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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
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Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
valdecoxib ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
selective cyclo-oxygenase inhibitors
2799
181695-72-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
valdecoxib
valecoxib
a COX-2 inhibitor
Molecular weight: 314.36
Formula: C16H14N2O3S
CLOGP: 1.83
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 86.19
ALOGS: -3.96
ROTB: 3
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
10
mg
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
83 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
7.40 hours
Lombardo F, Berellini G, Obach RS
MRTD (Maximum Recommended Therapeutic Daily Dose)
2.12 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)
1.40 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.75 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.02 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 7 of 7 entries
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Approvals:
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Date
Agency
Company
Orphan
Nov. 16, 2001
FDA
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Drug hypersensitivity
190.23
82.49
59
150
310628
63178185
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Drug hypersensitivity
209.51
85.89
50
51
298866
79445421
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
M01AH03
MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
CHEBI has role
CHEBI:35475
non-steroidal anti-inflammatory agent
CHEBI has role
CHEBI:35493
anti-pyretic
CHEBI has role
CHEBI:35842
anti-rheumatic drugs
CHEBI has role
CHEBI:50629
COX-2 inhibitor
MeSH PA
D000700
Analgesics
MeSH PA
D018712
Analgesics, Non-Narcotic
MeSH PA
D000893
Anti-Inflammatory Agents
MeSH PA
D000894
Anti-Inflammatory Agents, Non-Steroidal
MeSH PA
D018501
Antirheumatic Agents
Showing 1 to 10 of 15 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Acute postoperative pain
indication
107401000119105
Rheumatoid arthritis
off-label use
69896004
DOID:7148
Dysmenorrhea
off-label use
266599000
Osteoarthritis
off-label use
396275006
Showing 1 to 4 of 4 entries
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.85
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prostaglandin G/H synthase 2
Enzyme
P35354
PGH2_HUMAN
INHIBITOR
IC50
8.30
WOMBAT-PK
CHEMBL
Prostaglandin G/H synthase 1
Enzyme
P23219
PGH1_HUMAN
IC50
4.57
CHEMBL
Sodium-dependent noradrenaline transporter
Transporter
P23975
SC6A2_HUMAN
Ki
5.54
DRUG MATRIX
5-hydroxytryptamine receptor 2B
GPCR
P41595
5HT2B_HUMAN
Ki
5.74
PDSP
Carbonic anhydrase 2
Enzyme
P00918
CAH2_HUMAN
IC50
7.37
WOMBAT-PK
Carbonic anhydrase 1
Enzyme
P00915
CAH1_HUMAN
Ki
4.27
CHEMBL
Carbonic anhydrase 4
Enzyme
P22748
CAH4_HUMAN
Ki
5.87
CHEMBL
Carbonic anhydrase 9
Enzyme
Q16790
CAH9_HUMAN
IC50
7.57
WOMBAT-PK
Carbonic anhydrase 12
Enzyme
O43570
CAH12_HUMAN
Ki
7.89
CHEMBL
Carbonic anhydrase 5A, mitochondrial
Enzyme
P35218
CAH5A_HUMAN
Ki
6.04
CHEMBL
Showing 1 to 10 of 37 entries
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External reference:
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ID
Source
COX
PDB_CHEM_ID
009503
NDDF
119607
PUBCHEM_CID
16210
MMSL
278567
RXNORM
2894
IUPHAR_LIGAND_ID
2919279Q3W
UNII
385583007
SNOMEDCT_US
385584001
SNOMEDCT_US
4021284
VUID
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Pharmaceutical products:
None
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valdecoxib