.39 10.63 35 203044 2045 79539264
Borderline personality disorder 36.36 10.63 25 203054 902 79540407
Red blood cell sedimentation rate increased 36.28 10.63 38 203041 45904 79495405
Poisoning deliberate 36.23 10.63 118 202961 18710 79522599
Anxiety 36.12 10.63 858 202221 247654 79293655
Platelet count decreased 35.99 10.63 696 202383 193968 79347341
Fungal infection 35.91 10.63 32 203047 41716 79499593
Ileus paralytic 35.69 10.63 77 203002 9543 79531766
Echolalia 35.50 10.63 18 203061 364 79540945
Transfusion 35.11 10.63 6 203073 21324 79519985
Transaminases increased 35.10 10.63 239 202840 51504 79489805
Normal pressure hydrocephalus 34.82 10.63 20 203059 523 79540786
Saccadic eye movement 34.79 10.63 14 203065 160 79541149
Intensive care unit acquired weakness 34.71 10.63 33 203046 1900 79539409
Tendonitis 34.52 10.63 9 203070 23821 79517488
Hepatic adenoma 34.48 10.63 17 203062 323 79540986
Pancreatitis necrotising 34.37 10.63 46 203033 3862 79537447
Medication overuse headache 34.37 10.63 24 203055 888 79540421
Verbal abuse 34.16 10.63 16 203063 270 79541039
Gastrooesophageal reflux disease 34.04 10.63 143 202936 104103 79437206
Akinesia 33.86 10.63 42 203037 3270 79538039
Ulcer 33.81 10.63 17 203062 29955 79511354
Motor developmental delay 33.80 10.63 15 203064 222 79541087
Apraxia 33.65 10.63 39 203040 2828 79538481
Sneezing 33.61 10.63 5 203074 19678 79521631
Stereotypy 33.60 10.63 24 203055 921 79540388
Magnetic resonance imaging head abnormal 33.54 10.63 38 203041 2688 79538621
Device expulsion 33.43 10.63 12 203067 25849 79515460
Brief psychotic disorder, with postpartum onset 33.42 10.63 9 203070 23 79541286
Oligoasthenozoospermia 33.34 10.63 8 203071 10 79541299
Paraesthesia oral 33.17 10.63 6 203073 20465 79520844
Poverty of speech 33.15 10.63 20 203059 574 79540735
Gastric disorder 33.04 10.63 28 203051 37405 79503904
Cerebellar syndrome 33.03 10.63 54 203025 5426 79535883
Limbic encephalitis 32.92 10.63 23 203056 852 79540457
Angiomyolipoma 32.77 10.63 14 203065 188 79541121
Breast cancer 32.70 10.63 23 203056 33758 79507551
Neurodevelopmental disorder 32.65 10.63 10 203069 46 79541263
Blood pressure diastolic abnormal 32.50 10.63 5 203074 19197 79522112
Upper respiratory tract infection 32.35 10.63 121 202958 91047 79450262
Hyperchloraemia 32.10 10.63 25 203054 1096 79540213
Systemic inflammatory response syndrome 31.88 10.63 82 202997 11383 79529926
Colitis 31.78 10.63 89 202990 73218 79468091
Drug dependence 31.75 10.63 195 202884 40574 79500735
Rebound effect 31.72 10.63 62 203017 7164 79534145
Adjustment disorder with mixed anxiety and depressed mood 31.51 10.63 12 203067 117 79541192
Epileptic psychosis 31.49 10.63 10 203069 53 79541256
Mitochondrial cytopathy 31.48 10.63 17 203062 393 79540916
Faecaloma 31.43 10.63 82 202997 11482 79529827
Aura 31.39 10.63 23 203056 919 79540390
Distractibility 31.39 10.63 21 203058 724 79540585
Sudden death 31.36 10.63 127 202952 22384 79518925
Febrile convulsion 31.30 10.63 23 203056 923 79540386
Glycosuria 31.27 10.63 33 203046 2155 79539154
Lymphocyte count increased 31.18 10.63 55 203024 5877 79535432
Screaming 31.14 10.63 44 203035 3889 79537420
Epidermolysis bullosa 31.14 10.63 14 203065 214 79541095
Respiratory acidosis 31.04 10.63 80 202999 11120 79530189
Rash pruritic 31.02 10.63 87 202992 71542 79469767
Rabbit syndrome 30.54 10.63 16 203063 347 79540962
Renal fusion anomaly 30.51 10.63 7 203072 6 79541303
Thought blocking 30.45 10.63 14 203065 226 79541083
Hypertelorism 30.39 10.63 12 203067 130 79541179
Disorganised speech 30.38 10.63 32 203047 2085 79539224
Neutrophil Pelger-Huet anomaly present 30.38 10.63 16 203063 351 79540958
Neoplasm malignant 30.34 10.63 22 203057 31788 79509521
Kidney infection 30.26 10.63 9 203070 21842 79519467
COVID-19 pneumonia 30.16 10.63 18 203061 28831 79512478
Septic shock 30.12 10.63 186 202893 122615 79418694
Rebound psychosis 30.09 10.63 16 203063 358 79540951
Bone marrow oedema syndrome 30 10.63 9 203070 38 79541271
Myelosuppression 29.98 10.63 35 203044 40261 79501048
Sinus disorder 29.77 10.63 10 203069 22454 79518855
Clostridium difficile infection 29.74 10.63 39 203040 42646 79498663
Hepatic cirrhosis 29.73 10.63 27 203052 34879 79506430
Peripheral venous disease 29.71 10.63 3 203076 15906 79525403
Limb discomfort 29.70 10.63 24 203055 32826 79508483
Device issue 29.65 10.63 16 203063 27092 79514217
Muscular weakness 29.59 10.63 264 202815 160465 79380844
Syncope 29.54 10.63 303 202776 179146 79362163
Taste disorder 29.51 10.63 3 203076 15820 79525489
Balance disorder 29.50 10.63 383 202696 98474 79442835
Monocyte count increased 29.39 10.63 76 203003 10585 79530724
Stress 29.34 10.63 104 202975 79508 79461801
Faeces discoloured 29.31 10.63 19 203060 29108 79512201
Clonus 29.19 10.63 58 203021 6782 79534527
Reflexes abnormal 29.13 10.63 22 203057 921 79540388
Suspiciousness 29.11 10.63 19 203060 628 79540681
Choking 29.07 10.63 82 202997 12019 79529290
Ovarian granulosa-theca cell tumour 29.03 10.63 8 203071 23 79541286
Fanconi syndrome acquired 28.90 10.63 35 203044 2659 79538650
Blister 28.77 10.63 182 202897 119294 79422015
Blood triglycerides increased 28.75 10.63 118 202961 20922 79520387
