azaribine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
ribofuranyl-derivatives of the "pyrazofurin" type	27	2169-64-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

azaribine
triazure
azaribin
triacetyl-6-azauridine
triacetyl azauridine
6-azauridine triacetate

pyrimidine analogue; anti-metabolite used in psoriasis & mycosis fungoides

Molecular weight: 371.30
Formula: C14H17N3O9
CLOGP: 0.19
LIPINSKI: 1
HAC: 12
HDO: 1
TPSA: 149.90
ALOGS: -2.12
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003879	Dermatologic Agents
CHEBI has role	CHEBI:35221	antimetabolite
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:49103	drug metabolites
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:50748	antipsoriatic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.42	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Orotidine 5'-phosphate decarboxylase	Enzyme		PYRF_METTH		Ki	4.96		CHEMBL
Orotidine 5'-phosphate decarboxylase	Enzyme		PYRF_YEAST		Ki	7.19		CHEMBL

External reference:

ID	Source
D03029	KEGG_DRUG
CHEBI:88272	CHEBI
CHEBI:35668	CHEBI
CHEMBL515914	ChEMBL_ID
C100231	MESH_SUPPLEMENTAL_RECORD_UI
2502	INN_ID
K1U80DO9EB	UNII
C0052757	UMLSCUI
C0004483	UMLSCUI
CHEMBL564201	ChEMBL_ID
16574	PUBCHEM_CID
54-25-1	SECONDARY_CAS_RN
5901	PUBCHEM_CID
7BVB29RCPR	UNII
002651	NDDF

Pharmaceutical products:

None