Right ventricular failure 28.56 10.63 12 203067 23485 79517824
Anion gap increased 28.54 10.63 41 203038 3679 79537630
Eosinophil count decreased 28.39 10.63 39 203040 3357 79537952
Cardiac disorder 28.38 10.63 80 202999 65677 79475632
Post-injection delirium sedation syndrome 28.34 10.63 18 203061 567 79540742
Productive cough 28.33 10.63 122 202957 88209 79453100
CSF oligoclonal band present 28.32 10.63 16 203063 405 79540904
Surgery 28.32 10.63 25 203054 32741 79508568
Anaemia macrocytic 28.27 10.63 51 203028 5546 79535763
Pectus excavatum 28.25 10.63 7 203072 11 79541298
Blood pressure systolic abnormal 28.06 10.63 5 203074 17242 79524067
Motor dysfunction 28.04 10.63 92 202987 14641 79526668
Blood osmolarity increased 28.04 10.63 19 203060 669 79540640
Pneumatosis 28.04 10.63 21 203058 868 79540441
Neurological decompensation 28.00 10.63 49 203030 5204 79536105
Sciatica 27.94 10.63 26 203053 33196 79508113
Subileus 27.90 10.63 51 203028 5603 79535706
Ketosis-prone diabetes mellitus 27.84 10.63 8 203071 28 79541281
Procedural pain 27.72 10.63 12 203067 23072 79518237
Psychotic behaviour 27.70 10.63 23 203056 1106 79540203
Simple partial seizures 27.65 10.63 19 203060 685 79540624
Oropharyngeal oedema 27.46 10.63 16 203063 430 79540879
Incontinence 27.46 10.63 89 202990 14075 79527234
Developmental coordination disorder 27.43 10.63 6 203073 3 79541306
Product administered to patient of inappropriate age 27.29 10.63 50 203029 5503 79535806
Product administration error 27.17 10.63 156 202923 31690 79509619
Presyncope 27.10 10.63 39 203040 41015 79500294
Anaphylactic shock 27.07 10.63 31 203048 35965 79505344
Dysphonia 26.98 10.63 66 203013 56806 79484503
Asthma-chronic obstructive pulmonary disease overlap syndrome 26.94 10.63 37 203042 3184 79538125
Injection site haemorrhage 26.94 10.63 19 203060 27851 79513458
Grip strength decreased 26.86 10.63 11 203068 21858 79519451
Blood gases abnormal 26.82 10.63 23 203056 1157 79540152
Haemorrhage 26.75 10.63 130 202949 90988 79450321
Haemorrhoids 26.68 10.63 21 203058 29107 79512202
Pleocytosis 26.67 10.63 25 203054 1414 79539895
Failure to suspend medication 26.56 10.63 16 203063 458 79540851
Drug-disease interaction 26.37 10.63 22 203057 1065 79540244
Niemann-Pick disease 26.26 10.63 8 203071 36 79541273
Myoglobinuria 26.14 10.63 22 203057 1078 79540231
Second primary malignancy 26.05 10.63 3 203076 14347 79526962
Suspected suicide attempt 25.91 10.63 14 203065 324 79540985
Memory impairment 25.83 10.63 414 202665 111320 79429989
Skin disorder 25.78 10.63 29 203050 33914 79507395
Amenorrhoea 25.65 10.63 59 203020 7633 79533676
Medication error 25.35 10.63 277 202802 68365 79472944
Sinus tachycardia 25.34 10.63 171 202908 36737 79504572
Renal impairment 25.32 10.63 268 202811 157515 79383794
Multiple congenital abnormalities 25.27 10.63 10 203069 109 79541200
Constipation 25.23 10.63 539 202540 282511 79258798
Hepatotoxicity 25.23 10.63 220 202859 51132 79490177
Dyscalculia 25.19 10.63 10 203069 110 79541199
Aspiration 25.18 10.63 110 202969 20048 79521261
Oral candidiasis 25.13 10.63 23 203056 29605 79511704
Necrotising colitis 25.13 10.63 21 203058 1019 79540290
Dysphagia 25.11 10.63 444 202635 121692 79419617
Immunodeficiency 25.08 10.63 12 203067 21756 79519553
Ear pain 25.05 10.63 28 203051 32841 79508468
Wound infection 25.04 10.63 15 203064 23976 79517333
Dry mouth 25.02 10.63 127 202952 87892 79453417
Oral herpes 24.89 10.63 20 203059 27434 79513875
Hypotelorism of orbit 24.88 10.63 5 203074 0 79541309
Shock 24.85 10.63 193 202886 43355 79497954
Neuralgia 24.83 10.63 29 203050 33355 79507954
Lactate pyruvate ratio increased 24.77 10.63 9 203070 76 79541233
Troponin increased 24.76 10.63 106 202973 19149 79522160
Hypoventilation 24.74 10.63 56 203023 7168 79534141
Injection site warmth 24.74 10.63 4 203075 14803 79526506
Heart rate irregular 24.73 10.63 28 203051 32651 79508658
Therapeutic product effect variable 24.71 10.63 28 203051 1981 79539328
Candida infection 24.55 10.63 37 203042 38177 79503132
Nodule 24.53 10.63 14 203065 22980 79518329
Eye pain 24.51 10.63 36 203043 37542 79503767
Cerebral ventricle dilatation 24.44 10.63 21 203058 1059 79540250
Anisometropia 24.38 10.63 6 203073 9 79541300
White blood cell count decreased 24.35 10.63 640 202439 187648 79353661
Adrenal insufficiency 24.30 10.63 22 203057 28465 79512844
Bradypnoea 24.26 10.63 50 203029 6002 79535307
Pancreatic carcinoma 24.24 10.63 3 203076 13574 79527735
Device related infection 24.23 10.63 31 203048 34263 79507046
Blood loss anaemia 24.14 10.63 5 203074 15493 79525816
Hereditary ataxia 24.04 10.63 7 203072 26 79541283
Torticollis 23.97 10.63 30 203049 2357 79538952
Brain malformation 23.95 10.63 8 203071 51 79541258
Hyperphagia 23.93 10.63 31 203048 2521 79538788
Vomiting 23.91 10.63 1420 201659 664408 78876901
Joint effusion 23.91 10.63 8 203071 18006 79523303
Decreased gait velocity 23.90 10.63 11 203068 178 79541131
Metabolic disorder 23.88 10.63 64 203015 9106 79532203
Injection site rash 23.78 10.63 8 203071 17946 79523363
Cardiogenic shock 23.76 10.63 44 203035 41870 79499439
Blood urea decreased 23.75 10.63 34 203045 3041 79538268
Hernia 23.67 10.63 7 203072 17052 79524257
Ultrasound ovary abnormal 23.61 10.63 9 203070 88 79541221
Transplant rejection 23.51 10.63 10 203069 19427 79521882
Inappropriate schedule of product administration 23.51 10.63 222 202857 133406 79407903
Dry eye 23.49 10.63 36 203043 36895 79504414
Accidental overdose 23.47 10.63 177 202902 39404 79501905
Ammonia abnormal 23.41 10.63 11 203068 187 79541122
Throat tightness 23.28 10.63 22 203057 27885 79513424
Swollen tongue 22.99 10.63 46 203033 42524 79498785
Hypothyroidism 22.97 10.63 219 202860 52173 79489136
Colitis ulcerative 22.94 10.63 33 203046 34709 79506600
Brain death 22.87 10.63 47 203032 5630 79535679
Ageusia 22.76 10.63 7 203072 16625 79524684
Frontotemporal dementia 22.75 10.63 16 203063 599 79540710
Musculoskeletal discomfort 22.75 10.63 11 203068 19824 79521485
Gamma-glutamyltransferase increased 22.71 10.63 226 202853 54454 79486855
Gene mutation 22.69 10.63 31 203048 2655 79538654
Blood urine present 22.67 10.63 13 203066 21284 79520025
Antisocial behaviour 22.67 10.63 17 203062 704 79540605
Blood osmolarity decreased 22.54 10.63 22 203057 1309 79540000
Microstomia 22.54 10.63 5 203074 3 79541306
Angina unstable 22.53 10.63 7 203072 16520 79524789
Injury 22.50 10.63 111 202968 77385 79463924
Coagulopathy 22.48 10.63 163 202916 35843 79505466
Gynaecomastia 22.47 10.63 56 203023 7625 79533684
Squamous cell carcinoma 22.44 10.63 6 203073 15616 79525693
Hyperexplexia 22.38 10.63 7 203072 35 79541274
Ventricular arrhythmia 22.32 10.63 61 203018 8779 79532530
Hyperreflexia 22.32 10.63 59 203020 8326 79532983
Hypersomnia 22.32 10.63 117 202962 22969 79518340
Tooth infection 22.28 10.63 10 203069 18822 79522487
Carpal tunnel syndrome 22.14 10.63 11 203068 19517 79521792
Sputum discoloured 22.13 10.63 14 203065 21729 79519580
Nephrocalcinosis 22.09 10.63 23 203056 1479 79539830
Blood sodium increased 22.08 10.63 42 203037 4756 79536553
Galactorrhoea 22.07 10.63 36 203043 3610 79537699
Angioedema 22.02 10.63 109 202970 75926 79465383
Reduced facial expression 21.99 10.63 31 203048 2734 79538575
Postural tremor 21.84 10.63 17 203062 745 79540564
Diabetic coma 21.79 10.63 21 203058 1230 79540079
Epileptic aura 21.77 10.63 8 203071 70 79541239
Developmental regression 21.75 10.63 7 203072 39 79541270
Crying 21.74 10.63 116 202963 22927 79518382
Pneumothorax 21.72 10.63 24 203055 28299 79513010
Lymphangioleiomyomatosis 21.66 10.63 10 203069 163 79541146
Sarcopenia 21.60 10.63 14 203065 457 79540852
IVth nerve disorder 21.58 10.63 6 203073 18 79541291
Hostility 21.57 10.63 28 203051 2282 79539027
Hip fracture 21.54 10.63 28 203051 30733 79510576
Illogical thinking 21.28 10.63 8 203071 75 79541234
Skin cancer 21.18 10.63 6 203073 15034 79526275
Alcohol abuse 21.14 10.63 44 203035 5319 79535990
Hiatus hernia 21.11 10.63 17 203062 23295 79518014
Clostridium difficile colitis 20.98 10.63 31 203048 32252 79509057
Intervertebral disc degeneration 20.97 10.63 7 203072 15778 79525531
Metastases to lung 20.94 10.63 10 203069 18153 79523156
Diffuse large B-cell lymphoma 20.94 10.63 3 203076 12146 79529163
Gliosis 20.89 10.63 14 203065 484 79540825
Circadian rhythm sleep disorder 20.85 10.63 16 203063 686 79540623
Thermal burn 20.73 10.63 52 203027 7108 79534201
Febrile bone marrow aplasia 20.70 10.63 4 203075 13016 79528293
Gastric ulcer 20.66 10.63 34 203045 33871 79507438
Talipes 20.54 10.63 9 203070 129 79541180
Megacolon 20.47 10.63 34 203045 3461 79537848
Therapy interrupted 20.47 10.63 30 203049 31311 79509998
Movement disorder 20.36 10.63 129 202950 27130 79514179
Gallbladder disorder 20.31 10.63 12 203067 19328 79521981
Personal relationship issue 20.28 10.63 10 203069 190 79541119
Full blood count decreased 20.27 10.63 23 203056 26796 79514513
Feeling cold 20.27 10.63 26 203053 28703 79512606
Gastroenteritis viral 20.22 10.63 20 203059 24811 79516498
Neutrophilia 20.21 10.63 55 203024 7896 79533413
Enteritis 20.20 10.63 6 203073 14577 79526732
Colon cancer 20.08 10.63 6 203073 14517 79526792
Gout 20.08 10.63 20 203059 24729 79516580
Feeling of despair 20.07 10.63 30 203049 2791 79538518
Nephrolithiasis 20.05 10.63 69 203010 53222 79488087
Coma hepatic 19.99 10.63 19 203060 1094 79540215
Basilar artery occlusion 19.96 10.63 10 203069 197 79541112
Congenital nose malformation 19.90 10.63 4 203075 0 79541309
Gaucher's disease 19.90 10.63 4 203075 0 79541309
Alpers disease 19.90 10.63 4 203075 0 79541309
Intelligence test abnormal 19.90 10.63 4 203075 0 79541309
Hypocarnitinaemia 19.90 10.63 4 203075 0 79541309
Disturbance in social behaviour 19.85 10.63 41 203038 4929 79536380
Deja vu 19.81 10.63 7 203072 54 79541255
Clonic convulsion 19.78 10.63 20 203059 1242 79540067
Hypophosphataemic osteomalacia 19.78 10.63 12 203067 348 79540961
Irregular sleep phase 19.76 10.63 8 203071 93 79541216
Hypersomnia-bulimia syndrome 19.75 10.63 5 203074 9 79541300
Polydipsia psychogenic 19.64 10.63 10 203069 204 79541105
Chronic kidney disease 19.64 10.63 94 202985 66060 79475249
Mucosal ulceration 19.55 10.63 24 203055 1849 79539460
Lymphoma 19.55 10.63 10 203069 17450 79523859
Urine amphetamine positive 19.53 10.63 8 203071 96 79541213
Dissociation 19.50 10.63 36 203043 3985 79537324
Device difficult to use 19.49 10.63 5 203074 13380 79527929
Trismus 19.42 10.63 43 203036 5424 79535885
High arched palate 19.41 10.63 5 203074 10 79541299
Low set ears 19.38 10.63 8 203071 98 79541211
Dyspraxia 19.38 10.63 11 203068 281 79541028
Post transplant lymphoproliferative disorder 19.37 10.63 3 203076 11461 79529848
Transient ischaemic attack 19.31 10.63 69 203010 52626 79488683
Tooth disorder 19.29 10.63 23 203056 26210 79515099
Therapeutic response changed 19.27 10.63 20 203059 1281 79540028
Intervertebral disc protrusion 19.26 10.63 19 203060 23602 79517707
Neglect of personal appearance 19.21 10.63 9 203070 152 79541157
Patient isolation 19.17 10.63 7 203072 60 79541249
Mixed delusion 19.09 10.63 5 203074 11 79541298
Hyporesponsive to stimuli 19.02 10.63 25 203054 2063 79539246
Muscle twitching 19.00 10.63 118 202961 24646 79516663
Eye movement disorder 18.97 10.63 54 203025 7957 79533352
Renal cancer 18.93 10.63 4 203075 12222 79529087
Drug monitoring procedure incorrectly performed 18.88 10.63 13 203066 470 79540839
Ankylosing spondylitis 18.88 10.63 4 203075 12201 79529108
Polyarthritis 18.88 10.63 4 203075 12198 79529111
Device dislocation 18.85 10.63 23 203056 25947 79515362
Cataplexy 18.81 10.63 17 203062 917 79540392
Pneumonia fungal 18.79 10.63 3 203076 11207 79530102
Aminoaciduria 18.78 10.63 12 203067 382 79540927
Patent ductus arteriosus 18.75 10.63 8 203071 107 79541202
School refusal 18.71 10.63 6 203073 33 79541276
Tendon rupture 18.71 10.63 4 203075 12122 79529187
Therapeutic product effective for unapproved indication 18.69 10.63 8 203071 108 79541201
Hyporeflexia 18.65 10.63 33 203046 3535 79537774
Procalcitonin increased 18.63 10.63 30 203049 2976 79538333
Substance-induced psychotic disorder 18.57 10.63 32 203047 3357 79537952
Fistula 18.53 10.63 5 203074 12935 79528374
Influenza like illness 18.43 10.63 107 202972 71600 79469709
Exostosis 18.36 10.63 10 203069 16848 79524461
Anticholinergic syndrome 18.36 10.63 33 203046 3578 79537731
Blood potassium decreased 18.34 10.63 59 203020 46453 79494856
Enterocolitis 18.31 10.63 7 203072 14505 79526804
Product use issue 18.27 10.63 401 202678 209421 79331888
Eye infection 18.25 10.63 4 203075 11916 79529393
Posterior reversible encephalopathy syndrome 18.19 10.63 122 202957 26159 79515150
Hepatitis C virus test positive 18.16 10.63 12 203067 405 79540904
Venoocclusive liver disease 17.92 10.63 4 203075 11767 79529542
Rickets 17.88 10.63 7 203072 74 79541235
Asphyxia 17.84 10.63 68 203011 11652 79529657
Blood pressure diastolic decreased 17.77 10.63 31 203048 30185 79511124
Lipids 17.74 10.63 5 203074 16 79541293
Hypotonia neonatal 17.71 10.63 7 203072 76 79541233
Shock haemorrhagic 17.71 10.63 15 203064 20045 79521264
Sedation complication 17.70 10.63 83 202996 15586 79525723
Delusional disorder, mixed type 17.67 10.63 4 203075 3 79541306
Camptodactyly congenital 17.67 10.63 4 203075 3 79541306
Blood pyruvic acid increased 17.67 10.63 4 203075 3 79541306
Aptyalism 17.57 10.63 15 203064 750 79540559
Dermatitis 17.56 10.63 17 203062 21304 79520005
Water intoxication 17.41 10.63 15 203064 759 79540550
Hepatic enzyme increased 17.37 10.63 344 202735 182266 79359043
Therapeutic product ineffective for unapproved indication 17.31 10.63 9 203070 192 79541117
Lacrimation increased 17.29 10.63 19 203060 22458 79518851
Glaucoma 17.17 10.63 15 203064 19746 79521563
Hepatic steatosis 17.17 10.63 159 202920 37579 79503730
Withdrawal catatonia 17.15 10.63 9 203070 196 79541113
Astigmatism 17.11 10.63 18 203061 1171 79540138
Multiple allergies 17.09 10.63 3 203076 10457 79530852
Anticonvulsant drug level therapeutic 17.08 10.63 5 203074 19 79541290
Adverse event 17.05 10.63 87 202992 60127 79481182
Burning sensation 17.01 10.63 84 202995 58548 79482761
Wrong schedule 17.00 10.63 11 203068 358 79540951
Mucosal erosion 16.99 10.63 25 203054 2293 79539016
Malignant catatonia 16.98 10.63 12 203067 453 79540856
Extensor plantar response 16.89 10.63 22 203057 1799 79539510
Emotional disorder of childhood 16.88 10.63 5 203074 20 79541289
Hypertrophic cardiomyopathy 16.81 10.63 25 203054 2315 79538994
Compensatory sweating 16.79 10.63 6 203073 48 79541261
Diplopia 16.76 10.63 144 202935 33322 79507987
Erythema multiforme 16.75 10.63 89 202990 17562 79523747
Frequent bowel movements 16.75 10.63 31 203048 29508 79511801
Opisthotonus 16.71 10.63 14 203065 682 79540627
Parkinsonian gait 16.67 10.63 16 203063 932 79540377
Accidental death 16.67 10.63 35 203044 4256 79537053
Influenza B virus test positive 16.65 10.63 11 203068 371 79540938
Electrocardiogram QRS complex prolonged 16.61 10.63 63 203016 10770 79530539
Gender dysphoria 16.58 10.63 6 203073 50 79541259
Cardiac steatosis 16.58 10.63 6 203073 50 79541259
Echopraxia 16.58 10.63 6 203073 50 79541259
Conversion disorder 16.51 10.63 22 203057 1839 79539470
Osteomyelitis 16.50 10.63 37 203042 32828 79508481
Injection site urticaria 16.50 10.63 6 203073 12820 79528489
Heat stroke 16.46 10.63 21 203058 1682 79539627
Oesophageal carcinoma 16.41 10.63 4 203075 11080 79530229
Acquired macroglossia 16.36 10.63 9 203070 216 79541093
Clinodactyly 16.32 10.63 5 203074 23 79541286
Disease recurrence 16.28 10.63 178 202901 43931 79497378
Unmasking of previously unidentified disease 16.27 10.63 23 203056 2034 79539275
Blunted affect 16.26 10.63 12 203067 485 79540824
Megakaryocytes abnormal 16.19 10.63 7 203072 97 79541212
Abdominal distension 16.19 10.63 211 202868 119439 79421870
Pyromania 16.15 10.63 5 203074 24 79541285
Myelodysplastic syndrome 16.14 10.63 33 203046 30268 79511041
Duodenal ulcer 16.03 10.63 11 203068 16358 79524951
Psychomotor disadaptation syndrome 16.00 10.63 7 203072 100 79541209
Jaundice cholestatic 15.99 10.63 64 203015 11220 79530089
Pulmonary valve incompetence 15.98 10.63 22 203057 1898 79539411
Substance abuse 15.97 10.63 61 203018 10465 79530844
Eczema 15.94 10.63 52 203027 40766 79500543
Middle insomnia 15.92 10.63 82 202997 15987 79525322
Rotator cuff syndrome 15.89 10.63 8 203071 14087 79527222
Infertility male 15.87 10.63 7 203072 102 79541207
Intention tremor 15.86 10.63 14 203065 732 79540577
Atrial flutter 15.86 10.63 19 203060 21606 79519703
Hyperhomocysteinaemia 15.84 10.63 12 203067 505 79540804
Inhibitory drug interaction 15.79 10.63 35 203044 4418 79536891
Prothrombin time shortened 15.78 10.63 29 203050 3199 79538110
Haematotoxicity 15.78 10.63 10 203069 15509 79525800
Tooth abscess 15.74 10.63 11 203068 16199 79525110
Neutrophil count decreased 15.71 10.63 331 202748 93628 79447681
Snoring 15.67 10.63 40 203039 5526 79535783
Embolism 15.66 10.63 8 203071 13974 79527335
Monocytosis 15.63 10.63 16 203063 1008 79540301
Back disorder 15.61 10.63 5 203074 11573 79529736
Condition aggravated 15.58 10.63 1480 201599 499644 79041665
Nose deformity 15.50 10.63 8 203071 168 79541141
Poor venous access 15.50 10.63 14 203065 18135 79523174
Teratogenicity 15.44 10.63 9 203070 242 79541067
Laboratory test abnormal 15.41 10.63 30 203049 28018 79513291
Skin fissures 15.38 10.63 7 203072 13066 79528243
Mastication disorder 15.37 10.63 26 203053 2687 79538622
Hyperpyrexia 15.35 10.63 42 203037 6050 79535259
Poor personal hygiene 15.29 10.63 12 203067 532 79540777
Major depression 15.27 10.63 54 203025 8926 79532383
Posturing 15.26 10.63 16 203063 1037 79540272
Pneumonia bacterial 15.25 10.63 16 203063 19315 79521994
Blood parathyroid hormone decreased 15.22 10.63 4 203075 10532 79530777
Electrocardiogram J wave abnormal 15.21 10.63 4 203075 9 79541300
Congenital renal disorder 15.21 10.63 4 203075 9 79541300
Sperm concentration decreased 15.19 10.63 6 203073 65 79541244
Idiosyncratic drug reaction 15.16 10.63 18 203061 1339 79539970
Temporal lobe epilepsy 15.11 10.63 11 203068 435 79540874
Rash morbilliform 15.09 10.63 42 203037 6108 79535201
Diabetic hyperosmolar coma 15.07 10.63 14 203065 783 79540526
Hypokalaemia 15.04 10.63 267 202812 143773 79397536
Cerebral arteriosclerosis 15.04 10.63 14 203065 785 79540524
Oral pain 15.00 10.63 37 203042 31761 79509548
Acute psychosis 14.98 10.63 33 203046 4147 79537162
Hypercalcaemia 14.98 10.63 49 203030 38381 79502928
Anticoagulation drug level decreased 14.97 10.63 8 203071 181 79541128
Feminisation acquired 14.95 10.63 5 203074 32 79541277
Musculoskeletal chest pain 14.94 10.63 25 203054 24739 79516570
Congenital eyelid malformation 14.93 10.63 3 203076 0 79541309
Diabetic encephalopathy 14.93 10.63 3 203076 0 79541309
Lisfranc fracture 14.93 10.63 3 203076 0 79541309
Nasopharyngeal reflux 14.93 10.63 3 203076 0 79541309
Dacryoadenitis acquired 14.93 10.63 3 203076 0 79541309
Drug level therapeutic 14.93 10.63 3 203076 0 79541309
Retrognathia 14.93 10.63 3 203076 0 79541309
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 14.93 10.63 3 203076 0 79541309
Congenital scoliosis 14.93 10.63 3 203076 0 79541309
Social (pragmatic) communication disorder 14.93 10.63 3 203076 0 79541309
Pathogen resistance 14.92 10.63 9 203070 14333 79526976
Glioblastoma multiforme 14.91 10.63 17 203062 1211 79540098
Graft versus host disease 14.85 10.63 10 203069 15016 79526293
Retinitis pigmentosa 14.85 10.63 7 203072 120 79541189
Compulsive shopping 14.79 10.63 14 203065 802 79540507
Cholangitis 14.78 10.63 7 203072 12769 79528540
Skin haemorrhage 14.76 10.63 6 203073 11975 79529334
Diverticulum 14.60 10.63 10 203069 14886 79526423
Infusion site pain 14.60 10.63 9 203070 14167 79527142
Haematuria 14.52 10.63 109 202970 68727 79472582
Tenosynovitis 14.52 10.63 11 203068 15543 79525766
Dermatitis contact 14.47 10.63 5 203074 11028 79530281
Gastric cancer 14.45 10.63 4 203075 10175 79531134
Locomotive syndrome 14.39 10.63 4 203075 12 79541297
Amino acid metabolism disorder 14.39 10.63 4 203075 12 79541297
Urine sodium increased 14.36 10.63 8 203071 197 79541112
Respiratory arrest 14.35 10.63 216 202863 57334 79483975
Lacrimal gland enlargement 14.33 10.63 5 203074 37 79541272
Squamous cell carcinoma of skin 14.33 10.63 9 203070 14024 79527285
Delusional perception 14.32 10.63 10 203069 370 79540939
Deep vein thrombosis 14.32 10.63 219 202860 120700 79420609
Lower gastrointestinal haemorrhage 14.30 10.63 12 203067 16113 79525196
Drug eruption 14.29 10.63 173 202906 43762 79497547
Small intestinal obstruction 14.27 10.63 30 203049 27242 79514067
Organising pneumonia 14.27 10.63 5 203074 10934 79530375
Neck pain 14.26 10.63 123 202956 75294 79466015
MELAS syndrome 14.25 10.63 8 203071 200 79541109
Gingival atrophy 14.22 10.63 6 203073 78 79541231
SARS-CoV-2 test positive 14.21 10.63 6 203073 11710 79529599
Granuloma skin 14.21 10.63 3 203076 9171 79532138
Amino acid level increased 14.17 10.63 13 203066 715 79540594
Blood creatinine increased 14.17 10.63 294 202785 154763 79386546
Upper-airway cough syndrome 14.17 10.63 6 203073 11687 79529622
Vitamin B6 decreased 14.15 10.63 4 203075 13 79541296
Hepatocellular injury 14.03 10.63 184 202895 47409 79493900
Insomnia 14.01 10.63 761 202318 244409 79296900
Visuospatial deficit 13.99 10.63 5 203074 40 79541269
Pulmonary eosinophilia 13.98 10.63 13 203066 728 79540581
Autoimmune disorder 13.97 10.63 13 203066 16599 79524710
Rotavirus infection 13.96 10.63 13 203066 729 79540580
Electrocardiogram T wave abnormal 13.96 10.63 30 203049 3708 79537601
Executive dysfunction 13.94 10.63 9 203070 292 79541017
Altered visual depth perception 13.93 10.63 10 203069 387 79540922
Abulia 13.90 10.63 15 203064 1005 79540304
Type 1 diabetes mellitus 13.89 10.63 44 203035 6875 79534434
Derealisation 13.88 10.63 19 203060 1630 79539679
Immunosuppressant drug level increased 13.88 10.63 3 203076 9024 79532285
Slow response to stimuli 13.84 10.63 20 203059 1805 79539504
Libido increased 13.84 10.63 21 203058 1980 79539329
Urine calcium/creatinine ratio increased 13.83 10.63 7 203072 141 79541168
Factor XIII deficiency 13.76 10.63 6 203073 85 79541224
Brain injury 13.74 10.63 62 203017 11455 79529854
Ehlers-Danlos syndrome 13.74 10.63 7 203072 143 79541166
Hypomagnesaemia 13.72 10.63 67 203012 46844 79494465
Generalised anxiety disorder 13.72 10.63 22 203057 2175 79539134
Angular cheilitis 13.67 10.63 13 203066 749 79540560
Lip haemorrhage 13.61 10.63 16 203063 1178 79540131
Seasonal allergy 13.61 10.63 13 203066 16393 79524916
Gastroenteritis 13.60 10.63 43 203036 34039 79507270
Alanine aminotransferase abnormal 13.53 10.63 3 203076 8864 79532445
Cardiac failure acute 13.49 10.63 17 203062 18912 79522397
Lower limb fracture 13.49 10.63 24 203055 23191 79518118
Wrong product administered 13.48 10.63 52 203027 8960 79532349
Opsoclonus myoclonus 13.44 10.63 8 203071 224 79541085
Lip swelling 13.43 10.63 56 203023 40855 79500454
Tooth malformation 13.40 10.63 7 203072 151 79541158
Sinus bradycardia 13.37 10.63 110 202969 25137 79516172
Terminal insomnia 13.36 10.63 16 203063 1201 79540108
Thyroxine free decreased 13.34 10.63 15 203064 1052 79540257
Bronchospasm 13.30 10.63 27 203052 24832 79516477
Aphthous ulcer 13.30 10.63 14 203065 16875 79524434
Emotional disorder 13.28 10.63 72 203007 14315 79526994
Ejaculation disorder 13.27 10.63 11 203068 528 79540781
Skin irritation 13.25 10.63 6 203073 11234 79530075
Osteoporosis 13.24 10.63 82 202997 54030 79487279
Gastrointestinal sounds abnormal 13.22 10.63 37 203042 5398 79535911
Body temperature decreased 13.22 10.63 40 203039 32105 79509204
Personality disorder 13.19 10.63 40 203039 6106 79535203
Lip erosion 13.17 10.63 18 203061 1542 79539767
Hydronephrosis 13.16 10.63 15 203064 17439 79523870
Coma blister 13.16 10.63 8 203071 233 79541076
Toothache 13.15 10.63 19 203060 19951 79521358
Near drowning 13.11 10.63 5 203074 49 79541260
Blood cholesterol increased 13.10 10.63 143 202936 83577 79457732
Spinal fracture 13.09 10.63 16 203063 18038 79523271
Illusion 13.08 10.63 19 203060 1722 79539587
Precocious puberty 13.06 10.63 9 203070 326 79540983
Malignant melanoma 13.04 10.63 11 203068 14730 79526579
Skin reaction 13.02 10.63 13 203066 16055 79525254
Optic atrophy 12.96 10.63 20 203059 1913 79539396
Breast cancer metastatic 12.94 10.63 3 203076 8599 79532710
Polyserositis 12.89 10.63 12 203067 673 79540636
Drug screen false positive 12.87 10.63 15 203064 1094 79540215
Tubo-ovarian abscess 12.87 10.63 9 203070 334 79540975
Hyperthyroidism 12.87 10.63 23 203056 22186 79519123
Coloboma 12.86 10.63 3 203076 3 79541306
Autoimmune hepatitis 12.82 10.63 7 203072 11776 79529533
Eosinophil count increased 12.81 10.63 81 202998 17024 79524285
Bipolar II disorder 12.79 10.63 10 203069 441 79540868
Strabismus 12.77 10.63 23 203056 2498 79538811
Pancreatitis haemorrhagic 12.73 10.63 13 203066 817 79540492
Arthropod bite 12.66 10.63 3 203076 8468 79532841
Pupillary reflex impaired 12.62 10.63 27 203052 3326 79537983
Blood bicarbonate increased 12.60 10.63 16 203063 1276 79540033
Tinnitus 12.58 10.63 64 203015 44269 79497040
Acne 12.55 10.63 32 203047 27158 79514151
Compulsive sexual behaviour 12.54 10.63 8 203071 254 79541055
Blood insulin increased 12.47 10.63 9 203070 351 79540958
Sleep-related eating disorder 12.46 10.63 12 203067 702 79540607
Synovial cyst 12.46 10.63 5 203074 10060 79531249
Intermittent explosive disorder 12.40 10.63 3 203076 4 79541305
Retinal function test abnormal 12.40 10.63 3 203076 4 79541305
Intraocular pressure increased 12.37 10.63 4 203075 9201 79532108
Sinus rhythm 12.37 10.63 13 203066 845 79540464
Serositis 12.37 10.63 13 203066 845 79540464
Urosepsis 12.37 10.63 31 203048 26464 79514845
Attention-seeking behaviour 12.36 10.63 6 203073 110 79541199
Proctalgia 12.33 10.63 5 203074 9996 79531313
Spinal compression fracture 12.33 10.63 15 203064 16943 79524366
Arthritis bacterial 12.29 10.63 4 203075 9162 79532147
Blood citric acid increased 12.28 10.63 5 203074 59 79541250
Granuloma 12.27 10.63 3 203076 8294 79533015
Pneumonia viral 12.27 10.63 4 203075 9154 79532155
Rales 12.24 10.63 20 203059 19981 79521328
Swelling face 12.22 10.63 119 202960 71093 79470216
Parkinson's disease 12.22 10.63 18 203061 1653 79539656
Breast cancer female 12.19 10.63 7 203072 11454 79529855
Ejection fraction decreased 12.19 10.63 46 203033 34531 79506778
Peripheral arterial occlusive disease 12.19 10.63 3 203076 8255 79533054
Pulmonary thrombosis 12.16 10.63 8 203071 12163 79529146
Mass 12.13 10.63 16 203063 17456 79523853
Macroglossia 12.11 10.63 15 203064 1166 79540143
Blood calcium decreased 12.10 10.63 41 203038 31778 79509531
Hepatomegaly 12.10 10.63 86 202993 18788 79522521
Post procedural infection 12.04 10.63 7 203072 11377 79529932
Orthostatic tremor 12.04 10.63 4 203075 25 79541284
Osmolar gap increased 12.03 10.63 6 203073 117 79541192
Escherichia infection 12.01 10.63 17 203062 18000 79523309
Prominent epicanthal folds 12.00 10.63 3 203076 5 79541304
Malabsorption 11.99 10.63 34 203045 4998 79536311
Feeling abnormal 11.99 10.63 311 202768 158888 79382421
Hepatocellular carcinoma 11.98 10.63 4 203075 9017 79532292
Waxy flexibility 11.98 10.63 8 203071 275 79541034
Mean cell haemoglobin concentration decreased 11.97 10.63 32 203047 4547 79536762
Endocarditis 11.97 10.63 6 203073 10591 79530718
Nephropathy toxic 11.96 10.63 21 203058 20398 79520911
Epileptic encephalopathy 11.95 10.63 10 203069 486 79540823
Haematuria traumatic 11.95 10.63 7 203072 190 79541119
Renal tubular necrosis 11.92 10.63 29 203050 25010 79516299
Lipids abnormal 11.92 10.63 11 203068 610 79540699
Vascular encephalopathy 11.89 10.63 11 203068 612 79540697
Alcohol use 11.86 10.63 33 203046 4798 79536511
Spinal pain 11.85 10.63 13 203066 15379 79525930
Large intestine polyp 11.85 10.63 9 203070 12699 79528610
SJS-TEN overlap 11.84 10.63 12 203067 747 79540562
Systemic infection 11.82 10.63 5 203074 9747 79531562
Cerebral palsy 11.82 10.63 7 203072 194 79541115
Hepatitis fulminant 11.78 10.63 43 203036 7219 79534090
Skin exfoliation 11.74 10.63 87 202992 55013 79486296
Musculoskeletal disorder 11.73 10.63 23 203056 21425 79519884
Coronary artery occlusion 11.72 10.63 13 203066 15302 79526007
Oxygen saturation decreased 11.70 10.63 245 202834 128802 79412507
Cytotoxic oedema 11.69 10.63 9 203070 388 79540921
Heparin-induced thrombocytopenia 11.68 10.63 5 203074 9677 79531632
Herbal interaction 11.68 10.63 10 203069 502 79540807
Head injury 11.66 10.63 146 202933 37223 79504086
Mitochondrial enzyme deficiency 11.66 10.63 4 203075 28 79541281
Ornithine transcarbamoylase deficiency 11.65 10.63 3 203076 6 79541303
Drug half-life reduced 11.65 10.63 3 203076 6 79541303
Rasmussen encephalitis 11.65 10.63 3 203076 6 79541303
Congenital renal cyst 11.65 10.63 3 203076 6 79541303
Haemodynamic instability 11.61 10.63 80 202999 17302 79524007
Sarcoidosis 11.59 10.63 47 203032 8288 79533021
Internal haemorrhage 11.59 10.63 4 203075 8829 79532480
Hyperdynamic left ventricle 11.57 10.63 9 203070 394 79540915
Dysuria 11.56 10.63 79 203000 50872 79490437
Diarrhoea haemorrhagic 11.55 10.63 10 203069 13224 79528085
CSF white blood cell count positive 11.54 10.63 4 203075 29 79541280
Acidosis 11.51 10.63 88 202991 19674 79521635
Coma acidotic 11.50 10.63 6 203073 129 79541180
Sickle cell anaemia with crisis 11.46 10.63 3 203076 7919 79533390
Cyst 11.44 10.63 11 203068 13829 79527480
Restless legs syndrome 11.44 10.63 89 202990 20003 79521306
Haemoglobin decreased 11.42 10.63 456 202623 221663 79319646
Nipple disorder 11.42 10.63 7 203072 207 79541102
Abdominal pain lower 11.39 10.63 42 203037 31740 79509569
Mixed anxiety and depressive disorder 11.37 10.63 9 203070 404 79540905
Non-cardiac chest pain 11.36 10.63 5 203074 9519 79531790
Femoral neck fracture 11.36 10.63 53 203026 9931 79531378
Eclampsia 11.36 10.63 7 203072 209 79541100
Blood bicarbonate decreased 11.34 10.63 34 203045 5157 79536152
Hypoproteinaemia 11.31 10.63 29 203050 4017 79537292
Spinal disorder 11.30 10.63 6 203073 10254 79531055
Eye pruritus 11.30 10.63 22 203057 20548 79520761
Gastrointestinal hypomotility 11.30 10.63 19 203060 1954 79539355
Tooth extraction 11.30 10.63 7 203072 10988 79530321
Cyclothymic disorder 11.30 10.63 7 203072 211 79541098
Groin pain 11.28 10.63 10 203069 13070 79528239
Limb injury 11.26 10.63 38 203041 29490 79511819
Renal injury 11.25 10.63 16 203063 16911 79524398
Embolic stroke 11.25 10.63 3 203076 7823 79533486
Hypertransaminasaemia 11.23 10.63 60 203019 11864 79529445
False positive investigation result 11.21 10.63 14 203065 1098 79540211
Poriomania 11.18 10.63 7 203072 215 79541094
Monocyte count decreased 11.17 10.63 25 203054 3176 79538133
Electrocardiogram abnormal 11.17 10.63 77 203002 16660 79524649
Phlebitis superficial 11.14 10.63 11 203068 664 79540645
Eructation 11.13 10.63 7 203072 10902 79530407
Congenital foot malformation 11.09 10.63 4 203075 33 79541276
Rheumatoid nodule 11.09 10.63 17 203062 17421 79523888
Postoperative wound infection 11.07 10.63 10 203069 12951 79528358
Blood bicarbonate abnormal 11.06 10.63 6 203073 140 79541169
Electrocardiogram QT shortened 11.04 10.63 7 203072 220 79541089
Cytopenia 11.03 10.63 22 203057 20361 79520948
Pharyngeal swelling 11.02 10.63 3 203076 7716 79533593
Acute pulmonary oedema 10.98 10.63 12 203067 14218 79527091
Genital erosion 10.96 10.63 9 203070 426 79540883
Neutropenic sepsis 10.90 10.63 34 203045 27030 79514279
Dependence 10.90 10.63 21 203058 2401 79538908
Acute graft versus host disease in skin 10.89 10.63 3 203076 7655 79533654
Dependence on oxygen therapy 10.87 10.63 10 203069 552 79540757
Glassy eyes 10.83 10.63 6 203073 146 79541163
Scrotal haematoma 10.80 10.63 5 203074 82 79541227
Urine cannabinoids increased 10.79 10.63 3 203076 9 79541300
Appendicitis 10.78 10.63 23 203056 20771 79520538
Skin discharge 10.75 10.63 5 203074 83 79541226
Decreased appetite 10.75 10.63 739 202340 341679 79199630
Self esteem decreased 10.72 10.63 13 203066 989 79540320
Acute generalised exanthematous pustulosis 10.71 10.63 78 203001 17176 79524133
Hypoacusis 10.70 10.63 40 203039 30110 79511199
Illiteracy 10.69 10.63 4 203075 37 79541272
Subacute sclerosing panencephalitis 10.69 10.63 4 203075 37 79541272
Antidepressant drug level increased 10.66 10.63 9 203070 443 79540866
Pelvic pain 10.64 10.63 11 203068 13370 79527939
Multiple sclerosis relapse 10.63 10.63 72 203007 46461 79494848

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal anticonvulsant syndrome 149.99 22.92 41 839 0 88912
Congenital nose malformation 58.31 22.92 16 864 0 88912
Low set ears 42.14 22.92 15 865 20 88892
Dysmorphism 37.27 22.92 32 848 402 88510
Cardiomegaly 29.12 22.92 8 872 0 88912
Developmental delay 28.09 22.92 14 866 61 88851

Pharmacologic Action:

SourceCodeDescription
ATC N03AG01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
CHEBI has role CHEBI:35477 antimanic drugs
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
CHEBI has role CHEBI:35471 psychotropic drugs
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:61115 histone deacetylase inhibitors
CHEBI has role CHEBI:63726 neuroprotective agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Bipolar affective disorder, current episode manic indication 191618007
Epilepsy characterized by intractable complex partial seizures indication 442481002
Migraine Prevention indication
Bipolar disorder off-label use 13746004 DOID:3312
Mixed bipolar I disorder off-label use 16506000 DOID:3312
Myoclonic seizure off-label use 37356005
Bipolar disorder in remission off-label use 85248005
Seizure disorder off-label use 128613002
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Tonic-clonic epilepsy off-label use 352818000 DOID:7725
Simple partial seizure off-label use 117891000119100
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Hyperammonemia contraindication 9360008
Arginase deficiency contraindication 23501004 DOID:9278
Depressive disorder contraindication 35489007
Congenital hyperammonemia, type I contraindication 62522004
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Hypoalbuminemia contraindication 119247004
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Poisoning by sodium valproate contraindication 241754000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Hypothermia contraindication 386689009
Citrullinemia contraindication 398680004 DOID:9273
Porphyria contraindication 418470004
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Succinate-semialdehyde dehydrogenase, mitochondrial Enzyme INHIBITOR CHEMBL CHEMBL
Histone deacetylase 2 Enzyme IC50 4.21 CHEMBL
Histone deacetylase 1 Enzyme INHIBITOR IC50 6.40 IUPHAR
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
UDP-glucuronosyltransferase 1-5 Enzyme WOMBAT-PK
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.05 CHEMBL
Aldose reductase Enzyme IC50 4.25 CHEMBL
Aldose reductase Enzyme IC50 4.24 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Aldose reductase-related protein 1 Enzyme IC50 4.25 CHEMBL

External reference:

IDSource
4022507 VUID
N0000147028 NUI
D00304 KEGG_DRUG
76584-70-8 SECONDARY_CAS_RN
1069-66-5 SECONDARY_CAS_RN
4018723 VANDF
4018724 VANDF
4018728 VANDF
4022507 VANDF
C0042291 UMLSCUI
CHEBI:39867 CHEBI
2PP PDB_CHEM_ID
CHEMBL109 ChEMBL_ID
DB00313 DRUGBANK_ID
CHEMBL2105613 ChEMBL_ID
CHEMBL433 ChEMBL_ID
D014635 MESH_DESCRIPTOR_UI
3121 PUBCHEM_CID
3300 INN_ID
7009 IUPHAR_LIGAND_ID
33433-82-8 SECONDARY_CAS_RN
614OI1Z5WI UNII
11118 RXNORM
147344 MMSL
17039 MMSL
203066 MMSL
255547 MMSL
3118 MMSL
4624 MMSL
5661 MMSL
5662 MMSL
942 MMSL
d00083 MMSL
d03833 MMSL
001622 NDDF
001623 NDDF
001624 NDDF
006036 NDDF
007107 NDDF
13965000 SNOMEDCT_US
387080000 SNOMEDCT_US
387481005 SNOMEDCT_US
5641004 SNOMEDCT_US
CHEMBL2315212 ChEMBL_ID
5132 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 32 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 32 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 32 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7326 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7401 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7401 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7401 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections